187164-19-8 | 2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$11.00	$8.00
50mg	98%	in stock	$13.00	$9.00
100mg	98%	in stock	$16.00	$11.00
250mg	98%	in stock	$26.00	$18.00
1g	98%	in stock	$55.00	$39.00
5g	98%	in stock	$108.00	$76.00
25g	98%	in stock	$378.00	$265.00

Description

• Catalog Number: AB75253
• Chemical Name: 2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
• CAS Number: 187164-19-8
• Molecular Formula: C14H9Cl2N3S2
• Molecular Weight: 354.2774
• MDL Number: MFCD00953915
• SMILES: N#C/C(=C1/SC[C@H](S1)c1ccc(cc1Cl)Cl)/n1cncc1

Computed Properties

• Complexity: 476
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• XLogP3: 4

Literature

• Antimycotics suppress the Malassezia extract-induced production of CXC chemokine ligand 10 in human keratinocytes.

  The Journal of dermatology 20140201

• Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes.

  Journal of dermatological science 20130901

• Childhood tinea incognito caused by Trichophyton mentagrophytes var. interdigitale mimicking pustular psoriasis.

  Pediatric dermatology 20110101

• Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model.

  Medical mycology 20100501

• In vitro antifungal activities of luliconazole, a new topical imidazole.

  Medical mycology 20090101

• [Fungicidal activity of liranaftate against dermatophytes].

  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

• Allergic contact dermatitis from luliconazole.

  Contact dermatitis 20070501

• Allergic contact dermatitis from luliconazole: implication of the dithioacetal structure.

  Acta dermato-venereologica 20070101

• [Pharmacological and clinical properties of luliconazole (Lulicon Cream 1%, Lulicon Solution 1%), a novel topical antifungal agent].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501

• In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040801

• In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species.

  International journal of antimicrobial agents 20030301

• Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis.

  Microbiology and immunology 20030101

• Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections.

  International journal of antimicrobial agents 19990801

• In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.

  Antimicrobial agents and chemotherapy 19980401