16858-02-9 | Tpen

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$7.00	$5.00
10mg	≥95%	in stock	$22.00	$16.00
50mg	97%	in stock	$39.00	$27.00
250mg	95%	in stock	$105.00	$73.00
1g	>97.0%(T)	in stock	$229.00	$160.00
5g	>97.0%(T)	in stock	$774.00	$542.00

Description

• Catalog Number: AA90716
• Chemical Name: Tpen
• CAS Number: 16858-02-9
• Molecular Formula: C26H28N6
• Molecular Weight: 424.5407
• MDL Number: MFCD00036918
• SMILES: c1ccc(nc1)CN(Cc1ccccn1)CCN(Cc1ccccn1)Cc1ccccn1

Computed Properties

• Complexity: 419
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• XLogP3: 2.1

Literature

• Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca(v)3.2 in mice.

  Toxicology 20180115

• Oxidative stress and endocytosis are involved in upregulation of interleukin-8 expression in airway cells exposed to PM2.5.

  Environmental toxicology 20161201

• Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake.

  Metallomics : integrated biometal science 20141101

• Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.

  Toxicology and applied pharmacology 20140115

• Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells.

  Investigative ophthalmology & visual science 20120809

• Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3.

  The Journal of nutritional biochemistry 20120801

• Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.

  Biology of reproduction 20120701

• Zinc enhances adiponectin oligomerization to octadecamers but decreases the rate of disulfide bond formation.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120401

• Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine.

  Inorganic chemistry 20120319

• Colorimetric and fluorescent signaling of Au3+ by desulfurization of thiocoumarin.

  Inorganic chemistry 20120305

• Zinc balance is critical for NFI-C mediated regulation of odontoblast differentiation.

  Journal of cellular biochemistry 20120301

• Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells.

  Biochimica et biophysica acta 20120201

• Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo.

  Journal of neurophysiology 20120201

• Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice.

  Endocrinology 20120201

• Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways.

  Nutritional neuroscience 20120101

• Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.

  PloS one 20120101

• Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations.

  PloS one 20120101

• Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure.

  PloS one 20120101

• Hyperforin changes the zinc-storage capacities of brain cells.

  Neuropharmacology 20111201

• Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia.

  Glia 20111201

• Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain.

  Brain research 20111018

• A zinc chelator TPEN attenuates airway hyperresponsiveness and airway inflammation in mice in vivo.

  Allergology international : official journal of the Japanese Society of Allergology 20110901

• Exposure to an environmental neurotoxicant hastens the onset of amyotrophic lateral sclerosis-like phenotype in human Cu2+/Zn2+ superoxide dismutase 1 G93A mice: glutamate-mediated excitotoxicity.

  The Journal of pharmacology and experimental therapeutics 20110801

• Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons.

  The European journal of neuroscience 20110701

• NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.

  Antioxidants & redox signaling 20110615

• Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.

  Neurobiology of disease 20110601

• A role for zinc in regulating hypoxia-induced contractile events in pulmonary endothelium.

  American journal of physiology. Lung cellular and molecular physiology 20110601

• LPS-induced decrease in intracellular labile zinc, [Zn]i, contributes to apoptosis in cultured sheep pulmonary artery endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20110401

• Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.

  Journal of neurochemistry 20110401

• Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.

  Biology of reproduction 20110301

• Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.

  Nutritional neuroscience 20110301

• Influence of zinc and zinc chelator on HT-29 colorectal cell line.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110201

• Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice.

  Toxicology letters 20110115

• MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy.

  Oncogene 20110106

• MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.

  PloS one 20110101

• HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung.

  AIDS research and therapy 20110101

• Fetal bovine serum requirement for pyrrolidine dithiocarbamate-induced apoptotic cell death of MCF-7 breast tumor cells.

  European journal of pharmacology 20101215

• Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201

• Complex role of zinc in methamphetamine toxicity in vitro.

  Neuroscience 20101124

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Acidosis-induced zinc-dependent death of cultured cerebellar granule neurons.

  Cellular and molecular neurobiology 20100801

• Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release.

  Development (Cambridge, England) 20100801

• The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury.

  Journal of molecular and cellular cardiology 20100701

• Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands.

  American journal of physiology. Gastrointestinal and liver physiology 20100701

• Levels of semenogelin in human spermatozoa decrease during capacitation: involvement of reactive oxygen species and zinc.

  Human reproduction (Oxford, England) 20100701

• The thiol-modifying agent N-ethylmaleimide elevates the cytosolic concentration of free Zn(2+) but not of Ca(2+) in murine cortical neurons.

