191217-81-9 | Pramipexole DiHCl monohydrate

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$29.00	$20.00
1g	97%	in stock	$42.00	$30.00
5g	97%	in stock	$82.00	$57.00
25g	97%	in stock	$209.00	$146.00

Description

• Catalog Number: AB12732
• Chemical Name: Pramipexole DiHCl monohydrate
• CAS Number: 191217-81-9
• Molecular Formula: C10H20ClN3OS
• Molecular Weight: 265.8033000000001
• MDL Number: MFCD00876894
• SMILES: CCCN[C@H]1CCc2c(C1)sc(n2)N.Cl.O

Computed Properties

• Complexity: 188
• Covalently-Bonded Unit Count: 4
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 3

Literature

• ADMET considerations for restless leg syndrome drug treatments.

  Expert opinion on drug metabolism & toxicology 20121001

• The role of the dopaminergic system in mood, motivation and cognition in Parkinson's disease: a double blind randomized placebo-controlled experimental challenge with pramipexole and methylphenidate.

  Journal of the neurological sciences 20120915

• Pramipexole-related chronic lower limb oedema in a patient with Parkinson's disease.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20120901

• Spontaneous unwelcome orgasms due to pramipexole and ropinirole.

  Movement disorders : official journal of the Movement Disorder Society 20120901

• The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.

  Sleep 20120801

• Pramipexole- and methamphetamine-induced reward-mediated behavior in a rodent model of Parkinson's disease and controls.

  Behavioural brain research 20120715

• Indirect comparisons of adverse events and dropout rates in early Parkinson's disease trials of pramipexole, ropinirole, and rasagiline.

  The International journal of neuroscience 20120701

• Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120601

• Effects of acute pramipexole on male rats' preference for gambling-like rewards II.

  Experimental and clinical psychopharmacology 20120601

• Reversible antecollis associated with pramipexole in a patient with Parkinson's disease.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20120601

• Finasteride attenuates pathological gambling in patients with Parkinson disease.

  Journal of clinical psychopharmacology 20120601

• Dopamine dysregulation syndrome including mania related to coadministration of droxidopa.

  Journal of clinical psychopharmacology 20120601

• Dissociation of periodic leg movements from arousals in restless legs syndrome.

  Annals of neurology 20120601

• Anhedonia in Japanese patients with Parkinson's disease: analysis using the Snaith-Hamilton Pleasure Scale.

  Clinical neurology and neurosurgery 20120501

• Pramipexole-induced increased probabilistic discounting: comparison between a rodent model of Parkinson's disease and controls.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120501

• Leg movements during wakefulness in restless legs syndrome: time structure and relationships with periodic leg movements during sleep.

  Sleep medicine 20120501

• Dopamine agonist-induced penile erection and yawning: differential role of D₂-like receptor subtypes and correlation with nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats.

  Behavioural brain research 20120501

• A multicenter randomized placebo-controlled clinical trial of pramipexole for Tourette's syndrome.

  Movement disorders : official journal of the Movement Disorder Society 20120501

• [Othello syndrome induced by pramipexole].

  Revista de neurologia 20120416

• Photo-degradation products of pramipexole.

  Bioorganic & medicinal chemistry letters 20120415

• An upper limb variant of RLS? Report of 2 cases.

  Clinical neurology and neurosurgery 20120401

• In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120401

• Burning mouth syndrome in Parkinson's disease: dopamine as cure or cause?

  The journal of headache and pain 20120401

• Dopamine agonists in dihydropteridine reductase deficiency.

  Molecular genetics and metabolism 20120401

• Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain.

  Journal of psychiatry & neuroscience : JPN 20120301

• Evaluation of periodic limb movements in a putative animal model of restless leg syndrome.

  Movement disorders : official journal of the Movement Disorder Society 20120301

• CART peptide in the nucleus accumbens shell acts downstream to dopamine and mediates the reward and reinforcement actions of morphine.

  Neuropharmacology 20120301

• The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity.

  Neurobiology of disease 20120301

• Novel extraction technique to remove a penile constriction device.

  The journal of sexual medicine 20120301

• Effectiveness of pramipexole, a dopamine agonist, on rapid eye movement sleep behavior disorder.

  The Tohoku journal of experimental medicine 20120301

• Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice.

  European journal of pharmacology 20120227

• Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats.

  Brain research 20120209

• Breakthrough symptoms during the daytime in patients with restless legs syndrome (Willis-Ekbom disease).

  Sleep medicine 20120201

• Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats.

  Psychopharmacology 20120101

• Effect of pramipexole on cutaneous-silent-period parameters in patients with restless legs syndrome.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20120101

• Dopamine agonist use and the risk of heart failure.

  Pharmacoepidemiology and drug safety 20120101

• Efficacy and safety of pramipexole in chinese patients with restless legs syndrome: results from a multi-center, randomized, double-blind, placebo-controlled trial.

  Sleep medicine 20120101

• Placebo-controlled adjunctive trial of pramipexole in patients with bipolar disorder: targeting cognitive dysfunction.

  The Journal of clinical psychiatry 20120101

• Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas.

