177834-92-3 | Eletriptan hydrobromide

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$70.00	$49.00
250mg	98%	in stock	$114.00	$80.00
1g	98%	in stock	$259.00	$181.00
5g	98%	in stock	$931.00	$652.00

Description

• Catalog Number: AB00349
• Chemical Name: Eletriptan hydrobromide
• CAS Number: 177834-92-3
• Molecular Formula: C22H27BrN2O2S
• Molecular Weight: 463.43098
• MDL Number: MFCD08141806
• SMILES: CN1CCC[C@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1.Br

Computed Properties

• Complexity: 582
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6

Literature

• Quantitative analysis of eletriptan in human plasma by HPLC-MS/MS and its application to pharmacokinetic study.

  Analytical and bioanalytical chemistry 20111101

• Efficacy, safety, and tolerability of sertraline on depressive symptoms in women with comorbid migraine: an open-label study.

  Journal of clinical psychopharmacology 20110601

• BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study.

  Cephalalgia : an international journal of headache 20110401

• Cluster headache following dental treatment: a case report.

  Journal of oral science 20110301

• Drug dependence associated with triptans and ergot derivatives: a case/non-case study.

  European journal of clinical pharmacology 20100401

• Perimenstrual eletriptan prevents menstrual migraine: an open-label study.

  Headache 20100401

• Real-life experiences in migraine therapy.

  Bratislavske lekarske listy 20100101

• A case of ocular hypertension complicated by SUNCT syndrome.

  Annals of ophthalmology (Skokie, Ill.) 20100101

• Eletriptan.

  Expert opinion on drug metabolism & toxicology 20091201

• Study of forced degradation behavior of eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method.

  Journal of pharmaceutical and biomedical analysis 20091101

• Large-scale screening and subsequent effects of migraine treatment on the work floor in the Netherlands.

  Cephalalgia : an international journal of headache 20090601

• Treatment of sinus headache as migraine: the diagnostic utility of triptans.

  The Laryngoscope 20081201

• Halide salts of antimigraine agents eletriptan and naratriptan.

  Acta crystallographica. Section C, Crystal structure communications 20081201

• Triptans: actions and reactions.

  Headache 20080401

• Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database.

  Headache 20080201

• Identification of negative predictors of pain-free response to triptans: analysis of the eletriptan database.

  Cephalalgia : an international journal of headache 20080101

• Patient satisfaction with eletriptan in the acute treatment of migraine in primary care.

  International journal of clinical practice 20071001

• Efficacy of eletriptan in migraine-related functional impairment: functional and work productivity outcomes.

  Headache 20070501

• Eletriptan for the acute treatment of migraine in adolescents: results of a double-blind, placebo-controlled trial.

  Headache 20070401

• Comment on eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

  Headache 20070301

• Efficacy of eletriptan in triptan-naïve patients: results of a combined analysis.

  Headache 20070201

• Eletriptan: a review and new perspectives.

  Expert review of neurotherapeutics 20061001

• Comparative sensitivity of stopwatch methodology and conventional pain assessment measures for detecting early response to triptans in migraine: results of a randomized, open-label pilot study.

  Clinical therapeutics 20060801

• [Triptanes in the treatment of migraine. A review based on three Cochrane reviews].

  Ugeskrift for laeger 20060508

• Does earlier headache response equate to earlier return to functioning in patients suffering from migraine?

  Cephalalgia : an international journal of headache 20060401

• Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine.

  Cephalalgia : an international journal of headache 20060301

• [Medical treatment of migraine attacks in the child].

  Revue de l'infirmiere 20060101

• Safety and efficacy of eletriptan in the treatment of acute migraine.

  Pharmacotherapy 20060101

• Eletriptan: a review of its use in the acute treatment of migraine.

  Drugs 20060101

• Eletriptan in migraine patients reporting unsatisfactory response to rizatriptan.

  Headache 20060101

• Spotlight on eletriptan in migraine.

  CNS drugs 20060101

• Effects of sumatriptan and eletriptan on diseased epicardial coronary arteries.

  European journal of clinical pharmacology 20051101

• Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.

  Clinical science (London, England : 1979) 20050901

• Therapeutic benefit of eletriptan compared to sumatriptan for the acute relief of migraine pain--results of a model-based meta-analysis that accounts for encapsulation.

