1744-22-5 | 2-Amino-6-(trifluoromethoxy)benzo[d]thiazole

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$15.00	$10.00
1g	98%	in stock	$16.00	$11.00
5g	98%	in stock	$18.00	$12.00
25g	98%	in stock	$44.00	$31.00
100g	98%	in stock	$148.00	$104.00

Description

• Catalog Number: AD65890
• Chemical Name: 2-Amino-6-(trifluoromethoxy)benzo[d]thiazole
• CAS Number: 1744-22-5
• Molecular Formula: C8H5F3N2OS
• Molecular Weight: 234.1983
• MDL Number: MFCD00210213
• SMILES: Nc1nc2c(s1)cc(cc2)OC(F)(F)F

Computed Properties

• Complexity: 238
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 3.6

Upstream Synthesis Route

6-(Trifluoromethoxy)-2-benzothiazolamine, a versatile compound used in chemical synthesis, plays a crucial role in various applications including medicinal chemistry, materials science, and agrochemical research. Its unique structure and properties make it an essential building block for creating novel compounds with diverse functionalities. In organic synthesis, 6-(Trifluoromethoxy)-2-benzothiazolamine serves as a key intermediate for the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its trifluoromethoxy group imparts desirable characteristics like increased lipophilicity and metabolic stability, making it a valuable tool for drug discovery and development. Additionally, this compound is utilized in the production of fluorescent dyes, polymers, and advanced materials due to its ability to modify molecular structures and enhance desired properties. With its wide range of applications and potential for innovation, 6-(Trifluoromethoxy)-2-benzothiazolamine continues to be an indispensable component in the field of chemical synthesis.

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  Journal of neural transmission (Vienna, Austria : 1996) 20080801

• In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1(G93A)).

  Experimental neurology 20080801

• Preface: the state of the science of all motor neuron diseases.

  Physical medicine and rehabilitation clinics of North America 20080801

• Cognitive and behavioral impairment in amyotrophic lateral sclerosis.

  Physical medicine and rehabilitation clinics of North America 20080801

• A strategy for developing effective amyotropic lateral sclerosis pharmacotherapy: from clinical trials to novel pharmacotherapeutic strategies.

  Expert opinion on pharmacotherapy 20080801

• Early intervention in bipolar disorder, part II: therapeutics.

  Early intervention in psychiatry 20080801

• Spontaneous activity in Purkinje cells: multi-electrode recording from organotypic cerebellar slice cultures.

  Brain research 20080707

• TWIK-related two-pore domain potassium channel TREK-1 in carotid endothelium of normotensive and hypertensive mice.

  Cardiovascular research 20080701

• Molecular mechanisms of interaction between the neuroprotective substance riluzole and GABA(A)-receptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20080701

• [Amyotrophic lateral sclerosis. Current clinical trials and underlying pathomechanisms].

  Der Nervenarzt 20080601

• Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-up.

  Journal of clinical psychopharmacology 20080601

• Toward a better understanding of amyotrophic lateral sclerosis.

  Home healthcare nurse 20080601

• Promising avenues of therapeutics for bipolar illness.

  Dialogues in clinical neuroscience 20080601

• [Epidemiology and treatment of amyotrophic lateral sclerosis].

  Soins; la revue de reference infirmiere 20080601

• Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder.

  Psychiatry investigation 20080601

• Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.

  European journal of pharmacology 20080531

• An association study of riluzole serum concentration and survival and disease progression in patients with ALS.

  Clinical pharmacology and therapeutics 20080501

• Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder.

  Biological psychiatry 20080501

• Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

  The European journal of neuroscience 20080501

• Direct effects of riluzole on 5-hydroxytryptamine (5-HT)3 receptor-activated ion currents in NCB-20 neuroblastoma cells.

  Journal of pharmacological sciences 20080501

• Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype.

  Biopharmaceutics & drug disposition 20080401

• Openers of calcium-activated potassium channels and endothelium-dependent hyperpolarizations in the guinea pig carotid artery.

  Naunyn-Schmiedeberg's archives of pharmacology 20080401

• Protection against Parkinson's disease progression: clinical experience.

  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20080401

• Local oscillations of spiking activity in organotypic spinal cord slice cultures.

  The European journal of neuroscience 20080401

• Thalidomide causes sinus bradycardia in ALS.

  Journal of neurology 20080401

• Diagnosis and management of motor neurone disease.

  BMJ (Clinical research ed.) 20080322

• Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: the effect of riluzole treatment.

  Clinical neurology and neurosurgery 20080301

• In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity.

  Chemical research in toxicology 20080301

• Motor neuron disease associated with multiple myeloma.

  The International journal of neuroscience 20080301

• [Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301

• Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities.

  Respiratory physiology & neurobiology 20080227

• Neuroprotection and repair.

  Journal of the neurological sciences 20080215

• Transition between two excitabilities in mesencephalic V neurons.

  Journal of computational neuroscience 20080201

• Molecular insights and therapeutic targets in amyotrophic lateral sclerosis.

  CNS & neurological disorders drug targets 20080201

• Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

  European journal of pharmacology 20080114

• Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells.

  Life sciences 20080102

• Riluzole and D-amphetamine interactions in humans.

  Progress in neuro-psychopharmacology & biological psychiatry 20080101

• Neuroprotective effects of riluzole in Huntington's disease.

  European journal of nuclear medicine and molecular imaging 20080101

• What role do pacemakers play in the generation of respiratory rhythm?

  Advances in experimental medicine and biology 20080101

• Contribution of pacemaker neurons to respiratory rhythms generation in vitro.