  Clinical schizophrenia & related psychoses 20120101

• Pramipexole may be an effective treatment option in essential tremor.

  Clinical neuropharmacology 20120101

• Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease.

  Clinical interventions in aging 20120101

• Efficacy and safety of extended- versus immediate-release pramipexole in Japanese patients with advanced and L-dopa-undertreated Parkinson disease: a double-blind, randomized trial.

  Clinical neuropharmacology 20120101

• The efficacy of pramipexole, a dopamine receptor agonist, as an adjunctive treatment in treatment-resistant depression: an open-label trial.

  TheScientificWorldJournal 20120101

• Pramipexole upregulates dopamine receptor D₂ and D₃ expression in rat striatum.

  Journal of pharmacological sciences 20120101

• Temporal stability of the Unified Dyskinesia Rating Scale.

  Movement disorders : official journal of the Movement Disorder Society 20111201

• New dopamine agonist pramipexole improves parkinsonism and depression in Parkinson's disease.

  Hiroshima journal of medical sciences 20111201

• The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis.

  Nature medicine 20111120

• Effect of chronic kidney disease on excessive daytime sleepiness in Parkinson disease.

  European journal of neurology 20111101

• Development and validation of a chiral capillary electrophoresis method for assay and enantiomeric purity control of pramipexole.

  Journal of separation science 20111101

• Restless legs syndrome in subjects with a knee prosthesis: evidence that symptoms are generated in the periphery.

  Clinics (Sao Paulo, Brazil) 20111101

• Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist.

  Biological psychiatry 20111015

• Dopamine D1/5 and D2/3 agonists differentially attenuate somatic signs of nicotine withdrawal in rats.

  Pharmacology, biochemistry, and behavior 20111001

• Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats.

  Pharmacology, biochemistry, and behavior 20111001

• Pharmacokinetic evaluation of pramipexole.

  Expert opinion on drug metabolism & toxicology 20111001

• Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.

  Behavioural pharmacology 20111001

• Acupuncture for restless legs syndrome in patients previously treated with dopaminergic drugs.

  Acupuncture in medicine : journal of the British Medical Acupuncture Society 20110901

• Pramipexole extended release in Parkinson's disease.

  Expert review of neurotherapeutics 20110901

• Extended-release pramipexole in advanced Parkinson disease: a randomized controlled trial.

  Neurology 20110823

• Extended-release pramipexole in early Parkinson disease: a 33-week randomized controlled trial.

  Neurology 20110823

• Executive control in Parkinson's disease: effects of dopaminergic medication and deep brain stimulation on anti-cue keypress performance.

  Neuroscience letters 20110815

• Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects.

  Journal of clinical pharmacology 20110801

• Pathological gambling plus hypersexuality in restless legs syndrome: a new case.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20110801

• Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease.

  Physiology & behavior 20110725

• Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome.

  Neurology 20110712

• Pramipexole for the treatment of early Parkinson's disease.

  Expert review of neurotherapeutics 20110701

• Treatment-resistant sensory motor symptoms in persons with SCI may be signs of restless legs syndrome.

  Spinal cord 20110601

• Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine D3 and D2 receptor sensitivity.

  Psychopharmacology 20110601

• Alterations in pain responses in treated and untreated patients with restless legs syndrome: associations with sleep disruption.

  Sleep medicine 20110601

• Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression.

  The international journal of neuropsychopharmacology 20110501

• A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome.

  Sleep medicine 20110501

• Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype.

  Neuropharmacology 20110501

• Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies.

  Parkinsonism & related disorders 20110501

• Pramipexole modulates the neural network of reward anticipation.

  Human brain mapping 20110501

• Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample.

  Sleep medicine 20110501

• Development and validation of GC/MS method for determination of pramipexole in rat plasma.

  Biomedical chromatography : BMC 20110401

• Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment.

  Psychopharmacology 20110401

• The first case of a 'jumping stump' syndrome in a lower limb amputee responding to pramipexole.

  European journal of neurology 20110401

• Efficacy and augmentation during 6 months of double-blind pramipexole for restless legs syndrome.

  Sleep medicine 20110401

• Adjunctive treatment with low-dosage pramipexole for risperidone-associated hyperprolactinemia and sexual dysfunction in a male patient with schizophrenia.

  Journal of clinical psychopharmacology 20110401

• Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome.

  Movement disorders : official journal of the Movement Disorder Society 20110401

• Tinnitus control by dopamine agonist pramipexole in presbycusis patients: a randomized, placebo-controlled, double-blind study.

  The Laryngoscope 20110401

• [Adverse effect of Sifrol or not?].

  Lakartidningen 20110401

• Dopamine agonists for restless legs syndrome.

  The Cochrane database of systematic reviews 20110316

• Pharmacotherapy for the treatment of acute bipolar II depression: current evidence.

  The Journal of clinical psychiatry 20110301

• Drugs and drug delivery in PD: optimizing control of symptoms with pramipexole prolonged-release.

  European journal of neurology 20110301

• Treatment of depressive symptoms in Parkinson's disease.

  European journal of neurology 20110301

• Hemiparkinsonism-hemiatrophy syndrome.

  Archives of Iranian medicine 20110301

• The effect of pramipexole on depressive symptoms in Parkinson's disease.

