167869-21-8 | Pd 98059

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$25.00	$17.00
5mg	95%	in stock	$70.00	$49.00
10mg	95%	in stock	$79.00	$55.00
50mg	95%	in stock	$189.00	$133.00
100mg	95%	in stock	$320.00	$224.00
200mg	95%	in stock	$543.00	$380.00
250mg	95%	in stock	$555.00	$388.00
1g	95%	in stock	$1,496.00	$1,047.00

Description

• Catalog Number: AA90063
• Chemical Name: Pd 98059
• CAS Number: 167869-21-8
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.2793
• MDL Number: MFCD00671789
• SMILES: COc1cccc(c1N)c1cc(=O)c2c(o1)cccc2
• NSC Number: 679828

Computed Properties

• Complexity: 407
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.9

Literature

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• Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat thyroid cells.

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• Enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells.

  Journal of applied toxicology : JAT 20130701

• Periostin mediates the increased pro-angiogenic activity of gastric cancer cells under hypoxic conditions.

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• Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.

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• Zeranol upregulates corticotropin releasing hormone expression in the placental cell line JEG-3.

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  Toxicology 20130607

• Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells.

  Toxicology and applied pharmacology 20130601

• Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.

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• Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.

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• Kisspeptin stimulates progesterone secretion via the Erk1/2 mitogen-activated protein kinase signaling pathway in rat luteal cells.

  Fertility and sterility 20130401

• Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction.

  Toxicology in vitro : an international journal published in association with BIBRA 20130401

• β-Ionone attenuates LPS-induced pro-inflammatory mediators such as NO, PGE2 and TNF-α in BV2 microglial cells via suppression of the NF-κB and MAPK pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 20130301

• Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression.

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• Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis.

  Neurobiology of disease 20130101

• Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20130101

• A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

  PloS one 20130101

• MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia.

  PloS one 20130101

• GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism.

  PloS one 20130101

• Environmental alkylphenols modulate cytokine expression in plasmacytoid dendritic cells.

  PloS one 20130101

• Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells.

  The Journal of toxicological sciences 20130101

• Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes.

  PloS one 20130101

• Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level.

  Histochemistry and cell biology 20121201

• Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201

• Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells.

  Biochimica et biophysica acta 20121201

• Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.

  International journal of molecular medicine 20121201

• Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.

  The Journal of biological chemistry 20121102

• Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation.

  The Journal of biological chemistry 20121102

• Quercetin up-regulates LDL receptor expression in HepG2 cells.

  Phytotherapy research : PTR 20121101

• Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c.

  Cellular signalling 20121101

• Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells.

  Journal of cellular biochemistry 20121101

• Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells.

  Journal of cellular biochemistry 20121101

• Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.

  Toxicological sciences : an official journal of the Society of Toxicology 20121101

• Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121101

• Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway.

  Brain research 20121030

• Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.

  Toxicology 20121028

• The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway.

  Life sciences 20121015

• Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.

  Oral diseases 20121001

• Nickel nanoparticles enhance platelet-derived growth factor-induced chemokine expression by mesothelial cells via prolonged mitogen-activated protein kinase activation.

  American journal of respiratory cell and molecular biology 20121001

• Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymyxin B.

  Cytokine 20121001

• Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells.

  International journal of molecular medicine 20121001

• Pro-apoptotic role of the MEK/ERK pathway in ursodeoxycholic acid-induced apoptosis in SNU601 gastric cancer cells.

  Oncology reports 20121001

• Expression of LH receptor in nonpregnant mouse endometrium: LH induction of 3β-HSD and de novo synthesis of progesterone.

  The Journal of endocrinology 20121001

• Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.

  European journal of medicinal chemistry 20121001

• Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways.

  European journal of pharmacology 20120905

• ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism.

  Life sciences 20120904

• Central role of IL-6 and MMP-1 for cross talk between human intestinal mast cells and human intestinal fibroblasts.

  Immunobiology 20120901

• Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.

  Journal of molecular neuroscience : MN 20120901

• Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals.

  Toxicology and applied pharmacology 20120901

• GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes.

  The Journal of biological chemistry 20120803

• Prevention of ERK activation involves melatonin-induced G(1) and G(2) /M phase arrest in the human osteoblastic cell line hFOB 1.19.

  Journal of pineal research 20120801

• L-Leucine induces growth arrest and persistent ERK activation in glioma cells.

  Amino acids 20120801

• Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways.

  Experimental and molecular pathology 20120801

• PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

  Molecular and cellular biochemistry 20120801

• Inhibitory effect of Styrax Japonica Siebold et al. Zuccarini glycoprotein (38 kDa) on interleukin-1β and induction proteins in chromium(VI)-treated BNL CL.2 cells.

  Molecular and cellular biochemistry 20120801

• Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.

  Environmental health perspectives 20120801

• Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-κB.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells.

  Cytokine 20120801

• N-acetylglucosaminyltransferase V negatively regulates integrin α5β1-mediated monocyte adhesion and transmigration through vascular endothelium.

  International journal of oncology 20120801

• Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.

  International journal of rheumatic diseases 20120801

• Arachidonic acid stimulates TNFα production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism.

  American journal of physiology. Gastrointestinal and liver physiology 20120715

• Hypotonic stress upregulates β- and γ-ENaC expression through suppression of ERK by inducing MKP-1.

  American journal of physiology. Renal physiology 20120715

• Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.

  The Journal of biological chemistry 20120706

• Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.

  Pharmacological research 20120701

• MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis.

  The New phytologist 20120701

• Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress.

  American journal of physiology. Cell physiology 20120701

• Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling.

  Journal of cellular biochemistry 20120701

• Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120701

• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation.

  Oncogene 20120614

• ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.

  Inflammation 20120601

• Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.

  Endocrine-related cancer 20120601

• Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells.

  Oncology reports 20120601

• Lead induces dysregulation of iron regulatory protein 1 via the extracellular signal-regulated kinase pathway in human vascular endothelial cells.

  Brain research 20120521

• Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.

  American journal of physiology. Gastrointestinal and liver physiology 20120515

• PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.

  Journal of cellular physiology 20120501

• Effects of mitogen-activated protein kinase signaling pathway inhibition on the development of cerulein-induced acute pancreatitis in mice.

  Pancreas 20120501

• Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.

  Cellular signalling 20120501

• Chronic bradykinin treatment alters 1α,25-dihydroxyvitamin D3-induced calcium current modulation in pre-osteoblasts.

  Cell calcium 20120501

• Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

  Pharmacology, biochemistry, and behavior 20120501

• TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.

  Free radical research 20120501

• 1-Bromopropane up-regulates cyclooxygenase-2 expression via NF-κB and C/EBP activation in murine macrophages.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

• Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced lung cancer cell apoptosis.

  Molecular medicine reports 20120501

• S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.

  Experimental cell research 20120501

• Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.

  Nature immunology 20120501

• Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone.

  Journal of immunology (Baltimore, Md. : 1950) 20120501

• Lipopolysaccharide-induced stem cell factor messenger RNA expression and production in odontoblast-like cells.

  Journal of endodontics 20120501

• Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation.

  Die Pharmazie 20120501

• ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3.

  The Journal of biological chemistry 20120427

• Activation of HGF/c-Met signaling by ultrafine carbon particles and its contribution to alveolar type II cell proliferation.

  American journal of physiology. Lung cellular and molecular physiology 20120415

• Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism.

  Chemico-biological interactions 20120415

• Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum.

  Biochemical and biophysical research communications 20120413

• Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons.

  Molecular and cellular endocrinology 20120404

• Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.

  Journal of applied toxicology : JAT 20120401

• Interleukin-6 up-regulates the expression of interleukin-15 is associated with MAPKs and PI3-K signaling pathways in the human keratinocyte cell line, HaCaT.

  Molecular biology reports 20120401

• Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.

  Phytotherapy research : PTR 20120401

• L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos.

  Reproductive toxicology (Elmsford, N.Y.) 20120401

• The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.

  European heart journal 20120401

• 13-cis-Retinoic acid specific down-regulation of angiotensin type 1 receptor in rat liver epithelial and aortic smooth muscle cells.

  Journal of molecular endocrinology 20120401

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120401

• TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori.

  Insect biochemistry and molecular biology 20120401

• Mechanisms of the inhibition of nuclear factor-κB by morphine in neuronal cells.

  Molecular pharmacology 20120401

• K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2.

  Toxicology in vitro : an international journal published in association with BIBRA 20120401

• Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway.

  The Journal of endocrinology 20120401

• Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.

  European journal of pharmacology 20120315

• ERK and p38 MAPK signaling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells.

  Toxicology letters 20120307

• Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

• EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.

  American journal of physiology. Gastrointestinal and liver physiology 20120301

• Combination effects of cigarette smoke extract and ambient ultrafine particles on endothelial cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20120301

• GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB.

  Cytokine 20120301

• Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.

  Toxicology and applied pharmacology 20120301

• Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth.

  The Journal of biological chemistry 20120217

• Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism.

  Toxicology and applied pharmacology 20120215

• MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells.

  Toxicology 20120206

• Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro.

  Toxicology 20120206

• Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells.

  Toxicology letters 20120205

• The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling.

  Chemico-biological interactions 20120205

• Cadmium-induced apoptosis and necrosis in human osteoblasts: role of caspases and mitogen-activated protein kinases pathways.

  Journal of endocrinological investigation 20120201

• Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.

  Inflammation 20120201

• Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120201

• Lipopolysaccharide upregulates the expression of corticotropin-releasing hormone via MAP kinase pathway in rat peritoneal macrophages.

  Molecular and cellular biochemistry 20120201

• Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway.

  Archives of toxicology 20120201

• Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201

• Epidermal growth factor-activated extracellular signal-regulated kinase suppresses growth hormone expression and stimulates proliferation in MtT/ E cells.

  Journal of neuroendocrinology 20120201

• Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.

  Toxicological sciences : an official journal of the Society of Toxicology 20120201

• Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium.

  Biology of reproduction 20120201

• Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.

  Toxicology in vitro : an international journal published in association with BIBRA 20120201

• An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.

  Toxicological sciences : an official journal of the Society of Toxicology 20120201

• NADPH oxidase in plasma membrane is involved in stomatal closure induced by dehydroascorbate.

  Plant physiology and biochemistry : PPB 20120201

• Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.

  Toxicology and applied pharmacology 20120201

• ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling.

  Journal of molecular medicine (Berlin, Germany) 20120201

• [Study on mechanism of ginsenoside Rg1-induced human neural stem cells differentiation by genechip].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• p38 mitogen-activated protein kinase is a key regulator of 5-phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine-induced apoptosis in human HL-60 cells.

  Biochemical and biophysical research communications 20120106

• G-CSF downregulates natural killer cell-mediated cytotoxicity in donors for hematopoietic SCT.

  Bone marrow transplantation 20120101

• Novel evidence that testosterone promotes cell proliferation and differentiation via G protein-coupled receptors in the rat L6 skeletal muscle myoblast cell line.

  Journal of cellular physiology 20120101

• Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides.

  Arthritis and rheumatism 20120101

• Differential modulation of brainstem phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55,212-2 centrally mediated pressor response in conscious rats.

  The Journal of pharmacology and experimental therapeutics 20120101

• c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

  Anti-cancer drugs 20120101

• Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms.

  International journal of molecular medicine 20120101

• Hypoxia promotes rabbit pulmonary artery smooth muscle cells proliferation through a 15-LOX-2 product 15(S)-hydroxyeicosatetraenoic acid.

  Prostaglandins, leukotrienes, and essential fatty acids 20120101

• The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors.

  Toxicological sciences : an official journal of the Society of Toxicology 20120101

• Function of MAPK and downstream transcription factors in monomer-induced apoptosis.

  Biomaterials 20120101

• Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism.

  American journal of physiology. Gastrointestinal and liver physiology 20120101

• Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells.

  Molecular cancer therapeutics 20120101

• Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells.

  Peptides 20120101

• The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study.

  Journal of vascular research 20120101

• miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.

  PloS one 20120101

• Lewis y regulate cell cycle related factors in ovarian carcinoma cell RMG-I in vitro via ERK and Akt signaling pathways.

  International journal of molecular sciences 20120101

• Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK.

  International journal of molecular sciences 20120101

• Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.

  PloS one 20120101

• EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling.

  PloS one 20120101

• Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.

  PloS one 20120101

• EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?

  PloS one 20120101

• Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.

  BMC neurology 20120101

• AngiotensinII preconditioning promotes angiogenesis in vitro via ERKs phosphorylation.

  Journal of biomedicine & biotechnology 20120101

• The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells.

  Molecular vision 20120101

• Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation.

  PloS one 20120101

• Mifepristone increases the cytotoxicity of uterine natural killer cells by acting as a glucocorticoid antagonist via ERK activation.

  PloS one 20120101

• Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.

  Molecular pain 20120101

• Calcium-sensing receptor activation increases cell-cell adhesion and β-cell function.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression.

  Acta haematologica 20120101

• Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation.

  Journal of experimental & clinical cancer research : CR 20120101

• Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.

  PloS one 20120101

• Resveratrol prevents ammonia toxicity in astroglial cells.

  PloS one 20120101

• Deprenyl prevents MPP(+)-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk.

  Toxicology 20111218

• Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia.

  The Journal of biological chemistry 20111216

• Cellular adaptive response to glutathione depletion modulates endothelial dysfunction triggered by TNF-α.

  Toxicology letters 20111215

• Regulation of heat shock protein 27 phosphorylation during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line.

  Toxicology letters 20111215

• Permissive effect of EGFR-activated pathways on RVI and their anti-apoptotic effect in hypertonicity-exposed mIMCD3 cells.

  Bioscience reports 20111201

• Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.

  Molecular and cellular biochemistry 20111201

• PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin αvβ6.

  Cancer letters 20111201

• Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α.

  Environmental health perspectives 20111201

• Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

  Neurobiology of aging 20111201

• Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20111201

• Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

  American journal of physiology. Heart and circulatory physiology 20111201

• Functional analysis of guinea pig β1-adrenoceptor.

  Journal of receptor and signal transduction research 20111201

• Extracellular signal-regulated kinase (ERK) inhibition decreases arginase activity and improves corpora cavernosal relaxation in streptozotocin (STZ)-induced diabetic mice.

  The journal of sexual medicine 20111201

• Tetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20111201

• Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts.

  Peptides 20111201

• Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide.

  Journal of endodontics 20111201

• Progranulin stimulated by LPA promotes the migration of aggressive breast cancer cells.

  Cell communication & adhesion 20111201

• [The pharmacological mechanism of gastrodin on calcitonin gene-related peptide of cultured rat trigeminal ganglion].

  Yao xue xue bao = Acta pharmaceutica Sinica 20111201

• Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells.

  American journal of respiratory cell and molecular biology 20111101

• Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.

  Cytokine 20111101

• High calcium, ATP, and poly(I:C) augment the immune response to β-glucan in normal human epidermal keratinocytes.

  The Journal of investigative dermatology 20111101

• ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

  Toxicological sciences : an official journal of the Society of Toxicology 20111101

• Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.

  American journal of physiology. Cell physiology 20111101

• Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.

  American journal of physiology. Cell physiology 20111101

• Schisandra chinensis α-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages.

  International immunopharmacology 20111101

• Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1.

  Shock (Augusta, Ga.) 20111101

• Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.

  American journal of surgery 20111101

• Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of β-catenin and STAT1 in chronic myeloid leukemia cells.

  Journal of cellular physiology 20111101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase.

  Experimental & molecular medicine 20111031

• Activin A stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB pathways.

  Immunology letters 20111030

• Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis.

  The Journal of biological chemistry 20111021

• Cross-talk among intracellular signaling pathways mediates the diphenyl ditelluride actions on the hippocampal cytoskeleton of young rats.

  Chemical research in toxicology 20111017

• Differential adenosine uptake in mixed neuronal/glial or purified glial cultures of avian retinal cells: modulation by adenosine metabolism and the ERK cascade.

  Biochemical and biophysical research communications 20111014

• Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.

  Journal of ethnopharmacology 20111011

• Dapsone inhibits IL-8 secretion from human bronchial epithelial cells stimulated with lipopolysaccharide and resolves airway inflammation in the ferret.

  Chest 20111001

• Molecular changes induced by bisphenol-A in rat Sertoli cell culture.

  Systems biology in reproductive medicine 20111001

• p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation.

  Toxicology in vitro : an international journal published in association with BIBRA 20111001

• Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species.

  Toxicology in vitro : an international journal published in association with BIBRA 20111001

• Peroxisome proliferator-activated receptor γ (PPARγ) plays a critical role in the development of TGFβ resistance of H460 cell.

  Cellular signalling 20111001

• Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells.

  The Journal of pharmacology and experimental therapeutics 20111001

• Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments.

  The Journal of pharmacology and experimental therapeutics 20111001

• Angiotensin III stimulates ERK1/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes.

  Neuropeptides 20111001

• Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.

  Translational research : the journal of laboratory and clinical medicine 20111001

• Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance.

  The Journal of biological chemistry 20110923

• LC, a novel estrone-rhein hybrid compound, promotes proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells.

  Molecular and cellular endocrinology 20110915

• Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.

  British journal of pharmacology 20110901

• Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.

  British journal of pharmacology 20110901

• Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways.

  Journal of pineal research 20110901

• Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway.

  American journal of physiology. Cell physiology 20110901

• Effects of nonylphenol on the production of progesterone on the rats granulosa cells.

  Journal of cellular biochemistry 20110901

• Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.

  Toxicological sciences : an official journal of the Society of Toxicology 20110901

• Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells.

  Thrombosis and haemostasis 20110901

• Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.

  American journal of physiology. Cell physiology 20110901

• Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.

  Chemico-biological interactions 20110815

• Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815

• Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways.

  The Journal of surgical research 20110801

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

  American journal of respiratory cell and molecular biology 20110801

• Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.

  Journal of neuro-oncology 20110801

• Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801

• Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway.

  Journal of molecular endocrinology 20110801

• Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.

  American journal of physiology. Endocrinology and metabolism 20110801

• Defective nuclear translocation of stress-activated signaling in senescent diploid human fibroblasts: a possible explanation for aging-associated apoptosis resistance.

  Apoptosis : an international journal on programmed cell death 20110801

• Effects of downregulation of aquaporin1 by peptidoglycan and lipopolysaccharide via MAPK pathways in MeT-5A cells.

  Lung 20110801

• Insulin targets the Na(+)/K(+) ATPase in enterocytes via PI3K, PKC, and MAPKS.

  Journal of receptor and signal transduction research 20110801

• Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury.

  Anesthesiology 20110801

• Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.

  Molecular cancer research : MCR 20110801

• [Signal transduction pathway for TNF-induced IL-6 release from mast cells].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110801

• Induction of neurite-outgrowth in PC12 cells by alpha-toxin from Clostridium perfringens.

  Biochemical and biophysical research communications 20110729

• Dual blockade of phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.

  Cancer letters 20110728

• [Effect of Integrin α5β1-mediated ERK signal pathway on proliferation and migration of A549 cells].

  Zhongguo fei ai za zhi = Chinese journal of lung cancer 20110720

• Sulfur mustard induces differentiation in human primary keratinocytes: opposite roles of p38 and ERK1/2 MAPK.

  Toxicology letters 20110704

• Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury.

  Toxicology letters 20110704

• Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110701

• Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes.

  Molecular and cellular biochemistry 20110701

• Lipopolysaccharide stimulates syntheses of toll-like receptor 2 and surfactant protein-A in human alveolar epithelial A549 cells through upregulating phosphorylation of MEK1 and ERK1/2 and sequential activation of NF-κB.

  Cytokine 20110701

• mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.

  American journal of physiology. Cell physiology 20110701

• MEK inhibition suppresses the development of lung fibrosis in the bleomycin model.

  Naunyn-Schmiedeberg's archives of pharmacology 20110701

• Berberine acutely activates the glucose transport activity of GLUT1.

  Biochimie 20110701

• Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways.

  Biochimica et biophysica acta 20110601

• Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.

  Shock (Augusta, Ga.) 20110601

• Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes.

  Neuropharmacology 20110601

• Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3β signaling, and its knockdown results in deregulated G2/M transition in prostate cells.

  DNA and cell biology 20110601

• The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)].

  Biochemical pharmacology 20110601

• Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110601

• The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.

  Cytokine 20110601

• Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.

  Journal of dermatological science 20110601

• Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.

  Biochimica et biophysica acta 20110601

• Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.

  Journal of immunology (Baltimore, Md. : 1950) 20110601

• [Regulation of invasion behavior of ERK-mediated trophoblast by focal adhesion kinase].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110601

• [Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].

  Zhonghua fu chan ke za zhi 20110601

• Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression.

  Toxicology letters 20110530

• NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.

  Behavioural brain research 20110516

• Ubiquitous hazardous metal lead induces TNF-α in human phagocytic THP-1 cells: primary role of ERK 1/2.

  Journal of hazardous materials 20110515

• Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells.

  Journal of agricultural and food chemistry 20110511

• Proteomic analysis of human transplanted submandibular gland in patients with epiphora after transplantation.

  Journal of proteome research 20110506

• Growth hormone releasing hormone induces the expression of nitric oxide synthase.

  Journal of cellular and molecular medicine 20110501

• Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.

  Chemical biology & drug design 20110501

• Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling.

  Toxicological sciences : an official journal of the Society of Toxicology 20110501

• Pro-apoptotic role of integrin β3 in glioma cells.

  Journal of neurochemistry 20110501

• Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo.

  Apoptosis : an international journal on programmed cell death 20110501

• Impairment of oxidative stress-induced heme oxygenase-1 expression by the defect of Parkinson-related gene of PINK1.

  Journal of neurochemistry 20110501

• Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulated kinase in rat Leydig cells.

  Asian journal of andrology 20110501

• Genipa americana (Rubiaceae) fruit extract affects mitogen-activated protein kinase cell pathways in human trophoblast-derived BeWo cells: implications for placental development.

  Journal of medicinal food 20110501

• c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.

  Yonsei medical journal 20110501

• Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension.

  Bosnian journal of basic medical sciences 20110501

• The effects of BuYang HuanWu Decoction and its effective components on proliferation-related factors and ERK1/2 signal transduction pathway in cultured vascular smooth muscle cells.

  Journal of ethnopharmacology 20110426

• p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.

  The Journal of biological chemistry 20110415

• 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected].

  European journal of pharmacology 20110410

• Piceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cells through Sp1- and ERK-dependent DR5 up-regulation.

  Toxicology in vitro : an international journal published in association with BIBRA 20110401

• Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice.

  Pharmacology, biochemistry, and behavior 20110401

• Molecular regulation of NADPH oxidase 5 via the MAPK pathway.

  American journal of physiology. Heart and circulatory physiology 20110401

• Insulin-induced oxidative stress up-regulates heme oxygenase-1 via diverse signaling cascades in the C2 skeletal myoblast cell line.

  Endocrinology 20110401

• Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin.

  Diabetes 20110401

• 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562.

  Proteomics 20110401

• Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus.

  Learning & memory (Cold Spring Harbor, N.Y.) 20110401

• [Effects of ferulic acid on bFGF-treated PC12 cells].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

• Inhibitory effect of leptin on rosiglitazone-induced differentiation of primary adipocytes prepared from TallyHO/Jng mice.

  Biochemical and biophysical research communications 20110325

• Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.

  Bioorganic & medicinal chemistry 20110315

• C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.

  Journal of biochemistry 20110301

• Nicotinic stimulation of catecholamine synthesis and tyrosine hydroxylase phosphorylation in cervine adrenal medullary chromaffin cells.

  Journal of neuroendocrinology 20110301

• The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20110301

• Neoplastic alterations induced in mammalian skin following mancozeb exposure using in vivo and in vitro models.

  Omics : a journal of integrative biology 20110301

• A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.

  Journal of cellular and molecular medicine 20110201

• CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110201

• Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}.

  Cardiovascular research 20110201

• Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation.

  Anti-cancer drugs 20110201

• Suppression of human prostate cancer PC-3 cell growth by N-acetylcysteine involves over-expression of Cyr61.

  Toxicology in vitro : an international journal published in association with BIBRA 20110201

• Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production.

  Toxicology in vitro : an international journal published in association with BIBRA 20110201

• Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.

  Apoptosis : an international journal on programmed cell death 20110201

• Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.

  International journal of molecular medicine 20110201

• High glucose induces enhanced expression of resistin in human U937 monocyte-like cell line by MAPK- and NF-kB-dependent mechanisms; the modulating effect of insulin.

  Cell and tissue research 20110201

• Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells.

  Oncology reports 20110201

• C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110201

• The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro.

  International journal of cancer 20110115

• Nonlethal aluminum maltolate can reduce brain-derived neurotrophic factor-induced Arc expression through interrupting the ERK signaling in SH-SY5Y neuroblastoma cells.

  Toxicology letters 20110115

• Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.

  Toxicology 20110111

• Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.

  Biochemical and biophysical research communications 20110107

• Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.

  Circulation 20110104

• IL-29 and IFN-α regulate the expression of MxA, 2',5'-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells.

  Molecular biology reports 20110101

• Oxidative stress-induced attenuation of thrombospondin-1 expression in primary rat astrocytes.

  Journal of cellular biochemistry 20110101

• Estrogen receptor α36 mediates a bone-sparing effect of 17β-estrodiol in postmenopausal women.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110101

• Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure.

  Journal of molecular neuroscience : MN 20110101

• A trifluoromethyl analog of verbenachalcone promotes neurite outgrowth and cell proliferation of NeuroScreen-1 cells.

  Cellular and molecular neurobiology 20110101

• Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells.

  Environmental pollution (Barking, Essex : 1987) 20110101

• Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20110101

• Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.

  Toxicology and applied pharmacology 20110101

• Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20110101

• Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells.

  The Journal of endocrinology 20110101

• Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis.

  Arthritis and rheumatism 20110101

• Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death.

  Molecular immunology 20110101

• Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats.

  Molecular pain 20110101

• Protective effects of IGF-1 on neurons under condition of hypoxia and the role of PI3K signal pathway.

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110101

• Angiotensin II induces the expression of c-reactive protein via MAPK-dependent signal pathway in U937 macrophages.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Differential role for ERK2 in anoxia-induced activation of transcription and translation of Hsp70 in NIH 3T3 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• ERK is involved in the reorganization of somatosensory cortical maps in adult rats submitted to hindlimb unloading.

  PloS one 20110101

• All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.

  Cellular immunology 20110101

• Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.

  Archives of pharmacal research 20110101

• Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells.

