16567-18-3 | 8-Bromoquinoline

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$9.00	$7.00
10g	98%	in stock	$16.00	$12.00
20g	98%	in stock	$22.00	$16.00
25g	98%	in stock	$25.00	$18.00
100g	98%	in stock	$70.00	$49.00

Description

• Catalog Number: AA88318
• Chemical Name: 8-Bromoquinoline
• CAS Number: 16567-18-3
• Molecular Formula: C9H6BrN
• Molecular Weight: 208.05464
• MDL Number: MFCD00191859
• SMILES: Brc1cccc2c1nccc2

Computed Properties

• Complexity: 138
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• XLogP3: 2.5

Upstream Synthesis Route

8-Bromoquinoline, a versatile chemical compound, finds wide application in chemical synthesis due to its unique properties and reactivity. In organic synthesis, 8-Bromoquinoline serves as a valuable building block for the construction of complex molecular architectures. Its bromine substituent imparts significant nucleophilic and electrophilic character, enabling diverse functional group transformations and facilitating the formation of new carbon-carbon and carbon-heteroatom bonds. Additionally, 8-Bromoquinoline can undergo various substitution reactions, such as Suzuki-Miyaura cross-coupling, Heck coupling, and Buchwald-Hartwig amination, leading to the synthesis of biologically active compounds, pharmaceutical intermediates, and materials with tailored properties. Moreover, the presence of the quinoline ring in 8-Bromoquinoline provides opportunities for further derivatization and modification, allowing chemists to explore a wide range of synthetic pathways to access novel molecules. In summary, 8-Bromoquinoline plays a crucial role in the realm of chemical synthesis, offering an array of possibilities for creating intricate organic structures and advancing scientific research and innovation.

Literature

• Reactivity of the bifunctional ambiphilic molecule 8-(dimesitylboryl)quinoline: hydrolysis and coordination to Cu(I), Ag(I) and Pd(II).

  Dalton transactions (Cambridge, England : 2003) 20101207

• Direct synthesis of tricyclic 5H-pyrido[3,2,1-ij]quinolin-3-one by domino palladium catalyzed reaction.

  Organic & biomolecular chemistry 20061021