1745-07-9 | 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$9.00	$7.00
5g	98%	in stock	$43.00	$31.00
10g	98%	in stock	$67.00	$47.00
25g	98%	in stock	$157.00	$110.00

Description

• Catalog Number: AA92742
• Chemical Name: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS Number: 1745-07-9
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.2423
• MDL Number: MFCD00777849
• SMILES: COc1cc2CNCCc2cc1OC

Computed Properties

• Complexity: 186
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 1.3

Literature

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  Journal of molecular neuroscience : MN 20120101

• Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012

• Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.

  European journal of medicinal chemistry 20110901

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

  The European journal of neuroscience 20090801

• Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a 'funny' if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs.

  Drug metabolism and disposition: the biological fate of chemicals 20090701

• Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.

  ChemMedChem 20090201

• 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.

  Journal of medicinal chemistry 20081211

• 4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.

  Bioorganic & medicinal chemistry 20080401

• Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.

  Bioorganic & medicinal chemistry 20080101

• In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450.

  Bioorganic & medicinal chemistry 20061201

• 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.

  Archiv der Pharmazie 20060701

• In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase.

  Bioscience, biotechnology, and biochemistry 20040401

• The chromatographic data in QSAR assay of TIQs derivatives with beta2-adrenergic activity.

  Acta poloniae pharmaceutica 20040101

• N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

  Bioorganic & medicinal chemistry letters 20031215

• Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.

  The Journal of biological chemistry 20020104