1867-73-8 | N6-Methyladenosine

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$15.00	$10.00
100mg	97%	in stock	$18.00	$12.00
250mg	97%	in stock	$22.00	$15.00
1g	97%	in stock	$52.00	$36.00
5g	97%	in stock	$219.00	$153.00
10g	97%	in stock	$333.00	$233.00
25g	97%	in stock	$760.00	$532.00

Description

• Catalog Number: AD62909
• Chemical Name: N6-Methyladenosine
• CAS Number: 1867-73-8
• Molecular Formula: C11H15N5O4
• Molecular Weight: 281.2679
• MDL Number: MFCD00005739
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC

Computed Properties

• Complexity: 349
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3
• XLogP3: -0.4

Literature

• N(6)-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.

  Toxicology letters 20180801

• m(6)A modulates haematopoietic stem and progenitor cell specification.

  Nature 20170914

• MicroRNA-145 Modulates N(6)-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N(6)-Methyladenosine Binding YTH Domain Family 2 Protein.

  The Journal of biological chemistry 20170303

• Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

  Nature 20120429

• Control of substrate specificity by a single active site residue of the KsgA methyltransferase.

  Biochemistry 20120110

• N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

  Nature chemical biology 20111201

• The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods.

  Analytical and bioanalytical chemistry 20111001

• Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.

  Journal of medicinal chemistry 20110825

• Use of a QM/MM-based FEP method to evaluate the anomalous hydration behavior of simple alkyl amines and amides: application to the design of FBPase inhibitors for the treatment of type-2 diabetes.

  Journal of the American Chemical Society 20110601

• Site-directed mutants of 16S rRNA reveal important RNA domains for KsgA function and 30S subunit assembly.

  Biochemistry 20110208

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC).

  RNA (New York, N.Y.) 20090601

• Anticodon domain modifications contribute order to tRNA for ribosome-mediated codon binding.

  Biochemistry 20080610

• MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor.

  The Plant cell 20080501

• Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control.

  British journal of cancer 20060605

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.

  Journal of medicinal chemistry 20050728

• (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

  Journal of medicinal chemistry 20050324

• Synthesis of oligoribonucleotides containing N6-alkyladenosine and 2-methylthio-N6-alkyladenosine.

  Current protocols in nucleic acid chemistry 20040901

• Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design.

  Journal of the American Chemical Society 20030910

• Characterization of the cAMP binding site of purified S-adenosyl-homocysteine hydrolase from bovine kidney.

  Biochemical pharmacology 20021015

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Differentiation-dependent repression of c-myc, B22, COX II and COX IV genes in murine erythroleukemia (MEL) cells.

  Biochemical pharmacology 20020301

• Chondrocytes respond to adenosine via A(2)receptors and activity is potentiated by an adenosine deaminase inhibitor and a phosphodiesterase inhibitor.

  Osteoarthritis and cartilage 20020101

• Transcriptional activation of prion protein gene in growth-arrested and differentiated mouse erythroleukemia and human neoplastic cells.

  Experimental cell research 20010401

• Cloning, sequencing and expression of a cDNA encoding the mouse L35a ribosomal protein during differentiation of murine erythroleukemia (MEL) cells.

  Cell biology international 20010101

• Ribosome structure: localization of N6,N6-dimethyladenosine by electron microscopy of a ribosome-antibody complex.

  Proceedings of the National Academy of Sciences of the United States of America 19770401