  Advances in experimental medicine and biology 20080101

• Timeliness of diagnosis in motor neurone disease: a population-based study.

  The Ulster medical journal 20080101

• Design, power, and interpretation of studies in the standard murine model of ALS.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20080101

• Molecular and cellular limits to somatosensory specificity.

  Molecular pain 20080101

• Therapeutic potential of fluoxetine in neurological disorders.

  CNS neuroscience & therapeutics 20080101

• Management of amyotrophic lateral sclerosis.

  Drugs 20080101

• Social uses of personal health information within PatientsLikeMe, an online patient community: what can happen when patients have access to one another's data.

  Journal of medical Internet research 20080101

• Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

  PloS one 20080101

• Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection.

  PloS one 20080101

• Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays.

  International journal of biological sciences 20080101

• Riluzole in the treatment of mood and anxiety disorders.

  CNS drugs 20080101

• The endocannabinoid system in amyotrophic lateral sclerosis.

  Current pharmaceutical design 20080101

• The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile.

  Nutrition journal 20080101

• TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.

  BMC neuroscience 20080101

• Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury.

  Neurosurgical focus 20080101

• Anaesthesia for ophthalmologic surgical procedures in a patient with advanced amyotrophic lateral sclerosis: a case report.

  Cases journal 20080101

• Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats.

  Molecular pain 20080101

• Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region.

  Journal of neuroscience research 20071201

• Insulin increases retinal hemorrhage in mild oxygen-induced retinopathy in the rat: inhibition by riluzole.

  Investigative ophthalmology & visual science 20071201

• An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder.

  Journal of child and adolescent psychopharmacology 20071201

• Oral administration of memantine prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.

  Journal of clinical neurology (Seoul, Korea) 20071201

• Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20071128

• [New options in the treatment of depression].

  Fortschritte der Neurologie-Psychiatrie 20071101

• Evaluation of the systemic use of riluzole in post-traumatic facial nerve regeneration: experimental study in rabbits.

  Acta oto-laryngologica 20071101

• Postnatal electrical and morphological abnormalities in lumbar motoneurons from transgenic mouse models of amyotrophic lateral sclerosis.

  Archives italiennes de biologie 20071101

• Persistently active, pacemaker-like neurons in neocortex.

  Frontiers in neuroscience 20071101

• [Association between amytrophic lateral sclerosis and Parkinson's disease].

  Medicina clinica 20071006

• Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood-brain barrier.

  Journal of neurochemistry 20071001

• Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety.

  Neuropharmacology 20071001

• Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20071001

• Clinical care of patients with amyotrophic lateral sclerosis.

  The Lancet. Neurology 20071001

• [Clinical trials of ultra-high-dose methylcobalamin in ALS].

  Brain and nerve = Shinkei kenkyu no shinpo 20071001

• Impairment of GH secretion in amyotrophic lateral sclerosis is not affected by riluzole treatment.

  Journal of endocrinological investigation 20071001

• Riluzole in Huntington's disease: a 3-year, randomized controlled study.

  Annals of neurology 20070901

• Are pacemaker properties required for respiratory rhythm generation in adult turtle brain stems in vitro?

  American journal of physiology. Regulatory, integrative and comparative physiology 20070801

• Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.

  Journal of neurophysiology 20070801

• The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.

  British journal of pharmacology 20070801

• Good practice in the management of amyotrophic lateral sclerosis: clinical guidelines. An evidence-based review with good practice points. EALSC Working Group.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20070801

• Current clinical trials in amyotrophic lateral sclerosis.

  Expert opinion on investigational drugs 20070801

• Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070801

• Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070801

• Palliative care for patients with amyotrophic lateral sclerosis: 'prepare for the worst and hope for the best'.

  JAMA 20070711

• Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070701

• Therapeutic potential of neuronal two-pore domain potassium-channel modulators.

  Current opinion in investigational drugs (London, England : 2000) 20070701

• Anti-glutamatergic effect of riluzole: comparison with valproic acid.

  Neuroscience 20070615

• Differential modulation by tetraethylammonium of the processes underlying network bursting in the neonatal rat spinal cord in vitro.

  Neuroscience 20070608

• Persistent sodium current in preBotzinger neurons is not necessary for respiratory rhythm generation in the neonatal mouse?

  The Journal of physiology 20070601

• Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice.

  Anesthesia and analgesia 20070601

• Three soccer playing friends with simultaneous amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20070601

• Early use of non-invasive ventilation prolongs survival in subjects with ALS.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20070601

• Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection.

  Journal of pharmaceutical and biomedical analysis 20070509

• Riluzole-induced oscillations in spinal networks.

  Journal of neurophysiology 20070501

• Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

  The European journal of neuroscience 20070501

• Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070425

• Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model.

  Behavioural brain research 20070416

• Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis.

  The Journal of physiology 20070415

• Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation.

  The Journal of physiology 20070415

• Persistent inward currents in rat ventral horn neurones.

  The Journal of physiology 20070415

• The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

• Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.

  Neurobiology of disease 20070401

• [A strategy to develop effective ALS therapy].

  Brain and nerve = Shinkei kenkyu no shinpo 20070401

• Efficacy of riluzole: who are the patients enrolled in the studies?

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20070401

• Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?

  Neurological research 20070401

• Effects of riluzole and flufenamic acid on eupnea and gasping of neonatal mice in vivo.

  Neuroscience letters 20070330

• Amyotrophic lateral sclerosis: a global threat with a possible difference in risk across ethnicities.

  Neurology 20070327

• Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms.

  Biological psychiatry 20070315

• Neuroprotective agents: is effective on toxicity in glial cells?

