172889-26-8 | Pp1

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$63.00	$45.00
5mg	95%	in stock	$155.00	$108.00
10mg	95%	in stock	$222.00	$155.00
25mg	95%	in stock	$246.00	$172.00
100mg	95%	in stock	$446.00	$312.00

Description

• Catalog Number: AD42342
• Chemical Name: Pp1
• CAS Number: 172889-26-8
• Molecular Formula: C16H19N5
• Molecular Weight: 281.3556
• MDL Number: MFCD01076570
• SMILES: Cc1ccc(cc1)c1nn(c2c1c(N)ncn2)C(C)(C)C

Computed Properties

• Complexity: 358
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.8

Literature

• Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

  Journal of medicinal chemistry 20160526

• A fluorescent reporter of ATP binding-competent receptor kinases.

  Bioorganic & medicinal chemistry letters 20120901

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Displacement assay for the detection of stabilizers of inactive kinase conformations.

  Journal of medicinal chemistry 20100114

• Kinetic mechanism and inhibitor characterization of WNK1 kinase.

  Biochemistry 20091103

• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

  Nature chemical biology 20081101

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets.

  Journal of medicinal chemistry 20070809

• Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.

  Bioorganic & medicinal chemistry 20070115

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.

  Molecular pharmacology 20030801

• The specificities of protein kinase inhibitors: an update.

  The Biochemical journal 20030401

• The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.

  The Journal of biological chemistry 20030214

• Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

  The Journal of biological chemistry 19960112