188343-77-3 | Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$108.00	$75.00
5mg	95%	in stock	$260.00	$182.00
10mg	95%	in stock	$342.00	$239.00

Description

• Catalog Number: AB14942
• Chemical Name: Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-
• CAS Number: 188343-77-3
• Molecular Formula: C21H22FN3
• Molecular Weight: 335.4179
• MDL Number: MFCD30474871
• SMILES: CN1CCC(CC1)c1[nH]c(c(c1)c1ccncc1)c1ccc(cc1)F

Computed Properties

• Complexity: 409
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.6

Literature

• A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.

  Science (New York, N.Y.) 20100514

• Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase.

  Molecular and biochemical parasitology 20060901

• Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.

  Journal of natural products 20060401

• Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor.

  Molecular and biochemical parasitology 20060301

• Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.

  Bioorganic & medicinal chemistry letters 20050701

• Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.

  Journal of natural products 20050401

• A role for coccidian cGMP-dependent protein kinase in motility and invasion.

  International journal for parasitology 20040309

• Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.

  Eukaryotic cell 20020601

• Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target.

  The Journal of biological chemistry 20020503