  Molecular cancer 20110101

• CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

  Arthritis research & therapy 20110101

• Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.

  Drug metabolism and pharmacokinetics 20110101

• AGE-BSA down-regulates endothelial connexin43 gap junctions.

  BMC cell biology 20110101

• Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.

  Molecular pain 20110101

• Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells.

  Journal of neuroinflammation 20110101

• Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB.

  PloS one 20110101

• Thrombin preconditioning attenuates iron-induced neuronal death.

  Acta neurochirurgica. Supplement 20110101

• Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells.

  Molecular medicine reports 20110101

• Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.

  PloS one 20110101

• ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells.

  PloS one 20110101

• Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.

  PloS one 20110101

• Stretch-inducible expression of connective tissue growth factor (CTGF) in human osteoblasts-like cells is mediated by PI3K-JNK pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Panax notoginseng saponins promote osteogenic differentiation of bone marrow stromal cells through the ERK and P38 MAPK signaling pathways.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Effect of a chloride channel inhibitor, 5-nitro-2-(3-phenylpropylamino)-benzoate, on ovarian cancer cell migration.

  Clinical laboratory 20110101

• Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.

  BMC cancer 20110101

• On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.

  Molecular pain 20110101

• Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling.

  PloS one 20110101

• Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats.

  Molecular pain 20110101

• Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.

  BMC cancer 20110101

• Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages.

  Biological & pharmaceutical bulletin 20110101

• Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migration.

  PloS one 20110101

• Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways.

  Arthritis research & therapy 20110101

• Effect of benzo[a]pyrene on the production of vascular endothelial growth factor by human eosinophilic leukemia EoL-1 cells.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20110101

• C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.

  PloS one 20110101

• Inhibition of extracellular signal-regulated kinases ameliorates hypertension-induced renal vascular remodeling in rat models.

  International journal of molecular sciences 20110101

• Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species.

  European journal of pharmacology 20101215

• Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.

  Journal of cellular biochemistry 20101215

• Insulin stimulates gene expression of ferritin light chain in osteoblast cells.

  Journal of cellular biochemistry 20101215

• Parathyroid hormone(1-34)-induced apoptosis in neuronal rat PC12 cells: implications for neurotoxicity.

  Pathology, research and practice 20101215

• An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs.

  Oncogene 20101209

• Heme oxygenase-1 signals are involved in preferential inhibition of pro-inflammatory cytokine release by surfactin in cells activated with Porphyromonas gingivalis lipopolysaccharide.

  Chemico-biological interactions 20101205

• Resveratrol restores lysophosphatidylcholine-induced loss of endothelium-dependent relaxation in rat aorta tissue coinciding with inhibition of extracellular-signal-regulated protein kinase activation.

  Phytotherapy research : PTR 20101201

• Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells.

  Tissue engineering. Part A 20101201

• Cell cycle events mediate lactacystin-induced apoptotic death of neuronal PC12 cells.

  Cell biology international 20101201

• Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.

  Arthritis and rheumatism 20101201

• Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes.

  Atherosclerosis 20101201

• Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101201

• Inhibitory effects of epidermal growth factor on progesterone production of ovarian granulosa cells in Tsaiya duck (Anas platyrhynchos var. domestica).

  British poultry science 20101201

• [ERK1/2 mediates edaravone-triggered protection against myocardial damage induced by isoprenaline in H9c2 cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101201

• Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells.

  Anticancer research 20101201

• Parathyroid hormone-mitogen-activated protein kinase axis exerts fibrogenic effect of connective tissue growth factor on human renal proximal tubular cells.

  Chinese medical journal 20101201

• The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment.

  Blood 20101125

• Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase.

  The Journal of biological chemistry 20101112

• Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells.

  Brain research 20101111

• Gefitinib enhances arsenic trioxide (AS2O3)-induced differentiation of acute promyelocytic leukemia cell line.

  Leukemia research 20101101

• Resveratrol modulates angiogenesis through the GSK3β/β-catenin/TCF-dependent pathway in human endothelial cells.

  Biochemical pharmacology 20101101

• Signaling of extracellular inorganic phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway.

  Bone 20101101

• NMDA receptor, PKC and ERK prevent fos expression induced by the activation of group I metabotropic glutamate receptors in the spinal trigeminal subnucleus oralis.

  Molecules and cells 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Inhibition of the mammalian target of rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells.

  Autophagy 20101101

• The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

  Toxicology letters 20101020

• Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression.

  Toxicology letters 20101005

• Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.

  Biochemistry 20101005

• Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.

  The Journal of pharmacology and experimental therapeutics 20101001

• Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• MCP-1 production in temporomandibular joint inflammation.

  Journal of dental research 20101001

• Calcitonin gene-related peptide as a regulator of neuronal CaMKII-CREB, microglial p38-NFκB and astroglial ERK-Stat1/3 cascades mediating the development of tolerance to morphine-induced analgesia.

  Pain 20101001

• ZmMPK5 is required for the NADPH oxidase-mediated self-propagation of apoplastic H2O2 in brassinosteroid-induced antioxidant defence in leaves of maize.

  Journal of experimental botany 20101001

• A methyl jasmonate derivative, J-7, induces apoptosis in human hepatocarcinoma Hep3B cells in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.

  Oral diseases 20101001

• Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways.

  Cancer letters 20100928

• ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma.

  Cancer biology & therapy 20100915

• Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100911

• Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest.

  Cell death and differentiation 20100901

• Imipramine-induced cardiac depression is responsible for the increase in intracellular magnesium and the activation of ERK 1/2 in rats.

  Journal of cardiovascular pharmacology and therapeutics 20100901

• Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery.

  Toxicology letters 20100901

• Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase.

  International immunopharmacology 20100901

• Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.

  Toxicology and applied pharmacology 20100901

• Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action.

  European journal of cell biology 20100901

• Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.

  Molecular endocrinology (Baltimore, Md.) 20100901

• Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells.

  Leukemia & lymphoma 20100901

• Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells.

  Acta biochimica et biophysica Sinica 20100901

• Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.

  European journal of pharmacology 20100825

• Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.

  Toxicology and applied pharmacology 20100815

• Cellular mechanisms of long-term depression induced by noradrenaline in rat prefrontal neurons.

  Neuroscience 20100811

• Pyrogallol-induced As4.1 juxtaglomerular cell death is attenuated by MAPK inhibitors via preventing GSH depletion.

  Archives of toxicology 20100801

• Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.

  Journal of periodontal research 20100801

• Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.

  Free radical biology & medicine 20100801

• Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells.

  International immunopharmacology 20100801

• Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma.

  Archives of toxicology 20100801

• Regulation of placental leptin expression by cyclic adenosine 5'-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways.

  Endocrinology 20100801

• Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

  British journal of pharmacology 20100801

• Release of interleukin-1 receptor antagonist by combining a leukocyte adsorption carrier with ulinastatin.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20100801

• Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines.

  Neoplasia (New York, N.Y.) 20100801

• The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer.

  The Journal of biological chemistry 20100730

• Mechanisms of hepatocyte growth factor-mediated signaling in differentiation of pancreatic ductal epithelial cells into insulin-producing cells.

  Biochemical and biophysical research communications 20100730

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  Cell biology international 20090901

• Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism.

  Toxicology in vitro : an international journal published in association with BIBRA 20090901

• Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.

  Hepatology (Baltimore, Md.) 20090901

• A(1) adenosine receptor-mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells.

  American journal of physiology. Heart and circulatory physiology 20090901

• Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.

  Archives of biochemistry and biophysics 20090901

• Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.

  Annals of the New York Academy of Sciences 20090901

• Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes.

  International journal of cardiology 20090821

• Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.

  The Journal of biological chemistry 20090821

• Stretch-induced ERK2 phosphorylation requires PLA2 activity in skeletal myotubes.

  Biochemical and biophysical research communications 20090814

• Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.

  Toxicology letters 20090810

• P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo.

  Glia 20090801

• Pleiotropic effects of cadmium in mesangial cells.

  Toxicology and applied pharmacology 20090801

• Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090801

• The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.

  International immunopharmacology 20090801

• Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells.

  Journal of periodontal research 20090801

• PPARgamma agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway.

  Laboratory investigation; a journal of technical methods and pathology 20090801

• Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.

  The Journal of endocrinology 20090801

• Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.

  American journal of physiology. Renal physiology 20090801

• Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells.

  Archives of oral biology 20090801

• Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways.

  Journal of pineal research 20090801

• Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.

  American journal of physiology. Heart and circulatory physiology 20090801

• Differential inhibition of single and cluster type tumor cell migration.

  Anticancer research 20090801

• Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.

  Annals of the New York Academy of Sciences 20090801

• Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.

  Molecules and cells 20090731

• 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.

  Archives of biochemistry and biophysics 20090715

• Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells.

  Toxicology 20090710

• Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells.

  Gastroenterology 20090701

• Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes.

  Molecular and cellular biochemistry 20090701

• Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle.

  Biochimie 20090701

• Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.

  Carcinogenesis 20090701

• Positive feedback regulation of maize NADPH oxidase by mitogen-activated protein kinase cascade in abscisic acid signalling.

  Journal of experimental botany 20090701

• Receptor-mediated vascular smooth muscle migration induced by LPA involves p38 mitogen-activated protein kinase pathway activation.

  International journal of molecular sciences 20090701

• NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells.

  Toxicology letters 20090622

• Interplay between MEK and PI3 kinase signaling regulates the subcellular localization of protein kinases ERK1/2 and Akt upon oxidative stress.

  FEBS letters 20090618

• Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.

  Toxicology and applied pharmacology 20090615

• Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.

  Toxicology and applied pharmacology 20090615

• Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.

  Cell cycle (Georgetown, Tex.) 20090615

• Intracellular signaling pathways involved in inhibition of PAI-1 expression by CNP in endothelial cells.

  Regulatory peptides 20090605

• Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.

  Fertility and sterility 20090601

• Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization.

  Molecular carcinogenesis 20090601

• Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway.

  Lung cancer (Amsterdam, Netherlands) 20090601

• Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK.

  American journal of physiology. Heart and circulatory physiology 20090601

• Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.

  Journal of molecular and cellular cardiology 20090601

• Urotensin II induces transactivation of the epidermal growth factor receptor via transient oxidation of SHP-2 in the rat renal tubular cell line NRK-52E.

  Growth factors (Chur, Switzerland) 20090601

• The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.

  American journal of physiology. Heart and circulatory physiology 20090601

• Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer.

  Cytokine 20090601

• Apelin protects heart against ischemia/reperfusion injury in rat.

  Peptides 20090601

• The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity.

  Bipolar disorders 20090601

• Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.

  Journal of genetics and genomics = Yi chuan xue bao 20090601

• Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.

  Journal of immunotoxicology 20090601

• Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells.

  Life sciences 20090522

• 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway.

  Chemico-biological interactions 20090515

• Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.

  Chemico-biological interactions 20090515

• Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells.

  Neuroreport 20090506

• The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons.

  The Journal of pharmacology and experimental therapeutics 20090501

• Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose.

  American journal of physiology. Endocrinology and metabolism 20090501

• Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis.

  European journal of pharmacology 20090501

• ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

  American journal of physiology. Heart and circulatory physiology 20090501

• Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

  American journal of physiology. Heart and circulatory physiology 20090501

• Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca2+ channel expression in neonatal rat cardiomyocytes.

  European journal of pharmacology 20090501

• Role of ERK/mTOR signaling in TGFbeta-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells.

  Cell and tissue research 20090501

• 17beta-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts.

  The journal of physiological sciences : JPS 20090501

• CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK.

  British journal of haematology 20090501

• Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: pivotal roles of NF-kappaB and MAPK.

  Pharmacological research 20090501

• Common carp (Cyprinus carpio) insulin-like growth factor binding protein-2 (IGFBP-2): molecular cloning, expression profiles, and hormonal regulation in hepatocytes.

  General and comparative endocrinology 20090501

• Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells.

  Oncogene 20090430

• Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases.

  Journal of ethnopharmacology 20090421

• Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090415

• A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells.

  Endocrinology 20090401

• CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.

  Investigative ophthalmology & visual science 20090401

• Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• IL-10 attenuates TNF-alpha-induced NF kappaB pathway activation and cardiomyocyte apoptosis.

  Cardiovascular research 20090401

• TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways.

  Respirology (Carlton, Vic.) 20090401

• Fibrinogen-induced endothelin-1 production from endothelial cells.

  American journal of physiology. Cell physiology 20090401

• Advanced glycation end products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells.

  International journal of molecular medicine 20090401

• Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts.

  International journal of molecular medicine 20090401

• Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells.

  British journal of pharmacology 20090401

• Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase.

  Archives of dermatological research 20090401

• 15-Deoxy-Delta-Prostaglandin J(2) Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats.

  Immune network 20090401

• Molecular events in the activation of B cells and macrophages by a non-microbial TLR4 agonist, G1-4A from Tinospora cordifolia.

  Immunology letters 20090324

• Nitric oxide and ERK/MAPK mediation of estrous behavior induced by GnRH, PGE2 and db-cAMP in rats.

  Physiology & behavior 20090323

• Role of mitogen-activated protein kinase cascades in inducible nitric oxide synthase expression by lipopolysaccharide in a rat Schwann cell line.

  Neurochemical research 20090301

• Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells.

  Nitric oxide : biology and chemistry 20090301

• BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK.

  Neurobiology of learning and memory 20090301

• The role of p44/42 activation in tributyltin-induced inhibition of human natural killer cells: effects of MEK inhibitors.

  Journal of applied toxicology : JAT 20090301

• Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation.

  Investigative ophthalmology & visual science 20090301

• Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-kappaB pathways.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling.

  Microvascular research 20090301

• Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.

  Journal of molecular and cellular cardiology 20090301

• Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway.

  Toxicology and applied pharmacology 20090301

• Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• Vitisin A suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-kappaB activation in RAW 264.7 cells.

  International immunopharmacology 20090301

• Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer.

  Cancer investigation 20090301

• Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS.

  Environmental health perspectives 20090301

• Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk.

  Neuroscience research 20090301

• GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling.

  Anti-cancer drugs 20090301

• Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation.

  Amino acids 20090201

• Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.

  The Journal of reproduction and development 20090201

• ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells.

  Free radical biology & medicine 20090201

• Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy.

  Molecular and cellular biochemistry 20090201

• Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells.

  Alcoholism, clinical and experimental research 20090201

• Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation.

  Biochemical pharmacology 20090201

• Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats.

  The journal of pain : official journal of the American Pain Society 20090201

• Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.

  American journal of physiology. Gastrointestinal and liver physiology 20090201

• Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells.

  Carcinogenesis 20090201

• Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage.

  Surgery 20090201

• [Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20090201

• The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway.

  Neuroscience letters 20090123

• Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells.

  FEBS letters 20090105

• Up-regulation of placental leptin by human chorionic gonadotropin.

  Endocrinology 20090101

• BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels.

  Cellular signalling 20090101

• Src activity alters alpha3 integrin expression in colon tumor cells.

  Clinical & experimental metastasis 20090101

• AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.

  Virus research 20090101

• Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons.

  Neuroendocrinology 20090101

• FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast.

  Archives of biochemistry and biophysics 20090101

• Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.

  Molecular cancer therapeutics 20090101

• Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells.

  Immunobiology 20090101

• Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.

  Autonomic & autacoid pharmacology 20090101

• ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells.

  Cellular immunology 20090101

• Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells.

  Anticancer research 20090101

• PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells.

  Anti-cancer drugs 20090101

• Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors.

  Annals of clinical and laboratory science 20090101

• Tgf-beta auto-induction and connective tissue growth factor expression in human renal tubule epithelial cells requires N-ras.

  Nephron. Experimental nephrology 20090101

• Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.

  BMC cancer 20090101

• Cytoplasm-to-nucleus shuttling of thyroid hormone receptor-beta1 (Trbeta1) is directed from a plasma membrane integrin receptor by thyroid hormone.

  Endocrine research 20090101

• Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.

  Arthritis research & therapy 20090101

• Leptin interferes with 3',5'-cyclic adenosine monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells.

  Reproductive biology and endocrinology : RB&E 20090101

• Dissecting the signaling events that impact classical nuclear import and target nuclear transport factors.

  PloS one 20090101

• Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice.

  International journal of immunopathology and pharmacology 20090101

• Risk assessment of hydroquinone: differential responses of cell growth and lethality correlated to hydroquinone concentration.

  Journal of toxicology and environmental health. Part A 20090101

• Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression.

  Experimental & molecular medicine 20081231

• Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.

  Experimental & molecular medicine 20081231

• TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons.

  Biochemical and biophysical research communications 20081226

• A role for IL-18 in human neutrophil apoptosis.

  Shock (Augusta, Ga.) 20081201

• Insulin enhancement of cytokine-induced coagulation/inflammation-related gene transcription in hepatocytes.

  Endocrine journal 20081201

• The effect of serotonin on GABA synthesis in cultured rat spinal dorsal horn neurons.

  Journal of chemical neuroanatomy 20081201

• Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways.

  Toxicological sciences : an official journal of the Society of Toxicology 20081201

• Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells.

  Cell biology international 20081201

• Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells.

  Toxicology and applied pharmacology 20081201

• o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.

  Toxicology and applied pharmacology 20081201

• Regulation of ACE2 in cardiac myocytes and fibroblasts.

  American journal of physiology. Heart and circulatory physiology 20081201

• Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells.

  Journal of neurochemistry 20081201

• Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes.

  Metabolism: clinical and experimental 20081201

• Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells.

  Acta pharmacologica Sinica 20081201

• Antagonists of the protein kinase A and mitogen-activated protein kinase systems and of the progestin receptor block the ability of vaginocervical/flank-perineal stimulation to induce female rat sexual behaviour.

  Journal of neuroendocrinology 20081201

• High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells.

  Thrombosis and haemostasis 20081201

• Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes.

  Zebrafish 20081201

• Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.

  Journal of endocrinological investigation 20081201

• Enhanced proliferation of SNU-407 human colon cancer cells by muscarinic acetylcholine receptors.

  BMB reports 20081130

• Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.

  FEBS letters 20081126

• Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes.

  Experimental cell research 20081115

• Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.

  The Journal of comparative neurology 20081110

• Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.

  Cancer letters 20081108

• Leptin inhibits rosiglitazone-induced adipogenesis in murine primary adipocytes.

  Molecular and cellular endocrinology 20081106

• Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.

  Journal of cellular physiology 20081101

• Identification of intracellular signaling cascades mediating the PACAP-induced increase in guinea pig cardiac neuron excitability.

  Journal of molecular neuroscience : MN 20081101

• IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.

  Journal of cellular physiology 20081101

• Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition.

  Gut 20081101

• In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/eicosapentaenoic acid combinations and their simultaneous delivery across skin.

  Pharmaceutical research 20081101

• The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion.

  Molecular and cellular biochemistry 20081101

• Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.

  Peptides 20081101

• PAR2 exerts local protection against acute pancreatitis via modulation of MAP kinase and MAP kinase phosphatase signaling.

  American journal of physiology. Gastrointestinal and liver physiology 20081101

• MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides.

  American journal of physiology. Cell physiology 20081101

• ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20081101

• Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy.

  Alcoholism, clinical and experimental research 20081101

• IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

  Rheumatology (Oxford, England) 20081101

• Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling.

  The Journal of steroid biochemistry and molecular biology 20081101

• Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway.

  Cellular and molecular life sciences : CMLS 20081101

• Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues.

  Spine 20081101

• Involvement of epigenetic mechanisms in the regulation of secreted phospholipase A2 expressions in Jurkat leukemia cells.

  Neoplasia (New York, N.Y.) 20081101

• Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow.

  American journal of surgery 20081101

• [Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].

  Ai zheng = Aizheng = Chinese journal of cancer 20081101

• IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells.

  Immunology letters 20081030

• Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.

  Neuroscience 20081015

• Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.

  The Journal of biological chemistry 20081010

• Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.

  Cancer chemotherapy and pharmacology 20081001

• Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells.

  Cell biology and toxicology 20081001

• Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction.

  Journal of pineal research 20081001

• Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals.

  Carcinogenesis 20081001

• Effects of peroxisome proliferator-activated receptor alpha (PPARalpha) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells.

  Biochimica et biophysica acta 20081001

• TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.

  Cancer investigation 20081001

• Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.

  Biochimica et biophysica acta 20081001

• Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation.

  Journal of leukocyte biology 20081001

• The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

  Molecular pharmacology 20081001

• Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo.

  Experimental biology and medicine (Maywood, N.J.) 20081001

• Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons.

  Histochemistry and cell biology 20081001

• Pulsatile mechanical pressure promotes Angiotensin-converting enzyme expression in aortic smooth muscle cells.

  Cardiovascular drugs and therapy 20081001

• Leptin protects hippocampal CA1 neurons against ischemic injury.

  Journal of neurochemistry 20081001

• PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.

  Placenta 20081001

• Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway.

  Cytokine 20081001

• Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.

  Biochemical and biophysical research communications 20080926

• Vincristine attenuates doxorubicin cardiotoxicity.

  Biochemical and biophysical research communications 20080905

• The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.

  Oral oncology 20080901

• Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression.

  Carcinogenesis 20080901

• Methyl-beta-cyclodextrin, a specific cholesterol-binding agent, inhibits melanogenesis in human melanocytes through activation of ERK.

  Archives of dermatological research 20080901

• Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.

  The Journal of endocrinology 20080901

• Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis.

  The Journal of clinical endocrinology and metabolism 20080901

• Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling.

  The Journal of pharmacology and experimental therapeutics 20080901

• Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.

  Carcinogenesis 20080901

• Ras-mediated up-regulation of survivin expression in cytokine-dependent murine pro-B lymphocytic cells.

  The Tohoku journal of experimental medicine 20080901

• [Effect of extracellular signal regulated kinase signal pathway on apoptosis induced by MG262 in ovarian cancer cells].

  Zhonghua fu chan ke za zhi 20080901

• Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment.

  European journal of pharmacology 20080820

• Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells.

  Journal of cellular biochemistry 20080815

• Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.

  Neuroscience letters 20080808

• In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.

  Digestive diseases and sciences 20080801

• Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.

  The Journal of investigative dermatology 20080801

• A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801

• Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080801

• Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase.

  Molecular pharmacology 20080801

• Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.

  The Biochemical journal 20080801

• Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.

  Human reproduction (Oxford, England) 20080801

• Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.

  Diabetes 20080801

• PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.

  Kidney international 20080801

• AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast.

  Bone 20080801

• MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.

  American journal of physiology. Cell physiology 20080801

• Angiotensin II-triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats.

  Hypertension (Dallas, Tex. : 1979) 20080801

• Aqueous humor outflow effects of 2-arachidonylglycerol.

  Experimental eye research 20080801

• Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases.

  Oncology reports 20080801

• Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways.

  Innate immunity 20080801

• Ligation of CD44 leads to killing activity in human peripheral mononuclear cells via MAP kinase and tyrosine kinases.

  Hematology (Amsterdam, Netherlands) 20080801

• Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5.

  Hematology (Amsterdam, Netherlands) 20080801

• Effect of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells.

  The journal of medical investigation : JMI 20080801

• Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.

  European journal of pharmacology 20080728

• Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2.

  British journal of cancer 20080722

• Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.

  Biochemical and biophysical research communications 20080718

• Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes.

  Biochemical and biophysical research communications 20080711

• Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A.

  Leukemia research 20080701

• The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death.

  Experimental physiology 20080701

• Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.

  Journal of leukocyte biology 20080701

• Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.

  Domestic animal endocrinology 20080701

• Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the generation of reactive oxygen species.

  Endocrinology 20080701

• De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells.

  Archives of biochemistry and biophysics 20080701

• Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation.

  The Journal of pharmacology and experimental therapeutics 20080701

• PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059.

  The Journal of endocrinology 20080701

• HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.

  Archives of biochemistry and biophysics 20080701

• Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK.

  Neurotoxicology 20080701

• Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone.

  Biochemical and biophysical research communications 20080627

• The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK.

  Journal of ethnopharmacology 20080619

• FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1.

  Molecular carcinogenesis 20080601

• Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.

  Leukemia research 20080601

• Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts.

  Toxicological sciences : an official journal of the Society of Toxicology 20080601

• Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells.

  The Journal of pharmacology and experimental therapeutics 20080601

• Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.

  Biochimica et biophysica acta 20080601

• Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells.

  Molecular pharmacology 20080601

• Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes.

  Journal of cellular physiology 20080601

• Estrogen and the Ca2+-mobilizing agonist ATP evoke acute NO synthesis via distinct pathways in an individual human vascular endothelium-derived cell.

  American journal of physiology. Cell physiology 20080601

• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3'K and ERK1/2 MAPK signal transduction pathways.

  Cellular signalling 20080601

• Hormonal regulation of regucalcin mRNA expression in osteoblastic MC3T3-E1 cells.

  International journal of molecular medicine 20080601

• Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.

  Archives of pharmacal research 20080601

• Interleukin-6 stimulates lipolysis in porcine adipocytes.

  Endocrine 20080601

• A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.

  The Journal of biological chemistry 20080523

• MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.

  Toxicology 20080521

• [Effects of astragalus injection on extracellular signal-regulated kinase pathway in cultured normal cardiac myocytes].

  Zhonghua yi xue za zhi 20080520

• The nitric oxide-sensitive p21Ras-ERK pathway mediates S-nitrosoglutathione-induced apoptosis.

  Biochemical and biophysical research communications 20080516

• Glyoxal causes inflammatory injury in human vascular endothelial cells.

  Biochemical and biophysical research communications 20080516

• Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway.

  Biochemical pharmacology 20080515

• Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells.

  The Journal of nutritional biochemistry 20080501

• Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule.

  Journal of applied toxicology : JAT 20080501

• Mifepristone attenuates human chorionic gonadotropin-induced extracellular signal-regulated kinase 1/2 phosphorylation, cyclooxygenase-2, and prostaglandin E2 production in human granulosa luteal cells.

  Fertility and sterility 20080501

• IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway.

  The Journal of investigative dermatology 20080501

• Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model.

  The Journal of investigative dermatology 20080501

• Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.

  American journal of physiology. Heart and circulatory physiology 20080501

• Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts.

  Bone 20080501

• Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.

  Laboratory investigation; a journal of technical methods and pathology 20080501

• [Parathyroid hormone 1-34 induce cardiac myocytes hypertrophy via extracellular regulated protein kinase 1/2 pathway].

  Zhonghua xin xue guan bing za zhi 20080501

• NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis.

  Toxicology 20080418

• Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.