  Cellular and molecular neurobiology 20070301

• Opposing inward and outward conductances regulate rebound discharges in olfactory mitral cells.

  Journal of neurophysiology 20070301

• The whisking rhythm generator: a novel mammalian network for the generation of movement.

  Journal of neurophysiology 20070301

• Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.

  Journal of neurophysiology 20070301

• Differential neuroprotective effects of a minocycline-based drug cocktail in transient and permanent focal cerebral ischemia.

  Experimental neurology 20070301

• A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.

  Journal of neurochemistry 20070301

• Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.

  Cancer research 20070301

• Riluzole and amyotrophic lateral sclerosis survival: a population-based study in southern Italy.

  European journal of neurology 20070301

• Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

  American journal of physiology. Heart and circulatory physiology 20070201

• A systematic review of the treatment studies in Huntington's disease since 1990.

  Expert opinion on pharmacotherapy 20070201

• Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  The Cochrane database of systematic reviews 20070124

• Delayed riluzole treatment is able to rescue injured rat spinal motoneurons.

  Neuroscience 20070119

• Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels.

  Respiratory physiology & neurobiology 20070115

• Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers.

  The Journal of physiology 20070101

• Monozygotic twins suffering from Huntington's disease show different cognitive and behavioural symptoms.

  European neurology 20070101

• Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.

  BMC genomics 20070101

• Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with trichotillomania.

  The Journal of clinical psychiatry 20070101

• Glutamate-modulating drugs & the treatment of mental disorders.

  Journal of psychosocial nursing and mental health services 20070101

• Stem cell therapy for autism.

  Journal of translational medicine 20070101

• Vitamin E deficiency and risk of equine motor neuron disease.

  Acta veterinaria Scandinavica 20070101

• [Experimental models of amyotrophic lateral sclerosis].

  Neurologia (Barcelona, Spain) 20070101

• [Subtle brain abnormalities in adrenomyeloneuropathy].

  Journal de radiologie 20070101

• Outcome of sporadic amyotrophic lateral sclerosis treated with non-invasive ventilation and riluzole.

  Medicina 20070101

• Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation.

  Progress in brain research 20070101

• An acute, life-threatening, hypersensitivity reaction to riluzole.

  Neurology 20061226

• Hyperimmune goat serum for amyotrophic lateral sclerosis.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20061201

• Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors.

  Journal of clinical psychopharmacology 20061201

• Riluzole promotes cell survival and neurite outgrowth in rat sensory neurones in vitro.

  The European journal of neuroscience 20061201

• Therapeutic Strategies in Huntington's Disease.

  Journal of clinical neurology (Seoul, Korea) 20061201

• The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo.

  Neuroscience 20061103

• Role of persistent sodium current in bursting activity of mouse neocortical networks in vitro.

  Journal of neurophysiology 20061101

• [Management and care for patients with ALS].

  Rinsho shinkeigaku = Clinical neurology 20061101

• Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease.

  Neuroscience letters 20061030

• An important functional role of persistent Na+ current in carotid body hypoxia transduction.

  Journal of applied physiology (Bethesda, Md. : 1985) 20061001

• Contribution of persistent Na+ current and M-type K+ current to somatic bursting in CA1 pyramidal cells: combined experimental and modeling study.

  Journal of neurophysiology 20061001

• Interaction of riluzole with the closed inactivated state of Kv4.3 channels.

  The Journal of pharmacology and experimental therapeutics 20061001

• MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).

  Journal of neuroimmunology 20061001

• Placebo-controlled trial of riluzole in multiple system atrophy.

  European journal of neurology 20061001

• Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats.

  Journal of neurophysiology 20060901

• Glutamate release inhibition ineffective in levodopa-induced motor complications.

  Movement disorders : official journal of the Movement Disorder Society 20060901

• Growth hormone secretion is impaired in amyotrophic lateral sclerosis.

  Clinical endocrinology 20060901

• Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release.

  The European journal of neuroscience 20060901

• Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging.

  Journal of neurology 20060801

• Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones.

  The Journal of physiology 20060801

• Consequences of misdiagnosing mitochondrial disorder.

  The International journal of neuroscience 20060801

• Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?

  Archives of neurology 20060801

• Effect of riluzole on Ca2+ movement and cytotoxicity in Madin-Darby canine kidney cells.

  Human & experimental toxicology 20060801

• Neuroprotective agents for clinical trials in ALS: a systematic assessment.

  Neurology 20060711

• Characteristics of taurine release in slices from adult and developing mouse brain stem.

  Amino acids 20060701

• Misdiagnosis and missed diagnoses in patients with ALS.

  JAAPA : official journal of the American Academy of Physician Assistants 20060701

• Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060701

• Audit of outcomes in motor neuron disease (MND) patients treated with riluzole.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20060601

• Factors correlated with NPPV use in ALS.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20060601

• Future prospects in depression research.

  Dialogues in clinical neuroscience 20060601

• [What are the etiological medical therapies in amyotrophic lateral sclerosis?].

  Revue neurologique 20060601

• [Etiological drug therapy for amyotrophic lateral sclerosis].

  Revue neurologique 20060601

• Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

  European journal of pharmacology 20060524

• Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.

  Expert reviews in molecular medicine 20060524

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Delayed amnesic syndrome after riluzole autointoxication in Huntington disease.

  Neurology 20060411

• Norepinephrine differentially modulates different types of respiratory pacemaker and nonpacemaker neurons.

  Journal of neurophysiology 20060401

• Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells.

  Journal of neurochemistry 20060401

• Visual hallucinations from the addition of riluzole to memantine and bupropion.

  Journal of clinical psychopharmacology 20060401

• Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.

