1628260-79-6 | GLPG1690

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$120.00	$84.00
10mg	95%	in stock	$214.00	$150.00
100mg	95%	in stock	$289.00	$202.00
250mg	95%	in stock	$463.00	$324.00
1g	95%	in stock	$1,432.00	$1,002.00

Description

• Catalog Number: AA84621
• Chemical Name: GLPG1690
• CAS Number: 1628260-79-6
• Molecular Formula: C30H33FN8O2S
• Molecular Weight: 588.6988
• MDL Number: MFCD31544330
• SMILES: CCc1nc2n(c1CNc1sc(c(n1)c1ccc(cc1)F)C#N)cc(cc2C)N1CCN(CC1)CC(=O)N1CC(C1)O

Computed Properties

• Complexity: 995
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 42
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 4.8

Literature

• Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.

  Journal of medicinal chemistry 20170511

• Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.

  The Journal of pharmacology and experimental therapeutics 20170101

• The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis.

  European journal of pharmacology 20151015

• Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.

  American journal of respiratory and critical care medicine 20131015

• Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.

  Biochimica et biophysica acta 20130101

• Problems of the pathogenesis, clinics, and therapy of panarteritis of the aorta and its branches.

  Cor et vasa 19750101