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Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.
British journal of pharmacology 20150101
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Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Circulation research 20120803
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Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.
American journal of physiology. Gastrointestinal and liver physiology 20120701
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The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.
The Journal of physiology 20120615
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Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.
Endocrinology 20120301
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Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.
The Journal of biological chemistry 20120106
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Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.
PloS one 20120101
-
Calcium-sensing receptor modulates cell adhesion and migration via integrins.
The Journal of biological chemistry 20111125
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Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis.
Kidney international 20110901
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Calcimimetics inhibit renal pathology in rodent nephronophthisis.
Kidney international 20110901
-
Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
The Journal of pharmacology and experimental therapeutics 20110601
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Effects of calcimimetic combined with an angiotensin-converting enzyme inhibitor on uremic cardiomyopathy progression.
American journal of nephrology 20110101
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Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptor.
Journal of molecular endocrinology 20101001
-
Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention.
The Journal of biological chemistry 20100625
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Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis.
Anatomical record (Hoboken, N.J. : 2007) 20100501
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Functional expression of the extracellular-Ca2+-sensing receptor in mouse taste cells.
Journal of cell science 20100315
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Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.
Calcified tissue international 20100301
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Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
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Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.
The Journal of pharmacology and experimental therapeutics 20091201
-
Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.
Journal of medicinal chemistry 20091112
-
Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat.
Journal of hypertension 20091001
-
Human PTH gene regulation in vivo using transgenic mice.
American journal of physiology. Renal physiology 20090901
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R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801
-
The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice.
Atherosclerosis 20090701
-
Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats.
Pediatric nephrology (Berlin, Germany) 20090701
-
The corpuscles of Stannius, calcium-sensing receptor, and stanniocalcin: responses to calcimimetics and physiological challenges.
Endocrinology 20090701
-
Calcimimetic inhibits late-stage cyst growth in ADPKD.
Journal of the American Society of Nephrology : JASN 20090701
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Type II calcimimetics and polycystic kidney disease: unanswered questions.
Journal of the American Society of Nephrology : JASN 20090701
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Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic.
Laboratory investigation; a journal of technical methods and pathology 20090501
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Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD.
American journal of physiology. Renal physiology 20090401
-
Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090201
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Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.
Cardiovascular research 20090201
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The new role of calcimimetics as vasculotropic agents.
Kidney international 20090101
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A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia.
Kidney international 20090101
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Calcimimetics normalize the phosphate-induced stimulation of PTH secretion in vivo and in vitro.
Journal of nephrology 20090101
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The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells.
Journal of experimental & clinical cancer research : CR 20090101
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[Calcimimetic or calcitriol? A new class struggle].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20090101
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Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.
The Journal of physiology 20081215
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The extracellular Ca2+-sensing receptor branches out--a new role in lung morphogenesis.
The Journal of physiology 20081215
-
Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors.
The Journal of clinical endocrinology and metabolism 20081201
-
Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats.
American journal of physiology. Renal physiology 20080401
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N-isopropylsulfinylimines as useful intermediates in the synthesis of chiral amines: expeditive asymmetric synthesis of the calcimimetic (+)-NPS R-568.
The Journal of organic chemistry 20080118
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Destabilization of parathyroid hormone mRNA by extracellular Ca2+ and the calcimimetic R-568 in parathyroid cells: role of cytosolic Ca and requirement for gene transcription.
Journal of molecular endocrinology 20080101
-
CKD-MBD: impact on management of kidney disease.
Clinical and experimental nephrology 20071201
-
Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells.
Biochemical and biophysical research communications 20071012
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The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands.
American journal of physiology. Renal physiology 20070501
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Calcium sensing receptor activators: calcimimetics.
Current medicinal chemistry 20070101
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Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols.
Calcified tissue international 20061201
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Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.
The Journal of endocrinology 20060901
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[Calcium receptor/calcium-sensing receptor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901
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Meta-analysis of biochemical and patient-level effects of calcimimetic therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 20060501
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Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism.
Pharmacology & therapeutics 20060301
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Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats.
Journal of the American Society of Nephrology : JASN 20060301
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Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol.
Journal of the American Society of Nephrology : JASN 20060301
-
Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.
Journal of the American Society of Nephrology : JASN 20060101
-
Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency.
Pharmacological reports : PR 20060101
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Role of calcium-phosphorous disorders in the progression of renal failure.
Kidney international. Supplement 20051201
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Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).
The Journal of biological chemistry 20051104
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[Calcimimetics, mechanisms of action and therapeutic applications].
Presse medicale (Paris, France : 1983) 20050910
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[Apoptosis: a possible mechanism of suppressing parathyroid hyperplasia by calcimimetics].
Clinical calcium 20050901
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[Management of secondary hyperparathyroidism].
Clinical calcium 20050901
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Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease.
Kidney international. Supplement 20050601
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[Calcimimetics--a new treatment for hyperparathyroidism?].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050501
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Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics.
Journal of pharmacological sciences 20050301
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Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats.
American journal of hypertension 20050301
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Calcimimetics and the treatment of primary and secondary hyperparathyroidism.
The Annals of pharmacotherapy 20041101
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Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.
Journal of the American Society of Nephrology : JASN 20041001
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Calcimimetics and hyperparathyroidism.
Current opinion in investigational drugs (London, England : 2000) 20041001
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Calcimimetic agents for the treatment of secondary hyperparathyroidism.
Seminars in nephrology 20040901
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Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands.
The Journal of organic chemistry 20040820
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Modulation and action of the calcium-sensing receptor.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040801
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A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040501
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Calcimimetic and calcilytic drugs: just for parathyroid cells?
Cell calcium 20040301
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[Bone status in primary hyperparathyroidism].
Nihon rinsho. Japanese journal of clinical medicine 20040201
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Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.
Pediatric nephrology (Berlin, Germany) 20031201
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Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031001
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Calcimimetic agents: review and perspectives.
Kidney international. Supplement 20030601
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Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors.
Journal of the American Society of Nephrology : JASN 20030401
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[Calcimimetic agents in the treatment of hyperparathyroidism secondary to chronic renal failure].
Medicina 20030101
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[Calcimimmetic and calcilytics: new perspectives of correction of abnormal parathormone (PTH) secretion].
Przeglad lekarski 20030101
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Calcium sensing receptor activation by a calcimimetic suggests a link between cooperativity and intracellular calcium oscillations.
The Journal of biological chemistry 20021220
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Calcimimetics: therapeutic potential in hyperparathyroidism.
Current opinion in pharmacology 20021201
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Calcimimetics in the treatment of primary hyperparathyroidism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101
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Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor.
European journal of pharmacology 20020705
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Future role of calcimimetics in end-stage renal disease.
Advances in renal replacement therapy 20020701
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Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor.
The Journal of biological chemistry 20020524
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[Bone changes in primary hyperparathyroidism].
Nihon rinsho. Japanese journal of clinical medicine 20020301
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Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020201
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Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020101
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Criteria for calcimimetic agent in the treatment of more severe secondary hyperparathyroidism.
Kidney international 20010101
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Prevention of uremic bone disease using calcimimetic compounds.
Annual review of medicine 20010101
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Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
Endocrinology 20001101
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Calcimimetics with potent and selective activity on the parathyroid calcium receptor.
Proceedings of the National Academy of Sciences of the United States of America 19980331