  Cell calcium 20100701

• Cadmium inhibits acid secretion in stimulated frog gastric mucosa.

  Toxicology and applied pharmacology 20100601

• [Progress in the study of HIV-1 Vif and related inhibitors].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100601

• Effects of zinc ex vivo and intracellular zinc chelator in vivo on taurine uptake in goldfish retina.

  Amino acids 20100501

• Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.

  Journal of leukocyte biology 20100501

• Zinc signals promote IL-2-dependent proliferation of T cells.

  European journal of immunology 20100501

• The zinc-dependent protease activity of the botulinum neurotoxins.

  Toxins 20100501

• Nitric oxide synthase activation and oxidative stress, but not intracellular zinc dyshomeostasis, regulate ultraviolet B light-induced apoptosis.

  Life sciences 20100313

• Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.

  Bone 20100301

• Effects of postconditioning with N,N,N'N'-tetrakis-[2-pyridylmethyl]-ethylenediamine in isolated rat hearts.

  Korean journal of anesthesiology 20100301

• Endogenous zinc mediates apoptotic programmed cell death in the developing brain.

  Neurotoxicity research 20100201

• Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20100201

• Validation of TPEN as a zinc chelator in fluorescence probing of calcium in cells with the indicator Fura-2.

  Journal of fluorescence 20100101

• The Zur regulon of Corynebacterium glutamicum ATCC 13032.

  BMC genomics 20100101

• Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators.

  Virology journal 20100101

• Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons.

  Journal of molecular signaling 20100101

• Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light.

  Molecular vision 20100101

• Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.

  PloS one 20100101

• Methylmercury elicits intracellular Zn2+ release in rat thymocytes: its relation to methylmercury-induced decrease in cellular thiol content.

  Toxicology letters 20091215

• Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity.

  Toxicology in vitro : an international journal published in association with BIBRA 20091201

• The selective quantification of iron by hexadentate fluorescent probes.

  Bioorganic & medicinal chemistry 20091201

• Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach.

  Molecular cancer therapeutics 20091101

• Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha.

  Hepatology (Baltimore, Md.) 20091001

• Increase in intracellular Zn2+ concentration by thimerosal in rat thymocytes: intracellular Zn2+ release induced by oxidative stress.

  Toxicology in vitro : an international journal published in association with BIBRA 20090901

• Rising zinc: a significant cause of ischemic neuronal death in the CA1 region of rat hippocampus.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090801

• Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20090701

• N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress.

  Journal of thrombosis and haemostasis : JTH 20090601

• Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.

  The Biochemical journal 20090513

• Essential role of p53 in TPEN-induced neuronal apoptosis.

  FEBS letters 20090506

• Theoretical study of cyclohexane hydroxylation by three possible isomers of [FeIV(O)(R-TPEN)] 2+: does the pentadentate ligand wrapping around the metal center differently lead to the different stability and reactivity?

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090501

• Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy.

  Epilepsia 20090401

• Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione.

  American journal of physiology. Cell physiology 20090401

• Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons.

  Neuroscience 20090303

• Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells.

  Toxicology and applied pharmacology 20090301

• Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• Light stimulation evokes two different calcium responses in Müller glial cells of the guinea pig retina.

  The European journal of neuroscience 20090301

• Detection of zinc translocation into apical dendrite of CA1 pyramidal neuron after electrical stimulation.

  Journal of neuroscience methods 20090215

• Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis.

  Biochimica et biophysica acta 20090201

• Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes.

  Cell calcium 20090201

• Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.

  European journal of immunology 20090201

• Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

• Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).

  Molecular and cellular biochemistry 20090101

• Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells.

  BMC neuroscience 20090101

• 'cAMP sponge': a buffer for cyclic adenosine 3', 5'-monophosphate.

  PloS one 20090101

• Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN.

  Cell calcium 20090101

• Mechanisms of Zn2+ efflux in cultured cortical neurons.

  Journal of neurochemistry 20081201

• Zinc-binding compounds induce cancer cell death via distinct modes of action.

  Cancer letters 20081128

• Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.

  Cell death and differentiation 20081101

• Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms.

  Brain research 20081027

• NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

  Cellular signalling 20081001

• Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling.

  Journal of the American College of Nutrition 20081001

• Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.

  Journal of the American Chemical Society 20080924

• Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway.

  The Prostate 20080915

• Isoquinoline-based TQEN family as TPEN-derived fluorescent zinc sensors.

  Inorganic chemistry 20080818

• Zn2+ influx is critical for some forms of spreading depression in brain slices.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080806

• HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis.

