160096-59-3 | Dimethoxycurcumin

Packsize	Purity	Availability	Price	Discounted Price
1mg	90%	in stock	$38.00	$27.00
5mg	90%	in stock	$112.00	$79.00
10mg	90%	in stock	$168.00	$118.00
50mg	90%	in stock	$713.00	$499.00
100mg	90%	in stock	$1,192.00	$835.00

Description

• Catalog Number: AA82297
• Chemical Name: Dimethoxycurcumin
• CAS Number: 160096-59-3
• Molecular Formula: C23H24O6
• Molecular Weight: 396.4331
• MDL Number: MFCD22123809
• SMILES: COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(c(c2)OC)OC)ccc1OC

Computed Properties

• Complexity: 534
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• XLogP3: 3.9

Literature

• Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells.

  Journal of agricultural and food chemistry 20120822

• Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis.

  Archives of toxicology 20120401

• Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes.

  Biochemical pharmacology 20110915

• Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin.

  Free radical research 20110801

• Interaction of a curcumin analogue dimethoxycurcumin with DNA.

  Chemical biology & drug design 20110401

• Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure-activity relationship.

  Free radical research 20110301

• Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3.

  Korean journal of urology 20101201

• Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.

  European journal of medicinal chemistry 20101001

• Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.

  European journal of medicinal chemistry 20100301

• A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

  Bioorganic & medicinal chemistry letters 20090901

• Synthesis and evaluation of electron-rich curcumin analogues.

  Bioorganic & medicinal chemistry 20090101

• Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages.

  Journal of clinical biochemistry and nutrition 20090101

• Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.

  Molecular nutrition & food research 20080901

• Synthesis and exploration of novel curcumin analogues as anti-malarial agents.

  Bioorganic & medicinal chemistry 20080315

• Molecular interactions between dimethoxycurcumin and Pamam dendrimer carriers.

  International journal of pharmaceutics 20070718

• Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070215