1852-17-1 | Tetrahydro-2(1h)-pyrimidinone

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$22.00	$15.00
5g	95%	in stock	$25.00	$17.00
10g	95%	in stock	$36.00	$25.00
25g	95%	in stock	$57.00	$40.00
100g	95%	in stock	$153.00	$107.00
500g	95%	in stock	$572.00	$400.00

Description

• Catalog Number: AB79540
• Chemical Name: Tetrahydro-2(1h)-pyrimidinone
• CAS Number: 1852-17-1
• Molecular Formula: C4H8N2O
• Molecular Weight: 100.11912
• MDL Number: MFCD00014593
• SMILES: O=C1NCCCN1
• NSC Number: 21315

Computed Properties

• Complexity: 73.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 2
• XLogP3: -1.3

Literature

• Voltammetric oxidation of 2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxamides: substituent effects.

  The journal of physical chemistry. A 20110728

• Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

  Journal of medicinal chemistry 20110714

• Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition.

  Organic & biomolecular chemistry 20110507

• Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1-phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: a stereochemical perspective from endo and exocyclic chiral centres.

  Organic & biomolecular chemistry 20101107

• Stereodivergent synthesis of 1,3-syn- and -anti-tetrahydropyrimidinones.

  Organic letters 20101015

• Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.

  The journal of physical chemistry. A 20100902

• Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20100701

• 4,5,8a-Triphenyl-perhydro-pyrimido[4,5-d]pyrimidine-2,7-dione monohydrate.

  Acta crystallographica. Section E, Structure reports online 20100601

• Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.

  Journal of medicinal chemistry 20100513

• A novel multicomponent synthesis of polyfunctionalized bicyclic tetrahydropyrimidinone derivatives via mercaptoacetylative ring transformations.

  Carbohydrate research 20091123

• 1-Benzoyl-5-phenyl-2-(propan-2-yl)-1,2,3,4-tetra-hydro-pyrimidin-4-one.

  Acta crystallographica. Section E, Structure reports online 20091001

• 2-Phenyl-tetrahydropyrimidine-4(1H)-ones--cyclic benzaldehyde aminals as precursors for functionalised beta-amino acids.

  Beilstein journal of organic chemistry 20090101

• 4-Phenyl-1,2,3,4-tetra-hydro-pyrimido[1,2-a]benzimidazol-2-one.

  Acta crystallographica. Section E, Structure reports online 20081101

• Synthesis and immunosuppressive activity evaluation of substituted N-imidazolidin-2-ones and N-tetrahydropyrimidin-2(1H)-ones.

  Journal of enzyme inhibition and medicinal chemistry 20081001

• Low-temperature redetermination of 3,4,5,6-tetra-hydro-pyrimidin-2(1H)-one.

  Acta crystallographica. Section E, Structure reports online 20080501

• Phenanthroline-derived ratiometric chemosensor for ureas.

  The Journal of organic chemistry 20070330

• Tunable capsule space: self-assembly of hemispherical cavitands with hydrogen-bonding linkers.

  The Journal of organic chemistry 20061110

• Icilin activates the delta-subunit of the human epithelial Na+ channel.

  Molecular pharmacology 20051001

• Hydrophobicity in the design of P2/P2' tetrahydropyrimidinone HIV protease inhibitors.

  Bioorganic & medicinal chemistry letters 20050815

• Topological models for the prediction of HIV-protease inhibitory activity of tetrahydropyrimidin-2-ones.

  Journal of molecular graphics & modelling 20050101

• A simple clustering technique to improve QSAR model selection and predictivity: application to a receptor independent 4D-QSAR analysis of cyclic urea derived inhibitors of HIV-1 protease.

  Journal of chemical information and computer sciences 20030101