  European journal of pharmacology 20060327

• Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease.

  Experimental neurology 20060301

• Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population.

  Journal of neurology, neurosurgery, and psychiatry 20060301

• The alkaloid alstonine: a review of its pharmacological properties.

  Evidence-based complementary and alternative medicine : eCAM 20060301

• [Recent advances in the study of arachidonic acid-sensitive and mechano-gated tandem-pore-domain potassium channels--TREK].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060301

• Two-pore-domain potassium channels support anion secretion from human airway Calu-3 epithelial cells.

  Pflugers Archiv : European journal of physiology 20060201

• The glutamate release inhibitor riluzole attenuates the formation of conditioned place aversion induced by naloxone in rats undergoing a single morphine exposure.

  Brain research 20060119

• Pentoxifylline in ALS: a double-blind, randomized, multicenter, placebo-controlled trial.

  Neurology 20060110

• Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.

  Neurobiology of disease 20060101

• Pharmacological characterization of ionic currents that regulate high-frequency spontaneous activity of electromotor neurons in the weakly electric fish, Apteronotus leptorhynchus.

  Journal of neurobiology 20060101

• The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions.

  Neuroscience 20060101

• Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia.

  Neuroscience 20060101

• Riluzole therapy for motor neurone disease: an early Australian experience (1996-2002).

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20060101

• [Strong suspicion of lung toxicity due to riluzole].

  Archivos de bronconeumologia 20060101

• Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation.

  Journal of neuroinflammation 20060101

• Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder.

  NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 20060101

• Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.

  BMC neurology 20060101

• COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.

  BMC neurology 20060101

• Pharmacological approaches to repair the injured spinal cord.

  Journal of neurotrauma 20060101

• Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis.

  BMC neurology 20060101

• Translating preclinical insights into effective human trials in ALS.

  Biochimica et biophysica acta 20060101

• The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

  Biochimica et biophysica acta 20060101

• Pharmacological management of Huntington's disease: an evidence-based review.

  Current pharmaceutical design 20060101

• Glutamate receptors in neuroinflammatory demyelinating disease.

  Mediators of inflammation 20060101

• Amyotrophic lateral sclerosis: recent advances and future therapies.

  Current opinion in neurology 20051201

• Riluzole inhibits VEGF-induced endothelial cell proliferation in vitro and hyperoxia-induced abnormal vessel formation in vivo.

  Investigative ophthalmology & visual science 20051201

• EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives.

  European journal of neurology 20051201

• Open-label trial of riluzole in generalized anxiety disorder.

  The American journal of psychiatry 20051201

• Diagnostic investigation and multidisciplinary management in motor neuron disease.

  Journal of neurology 20051201

• Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder.

  The Journal of clinical psychiatry 20051101

• Access to palliative care for people with motor neurone disease in New Zealand: a patient's perspective.

  The New Zealand medical journal 20051028

• Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026

• Minocycline in amyotrophic lateral sclerosis: a pilot study.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20051001

• Beyond monoamines: glutamatergic function in mood disorders.

  CNS spectrums 20051001

• Rilutek should be subsidised.

  Nursing New Zealand (Wellington, N.Z. : 1995) 20051001

• Neuroprotective therapy in Parkinson's disease: current status and new directions from experimental and genetic clues.

  Journal of clinical neurology (Seoul, Korea) 20051001

• Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial.

  Biological psychiatry 20050901

• Management strategies for patients with amyotrophic lateral sclerosis from diagnosis through death.

  The neurologist 20050901

• Glutamate modulators as novel interventions for mood disorders.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20050901

• A transitional period of Ca2+-dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells.

  The Journal of physiology 20050815

• Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy).

  Journal of neural transmission (Vienna, Austria : 1996) 20050801

• Riluzole: a glimmer of hope in the treatment of motor neurone disease.

  The Medical journal of Australia 20050801

• Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones.

  The Journal of physiology 20050715

• Neuroprotective effect of riluzole in acute noise-induced hearing loss.

  Neuroreport 20050713

• Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia.

  Experimental neurology 20050701

• Current status of clinical trials for acute spinal cord injury.

  Injury 20050701

• Noise of the slowly inactivating Na current in suprachiasmatic nucleus neurons.

  Neuroreport 20050621

• Glutamate inhibition in MS: the neuroprotective properties of riluzole.

  Journal of the neurological sciences 20050615

• Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?

  Psychopharmacology 20050601

• Mechanisms of Na+ and Ca2+ influx into respiratory neurons during hypoxia.

  Neuropharmacology 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• [An experience nursing a patient with amyotrophic lateral sclerosis using the theory of self-care].

  Hu li za zhi The journal of nursing 20050601

• Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050525

• Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice.

  Journal of neural transmission (Vienna, Austria : 1996) 20050501

• High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.

  Journal of neural transmission (Vienna, Austria : 1996) 20050501

• Iron alters glutamate secretion by regulating cytosolic aconitase activity.

  American journal of physiology. Cell physiology 20050501

• Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability.

  Journal of neurophysiology 20050501

• A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS.

  Neurology 20050412

• Riluzole: a glimmer of hope in the treatment of motor neurone disease.

  The Medical journal of Australia 20050404

• [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

  Brain : a journal of neurology 20050401

• Simple determination of riluzole in rat brain by high-performance liquid chromatography and spectrophotometric detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

• Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

  The Journal of physiology 20050315

• The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage --> glutamate release --> damage --> glutamate release --> etc.

  Brain research 20050315

• The ALS/MND prevalence in Sweden estimated by riluzole sales statistics.

  Acta neurologica Scandinavica 20050301

• Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence.

