1668-10-6 | Glycinamide, HCl

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$14.00	$10.00
25g	97%	in stock	$18.00	$12.00
100g	97%	in stock	$39.00	$27.00
500g	97%	in stock	$60.00	$42.00

Description

• Catalog Number: AA89179
• Chemical Name: Glycinamide, HCl
• CAS Number: 1668-10-6
• Molecular Formula: C2H7ClN2O
• Molecular Weight: 110.5428
• MDL Number: MFCD00013008
• SMILES: NCC(=O)N.Cl
• NSC Number: 9225

Computed Properties

• Complexity: 42.9
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1

Upstream Synthesis Route

Glycinamide Hydrochloride is a versatile compound frequently utilized in chemical synthesis processes. Its primary application lies in its role as a key precursor in the formation of various pharmaceuticals, such as antiviral medications and antibiotics. In organic synthesis, Glycinamide Hydrochloride serves as a valuable building block for the creation of complex molecules due to its ability to undergo various chemical transformations. With its strategic placement within synthetic pathways, this compound enables the efficient production of target molecules with high purity and yield. Additionally, Glycinamide Hydrochloride exhibits good solubility in many common solvents, further enhancing its utility in a wide range of chemical reactions.

Literature

• HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

  Bioorganic & medicinal chemistry letters 20130801

• Acylglycinamides as inhibitors of glycine transporter type 1.

  Bioorganic & medicinal chemistry letters 20111015

• N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.

  Bioorganic & medicinal chemistry letters 20110915

• Glycine amide shielding on the aromatic surfaces of lysozyme: implication for suppression of protein aggregation.

  FEBS letters 20110204

• [Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101101

• Well-defined synthetic polymers with a protein-like gelation behavior in water.

  Chemical communications (Cambridge, England) 20100707

• Glycine amides as PPARalpha agonists.

  Bioorganic & medicinal chemistry letters 20100601

• gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

  Bioorganic & medicinal chemistry letters 20100415

• Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

  Nature chemical biology 20090101

• Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology.

  Retrovirology 20090101

• Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity.

  Antimicrobial agents and chemotherapy 20081001

• Rapid cleavage of unactivated, unstrained amide bonds at neutral pH.

  The Journal of organic chemistry 20080815

• Investigation of anion retention and cation exclusion effects for several C18 stationary phases.

  Analytical chemistry 20070715

• Computational study of urea and its homologue glycinamide: conformations, rotational barriers, and relative interactions with sodium chloride.

  Langmuir : the ACS journal of surfaces and colloids 20070508

• The rate enhancement produced by the ribosome: an improved model.

  Biochemistry 20070403

• Preparation of guanine and diaminopurine from biuret. Part III.

  Chemistry & biodiversity 20070401

• Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.

  The journal of pain : official journal of the American Pain Society 20061001

• Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

  Bioorganic & medicinal chemistry letters 20060715

• Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.

  Bioconjugate chemistry 20060101

• [New biological active derivatives of indomethacin and acetylsalicylic acid. Synthesis, physico-chemical characterisation and structure validation].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101

• Synthesis of (-)-quinocarcin by directed condensation of alpha-amino aldehydes.

  Journal of the American Chemical Society 20051207

• Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.

  Journal of medicinal chemistry 20051201

• Kinetic investigation of the effect of the amino acid side chains in the selective acidolysis of N-acyl-N,alpha,alpha-trialkyl glycine amides.

  Journal of peptide science : an official publication of the European Peptide Society 20051001

• Kinetic and mechanistic investigation of the selective acidolysis of the C-terminal amide bond of N-acyl-N,alpha,alpha-trialkyl glycine amides.

  Journal of peptide science : an official publication of the European Peptide Society 20050701

• A potential prebiotic route to adenine from hypoxanthine.

  Chemistry & biodiversity 20050701

• Application of intramolecular 1,3-dipolar cyclic addition of azide and olefin; construction of (pyrrolidine-2-ylidene)glycinate and glycinamides.

  Chemical & pharmaceutical bulletin 20050501

• Double proton transfer and one-electron oxidation behavior in double H-bonded glycinamide-glycine complex in the gas phase.

  Journal of computational chemistry 20050430

• Highly enantioselective phase-transfer-catalyzed alkylation of protected alpha-amino acid amides toward practical asymmetric synthesis of vicinal diamines, alpha-amino ketones, and alpha-amino alcohols.

  Journal of the American Chemical Society 20050413

• Theoretical study of the effect of water in the process of proton transfer of glycinamide.

  The journal of physical chemistry. B 20050331

• Chiral ion-exchange capillary electrochromatography of arylglycine amides with dextran sulfate as a pseudostationary phase.

  Electrophoresis 20050201

• Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide.

  The Journal of biological chemistry 20050114

• Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide.

  Antimicrobial agents and chemotherapy 20050101

• Highly stereoselective Michael addition reactions of CamTHP*-desymmetrized glycinamide for the synthesis of functionally dense amino acid derivatives.

  Organic letters 20041125

• Double proton transfer behavior and one-electron oxidation effect in double H-bonded glycinamide-formic acid complex.

  The Journal of chemical physics 20041122

• Construction, characterization, and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel amidases.

  Environmental microbiology 20040901

• BMS-201620: a selective beta 3 agonist.

  Bioorganic & medicinal chemistry letters 20040705

• Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose?

  Human immunology 20040501

• One-step synthesis of hypoxanthine from glycinamide and diformylurea.

  Chemistry & biodiversity 20040101

• Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure.

  Biochemistry 20021231

• New 2H-tetrahydro-1, 3, 5-thiadiazine-2-thiones incorporating glycine and glycinamide as potential antifungal agents.

  Archiv der Pharmazie 20021101

• Synthetic Cu(II) and Ni(II) peptidases.

  Metal ions in biological systems 20010101