  The Kobe journal of medical sciences 20110202

• Evaluation of painful sensory symptoms in restless legs syndrome: experience from two clinical trials.

  Sleep medicine 20110201

• Cost effectiveness of rasagiline and pramipexole as treatment strategies in early Parkinson's disease in the UK setting: An economic Markov model evaluation.

  Drugs & aging 20110201

• Effects of acute pramipexole on preference for gambling-like schedules of reinforcement in rats.

  Psychopharmacology 20110101

• Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep.

  Sleep medicine 20110101

• Twice-daily, low-dose pramipexole in early Parkinson's disease: a randomized, placebo-controlled trial.

  Movement disorders : official journal of the Movement Disorder Society 20110101

• Randomized trial of pramipexole for patients with restless legs syndrome (RLS) and RLS-related impairment of mood.

  Sleep medicine 20110101

• The long-term effects of the dopamine agonist pramipexole in a proposed restless legs syndrome animal model.

  Sleep medicine 20110101

• Efficacy, safety and dose-response of pramipexole in Japanese patients with primary restless legs syndrome: randomized trial.

  Neuropsychobiology 20110101

• Pathological gambling in a bipolar patient treated with pramipexole.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Increased plasma arginine vasopressin levels in dopamine agonist-treated Parkinson's disease patients.

  Neuro endocrinology letters 20110101

• Binding of pramipexole to extrastriatal dopamine D2/D3 receptors in the human brain: a positron emission tomography study using 11C-FLB 457.

  PloS one 20110101

• Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands.

  Neuropharmacology 20110101

• Panic attack-like episodes possibly induced by pramipexole in a patient with young-onset Parkinson's disease.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease.

  Internal medicine (Tokyo, Japan) 20110101

• Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease.

  Pharmacological reports : PR 20110101

• Pramipexole versus dual release levodopa in restless legs syndrome: a double blind, randomised, cross-over trial.

  Swiss medical weekly 20110101

• Pramipexole-induced peripheral edema in a patient with bipolar depression.

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Exercise dependence induced by pramipexole in Parkinson's Disease-a case report.

  Movement disorders : official journal of the Movement Disorder Society 20101215

• Stability studies and structural characterization of pramipexole.

  Journal of pharmaceutical and biomedical analysis 20101201

• Levodopa and pramipexole effects on presynaptic dopamine PET markers and estimated dopamine release.

  European journal of nuclear medicine and molecular imaging 20101201

• Pramipexole for stage 2 treatment-resistant major depression: an open study.

  Progress in neuro-psychopharmacology & biological psychiatry 20101201

• Dopamine agonists and Othello's syndrome.

  Parkinsonism & related disorders 20101201

• Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis.

  IDrugs : the investigational drugs journal 20101201

• Randomized, double-blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20101115

• Validated ultra-performance liquid chromatography tandem mass spectrometry method for the determination of pramipexole in human plasma.

  Journal of chromatographic science 20101101

• Efficacy, safety, and tolerability of overnight switching from immediate- to once daily extended-release pramipexole in early Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20101030

• Toxicity assessment of pramipexole in juvenile rhesus monkeys.

  Toxicology 20101029

• Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease.

  Neurochemical research 20101001

• Role of pramipexole in the management of Parkinson's disease.

  CNS drugs 20101001

• Differential pharmacological responses of catatonia-like signs in frontotemporal dementia.

  Neurocase 20101001

• [Dopaminergic neuroprotection and reconstruction of neural network tiara].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001

• Clozapine for medication-related pathological gambling in Parkinson disease.

  Movement disorders : official journal of the Movement Disorder Society 20100915

• Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review.

  The Psychiatric quarterly 20100901

• Isolated delusional syndrome in Parkinson's Disease.

  Parkinsonism & related disorders 20100901

• Pramipexole extended-release (once-daily formulation) for the treatment of Parkinson's disease.

  Expert opinion on pharmacotherapy 20100901

• Recurrence of cluster headache with pramipexole.

  Acta neurologica Belgica 20100901

• Rationale for delayed-start study of pramipexole in Parkinson's disease: the PROUD study.

  Movement disorders : official journal of the Movement Disorder Society 20100815

• Uptake of pramipexole by human organic cation transporters.

  Molecular pharmaceutics 20100802

• Long-term open-label study of pramipexole in patients with primary restless legs syndrome.

  Journal of the neurological sciences 20100715

• Continuous dopaminergic stimulation by pramipexole is effective to treat early morning akinesia in animal models of Parkinson's disease: A pharmacokinetic-pharmacodynamic study using in vivo microdialysis in rats.

  Synapse (New York, N.Y.) 20100701

• Bipolar disorder: an update.

  Postgraduate medicine 20100701

• Dual motor response to l-dopa and nociceptin/orphanin FQ receptor antagonists in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) treated mice: Paradoxical inhibition is relieved by D(2)/D(3) receptor blockade.

  Experimental neurology 20100601

• Parametric approaches towards understanding the effects of the preferential D3 receptor agonist pramipexole on prepulse inhibition in rats.

  Pharmacology, biochemistry, and behavior 20100601

• Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial.