  Cephalalgia : an international journal of headache 20050901

• Eletriptan treatment of migraine in patients switching from barbiturate-containing analgesics: results from a multiple-attack study.

  Cephalalgia : an international journal of headache 20050901

• Eletriptan in the early treatment of acute migraine: influence of pain intensity and time of dosing.

  Cephalalgia : an international journal of headache 20050901

• Multiple attack study on the available triptans in Italy versus placebo.

  European journal of neurology 20050701

• Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.

  Journal of managed care pharmacy : JMCP 20050601

• Eletriptan review.

  Expert opinion on pharmacotherapy 20050401

• Patient preference for eletriptan 80 mg versus subcutaneous sumatriptan 6 mg: results of a crossover study in patients who have recently used subcutaneous sumatriptan.

  European journal of neurology 20050201

• pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis.

  Electrophoresis 20050201

• Eletriptan in migraine.

  Expert review of neurotherapeutics 20050101

• Which is more elusive, the pot of gold at the end of a rainbow or determining the most cost-effective triptan?

  Journal of managed care pharmacy : JMCP 20050101

• [Probabilistic cost-effectiveness analysis of oral eletriptan in the treatment of acute migraine in Portugal].

  Acta medica portuguesa 20050101

• No effect of eletriptan administration during the aura phase of migraine.

  European journal of neurology 20041001

• [Spanish contribution to the clinical development of eletriptan: an analysis of controlled studies].

  Neurologia (Barcelona, Spain) 20041001

• TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management.

  Acta neurologica Scandinavica 20040901

• [Triptans in migraine: a comparative review of pharmacology, pharmacokinetics].

  No to shinkei = Brain and nerve 20040901

• [Triptans in migraine: from clinical view].

  No to shinkei = Brain and nerve 20040901

• [Meta-analysis of triptan treatment in migraine].

  No to shinkei = Brain and nerve 20040901

• [Side effects of triptans].

  No to shinkei = Brain and nerve 20040901

• Meta-analysis of oral triptans.

  Cephalalgia : an international journal of headache 20040801

• Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.

  Naunyn-Schmiedeberg's archives of pharmacology 20040701

• Cardiovascular safety of triptans.

  Cephalalgia : an international journal of headache 20040701

• Effect of high-dose intravenous eletriptan on coronary artery diameter.

  Cephalalgia : an international journal of headache 20040701

• Migraine headache.

  Clinical evidence 20040601

• Double-blind clinical trials of oral triptans vs other classes of acute migraine medication - a review.

  Cephalalgia : an international journal of headache 20040501

• Eletriptan for the short-term prophylaxis of cluster headache.

  Headache 20040401

• Effectiveness of eletriptan in acute migraine: primary care for Excedrin nonresponders.

  Headache 20040301

• Eletriptan for the acute treatment of migraine: results of bridging a Japanese study to Western clinical trials.

  Current medical research and opinion 20040301

• The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat.

  Brain research 20040213

• [Use of triptanes according to indications. Risk of infarct is not increased].

  MMW Fortschritte der Medizin 20040212

• [Recent progress in therapy for migraine headache].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040210

• The 40-mg dose of eletriptan: comparative efficacy and tolerability versus sumatriptan 100 mg.

  European journal of neurology 20040201

• New drugs 04, part 1.

  Nursing 20040201

• Comparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine.

  Cephalalgia : an international journal of headache 20031201

• Migraine headache.

  Clinical evidence 20031201

• Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine.

  Cephalalgia : an international journal of headache 20031101

• Tolerability and safety of eletriptan in the treatment of migraine: a comprehensive review.

  Headache 20031001

• Efficacy of eletriptan in migraineurs with persistent poor response to nonsteroidal anti-inflammatory drugs.

  Headache 20031001

• Unilateral time-delayed encapsulation does not make for a fair race.

  Headache 20030901

• Encapsulated sumatriptan is not bioequivalent to commercial sumatriptan.

  Headache 20030901

• Musing on Mathew et al.

  Headache 20030901

• [Strong and sustained-acting triptan. Therewith migraine does not return soon].

  MMW Fortschritte der Medizin 20030807

• Eletriptan for the treatment of migraine in patients with previous poor response or tolerance to oral sumatriptan.

  Cephalalgia : an international journal of headache 20030701

• Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.

