17422-74-1 | Chromone-3-carboxaldehyde

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$12.00	$9.00
10g	98%	in stock	$21.00	$15.00
25g	98%	in stock	$37.00	$26.00

Description

• Catalog Number: AA92477
• Chemical Name: Chromone-3-carboxaldehyde
• CAS Number: 17422-74-1
• Molecular Formula: C10H6O3
• Molecular Weight: 174.15284
• MDL Number: MFCD00014667
• SMILES: O=Cc1coc2c(c1=O)cccc2
• NSC Number: 291317

Computed Properties

• Complexity: 267
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 1.2

Literature

• Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20121001

• Selected chromone derivatives as inhibitors of monoamine oxidase.

  Bioorganic & medicinal chemistry letters 20120901

• Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities.

  Journal of enzyme inhibition and medicinal chemistry 20120201

• 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.

  The Journal of biological chemistry 20120102

• Synthesis of furo[3,2-b]pyrrole-5-carboxhydrazides and their Cu, Co and Ni complexes.

  TheScientificWorldJournal 20120101

• Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications.

  International journal of molecular sciences 20120101

• Synthesis, characterization and biological activity of some new VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) complexes of chromone based NNO Schiff base derived from 2-aminothiazole.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

• 4-Hy-droxy-3-[(4-hy-droxy-6,7-dimethyl-2-oxo-2H-chromen-3-yl)(4-oxo-4H-chromen-3-yl)meth-yl]-6,7-dimethyl-2H-chromen-2-one.

  Acta crystallographica. Section E, Structure reports online 20101101

• 3-Formylchromones: potential antiinflammatory agents.

  European journal of medicinal chemistry 20100901

• Discovery of novel antitubercular 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives.

  European journal of medicinal chemistry 20100101

• Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.

  Bioorganic & medicinal chemistry 20090415

• Synthesis of quinolines from 3-formylchromone.

  The Journal of organic chemistry 20080801

• Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries.

  Natural product reports 20080801

• Relationship between structure and antioxidative properties of some 3-formylchromone derivatives.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Quantitative structure-cytotoxicity relationship analysis of 3-formylchromone derivatives by a semiempirical molecular-orbital method with the concept of absolute hardness.

  Anticancer research 20080101

• Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.

  Indian journal of pharmaceutical sciences 20080101

• Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones.

  Arzneimittel-Forschung 20070101

• Biological activity of 3-formylchromones and related compounds.

  In vivo (Athens, Greece) 20070101

• In vivo antitumor, in vitro antibacterial activity and alkylating properties of phosphorohydrazine derivatives of coumarin and chromone.

  European journal of medicinal chemistry 20061101

• Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.

  Journal of medicinal chemistry 20060629

• Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells.

  In vivo (Athens, Greece) 20060101

• 3-Formylchromones IV. The rearrangement of 3-formylchromone enamines as a simple, facile route to novel pyrazolo[3,4-b]pyridines and the synthetic utility of the latter.

  Molecules (Basel, Switzerland) 20050831

• Reactions of 3-formylchromone with active methylene and methyl compounds and some subsequent reactions of the resulting condensation products.

  Molecules (Basel, Switzerland) 20050831

• Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.

  Bioorganic & medicinal chemistry letters 20050615

• Induction of apoptosis by beta-diketones in human tumor cells.

  Anticancer research 20040101

• Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.

  Bioorganic & medicinal chemistry letters 20030804