  The Lancet. Neurology 20100601

• Pramipexole for depression and motor symptoms in Parkinson's disease: can we kill two birds with one stone?

  The Lancet. Neurology 20100601

• Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.

  Archives of general psychiatry 20100601

• Effects of pramipexole on impulsive choice in male wistar rats.

  Experimental and clinical psychopharmacology 20100601

• Acute dopamine-agonist treatment in restless legs syndrome: effects on sleep architecture and NREM sleep instability.

  Sleep 20100601

• [Clinical studies on pramipexol retard].

  Ideggyogyaszati szemle 20100530

• Dopaminergic challenges in social anxiety disorder: evidence for dopamine D3 desensitisation following successful treatment with serotonergic antidepressants.

  Journal of psychopharmacology (Oxford, England) 20100501

• Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.

  Archives of neurology 20100501

• Proposed dose equivalence between clonazepam and pramipexole in patients with restless legs syndrome.

  Progress in neuro-psychopharmacology & biological psychiatry 20100416

• Dopamine agonist induced compulsive eating behaviour in a Parkinson's disease patient.

  Pharmacy world & science : PWS 20100401

• Impulsive smoking in a patient with Parkinson's disease treated with dopamine agonists.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100401

• Pramipexole extended release: in Parkinson's disease.

  CNS drugs 20100401

• [Pathologic gambling as an adverse effect of the treatment for Parkinson's disease].

  Revista medica de Chile 20100401

• Compulsive habits in restless legs syndrome patients under dopaminergic treatment.

  Journal of the neurological sciences 20100315

• Patent watch.

  Nature reviews. Drug discovery 20100301

• [Clinical data of the prolonged-release formulation of ropinirole].

  Fortschritte der Neurologie-Psychiatrie 20100301

• The effects of pramipexole on prepulse inhibition and locomotor activity in C57BL/6J mice.

  Behavioural pharmacology 20100301

• Use of the D2/D3 receptor agonist pramipexole in treatment of rapid-cycling bipolar disorder in an elderly patient.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20100301

• Pramipexole combined with levodopa improves motor function but reduces dyskinesia in MPTP-treated common marmosets.

  Movement disorders : official journal of the Movement Disorder Society 20100215

• Best practice guide for the treatment of REM sleep behavior disorder (RBD).

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20100215

• Successful treatment of restless legs syndrome with the herbal prescription Yokukansan.

  Progress in neuro-psychopharmacology & biological psychiatry 20100201

• Population in vitro-in vivo correlation model for pramipexole slow-release oral formulations.

  Pharmaceutical research 20100201

• Zolpidem-induced sleep-related eating disorder.

  Journal of the neurological sciences 20100115

• Changes of cortical excitability after dopaminergic treatment in restless legs syndrome.

  Sleep medicine 20100101

• Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects.

  Clinical neuropharmacology 20100101

• Efficacy and safety of pramipexole in Japanese patients with primary restless legs syndrome: A polysomnographic randomized, double-blind, placebo-controlled study.

  Sleep medicine 20100101

• Why do some promising brain-stimulation devices fail the next steps of clinical development?

  Expert review of medical devices 20100101

• Effects of a dopamine agonist on the pharmacodynamics of levodopa in Parkinson disease.

  Archives of neurology 20100101

• Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study.

  Sleep 20100101

• Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole.

  BMC pharmacology 20100101

• Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data.

  The Journal of neuropsychiatry and clinical neurosciences 20100101

• [Effect of dopamine agonist pramipexole (mirapex) on tremor, affective disorders and quality of life in patients with Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Delusion of Cotard's syndrome successfully treated with a dopamine agonist.

  The Journal of neuropsychiatry and clinical neurosciences 20100101

• Impact of dopamine agonists on compulsive behaviors: a case series of pramipexole-induced pathological gambling.

  Psychosomatics 20100101

• [Effects of the dopamine agonist mirapex (pramipexole) therapy on sleep disorders in Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Validation of a column liquid chromatographic method for the analysis of pramipexole and its five impurities.

  Journal of AOAC International 20100101

• Dopaminergic treatment in idiopathic restless legs syndrome: effects on subjective sleepiness.

  Clinical neuropharmacology 20100101

• Nonmotor symptoms in de novo Parkinson disease before and after dopaminergic treatment.

  Journal of the neurological sciences 20091215

• Pramipexole and gender identity disorder: expanding the phenotype of hypersexuality in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20091215

• Neuroprotective effects of pramipexole against tunicamycin-induced cell death in PC12 cells.

  Clinical and experimental pharmacology & physiology 20091201

• Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.

  Neurochemistry international 20091201

• Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.

  European journal of clinical pharmacology 20091201

• Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson's disease?

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091201

• Potential neuroprotection mechanisms in PD: focus on dopamine agonist pramipexole.

  Current medical research and opinion 20091201

• Neuroprotective effect of L-dopa on dopaminergic neurons is comparable to pramipexol in MPTP-treated animal model of Parkinson's disease: a direct comparison study.

  Journal of neurochemistry 20091101

• Pharmacokinetics of a once-daily extended-release formulation of pramipexole in healthy male volunteers: three studies.