  Addiction (Abingdon, England) 20050301

• Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis.

  British journal of clinical pharmacology 20050301

• New ideas for therapy in ALS.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20050301

• Prognostic factors for survival in amyotrophic lateral sclerosis patients treated with riluzole.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20050301

• An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression.

  Biological psychiatry 20050215

• Development of novel therapies for Huntington's disease: hope and challenge.

  Acta pharmacologica Sinica 20050201

• Advances in clinical trials for amyotrophic lateral sclerosis.

  Current neurology and neuroscience reports 20050201

• Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112

• The effects of hypoxia on the modulation of human TREK-1 potassium channels.

  The Journal of physiology 20050101

• Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid-sensitive chloride channels.

  The European journal of neuroscience 20050101

• Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis.

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20050101

• Glutamate transporter: an unexpected target for some antibiotics.

  Molecular pain 20050101

• Primary progressive multiple sclerosis : current and future treatment options.

  CNS drugs 20050101

• Inhibition of the cloned delayed rectifier K+ channels, Kv1.5 and Kv3.1, by riluzole.

  Neuroscience 20050101

• The cost-effectiveness of early noninvasive ventilation for ALS patients.

  BMC health services research 20050101

• Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states.

  Molecular pain 20050101

• The use of herbal supplements and alternative therapies by patients with amyotrophic lateral sclerosis (ALS).

  Journal of herbal pharmacotherapy 20050101

• Excitotoxicity and amyotrophic lateral sclerosis.

  Neuro-degenerative diseases 20050101

• Clinical trials in ALS: what did we learn from recent trials in humans?

  Neuro-degenerative diseases 20050101

• Complex genetics of amyotrophic lateral sclerosis.

  American journal of human genetics 20041201

• Unexpected decline in survival from amyotrophic lateral sclerosis/motor neurone disease.

  Journal of neurology, neurosurgery, and psychiatry 20041201

• Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.

  Journal of neural transmission (Vienna, Austria : 1996) 20041201

• Changes in the management of ALS since the publication of the AAN ALS practice parameter 1999.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20041201

• [Amyotrophic lateral sclerosis. Fatal diagnosis -- how still can be helped?].

  MMW Fortschritte der Medizin 20041118

• A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis.

  Biomedical chromatography : BMC 20041101

• Cytoplasmic body myopathy masquerading as motor neuron disease.

  Muscle & nerve 20041101

• Enhanced release of synaptic glutamate underlies the potentiation of oxygen-glucose deprivation-induced neuronal injury after induction of NOS-2.

  Experimental neurology 20041101

• The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis.

  Expert opinion on drug safety 20041101

• Riluzole augmentation for treatment-resistant depression.

  The American journal of psychiatry 20041101

• Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole.

  Journal of neuroscience research 20041015

• Clinical trials of neuroprotection for Parkinson's disease.

  Neurology 20041012

• Easier access to motor neurone drug.

  Nursing New Zealand (Wellington, N.Z. : 1995) 20041001

• Riluzole slows the progression of neuromuscular dysfunction in the wobbler mouse motor neuron disease.

  Brain research 20040903

• Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds.

  Journal of neurophysiology 20040901

• Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients.

  Journal of neurochemistry 20040901

• Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model.

  Journal of neurology 20040901

• Disease-modifying drug therapies.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20040901

• INaP underlies intrinsic spiking and rhythm generation in networks of cultured rat spinal cord neurons.

  The European journal of neuroscience 20040801

• Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses.

  Neuron glia biology 20040801

• Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia.

  Neuron 20040708

• Neuroprotection in Parkinson's disease: an elusive goal.

  Current neurology and neuroscience reports 20040701

• Frequency, timing and outcome of gastrostomy tubes for amyotrophic lateral sclerosis/motor neurone disease--a record linkage study from the Scottish Motor Neurone Disease Register.

  Journal of neurology 20040701

• Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells.

  The Journal of biological chemistry 20040625

• Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury.

  Experimental neurology 20040601

• Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20040601

• Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20040601

• Transcranial magnetic stimulation: applications for neuropsychopharmacology.

  Journal of psychopharmacology (Oxford, England) 20040601

• Neural plasticity: consequences of stress and actions of antidepressant treatment.

  Dialogues in clinical neuroscience 20040601

• Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking.

  Dialogues in clinical neuroscience 20040601

• Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats.

  Life sciences 20040528

• Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis.

  Neurology 20040525

• Patient page. Treatment and quality of life for people with ALS.

  Neurology 20040525

• Riluzole-induced neutropenia.

  Neurology 20040511

• [Neuronal background two-P-domain potassium channels: molecular and functional aspects].

  Medecine sciences : M/S 20040501

• New pharmacological strategies to restore hearing and treat tinnitus.

  Acta oto-laryngologica 20040501

• Is the persistent sodium current a specific target of anti-absence drugs?

  Neuroreport 20040429

• Liquid chromatographic assay for riluzole in mouse plasma and central nervous system tissues.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

• Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.

  Current biology : CB 20040406

• Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine.

  Psychopharmacology 20040401

• Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy.

  Neuroscience letters 20040318

• The epidemiology of amyotrophic lateral sclerosis (ALS/MND) in people aged 80 or over.

  Age and ageing 20040301

• Huntington's disease: present treatments and future therapeutic modalities.

  International clinical psychopharmacology 20040301

• Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.

  The Journal of clinical investigation 20040215

• Effects of axonal injury on ganglion cell survival and glutamate homeostasis.

  Brain research bulletin 20040215

• Riluzole-sensitive slowly inactivating sodium current in rat suprachiasmatic nucleus neurons.

