17766-28-8 | 1-Cyclohexylpiperazine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$12.00	$8.00
5g	98%	in stock	$20.00	$14.00
10g	98%	in stock	$30.00	$21.00
25g	98%	in stock	$69.00	$49.00
100g	98%	in stock	$200.00	$140.00

Description

• Catalog Number: AB00183
• Chemical Name: 1-Cyclohexylpiperazine
• CAS Number: 17766-28-8
• Molecular Formula: C10H20N2
• Molecular Weight: 168.2792
• MDL Number: MFCD03434391
• SMILES: C1CCC(CC1)N1CCNCC1

Computed Properties

• Complexity: 124
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 1.4

Literature

• 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity.

  ChemMedChem 20110103

• Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.

  Magnetic resonance in chemistry : MRC 20100101

• Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

  Journal of medicinal chemistry 20091210

• 1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review.

  Central nervous system agents in medicinal chemistry 20090901

• Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.

  ChemMedChem 20090201

• Preparation of 99mTc-nitrido asymmetrical heterocomplex with 4-(cyclohexylpiperazin-1-yl)-dithioformate and its biological evaluation as a potential myocardial imaging agent.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20071001

• Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.

  Molecular cancer therapeutics 20060701

• Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET.

  The Journal of pharmacy and pharmacology 20051101

• Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors.

  Bioorganic & medicinal chemistry 20050601

• New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'.

  Journal of medicinal chemistry 20040826

• 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.

  Journal of medicinal chemistry 20040422