-
Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton.
Toxicology 20170815
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CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20160601
-
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
Nature neuroscience 20151001
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Synthesis and physico-chemical properties in aqueous medium of all possible isomeric bromo analogues of benzo-1H-triazole, potential inhibitors of protein kinases.
The journal of physical chemistry. B 20120621
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Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.
International journal of molecular medicine 20120601
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Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
Bioorganic & medicinal chemistry 20120401
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Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.
Science signaling 20120207
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A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology 20120115
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Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability.
Oncology reports 20120101
-
Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.
International journal of biological sciences 20120101
-
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.
Scientific reports 20120101
-
Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.
PloS one 20120101
-
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.
Nature chemical biology 20111201
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Multisite-directed inhibitors of protein kinase CK2: new challenges.
Molecular and cellular biochemistry 20111001
-
Design and synthesis of CK2 inhibitors.
Molecular and cellular biochemistry 20111001
-
Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines.
Molecular and cellular biochemistry 20111001
-
The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes.
Molecular and cellular biochemistry 20110901
-
The protein kinase CK2 inhibitor TBB mediates up-regulation of MEK3/6 and p38δ activities, down-regulation of ERK1/2 activity and induction of G1/S arrest in normal human epidermal autocrine proliferating keratinocytes.
Journal of dermatological science 20110801
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The cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells.
Molecular and cellular biochemistry 20110701
-
CK2 phosphorylates AP-2α and increases its transcriptional activity.
BMB reports 20110701
-
Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110601
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Brain-derived neurotrophic factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear factor kappa B-mediated pathway in rat hippocampus.
Brain pathology (Zurich, Switzerland) 20110301
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Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton.
Molecular and cellular biochemistry 20110301
-
CK2 inhibition induces apoptosis via the ER stress response.
Cellular signalling 20110101
-
A specific inhibitor of protein kinase CK2 delays gamma-H2Ax foci removal and reduces clonogenic survival of irradiated mammalian cells.
Radiation oncology (London, England) 20110101
-
CK2 is acting upstream of MEK3/6 as a part of the signal control of ERK1/2 and p38 MAPK during keratinocytes autocrine differentiation.
Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101
-
IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase 2.
PloS one 20110101
-
Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy.
PloS one 20110101
-
Bromophenols in marine algae and their bioactivities.
Marine drugs 20110101
-
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
Molecular cancer 20110101
-
CK2 phosphorylation of Schistosoma mansoni HMGB1 protein regulates its cellular traffic and secretion but not its DNA transactions.
PloS one 20110101
-
Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.
Scientific reports 20110101
-
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Neuron 20101209
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Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
Blood 20101007
-
Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription.
The international journal of biochemistry & cell biology 20101001
-
The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2/Ikaros signaling pathway.
Toxicology in vitro : an international journal published in association with BIBRA 20101001
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Relative role of halogen bonds and hydrophobic interactions in inhibition of human protein kinase CK2α by tetrabromobenzotriazole and some C5-substituted analogues.
The journal of physical chemistry. B 20100819
-
A medicinal chemist's guide to molecular interactions.
Journal of medicinal chemistry 20100722
-
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
PLoS genetics 20100701
-
Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.
Molecular and cellular biochemistry 20100501
-
Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.
The Journal of biological chemistry 20100409
-
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.
Journal of enzyme inhibition and medicinal chemistry 20100401
-
Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.
Haematologica 20100401
-
p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2.
The Prostate 20100201
-
Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes.
BMC molecular biology 20100101
-
A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening.
Electrophoresis 20100101
-
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
PloS one 20100101
-
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Molecular cancer 20100101
-
The 14-3-3ζ protein binds to the cell adhesion molecule L1, promotes L1 phosphorylation by CKII and influences L1-dependent neurite outgrowth.
PloS one 20100101
-
Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.
Molecular neurodegeneration 20100101
-
Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells.
International journal of oncology 20091101
-
Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses.
International journal of oncology 20091101
-
Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells.
Cancer research 20091015
-
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826
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Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes.
Journal of dermatological science 20090801
-
Involvement of reactive oxygen species in apoptosis induced by pharmacological inhibition of protein kinase CK2.
Annals of the New York Academy of Sciences 20090801
-
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Bioorganic & medicinal chemistry letters 20090601
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DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.
Oncology reports 20090601
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Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.
Bioorganic & medicinal chemistry 20090215
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Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression.