  Journal of neurophysiology 20040201

• Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies.

  Molecular neurobiology 20040201

• [Physiopathology of ALS: therapeutic approach].

  Revue neurologique 20040201

• Riluzole enhances glutamate uptake in rat astrocyte cultures.

  Cellular and molecular neurobiology 20040201

• Riluzole-induced methemoglobinemia.

  Annals of emergency medicine 20040201

• Neurochemical changes of the extracellular concentrations of glutamate and aspartate in the nucleus accumbens of rats after chronic administration of morphine.

  European journal of pharmacology 20040112

• Selective effects of potassium elevations on glutamate signaling and action potential conduction in hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107

• An open-label trial of riluzole in patients with treatment-resistant major depression.

  The American journal of psychiatry 20040101

• Neuropsychotherapeutics in the UK: what has been the impact of NICE on prescribing?

  CNS drugs 20040101

• Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes).

  Neuroscience 20040101

• Effect of riluzole on dyskinesia and duration of the on state in Parkinson disease patients: a double-blind, placebo-controlled pilot study.

  Clinical neuropharmacology 20040101

• [Tolerability of riluzole: a review of the literature].

  La Clinica terapeutica 20040101

• Riluzole enhances the anti-seizure action of conventional antiepileptic drugs against pentetrazole-induced convulsions in mice.

  Polish journal of pharmacology 20040101

• Prognosis in amyotrophic lateral sclerosis: a population-based study.

  Neurology 20031223

• Dosage effects of riluzole in Huntington's disease: a multicenter placebo-controlled study.

  Neurology 20031209

• The management of motor neurone disease.

  Journal of neurology, neurosurgery, and psychiatry 20031201

• Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis.

  Brain research 20031107

• Riluzole inhibits spontaneous Ca2+ signaling in neuroendocrine cells by activation of K+ channels and inhibition of Na+ channels.

  British journal of pharmacology 20031101

• A phase 1 trial of riluzole in spinal muscular atrophy.

  Archives of neurology 20031101

• Effect of riluzole (Rilutek) treatment on plasma amino acid percentages in amyotrophic lateral sclerosis patients.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20031101

• Riluzole serum concentrations in patients with ALS: associations with side effects and symptoms.

  Neurology 20031028

• Hypersensitivity pneumonitis possibly caused by riluzole therapy in ALS.

  Neurology 20031028

• Identification and prediction of promiscuous aggregating inhibitors among known drugs.

  Journal of medicinal chemistry 20031009

• The use of the potassium channel activator riluzole to test whether potassium channels mediate the capacity of isoflurane to produce immobility.

  Anesthesia and analgesia 20031001

• Riluzole attenuates spinal muscular atrophy disease progression in a mouse model.

  Muscle & nerve 20031001

• Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996-2000.

  Journal of neurology, neurosurgery, and psychiatry 20030901

• Riluzole for ALS: what is the evidence?

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20030901

• Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20030901

• Multiple system atrophy: an update.

  Movement disorders : official journal of the Movement Disorder Society 20030901

• ALS treatment strikes out while trying for a homer: the topiramate trial.

  Neurology 20030826

• Intrinsic spontaneous activity and subthreshold oscillations in neurones of the rat dorsal column nuclei in culture.

  The Journal of physiology 20030815

• Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?

  Current opinion in neurology 20030801

• Huntington's disease: prospects for neuroprotective therapy 10 years after the discovery of the causative genetic mutation.

  Current opinion in neurology 20030801

• Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: implications for Huntington's disease.

  The European journal of neuroscience 20030801

• Riluzole and blood pressure in multiple system atrophy.

  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20030801

• Ulcerative colitis and motor neurone disease: causal or coincidental?

  Singapore medical journal 20030801

• A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters.

  Acta neurologica Scandinavica 20030701

• Riluzole, an inhibitor of glutamatergic transmission, suppresses levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.

  Pharmacology & toxicology 20030701

• Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies.

  The European journal of neuroscience 20030701

• Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation.

  European journal of pharmacology 20030627

• Actions of the sodium channel inhibitor 202W92 on rat midbrain dopaminergic neurons.

  Synapse (New York, N.Y.) 20030601

• Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder.

  Psychopharmacology 20030501

• Efficacy, safety and cost of new drugs acting on the central nervous system.

  European journal of clinical pharmacology 20030501

• Efficient three-drug cocktail for disease induced by mutant superoxide dismutase.

  Annals of neurology 20030401

• Large-conductance Ca2+- activated K+ channels:physiological role and pharmacology.

  Current medicinal chemistry 20030401

• Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401

• An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000.

  Journal of neurology 20030401

• Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.

  The Journal of pharmacology and experimental therapeutics 20030301

• Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030301

• Interferon beta-1a in primary progressive multiple sclerosis.

  Journal of the neurological sciences 20030215

• Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.

  The Journal of biological chemistry 20030207

• Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201

• Drug therapy for amyotrophic lateral sclerosis: Where are we now?

  IDrugs : the investigational drugs journal 20030201

• Amyotrophic lateral sclerosis: progress and prospects for treatment.

  Drugs 20030101

• Pharmacology of neuronal background potassium channels.

  Neuropharmacology 20030101

• Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice.

  Neuroscience 20030101

• Prospects for the pharmacotherapy of amyotrophic lateral sclerosis : old strategies and new paradigms for the third millennium.

  CNS drugs 20030101

• Effect of riluzole on MK-801 and amphetamine-induced hyperlocomotion.

  Neuropsychobiology 20030101

• Involvement of glutamate in ischemic neurodegeneration in isolated retina.