  American journal of respiratory cell and molecular biology 20080801

• The level of free intracellular zinc mediates programmed cell death/cell survival decisions in plant embryos.

  Plant physiology 20080701

• Nitric-oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone.

  Circulation research 20080620

• The involvement of caspase-11 in TPEN-induced apoptosis.

  FEBS letters 20080611

• Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.

  Nutritional neuroscience 20080601

• Cooperation of metallothionein and zinc transporters for regulating zinc homeostasis in human intestinal Caco-2 cells.

  Nutrition research (New York, N.Y.) 20080601

• HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein.

  Virology 20080525

• Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes.

  Journal of cellular biochemistry 20080501

• Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein.

  Investigative ophthalmology & visual science 20080401

• Zinc binding ligands and cellular zinc trafficking: apo-metallothionein, glutathione, TPEN, proteomic zinc, and Zn-Sp1.

  Journal of inorganic biochemistry 20080301

• Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.

  American journal of physiology. Cell physiology 20080301

• Antibacterial activity of pyrrolidine dithiocarbamate.

  FEMS microbiology letters 20080301

• Prevention of calcification with TPEN in pericardial bio-prosthetic heart valve material.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201

• Expectation from science/prevention of calcification with TPEN in pericardial bio-prosthetic heart valve material.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201

• High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.

  Cellular & molecular biology letters 20080101

• Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20080101

• Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5).

  Biological chemistry 20071201

• Prevention of calcification with TPEN in pericardial bioprosthetic heart valve material.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20071201

• Extraction behavior and separation of lanthanides with a diglycol amic acid derivative and a nitrogen-donor ligand.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20071201

• Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands.

  American journal of physiology. Cell physiology 20071101

• Zinc regulates the ability of Cdc25C to activate MPF/cdk1.

  Journal of cellular physiology 20071001

• Cellular Zn2+ chelators cause 'dying-back' neurite degeneration associated with energy impairment.

  Journal of neuroscience research 20071001

• On the use of fluorescent probes to distinguish Ca2+ from Zn2+ in models of excitotoxicity.

  Cell calcium 20070901

• Potentiation of acid-sensing ion channels by sulfhydryl compounds.

  American journal of physiology. Cell physiology 20070601

• Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator.

  Current eye research 20070601

• Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815.

  The Journal of biological chemistry 20070504

• Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.

  Cancer science 20070501

• Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells.

  Experimental biology and medicine (Maywood, N.J.) 20070501

• Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability.

  The Journal of biological chemistry 20070406

• Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators.

  Toxicon : official journal of the International Society on Toxinology 20070401

• Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells.

  European journal of pharmacology 20070214

• Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes.

  Cell calcium 20070201

• T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells.

  Nutrition (Burbank, Los Angeles County, Calif.) 20070201

• Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray.

  International journal of cancer 20070115

• Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide.

  American journal of physiology. Lung cellular and molecular physiology 20070101

• Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101

• The use of the zinc-fluorophore, Zinpyr-1, in the study of zinc homeostasis in Arabidopsis roots.

  The New phytologist 20070101

• Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.

  Molecular medicine (Cambridge, Mass.) 20070101

• Effect of TPEN on the calcium release of cultured C2C12 mouse myotubes.

  Journal of muscle research and cell motility 20070101

• Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells.

  Nutrition research and practice 20070101

• Zinc modulates cytokine-induced lung epithelial cell barrier permeability.

  American journal of physiology. Lung cellular and molecular physiology 20061201

• Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.

  The Journal of biological chemistry 20061110

• Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemoprevention.

  Free radical biology & medicine 20061015

• Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression.

  Carcinogenesis 20061001

• Apo-metallothionein emerging as a major player in the cellular activities of metallothionein.

  Experimental biology and medicine (Maywood, N.J.) 20061001

• Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes.

  Experimental biology and medicine (Maywood, N.J.) 20061001

• Inhibition of cyclooxygenase-2 expression by zinc-chelator in retinal ischemia.

  Vision research 20060901

• Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression.

  American journal of physiology. Cell physiology 20060901

• Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.

  Nature immunology 20060901

• Zinc is required for Fc epsilon RI-mediated mast cell activation.

  Journal of immunology (Baltimore, Md. : 1950) 20060715

• [Effect of zinc on mRNA expression of ZIP4 in Caco2 cells].

  Wei sheng yan jiu = Journal of hygiene research 20060701

• Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060621

• The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.

  Biochemical and biophysical research communications 20060519

• Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells.

  Analytical biochemistry 20060515

• Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes.

  The Journal of biological chemistry 20060407

• Selenium prevents diabetes-induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle.