European journal of immunology 20090101
-
Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
BMC cancer 20090101
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The selectivity of inhibitors of protein kinase CK2: an update.
The Biochemical journal 20081101
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Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.
Cellular signalling 20081101
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New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole.
Molecular and cellular biochemistry 20080901
-
Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37.
Molecular and cellular biochemistry 20080901
-
Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.
Molecular and cellular biochemistry 20080901
-
Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers.
American journal of physiology. Regulatory, integrative and comparative physiology 20080801
-
Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity.
Current neurovascular research 20080801
-
Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus.
The Journal of physiology 20080701
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An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.
Molecular & cellular proteomics : MCP 20080601
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Regulation of the epithelial Na+ channel by the protein kinase CK2.
The Journal of biological chemistry 20080509
-
Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.
Clinical and experimental immunology 20080501
-
A role for CK2 upon interkinetic nuclear migration in the cell cycle of retinal progenitor cells.
Developmental neurobiology 20080401
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CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content.
Journal of molecular signaling 20080101
-
Ecto-phosphorylation of CD98 regulates cell-cell interactions.
PloS one 20080101
-
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proceedings of the National Academy of Sciences of the United States of America 20071218
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Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.
Planta medica 20071101
-
The reverse in-gel kinase assay to profile physiological kinase substrates.
Nature methods 20071101
-
Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20070227
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Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 20070201
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Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors.
Chembiochem : a European journal of chemical biology 20070102
-
CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity.
Molecular and cellular biochemistry 20070101
-
Differential regulation of mouse equilibrative nucleoside transporter 1 (mENT1) splice variants by protein kinase CK2.
Molecular membrane biology 20070101
-
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Cell 20060728
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Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.
The American journal of pathology 20060501
-
Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
Molecular cancer research : MCR 20060501
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Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells.
Cancer research 20060215
-
Adaptor heat shock protein complex formation regulates trafficking of the asialoglycoprotein receptor.
American journal of physiology. Gastrointestinal and liver physiology 20060201
-
Transcriptional analysis of calcium-dependent and calcium-independent signalling pathways induced by oligogalacturonides.
Journal of experimental botany 20060101
-
Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
Biochimica et biophysica acta 20051230
-
CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex.
The Journal of biological chemistry 20051202
-
A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44.
Traffic (Copenhagen, Denmark) 20051101
-
Development and exploitation of CK2 inhibitors.
Molecular and cellular biochemistry 20050601
-
Phosphorylation of the acidic domain of Mdm2 by protein kinase CK2.
Molecular and cellular biochemistry 20050601
-
Spinal CK2 regulates nociceptive signaling in models of inflammatory pain.
Pain 20050501
-
Control of hepatitis C: a medicinal chemistry perspective.
Journal of medicinal chemistry 20050113
-
Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae.
Antiviral chemistry & chemotherapy 20050101
-
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Journal of medicinal chemistry 20041202
-
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Acta poloniae pharmaceutica 20041201
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Flow-dependent regulation of endothelial Toll-like receptor 2 expression through inhibition of SP1 activity.
Circulation research 20041001
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2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.
Biochemical and biophysical research communications 20040903
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Expression of the Stp1 LMW-PTP and inhibition of protein CK2 display a cooperative effect on immunophilin Fpr3 tyrosine phosphorylation and Saccharomyces cerevisiae growth.
Cellular and molecular life sciences : CMLS 20040501
-
Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin.
Biochemical and biophysical research communications 20040319
-
TBBz but not TBBt discriminates between two molecular forms of CK2 in vivo and its implications.
Biochemical and biophysical research communications 20031219
-
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
The Biochemical journal 20030915
-
Alternative binding modes of an inhibitor to two different kinases.
European journal of biochemistry 20030801
-
Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.
Biochemical and biophysical research communications 20030620
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Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
European journal of biochemistry 20030401
-
The role of calcium in oligogalacturonide-activated signalling in soybean cells.
Planta 20020801
-
Identification of protein kinase CK2 as a potent kinase of Epstein-Barr virus latent membrane protein 1.
Biochemical and biophysical research communications 20020614
-
Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
The Biochemical journal 20020515
-
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
-
Toward the rational design of protein kinase casein kinase-2 inhibitors.
Pharmacology & therapeutics 20020101
-
Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein science : a publication of the Protein Society 20011101
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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').
FEBS letters 20010504