  Clinical therapeutics 20091101

• An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20091030

• Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model.

  Experimental neurology 20091001

• Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS.

  Journal of clinical pharmacy and therapeutics 20091001

• Managing pathological gambling in Parkinson's disease with enteral levodopa/carbidopa infusions.

  Movement disorders : official journal of the Movement Disorder Society 20090915

• Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia.

  Journal of gambling studies 20090901

• Long-term retention rate of pramipexole in the treatment of Parkinson's disease.

  European journal of clinical pharmacology 20090901

• Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients.

  Brain : a journal of neurology 20090901

• Pramipexole effects on startle gating in rats and normal men.

  Psychopharmacology 20090901

• Dopamine agonists in 6-pyruvoyl tetrahydropterin synthase deficiency.

  Neurology 20090825

• Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats.

  European journal of pharmacology 20090815

• Disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive Holmes' tremor.

  Journal of neurology, neurosurgery, and psychiatry 20090801

• Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44.

  Pharmacology, biochemistry, and behavior 20090801

• Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function.

  Human brain mapping 20090701

• Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20090701

• Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson's disease patients.

  European journal of clinical pharmacology 20090701

• A dose-ranging study of pramipexole for the symptomatic treatment of restless legs syndrome: polysomnographic evaluation of periodic leg movements and sleep disturbance.

  Sleep medicine 20090601

• Overnight switching from ergot-derived dopamine agonists to pramipexole in patients with Parkinson's disease: an open preliminary trial in Japan.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090601

• The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.

  Archives of general psychiatry 20090601

• Pramipexole induced compulsive behaviors abate after initiation of rotigitine.

  Movement disorders : official journal of the Movement Disorder Society 20090515

• [Socioeconomic relevance of the idiopathic restless legs syndrome (RLS) in Germany: cost-of-illness study].

  Medizinische Klinik (Munich, Germany : 1983) 20090515

• Changes in artistic style and behaviour in Parkinson's disease: dopamine and creativity.

  Journal of neurology 20090501

• Long-term effect of initiating pramipexole vs levodopa in early Parkinson disease.

  Archives of neurology 20090501

• A case of compulsive behaviors observed in a restless legs syndrome patient treated with a dopamine agonist.

  Sleep 20090501

• Treatment of sleep disorders after traumatic brain injury.

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20090415

• Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: a case report.

  The journal of sexual medicine 20090401

• The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats.

  Psychopharmacology 20090401

• Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.

  The Journal of pharmacology and experimental therapeutics 20090401

• Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease.

  Mayo Clinic proceedings 20090401

• Effects of a dopamine receptor agonist and atropine sulfate on absorption of valproic acid in rats.

  Biomedical research (Tokyo, Japan) 20090401

• Dopamine and cognitive functioning in de novo subjects with Parkinson's disease: effects of pramipexole and pergolide on working memory.

  Neuropsychologia 20090401

• Antiparkinsonian drug-induced sleepiness: a double-blind placebo-controlled study of L-dopa, bromocriptine and pramipexole in healthy subjects.

  British journal of clinical pharmacology 20090301

• Treatment options for restless legs syndrome.

  Expert opinion on pharmacotherapy 20090301

• Reversible Pisa syndrome in patients with Parkinson's disease on dopaminergic therapy.

  Journal of neurology 20090301

• Sustained administration of pramipexole modifies the spontaneous firing of dopamine, norepinephrine, and serotonin neurons in the rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201

• Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: application to a clinical pharmacokinetic study.

  Biomedical chromatography : BMC 20090201

• High risk factors for valvular heart disease from dopamine agonists in patients with Parkinson's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 20090201

• Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report.

  European journal of neurology 20090201

• [Impulse control disorder induced by the use of dopamine agonists].

  Nederlands tijdschrift voor geneeskunde 20090117

• Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.

  Movement disorders : official journal of the Movement Disorder Society 20090115

• [Pathological gambling induced by dopamine agonist].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090110

• The effect of pramipexole on mood and motivational symptoms in Parkinson's disease: a meta-analysis of placebo-controlled studies.

  Clinical therapeutics 20090101

• [The role of low-dose pramipexole in the treatment of treatment-resistant bipolar depression: a case report].

  Turk psikiyatri dergisi = Turkish journal of psychiatry 20090101

• Cost effectiveness of rasagiline and pramipexole as treatment strategies in early Parkinson's disease in the UK setting: an economic Markov model evaluation.

  Drugs & aging 20090101

• [Influence of dopamine agonist pramipexole (mirapex) on tremor, cognitive and affective impairment in patients with Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Restless legs syndrome: differential diagnosis and management with pramipexole.

  Clinical interventions in aging 20090101

• [Fatigability in Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Cabergoline and pramipexole fail to modify already established dyskinesias in an animal model of parkinsonism.

  Behavioural brain research 20081201

• Effect of pramipexole on RLS symptoms and sleep: a randomized, double-blind, placebo-controlled trial.

  Sleep medicine 20081201

• Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells.

  European journal of pharmacology 20081119

• Hiccups and dopamine.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081115

• [D3 agonism: an augmentative treatment in tardive dyskinesia? A case report].

