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Characterization of muscarinic receptor binding by the novel radioligand, [(3)H]imidafenacin, in the bladder and other tissues of rats.
Journal of pharmacological sciences 20160701
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Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females.
Expert opinion on drug metabolism & toxicology 20121101
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Characterization of bladder selectivity of antimuscarinic agents on the basis of in vivo drug-receptor binding.
International neurourology journal 20120901
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Excitatory effect of propiverine hydrochloride on urethral activity in rats.
International journal of urology : official journal of the Japanese Urological Association 20120601
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Neurogenic bladder.
Advances in urology 20120101
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Effect of imidafenacin on nocturia and sleep disorder in patients with overactive bladder.
Urologia internationalis 20120101
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[Investigation of pharmacokinetics of crushed imidafenacin 0.1-mg tablet after single oral administration in healthy men].
Hinyokika kiyo. Acta urologica Japonica 20111201
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Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB.
NeuroImage 20110901
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In vivo bladder selectivity of imidafenacin, a novel antimuscarinic agent, assessed by using an effectiveness index for bladder capacity in rats.
Naunyn-Schmiedeberg's archives of pharmacology 20110901
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Quantitative analysis of pseudopolymorphic transformation of imidafenacin by application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate.
The Journal of pharmacy and pharmacology 20110701
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Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction.
The Journal of urology 20110601
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Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.
The Journal of pharmacology and experimental therapeutics 20110201
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[Efficacy and safety of imidafenacin in female patients with urge and mixed urinary incontinence].
Hinyokika kiyo. Acta urologica Japonica 20110101
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Immediate effect on overactive bladder symptoms following administration of imidafenacin.
Urologia internationalis 20110101
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An overview of the clinical use of antimuscarinics in the treatment of overactive bladder.
Advances in urology 20110101
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The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents.
Advances in urology 20110101
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Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Group Trial (the LIST Study).
Advances in urology 20110101
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Application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate to the characterization of the polymorphism of imidafenacin.
The Journal of pharmacy and pharmacology 20101101
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Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography.
Life sciences 20100731
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The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology 20100101
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A randomized, double-blind, placebo- and propiverine-controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder.
International journal of urology : official journal of the Japanese Urological Association 20090501
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Comparison of the effect of anti-muscarinic agents on bladder activity, urinary ATP level, and autonomic nervous system in rats.
Biomedical research (Tokyo, Japan) 20090401
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Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection.
Drug metabolism and pharmacokinetics 20090101
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Response to 'Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection'.
Drug metabolism and pharmacokinetics 20090101
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Long-term safety, tolerability, and efficacy of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder.
International journal of urology : official journal of the Japanese Urological Association 20081001
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A randomized, double-blind, placebo-controlled phase II dose-finding study of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder.
International journal of urology : official journal of the Japanese Urological Association 20080901
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Validation and application of a 96-well format solid-phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of digoxin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615
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[Pharmacological and clinical profile of imidafenacin developed as a new therapeutic agent for overactive bladder].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080501
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Effect of itraconazole on the pharmacokinetics of imidafenacin in healthy subjects.
Journal of clinical pharmacology 20080301
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Absolute bioavailability of imidafenacin after oral administration to healthy subjects.
British journal of clinical pharmacology 20080201
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No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects.
Drug metabolism and pharmacokinetics 20080101
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Population pharmacokinetic analysis of a novel muscarinic receptor antagonist, imidafenacin, in healthy volunteers and overactive bladder patients.
Drug metabolism and pharmacokinetics 20080101
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Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC 20070901
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Absorption, metabolism, and excretion of [14C]imidafenacin, a new compound for treatment of overactive bladder, after oral administration to healthy male subjects.
Drug metabolism and disposition: the biological fate of chemicals 20070901
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Synthesis of the metabolites of 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide (KRP-197/ONO-8025).
Chemical & pharmaceutical bulletin 20070701
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Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
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Drug-drug interactions in the metabolism of imidafenacin: role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymes.
Xenobiotica; the fate of foreign compounds in biological systems 20070201
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Effects of imidafenacin (KRP-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland.
Arzneimittel-Forschung 20070101
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Pharmacological effects of imidafenacin (KRP-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats. Comparison of effects on urinary bladder capacity and contraction, salivary secretion and performance in the Morris water maze task.
Arzneimittel-Forschung 20070101
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Pharmacological effects of KRP-197 on the human isolated urinary bladder.
Urologia internationalis 20030101
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Biomimetic oxidation of 2-methylimidazole derivative with a chemical model system for cytochrome P-450.
Chemical & pharmaceutical bulletin 20020801
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Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional.
Autonomic & autacoid pharmacology 20020601
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Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents.
Bioorganic & medicinal chemistry 19990601