  Toxicology 20080418

• 1-Bromopropane induces macrophage activation via extracellular signal-regulated kinase 1/2 MAPK and NF-κB pathways.

  Cancer letters 20080408

• Tumour necrosis factor-alpha-mediated human polymeric immunoglobulin receptor expression is regulated by both mitogen-activated protein kinase and phosphatidylinositol-3-kinase in HT-29 cell line.

  Immunology 20080401

• Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

  American journal of respiratory cell and molecular biology 20080401

• Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury.

  The Journal of pharmacology and experimental therapeutics 20080401

• Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.

  Autophagy 20080401

• The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK.

  The Prostate 20080401

• Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 Cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.

  Journal of proteome research 20080401

• Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.

  Cell proliferation 20080401

• Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.

  Gastroenterology 20080401

• Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.

  European journal of pharmacology 20080317

• Insulin signaling stimulates insulin transport by bovine aortic endothelial cells.

  Diabetes 20080301

• Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells.

  Bone 20080301

• Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells.

  FEMS immunology and medical microbiology 20080301

• Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells.

  Life sciences 20080227

• Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium.

  Life sciences 20080227

• Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.

  The Journal of biological chemistry 20080222

• Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

  Free radical biology & medicine 20080215

• Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension.

  Life sciences 20080213

• Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts.

  European journal of pharmacology 20080212

• Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.

  Journal of cellular biochemistry 20080201

• Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling.

  Journal of cellular physiology 20080201

• Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling.

  British journal of pharmacology 20080201

• Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.

  American journal of respiratory and critical care medicine 20080201

• The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.

  American journal of physiology. Renal physiology 20080201

• Effects of the marine toxins okadaic acid and palytoxin on mussel phagocytosis.

  Fish & shellfish immunology 20080201

• Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.

  American journal of physiology. Heart and circulatory physiology 20080201

• Resveratrol reverses hydrogen peroxide-induced proliferative effects in human coronary smooth muscle cells: a novel signaling mechanism.

  Archives of medical research 20080201

• Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell.

  Cancer investigation 20080201

• An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20080201

• Leptin stimulates pituitary prolactin release through an extracellular signal-regulated kinase-dependent pathway.

  The Journal of endocrinology 20080201

• Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism.

  The Journal of endocrinology 20080201

• Brain derived neurotrophic factor induces endothelial cells angiogenesis through AKT and ERK1/2 signal pathway.

  Zhongguo shi yan xue ye xue za zhi 20080201

• Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.

  Biomedical research (Tokyo, Japan) 20080201

• Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells.

  Chemico-biological interactions 20080130

• Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts.

  European journal of pharmacology 20080128

• [The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment].

  Zhonghua yi xue za zhi 20080122

• Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation.

  Chemico-biological interactions 20080110

• Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK.

  The Journal of biological chemistry 20080104

• Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.

  Journal of the National Cancer Institute 20080102

• Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.

  Pflugers Archiv : European journal of physiology 20080101

• Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

• A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription.

  Neurobiology of disease 20080101

• MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.

  The Biochemical journal 20080101

• Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation.

  Biology of reproduction 20080101

• Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.

  The Journal of pharmacology and experimental therapeutics 20080101

• FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade.

  Molecular pharmacology 20080101

• Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage.

  The Journal of pharmacology and experimental therapeutics 20080101

• STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.

  American journal of physiology. Gastrointestinal and liver physiology 20080101

• Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.

  Experimental hematology 20080101

• Calcium influxes and mitogen-activated protein kinase kinase activation mediate ethylene inducing ipomoelin gene expression in sweet potato.

  Plant, cell & environment 20080101

• Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes.

  Basic & clinical pharmacology & toxicology 20080101

• Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.

  Carcinogenesis 20080101

• Unique MAP Kinase binding sites.

  Biochimica et biophysica acta 20080101

• The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.

  European journal of heart failure 20080101

• High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities.

  The Journal of endocrinology 20080101

• A possible impaired signaling mechanism in human retinal pigment epithelial cells from patients with macular degeneration.

  Advances in experimental medicine and biology 20080101

• BDNF increases the phagocytic activity in cultured iris pigment epithelial cells.

  Cell structure and function 20080101

• Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.

  The international journal of biochemistry & cell biology 20080101

• Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins.

  International archives of allergy and immunology 20080101

• Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene.

  Breast cancer research : BCR 20080101

• A prenylation inhibitor (sodium phenylacetate) differently affects MCF-7 cell death when ras is overexpressed, partly involving P42/44, JNK and P38 kinase activations.

  Anticancer research 20080101

• COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells.

  Biochimica et biophysica acta 20080101

• Mechanical stress upregulates intercellular adhesion molecule-1 in pulmonary epithelial cells.

  Respiration; international review of thoracic diseases 20080101

• Jab1 is a target of EGFR signaling in ERalpha-negative breast cancer.

  Breast cancer research : BCR 20080101

• HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study.

  BMC infectious diseases 20080101

• Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.

  Journal of bone and mineral metabolism 20080101

• The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.

  Neuroendocrinology 20080101

• RET activation inhibits doxorubicin-induced apoptosis in SK-N-MC cells.

  Anticancer research 20080101

• Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma.

  Tumori 20080101

• The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.

  BMC cancer 20080101

• Rat parathyroid hormone 1-34 signals through the MEK/ERK pathway to induce cardiac hypertrophy.

  The Journal of international medical research 20080101

• The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts.

  Journal of bone and mineral metabolism 20080101

• Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells.

  Journal of nephrology 20080101

• Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells.

  Arthritis research & therapy 20080101

• ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells.

  European journal of pharmacology 20071222

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.

  Cancer research 20071215

• Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation.

  Biochemical and biophysical research communications 20071214

• Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.

  Journal of cellular biochemistry 20071201

• Chromatin compaction and cell death by high molecular weight FGF-2 depend on its nuclear localization, intracrine ERK activation, and engagement of mitochondria.

  Journal of cellular physiology 20071201

• MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

• Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20071201

• p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis.

  American journal of physiology. Heart and circulatory physiology 20071201

• SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent I CaL, [Ca2+]i transient, and APD increase in cardiomyocytes.

  Journal of molecular and cellular cardiology 20071201

• The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.

  Cancer research 20071201

• Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.

  Journal of pharmacological sciences 20071201

• [Synergistic effect of rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20071201

• Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells.

  Biochemical and biophysical research communications 20071123

• Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling.

  The Journal of biological chemistry 20071123

• Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.

  European journal of pharmacology 20071114

• Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.

  European journal of pharmacology 20071114

• Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.

  European journal of pharmacology 20071114

• Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes.

  European journal of pharmacology 20071114

• Molecular mechanism of molt-inhibiting hormone (MIH) induced suppression of ecdysteroidogenesis in the Y-organ of mud crab: Scylla serrata.

  FEBS letters 20071113

• Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.

  Atherosclerosis 20071101

• Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.

  Neurochemical research 20071101

• Alpha2-adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner.

  Journal of neurochemistry 20071101

• Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.

  Toxicological sciences : an official journal of the Society of Toxicology 20071101

• Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.

  American journal of physiology. Renal physiology 20071101

• Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells.

  The Journal of pharmacology and experimental therapeutics 20071101

• Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.

  Molecular and cellular neurosciences 20071101

• Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway.

  American journal of physiology. Cell physiology 20071101

• Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine.

  Pediatric research 20071101

• Apoptotic effects of signal transduction inhibitors on human tumor cells with different PTEN expression.

  Oncology reports 20071101

• Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.

  Biochimica et biophysica acta 20071101

• The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

  Cancer research 20071101

• Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells.

  The European journal of neuroscience 20071101

• Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.

  Life sciences 20071027

• Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration.

  The Journal of biological chemistry 20071019

• Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells.

  The Journal of biological chemistry 20071012

• Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages.

  Journal of cellular biochemistry 20071001

• Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.

  Journal of cellular biochemistry 20071001

• Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha.

  American journal of physiology. Heart and circulatory physiology 20071001

• Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.

  Immunology and cell biology 20071001

• Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity.

  American journal of physiology. Cell physiology 20071001

• Patterns of kinase activation induced by injury in the murine femoral artery.

  The Journal of surgical research 20071001

• Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.

  Steroids 20071001

• The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer.

  Cancer research 20071001

• Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.

  Toxicology 20070905

• D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium.

  Journal of cellular physiology 20070901

• Prostacyclin inhibits endothelial cell XIAP ubiquitination and degradation.

  Journal of cellular physiology 20070901

• IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.

  Journal of cellular physiology 20070901

• Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.

  Journal of cellular physiology 20070901

• High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway.

  The Journal of pharmacology and experimental therapeutics 20070901

• Extracellular calcium-sensing receptor is functionally expressed in human artery.

  American journal of physiology. Renal physiology 20070901

• COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity.

  Journal of neurochemistry 20070901

• Expression and function of protein phosphatase PP2A in malignant testicular germ cell tumours.

  The Journal of pathology 20070901

• Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells.

  Toxicology and applied pharmacology 20070901

• The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways.

  American journal of physiology. Heart and circulatory physiology 20070901

• Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.

  Anti-cancer drugs 20070901

• Evidence for the regulation of contraction-induced fatty acid oxidation via extracellular signal-regulated kinase 1/2 activation independent of changes in fatty acid uptake.

  Metabolism: clinical and experimental 20070901

• Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo.

  Anesthesia and analgesia 20070901

• Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.

  Investigative ophthalmology & visual science 20070901

• Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.

  Peptides 20070901

• Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.

  Journal of pharmacological sciences 20070901

• p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells.

  Journal of pharmacological sciences 20070901

• Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.

  Experimental & molecular medicine 20070831

• PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor.

  Journal of cellular biochemistry 20070815

• Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance.

  Experimental cell research 20070815

• Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20070815

• Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction.

  European journal of pharmacology 20070813

• Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells.

  Archives of oral biology 20070801

• Modulation of tight junction barrier function by outer membrane proteins of enteropathogenic Escherichia coli: role of F-actin and junctional adhesion molecule-1.

  Cell biology international 20070801

• Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.

  Journal of hepatology 20070801

• High-content classification of nucleocytoplasmic import or export inhibitors.

  Journal of biomolecular screening 20070801

• Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cells.

  Endocrinology 20070801

• Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.

  Human reproduction (Oxford, England) 20070801

• Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20070801

• Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms.

  Journal of molecular and cellular cardiology 20070801

• Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.

  International immunopharmacology 20070801

• 6-Hydroxydopamine induces mitochondrial ERK activation.

  Free radical biology & medicine 20070801

• The mitogen-activated protein kinase pathway tonically inhibits both basal and IGF-I-stimulated IGF-binding protein-5 production in mammary epithelial cells.

  The Journal of endocrinology 20070801

• Effects of extracellular signal-regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde.

  Journal of digestive diseases 20070801

• Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.

  Pathology 20070801

• Differential responses of human papillary thyroid cancer cell lines carrying the RET/PTC1 rearrangement or a BRAF mutation to MEK1/2 inhibitors.

  Archives of otolaryngology--head & neck surgery 20070801

• PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.

  The European journal of neuroscience 20070801

• Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.

  The Journal of biological chemistry 20070720

• Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.

  The Biochemical journal 20070715

• NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes.

  Cardiovascular research 20070715

• High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1/2.

  Molecular and cellular biochemistry 20070701

• Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.

  Pflugers Archiv : European journal of physiology 20070701

• HGF ameliorates a high-fat diet-induced fatty liver.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.

  Endocrinology 20070701

• Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism.

  American journal of physiology. Lung cellular and molecular physiology 20070701

• Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway.

  British journal of pharmacology 20070701

• Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression.

  Biochimica et biophysica acta 20070701

• IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.

  The Journal of endocrinology 20070701

• Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling.

  Molecular and cellular endocrinology 20070615

• Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.

  Oncogene 20070607

• Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.

  Journal of cellular biochemistry 20070601

• Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.

  American journal of physiology. Gastrointestinal and liver physiology 20070601

• Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20070601

• Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen.

  Endocrinology 20070601

• Effect of wine phenolics on cytokine-induced C-reactive protein expression.

  Journal of thrombosis and haemostasis : JTH 20070601

• The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells.

  The Journal of biological chemistry 20070601

• Golgi complex disassembly caused by light-activated calphostin C involves MAPK and PKA.

  Tissue & cell 20070601

• Mitogen-activated protein kinase phosphatase-1 (MKP-1) preferentially dephosphorylates p42/44MAPK but not p38MAPK in rat pinealocytes.

  Journal of neurochemistry 20070601

• Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan.

  European journal of immunology 20070601

• Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals.

  The FEBS journal 20070601

• Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes.

  Biochimica et biophysica acta 20070601

• Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.

  Hypertension (Dallas, Tex. : 1979) 20070601

• Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.

  Basic & clinical pharmacology & toxicology 20070601

• Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP.

  Experimental biology and medicine (Maywood, N.J.) 20070601

• MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner.

  Endocrine-related cancer 20070601

• Spleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells.

  Archives of pharmacal research 20070601

• MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation.

  Life sciences 20070530

• ERK-dependent and -independent pathways trigger human neural progenitor cell migration.

  Toxicology and applied pharmacology 20070515

• Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells.

  Biochemical and biophysical research communications 20070511

• The inhibitory mechanism of methylmercury on differentiation of human neuroblastoma cells.

  Toxicology 20070505

• Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts.

  Biochemical and biophysical research communications 20070504

• P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells.

  Cellular signalling 20070501

• Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells.

  American journal of physiology. Cell physiology 20070501

• Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR.

  The Biochemical journal 20070501

• Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.

  Journal of leukocyte biology 20070501

• D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism.

  Molecular pharmacology 20070501

• Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells.

  Endocrinology 20070501

• Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway.

  Journal of leukocyte biology 20070501

• Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.

  Journal of cellular physiology 20070501

• Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.

  Journal of dermatological science 20070501

• PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors.

  Molecular human reproduction 20070501

• The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro.

  Laboratory investigation; a journal of technical methods and pathology 20070501

• Abrogation of TGFbeta signaling induces apoptosis through the modulation of MAP kinase pathways in breast cancer cells.

  Experimental cell research 20070501

• Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines.

  Cancer biology & therapy 20070501

• Delay of photoreceptor degeneration in tubby mouse by sulforaphane.

  Journal of neurochemistry 20070501

• Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes.

  Experimental cell research 20070501

• Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation.

  FEBS letters 20070501

• Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways.

  Cornea 20070501

• Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

• ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.

  Molecular cancer therapeutics 20070501

• [CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070501

• p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.

  Experimental & molecular medicine 20070430

• S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.

  Biochemical and biophysical research communications 20070427

• Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.

  The Journal of biological chemistry 20070420

• [High glucose downregulates the expression of podocalyxin protein in glomerular podocytes of mice].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20070418

• Mitogen-activated protein kinase signaling is involved in suramin-induced neurite outgrowth in a neuronal cell line.

  Biochemical and biophysical research communications 20070413

• P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus.

  Biochemical and biophysical research communications 20070406

• Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways.

  Cardiovascular research 20070401

• Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

  Molecular and cellular neurosciences 20070401

• Glucose-based PD solution, but not icodextrin-based PD solution, induces plasminogen activator inhibitor-1 and tissue-type plasminogen activator in human peritoneal mesothelial cells via ERK1/2.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20070401

• Activin A as a critical mediator of capillary formation: interaction with the fibroblast growth factor action.

  Endocrine journal 20070401

• Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.

  Cancer research 20070401

• Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.

  Journal of pharmacological sciences 20070401

• Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle.

  Journal of pharmacological sciences 20070401

• Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway.

  Lasers in surgery and medicine 20070401

• Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells.

  Reproduction (Cambridge, England) 20070401

• Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.

  Biochemical and biophysical research communications 20070323

• 2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.

  European journal of pharmacology 20070322

• A genomic screen for activators of the antioxidant response element.

  Proceedings of the National Academy of Sciences of the United States of America 20070320

• Regulation of glycinergic and GABAergic synaptogenesis by brain-derived neurotrophic factor in developing spinal neurons.

  Neuroscience 20070316

• Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.

  Molecular and cellular endocrinology 20070315

• Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation.

  Carcinogenesis 20070301

• Thyroid hormone changes cardiomyocyte shape and geometry via ERK signaling pathway: potential therapeutic implications in reversing cardiac remodeling?

  Molecular and cellular biochemistry 20070301

• Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup.

  Pain 20070301

• Mitofusin 2 (Mfn2): a key player in insulin-dependent myogenesis in vitro.

  Cell and tissue research 20070301

• Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

  Cellular signalling 20070301

• Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line.

  Journal of cellular biochemistry 20070301

• Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1.

  Journal of leukocyte biology 20070301

• Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2.

  Molecular pharmacology 20070301

• Melanocortin-3 receptor activates MAP kinase via PI3 kinase.

  Regulatory peptides 20070301

• Insulin augments matrix metalloproteinase-9 expression in monocytes.

  Cardiovascular research 20070301

• Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.

  International journal of molecular medicine 20070301

• Genistein prevents thyroid hormone-dependent tail regression of Rana catesbeiana tadpoles by targetting protein kinase C and thyroid hormone receptor alpha.

  Developmental dynamics : an official publication of the American Association of Anatomists 20070301

• Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch.

  Cardiovascular research 20070301

• Berberine stimulates glucose transport through a mechanism distinct from insulin.

  Metabolism: clinical and experimental 20070301

• Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.

  Journal of veterinary science 20070301

• Increased extracellular signal regulated kinases phosphorylation in the adrenal gland in response to chronic ACTH treatment.

  The Journal of endocrinology 20070301

• Green tea polyphenols reduce autoimmune symptoms in a murine model for human Sjogren's syndrome and protect human salivary acinar cells from TNF-alpha-induced cytotoxicity.

  Autoimmunity 20070301

• Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301

• Role of extracellular signal-regulated kinase in glutamate-stimulated apoptosis of rat retinal ganglion cells.

  Current eye research 20070301

• Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione.

  Molecules and cells 20070227

• p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.

  Biochemical and biophysical research communications 20070216

• Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.

  Biochemical and biophysical research communications 20070216

• Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR in canine mastocytoma cells.

  Veterinary immunology and immunopathology 20070215

• Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway.

  Journal of agricultural and food chemistry 20070207

• Insulin-like growth factor-I promotes resistance of bovine preimplantation embryos to heat shock through actions independent of its anti-apoptotic actions requiring PI3K signaling.

  Molecular reproduction and development 20070201

• Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation.

  The Journal of pharmacology and experimental therapeutics 20070201

• Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20070201

• RanGAP-mediated nuclear protein import in vascular smooth muscle cells is augmented by lysophosphatidylcholine.

  Molecular pharmacology 20070201

• 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells.

  Molecular carcinogenesis 20070201

• Thyroid hormone is a MAPK-dependent growth factor for thyroid cancer cells and is anti-apoptotic.

  Steroids 20070201

• The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice.

  Hepatology (Baltimore, Md.) 20070201

• Macrostemonoside A promotes visfatin expression in 3T3-L1 cells.

  Biological & pharmaceutical bulletin 20070201

• Extracellular signal-regulated kinase 1/2 is involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells.

  Journal of periodontology 20070201

• Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium.

  Cancer research 20070201

• [Effect of extracellular-signal regulated kinase 1/2 specific repressor PD98059 on murine lymphocyte proliferation].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070201

• Chemoprotective effect of insulin-like growth factor I against acetaminophen-induced cell death in Chang liver cells via ERK1/2 activation.

  Toxicology 20070125

• The regulation of ATF3 gene expression by mitogen-activated protein kinases.

  The Biochemical journal 20070115

• NO-1886, a lipoprotein lipase activator, attenuates vascular smooth muscle contraction in rat aorta.

  European journal of pharmacology 20070112

• Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK.

  Dental materials : official publication of the Academy of Dental Materials 20070101

• Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells--a possible interaction with psychotropic drugs.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070101

• Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro.

  American journal of physiology. Renal physiology 20070101

• Phosphatidic acid induces the differentiation of human acute promyelocytic leukemic cells into dendritic cell-like.

  Journal of cellular biochemistry 20070101

• Taurine promotes connective tissue growth factor (CTGF) expression in osteoblasts through the ERK signal pathway.

  Amino acids 20070101

• Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts.

  The Biochemical journal 20070101

• Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.

  Endocrinology 20070101

• Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress.

  Biochimie 20070101

• Protein kinase A activation down-regulates, whereas extracellular signal-regulated kinase activation up-regulates sigma-1 receptors in B-104 cells: Implication for neuroplasticity.

  The Journal of pharmacology and experimental therapeutics 20070101

• Truncated midkine correlates with sensitivity to anticancer drugs and malignancy in human tumor cell line.

  Cell biochemistry and function 20070101

• Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection.

  Cardiovascular research 20070101

• Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells.

  Cardiovascular research 20070101

• Upregulation of cyclooxygenases by retinoic acid in rat mesangial cells.

  Pharmacology 20070101

• Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes.

  Neurochemical research 20070101

• PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway.

  International immunopharmacology 20070101

• Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.

  Prostaglandins & other lipid mediators 20070101

• Serum amyloid A induces WISH cell apoptosis.

  Acta pharmacologica Sinica 20070101

• Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells.

  International journal of biological sciences 20070101

• Cell division in the unicellular microalga Dunaliella viridis depends on phosphorylation of extracellular signal-regulated kinases (ERKs).

  Journal of experimental botany 20070101

• Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.

  The FEBS journal 20070101

• Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells.

  British journal of haematology 20070101

• Phosphorylation by extracellular signal-regulated kinase of a multidomain adaptor protein, vinexin, at synapses.

  Journal of neurochemistry 20070101

• Calcium-calmodulin mediates house dust mite-induced ERK activation and IL-8 production in human respiratory epithelial cells.

  Respiration; international review of thoracic diseases 20070101

• Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment.

  Pulmonary pharmacology & therapeutics 20070101

• Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neurons.

  The European journal of neuroscience 20070101

• Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment.

  Critical care (London, England) 20070101

• Involvement of the ERK/MAP kinase signalling pathway in milli-calpain activation and myogenic cell migration.

  The international journal of biochemistry & cell biology 20070101

• Histone deacetylase inhibitors in combinations: will the preclinical promises be kept?

  Cancer journal (Sudbury, Mass.) 20070101

• Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.

  Cancer journal (Sudbury, Mass.) 20070101

• Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway.

  Autophagy 20070101

• Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways.

  The international journal of biochemistry & cell biology 20070101

• Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells.

  Clinical & experimental metastasis 20070101

• Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.

  The international journal of biochemistry & cell biology 20070101

• Signalling mechanisms in the regulation of vacuolar ion release in guard cells.

  The New phytologist 20070101

• Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase.

  Prostaglandins, leukotrienes, and essential fatty acids 20070101

• Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures.

  BMC plant biology 20070101

• Interaction of epidermal growth factor, Ca2+, and matrix metalloproteinase-9 in primary keratinocyte migration.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20070101

• Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex.

  Molecular pain 20070101

• Transcriptome of angiopoietin 1-activated human umbilical vein endothelial cells.

  Endothelium : journal of endothelial cell research 20070101

• gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability.

  Endothelium : journal of endothelial cell research 20070101

• Metabolic and signaling events mediated by cardiotonic steroid ouabain in rat skeletal muscle.

  Cellular and molecular biology (Noisy-le-Grand, France) 20061230

• Acquired TRAIL resistance in human breast cancer cells are caused by the sustained cFLIP(L) and XIAP protein levels and ERK activation.

  Biochemical and biophysical research communications 20061229

• Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.

  Biochemical and biophysical research communications 20061229

• Clusterin enhances proliferation of primary astrocytes through extracellular signal-regulated kinase activation.

  Neuroreport 20061218

• Comparison between basal and apical dendritic spines in estrogen-induced rapid spinogenesis of CA1 principal neurons in the adult hippocampus.

  Biochemical and biophysical research communications 20061215

• Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.

  The Journal of biological chemistry 20061208

• Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine.

  Neuroscience letters 20061206

• Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions.

  Cellular signalling 20061201

• ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts.

  Cellular signalling 20061201

• Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC.

  American journal of physiology. Heart and circulatory physiology 20061201

• Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages.

  Cell and tissue research 20061201

• Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways.

  American journal of physiology. Heart and circulatory physiology 20061201

• Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.

  Molecular pharmacology 20061201

• Bone marrow derived mast cell acquire responsiveness to substance P with Ca(2+) signals and release of leukotriene B(4) via mitogen-activated protein kinase.

  Journal of neuroimmunology 20061201

• Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells.

  Endocrinology 20061201

• Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts.

  The Journal of pharmacology and experimental therapeutics 20061201

• Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis.

  Journal of cellular physiology 20061201

• Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqalpha/MAP kinase signaling pathways.

  Cardiovascular research 20061201

• Evidence for the involvement of proline-directed serine/threonine phosphorylation in sperm capacitation.

  Molecular human reproduction 20061201

• The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells.

  British journal of haematology 20061201

• Phosphorylation of p27(KIP1) in lens epithelial cells after extraction of fiber cells.

  International journal of molecular medicine 20061201

• Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro.

  Reproduction (Cambridge, England) 20061201

• JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation.

  Hepatology (Baltimore, Md.) 20061201

• Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells.

  Cancer research 20061201

• Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.

  The Laryngoscope 20061201

• Angiotensin II does not stimulate proliferation of rat thyroid PC Cl3 cell line.

  The Journal of endocrinology 20061201

• In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20061201

• Effects of (+)-eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells.

  Archives of pharmacal research 20061201

• [Signaling pathways in expression of inducible nitric oxide synthase induced by high mobility group box 1 in rat alveolar macrophages].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20061201

• Pigment epithelium-derived factor promotes neurite outgrowth of retinal cells.

  Hiroshima journal of medical sciences 20061201

• [Influence of signal transduction modulators on the secretory function of T lymphocytes in severely scalded mice and its mechanism].

  Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20061201

• Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).

  Life sciences 20061125

• IL-18 enhances the migration ability of murine melanoma cells through the generation of ROI and the MAPK pathway.

  Immunology letters 20061115

• A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20061115

• DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione.

  Biochemical and biophysical research communications 20061110

• Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells.

  American journal of respiratory cell and molecular biology 20061101

• Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells.

  Stem cells (Dayton, Ohio) 20061101

• HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway.

  Journal of molecular medicine (Berlin, Germany) 20061101

• Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells.

  International journal of radiation oncology, biology, physics 20061101

• p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis.

  Oncology reports 20061101

• Calcineurin and Erk1/2-signaling pathways are involved in the antiapoptotic effect of cyclosporin A on astrocytes exposed to simulated ischemia in vitro.