  Psychiatrische Praxis 20081101

• Late onset dopa-responsive dystonia with tremor, gait freezing and behavioural disturbance and a normal dopamine transporter scan.

  Age and ageing 20081101

• [Restless-leg syndrome--possible unrecognized cause for insomnia and irritability in children].

  No to hattatsu = Brain and development 20081101

• Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.

  Journal of medicinal chemistry 20081009

• Meta-analysis of the efficacy and tolerability of pramipexole versus ropinirole in the treatment of restless legs syndrome.

  Sleep medicine 20081001

• Discontinuation of ropinirole and pramipexole in patients with Parkinson's disease: clinical practice versus clinical trials.

  European journal of clinical pharmacology 20081001

• Heart valve abnormalities in Parkinson's disease treated with dopamine agonists.

  Journal of neurology 20081001

• Cost-effectiveness of licensed treatment options for restless legs syndrome in the UK and Sweden.

  Current medical research and opinion 20081001

• Lack of effects of pramipexole on REM sleep behavior disorder in Parkinson disease.

  Sleep 20081001

• Analysis of the anti-Parkinson drug pramipexole in human urine by capillary electrophoresis with laser-induced fluorescence detection.

  Analytica chimica acta 20080919

• Defining the boundaries of the response of sleep leg movements to a single dose of dopamine agonist.

  Sleep 20080901

• Unraveling depression in Parkinson's disease.

  European journal of neurology 20080901

• Dopaminergic modulation of semantic priming in Parkinson disease.

  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20080901

• [Pathological gambling and Parkinson disease].

  Brain and nerve = Shinkei kenkyu no shinpo 20080901

• [Case of a 30-year history of PARK6 --findings from functional imaging of the brain].

  Rinsho shinkeigaku = Clinical neurology 20080901

• Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.

  Neuroscience letters 20080801

• Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response.

  Experimental neurology 20080801

• Open-label study of the long-term efficacy and safety of pramipexole in patients with Restless Legs Syndrome (extension of the PRELUDE study).

  Sleep medicine 20080701

• Internal medicine: guidance to the diagnosis and management of restless legs syndrome.

  Southern medical journal 20080601

• Restless legs syndrome in women: a review.

  Journal of women's health (2002) 20080601

• A 77-year-old man with Parkinson's disease and hyperthermia.

  Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20080601

• Fatal intoxication using amantadine and pramipexole in a uremic patient.

  Acta neurologica Taiwanica 20080601

• The frequency of cardiac valvular regurgitation in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20080515

• Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.

  The Journal of pharmacology and experimental therapeutics 20080501

• Medications used to treat Parkinson's disease and the risk of gambling.

  European journal of neurology 20080401

• Pramipexole-induced psychosis in Parkinson's disease.

  Psychiatry and clinical neurosciences 20080401

• Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter.

  European journal of pharmacology 20080317

• [Isolated pulmonary hypertension and pergolide].

  Revue neurologique 20080301

• Restless arms.

  Lancet (London, England) 20080209

• Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness.

  Psychopharmacology 20080201

• Restless legs syndrome in older adults.

  Clinics in geriatric medicine 20080201

• Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers.

  Journal of clinical psychopharmacology 20080201

• Burning mouth syndrome responsive to pramipexol.

  The journal of headache and pain 20080201

• Clinical experience with pramipexole in the treatment of restless legs syndrome.

  Expert opinion on drug metabolism & toxicology 20080201

• R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALS.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20080201

• Pramipexole-induced antecollis in Parkinson's disease.

  Journal of the neurological sciences 20080115

• [Pramipexole and Parkinson's disease, an update].

  Revista de neurologia 20080101

• Pramipexole safely replaces ergot dopamine agonists with either rapid or slow switching.

  The Journal of international medical research 20080101

• Conversion from dopamine agonists to cabergoline: an open-label trial in 128 patients with advanced Parkinson disease.

  Clinical neuropharmacology 20080101

• Development and evaluation of push-pull based osmotic delivery system for pramipexole.

  PDA journal of pharmaceutical science and technology 20080101

• Dopamine agonist increases risk taking but blunts reward-related brain activity.

  PloS one 20080101

• [Mirapex (pramipexole) in the treatment of non-motor disturbances in Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis.

  CNS neuroscience & therapeutics 20080101

• [Pain and depression in Parkinson's disease: new therapeutic possibilities of pramipexole].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Pramipexole-induced dropped head syndrome in Parkinson's disease.

  Internal medicine (Tokyo, Japan) 20080101

• Reversible dopamine agonist induced anterocollis in a multiple system atrophy patient.

  Movement disorders : official journal of the Movement Disorder Society 20071115

• Comparison of pramipexole with and without domperidone co-administration on alertness, autonomic, and endocrine functions in healthy volunteers.

  British journal of clinical pharmacology 20071101

• Quantification of pramipexole in human plasma by liquid chromatography tandem mass spectrometry using tamsulosin as internal standard.

  Biomedical chromatography : BMC 20071101

• Rapid eye movement sleep behavior disorder.

  The Annals of pharmacotherapy 20071101

• [Sleep disorder as alarm symptom].