  Visual neuroscience 20030101

• Pharmacology of transcranial direct current stimulation: missing effect of riluzole.

  Supplements to Clinical neurophysiology 20030101

• Early symptom progression rate is related to ALS outcome: a prospective population-based study.

  Neurology 20021224

• An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1.

  The Journal of biological chemistry 20021220

• The crude extract from the sea anemone, Bunodosoma caissarum elicits convulsions in mice: possible involvement of the glutamatergic system.

  Toxicon : official journal of the International Society on Toxinology 20021201

• The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20021201

• Management of motor neurone disease.

  Postgraduate medical journal 20021201

• Effect of riluzole on cytosolic Ca2+ increase in human osteosarcoma cells.

  Pharmacology 20021101

• Interaction of high concentrations of riluzole with recombinant skeletal muscle sodium channels and adult-type nicotinic receptor channels.

  Muscle & nerve 20021001

• Therapeutic developments in the treatment of amyotrophic lateral sclerosis.

  Expert opinion on investigational drugs 20021001

• Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis.

  Current drug targets. CNS and neurological disorders 20021001

• Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020915

• Controversies about databases.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020901

• Limitations of inferences from observational databases in amyotrophic lateral sclerosis: all that glitters is not gold.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020901

• Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole.

  European journal of pharmacology 20020802

• Molsidomine potentiates the protective activity of GYKI 52466, a non-NMDA antagonist, MK-801, a non-competitive NMDA antagonist, and riluzole against electroconvulsions in mice.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801

• Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020801

• Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus.

  Neurosurgery 20020801

• Early symptom progression rate is related to ALS outcome: a prospective population-based study.

  Neurology 20020709

• Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons.

  Neuroreport 20020702

• Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis.

  Acta neurologica Scandinavica 20020701

• Effect of chronic treatment with riluzole on the nigrostriatal dopaminergic system in weaver mutant mice.

  Experimental neurology 20020701

• Glutamate transporters and retinal excitotoxicity.

  Glia 20020701

• Riluzole prolongs survival time and alters nuclear inclusion formation in a transgenic mouse model of Huntington's disease.

  Movement disorders : official journal of the Movement Disorder Society 20020701

• A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test.

  European journal of pharmacology 20020612

• Therapies in amyotrophic lateral sclerosis-beyond riluzole.

  Current opinion in pharmacology 20020601

• Respiratory rhythm: an emergent network property?

  Neuron 20020530

• Riluzole treatment in advanced ALS.

  Journal of neurology 20020501

• A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis.

  Journal of neurology 20020501

• A sequential procedure for comparing two experimental treatments with a control.

  Journal of biopharmaceutical statistics 20020501

• Sample size calculation for a proof of concept study.

  Journal of biopharmaceutical statistics 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Emerging strategies for drug development in motor neuron disease.

  Expert opinion on investigational drugs 20020401

• Workshop on primary progressive multiple sclerosis: meeting summary.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20020401

• Interaction between vanilloid and glutamate receptors in the central modulation of nociception.

  European journal of pharmacology 20020329

• Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole.

  Synapse (New York, N.Y.) 20020315

• Riluzole and olanzapine in Huntington's disease.

  European journal of neurology 20020301

• Is glutamate involved in transient lower esophageal sphincter relaxations?

  Digestive diseases and sciences 20020301

• A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease.

  Parkinsonism & related disorders 20020301

• How useful are retrospective studies in evaluating therapeutic interventions?

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020301

• Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020301

• Long-term safety of riluzole in amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020301

• Changes in motor unit numbers in patients with ALS: a longitudinal study using the adapted multiple point stimulation method.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020301

• ALS, motor neuron disease, and related disorders: a personal approach to diagnosis and management.

  Seminars in neurology 20020301

• Enhancing synaptic plasticity and cellular resilience to develop novel, improved treatments for mood disorders.

  Dialogues in clinical neuroscience 20020301

• Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function.

  Neuropharmacology 20020201

• Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons.

  Journal of neurophysiology 20020201

• Pharmacological characterization of a non-inactivating outward current observed in mouse cerebellar Purkinje neurones.

  British journal of pharmacology 20020201

• Apraxia of eyelid closure in Huntington's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 20020201

• Neuroprotective effect of riluzole in a primate model of Parkinson's disease: behavioral and histological evidence.

  Movement disorders : official journal of the Movement Disorder Society 20020101

• Riluzole therapy in cervical dystonia.

  Movement disorders : official journal of the Movement Disorder Society 20020101

• Adjunctive modafinil in ALS.

  The Journal of neuropsychiatry and clinical neurosciences 20020101

• Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig.

  Neuroscience 20020101

• Cost effectiveness of treatments for amyotrophic lateral sclerosis: a review of the literature.

  PharmacoEconomics 20020101

• A fair innings for NICE?

  PharmacoEconomics 20020101

• Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  The Cochrane database of systematic reviews 20020101

• [Tolerance of riluzole in a phase IIIb clinical trial].

  Therapie 20020101

• Voltage-gated sodium ion channels in prostate cancer: expression and activity.

  Anticancer research 20020101

• Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity.

  Molecular psychiatry 20020101

• Measures of quality of life: pro.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020101

• Survival endpoint: pro.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020101

• Cost effectiveness: summary.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20020101

• Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole.

  Progress in brain research 20020101

• Amyotrophic lateral sclerosis: practical aspects of care.

  The journal of spinal cord medicine 20020101

• Disease progression in amyotrophic lateral sclerosis. Identifying the cost-utility of riluzole by disease stage.

  The European journal of health economics : HEPAC : health economics in prevention and care 20020101

• Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors.