  Naunyn-Schmiedeberg's archives of pharmacology 20061101

• P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.

  Apoptosis : an international journal on programmed cell death 20061101

• Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence.

  Free radical research 20061101

• PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.

  Cancer research 20061101

• Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

  Cancer cell 20061101

• Ambient pressure upregulates nitric oxide synthase in a phosphorylated-extracellular regulated kinase- and protein kinase C-dependent manner.

  Journal of vascular surgery 20061101

• Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats.

  Archives of pharmacal research 20061101

• Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy.

  Experimental & molecular medicine 20061031

• Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.

  World journal of gastroenterology 20061028

• Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.

  Biochemical and biophysical research communications 20061020

• Ketamine-induced cardiac depression is associated with increase in [Mg2+]i and activation of p38 MAP kinase and ERK 1/2 in guinea pig.

  Biochemical and biophysical research communications 20061020

• H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade.

  World journal of gastroenterology 20061007

• Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells.

  Cellular signalling 20061001

• 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.

  Molecular pharmacology 20061001

• Involvement of nuclear factor I-A1 in the regulation of regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells.

  International journal of molecular medicine 20061001

• ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells.

  Translational research : the journal of laboratory and clinical medicine 20061001

• Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress.

  Diabetes 20061001

• A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives.

  Free radical research 20061001

• Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.

  Gastroenterology 20061001

• [The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20061001

• Role of 15-hydroxyeicosatetraenoic acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells.

  Canadian journal of physiology and pharmacology 20061001

• The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.

  Biochemical pharmacology 20060928

• Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation.

  Brain research 20060927

• Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation.

  Brain research 20060927

• Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells.

  Toxicology 20060921

• Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.

  Proceedings of the National Academy of Sciences of the United States of America 20060919

• Inhibition of the janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication.

  Cancer research 20060915

• Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes.

  Cancer research 20060915

• Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

• Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20060908

• Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.

  Biochemical and biophysical research communications 20060908

• p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.

  Life sciences 20060905

• TGF-beta regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2.

  Cellular signalling 20060901

• Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.

  The Journal of surgical research 20060901

• Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.

  International journal of cancer 20060901

• Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.

  Journal of cellular biochemistry 20060901

• CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection.

  Virology 20060901

• Differential regulation of melanosomal proteins after hinokitiol treatment.

  Journal of dermatological science 20060901

• Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.

  The Journal of clinical endocrinology and metabolism 20060901

• HU0622: a small molecule promoting GAP-43 activation and neurotrophic effects.

  Neuropharmacology 20060901

• p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis.

  Biochemical and biophysical research communications 20060901

• Kinase-dependent, retinoic acid receptor-independent up-regulation of cyclooxygenase-2 by all-trans retinoic acid in human mesangial cells.

  British journal of pharmacology 20060901

• Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.

  American journal of physiology. Heart and circulatory physiology 20060901

• Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.

  Biochimica et biophysica acta 20060901

• Inactivation of MAPK in mature oocytes triggers progression into mitosis via a Ca2+ -dependent pathway but without completion of S phase.

  Journal of cell science 20060901

• JWA is required for the antiproliferative and pro-apoptotic effects of all-trans retinoic acid in Hela cells.

  Clinical and experimental pharmacology & physiology 20060901

• Mitogen-activated protein kinase (MAPK) signalling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae.

  Cellular microbiology 20060901

• Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

  Arthritis and rheumatism 20060901

• Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901

• Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.

  The Journal of endocrinology 20060901

• Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells.

  Biochemical and biophysical research communications 20060825

• Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes.

  Life sciences 20060815

• Ligustilide inhibits vascular smooth muscle cells proliferation.

  European journal of pharmacology 20060807

• Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.

  The Journal of pharmacology and experimental therapeutics 20060801

• Involvement of ERK1/2 and p38 in Mg2+ accumulation in liver cells.

  Molecular and cellular biochemistry 20060801

• Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.

  International journal of molecular medicine 20060801

• German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells.

  Allergy 20060801

• On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.

  Pancreas 20060801

• ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival.

  Diabetes 20060801

• Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.

  Prostaglandins, leukotrienes, and essential fatty acids 20060801

• The regulatory mechanism by which interleukin-6 stimulates GH-gene expression in rat GH3 cells.

  The Journal of endocrinology 20060801

• Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.

  Molecular cancer therapeutics 20060801

• [Protective effect of protein kinase C and mitogen-activated protein kinases and its mechanism in liver ischemic preconditioning].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060801

• Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.

  Free radical research 20060801

• Alteration of an essential NK cell signaling pathway by low doses of tributyltin in human natural killer cells.

  Toxicology 20060725

• Effects of genistein on angiotensin-converting enzyme in rats.

  Life sciences 20060724

• Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.

  Experimental cell research 20060715

• Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade.

  Free radical biology & medicine 20060715

• Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells.

  Biochemical and biophysical research communications 20060714

• Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene.

  International journal of cancer 20060701

• A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation.

  Blood 20060701

• Gonadotropin regulation of testosterone production by primary cultured theca and granulosa cells of Atlantic croaker: II. Involvement of a mitogen-activated protein kinase pathway.

  General and comparative endocrinology 20060701

• Involvement of mitogen-activated protein kinase in 2-hydroxyestradiol-17beta-induced oocyte maturation in the catfish Heteropneustes fossilis and a note on possible interaction with protein phosphatases.

  General and comparative endocrinology 20060701

• Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.

  Gene therapy 20060701

• Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes.

  Molecular pharmacology 20060701

• c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20060701

• Norepinephrine-induced changes in gene expression of phospholipase C in cardiomyocytes.

  Journal of molecular and cellular cardiology 20060701

• Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways.

  Experimental dermatology 20060701

• Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells.

  International journal of molecular medicine 20060701

• Endothelin-1 activates Homer 1alpha expression via mitogen-activated protein kinase in cardiac myocytes.

  International journal of molecular medicine 20060701

• Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways.

  Clinical and experimental immunology 20060701

• Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation.

  Molecular and cellular biology 20060701

• Hormonal regulation of cytochrome P450 aromatase mRNA stability in non-luteinizing bovine granulosa cells in vitro.

  The Journal of endocrinology 20060701

• Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model.

  Molecular cancer therapeutics 20060701

• Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.

  The Journal of biological chemistry 20060630

• Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A.

  Biochemical and biophysical research communications 20060623

• p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis.

  International journal of cancer 20060615

• Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages.

  Atherosclerosis 20060601

• Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells.

  Archives of toxicology 20060601

• Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway.

  American journal of physiology. Heart and circulatory physiology 20060601

• Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060601

• Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathway.

  American journal of physiology. Endocrinology and metabolism 20060601

• Src oncogene activates MMP-2 expression via the ERK/Sp1 pathway.

  Journal of cellular physiology 20060601

• Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways.

  Biology of reproduction 20060601

• Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling.

  The Journal of pharmacology and experimental therapeutics 20060601

• The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells.

  Leukemia 20060601

• Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells.

  Toxicology 20060601

• Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells.

  Molecular cancer research : MCR 20060601

• Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.

  Microbes and infection 20060601

• Dracorhodin perchlorate induces apoptosis in HL-60 cells.

  Journal of Asian natural products research 20060601

• The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells.

  Biochemical pharmacology 20060528

• Amyloid precursor protein is involved in staurosporine induced glial differentiation of neural progenitor cells.

  Biochemical and biophysical research communications 20060526

• Effects of different magnitudes of mechanical strain on Osteoblasts in vitro.

  Biochemical and biophysical research communications 20060526

• Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

  Oncogene 20060518

• [Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].

  Zhonghua yi xue za zhi 20060516

• Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.

  Regulatory peptides 20060515

• N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.

  Oncogene 20060504

• Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line.

  Life sciences 20060501

• Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.

  Molecular endocrinology (Baltimore, Md.) 20060501

• Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20060501

• Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells.

  Neuroscience letters 20060501

• The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.

  Journal of cellular physiology 20060501

• Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway.

  Experimental cell research 20060501

• Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.

  Endocrinology 20060501

• Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells.

  Molecular pharmacology 20060501

• Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.

  Journal of cellular physiology 20060501

• Mechanisms underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in vitro.

  Molecular pharmacology 20060501

• MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.

  Cardiovascular research 20060501

• Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20060501

• Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries.

  Kidney international 20060501

• Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.

  Free radical biology & medicine 20060501

• Insulin increases gelatinase activity in rat glomerular mesangial cells via ERK- and PI-3 kinase-dependent signalling.

  Diabetes, obesity & metabolism 20060501

• Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facility.

  Investigative ophthalmology & visual science 20060501

• [Effects of ERK deactivation on functions of rat cultured hepatic stellate cells stimulated by acetaldehyde].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060501

• betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin.

  Experimental & molecular medicine 20060430

• Nerve growth factor activates brain-derived neurotrophic factor promoter IV via extracellular signal-regulated protein kinase 1/2 in PC12 cells.

  Molecules and cells 20060430

• Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway.

  Biochemical and biophysical research communications 20060428

• Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cells.

  Toxicology and applied pharmacology 20060415

• Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels.

  Journal of cellular biochemistry 20060415

• The kv4.2 potassium channel subunit is required for pain plasticity.

  Neuron 20060406

• The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for phosphatidylinositol 3-kinase, extracellular signal-regulated kinase and Mcl-1.

  Cellular signalling 20060401

• JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells.

  Experimental eye research 20060401

• The role of progestin receptors and the mitogen-activated protein kinase pathway in delta opioid receptor facilitation of female reproductive behaviors.

  Hormones and behavior 20060401

• Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells.

  American journal of physiology. Cell physiology 20060401

• Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway.

  Endocrinology 20060401

• Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells.

  Endocrinology 20060401

• Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.

  Vascular pharmacology 20060401

• Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.

  Arteriosclerosis, thrombosis, and vascular biology 20060401

• Participation of estrogen receptors in the enhancement of osteoblast differentiation by TAK-778.

  Molecular and cellular biochemistry 20060401

• Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.

  Naunyn-Schmiedeberg's archives of pharmacology 20060401

• Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.

  Pigment cell research 20060401

• Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts.

  Kidney international 20060401

• Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.

  Acta pharmacologica Sinica 20060401

• Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesis.

  Cell proliferation 20060401

• Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling.

  Anti-cancer drugs 20060401

• Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20060401

• Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.

  Thyroid : official journal of the American Thyroid Association 20060401

• Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.

  IUBMB life 20060401

• EGFR signaling pathway negatively regulates PSA expression and secretion via the PI3K-Akt pathway in LNCaP prostate cancer cells.

  Biochemical and biophysical research communications 20060331

• Effects of betaine on ethanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes: involvement of p42/44 MAPK activation.

  World journal of gastroenterology 20060321

• Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060301

• Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells.

  Cell death and differentiation 20060301

• The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.

  Molecular endocrinology (Baltimore, Md.) 20060301

• Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway.

  American journal of physiology. Cell physiology 20060301

• Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway.

  Molecular endocrinology (Baltimore, Md.) 20060301

• Mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel contraction.

  Experimental eye research 20060301

• Activity-dependent potentiation of large dense-core vesicle release modulated by mitogen-activated protein kinase/extracellularly regulated kinase signaling.

  Endocrinology 20060301

• Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.

  The Journal of pharmacology and experimental therapeutics 20060301

• Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway.

  Molecular pharmacology 20060301

• Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins.

  Molecular pharmacology 20060301

• COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.

  Lung cancer (Amsterdam, Netherlands) 20060301

• Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.

  British journal of pharmacology 20060301

• Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes.

  Prostaglandins, leukotrienes, and essential fatty acids 20060301

• Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.

  Investigative ophthalmology & visual science 20060301

• Calcium signaling stimulates translation of HIF-alpha during hypoxia.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Salviae miltiorrhizae radix increases dopamine release of rat and pheochromocytoma PC12 cells.

  Phytotherapy research : PTR 20060301

• Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

  The Journal of endocrinology 20060301

• Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats.

  The Journal of endocrinology 20060301

• Exendin-4 induction of cyclin D1 expression in INS-1 beta-cells: involvement of cAMP-responsive element.

  The Journal of endocrinology 20060301

• Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.

  Molecular cancer research : MCR 20060301

• Serum- and glucocorticoid-inducible kinase (SGK) is a target of the MAPK/ERK signaling pathway that mediates memory formation in rats.

  The European journal of neuroscience 20060301

• Effect of endothelin-1 on lipolysis in rat adipocytes.

  Obesity (Silver Spring, Md.) 20060301

• Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines.

  European journal of pharmacology 20060227

• Heme oxygenase 1 mediates anti-inflammatory effects of 2',4',6'-tris(methoxymethoxy) chalcone.

  European journal of pharmacology 20060217

• Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.

  Cardiovascular research 20060215

• Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells.

  Experimental cell research 20060215

• Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.

  Cardiovascular research 20060215

• Modulatory effect of interleukin-1beta on rat isolated basilar artery contraction.

  European journal of pharmacology 20060215

• Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes.

  Journal of cell science 20060215

• [Regulation of heat shock protein 27/activating transcription factor-5 complex and its implication in podocyte apoptosis induced by high glucose].

  Zhonghua yi xue za zhi 20060214

• Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages.

  Molecular immunology 20060201

• Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO.

  Cell death and differentiation 20060201

• Fibroblast growth factor-23 increases mouse PGE2 production in vivo and in vitro.

  American journal of physiology. Renal physiology 20060201

• Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

  Journal of cellular biochemistry 20060201

• 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.

  American journal of respiratory cell and molecular biology 20060201

• Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.

  Molecular pharmacology 20060201

• Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure.

  Endocrinology 20060201

• Pea3 expression is regulated by FGF signaling in developing retina.

  Developmental dynamics : an official publication of the American Association of Anatomists 20060201

• Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.

  Journal of leukocyte biology 20060201

• Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation.

  Journal of neuroscience research 20060201

• The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.

  International immunopharmacology 20060201

• Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages.

  The Journal of nutrition 20060201

• Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060201

• Retinoic acid induces expression of SLP-76: expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells.

  European journal of cell biology 20060201

• Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny.

  Cancer research 20060201

• Mitogen-activated protein kinase is involved in the progesterone-mediated induction of baboon glycodelin.

  Endocrine 20060201

• Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.

  FEBS letters 20060123

• Signaling transduction pathways involved in basophil adhesion and histamine release.

  Chinese medical journal 20060120

• Low concentrations of nitric oxide (NO) induced cell death in PC12 cells through activation of p38 mitogen-activated protein kinase (p38 MAPK) but not via extracellular signal-regulated kinases (ERK1/2) or c-Jun N-terminal protein kinase (JNK).

  Neuroscience letters 20060116

• Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A.

  Toxicology 20060116

• Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line.

  Experimental cell research 20060115

• Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways.

  Journal of immunology (Baltimore, Md. : 1950) 20060115

• Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.

  The Journal of biological chemistry 20060113

• MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells.

  Journal of cellular physiology 20060101

• BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes.

  Journal of cellular physiology 20060101

• Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.

  Drug metabolism and disposition: the biological fate of chemicals 20060101

• Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb.

  Endocrinology 20060101

• The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.

  The Journal of pharmacology and experimental therapeutics 20060101

• Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways.

  Journal of neurochemistry 20060101

• Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

  Journal of biomedical science 20060101

• Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells.

  International journal of molecular medicine 20060101

• Differential regulation of interleukin-12 and tumour necrosis factor-alpha by phosphatidylinositol 3-kinase and ERK 1/2 pathways during Mycobacterium tuberculosis infection.

  Clinical and experimental immunology 20060101

• Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells.

  The Journal of endocrinology 20060101

• Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin.

  The Journal of endocrinology 20060101

• The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo.

  The American journal of pathology 20060101

• Salviae Miltiorrhizae BGE Radix increases rat striatal K(+)-stimulated dopamine release and activates the dopamine release with protection against hydrogen peroxide-induced injury in rat pheochromocytoma PC12 cells.

  Neurochemical research 20060101

• The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.

  Neoplasia (New York, N.Y.) 20060101

• High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-beta1-induced alpha smooth muscle actin expression in human fetal lung fibroblasts in vitro.

  Lung 20060101

• The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction.

  Antioxidants & redox signaling 20060101

• Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.

  The international journal of biochemistry & cell biology 20060101

• Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis.

  Methods in enzymology 20060101

• [Study of drugs against neoplastic metastasis].

  Magyar onkologia 20060101

• Asbestos-induced activation of cell signaling pathways in human bronchial epithelial cells.

  Experimental lung research 20060101

• Expression and modulation of the intermediate- conductance Ca2+-activated K+ channel in glioblastoma GL-15 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Inhibition of CD95-mediated apoptosis through beta 1 integrin in the HSG epithelial cell line.

  Cell communication & adhesion 20060101

• Mechanoregulation of monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.

  Antioxidants & redox signaling 20060101

• Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.

  Antioxidants & redox signaling 20060101

• Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.

  Immunopharmacology and immunotoxicology 20060101

• Regulation of ROMK (Kir 1.1) channel expression in kidney thick ascending limb by hypertonicity: role of TonEBP and MAPK pathways.

  Nephron. Physiology 20060101

• Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells.

  Journal of applied toxicology : JAT 20060101

• ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.

  Journal of molecular neuroscience : MN 20060101

• Inhibition of the Na+-H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.

  Reproductive biology and endocrinology : RB&E 20060101

• Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

• LIF upregulates expression of NK-1R in NHBE cells.

  Mediators of inflammation 20060101

• Cytokine interactions in mesenchymal stem cells from cord blood.

  Cytokine 20051221

• 5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.

  FEBS letters 20051219

• Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes.

  Biochemical pharmacology 20051205

• FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression.

  Biochemical and biophysical research communications 20051202

• Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway.

  Cellular signalling 20051201

• Leptin induces rat glomerular mesangial cell hypertrophy, but does not regulate hyperplasia or apoptosis.

  International journal of obesity (2005) 20051201

• Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin.

  Journal of cellular biochemistry 20051201

• Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling.

  Journal of neurochemistry 20051201

• Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201

• The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines.

  Head & neck 20051201

• Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats.

  Journal of hypertension 20051201

• Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.

  Diabetologia 20051201

• Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblastsdagger.

  Fundamental & clinical pharmacology 20051201

• Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.

  Cancer research 20051201

• Effect of biologic mediators on ciprofloxacin accumulation by gingival fibroblasts.

  Journal of periodontology 20051201

• Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201

• Induction of neurite outgrowth by (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol from PC12 cells.

  Archives of pharmacal research 20051201

• Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways.

  Thrombosis and haemostasis 20051201

• Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway.

  Obesity research 20051201

• Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium.

  Environmental toxicology and chemistry 20051201

• Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.

  Clinical and experimental pharmacology & physiology 20051201

• [Oridonin induced U937 cell apoptosis through ERK pathway].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201

• Phosphorylation of the Brn-3a transcription factor is modulated during differentiation and regulates its functional activity.

  Brain research. Molecular brain research 20051118

• Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20051116

• Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein.

  The Biochemical journal 20051115

• Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.

  Journal of neuroscience research 20051115

• Glucose represses connexin36 in insulin-secreting cells.

  Journal of cell science 20051115

• The role of p38 MAP kinase and c-Jun N-terminal protein kinase signaling in the differentiation and apoptosis of immortalized neural stem cells.

  Mutation research 20051111

• Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.

  The Journal of biological chemistry 20051111

• Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.

  Biochemical and biophysical research communications 20051104

• PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.

  Biochemical and biophysical research communications 20051104

• 2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.

  Biology of reproduction 20051101

• 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells.

  Molecular pharmacology 20051101

• Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.

  The Journal of pharmacology and experimental therapeutics 20051101

• Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways.

  Journal of neuroimmunology 20051101

• Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.

  Journal of lipid research 20051101

• Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients.

  Allergy 20051101

• Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells.

  International journal of oncology 20051101

• Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.

  Digestive diseases and sciences 20051101

• ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells.

  Molecular and cellular biochemistry 20051101

• Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.

  Molecular and cellular biochemistry 20051101

• Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells.

  Neurotoxicity research 20051101

• Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways.

  Cellular immunology 20051101

• [Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051101

• [Role of MAPK in the migration of human coronary artery smooth muscle cell into three-dimensional fibrin gel].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101

• ERK1/2 signaling pathway is involved in 15-hydroxyeicosatetraenoic acid-induced hypoxic pulmonary vasoconstriction.

  Sheng li xue bao : [Acta physiologica Sinica] 20051025

• Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.

  Mediators of inflammation 20051024

• Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

  Neuron 20051020

• PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism.

  Journal of cellular biochemistry 20051015

• Role of cytosolic phospholipase A2 in the enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: comparison with vasopressin-enhanced responses.

  Biochemical pharmacology 20051015

• TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

  Journal of cell science 20051015

• Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

  European journal of pharmacology 20051003

• Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.

  Carcinogenesis 20051001

• Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms.

  The international journal of biochemistry & cell biology 20051001

• Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20051001

• Type IV collagen induces down-regulation of steroidogenic response to gonadotropins in adult rat Leydig cells involving mitogen-activated protein kinase.

  Molecular reproduction and development 20051001

• Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.

  Cellular signalling 20051001

• Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK.

  Experimental cell research 20051001

• HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.

  Journal of leukocyte biology 20051001

• Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation.

  Hypertension (Dallas, Tex. : 1979) 20051001

• Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823.

  International journal of molecular medicine 20051001

• JTT-705 blocks cell proliferation and angiogenesis through p38 kinase/p27(kip1) and Ras/p21(waf1) pathways.

  Atherosclerosis 20051001

• Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase.

  Neuropeptides 20051001

• Distribution of extracellular signal-regulated protein kinases 1 and 2 in the rat adrenal and their activation by angiotensin II.

  The Journal of endocrinology 20051001

• Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells.

  Molecular cancer therapeutics 20051001

• Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells.

  Biochimica et biophysica acta 20050930

• LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways.

  Biochemical and biophysical research communications 20050930

• beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

  The Journal of biological chemistry 20050916

• Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory.

  Neuron 20050915

• Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids.

  The Journal of biological chemistry 20050909

• Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.

  European journal of pharmacology 20050905

• Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.

  Cardiovascular research 20050901

• Growth factors change nuclear distribution of estrogen receptor-alpha via mitogen-activated protein kinase or phosphatidylinositol 3-kinase cascade in a human breast cancer cell line.

  Endocrinology 20050901

• Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol.

  Toxicological sciences : an official journal of the Society of Toxicology 20050901

• S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microglia.

  Journal of neuroscience research 20050901

• Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

• Adenosine triggers preconditioning through MEK/ERK1/2 signalling pathway during hypoxia/reoxygenation in neonatal rat cardiomyocytes.

  Journal of molecular and cellular cardiology 20050901

• Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells.

  Journal of toxicology and environmental health. Part A 20050901

• Mechanism of telomerase repression during terminal differentiation of normal epithelial cells and squamous carcinoma lines.

  International journal of oncology 20050901

• Anthrax lethal toxin paralyzes neutrophil actin-based motility.

  The Journal of infectious diseases 20050901

• Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

  Pain 20050901

• Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.

  The Journal of pharmacy and pharmacology 20050901

• Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.

  European journal of immunology 20050901

• G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.

  Journal of immunology (Baltimore, Md. : 1950) 20050901

• Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.

  The American journal of pathology 20050901

• Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils.

  Shock (Augusta, Ga.) 20050901

• Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.

  Cancer research 20050901

• [Inhibition of the in vitro interaction between hypoxia inducible factor 1alpha and p300 by mitogen-activated protein kinase phosphatase 1].

  Zhonghua yi xue za zhi 20050831

• cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK.

  Neuroreport 20050822

• Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis.

  Journal of cellular biochemistry 20050815

• Involvement of extracellular regulated kinase and p38 kinase in hippocampal seizure tolerance.

  Journal of neuroscience research 20050815

• Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase.

  Journal of neuroscience research 20050815

• Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050815

• Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-kappaB, ERK, and p38 mitogen-activated protein kinases.

  Biochemical and biophysical research communications 20050812

• NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation.

  Carcinogenesis 20050801

• p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development.

  Biology of the cell 20050801

• EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.

  Molecular reproduction and development 20050801

• Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways.

  Journal of leukocyte biology 20050801

• Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336).

  Molecular pharmacology 20050801

• Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent.

  Leukemia research 20050801

• Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif.

  Biochimica et biophysica acta 20050801

• The inhibitory effects of sevoflurane on angiotensin II- induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle.

  Anesthesia and analgesia 20050801

• Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

  Nature cell biology 20050801

• Angiopoietin 1 is mitogenic for cultured endothelial cells.

  Cancer research 20050801

• Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.

  Journal of pharmacological sciences 20050801

• Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.

  Journal of pharmacological sciences 20050801

• Role of leptin in modulation of Porphyromonas gingivalis lipopolysaccharide-induced up-regulation of endothelin-1 in salivary gland acinar cells.

  IUBMB life 20050801

• Direct phosphorylation of proliferative and survival pathway proteins by RET.

  Surgery 20050801

• Signaling pathway in nerve growth factor induced histamine release from rat mast cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050801

• Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.

  Archives of pharmacal research 20050801

• Histamine induces tissue factor expression: implications for acute coronary syndromes.

  Circulation 20050719

• PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone.

  FEBS letters 20050718

• ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta.

  The Journal of physiology 20050715

• Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes.

  The Journal of biological chemistry 20050715

• Characterization of cAMP-dependent proteolysis of GATA-6.

  Biochemical and biophysical research communications 20050715

• PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.

  Life sciences 20050715

• Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

• Leptin rapidly activates PPARs in C2C12 muscle cells.

  Biochemical and biophysical research communications 20050708

• Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway.

  Life sciences 20050708

• Reactive oxygen species and protein kinases modulate the level of phospho-MEK-like proteins during human sperm capacitation.

  Biology of reproduction 20050701

• PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis.

  Molecular reproduction and development 20050701

• Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells.

  Endocrinology 20050701

• Morphogenetic plasticity of adult human pancreatic islets of Langerhans.

  Cell death and differentiation 20050701

• Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils.

  Journal of leukocyte biology 20050701

• Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide.

  The Journal of biological chemistry 20050701

• Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents.

  Biochemical pharmacology 20050701

• Polypeptide from Chlamys farreri inhibits murine thymocytes apoptosis and modulates UVB induced signaling pathway activation.

  Life sciences 20050701

• Phosphorylation of p42/44 MAP kinase is required for rF1-induced activation of murine peritoneal macrophages.