  MMW Fortschritte der Medizin 20071025

• Dopaminergic agonists: possible neurorescue drugs endowed with independent and synergistic multisites of action.

  Neurochemical research 20071001

• Restless legs syndrome: nonpharmacologic and pharmacologic treatments.

  Geriatrics 20071001

• Pramipexole prevents neurotoxicity induced by oligomers of beta-amyloid.

  European journal of pharmacology 20070827

• Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease.

  Parkinsonism & related disorders 20070801

• First night efficacy of pramipexole in restless legs syndrome and periodic leg movements.

  Sleep medicine 20070801

• Pramipexole in psychiatry: a systematic review of the literature.

  The Journal of clinical psychiatry 20070801

• Impact of pramipexole on the onset of levodopa-related dyskinesias.

  Movement disorders : official journal of the Movement Disorder Society 20070715

• Risk factors for somnolence, edema, and hallucinations in early Parkinson disease.

  Neurology 20070710

• Dopamine agonists and cardiac valvulopathy in Parkinson disease: a case-control study.

  Neurology 20070703

• Use of the dopamine receptor agonist Mirapex in the treatment of Parkinson's disease.

  Neuroscience and behavioral physiology 20070701

• Orthostatic tremor in progressive supranuclear palsy.

  Movement disorders : official journal of the Movement Disorder Society 20070615

• Risk factors for the development of pedal edema in patients using pramipexole.

  Archives of neurology 20070601

• Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial.

  The Lancet. Neurology 20070601

• Efficacy and safety of pramipexole in restless legs syndrome.

  Neurology 20070508

• Panic attack like episodes possibly associated with pramipexole therapy in Parkinson's disease.

  European journal of neurology 20070501

• Belly dancer's syndrome following central pontine and extrapontine myelinolysis.

  Movement disorders : official journal of the Movement Disorder Society 20070430

• Blood-brain barrier transport of pramipexole, a dopamine D2 agonist.

  Life sciences 20070403

• Responsiveness to a dopamine agent in Holmes tremor--case report.

  European journal of neurology 20070401

• Pramipexole (Mirapex) for restless legs syndrome.

  The Medical letter on drugs and therapeutics 20070326

• Cardiac valve regurgitation with pergolide compared with nonergot agonists in Parkinson disease.

  Archives of neurology 20070301

• Treatment of juvenile Parkinson disease and the recurrent emergence of pathologic gambling.

  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20070301

• Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.

  European journal of pharmacology 20070227

• A case of mania following the use of pramipexole.

  The American journal of psychiatry 20070201

• [Pramipexole therapy of restless legs syndrome].

  Ideggyogyaszati szemle 20070120

• Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: a reader-blinded monocenter echocardiography study.

  Movement disorders : official journal of the Movement Disorder Society 20070115

• Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-RLS study).

  Movement disorders : official journal of the Movement Disorder Society 20070115

• Restless arm symptoms as an extension of restless leg syndrome.

  Age and ageing 20070101

• Drug adverse events and drop-out risk: a clinical case.

  Archives of gerontology and geriatrics 20070101

• Pramipexole in levodopa-treated Parkinson disease patients of African, Asian, and Hispanic heritage.

  Clinical neuropharmacology 20070101

• Pramipexole: in restless legs syndrome.

  CNS drugs 20070101

• The implications of using US-specific EQ-5D preference weights for cost-effectiveness evaluation.

  Medical decision making : an international journal of the Society for Medical Decision Making 20070101

• The effect of levodopa and dopamine agonists on optic nerve head in Parkinson disease.

  European journal of ophthalmology 20070101

• [Dopamine agonists in the treatment of motor complications in advanced Parkinson's disease].

  Neurologia i neurochirurgia polska 20070101

• In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability.

  The Journal of pharmacology and experimental therapeutics 20061201

• Long-term treatment with pramipexole in restless legs syndrome.

  European journal of neurology 20061201

• Neuroprotection in Parkinson models varies with toxin administration protocol.

  The European journal of neuroscience 20061201

• Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child.

  Journal of child neurology 20061201

• Factors associated with the development of motor fluctuations and dyskinesias in Parkinson disease.

  Archives of neurology 20061201

• End-of-dose deterioration in non ergolinic dopamine agonist monotherapy of Parkinson's disease.

  Journal of neurology 20061201

• Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers.

  Journal of psychopharmacology (Oxford, England) 20061101

• Increase in body weight after pramipexole treatment in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20061101

• Telogen effluvium associated with the dopamine agonist pramipexole in a 55-year-old woman with Parkinson's disease.

  Journal of the American Academy of Dermatology 20061101

• A dopamine agonist, pramipexole, and cognitive functions in Parkinson's disease.

  Journal of the neurological sciences 20061025

• Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease.

  Journal of the neurological sciences 20061025

• Dopamine agonist therapy in low-response children following traumatic brain injury.

  Journal of child neurology 20061001

• Efficacy and safety of pramipexole in restless legs syndrome.

  Neurology 20060926

• Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome.

  Movement disorders : official journal of the Movement Disorder Society 20060901

• Comparison of pramipexole and amisulpride on alertness, autonomic and endocrine functions in healthy volunteers.