  Brain research 20011220

• Amyotrophic lateral sclerosis associated with pregnancy.

  Neurology India 20011201

• Neuroprotective effect of riluzole in MPTP-treated mice.

  Brain research 20011109

• Riluzole suppresses post-sigh, but not spontaneous apnoeas during sleep in rats.

  The Journal of pharmacy and pharmacology 20011101

• Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6-OHDA lesion in the rat brain.

  Movement disorders : official journal of the Movement Disorder Society 20011101

• The cost utility analysis of riluzole for the treatment of amyotrophic lateral sclerosis in the UK.

  Journal of the neurological sciences 20011015

• Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS.

  Journal of the neurological sciences 20011015

• Amyotrophic lateral sclerosis care in Italy: a nationwide study in neurological centers.

  Journal of the neurological sciences 20011015

• Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.

  Neuroscience letters 20011012

• Neuroprotective agent riluzole dramatically slows inactivation of Kv1.4 potassium channels by a voltage-dependent oxidative mechanism.

  The Journal of pharmacology and experimental therapeutics 20011001

• Amyotrophic lateral sclerosis: current understanding.

  The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20011001

• Riluzole in Huntington's disease (HD): an open label study with one year follow up.

  Journal of neurology 20011001

• Intoxication with riluzole in Huntington's disease.

  Neurology 20010925

• Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes.

  Neuroscience letters 20010914

• Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients.

  Neurology 20010911

• Riluzole for motor neurone disease. Reply from chairman of appraisal committee at NICE.

  BMJ (Clinical research ed.) 20010908

• Any placebo controlled trial of riluzole would surely be unethical now.

  BMJ (Clinical research ed.) 20010908

• Mechanisms of cell death and treatment prospects in motor neuron disease.

  Hong Kong medical journal = Xianggang yi xue za zhi 20010901

• The Rilutek (riluzole) Global Early Access Programme: an open-label safety evaluation in the treatment of amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20010901

• Effect of riluzole on the acquisition and expression of amygdala kindling.

  Epilepsy research 20010801

• [Amyotrophic lateral sclerosis].

  Deutsche medizinische Wochenschrift (1946) 20010727

• Riluzole-induced acute pancreatitis.

  The American journal of gastroenterology 20010701

• Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse.

  Neurochemical research 20010701

• Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats.

  Neuroscience letters 20010608

• Effects of riluzole on N-methyl-D-aspartate-induced tyrosine phosphorylation in the rat hippocampus.

  Brain research 20010608

• Pharmacological modulation of SK3 channels.

  Neuropharmacology 20010601

• The treatment of motor neurone disease.

  The Practitioner 20010601

• Clinical trials in ALS: an overview.

  Seminars in neurology 20010601

• Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells.

  Archives of toxicology 20010601

• Riluzole for motor neurone disease. More trials are needed.

  BMJ (Clinical research ed.) 20010526

• Riluzole for motor neurone disease. Large, more economical trial is needed.

  BMJ (Clinical research ed.) 20010526

• Riluzole for motor neurone disease. Ambiguous diagnostic criteria mean that wide variations in elgibility may still persist.

  BMJ (Clinical research ed.) 20010526

• Motor neuron disease.

  Physical medicine and rehabilitation clinics of North America 20010501

• [Hepatotoxicity of medications].

  Presse medicale (Paris, France : 1983) 20010414

• Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole.

  Journal of neurosurgery 20010401

• Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis.

  Annals of neurology 20010401

• Interaction of the neuroprotective drug riluzole with GABA(A) and glycine receptor channels.

  European journal of pharmacology 20010301

• Clinical trials: the past, a lesson for the future.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20010301

• Slowing down ALS--is this good or bad?

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20010301

• Examining the evidence about treatment in ALS/MND.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20010301

• A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20010301

• The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons.

  The European journal of neuroscience 20010101

• The glutamate antagonist riluzole and its effects upon basal and stress-induced activity of the human hypothalamus-pituitary-adrenocortical system in elderly subjects.

  Neuropsychobiology 20010101

• Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

  The Cochrane database of systematic reviews 20010101

• Multiple system atrophy: pathophysiology and management.

  CNS drugs 20010101

• The pathogenesis of ALS: implications for treatment strategies.

  Neurologia i neurochirurgia polska 20010101

• Pharmacological treatment of ALS.

  Neurologia i neurochirurgia polska 20010101

• [Symptomatic treatment and palliative care of ALS].

  Neurologia i neurochirurgia polska 20010101

• The clinical effectiveness and cost-effectiveness of riluzole for motor neurone disease: a rapid and systematic review.

  Health technology assessment (Winchester, England) 20010101

• The role of glutamatergic transmission in the pathogenesis of levodopa-induced dyskinesias. Potential therapeutic approaches.

  Neurologia i neurochirurgia polska 20010101

• The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.

  Molecular pharmacology 20000501

• Blood pressure elevations in riluzole-treated patients with amyotrophic lateral sclerosis.

  European neurology 20000101

• Riluzole for levodopa-induced dyskinesias in advanced Parkinson's disease.

  Lancet (London, England) 19990522

• Riluzole improves functional recovery after ischemia in the rat retina.

  Investigative ophthalmology & visual science 19990301

• Acute hepatitis after riluzole administration.

  Journal of hepatology 19990301

• Antioxidative and proapoptotic effects of riluzole on cultured cortical neurons.

  Journal of neurochemistry 19990201

• Renal tubular impairment during riluzole therapy.

  Neurology 19990201

• Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

  The Journal of pharmacology and experimental therapeutics 19970801

• Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.

  Annals of neurology 19960201