  Molecular immunology 20050701

• [Exploration of ganglioside GM1 as an activation marker on T cells].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20050701

• A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death.

  Cancer research 20050701

• Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

  The Journal of rheumatology 20050701

• Stimulation of catecholamine biosynthesis via the PKC pathway by prolactin-releasing peptide in PC12 rat pheochromocytoma cells.

  The Journal of endocrinology 20050701

• Signal pathway of cytokines produced by reactive oxygen species generated from phorbol myristate acetate-stimulated HMC-1 cells.

  Scandinavian journal of immunology 20050701

• H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway.

  European journal of cell biology 20050701

• PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes.

  Molecular and cellular biochemistry 20050701

• Angiotensin IV enhances phosphorylation of 4EBP1 by multiple signaling events in lung endothelial cells.

  Molecular and cellular biochemistry 20050701

• Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.

  The Journal of biological chemistry 20050617

• Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.

  The Journal of biological chemistry 20050617

• Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages.

  Biochemical pharmacology 20050615

• alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.

  Archives of biochemistry and biophysics 20050615

• Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.

  Toxicology and applied pharmacology 20050615

• Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.

  The Journal of biological chemistry 20050610

• Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.

  The Journal of biological chemistry 20050603

• Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC.

  American journal of physiology. Heart and circulatory physiology 20050601

• Metabolites of benzene are potent inhibitors of gap-junction intercellular communication.

  Archives of toxicology 20050601

• Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells.

  The Journal of reproduction and development 20050601

• Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.

  Carcinogenesis 20050601

• Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.

  British journal of pharmacology 20050601

• Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling.

  British journal of pharmacology 20050601

• Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells.

  Histochemistry and cell biology 20050601

• Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells.

  Bone 20050601

• Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages.

  Immunology and cell biology 20050601

• Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells.

  Journal of neuroscience research 20050601

• Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.

  Biochemical pharmacology 20050601

• Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.

  Cellular and molecular life sciences : CMLS 20050601

• Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).

  European journal of pharmacology 20050601

• Direct activation of telomerase by GH via phosphatidylinositol 3'-kinase.

  The Journal of endocrinology 20050601

• Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.

  The Journal of endocrinology 20050601

• Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells.

  Cancer research 20050601

• Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050601

• PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.

  Experimental oncology 20050601

• Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens.

  Current eye research 20050601

• Position of STAT-1 alpha in cycloheximide-dependent apoptosis triggered by TNF-alpha in human colorectal COLO 205 cancer cell line; role of polyphenolic compounds.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050601

• Dissimilar effects of LY 294002 and PD 098059 in IGF-I-mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050601

• Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.

  Nagoya journal of medical science 20050601

• delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.

  Brain research. Molecular brain research 20050520

• Transcriptional profiling of gamma delta T cells identifies a role for vitamin D in the immunoregulation of the V gamma 9V delta 2 response to phosphate-containing ligands.

  Journal of immunology (Baltimore, Md. : 1950) 20050515

• Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel.

  Cancer research 20050515

• Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.

  European journal of pharmacology 20050509

• Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR.

  Oncogene 20050505

• Benzoquinone activates the ERK/MAPK signaling pathway via ROS production in HL-60 cells.

  Toxicology 20050505

• A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption.

  American journal of physiology. Cell physiology 20050501

• Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501

• Effects of MAP kinase pathway and other factors on meiosis of Urechis unicinctus eggs.

  Molecular reproduction and development 20050501

• Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.

  The Journal of biological chemistry 20050501

• Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines.

  International immunopharmacology 20050501

• Reduction of concanavalin A-induced expression of interferon-gamma by bovine lactoferrin in feline peripheral blood mononuclear cells.

  Veterinary immunology and immunopathology 20050501

• IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.

  Journal of immunology (Baltimore, Md. : 1950) 20050501

• Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro.

  Journal of neurochemistry 20050501

• Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis.

  Cancer research 20050501

• Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

  Gastroenterology 20050501

• [Effects of MAPK antagonist on TPO stimulated UT2 cells proliferation and differentiation].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050501

• Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.

  The Journal of steroid biochemistry and molecular biology 20050501

• Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.

  Life sciences 20050429

• ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite.

  Biochemical and biophysical research communications 20050422

• Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis.

  Chinese medical journal 20050420

• Growth-promoting effect of platelet-derived growth factor on rat cardiac myocytes.

  Regulatory peptides 20050415

• Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway.

  Journal of cellular biochemistry 20050415

• Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation.

  Biochimica et biophysica acta 20050415

• Nuclear phospholipase C-beta1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells.

  Biochimica et biophysica acta 20050415

• Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.

  Biochimica et biophysica acta 20050415

• MAPKs mediate the activation of cytosolic phospholipase A2 by amyloid beta(25-35) peptide in bovine retina pericytes.

  Biochimica et biophysica acta 20050415

• Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion.

  The Journal of biological chemistry 20050408

• Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

  The Journal of biological chemistry 20050408

• Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation.

  Life sciences 20050408

• Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression.

  Circulation 20050405

• Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway.

  American journal of physiology. Heart and circulatory physiology 20050401

• N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase, mitogen- and stress-activated kinase, and ribosomal s6 kinase phosphorylation in cortical neurons.

  Molecular pharmacology 20050401

• Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways.

  American journal of respiratory cell and molecular biology 20050401

• Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells.

  American journal of respiratory cell and molecular biology 20050401

• A new hypertrophic mechanism of serotonin in cardiac myocytes: receptor-independent ROS generation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401

• Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.

  Biochemical and biophysical research communications 20050401

• Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.

  Biochemical and biophysical research communications 20050401

• Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.

  Biochemical and biophysical research communications 20050401

• Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.

  Biochemical and biophysical research communications 20050401

• Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat.

  Journal of the American Society of Nephrology : JASN 20050401

• Multiple pathways of apolipoprotein E signaling in primary neurons.

  Journal of neurochemistry 20050401

• Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

  Journal of neurochemistry 20050401

• Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.

  Diabetes 20050401

• Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression.

  Journal of molecular and cellular cardiology 20050401

• Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties.

  Molecular cancer therapeutics 20050401

• Elevated expression of NF-kappaB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 and SB203580.

  Cell biology international 20050401

• Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.

  Regulatory peptides 20050330

• Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells.

  Regulatory peptides 20050330

• Beta-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330

• Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.

  European journal of pharmacology 20050328

• ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.

  FEBS letters 20050328

• Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling.

  The Journal of biological chemistry 20050325

• Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.

  European journal of pharmacology 20050314

• Inhibition of Src-like kinases reveals Akt-dependent and -independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival.

  The Journal of biological chemistry 20050311

• Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis.

  The Journal of biological chemistry 20050304

• Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

  The Journal of biological chemistry 20050304

• Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.

  Circulation research 20050304

• Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways.

  Circulation research 20050304

• Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.

  Endocrinology 20050301

• Induction of nitric oxide production by the cytostatic macrolide apicularen A [2,4-heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and possible role of nitric oxide in apicularen A-induced apoptosis in RAW 264.7 cells.

  The Journal of pharmacology and experimental therapeutics 20050301

• Transfected beta3- but not beta2-adrenergic receptors regulate cystic fibrosis transmembrane conductance regulator activity via a new pathway involving the mitogen-activated protein kinases extracellular signal-regulated kinases.

  Molecular pharmacology 20050301

• Fer kinase sustains the activation level of ERK1/2 and increases the production of VEGF in hypoxic cells.

  Cellular signalling 20050301

• In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling.

  American journal of physiology. Lung cellular and molecular physiology 20050301

• Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.

  Molecular pharmacology 20050301

• Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism.

  American journal of respiratory cell and molecular biology 20050301

• PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling.

  International journal of oncology 20050301

• Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells.

  The Journal of veterinary medical science 20050301

• SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050301

• Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells.

  Molecular and cellular biochemistry 20050301

• [Study of IL-8 overexpression in A549 cells induced by crocidolite fibers].

  Wei sheng yan jiu = Journal of hygiene research 20050301

• Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells.

  Cell biology and toxicology 20050301

• Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein.

  Molecular and cellular endocrinology 20050227

• The Src/PLC/PKC/MEK/ERK signaling pathway is involved in aortic smooth muscle cell proliferation induced by glycated LDL.

  Molecules and cells 20050227

• A novel pathway for presynaptic mitogen-activated kinase activation via AMPA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

• Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

  American journal of respiratory and critical care medicine 20050215

• La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells.

  Journal of cellular biochemistry 20050215

• ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation.

  The Journal of biological chemistry 20050211

• Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.

  Circulation research 20050204

• CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase.

  Cellular signalling 20050201

• Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway.

  Cellular signalling 20050201

• Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome.

  Molecular endocrinology (Baltimore, Md.) 20050201

• alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway.

  Endocrinology 20050201

• MEK inhibitors block AICAR-induced maturation in mouse oocytes by a MAPK-independent mechanism.

  Molecular reproduction and development 20050201

• Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling.

  Experimental cell research 20050201

• Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events.

  The Journal of clinical endocrinology and metabolism 20050201

• c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• Differential effect of insulin and elevated glucose level on adenosine transport in rat B lymphocytes.

  International immunology 20050201

• ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos.

  Development (Cambridge, England) 20050201

• Insulin enhanced thrombin-activable fibrinolysis inhibitor expression through PI3 kinase/Akt pathway.

  International journal of molecular medicine 20050201

• PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung.

  Tissue & cell 20050201

• Antigen binding of human IgG Fabs mediate ERK-associated proliferation of human breast cancer cells.

  DNA and cell biology 20050201

• Methyl mercury influences growth-related signaling in MCF-7 breast cancer cells.

  Environmental toxicology 20050201

• Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation.

  The European journal of neuroscience 20050201

• IL-1-induced receptor activator of NF-kappa B ligand in human periodontal ligament cells involves ERK-dependent PGE2 production.

  Bone 20050201

• [The impact of different provocations on ERK translocation and c-fos expression in neonatal cultured cardiomyocytes].

  Zhonghua nei ke za zhi 20050201

• Sulindac sulfide-induced apoptosis in sinonasal cancer cells.

  Acta oto-laryngologica 20050201

• Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells.

  Experimental cell research 20050115

• Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.

  Toxicology 20050115

• Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha.

  Toxicology 20050115

• Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

  Chemico-biological interactions 20050115

• Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112

• [ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion].

  Zhonghua yi xue za zhi 20050112

• PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway.

  FEBS letters 20050103

• Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways.

  Medical microbiology and immunology 20050101

• Hydrogen peroxide-induced extracellular signal-regulated kinase activation in cultured feline ileal smooth muscle cells.

  The Journal of pharmacology and experimental therapeutics 20050101

• Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy.

  American journal of physiology. Heart and circulatory physiology 20050101

• Cocaine induces apoptosis in fetal rat myocardial cells through the p38 mitogen-activated protein kinase and mitochondrial/cytochrome c pathways.

  The Journal of pharmacology and experimental therapeutics 20050101

• Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction.

  American journal of physiology. Cell physiology 20050101

• Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor.

  Journal of immunology (Baltimore, Md. : 1950) 20050101

• Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.

  Diabetes 20050101

• Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.

  Arthritis research & therapy 20050101

• Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.

  Molecular cancer therapeutics 20050101

• Interleukin-1beta-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK.

  Nephron. Experimental nephrology 20050101

• Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.

  Journal of vascular surgery 20050101

• MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden.

  International journal of immunopathology and pharmacology 20050101

• Inhibition of different intracellular signal cascades in human pancreatic cancer cells.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20050101

• Acetylation of nuclear hormone receptor superfamily members: thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism.

  Steroids 20050101

• Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.

  Neuroscience 20050101

• Cytoskeleton reorganization mediates alpha6beta1 integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells.

  Reproductive biology and endocrinology : RB&E 20050101

• Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase.

  Neuroscience 20050101

• The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2.

  International archives of allergy and immunology 20050101

• Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells.

  Journal of applied toxicology : JAT 20050101

• The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells.

  Journal of applied toxicology : JAT 20050101

• Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.

  Journal of molecular neuroscience : MN 20050101

• Hepatocyte growth factor delivered by ultrasound-mediated destruction of microbubbles induces proliferation of cardiomyocytes and amelioration of left ventricular contractile function in Doxorubicin-induced cardiomyopathy.

  Stem cells (Dayton, Ohio) 20050101

• Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.

  Clinical & experimental metastasis 20050101

• Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes.

  Arthritis research & therapy 20050101

• Effects of water-soluble antioxidants and MAPKK/MEK inhibitor on curcumin-induced apoptosis in HL-60 human leukemic cells.

  Asian Pacific journal of cancer prevention : APJCP 20050101

• ERK-dependent signaling pathway and transcriptional factor Ets-1 regulate matrix metalloproteinase-9 production in transforming growth factor-beta1 stimulated glomerular podocytes.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101

• Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

  Respiratory research 20050101

• Effects of some new antidepressant drugs on the glucocorticoid receptor-mediated gene transcription in fibroblast cells.

  Pharmacological reports : PR 20050101

• CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells.

  Experimental & molecular medicine 20041231

• Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.

  The Journal of biological chemistry 20041217

• Phosphatidic acid and tumor necrosis factor-alpha induce the expression of CD83 through mitogen activated protein kinase pathway in a CD34+ hematopoietic progenitor cell line, KG1.

  International immunopharmacology 20041215

• Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway.

  Journal of cellular biochemistry 20041215

• Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.

  The Journal of biological chemistry 20041210

• Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II.

  Circulation research 20041210

• ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney.

  The Journal of biological chemistry 20041203

• HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner.

  The Journal of biological chemistry 20041203

• Regulation of lordosis by cyclic 3',5'-guanosine monophosphate, progesterone, and its 5alpha-reduced metabolites involves mitogen-activated protein kinase.

  Endocrinology 20041201

• Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells.

  Endocrinology 20041201

• Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

• Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells.

  International immunology 20041201

• Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

• The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury.

  Thrombosis and haemostasis 20041201

• Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity.

  Annals of the New York Academy of Sciences 20041201

• Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death.

  Neurochemical research 20041201

• Salicylic acid alters endothelin-1 binding in intact adult rat ventricular myocytes.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20041201

• Enteropathogenic Escherichia coli outer membrane proteins induce iNOS by activation of NF-kappaB and MAP kinases.

  Inflammation 20041201

• ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation.

  The Journal of biological chemistry 20041126

• p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression.

  Biochemical and biophysical research communications 20041126

• Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways.

  FEBS letters 20041119

• Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.

  Journal of medicinal chemistry 20041118

• [Activation of HIF-1 by bFGF in breast cancer: role of PI-3K and MEK1/ERK pathways].

  Zhonghua yi xue za zhi 20041117

• Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

  Blood 20041115

• Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils.

  Journal of immunology (Baltimore, Md. : 1950) 20041115

• SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.

  Cancer research 20041115

• Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041115

• Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor.

  The Journal of biological chemistry 20041112

• Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.

  Circulation research 20041112

• Plasticity in the entorhinal cortex suppresses memory for contextual fear.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

• The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.

  The Journal of pharmacology and experimental therapeutics 20041101

• Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction.

  The Journal of pharmacology and experimental therapeutics 20041101

• Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.

  American journal of physiology. Renal physiology 20041101

• Molecular dissection of the butyrate action revealed the involvement of mitogen-activated protein kinase in cystic fibrosis transmembrane conductance regulator biogenesis.

  Molecular pharmacology 20041101

• Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis.

  Laboratory investigation; a journal of technical methods and pathology 20041101

• Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures.

  Journal of neurochemistry 20041101

• Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2.

  Microvascular research 20041101

• Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production.

  Toxicology and applied pharmacology 20041101

• Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways.

  Journal of molecular and cellular cardiology 20041101

• 9HODE stimulates cell proliferation and extracellular matrix synthesis in human mesangial cells via PPARgamma.

  Experimental biology and medicine (Maywood, N.J.) 20041101

• Retinol binding protein isolated from acute renal failure patients inhibits polymorphonuclear leucocyte functions.

  European journal of clinical investigation 20041101

• Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.

  American journal of reproductive immunology (New York, N.Y. : 1989) 20041101

• Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.

  Journal of clinical immunology 20041101

• Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.

  Journal of biochemistry 20041101

• On the control of the hCYP11B2 gene expressing cytochrome P450 aldosterone synthase.

  Endocrine research 20041101

• Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.

  Journal of cardiovascular pharmacology 20041101

• Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells.

  Journal of cardiovascular pharmacology 20041101

• Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP.

  The Journal of biological chemistry 20041022

• Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts.

  The Journal of biological chemistry 20041015

• Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.

  Journal of cellular biochemistry 20041015

• Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644.

  Journal of cellular biochemistry 20041015

• Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041013

• cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK.

  The Journal of biological chemistry 20041008

• Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells.

  Journal of applied physiology (Bethesda, Md. : 1985) 20041001

• Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.

  Cellular signalling 20041001

• p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20041001

• MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury.

  Journal of cellular physiology 20041001

• Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041001

• IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways.

  Experimental cell research 20041001

• Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.

  Circulation research 20041001

• PTH and phospholipase A2 in the aging process of intestinal cells.

  Journal of cellular biochemistry 20041001

• Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.

  Amino acids 20041001

• Plasma membrane oestrogen receptor mediates neuroprotection against beta-amyloid toxicity through activation of Raf-1/MEK/ERK cascade in septal-derived cholinergic SN56 cells.

  Journal of neurochemistry 20041001

• Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.

  Cancer research 20041001

• Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts.

  Matrix biology : journal of the International Society for Matrix Biology 20041001

• Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats.

  Brain pathology (Zurich, Switzerland) 20041001

• Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.

  Molecular and cellular endocrinology 20040930

• Regulation of amphiphysin1 by mitogen-activated protein kinase: its significance in nerve growth factor receptor-mediated endocytosis.

  The Journal of biological chemistry 20040924

• Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.

  The Journal of biological chemistry 20040924

• Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040922

• Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.

  The Journal of biological chemistry 20040917

• Regulation of Gene33 expression by insulin requires MEK-ERK activation.

  Biochimica et biophysica acta 20040917

• Mitogen-activated protein kinase regulates neurofilament axonal transport.

  Journal of cell science 20040915

• Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis.

  Cancer research 20040915

• Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.

  European journal of pharmacology 20040913

• Regulation of tumor necrosis factor-alpha in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway.

  Toxicology letters 20040910

• Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptor-DNA interactions.

  Biochemical and biophysical research communications 20040910

• Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.

  Circulation 20040907

• Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.

  Carcinogenesis 20040901

• Different roles of ERK and p38 MAP kinases during tube formation from endothelial cells cultured in 3-dimensional collagen matrices.

  Journal of cellular physiology 20040901

• Differential signalling of purinoceptors in HeLa cells through the extracellular signal-regulated kinase and protein kinase C pathways.

  Journal of cellular physiology 20040901

• Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis.

  International journal of molecular medicine 20040901

• Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.

  The Journal of general virology 20040901

• Insulin stimulates endogenous angiotensin II production via a mitogen-activated protein kinase pathway in vascular smooth muscle cells.

  Journal of hypertension 20040901

• The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.

  Journal of neurochemistry 20040901

• Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.

  British journal of pharmacology 20040901

• Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.

  Molecular pharmacology 20040901

• Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

• Platelet-released supernatant increases matrix metalloproteinase-2 production, migration, proliferation, and tube formation of human umbilical vascular endothelial cells.

  Journal of periodontology 20040901

• Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.

  Circulation 20040831

• NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif.

  The Journal of biological chemistry 20040827

• Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.

  Circulation research 20040820

• Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases.

  Circulation research 20040820

• Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.

  The Journal of biological chemistry 20040813

• Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.

  The Journal of biological chemistry 20040813

• Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family.

  Life sciences 20040813

• Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.

  Toxicology 20040805

• Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung.

  Carcinogenesis 20040801

• PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair.

  Journal of cellular physiology 20040801

• Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment.

  Hypertension (Dallas, Tex. : 1979) 20040801

• Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts.

  Experimental cell research 20040801

• Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning.

  Cardiovascular research 20040801

• p38 Mitogen-activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells.

  Molecular pharmacology 20040801

• The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human keratinocytes.

  Journal of molecular medicine (Berlin, Germany) 20040801

• trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

• Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

• The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels.

  Archives of surgery (Chicago, Ill. : 1960) 20040801

• Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation.

  The Journal of biological chemistry 20040716

• Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.

  The Journal of biological chemistry 20040716

• Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.

  Blood 20040715

• Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.

  Experimental cell research 20040715

• Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.

  European journal of pharmacology 20040714

• Interleukin-8 production by THP-1 cells stimulated by Salmonella enterica serovar Typhimurium porins is mediated by AP-1, NF-kappaB and MAPK pathways.

  Cytokine 20040707

• Subcellular localization and transcriptional repressor activity of HBx on p21(WAF1/Cip1) promoter is regulated by ERK-mediated phosphorylation.

  Biochemical and biophysical research communications 20040702

• Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter.

  FEBS letters 20040702

• Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.

  Blood 20040701

• Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor.

  Endocrinology 20040701

• Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils.

  Cellular signalling 20040701

• Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells.

  Leukemia 20040701

• Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580.

  Clinical and experimental immunology 20040701

• C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.

  Drug metabolism and disposition: the biological fate of chemicals 20040701

• Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells.

  Anti-cancer drugs 20040701

• Signaling mechanisms mediated by G-protein coupled receptors in human platelets.

  Acta pharmacologica Sinica 20040701

• STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina.

  Investigative ophthalmology & visual science 20040701

• ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

  Journal of cell science 20040701

• Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kinase inhibitors.

  Cancer research 20040701

• Antiproliferative effects of Src inhibition on medullary thyroid cancer.

  The Journal of clinical endocrinology and metabolism 20040701

• Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells.

  Alimentary pharmacology & therapeutics 20040701

• The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

  The Journal of biological chemistry 20040625

• Insulin can modulate MCF-7 cell response to paclitaxel.

  Cancer letters 20040625

• Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation.

  The Journal of biological chemistry 20040618

• The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.

  The Journal of biological chemistry 20040618

• Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.

  Biochemical and biophysical research communications 20040618

• FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.

  Biochemical and biophysical research communications 20040611

• Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.

  Oncogene 20040610

• Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.

  The Journal of biological chemistry 20040604

• Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells.

  Oncogene 20040603

• Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.

  Oncogene 20040603

• Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition.

  The Journal of pharmacology and experimental therapeutics 20040601

• Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20040601

• Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK.

  Cellular signalling 20040601

• Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.

  Pharmacology 20040601

• ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells.

  International journal of oncology 20040601

• Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.

  Journal of the American Society of Nephrology : JASN 20040601

• Insulin activates native and recombinant large conductance Ca(2+)-activated potassium channels via a mitogen-activated protein kinase-dependent process.

  Molecular pharmacology 20040601

• Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha.

  Molecular and cellular biology 20040601

• Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells.

  Molecular carcinogenesis 20040601

• Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival.

  Melanoma research 20040601

• Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040601

• Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes.

  Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan 20040601

• Regulation of mRNA expression of matrix extracellular phosphoglycoprotein (MEPE)/ osteoblast/osteocyte factor 45 (OF45) by fibroblast growth factor 2 in cultures of rat bone marrow-derived osteoblastic cells.

  Endocrine 20040601

• [Mechanism of interleukin-1beta increasing growth hormone expression in rat pituitary GH3 cells].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20040601

• [Effect of EM201, an in vivo metabolite of erythromycin (EM), on signal transduction of IL-2 receptor].

  The Japanese journal of antibiotics 20040601

• Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells.

  The Journal of biological chemistry 20040521

• Regulation of the circadian oscillator in Xenopus retinal photoreceptors by protein kinases sensitive to the stress-activated protein kinase inhibitor, SB 203580.

  The Journal of biological chemistry 20040521

• Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway.

  The Journal of biological chemistry 20040521

• Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.

  Biochemical and biophysical research communications 20040521

• Mineralocorticoid receptor antagonists do not block rapid ERK activation by aldosterone.

  Biochemical and biophysical research communications 20040521

• NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway.

  FEBS letters 20040521

• Staphylococcus aureus peptidoglycan stimulates granulocyte macrophage colony-stimulating factor production from human epidermal keratinocytes via mitogen-activated protein kinases.

  FEBS letters 20040521

• Leukemia inhibitory factor activates cardiac L-Type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit.

  Circulation research 20040514

• Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.

  Circulation 20040511

• Rapid inhibition of leptin signaling by glucocorticoids in vitro and in vivo.

  The Journal of biological chemistry 20040507

• Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.

  The Journal of biological chemistry 20040507

• Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration.

  Neurochemistry international 20040501

• The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.

  Carcinogenesis 20040501

• Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor.

  Endocrinology 20040501

• Extracellular signal-regulated kinase/mitogen-activated protein kinases block internalization of delta-opioid receptors.

  The Journal of pharmacology and experimental therapeutics 20040501

• PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP.

  Cellular signalling 20040501

• The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells.

  Pflugers Archiv : European journal of physiology 20040501

• p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20040501

• Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.

  Pharmacology 20040501

• Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2alpha-induced heat shock protein 27 in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20040501

• IGF-I increases IGFBP-5 and collagen alpha1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells.

  American journal of physiology. Gastrointestinal and liver physiology 20040501

• ERK-mediated uterine artery contraction: role of thick and thin filament regulatory pathways.

  American journal of physiology. Heart and circulatory physiology 20040501

• Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.

  Biochemical pharmacology 20040501

• Tumor necrosis factor induces sodium retention in diabetic rats through sequential effects on distal tubule cells.

  Kidney international 20040501

• Role of ERK and Rho kinase pathways in central pressor action of urotensin II.

  Journal of hypertension 20040501

• Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors.

  Molecular pharmacology 20040501

• Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.

  The American journal of pathology 20040501

• Nitric oxide mediates the indole acetic acid induction activation of a mitogen-activated protein kinase cascade involved in adventitious root development.

  Plant physiology 20040501

• Differential regulation of the mitochondrial and death receptor pathways in neural stem cells.

  The European journal of neuroscience 20040501

• 1alpha,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: activation of cytosolic PLA2.

  The Journal of steroid biochemistry and molecular biology 20040501

• Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.

  European journal of pharmacology 20040426

• Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.

  Circulation research 20040416

• Cyclic AMP activation of the extracellular signal-regulated kinases 1 and 2: implications for intestinal cell survival through the transient inhibition of apoptosis.

  The Journal of biological chemistry 20040409

• Identification of proteins differentially expressed during chondrogenesis of mesenchymal cells.

  FEBS letters 20040409

• Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosis.