  American journal of physiology. Heart and circulatory physiology 20060301

• Apoptosis may underlie the pathology of zinc-deficient skin.

  Immunology and cell biology 20060201

• Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model.

  Journal of pharmacological sciences 20060201

• Cytosolic labile zinc: a marker for apoptosis in the developing rat brain.

  The European journal of neuroscience 20060101

• Apoptotic neuronal changes enhanced by zinc chelator--TPEN in organotypic rat hippocampal cultures exposed to anoxia.

  Folia neuropathologica 20060101

• Effect of the zinc chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) on hippocampal mossy fiber calcium signals and on synaptic transmission.

  Biological research 20060101

• Neuritic outgrowth from goldfish retinal explants, interaction of taurine and zinc.

  Advances in experimental medicine and biology 20060101

• New example of a non-heme mononuclear iron(IV) oxo complex. Spectroscopic data and oxidation activity.

  Inorganic chemistry 20051212

• Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger.

  Molecular pharmacology 20051201

• Taurine and zinc modulate outgrowth from goldfish retinal explants.

  Neurochemical research 20051201

• Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons.

  Brain research 20051102

• Comparative sensitivity of rat cerebellar neurons to dysregulation of divalent cation homeostasis and cytotoxicity caused by methylmercury.

  Toxicology and applied pharmacology 20051101

• Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis.

  PLoS biology 20051001

• Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices.

  Journal of the American Chemical Society 20050727

• Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase.

  Molecular and cellular biochemistry 20050701

• ZINC-mediated gene expression offers protection against H2O2-induced cytotoxicity.

  Toxicology and applied pharmacology 20050615

• N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine improves myocardial protection against ischemia by modulation of intracellular Ca2+ homeostasis.

  The Journal of pharmacology and experimental therapeutics 20050601

• Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

  Biochemistry 20050510

• Simultaneous detection of [metal(II)-tpen]2+ as kinetically inert cationic complexes using pre-capillary derivatization electrophoresis: an application to biological samples.

  The Analyst 20050501

• Search of chemical scaffolds for novel antituberculosis agents.

  Journal of biomolecular screening 20050401

• Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050309

• Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-alpha in conditions of heavy metal ion deficiency.

  Investigative ophthalmology & visual science 20050301

• Tetrakis(2-quinolinylmethyl)ethylenediamine (TQEN) as a new fluorescent sensor for zinc.

  Dalton transactions (Cambridge, England : 2003) 20050207

• TPEN attenuates hepatic apoptotic ischemia/ reperfusion injury and remote early cardiac dysfunction.

  Apoptosis : an international journal on programmed cell death 20050101

• Expression of apoptosis-related proteins in model of anoxia in vitro.

  Folia neuropathologica 20050101

• Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20050101

• The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.

  The Journal of biological chemistry 20041203

• Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041124

• Measurement of presynaptic zinc changes in hippocampal mossy fibers.

  Brain research 20041105

• XAS characterization of end-on and side-on peroxoiron(III) complexes of the neutral pentadentate N-donor ligand N-methyl-N,N',N'-tris(2-pyridylmethyl)ethane-1,2-diamine.

  Dalton transactions (Cambridge, England : 2003) 20041021

• Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications.

  Journal of the American Chemical Society 20041006

• Fungal susceptibility to zinc deprivation.

  The Journal of laboratory and clinical medicine 20041001

• Actions of zinc at mature Golgi cell to granule cell synapses in cerebellum of rats and mice.

  Neuroscience letters 20040826

• Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.

  Biochemical pharmacology 20040815

• Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.

  The Journal of nutrition 20040701

• Hippocampal mossy fiber calcium transients are maintained during long-term potentiation and are inhibited by endogenous zinc.

  Brain research 20040409

• Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.

  American journal of respiratory cell and molecular biology 20040401

• Unliganded human mutant alpha 7 nicotinic receptors are modulated by Ca2+ and trace levels of Zn2+.

  Neuropharmacology 20040401

• Evaluation, using targeted aequorins, of the roles of the endoplasmic reticulum and its (Ca2++Mg2+)ATP-ases in the activation of store-operated Ca2+ channels in liver cells.

  Cell calcium 20040401

• Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels.

  Neuron 20040205

• Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway.

  Journal of neurophysiology 20040201

• Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells.

  Gastroenterology 20040101

• Depletion of endogenous zinc stores induces oxidative stress and cell death in human melanoma cells.

  Acta medica (Hradec Kralove) 20040101

• Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.

  Experimental cell research 20031210

• Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release.

