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Home  > Chemistry  > Heterocyclic Building Blocks  > Other Aromatic Heterocycles  > 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridine DiHCl

AA79345

157327-44-1 | 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridine DiHCl

Packsize Purity Availability Price Discounted Price    Quantity
1g 95% in stock $24.00 $17.00 -   +
5g 95% in stock $70.00 $49.00 -   +
10g 95% in stock $139.00 $98.00 -   +

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Description
Catalog Number: AA79345
Chemical Name: 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridine DiHCl
CAS Number: 157327-44-1
Molecular Formula: C6H11Cl2N3
Molecular Weight: 196.0776
MDL Number: MFCD13176187
SMILES: C1NCc2c(C1)[nH]nc2.Cl.Cl

 

Computed Properties
Complexity: 105  
Covalently-Bonded Unit Count: 3  
Heavy Atom Count: 11  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 4  

 

 

Upstream Synthesis Route 
  • The upstream synthesis route of 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridine dihydrochloride typically begins with the condensation of an appropriate β-keto ester with hydrazine to form a pyrazolone intermediate. Next, the pyrazolone is cyclized under acidic conditions to yield the pyrazolo[4,3-c]pyridine skeleton. Reduction of the double bond with a suitable reducing agent like hydrogen in the presence of a metal catalyst affords the tetrahydro derivative. The dihydrochloride salt is then obtained by treating the free base with hydrogen chloride gas in an organic solvent like diethyl ether or ethanol. Multiple purification steps including recrystallization and chromatography may be required to attain the desired level of purity.
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