  Neuroreport 20040409

• Lipid rafts mediate chemotropic guidance of nerve growth cones.

  Neuron 20040408

• [Transforming growth factor beta 1 modulates connective tissue growth factor expression via Smad2 signaling pathway in podocyte in vitro].

  Zhonghua yi xue za zhi 20040402

• Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter.

  American journal of physiology. Heart and circulatory physiology 20040401

• MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation.

  Blood 20040401

• Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20040401

• Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal.

  Molecular psychiatry 20040401

• Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells.

  Chemistry and physics of lipids 20040401

• MEK/MAPK as a signaling element in ATP control of endothelial myosin light chain.

  American journal of physiology. Cell physiology 20040401

• Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.

  Biochemical pharmacology 20040401

• Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.

  Cardiovascular research 20040401

• Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells.

  Journal of cellular biochemistry 20040401

• Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.

  Journal of cellular biochemistry 20040401

• Radiation-induced up-regulation of Mmp2 involves increased mRNA stability, redox modulation, and MAPK activation.

  Radiation research 20040401

• Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation.

  Molecular pharmacology 20040401

• TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis.

  Toxicology and applied pharmacology 20040401

• Activation of the phosphatidylinositol-3' kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif.

  The Journal of endocrinology 20040401

• Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels.

  Journal of cell science 20040401

• Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel.

  Journal of cell science 20040401

• Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro.

  The European journal of neuroscience 20040401

• Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho.

  Journal of molecular and cellular cardiology 20040401

• ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells.

  Cell research 20040401

• Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity.

  Cell research 20040401

• [Effects of mitogen activated protein kinase signal transduction pathways on heat shock protein 70 gene expression in endothelial cells exposed to benzo(a)pryene].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040401

• Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.

  The Journal of biological chemistry 20040326

• Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation.

  Biochemical and biophysical research communications 20040319

• Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.

  Oncogene 20040318

• Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts.

  The Journal of biological chemistry 20040312

• Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.

  Life sciences 20040312

• Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

  Biochemical and biophysical research communications 20040312

• Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.

  Oncogene 20040311

• Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

  British journal of cancer 20040308

• Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase.

  Oncogene 20040304

• Activation of extracellular regulated kinases is required for the increase in airway epithelial permeability during leukocyte transmigration.

  American journal of respiratory cell and molecular biology 20040301

• Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.

  American journal of respiratory cell and molecular biology 20040301

• A signaling mechanism for growth-related expression of fetal hemoglobin.

  Blood 20040301

• Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin.

  Endocrinology 20040301

• Caldesmon phosphorylation is catalyzed by two kinases in permeabilized and intact vascular smooth muscle.

  Journal of cellular physiology 20040301

• PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose.

  Kidney international 20040301

• NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

  Journal of molecular and cellular cardiology 20040301

• Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.

  The Journal of endocrinology 20040301

• Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression.

  Haematologica 20040301

• Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20040301

• Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.

  Molecular and cellular biochemistry 20040301

• Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway.

  Molecular cancer research : MCR 20040301

• Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1.

  Journal of pharmacological sciences 20040301

• Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways.

  Steroids 20040301

• Fatty acids induce increased granulocyte macrophage-colony stimulating factor secretion through protein kinase C-activation in THP-1 macrophages.

  Lipids 20040301

• The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations.

  The Journal of biological chemistry 20040227

• Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.

  The Journal of biological chemistry 20040220

• Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.

  The Journal of biological chemistry 20040220

• Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation.

  Circulation research 20040220

• High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts.

  The Journal of biological chemistry 20040220

• Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells.

  Journal of cellular biochemistry 20040215

• Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20040215

• HSP25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase.

  Free radical biology & medicine 20040215

• Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

• 3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.

  International journal of cancer 20040210

• Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase.

  Biochemical and biophysical research communications 20040206

• DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung.

  American journal of physiology. Lung cellular and molecular physiology 20040201

• Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase.

  Cellular signalling 20040201

• IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.

  Cellular signalling 20040201

• Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways.

  Molecular endocrinology (Baltimore, Md.) 20040201

• Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201

• Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium.

  Laboratory investigation; a journal of technical methods and pathology 20040201

• Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Calcitonin stimulates expression of the rat 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter in HEK-293 cells expressing calcitonin receptor: identification of signaling pathways.

  Journal of molecular endocrinology 20040201

• The role of oxytocin, protein kinase A, and ERK-related MAP-kinase in the control of porcine ovarian follicle functions.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040201

• Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis.

  Stem cells and development 20040201

• Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts.

  Immunopharmacology and immunotoxicology 20040201

• Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures.

  Brain research. Developmental brain research 20040131

• 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione.

  The Journal of biological chemistry 20040130

• Anisomycin superinduces annexin V mRNA expression through the ERK1/2 but not the p38 MAP kinase pathway.

  Biochemical and biophysical research communications 20040123

• The MAP kinase pathway is required for entry into mitosis and cell survival.

  Oncogene 20040122

• Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos.

  Oncogene 20040122

• Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils.

  European journal of pharmacology 20040119

• Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.

  Biochemical and biophysical research communications 20040116

• Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells.

  Oncogene 20040115

• Low-affinity receptor-mediated induction of superoxide by N-formyl-methionyl-leucyl-phenylalanine and WKYMVm in IMR90 human fibroblasts.

  Free radical biology & medicine 20040115

• Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death.

  European journal of pharmacology 20040112

• Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.

  The Journal of biological chemistry 20040109

• Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.

  The Journal of biological chemistry 20040109

• Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.

  Cytokine 20040107

• Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases.

  American journal of physiology. Cell physiology 20040101

• Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs.

  Biology of reproduction 20040101

• Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells.

  Endocrinology 20040101

• Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells.

  Carcinogenesis 20040101

• Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases.

  The Journal of pharmacology and experimental therapeutics 20040101

• Differential induction of the expression of GST subunits by geniposide in rat hepatocytes.

  Pharmacology 20040101

• Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells.

  Experimental eye research 20040101

• MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20040101

• The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.

  Molecular carcinogenesis 20040101

• Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells.

  Cancer research 20040101

• Cerivastatin-induced apoptosis of human aortic smooth muscle cells through partial inhibition of basal activation of extracellular signal-regulated kinases.

  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20040101

• Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK.

  Molecular and cellular biochemistry 20040101

• IFN-gamma gene expression in epithelial trophectoderm cells is linked to downregulation of the p44/p42 MAP kinase pathway.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20040101

• FK506 requires stimulation of the extracellular signal-regulated kinase 1/2 and the steroid receptor chaperone protein p23 for neurite elongation.

  Neuro-Signals 20040101

• HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

• Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

• Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo.

  BMC cardiovascular disorders 20040101

• Selective inhibition of survival signal transduction pathways enhanced radiosensitivity in human esophageal cancer cell lines in vitro.

  Anticancer research 20040101

• A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation.

  Clinical & experimental metastasis 20040101

• A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway.

  Biochimie 20040101

• Characterization of Cd-induced molecular events prior to cellular damage in primary rat hepatocytes in culture: activation of the stress activated signal protein JNK and transcription factor AP-1.

  Journal of biochemical and molecular toxicology 20040101

• Prenatal exposure to high level of glucocorticoids increases the susceptibility of renal proximal tubular cells to apoptosis induced by uropathogenic Escherichia coli toxins.

  American journal of nephrology 20040101

• Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury.

  Respiratory research 20040101

• Ciliary neurotrophic factor protects rat retina cells in vitro and in vivo via PI3 kinase.

  Current eye research 20040101

• Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.

  Clinical & experimental metastasis 20040101

• ERK signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells on collagen I and vitronectin.

  Cell communication & adhesion 20040101

• Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20031226

• Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.

  The Journal of biological chemistry 20031226

• The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells.

  Oncogene 20031218

• Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion.

  Cancer research 20031215

• Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.

  Circulation research 20031212

• Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.

  Circulation research 20031212

• Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes.

  International journal of cancer 20031210

• Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways.

  Pediatric research 20031201

• Distinct molecular pathways mediate progesterone-induced growth inhibition and focal adhesion.

  Endocrinology 20031201

• Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20031201

• Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway.

  The Journal of pharmacology and experimental therapeutics 20031201

• IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.

  Cellular signalling 20031201

• Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.

  Cellular signalling 20031201

• Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2.

  Cellular signalling 20031201

• 1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.

  Cellular signalling 20031201

• Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells.

  Antioxidants & redox signaling 20031201

• The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation.

  International journal of oncology 20031201

• Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.

  International immunopharmacology 20031201

• Polyphenolic antioxidants inhibit peptide presentation by antigen-presenting cells.

  International immunopharmacology 20031201

• Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin).

  Toxicology and applied pharmacology 20031201

• Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.

  Neurochemical research 20031201

• Alternagin-C, a nonRGD-disintegrin, induces neutrophil migration via integrin signaling.

  European journal of biochemistry 20031201

• COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells.

  Digestive diseases and sciences 20031201

• Lysophosphatidic acid inhibits melanocyte proliferation via cell cycle arrest.

  Archives of pharmacal research 20031201

• N-nitrosocarbofuran induces apoptosis in mouse brain microvascular endothelial cells (bEnd.3).

  Journal of pharmacological sciences 20031201

• Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation.

  Experimental cell research 20031115

• Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.

  Brain research. Developmental brain research 20031112

• ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.

  International journal of cancer 20031110

• Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

  Cytokine 20031107

• Are changes in MAPK/ERK necessary or sufficient for entrainment in chick pineal cells?

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20031105

• Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways.

  The Journal of pharmacology and experimental therapeutics 20031101

• MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.

  Cellular signalling 20031101

• Collagen directly stimulates bladder smooth muscle cell growth in vitro: regulation by extracellular regulated mitogen activated protein kinase.

  The Journal of urology 20031101

• Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.

  International immunopharmacology 20031101

• Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells.

  Molecular pharmacology 20031101

• Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway.

  The Journal of endocrinology 20031101

• Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.

  Journal of molecular and cellular cardiology 20031101

• Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.

  Cardiovascular research 20031101

• Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.

  Journal of neurochemistry 20031101

• [Effects of Erk signal transduction on the cell cycle of rat hepatic stellate cells stimulated by acetaldehyde].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20031101

• Erythropoietin promotes resistance against the Abl tyrosine kinase inhibitor imatinib (STI571) in K562 human leukemia cells.

  Molecular cancer research : MCR 20031101

• The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.

  Breast cancer research and treatment 20031101

• The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway.

  The Journal of biological chemistry 20031031

• Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells: involvement of Rac and MAP kinase activity.

  The Journal of biological chemistry 20031017

• Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.

  Blood 20031015

• Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.

  Experimental cell research 20031015

• Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase.

  Experimental cell research 20031015

• Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells.

  Journal of immunology (Baltimore, Md. : 1950) 20031015

• Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.

  Cancer research 20031015

• The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.

  Oncogene 20031009

• Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel.

  Brain research. Molecular brain research 20031007

• Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20031003

• Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells.

  Oncogene 20031002

• Intraluminal pressure stimulates MAPK phosphorylation in arterioles: temporal dissociation from myogenic contractile response.

  American journal of physiology. Heart and circulatory physiology 20031001

• Effects of mineral trioxide aggregate (MTA) extracts on mitogen-activated protein kinase activity in human osteosarcoma cell line (U2OS).

  Biomaterials 20031001

• Role of the small GTPase Rho in modulation of the inwardly rectifying potassium channel Kir2.1.

  Molecular pharmacology 20031001

• Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.

  British journal of pharmacology 20031001

• Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase.

  Gastroenterology 20031001

• Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter.

  European journal of biochemistry 20031001

• Beta1 integrins are distributed in adhesion structures with fibronectin and caveolin and in coated pits.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20031001

• Prooxidant effects of NGF withdrawal and MEK inhibition in sympathetic neurons.

  Antioxidants & redox signaling 20031001

• Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031001

• A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation.

  Brain pathology (Zurich, Switzerland) 20031001

• Cobalt chloride-induced apoptosis and extracellular signal-regulated protein kinase activation in human cervical cancer HeLa cells.

  Journal of biochemistry and molecular biology 20030930

• Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.

  European journal of pharmacology 20030930

• Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917

• Mitogen-activated protein kinase inhibition and cardioplegia-cardiopulmonary bypass reduce coronary myogenic tone.

  Circulation 20030909

• Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains.

  Oncogene 20030904

• Air pollution particles produce airway wall remodeling in rat tracheal explants.

  American journal of respiratory cell and molecular biology 20030901

• Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.

  Blood 20030901

• PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells.

  American journal of physiology. Gastrointestinal and liver physiology 20030901

• IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.

  American journal of physiology. Lung cellular and molecular physiology 20030901

• Selectin-dependent rolling and adhesion of leukocytes in nicotine-exposed microvessels of lung allografts.

  American journal of physiology. Lung cellular and molecular physiology 20030901

• Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries.

  The Journal of physiology 20030901

• The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

  The Journal of pharmacology and experimental therapeutics 20030901

• Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.

  Cellular signalling 20030901

• 17beta-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells.

  International journal of oncology 20030901

• Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030901

• Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.

  British journal of pharmacology 20030901

• Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats.

  Pain 20030901

• Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1.

  Cardiovascular research 20030901

• Activation of mitogen-activated protein kinases during preparation of vein grafts and modulation by a synthetic inhibitor.

  The Journal of thoracic and cardiovascular surgery 20030901

• Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.

  Molecular cancer research : MCR 20030901

• Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.

  Archives of pharmacal research 20030901

• TRAIL activates a caspase 9/7-dependent pathway in caspase 8/10-defective SK-N-SH neuroblastoma cells with two functional end points: induction of apoptosis and PGE2 release.

  Neoplasia (New York, N.Y.) 20030901

• Rapamycin inhibits GM-CSF-induced neutrophil migration.

  FEBS letters 20030828

• Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

  The Journal of biological chemistry 20030822

• Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.

  Circulation research 20030822

• TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes.

  Journal of cellular biochemistry 20030815

• KCl potentiates forskolin-induced PC12 cell neurite outgrowth via protein kinase A and extracellular signal-regulated kinase signaling pathways.

  Neuroscience letters 20030814

• Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030806

• Hypertonic induction of COX-2 expression in renal medullary epithelial cells requires transactivation of the EGFR.

  American journal of physiology. Renal physiology 20030801

• Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.

  American journal of physiology. Gastrointestinal and liver physiology 20030801

• Delayed arteriolar relaxation after prolonged agonist exposure: functional remodeling involving tyrosine phosphorylation.

  American journal of physiology. Heart and circulatory physiology 20030801

• Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

  Cellular signalling 20030801

• Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway.

  Carcinogenesis 20030801

• Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells.

  Neurochemical research 20030801

• IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.

  Cell death and differentiation 20030801

• Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a phosphatidylinositol 3-kinase/AKT/p21Cip/WAF1pathway.

  Molecular pharmacology 20030801

• Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20030801

• Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3.

  Biological & pharmaceutical bulletin 20030801

• Cardiopulmonary bypass reduces peripheral microvascular contractile function by inhibition of mitogen-activated protein kinase activity.

  Surgery 20030801

• IGF-1 induces growth, survival and morphological change of primary hepatocytes on a galactose-bared polymer through both MAPK and beta-catenin pathways.

  Cell structure and function 20030801

• Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase.

  The Journal of biological chemistry 20030725

• The extracellular signal-regulated kinase cascade suppresses amyloid beta protein-induced promotion of glutamate clearance in cultured rat cortical astrocytes.

  Brain research 20030725

• Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation.

  The Journal of biological chemistry 20030718

• Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells.

  Biochemical and biophysical research communications 20030711

• Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line.

  American journal of respiratory cell and molecular biology 20030701

• Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells.

  American journal of respiratory cell and molecular biology 20030701

• PPARgamma ligand attenuates PDGF-induced mesangial cell proliferation: role of MAP kinase.

  Kidney international 20030701

• MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20030701

• Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.

  Archives of biochemistry and biophysics 20030701

• Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure.

  Developmental dynamics : an official publication of the American Association of Anatomists 20030701

• Chronic regulation of the expression of the gap junction protein connexin 43 in transfected HeLa cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20030701

• Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha.

  Cancer research 20030701

• The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.

  Cancer research 20030701

• The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells.

  The Journal of clinical endocrinology and metabolism 20030701

• Hemoglobin induces the production and release of matrix metalloproteinase-9 from human malignant cells.

  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030701

• Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages.

  Journal of cellular biochemistry 20030701

• Retinoic acid inhibits chondrogenesis of mesenchymal cells by sustaining expression of N-cadherin and its associated proteins.

  Journal of cellular biochemistry 20030701

• Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.

  Molecular carcinogenesis 20030701

• Evidence that nitroprusside stimulates glucose uptake in isolated rat cardiomyocytes via mitogen-activated protein kinase.

  Archives of physiology and biochemistry 20030701

• p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

  The Journal of biological chemistry 20030627

• ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

  Oncogene 20030626

• Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways.

  Biochemistry 20030624

• Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.

  International journal of cancer 20030620

• The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB.

  Life sciences 20030620

• TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase.

  Biochemical and biophysical research communications 20030620

• High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life.

  Journal of the American College of Cardiology 20030618

• Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.

  Circulation 20030617

• Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.

  The Biochemical journal 20030615

• Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status.

  Free radical biology & medicine 20030615

• Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells.

  Journal of immunology (Baltimore, Md. : 1950) 20030615

• Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.

  Journal of immunology (Baltimore, Md. : 1950) 20030615

• ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway.

  The Journal of biological chemistry 20030613

• The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair.

  The Journal of biological chemistry 20030606

• Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20030601

• Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons.

  Journal of neurophysiology 20030601

• p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts.

  American journal of physiology. Endocrinology and metabolism 20030601

• Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.

  Arteriosclerosis, thrombosis, and vascular biology 20030601

• Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway.

  Fungal genetics and biology : FG & B 20030601

• Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells.

  Endocrinology 20030601

• The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development.

  Journal of neurochemistry 20030601

• Regulation of melanosome movement by MAP kinase.

  Pigment cell research 20030601

• Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.

  Molecular pharmacology 20030601

• The role of H2O2 as a mediator of UVB-induced apoptosis in keratinocytes.

  Free radical research 20030601

• Androgen and the blocking of radiation-induced sensitization to Fas-mediated apoptosis through c-jun induction in prostate cancer cells.

  International journal of radiation biology 20030601

• Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.

  The Journal of biological chemistry 20030530

• An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells.

  Biochemical and biophysical research communications 20030530

• Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling.

  The Journal of biological chemistry 20030523

• Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity.

  The Journal of biological chemistry 20030523

• Sodium orthovanadate potentiates EGCG-induced apoptosis that is dependent on the ERK pathway.

  Biochemical and biophysical research communications 20030523

• Characterization of bradykinin-induced prostaglandin E2 release from cultured rat trigeminal ganglion neurones.

  European journal of pharmacology 20030523

• Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.

  International journal of cancer 20030520

• Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.

  The Journal of biological chemistry 20030516

• Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.

  The Journal of biological chemistry 20030516

• Role of redox signaling in the autonomous proliferative response of endothelial cells to hypoxia.

  Circulation research 20030516

• The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells.

  Life sciences 20030516

• Cyclic AMP-dependent protein kinase A and CREB are involved in neuregulin-induced synapse-specific expression of acetylcholine receptor gene.

  Biochemical and biophysical research communications 20030516

• Urokinase-type plasminogen activator receptor crosslinking in an NK cell line increases integrin surface expression by the MAP kinase/ERK 1/2 signaling pathway.

  Journal of cellular biochemistry 20030515

• Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c.

  Journal of neuroscience research 20030515

• Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA.

  Journal of immunology (Baltimore, Md. : 1950) 20030515

• AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation.

  Toxicology and applied pharmacology 20030515

• Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells.

  Blood 20030501

• Epidermal-growth-factor receptor and metalloproteinases mediate thromboxane A2-dependent extracellular-signal-regulated kinase activation.

  The Biochemical journal 20030501

• Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

• Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation.

  Journal of cell science 20030501

• Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.

  American journal of physiology. Lung cellular and molecular physiology 20030501

• Destabilization of Na(v)1.7 sodium channel alpha-subunit mRNA by constitutive phosphorylation of extracellular signal-regulated kinase: negative regulation of steady-state level of cell surface functional sodium channels in adrenal chromaffin cells.

  Molecular pharmacology 20030501

• Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells.

  The American journal of pathology 20030501

• NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.

  Journal of hypertension 20030501

• Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030501

• Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1.

  The Journal of clinical endocrinology and metabolism 20030501

• Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-E1 osteoblast-like cells.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030501

• Enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: role of the ERK-MAP kinase signal transduction cascade.

  British journal of pharmacology 20030501

• In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia.

  Leukemia 20030501

• Mechanisms involved in the stimulation of prostacyclin synthesis by human lymphocytes in human umbilical vein endothelial cells.

  British journal of pharmacology 20030501

• Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.

  Cellular immunology 20030501

• Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.

  The Journal of biological chemistry 20030418

• Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.

  European journal of pharmacology 20030418

• Downstream effectors of oncogenic ras in multiple myeloma cells.

  Blood 20030415

• Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells.

  Journal of cellular biochemistry 20030415

• ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis.

  The Journal of biological chemistry 20030411

• Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate.

  Biochemical and biophysical research communications 20030411

• Kinase inhibitors: not just for kinases anymore.

  Journal of medicinal chemistry 20030410

• Signalling pathways involved in the short-term potentiation of dopamine release by BDNF.

  Brain research 20030404

• Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro.

  American journal of physiology. Heart and circulatory physiology 20030401

• MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons.

  Journal of neurobiology 20030401

• Basic fibroblast growth factor induces the expression of matrix metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway.

  Journal of periodontal research 20030401

• Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors.

  Endocrinology 20030401

• Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.

  Molecular pharmacology 20030401

• Leptin induces mitogenic effect on human choriocarcinoma cell line (JAr) via MAP kinase activation in a glucose-dependent fashion.

  Placenta 20030401

• Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis.

  Investigative ophthalmology & visual science 20030401

• Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells.

  The Journal of laboratory and clinical medicine 20030401

• Prostaglandin (PG) F(2alpha) receptor expression and signaling in human endometrium: role of PGF(2alpha) in epithelial cell proliferation.

  The Journal of clinical endocrinology and metabolism 20030401

• The p42/44mitogen-activated protein kinase inhibitor PD 98059, but not U 0126, increases a K+ current in cardiomyocytes.

  Clinical and experimental pharmacology & physiology 20030401

• Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401

• The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.

  Antioxidants & redox signaling 20030401

• Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase.

  Cellular and molecular life sciences : CMLS 20030401

• Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells.

  The Journal of biological chemistry 20030328

• LPS regulate ERK1/2-dependent signaling in cardiac fibroblasts via PKC-mediated MKP-1 induction.

  Biochemical and biophysical research communications 20030328

• Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.

  Oncogene 20030327

• Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.

  The Journal of biological chemistry 20030321

• Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

  The EMBO journal 20030317

• Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.

  Cancer research 20030315

• Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030315

• Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1.

  The Journal of biological chemistry 20030314

• Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line.

  International journal of cancer 20030310

• Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase.

  The Journal of biological chemistry 20030307

• Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.

  Oncogene 20030306

• Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.

  Molecular endocrinology (Baltimore, Md.) 20030301

• Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells.

  Endocrinology 20030301

• Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.

  American journal of respiratory cell and molecular biology 20030301

• p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene.

  The Journal of investigative dermatology 20030301

• Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.

  Molecular pharmacology 20030301

• The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.

  Molecular and cellular biology 20030301

• Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis.

  Molecular carcinogenesis 20030301

• Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2.

  Carcinogenesis 20030301

• Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.

  Bone 20030301

• Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.

  Neuropharmacology 20030301

• Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.

  The Journal of biological chemistry 20030227

• IGF-1 receptor mediates differentiation of primary cultures of mouse skeletal myoblasts.

  Molecular and cellular endocrinology 20030227

• Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells.

  Molecular and cellular endocrinology 20030227

• Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.

  The Journal of biological chemistry 20030221

• Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5.

  Biochemical and biophysical research communications 20030221

• Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells.

  European journal of pharmacology 20030221

• ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.

  Oncogene 20030220

• Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.

  Oncogene 20030220

• The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation.

  Blood 20030215

• Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin.

  Blood 20030215

• Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.

  The Journal of biological chemistry 20030214

• Bone morphogenetic protein signaling in articular chondrocyte differentiation.

  Biochemical and biophysical research communications 20030207

• Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.

  European journal of pharmacology 20030207

• Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

• Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation.

  Basic research in cardiology 20030201

• Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differently.

  Journal of cell science 20030201

• Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

• Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201

• Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle.

  Reproduction (Cambridge, England) 20030201

• Matrix metalloproteinase production by COOH-terminal heparin-binding fibronectin fragment in rheumatoid synovial cells.

  Laboratory investigation; a journal of technical methods and pathology 20030201

• CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I.

  European journal of immunology 20030201

• Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.

  The Tohoku journal of experimental medicine 20030201

• Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.

  Cancer science 20030201

• ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries.

  Archives of physiology and biochemistry 20030201

• Effects of chronic ethanol treatment on the angiotensin II-mediated p42/p44 mitogen-activated protein kinase and phosphorylase a activation in rat hepatocytes.

  Alcohol (Fayetteville, N.Y.) 20030201

• Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells.

  Biochemical and biophysical research communications 20030131

• Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.

  Transplantation 20030127

• ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin.

  The Journal of biological chemistry 20030117

• A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis.

  The Journal of biological chemistry 20030117

• Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.

  Oncogene 20030116

• Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115

• Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

  Cancer research 20030115

• Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.

  The Journal of biological chemistry 20030110

• Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines.

  International journal of cancer 20030110

• Molecular mechanisms of L-selectin-induced co-localization in rafts and shedding [corrected].

  Biochemical and biophysical research communications 20030110

• Stretch enhances contraction of bovine coronary arteries via an NAD(P)H oxidase-mediated activation of the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.

  Circulation research 20030110

• Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway.

  Cellular signalling 20030101

• Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in capillary endothelial cells.

  International journal of oncology 20030101

• Cyclic AMP induces activation of extracellular signal-regulated kinases in HL-60 cells: role in cAMP-induced differentiation.

  Leukemia research 20030101

• Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.

  Cell and tissue research 20030101

• Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway.

  Endocrinology 20030101

• Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.

  European journal of biochemistry 20030101

• Expression pattern and role of a 60-kilodalton progesterone binding protein in regulating granulosa cell apoptosis: involvement of the mitogen-activated protein kinase cascade.