  Proceedings of the National Academy of Sciences of the United States of America 20031125

• A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores.

  The Journal of biological chemistry 20031010

• Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.

  The Journal of biological chemistry 20031003

• Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.

  The Journal of nutrition 20031001

• Zinc chelators inhibit eotaxin, RANTES, and MCP-1 production in stimulated human airway epithelium and fibroblasts.

  American journal of physiology. Lung cellular and molecular physiology 20030901

• Hg2+ signaling in trout hepatoma (RTH-149) cells: involvement of Ca2+-induced Ca2+ release.

  Cell calcium 20030901

• Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.

  The Journal of nutrition 20030801

• N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits ligand binding to certain G protein-coupled receptors.

  European journal of pharmacology 20030801

• Zinc-induced changes in ionic currents of cardiomyocytes.

  Biological trace element research 20030701

• A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.

  Proceedings of the National Academy of Sciences of the United States of America 20030610

• Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.

  The Journal of biological chemistry 20030110

• N,N,N ',N '-Tetrakis(2-pyridylmethyl)ethylenediamine and its analogues as hypodentate ligands. Synthesis and characterization of the rhodium(III), ruthenium(II), and palladium(II) complexes.

  Inorganic chemistry 20021202

• Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.

  European journal of biochemistry 20021201

• Zinc is involved in the expression of a nuclear-encoded alternative oxidase gene in the yeast Hansenula anomala.

  Bioscience, biotechnology, and biochemistry 20021201

• Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria.

  The Journal of biological chemistry 20021129

• Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells.

  Biochemical and biophysical research communications 20021004

• In situ chelation of Ca(2+) in intracellular stores induces capacitative Ca(2+) entry in bovine adrenal chromaffin cells.

  Annals of the New York Academy of Sciences 20021001

• Role of Zn(2+) in oxidative stress caused by endotoxin challenge.

  European journal of pharmacology 20020920

• A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion.

  Journal of the American Chemical Society 20020911

• DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells.

  American journal of physiology. Cell physiology 20020801

• Time course and magnitude of the calcium release induced by bright light in salamander rods.

  The Journal of physiology 20020801

• Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity.

  Mediators of inflammation 20020601

• Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.

  The Journal of physiology 20020501

• NMDA receptor-mediated currents in rat cerebellar granule and unipolar brush cells.

  Journal of neurophysiology 20020401

• [Role of intracellular zinc in programmed cell death].

  Pathologie-biologie 20020401

• pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons.

  American journal of physiology. Cell physiology 20020201

• Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein.

  American journal of physiology. Lung cellular and molecular physiology 20020201

• L-type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure.

  Synapse (New York, N.Y.) 20020101

• Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons.

  Brain research. Developmental brain research 20011231

• Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes.

  Blood 20011215

• Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes.

  Apoptosis : an international journal on programmed cell death 20011201

• Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis.

  Journal of leukocyte biology 20011001

• Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR.

  Journal of the American Chemical Society 20010905

• Characteristics of a store-operated calcium-permeable channel: sarcoendoplasmic reticulum calcium pump function controls channel gating.

  The Journal of biological chemistry 20010810

• The role of zinc binding in the biological activity of botulinum toxin.

  The Journal of biological chemistry 20010720

• Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors.

  Biochemical pharmacology 20010701

• Role of zinc in pulmonary endothelial cell response to oxidative stress.

  American journal of physiology. Lung cellular and molecular physiology 20010701

• Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis.

  Science (New York, N.Y.) 20010629

• Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity.

  The Journal of biological chemistry 20010622

• Modulation of caspase-3 activity by zinc ions and by the cell redox state.

  Experimental cell research 20010610

• p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515

• Receptor-operated osteoclast calcium sensing.

  Endocrinology 20010501

• Enzymatic autocatalysis of botulinum A neurotoxin light chain.

  Journal of protein chemistry 20010401

• Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc.

  The Journal of pharmacology and experimental therapeutics 20010301

• Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu+2), iron (Fe+3) and zinc in the hippocampus.

  Brain research 20010216

• Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells.

  Investigative ophthalmology & visual science 20010201

• High-affinity zinc potentiation of inhibitory postsynaptic glycinergic currents in the zebrafish hindbrain.

  Journal of neurophysiology 20010201

• [Transition metals and nitric oxide production in human endothelial cells].

  Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 20010101

• 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors.

  Receptors & channels 20010101

• Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria- dependent pathways.

  The Journal of biological chemistry 20001215

• Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis.

  Journal of cell science 20000901

• Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha.

  The American journal of clinical nutrition 20000101