-
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells.
Basic & clinical pharmacology & toxicology 20120901
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The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells.
Cancer letters 20120828
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Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects.
Respiratory medicine 20120801
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Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Bioorganic & medicinal chemistry letters 20120801
-
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Journal of medicinal chemistry 20120322
-
Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism.
PloS one 20120101
-
Prostaglandins in cancer cell adhesion, migration, and invasion.
International journal of cell biology 20120101
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Anti-inflammatory drugs and prediction of new structures by comparative analysis.
Anti-inflammatory & anti-allergy agents in medicinal chemistry 20120101
-
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
Cancer prevention research (Philadelphia, Pa.) 20111201
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Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone.
British journal of pharmacology 20110901
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Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.
Annals of the rheumatic diseases 20110801
-
Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration.
Cancer prevention research (Philadelphia, Pa.) 20110801
-
Licofelone-nitric oxide donors as anticancer agents.
Archiv der Pharmazie 20110801
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Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.
Annals of the rheumatic diseases 20110601
-
Antibody-mediated 'universal' osteoclast targeting platform using calcitonin as a model drug.
Pharmaceutical research 20110501
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Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
Journal of medicinal chemistry 20110428
-
Licofelone attenuates quinolinic acid induced Huntington like symptoms: possible behavioral, biochemical and cellular alterations.
Progress in neuro-psychopharmacology & biological psychiatry 20110330
-
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
European journal of medicinal chemistry 20110301
-
[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part I].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110101
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Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model.
Arthritis research & therapy 20110101
-
The implications of relationships between human diseases and metabolic subpathways.
PloS one 20110101
-
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.
BMC musculoskeletal disorders 20110101
-
Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis.
PloS one 20110101
-
Quantitative cartilage imaging in knee osteoarthritis.
Arthritis 20110101
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Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis.
Annals of the rheumatic diseases 20101201
-
Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.
Annals of the rheumatic diseases 20101201
-
Licofelone attenuates MPTP-induced neuronal toxicity: behavioral, biochemical and cellular evidence.
Inflammopharmacology 20101001
-
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice.
Atherosclerosis 20100901
-
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
European journal of medicinal chemistry 20100201
-
Pharmacophore modeling and virtual screening for designing potential 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry letters 20100201
-
Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes.
Arthritis research & therapy 20100101
-
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.
Arthritis research & therapy 20100101
-
Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis.
Arthritis research & therapy 20100101
-
Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells.
BMC research notes 20100101
-
Investigational pharmacology for low back pain.
Journal of pain research 20100101
-
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.
Frontiers in pharmacology 20100101
-
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.
Annals of the rheumatic diseases 20090601
-
Systematic review of the management of canine osteoarthritis.
The Veterinary record 20090404
-
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Arthritis research & therapy 20090101
-
An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
BMC veterinary research 20090101
-
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
Arthritis research & therapy 20090101
-
The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer.
Biologics : targets & therapy 20081201
-
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
The Journal of pharmacology and experimental therapeutics 20080901
-
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
Drug metabolism and disposition: the biological fate of chemicals 20080501
-
The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands.
Annals of the rheumatic diseases 20080401
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20080301
-
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Carcinogenesis 20080201
-
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors.
Prostaglandins, leukotrienes, and essential fatty acids 20080201
-
A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models.
BMC musculoskeletal disorders 20080101
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20080101
-
Licofelone: the answer to unmet needs in osteoarthritis therapy?
Current rheumatology reports 20080101
-
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Diagnostic pathology 20080101
-
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
Arthritis research & therapy 20080101
-
Finding multiple target optimal intervention in disease-related molecular network.
Molecular systems biology 20080101
-
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.
Arthritis research & therapy 20080101
-
Combination Therapy of PPARgamma Ligands and Inhibitors of Arachidonic Acid in Lung Cancer.
PPAR research 20080101
-
Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor.
The Journal of pharmacology and experimental therapeutics 20071201
-
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
British journal of pharmacology 20071001
-
Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond.