  Biology of reproduction 20030101

• Adenosine triphosphate activates mitogen-activated protein kinase in pre-neoplastic and neoplastic ovarian surface epithelial cells.

  Biology of reproduction 20030101

• Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.

  Diabetes 20030101

• [G-protein-coupled muscarinic acetylcholine receptor activation up-regulates Bcl-2 and phospho-bad via Ras-ERK-1/2 signaling pathway].

  Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030101

• Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity.

  Carcinogenesis 20030101

• Suppression of tumor necrosis factor-alpha by beta2-adrenoceptor activation: role of mitogen-activated protein kinases in renal mesangial cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030101

• Formation of AP-1 transcription factors during learning in Helix.

  Neuroscience and behavioral physiology 20030101

• Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase.

  Molecular and cellular biochemistry 20030101

• Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells.

  Chemical research in toxicology 20030101

• A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.

  Neuroscience 20030101

• Mediation of cadmium-induced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion.

  Journal of biochemical and molecular toxicology 20030101

• Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase.

  BMC neuroscience 20030101

• Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.

  Neuroscience 20030101

• Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor.

  Oncology reports 20030101

• Effects of 1alpha,25-dihydroxy-vitamin D3 pretreatment and MAP kinase inhibitor PD 98059 on response of osteoblasts to prostate-derived osteoblastic factors.

  Oncology reports 20030101

• TGFbeta1 signaling via alphaVbeta6 integrin.

  Molecular cancer 20030101

• The effect of mycobacterial virulence and viability on MAP kinase signalling and TNF alpha production by human monocytes.

  Tuberculosis (Edinburgh, Scotland) 20030101

• Distinct roles of p42/p44(ERK) and p38 MAPK in oxidant-induced AP-1 activation and cardiomyocyte hypertrophy.

  Cardiovascular toxicology 20030101

• Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro.

  Neuroscience 20030101

• Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20030101

• Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.

  Endothelium : journal of endothelial cell research 20030101

• Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein.

  Hippocampus 20030101

• Limitation of myocardial reperfusion injury by AMP579, an adenosine A1/A2A receptor agonist: role of A2A receptor and Erk1/2.

  Cardiovascular drugs and therapy 20030101

• Regulation of Na(+)-K(+)-2Cl- cotransporter activity in rat skeletal muscle and intestinal epithelial cells.

  Tsitologiia 20030101

• Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins.

  The Journal of biological chemistry 20021220

• Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT/enhancer-binding protein-beta binding via a common signaling pathway.

  The Journal of biological chemistry 20021220

• Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.

  The Journal of biological chemistry 20021220

• Bcl-2 up-regulates ha-ras mRNA expression and induces c-Jun phosphorylation at Ser73 via an ERK-dependent pathway in PC 12 cells.

  Neuroreport 20021220

• Antioxidants induce different phenotypes by a distinct modulation of signal transduction.

  FEBS letters 20021218

• Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats.

  Biochemical and biophysical research communications 20021206

• Nuclear localisation of cytosolic phospholipase A2-alpha in the EA.hy.926 human endothelial cell line is proliferation dependent and modulated by phosphorylation.

  Journal of cell science 20021201

• Agonists of proteinase-activated receptor 2 induce TNF-alpha secretion from astrocytoma cells.

  Cell biochemistry and function 20021201

• Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.

  Experimental brain research 20021201

• CCL20/macrophage inflammatory protein-3alpha production in LPS-stimulated neutrophils is enhanced by the chemoattractant formyl-methionyl-leucyl-phenylalanine and IFN-gamma through independent mechanisms.

  European journal of immunology 20021201

• Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.

  American journal of respiratory cell and molecular biology 20021201

• Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway.

  Biology of reproduction 20021201

• Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20021201

• Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells.

  Endocrinology 20021201

• Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter.

  Molecular endocrinology (Baltimore, Md.) 20021201

• Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells.

  Diabetes 20021201

• Mixed lineage kinase 3 inhibits phorbol myristoyl acetate-induced DNA synthesis but not osteopontin expression in rat mesangial cells.

  Molecular and cellular biochemistry 20021201

• Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells.

  Chemical research in toxicology 20021201

• Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells.

  Journal of Korean medical science 20021201

• Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endothelium.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20021201

• Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation.

  Genes to cells : devoted to molecular & cellular mechanisms 20021201

• Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway.

  Cellular immunology 20021201

• Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibers.

  The Journal of biological chemistry 20021129

• Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells.

  Life sciences 20021122

• Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells.

  Oncogene 20021121

• Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

  The Biochemical journal 20021115

• Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway.

  The Journal of biological chemistry 20021115

• Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.

  The Biochemical journal 20021101

• Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021101

• Redistribution of ERK/MAP kinase to uropod-like structures in interleukin-3-induced cell shape changes.

  Immunology letters 20021101

• Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells.

  American journal of physiology. Cell physiology 20021101

• Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway.

  Blood 20021101

• 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

  Journal of immunology (Baltimore, Md. : 1950) 20021101

• Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons.

  Molecular pharmacology 20021101

• Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.

  Hypertension (Dallas, Tex. : 1979) 20021101

• The role of MAPK pathways in the action of chemotherapeutic drugs.

  Carcinogenesis 20021101

• Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure.

  Neuropharmacology 20021101

• Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell.

  Journal of cancer research and clinical oncology 20021101

• Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells.

  Toxicology and applied pharmacology 20021101

• Participation of various kinases in staurosporine induced apoptosis of RAW 264.7 cells.

  The Journal of pharmacy and pharmacology 20021101

• Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.

  Endocrine 20021101

• Involvement of Ras in survival responsiveness to nitric oxide toxicity in pheochromocytoma cells.

  Journal of neuro-oncology 20021101

• [The effect of metallothionein on delaying protection of ischemia/reperfusion].

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20021101

• Acute exposure of toluene transiently potentiates p42/44 mitogen-activated protein kinase (MAPK) activity in cultured rat cortical astrocytes.

  Neuroscience letters 20021031

• Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide.

  Neuroscience letters 20021031

• [Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide].

  Zhonghua yi xue za zhi 20021025

• Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.

  Experimental cell research 20021015

• Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20021011

• Regulation of mdm2 mRNA expression in human breast tumor-derived GI-101A cells.

  Life sciences 20021004

• Effects of beta-endorphin and Naloxone on in vitro maturation of bovine oocytes.

  Molecular reproduction and development 20021001

• Dietary salt intake activates MAP kinases in the rat kidney.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• MEK and ERK inhibitors enhance the anti-proliferative effect of interferon-alpha2b.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).

  Journal of cellular physiology 20021001

• Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation.

  American journal of physiology. Lung cellular and molecular physiology 20021001

• Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.

  American journal of physiology. Heart and circulatory physiology 20021001

• Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells.

  Gut 20021001

• Tonic inhibitory role for cAMP in alpha(1a)-adrenergic receptor coupling to extracellular signal-regulated kinases 1/2.

  The Journal of pharmacology and experimental therapeutics 20021001

• Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.

  British journal of pharmacology 20021001

• Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.

  Molecular pharmacology 20021001

• Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

  Endocrinology 20021001

• Regulation of gonadotropin alpha subunit gene expression by dopamine D(2) receptor agonist in clonal mouse gonadotroph alphaT3-1 cells.

  Biology of reproduction 20021001

• Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP.

  Diabetes 20021001

• Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.

  Cancer research 20021001

• Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021001

• Cerulein-induced acute pancreatitis in the rat is significantly ameliorated by treatment with MEK1/2 inhibitors U0126 and PD98059.

  Pancreas 20021001

• Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

• Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases.

  Toxicological sciences : an official journal of the Society of Toxicology 20021001

• The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.

  Molecular medicine (Cambridge, Mass.) 20021001

• Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.

  Molecular cancer therapeutics 20021001

• 2',5'-Dihydroxychalcone down-regulates endothelial connexin43 gap junctions and affects MAP kinase activation.

  Toxicology 20020930

• Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells.

  The Journal of biological chemistry 20020927

• Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization.

  FEBS letters 20020925

• [Effect of mitogen-activated protein kinase signal transduction in non-estrogen antagonistic mechanism of tamoxifen].

  Zhonghua yi xue za zhi 20020925

• Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro.

  Biochemical and biophysical research communications 20020920

• Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway.

  Gene 20020918

• Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.

  Cellular signalling 20020901

• Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol.

  Endocrinology 20020901

• Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.

  Molecular human reproduction 20020901

• Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.

  Molecular carcinogenesis 20020901

• The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells.

  American journal of respiratory cell and molecular biology 20020901

• Insulin-like growth factor-I inhibits cell growth in the a549 non-small lung cancer cell line.

  American journal of respiratory cell and molecular biology 20020901

• Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.

  European journal of immunology 20020901

• Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function.

  Biochemical pharmacology 20020901

• Regulation of ionomycin-mediated granule release from rat basophil leukemia cells.

  Molecular immunology 20020901

• Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.

  Experimental hematology 20020901

• Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts.

  Arthritis and rheumatism 20020901

• Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020901

• Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

  Oncogene 20020829

• Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.

  International journal of cancer 20020820

• Involvement of mitogen protein kinase cascade in agonist-mediated human A(3) adenosine receptor regulation.

  Biochimica et biophysica acta 20020819

• Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes.

  Brain research 20020816

• Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes.

  Biochemical and biophysical research communications 20020816

• Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy.

  Biochemical and biophysical research communications 20020816

• Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways.

  European journal of pharmacology 20020816

• Evidence that inhibition of p44/42 mitogen-activated protein kinase signaling is a factor in proteasome inhibitor-mediated apoptosis.

  The Journal of biological chemistry 20020802

• Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20020802

• Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.

  The Biochemical journal 20020801

• Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.

  American journal of physiology. Gastrointestinal and liver physiology 20020801

• A mitogen-activated protein kinase is involved in the inotropic but not chronotropic actions of adrenoceptor agonists and endothelin-1.

  Naunyn-Schmiedeberg's archives of pharmacology 20020801

• Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.

  The Journal of urology 20020801

• Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.

  Hepatology (Baltimore, Md.) 20020801

• Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization.

  Journal of leukocyte biology 20020801

• Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.

  Hypertension (Dallas, Tex. : 1979) 20020801

• Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion.

  Journal of neurophysiology 20020801

• Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.

  The Journal of endocrinology 20020801

• Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.

  European journal of biochemistry 20020801

• Dual role of protein kinase C on mitogen-activated protein kinase activation and human keratinocyte proliferation.

  Experimental dermatology 20020801

• Differential roles of SOCS family members in EpoR signal transduction.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020801

• Metalloproteinases stimulate ErbB-dependent ERK signaling in human skin organ culture.

  The Journal of biological chemistry 20020726

• VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.

  The Journal of biological chemistry 20020726

• Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.

  Experimental cell research 20020715

• Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715

• The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.

  Archives of biochemistry and biophysics 20020715

• Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation.

  The Journal of biological chemistry 20020705

• Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis.

  American journal of physiology. Lung cellular and molecular physiology 20020701

• Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis.

  American journal of physiology. Gastrointestinal and liver physiology 20020701

• Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.

  The Journal of pharmacology and experimental therapeutics 20020701

• The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure.

  Molecular pharmacology 20020701

• Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch.

  American journal of respiratory cell and molecular biology 20020701

• Cellular prion protein transduces neuroprotective signals.

  The EMBO journal 20020701

• Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.

  The EMBO journal 20020701

• Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases.

  Shock (Augusta, Ga.) 20020701

• The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability.

  Shock (Augusta, Ga.) 20020701

• Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.

  International immunology 20020701

• Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.

  Archives of dermatological research 20020701

• Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020701

• The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide.

  Carcinogenesis 20020701

• Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.

  Toxicology and applied pharmacology 20020701

• Neutral endopeptidase/CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C- and extracellular signal-regulated kinase-dependent signalling pathway.

  Placenta 20020701

• Activation of Raf-1/MEK-1/2/p42/44(MAPK) cascade alone is sufficient to uncouple LDL receptor expression from cell growth.

  Molecular and cellular biochemistry 20020701

• Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.

  Leukemia & lymphoma 20020701

• Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.

  Molecular cancer therapeutics 20020701

• Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.

  The Journal of biological chemistry 20020628

• Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.

  Oncogene 20020627

• Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.

  The Journal of biological chemistry 20020621

• Co-requirement of cyclic AMP- and calcium-dependent protein kinases for transcriptional activation of cholecystokinin gene by protein hydrolysates.

  The Journal of biological chemistry 20020621

• Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB.

  Biochemical and biophysical research communications 20020621

• Activation of extracellular signal-regulated kinases is essential for pressure-induced proliferation of vascular smooth muscle cells.

  European journal of pharmacology 20020620

• AP-1 activation through endogenous H(2)O(2) generation by alveolar macrophages.

  Free radical biology & medicine 20020615

• Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

  FEBS letters 20020605

• IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20020601

• Endocrine disrupter bisphenol a induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells.

  Endocrinology 20020601

• Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells.

  The Journal of pharmacology and experimental therapeutics 20020601

• Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.

  Genes & development 20020601

• Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.

  Archives of biochemistry and biophysics 20020601

• PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.

  Journal of molecular and cellular cardiology 20020601

• Interferon-beta activates multiple signaling cascades in primary human microglia.

  Journal of neurochemistry 20020601

• Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways.

  The Journal of biological chemistry 20020531

• Loss of plasma membrane phospholipid asymmetry requires raft integrity. Role of transient receptor potential channels and ERK pathway.

  The Journal of biological chemistry 20020531

• Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells.

  The Journal of biological chemistry 20020531

• Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts.

  Oncogene 20020530

• Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.

  Cancer letters 20020528

• Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells.

  The Journal of biological chemistry 20020524

• Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes.

  Neuroscience letters 20020524

• PPAR activators inhibit endothelial cell migration by targeting Akt.

  Biochemical and biophysical research communications 20020524

• Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

  The Journal of biological chemistry 20020503

• Signaling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of stress-activated p38 MAP kinases.

  Developmental and comparative immunology 20020501

• Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20020501

• Characterization of the increase in bone 66 kDa protein component with healing rat fractures: stimulatory effect of zinc.

  International journal of molecular medicine 20020501

• Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.

  Molecular pharmacology 20020501

• Regulation of translation during in vitro maturation of bovine oocytes: the role of MAP kinase, eIF4E (cap binding protein) phosphorylation, and eIF4E-BP1.

  Biology of reproduction 20020501

• Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

  The EMBO journal 20020501

• Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death.

  Anesthesiology 20020501

• Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells.

  Hepatology (Baltimore, Md.) 20020501

• Induction of plasminogen activator inhibitor-1 in endothelial cells by basic fibroblast growth factor and its modulation by fibric acid.

  Arteriosclerosis, thrombosis, and vascular biology 20020501

• Immunomodulatory effect of oxygen and pressure.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020501

• Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activated protein kinase pathway activation and induction of hexokinase II expression.

  The Journal of biological chemistry 20020426

• Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation.

  Biochemical and biophysical research communications 20020426

• Molecular crosstalk between p70S6k and MAPK cell signaling pathways.

  Biochemical and biophysical research communications 20020426

• KCl activates mitogen-activated protein kinase in rabbit bailar artery.

  Biochemical and biophysical research communications 20020426

• Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells.

  Biochimica et biophysica acta 20020424

• Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.

  The Journal of biological chemistry 20020419

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Suppression of IL-12 production by soluble CD40 ligand: evidence for involvement of the p44/42 mitogen-activated protein kinase pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20020415

• Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation.

  Biochemical pharmacology 20020415

• Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.

  The Journal of biological chemistry 20020405

• Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.

  The Journal of biological chemistry 20020405

• Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis.

  The Journal of biological chemistry 20020405

• Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes.

  The Journal of biological chemistry 20020405

• Bisperoxovanadium complex promotes dopamine exocytosis in PC12 cells.

  Neurochemistry international 20020401

• IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway.

  The international journal of biochemistry & cell biology 20020401

• Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms.

  Cellular signalling 20020401

• Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney.

  American journal of physiology. Renal physiology 20020401

• Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor.

  Molecular pharmacology 20020401

• Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20020401

• Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.

  Free radical biology & medicine 20020401

• Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells.

  British journal of haematology 20020401

• Thrombin-receptor activation and thrombin-induced brain tolerance.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020401

• Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.

  Molecular endocrinology (Baltimore, Md.) 20020401

• Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.

  Molecular endocrinology (Baltimore, Md.) 20020401

• Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1MF-2 smooth muscle cells.

  British journal of pharmacology 20020401

• Inhibition of IL-8-mediated MAPK activation in human neutrophils by beta1 integrin ligands.

  Inflammation 20020401

• Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study.

  Cardiovascular research 20020401

• Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism.

  In vitro cellular & developmental biology. Animal 20020401

• Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.

  Experimental & molecular medicine 20020331

• The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.

  The Journal of biological chemistry 20020329

• Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats.

  Molecular and cellular endocrinology 20020328

• Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.

  Oncogene 20020327

• Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells.

  The Journal of biological chemistry 20020322

• IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.

  Biochemical and biophysical research communications 20020322

• Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.

  Life sciences 20020322

• Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.

  The Journal of biological chemistry 20020315

• Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.

  The Journal of biological chemistry 20020315

• Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.

  Synapse (New York, N.Y.) 20020315

• Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.

  The Biochemical journal 20020315

• Lack of involvement of extracellular signal-regulated kinase (ERK) in the agonist-induced endothelial nitric oxide synthesis.

  Biochemical pharmacology 20020315

• Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells.

  Biochimica et biophysica acta 20020315

• Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways.

  The Journal of biological chemistry 20020308

• Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis.

  The Journal of biological chemistry 20020308

• Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.

  European journal of pharmacology 20020308

• Role of MAPK in chronic cerebral vasospasm.

  Life sciences 20020308

• ERK and p38 MAP kinase are involved in arachidonic acid release induced by H(2)O(2) and PDGF in mesangial cells.

  American journal of physiology. Renal physiology 20020301

• PTH and DA regulate Na-K ATPase through divergent pathways.

  American journal of physiology. Renal physiology 20020301

• Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset.

  American journal of physiology. Lung cellular and molecular physiology 20020301

• STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.

  Kidney international 20020301

• Regulation of cyclooxygenase-2 expression by phospholipase D in human amnion-derived WISH cells.

  Molecular pharmacology 20020301

• Differential role of MAP kinases in stimulation of hepatocyte growth by EGF and G-protein-coupled receptor agonists.

  Biochemical and biophysical research communications 20020301

• Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism.

  The Journal of pharmacology and experimental therapeutics 20020301

• Lysophosphatidylcholine is a major contributor to the synergistic effect of mildly oxidized low-density lipoprotein with endothelin-1 on vascular smooth muscle cell proliferation.

  Journal of cardiovascular pharmacology 20020301

• Extracellular signal-regulated kinase plays an essential role in endothelin-1-induced homotypic adhesion of human neutrophil granulocytes.

  British journal of pharmacology 20020301

• Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.

  The Journal of clinical endocrinology and metabolism 20020301

• Glucocorticoids induced the production and gene expression of IL-1alpha through AP-1 and partially NF-kappaB activation in murine epidermal cells.

  Journal of medical and dental sciences 20020301

• Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.

  Molecular cancer therapeutics 20020301

• Expression of p21WAF1 is dependent on the activation of ERK during vitamin E-succinate-induced monocytic differentiation.

  Molecules and cells 20020227

• Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.

  The Journal of biological chemistry 20020215

• Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.

  Experimental cell research 20020215

• Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.

  Biochimica et biophysica acta 20020213

• Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta and ERK.

  Biochimica et biophysica acta 20020213

• Induction of uPA but not NF-IL3A by calcitonin is dependent on Erk1/2 phosphorylation in porcine renal cell line LLC-PK1.

  Biochemical and biophysical research communications 20020208

• Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation.

  American journal of physiology. Heart and circulatory physiology 20020201

• UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.

  American journal of physiology. Heart and circulatory physiology 20020201

• Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.

  American journal of physiology. Renal physiology 20020201

• Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage.

  The Biochemical journal 20020201

• Interferon-gamma inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells: upregulation of p27(kip1) cyclin-dependent kinase inhibitor.

  American journal of respiratory cell and molecular biology 20020201

• Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020201

• Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

  Cardiovascular research 20020201

• Ambroxol inhibits platelet-derived growth factor production in human monocytic cells.

  European journal of pharmacology 20020201

• Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.

  The Journal of endocrinology 20020201

• Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner.

  The Journal of endocrinology 20020201

• Apoptosis coincident with the differentiation of skeletal myoblasts is delayed by caspase 3 inhibition and abrogated by MEK-independent constitutive Ras signaling.

  Cell death and differentiation 20020201

• Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.

  European journal of biochemistry 20020201

• p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.

  Neurobiology of disease 20020201

• Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin.

  Biochemical pharmacology 20020201

• Potential signalling pathways underlying corticotrophin-releasing hormone-mediated neuroprotection from excitotoxicity in rat hippocampus.

  Journal of neurochemistry 20020201

• Extracellular signal-regulated kinase activation involved in human sperm-zona pellucida binding.

  Andrologia 20020201

• ERK MAP Kinase is required in 1,25(OH)2D3-induced differentiation in human osteoblasts.

  Immunopharmacology and immunotoxicology 20020201

• The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade.

  The Journal of biological chemistry 20020125

• Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells.

  European journal of pharmacology 20020125

• Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene.

  Oncogene 20020124

• Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

  Journal of medicinal chemistry 20020117

• Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells.

  The Journal of biological chemistry 20020111

• High glucose induced VEGF expression via PKC and ERK in glomerular podocytes.

  Biochemical and biophysical research communications 20020111

• Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein.

  Biochemical and biophysical research communications 20020111

• Secretory phospholipase A(2) elicits proinflammatory changes and upregulates the surface expression of fas ligand in monocytic cells: potential relevance for atherogenesis.

  Circulation research 20020111

• Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.

  Oncogene 20020103

• Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020101

• c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells.

  Leukemia research 20020101

• Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes.

  American journal of physiology. Cell physiology 20020101

• ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy.

  American journal of physiology. Heart and circulatory physiology 20020101

• Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes.

  Neuropharmacology 20020101

• IL-1alpha stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways.

  Journal of biochemistry 20020101

• Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages.

  Atherosclerosis 20020101

• Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation.

  Molecular endocrinology (Baltimore, Md.) 20020101

• Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.

  European journal of biochemistry 20020101

• The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.

  Bone 20020101

• Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes.

  Journal of hepatology 20020101

• Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.

  Journal of molecular and cellular cardiology 20020101

• Noradrenaline-induced paxillin phosphorylation, ERK activation and MEK-regulated contraction in intact rat mesenteric arteries.

  Journal of vascular research 20020101

• Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors.

  Gene therapy 20020101

• Vanadate increases glucocorticoid receptor-mediated gene expression: a novel mechanism for potentiation of a steroid receptor.

  The Journal of steroid biochemistry and molecular biology 20020101

• A role for MAP kinase in the antitumor activity of a nucleoside analog.

  Cancer gene therapy 20020101

• Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3.

  Neoplasia (New York, N.Y.) 20020101

• Mitogen activated protein kinase activation and oxidant signaling in astrocytoma cells.

  Journal of neuro-oncology 20020101

• Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases.

  Anticancer research 20020101

• Oxidized low-density lipoproteins potentiate the mitogenic effect of 5-hydroxytryptamine on vascular smooth muscle cells.

  Japanese heart journal 20020101

• Hepatocyte growth factor upregulates alpha2beta1 integrin in Madin-Darby canine kidney cells: implications in tubulogenesis.

  Journal of biomedical science 20020101

• High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.

  Journal of cellular biochemistry 20020101

• Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20020101

• Differential role of hydrogen peroxide in UV-induced signal transduction.

  Molecular and cellular biochemistry 20020101

• Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.

  Acta neurochirurgica. Supplement 20020101

• Diet restriction impairs extracellular signal-regulated kinase activation of peritoneal exudative cells after N-formyl-methionyl-leucyl-phenylalanine stimulation in a murine peritonitis model.

  JPEN. Journal of parenteral and enteral nutrition 20020101

• Cell-based studies reveal differences in glutathione S-transferase induction between oltipraz and tert-butylhydroquinone.

  Journal of biochemical and molecular toxicology 20020101

• Mechanism of down-regulation of L-type Ca(2+) channel in the proliferating smooth muscle cells of rat aorta.

  Journal of cellular biochemistry 20020101

• [Transformation with the E1A + cHa-ras oncogenes enhances the trans-repressor function of the Elk-1 transcription factor].

  Molekuliarnaia biologiia 20020101

• Role of endogenous regucalcin in nuclear regulation of regenerating rat liver: suppression of the enhanced ribonucleic acid synthesis activity.

  Journal of cellular biochemistry 20020101

• Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.

  Cancer biology & therapy 20020101

• Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction.

  Journal of experimental therapeutics & oncology 20020101

• IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells.

  Folia histochemica et cytobiologica 20020101

• Modulation of ornithine decarboxylase activity and mitogen-activated protein kinases in protocatechualdehyde-induced apoptosis of CTLL-2 cells.

  Anticancer research 20020101

• Mitogen-activated protein kinase inhibitor, PD98059, inhibits rat retinal pigment epithelial cell replication by cell cycle arrest.

  Japanese journal of ophthalmology 20020101

• Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.

  Experimental & molecular medicine 20011231

• Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.

  The Journal of biological chemistry 20011228

• 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.

  The Journal of biological chemistry 20011228

• Phosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activity.

  The Biochemical journal 20011215

• The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20011214

• Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells.

  The Journal of biological chemistry 20011214

• Signals via FGF receptor 2 regulate migration of endothelial cells.

  Biochemical and biophysical research communications 20011214

• Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.

  Oncogene 20011206

• Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201

• Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line.

  American journal of physiology. Cell physiology 20011201

• TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms.

  American journal of physiology. Gastrointestinal and liver physiology 20011201

• Role of reactive oxygen species in IL-1 beta-stimulated sustained ERK activation and MMP-9 induction.

  American journal of physiology. Heart and circulatory physiology 20011201

• Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein.

  American journal of physiology. Heart and circulatory physiology 20011201

• Evidence for estrogenic contamination of the MAPK inhibitor PD98059.

  Endocrinology 20011201

• Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation.

  Journal of hypertension 20011201

• Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases.

  Biochemical pharmacology 20011201

• 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells.

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20011201

• Tissue inhibitor of metalloproteinases 1 and 2 directly stimulate the bone-resorbing activity of isolated mature osteoclasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011201

• Differential signaling for MCP-1-dependent integrin activation and chemotaxis.