  Drug metabolism and disposition: the biological fate of chemicals 20030701

• [Pharmacological, pharmacokinetic and clinical profile of eletriptan (Relpax), a new triptan for migraine].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030701

• The evolving management of migraine.

  Current opinion in neurology 20030601

• [Improved pharmacokinetics. Fast tryptan with sustained response].

  MMW Fortschritte der Medizin 20030526

• [Highly selective beginning. Associated symptoms and side effects in retrospect].

  MMW Fortschritte der Medizin 20030526

• Eletriptan (relpax) for migraine.

  The Medical letter on drugs and therapeutics 20030428

• Eletriptan vs sumatriptan: a double-blind, placebo-controlled, multiple migraine attack study.

  Neurology 20030408

• Efficacy, safety, and tolerability of oral eletriptan for treatment of acute migraine: a multicenter, double-blind, placebo-controlled study conducted in the United States.

  Headache 20030301

• Comparative efficacy of eletriptan 40 mg versus sumatriptan 100 mg.

  Headache 20030301

• Cost-effectiveness of migraine treatment: a commentary.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20030101

• A cost-effectiveness analysis of eletriptan 40 and 80 mg versus sumatriptan 50 and 100 mg in the acute treatment of migraine.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20030101

• Eletriptan issues.

  Headache 20030101

• Sumatriptan versus eletriptan: which is best?

  The Lancet. Neurology 20021201

• Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate.

  Brain research 20021025

• Eletriptan vs sumatriptan: a double-blind, placebo-controlled, multiple migraine attack study.

  Neurology 20021022

• New medications show promise for migraine sufferers.

  Dentistry today 20021001

• Eletriptan Pfizer.

  Current opinion in investigational drugs (London, England : 2000) 20020901

• Mechanisms of action of the 5-HT1B/1D receptor agonists.

  Archives of neurology 20020701

• Efficacy and safety of eletriptan 20 mg, 40 mg and 80 mg in Japanese migraineurs.

  Cephalalgia : an international journal of headache 20020701

• The pharmacokinetics and safety of single escalating oral doses of eletriptan.

  Journal of clinical pharmacology 20020501

• Pharmacokinetics, pharmacodynamics, and safety of the 5-HT(1B/1D) agonist eletriptan following intravenous and oral administration.

  Journal of clinical pharmacology 20020501

• [Migraine has to be treated. Otherwise a stroke threatens].

  MMW Fortschritte der Medizin 20020214

• Efficacy, safety and tolerability of oral eletriptan in the acute treatment of migraine: results of a phase III, multicentre, placebo-controlled study across three attacks.

  Cephalalgia : an international journal of headache 20020201

• [New triptanes in control of migraine attacks. More rapid onset of action--more efficient reduction of pain].

  MMW Fortschritte der Medizin 20020124

• Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison.

  European neurology 20020101

• Pharmacokinetics and safety of oral eletriptan during different phases of the menstrual cycle in healthy volunteers.

  Journal of clinical pharmacology 20011201

• Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.

  Lancet (London, England) 20011117

• Eletriptan.

  Expert opinion on investigational drugs 20011001

• Triptans are all different.

  Archives of neurology 20010901

• Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.

  European journal of pharmacology 20010817

• Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels.

  Neurology 20010710

• [New potent serotonin receptor agonist. Helps migraine patients even when other triptans fail].

  MMW Fortschritte der Medizin 20010705

• Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).

  Archives of neurology 20010701

• Pharmacology and efficacy of eletriptan for the treatment of migraine attacks.

  International journal of clinical practice 20010601

• [Eletriptan shortly before drug approval. Fewer problems in migraine therapy].

  MMW Fortschritte der Medizin 20010528

• Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model.

  Microscopy research and technique 20010501

• [Current topics: expectation for new triptans].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410

• Acute treatment of migraine and the role of triptans.

  Current neurology and neuroscience reports 20010301

• pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.

  Electrophoresis 20010101

• Eletriptan for acute migraine.

  The Cochrane database of systematic reviews 20010101

• Eletriptan: pharmacological differences and clinical results.

  Current medical research and opinion 20010101

• Comparative aspects of triptans in treating migraine.

  Clinical cornerstone 20010101

• Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.

  Acta neurologica Belgica 19990601

• Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.

  European journal of pharmacology 19990305