Acta bio-medica : Atenei Parmensis 20070801
-
Efficacy of licofelone in dogs with clinical osteoarthritis.
The Veterinary record 20070428
-
Dynamic simulations on the arachidonic acid metabolic network.
PLoS computational biology 20070301
-
Activity and potential role of licofelone in the management of osteoarthritis.
Clinical interventions in aging 20070301
-
Arthritis clinical trial results revealed.
JAMA 20070103
-
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
The Journal of pharmacology and experimental therapeutics 20070101
-
Licofelone--a novel analgesic and anti-inflammatory agent.
Current topics in medicinal chemistry 20070101
-
Selection of reliable reference genes for qPCR studies on chondroprotective action.
BMC molecular biology 20070101
-
Extracellular localization of galectin-3 has a deleterious role in joint tissues.
Arthritis research & therapy 20070101
-
Anticancer effects of licofelone (ML-3000) in prostate cancer cells.
Anticancer research 20070101
-
DMOAD developments: present and future.
Bulletin of the NYU hospital for joint diseases 20070101
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Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.
Arthritis research & therapy 20070101
-
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity.
Journal of cardiovascular medicine (Hagerstown, Md.) 20061201
-
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
European journal of pharmacology 20060928
-
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
The Journal of rheumatology 20060601
-
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Fundamental & clinical pharmacology 20060201
-
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.
Arthritis research & therapy 20060101
-
Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.
Biochemical pharmacology 20050701
-
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Annals of the rheumatic diseases 20050601
-
Eicosanoids, osteoarthritis, and crystal deposition diseases.
Current opinion in rheumatology 20050501
-
Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation?
Joint, bone, spine : revue du rhumatisme 20050501
-
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
The Journal of rheumatology 20050401
-
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Indian journal of experimental biology 20050301
-
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs.
Journal of veterinary pharmacology and therapeutics 20050201
-
Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone.
Drugs & aging 20050101
-
Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain.
Pharmacological reports : PR 20050101
-
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Arthritis research & therapy 20050101
-
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Arthritis and rheumatism 20041201
-
Pain and osteoarthritis: new drugs and mechanisms.
Current opinion in rheumatology 20040901
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20040901
-
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial.
The American journal of gastroenterology 20040401
-
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
European journal of pharmacology 20040319
-
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Bone 20040301
-
Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy?
Fundamental & clinical pharmacology 20040201
-
Osteoarthritis therapy--are there still unmet needs?
Rheumatology (Oxford, England) 20040201
-
Safety of anti-inflammatory treatment--new ways of thinking.
Rheumatology (Oxford, England) 20040201
-
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Rheumatology (Oxford, England) 20040201
-
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Annals of the rheumatic diseases 20040101
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20040101
-
Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000.
BMC gastroenterology 20040101
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20031201
-
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
British journal of pharmacology 20030801
-
Licofelone (Merckle).
IDrugs : the investigational drugs journal 20030801
-
International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium.
Expert opinion on investigational drugs 20030701
-
The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy.
Prostaglandins & other lipid mediators 20030701
-
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030601
-
Anti arthritic drugs--SMi conference: dual inhibitors. 28-29 April 2003, London, UK.
IDrugs : the investigational drugs journal 20030601
-
COX-LOX inhibition: current evidence for an emerging new therapy.
International journal of clinical practice 20030501
-
Licofelone, a dual lipoxygenase-cyclooxygenase inhibitor, downregulates polymorphonuclear leukocyte and platelet function.
European journal of pharmacology 20021018
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20021001
-
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Arthritis and rheumatism 20020701
-
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
The Journal of rheumatology 20020701
-
Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020301
-
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020301
-
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Arthritis and rheumatism 20011001
-
[Double blockade should protect the stomach. New approach to rheumatism].
MMW Fortschritte der Medizin 20010920
-
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.
The Journal of rheumatology 20010901
