157115-85-0 | Noopept

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$6.00	$4.00
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$18.00	$13.00
25g	98%	in stock	$55.00	$38.00
100g	98%	in stock	$162.00	$114.00

Description

• Catalog Number: AA79149
• Chemical Name: Noopept
• CAS Number: 157115-85-0
• Molecular Formula: C17H22N2O4
• Molecular Weight: 318.3676
• MDL Number: MFCD00941121
• SMILES: CCOC(=O)CNC(=O)[C@@H]1CCCN1C(=O)Cc1ccccc1

Computed Properties

• Complexity: 432
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 1.5

Literature

• Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity.

  Journal of molecular biology 20111216

• [Peptidergic modulation of the hippocampus synaptic activity].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20111101

• Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors.

  Brain research bulletin 20110530

• [Strategy for the development of dipeptide drugs].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20110101

• [Analysis of the binding capacity of the benzodiazepine site of gabaa receptor in mice C57BL/6 and BALB/C pretreated with anxiolytics].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• [Noopept in the treatment of mild cognitive impairment in patients with stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• [On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

  Eksperimental'naia i klinicheskaia farmakologiia 20101201

• Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells.

  Neuroscience letters 20100531

• [Effect of the novel nootropic and neuroprotective dipeptide noopept on the streptozotocin-induced model of sporadic Alzheimer disease in rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20100101

• Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin.

  Neuroscience and behavioral physiology 20090301

• Noopept reduces the postischemic functional and metabolic disorders in the brain of rats with different sensitivity to hypoxia.

  Bulletin of experimental biology and medicine 20090301

• Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept.

  Neuroscience and behavioral physiology 20090101

• [Prevention of neuro- and cardiotoxic side effects of tuberculosis chemotherapy with noopept].

  Klinicheskaia meditsina 20090101

• [Efficacy of noopept in discirculatory encephalopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• [The original nootropic and neuroprotective drug noopept potentiates the anticonvulsant activity of valproate in mice].

  Eksperimental'naia i klinicheskaia farmakologiia 20090101

• Noopept stimulates the expression of NGF and BDNF in rat hippocampus.

  Bulletin of experimental biology and medicine 20080901

• Original nootropic drug noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade.

  Bulletin of experimental biology and medicine 20080701

• Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats).

  Bulletin of experimental biology and medicine 20080701

• [A comparative study of noopept and piracetam in the treatment of mild and moderate cognitive impairment in patients with organic brain diseases of vascular and traumatic origin].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [The using of noopept in treatment of neurasthenia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.

  Journal of psychopharmacology (Oxford, England) 20070801

• Immunopharmacological properties of noopept.

  Bulletin of experimental biology and medicine 20070701

• Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice.

  Bulletin of experimental biology and medicine 20070401

• [Effects of noopept and cortexin on the behavior of matured rats treated with corticoliberin or 70-kDa heat shock proteins in early ontogeny].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• [Behavior of mice from different strains: modifications produced by noopept].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20070101

• [Genotype-dependent mice behavior in cognitive tasks. Effect of noopept].

  Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20070101

• Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis.

  Bulletin of experimental biology and medicine 20060801

• [Neuroprotective activity of the proline-containing dipeptide noopept on the model of brain ischemia induced by the middle cerebral artery occlusion].

  Eksperimental'naia i klinicheskaia farmakologiia 20060101

• Early postnatal effects of noopept and piracetam on declarative and procedural memory of adult male and female rats.

  Bulletin of experimental biology and medicine 20050601

• [Comparative study of the long-term behavioral effects of noopept and piracetam in adult male rats and female rats in postnatal period].

  Eksperimental'naia i klinicheskaia farmakologiia 20050101

• [Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice].

  Eksperimental'naia i klinicheskaia farmakologiia 20050101

• Relationship between changes in rat behavior and integral biochemical indexes determined by laser correlation spectroscopy after photothrombosis of the prefrontal cortex.

  Bulletin of experimental biology and medicine 20040201

• [Interspecies differences of noopept pharmacokinetics].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats.

  Bulletin of experimental biology and medicine 20030801

• Cyclopropyl glycine and proline-containing preparation noopept evoke two types of membrane potential responses in synaptoneurosomes.

  Bulletin of experimental biology and medicine 20030601

• GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20030501

• [Regulation of the neuronal functional state by ultra low doses of different biologically active substances. Nonspecific effect ].

  Radiatsionnaia biologiia, radioecologiia 20030101

• [Evolution of the neuroprotection concept].

  Eksperimental'naia i klinicheskaia farmakologiia 20030101

• [Pharmacological regulation of emotional stress reactions].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101

• Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept.

  Bulletin of experimental biology and medicine 20021201

• Selective suppression of the slow-inactivating potassium currents by nootropics in molluscan neurons.

  The international journal of neuropsychopharmacology 20020901

• [Preclinical study of noopept toxicity].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• [Effect of the novel dipeptide nootropic agent noopept and its metabolite cyclo-L-prolylglycine on the transcallosal evoked potential in the rat brain].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• [Multicomponent antithrombotic effect of the neuroprotective prolyl dipeptide GVS-111 and its major metabolite cyclo-L-prolylglycine].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• [The original novel nootropic and neuroprotective agent noopept].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• [The role of non-NMDA glutamate receptors in the EEG effects of chronic administration of noopept GVS-111 in awake rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20020101

• Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.

  Bulletin of experimental biology and medicine 20011001

• [Behavioral and electrophysiological analysis of the choline-positive effect of nootropic dipeptide acylproline (GVS-111)].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• [Effect of nootropic agents on impulse activity of cerebral cortex neurons].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101