  Annals of the New York Academy of Sciences 20011201

• Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alpha.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011201

• Regulation of aromatase activity in bone-derived cells: possible role of mitogen-activated protein kinase.

  The Journal of steroid biochemistry and molecular biology 20011201

• Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells.

  The Journal of biological chemistry 20011130

• Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter.

  The Journal of biological chemistry 20011130

• Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides.

  The Journal of biological chemistry 20011130

• Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.

  The Journal of biological chemistry 20011130

• Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20011130

• Involvement of MAP kinase cascades in Smad7 transcriptional regulation.

  Biochemical and biophysical research communications 20011130

• Divers pathways mediate delta-opioid receptor down regulation within the same cell.

  Brain research. Molecular brain research 20011130

• Enhancement of epidermal growth factor signaling and activation of SRC kinase by gangliosides.

  The Journal of biological chemistry 20011116

• Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin.

  The Journal of biological chemistry 20011116

• Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.

  The Biochemical journal 20011115

• Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated toxicity by U0126 an ERK1/2 and p38 kinase inhibitor.

  Biochemical pharmacology 20011115

• Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions.

  The Journal of biological chemistry 20011109

• Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.

  Biochemical and biophysical research communications 20011109

• A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells.

  FEBS letters 20011109

• N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity.

  The Journal of biological chemistry 20011102

• Epidermal growth factor down-regulates connexin-43 expression in cultured rat cortical astrocytes.

  Neuroscience letters 20011102

• TNF-alpha enhances intracellular glucocorticoid availability.

  FEBS letters 20011102

• Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs.

  Endocrinology 20011101

• PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway.

  Endocrinology 20011101

• Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Activation of beta(2)-adrenoceptor prevents shiga toxin 2-induced TNF-alpha gene transcription.

  Journal of the American Society of Nephrology : JASN 20011101

• PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.

  British journal of pharmacology 20011101

• Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20011101

• Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures.

  Journal of neurochemistry 20011101

• Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.

  British journal of pharmacology 20011101

• Angiotensin II via activation of type 1 receptor upregulates expression of endoglin in human coronary artery endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20011101

• Differential role of kinases in brain stem of hypertensive and normotensive rats.

  Hypertension (Dallas, Tex. : 1979) 20011101

• TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion.

  Journal of cell science 20011101

• Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells.

  British journal of cancer 20011101

• The zona pellucida-induced acrosome reaction of human spermatozoa involves extracellular signal-regulated kinase activation.

  Andrologia 20011101

• p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not.

  Free radical research 20011101

• Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.

  Neoplasia (New York, N.Y.) 20011101

• Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.

  Journal of neuro-oncology 20011101

• UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.

  The Journal of biological chemistry 20011026

• Antioxidants N-acetylcysteine (NAC) and 2-mercaptoethanol (2-ME) affect the survival and differentiative potential of cholinergic precursors from the embryonic septal nuclei and basal forebrain: involvement of ras signaling.

  Brain research. Developmental brain research 20011024

• Erythropoietin activates two distinct signaling pathways required for the initiation and the elongation of c-myc.

  The Journal of biological chemistry 20011019

• Platelet-derived growth factor inhibits smooth muscle cell adhesion to fibronectin by ERK-dependent and ERK-independent pathways.

  The Journal of biological chemistry 20011019

• Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.

  Toxicology 20011015

• Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line.

  The Biochemical journal 20011015

• Quercetin abrogates taxol-mediated signaling by inhibiting multiple kinases.

  Experimental cell research 20011015

• Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation.

  Oncogene 20011011

• sPLA(2) cooperates with cPLA(2)alpha to regulate prostacyclin synthesis in human endothelial cells.

  Biochemical and biophysical research communications 20011005

• Rapid activation of ERK1/2 mitogen-activated protein kinase by corticosterone in PC12 cells.

  Biochemical and biophysical research communications 20011005

• Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.

  American journal of physiology. Cell physiology 20011001

• Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20011001

• Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.

  The Journal of pharmacology and experimental therapeutics 20011001

• Dipyridamole inhibits TGF-beta-induced collagen gene expression in human peritoneal mesothelial cells.

  Kidney international 20011001

• NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.

  Cellular microbiology 20011001

• Hepatocyte growth factor protects cardiac myocytes against oxidative stress-induced apoptosis.

  Free radical biology & medicine 20011001

• In vivo intracellular signaling as a marker of antiangiogenic activity.

  Cancer research 20011001

• Phosphatidylinositol 3-kinase and ERK are required for NF-kappaB activation but not for phagocytosis.

  Journal of leukocyte biology 20011001

• Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage.

  Osteoarthritis and cartilage 20011001

• p73 is a growth-regulated protein in vascular smooth muscle cells and is present at high levels in human atherosclerotic plaque.

  Cellular signalling 20011001

• Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity.

  Journal of molecular and cellular cardiology 20011001

• Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.

  British journal of pharmacology 20011001

• Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ.

  Journal of neurochemistry 20011001

• Expression of cyclooxygenase-2 in human neutrophils activated by Helicobacter pylori water-soluble proteins: possible involvement of NF-kappaB and MAP kinase signaling pathway.

  Digestive diseases and sciences 20011001

• Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.

  Journal of cell science 20011001

• Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study.

  The European journal of neuroscience 20011001

• Regulation of Ras and Rho small G proteins by SHP-2.

  Genes to cells : devoted to molecular & cellular mechanisms 20011001

• Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.

  Journal of gastroenterology and hepatology 20011001

• Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts.

  The British journal of dermatology 20011001

• Cross-talk between signalling pathways and the multidrug resistant protein MDR-1.

  British journal of cancer 20011001

• Simultaneous signalling through c-mpl, c-kit and CXCR4 enhances the proliferation and differentiation of human megakaryocyte progenitors: possible roles of the PI3-K, PKC and MAPK pathways.

  British journal of haematology 20011001

• Ras/MAP kinase pathway is associated with the control of myotube formation but not myofibril assembly in quail myoblasts transformed with Rous sarcoma virus.

  Cell structure and function 20011001

• Expression of human cystatin A by keratinocytes is positively regulated via the Ras/MEKK1/MKK7/JNK signal transduction pathway but negatively regulated via the Ras/Raf-1/MEK1/ERK pathway.

  The Journal of biological chemistry 20010928

• Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins.

  Brain research. Developmental brain research 20010923

• Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.

  The Journal of biological chemistry 20010921

• Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity.

  Journal of immunology (Baltimore, Md. : 1950) 20010915

• Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.

  The Journal of clinical investigation 20010915

• Smooth muscle cell response to mechanical injury involves intracellular calcium release and ERK1/ERK2 phosphorylation.

  Experimental cell research 20010910

• PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways.

  Biochemical and biophysical research communications 20010907

• MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells.

  Biochemical and biophysical research communications 20010907

• Activation of p44/p42 mitogen-activated protein kinase limits triiodothyronine-stimulated alkaline phosphatase activity in osteoblasts.

  Biochemical and biophysical research communications 20010907

• R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.

  Biochemical and biophysical research communications 20010907

• Tumour necrosis factor-alpha enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells.

  Cellular signalling 20010901

• cAMP potentiates H(2)O(2)-induced ERK1/2 phosphorylation without the requirement for MEK1/2 phosphorylation.

  Cellular signalling 20010901

• LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes.

  Endocrinology 20010901

• Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells.

  Journal of the American Society of Nephrology : JASN 20010901

• Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.

  Blood 20010901

• Mechanism of action of angiotensin II in human isolated subcutaneous resistance arteries.

  British journal of pharmacology 20010901

• Regulation of interleukin-8 gene expression after phagocytosis of zymosan by human monocytic cells.

  Journal of leukocyte biology 20010901

• Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.

  Carcinogenesis 20010901

• Role of calcineurin in insulin-like growth factor-1-induced hypertrophy of cultured adult rat ventricular myocytes.

  Japanese circulation journal 20010901

• Cyclic AMP modulates the response of central nervous system glia to fibroblast growth factor-2 by redirecting signalling pathways.

  Journal of neurochemistry 20010901

• Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation.

  Hypertension (Dallas, Tex. : 1979) 20010901

• Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate.

  Molecular carcinogenesis 20010901

• Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells.

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20010901

• Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.

  The European journal of neuroscience 20010901

• Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors.

  Journal of cell science 20010901

• Stimulatory effect of zinc on deoxyribonucleic acid synthesis in bone growth of newborn rats: enhancement with zinc and insulin-like growth factor-I.

  Calcified tissue international 20010901

• Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20010831

• Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway.

  The Journal of biological chemistry 20010831

• Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

  The Journal of biological chemistry 20010831

• Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cells.

  Biochemical and biophysical research communications 20010831

• Ca2+ -dependent activation of tyrosine hydroxylase involves MEK1.

  Neuroreport 20010828

• Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation.

  The Journal of biological chemistry 20010824

• The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth.

  The Journal of biological chemistry 20010824

• Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815

• Requirement for tyrosine kinase-ERK1/2 signaling in alpha 1 beta 1 integrin-mediated collagen matrix remodeling by rat mesangial cells.

  Experimental cell research 20010815

• Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by 'MEK-specific' inhibitors PD 098059 and U0126 in differentiating HL60 cells.

  Experimental cell research 20010815

• Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.

  Journal of immunology (Baltimore, Md. : 1950) 20010815

• Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.

  American journal of respiratory and critical care medicine 20010815

• Nuclear translocation of extracellular signal-regulated kinases in neuronal excitotoxicity.

  Neuroreport 20010808

• Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.

  Circulation 20010807

• A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology.

  The Journal of biological chemistry 20010803

• Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.

  The Journal of biological chemistry 20010803

• Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway.

  The Journal of biological chemistry 20010803

• Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.

  Circulation research 20010803

• p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils.

  FEBS letters 20010803

• Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.

  American journal of physiology. Lung cellular and molecular physiology 20010801

• HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing.

  Experimental eye research 20010801

• Insulin-independent, MAPK-dependent stimulation of NKCC activity in skeletal muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010801

• Activation of Akt1 by human 5-hydroxytryptamine (serotonin)1B receptors is sensitive to inhibitors of MEK.

  The Journal of pharmacology and experimental therapeutics 20010801

• Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells.

  Molecular pharmacology 20010801

• Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression.

  The Biochemical journal 20010801

• Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells.

  Kidney international 20010801

• Mechanism of prostaglandin D(2)-stimulated heat shock protein 27 induction in osteoblasts.

  Cellular signalling 20010801

• Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

  Journal of neurochemistry 20010801

• Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation.

  Journal of neurochemistry 20010801

• Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture.

  Journal of neurochemistry 20010801

• Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.

  Journal of neurochemistry 20010801

• Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.

  Journal of neurochemistry 20010801

• Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

  Nature cell biology 20010801

• Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production.

  British journal of pharmacology 20010801

• Hepatocyte growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.

  European journal of biochemistry 20010801

• Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK.

  The Journal of clinical endocrinology and metabolism 20010801

• Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.

  Pflugers Archiv : European journal of physiology 20010801

• Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells.

  Biological chemistry 20010801

• Arylhydrocarbon receptor (AhR) is involved in negative regulation of adipose differentiation in 3T3-L1 cells: AhR inhibits adipose differentiation independently of dioxin.

  Journal of cell science 20010801

• Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells.

  Differentiation; research in biological diversity 20010801

• Activation of p42/44 mitogen-activated protein kinase pathway in long-term potentiation induced by nicotine in hippocampal CA1 region in rats.

  Acta pharmacologica Sinica 20010801

• Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.

  Circulation 20010731

• Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements.

  The Journal of biological chemistry 20010727

• Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway.

  FEBS letters 20010727

• Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells.

  Neuroreport 20010720

• Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells.

  Biochemical and biophysical research communications 20010720

• G-protein-coupled-receptor activation of the smooth muscle calponin gene.

  The Biochemical journal 20010715

• Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.

  Cancer research 20010715

• Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35).

  Brain research 20010713

• PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.

  Biochemical and biophysical research communications 20010713

• The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src.

  Biochemical and biophysical research communications 20010713

• Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.

  The Journal of biological chemistry 20010706

• Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells.

  American journal of physiology. Cell physiology 20010701

• Regulation of ERK phosphorylation in differentiated arterial muscle of rabbits.

  American journal of physiology. Heart and circulatory physiology 20010701

• Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase.

  Archives of biochemistry and biophysics 20010701

• Epidermal growth factor regulation of equine glycoprotein hormone alpha subunit expression in trophoblast cells.

  Biology of reproduction 20010701

• Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.

  Diabetes 20010701

• Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

  Cancer research 20010701

• c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.

  The Journal of clinical investigation 20010701

• Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans.

  Journal of leukocyte biology 20010701

• Differential regulation of redox responsive transcription factors by the nephrocarcinogen 2,3,5-Tris(glutathion-S-yl)hydroquinone.

  Chemical research in toxicology 20010701

• Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein.

  British journal of pharmacology 20010701

• Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells.

  Cell and tissue research 20010701

• Endothelin-1 increases glucose transporter glut1 mRNA accumulation in 3T3-L1 adipocytes by a mitogen-activated protein kinase-dependent pathway.

  Cellular signalling 20010701

• Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes.

  Molecular and cellular biochemistry 20010701

• Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1.

  The Journal of biological chemistry 20010629

• Novel role for JNK as a stress-activated Bcl2 kinase.

  The Journal of biological chemistry 20010629

• Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

  The Journal of biological chemistry 20010629

• IL-6 upregulates its own receptor on some human myeloma cell lines.

  Cytokine 20010621

• Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

  The Journal of biological chemistry 20010615

• Rac1 activity is required for the activation of hypoxia-inducible factor 1.

  The Journal of biological chemistry 20010615

• Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering.

  The Journal of biological chemistry 20010615

• Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation.

  The Journal of biological chemistry 20010615

• Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): roles of mitogen-activated protein kinase and interleukin-1beta.

  Biochemical pharmacology 20010615

• Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins.

  Free radical biology & medicine 20010615

• The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.

  Oncogene 20010614

• Regulation of the levels of small heat-shock proteins during differentiation of C2C12 cells.

  Experimental cell research 20010610

• Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.

  Brain research 20010608

• c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.

  Oncogene 20010607

• Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway.

  The Journal of biological chemistry 20010601

• Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.

  The Journal of biological chemistry 20010601

• Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor.

  American journal of physiology. Renal physiology 20010601

• Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.

  Toxicological sciences : an official journal of the Society of Toxicology 20010601

• A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication.

  Nature neuroscience 20010601

• Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway.

  The Journal of clinical endocrinology and metabolism 20010601

• Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010601

• Persistent versus transient map kinase (ERK) activation in the proliferation of lung epithelial type 2 cells.

  Experimental lung research 20010601

• Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.

  Journal of hypertension 20010601

• Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010601

• TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.

  Leukemia 20010601

• Propofol inhibits FMLP-stimulated phosphorylation of p42 mitogen-activated protein kinase and chemotaxis in human neutrophils.

  British journal of anaesthesia 20010601

• Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo.

  Molecular and cellular biochemistry 20010601

• Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways.

  Oncogene 20010531

• Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells: a mechanism for cell adhesion.

  Biochemical and biophysical research communications 20010525

• Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

  European journal of pharmacology 20010525

• Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells.

  The Journal of biological chemistry 20010518

• Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death.

  Brain research 20010518

• Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.

  European journal of pharmacology 20010518

• Vascular endothelial growth factor increases Rana vascular permeability and compliance by different signalling pathways.

  The Journal of physiology 20010515

• The Ras radiation resistance pathway.

  Cancer research 20010515

• Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis.

  The Journal of biological chemistry 20010511

• MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors.

  The Journal of biological chemistry 20010511

• 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange.

  The Journal of biological chemistry 20010511

• Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.

  The Journal of biological chemistry 20010511

• ERK mediates effects of glycated albumin in mesangial cells.

  Biochemical and biophysical research communications 20010511

• Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition.

  The Journal of biological chemistry 20010504

• Mechanisms of P2 receptor-evoked DNA synthesis in thyroid FRTL-5 cells.

  Journal of cellular physiology 20010501

• Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK.

  Toxicological sciences : an official journal of the Society of Toxicology 20010501

• Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha.

  Molecular pharmacology 20010501

• How protein kinase C activation protects nerve cells from oxidative stress-induced cell death.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010501

• Endotoxin (LPS) stimulates 4E-BP1/PHAS-I phosphorylation in macrophages.

  The Journal of surgical research 20010501

• Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.

  The Journal of surgical research 20010501

• ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

  Nature cell biology 20010501

• Expression of a novel RNA-splicing factor, RA301/Tra2beta, in vascular lesions and its role in smooth muscle cell proliferation.

  The American journal of pathology 20010501

• Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20010501

• Lysophosphatidylcholine induces early growth response factor-1 expression and activates the core promoter of PDGF-A chain in vascular endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20010501

• Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression.

  Arteriosclerosis, thrombosis, and vascular biology 20010501

• Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease.

  Journal of neurochemistry 20010501

• Tumor necrosis factor-alpha is induced through phorbol ester--and glycated human albumin-dependent pathway in THP-1 cells.

  Cellular signalling 20010501

• Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.

  Cellular signalling 20010501

• Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.

  Experimental hematology 20010501

• Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function.

  Experimental hematology 20010501

• Immunostimulation by the synthetic lipopeptide P3CSK4: TLR4-independent activation of the ERK1/2 signal transduction pathway in macrophages.

  Immunology 20010501

• Activation of multiple MAPK pathways (ERKs, JNKs, p38-MAPK) by diverse stimuli in the amphibian heart.

  Molecular and cellular biochemistry 20010501

• Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.

  Glycoconjugate journal 20010501

• Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival.

  Biochimica et biophysica acta 20010430

• The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis.

  The Journal of biological chemistry 20010427

• Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.

  The Journal of biological chemistry 20010427

• The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages.

  The Journal of biological chemistry 20010427

• Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway.

  The Journal of biological chemistry 20010427

• Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.

  The Journal of biological chemistry 20010427

• A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha.

  Biochemical and biophysical research communications 20010427

• Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-kappa B pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.

  The Journal of biological chemistry 20010420

• MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28.

  The Journal of biological chemistry 20010420

• Expression of 74-kDa histidine decarboxylase protein in a macrophage-like cell line RAW 264.7 and inhibition by dexamethasone.

  European journal of pharmacology 20010420

• Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells.

  Brain research. Molecular brain research 20010418

• Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.

  Brain research. Molecular brain research 20010418

• p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades.

  The EMBO journal 20010417

• A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells.

  Experimental cell research 20010415

• Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A(2).

  Blood 20010415

• Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis.

  The Journal of biological chemistry 20010413

• Thrombomodulin prolongs thrombin-induced extracellular signal-regulated kinase phosphorylation and nuclear retention in endothelial cells.

  Circulation research 20010413

• Signaling pathways activated by alpha1-adrenergic receptor subtypes in PC12 cells.

  Life sciences 20010406

• Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody.

  Oncogene 20010405

• IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010401

• Human uterine myometrial smooth muscle cell proliferation and vascular endothelial growth-factor production in response to platelet-derived growth factor.

  The Journal of endocrinology 20010401

• The role of mitogen-activated protein kinase activation within focal adhesions in chemotaxis toward FGF-2 by murine brain capillary endothelial cells.

  Experimental cell research 20010401

• Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion.

  Blood 20010401

• Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.

  Blood 20010401

• Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.

  British journal of pharmacology 20010401

• Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3',5'-monophosphate effects on prolactin promoter activity.

  Molecular endocrinology (Baltimore, Md.) 20010401

• Inhibition of protein phosphatase PP1 in GH3B6, but not in GH3 cells, activates the MEK/ERK/c-fos pathway and the human prolactin promoter, involving the coactivator CPB/p300.

  Molecular endocrinology (Baltimore, Md.) 20010401

• MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes.

  Journal of molecular and cellular cardiology 20010401

• Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.

  The Journal of physiology 20010401

• Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.

  British journal of cancer 20010401

• NMDA-induced phosphorylation of the microtubule-associated protein MAP-2 is mediated by activation of nitric oxide synthase and MAP kinase.

  The European journal of neuroscience 20010401

• Modulation of CREB and NF-kappaB signal transduction by cannabinol in activated thymocytes.

  Cellular signalling 20010401

• Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.

  Cellular signalling 20010401

• Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells.

  American journal of respiratory cell and molecular biology 20010401

• Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos.

  American journal of respiratory cell and molecular biology 20010401

• 4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial cells.

  American journal of respiratory cell and molecular biology 20010401

• Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.

  Journal of leukocyte biology 20010401

• Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.

  Inflammation 20010401

• Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.

  Glycobiology 20010401

• Grb-2-associated binder-1 is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3'-kinase binding site.

  DNA and cell biology 20010401

• Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.

  The Journal of biological chemistry 20010330

• CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.

  The Journal of biological chemistry 20010330

• Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid.

  The Journal of biological chemistry 20010330

• Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes.

  The Journal of biological chemistry 20010330

• The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells.

  Journal of cellular biochemistry 20010326

• Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia.

  The Journal of biological chemistry 20010323

• Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.

  The Journal of biological chemistry 20010323

• A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers.

  Journal of immunology (Baltimore, Md. : 1950) 20010315

• Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase.

  Journal of neuroscience research 20010315

• Opposite regulation of the HPV 20-URR and HPV 27-URR promoters by ultraviolet irradiation and cytokines.

  International journal of cancer 20010315

• Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.

  The Journal of biological chemistry 20010309

• Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.

  The Journal of biological chemistry 20010309

• Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth.

  The Journal of biological chemistry 20010309

• Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.

  The Journal of biological chemistry 20010309

• T cell activation signals upregulate CBP-dependent transcriptional activity.

  Biochemical and biophysical research communications 20010309

• Glycated serum albumin-induced vascular smooth muscle cell proliferation through activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by protein kinase C.

  Biochemical and biophysical research communications 20010309

• Synergistic activation of RSK correlates with c-fos induction in MO7e cells stimulated with GM-CSF plus Steel factor.

  Biochemical and biophysical research communications 20010309

• Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.

  Oncogene 20010308

• Functional significance of hemodynamic overload-induced expression of leukemia-inhibitory factor in the adult mammalian heart.

  Circulation 20010306

• Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts.

  The Journal of biological chemistry 20010302

• CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation.

  Brain research 20010302

• Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.

  Journal of cellular physiology 20010301

• Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.

  Molecular pharmacology 20010301

• Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.

  International journal of molecular medicine 20010301

• Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.

  International journal of molecular medicine 20010301

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  Endocrinology 20010301

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  Endocrinology 20010301

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  The Journal of pharmacology and experimental therapeutics 20010301

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  Biology of reproduction 20010301

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  Journal of immunology (Baltimore, Md. : 1950) 20010301

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  Nature cell biology 20010301

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  Arteriosclerosis, thrombosis, and vascular biology 20010301

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  The American journal of pathology 20010301

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  Journal of neurochemistry 20010301

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  Biochemical and biophysical research communications 20010301

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  Hypertension (Dallas, Tex. : 1979) 20010301

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  British journal of haematology 20010301

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  Molecular and cellular neurosciences 20010301

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  European journal of cell biology 20010301

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  Journal of hypertension 20010301

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  International immunopharmacology 20010301

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  Circulation research 20010216

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  European journal of pharmacology 20010216

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  Journal of immunology (Baltimore, Md. : 1950) 20010215

• Heparin-binding epidermal-growth-factor-like growth factor gene expression is induced by scrape-wounding epithelial cell monolayers: involvement of mitogen-activated protein kinase cascades.

  The Biochemical journal 20010215

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  The Biochemical journal 20010215

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  Cancer research 20010215

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  Cancer research 20010215

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  Biochemical and biophysical research communications 20010209

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  The Journal of biological chemistry 20010202

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201

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  American journal of physiology. Heart and circulatory physiology 20010201

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  American journal of respiratory cell and molecular biology 20010201

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  American journal of respiratory cell and molecular biology 20010201

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  Endocrinology 20010201

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  Experimental hematology 20010201

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  European journal of biochemistry 20010201

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  Hypertension (Dallas, Tex. : 1979) 20010201

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  Hypertension (Dallas, Tex. : 1979) 20010201

• Phenotypic modulation of arterial smooth muscle cells is associated with prolonged activation of ERK1/2.

  Differentiation; research in biological diversity 20010201

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  Journal of biomolecular screening 20010201

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  The Biochemical journal 20010115

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  Journal of immunology (Baltimore, Md. : 1950) 20010115

• p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

  EMBO reports 20010115

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  Oncogene 20010111

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  European journal of pharmacology 20010105

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

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  American journal of physiology. Gastrointestinal and liver physiology 20010101

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  Endocrinology 20010101

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  Endocrinology 20010101

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

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  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010101

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  Carcinogenesis 20010101

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  Journal of cellular biochemistry 20010101

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  Naunyn-Schmiedeberg's archives of pharmacology 20010101

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  Diabetologia 20010101

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  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010101

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  Journal of cellular biochemistry 20010101

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  Journal of biomedical science 20010101

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  Anticancer research 20010101

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  Anticancer research 20010101

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  Neuroscience 20010101

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  Advances in enzyme regulation 20010101

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  Cell biology international 20010101

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  Journal of vascular research 20010101

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  Journal of cellular biochemistry 20010101

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  Cell stress & chaperones 20010101

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  Amino acids 20010101

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  In vitro & molecular toxicology 20010101

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  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20010101

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  International journal of pancreatology : official journal of the International Association of Pancreatology 20010101

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  International journal of experimental diabetes research 20010101

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  The Journal of biological chemistry 20001215

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  Blood 20001215

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  British journal of pharmacology 20001201

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  Neurotoxicology 20001201

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  The Journal of biological chemistry 20001013

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  Kidney international 20000901

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  Journal of molecular and cellular cardiology 20000801

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  Carcinogenesis 20000801

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  The Journal of pharmacology and experimental therapeutics 20000701

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  European cytokine network 20000601

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  Journal of cardiovascular pharmacology 20000501

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  The Journal of biological chemistry 20000414

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  The Biochemical journal 20000401

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  Blood 20000401

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  Nature medicine 20000301

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  American journal of physiology. Cell physiology 20000301

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  Oncogene 20000203

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  Journal of immunology (Baltimore, Md. : 1950) 20000201

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  Journal of hepatology 20000201

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  American journal of physiology. Lung cellular and molecular physiology 20000101

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  The Anatomical record 19991215

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  The American journal of physiology 19991101

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  Kidney international 19990901

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  Biochimica et biophysica acta 19990812

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  FEBS letters 19981211

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  Toxicology letters 19980316

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  The Journal of biological chemistry 19980123

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