18740-38-0 | Thieno[2,3-d]pyrimidine-2,4-diol

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$34.00	$24.00
5g	97%	in stock	$99.00	$70.00

Description

• Catalog Number: AB79657
• Chemical Name: Thieno[2,3-d]pyrimidine-2,4-diol
• CAS Number: 18740-38-0
• Molecular Formula: C6H4N2O2S
• Molecular Weight: 168.1732
• MDL Number: MFCD16495868
• SMILES: Oc1nc(O)c2c(n1)scc2

Computed Properties

• Complexity: 219
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• XLogP3: 0.5

Literature

• Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.

  Journal of medicinal chemistry 20110728

• Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.

  Bioorganic & medicinal chemistry letters 20031020

• Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.

  Journal of medicinal chemistry 20030102