  Psychopharmacology 20060901

• New-onset narcolepsy with cataplexy in a geriatric patient.

  Sleep medicine 20060901

• [Pathological gambling associated with pramipexole use in Parkinson's disease].

  Revista de neurologia 20060901

• [Treatment of Parkinson disease: therapeutic reserve of the dopaminergic agonist].

  Neurologia (Barcelona, Spain) 20060901

• Efficacy and safety of pramipexole in idiopathic restless legs syndrome: a polysomnographic dose-finding study--the PRELUDE study.

  Sleep medicine 20060801

• Use of pramipexole in REM sleep behavior disorder: results from a case series.

  Sleep medicine 20060801

• [Reversible pathological gambling under treatment with pramipexole].

  Der Nervenarzt 20060801

• [Dopamine agonists for treatment of restless leg syndrome].

  Medizinische Monatsschrift fur Pharmazeuten 20060801

• Association of dopamine agonist use with impulse control disorders in Parkinson disease.

  Archives of neurology 20060701

• Validated chiral liquid chromatographic method for the enantiomeric separation of Pramipexole dihydrochloride monohydrate.

  Journal of pharmaceutical and biomedical analysis 20060616

• [More on therapeutic options in fibromyalgia].

  Medicina clinica 20060610

• [Restless legs syndrome: when uncontrollable urge to move afflicts the patient...].

  MMW Fortschritte der Medizin 20060608

• Chronic cluster headache responsive to pramipexole.

  Cephalalgia : an international journal of headache 20060601

• [Pre-launching of drugs--the RLS example].

  Lakartidningen 20060601

• [Case of juvenile parkinsonism in pregnancy].

  Rinsho shinkeigaku = Clinical neurology 20060601

• Pramipexole versus sertraline in the treatment of depression in Parkinson's disease: a national multicenter parallel-group randomized study.

  Journal of neurology 20060501

• Hiccups associated with dopamine agonists in Parkinson disease.

  Neurology 20060314

• Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Pramipexole protects against MPTP toxicity in non-human primates.

  Journal of neurochemistry 20060301

• Pramipexole for the treatment of restless legs syndrome.

  Expert opinion on pharmacotherapy 20060301

• Restless legs syndrome: facts & treatments. This strange malady affects 12 million Americans, many of whom go misdiagnosed or undiagnosed.

  Health news (Waltham, Mass.) 20060301

• Pramipexole: augmentation in the treatment of depressive symptoms.

  CNS spectrums 20060301

• Gambling and Parkinson disease.

  Archives of neurology 20060201

• Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride].

  The Journal of pharmacology and experimental therapeutics 20060101

• The neurophysiology of the alternating leg muscle activation (ALMA) during sleep: study of one patient before and after treatment with pramipexole.

  Sleep medicine 20060101

• Pramipexole protects against H2O2-induced PC12 cell death.

  Naunyn-Schmiedeberg's archives of pharmacology 20060101

• Motor deficits in Parkinsonian reaching: dopa-sensitivity influenced by real-world task constraint.

  Journal of motor behavior 20060101

• Pramipexole versus levodopa in patients with early Parkinson's disease: effect on generic and disease-specific quality of life.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20060101

• Management of restless legs syndrome in patients on dialysis.

  Drugs 20060101

• Reversal learning in Parkinson's disease depends on medication status and outcome valence.

  Neuropsychologia 20060101

• [Dopamine receptors agonists (mirapex) in the treatment of Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats.

  Pharmacological reports : PR 20060101

• Using pramipexole in neuropsychiatry: a cautionary note.

  The Journal of neuropsychiatry and clinical neurosciences 20060101

• [7-year experience in usage of mirapex in patients with different forms of primary parkinsonism].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.

  Neuropsychobiology 20060101

• Optimization of chiral separation of pramipexole on various polisaccharide stationary phases.

  Acta poloniae pharmaceutica 20060101

• Changing dopamine agonist treatment in Parkinson's disease: experiences with switching to pramipexole.

  Journal of neural transmission. Supplementum 20060101

• Parkinson's drug may relieve fibromyalgia pain.

  Health news (Waltham, Mass.) 20051201

• Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment.

  Psychopharmacology 20051101

• Antiparkinson concentrations of pramipexole and PHNO occupy dopamine D2(high) and D3(high) receptors.

  Synapse (New York, N.Y.) 20051101

• Present and future drug treatment for Parkinson's disease.

  Journal of neurology, neurosurgery, and psychiatry 20051101

• Dopamine D3 receptor-preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons.

  The European journal of neuroscience 20051101

• Pathological gambling in Parkinson's disease.

  The Lancet. Neurology 20051001

• Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.

  Journal of medicinal chemistry 20050908

• Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy.

  Parkinsonism & related disorders 20050901

• Pramipexole in the treatment of Parkinson's disease: new developments.

  Expert review of neurotherapeutics 20050901

• A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications.

  Arthritis and rheumatism 20050801

• Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.

  Archives of neurology 20050801

• Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.

  Neurological research 20050701

• A pilot double-blind placebo-controlled trial of low-dose pramipexole in sleep-related eating disorder.

  European journal of neurology 20050601

• Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial.

  Movement disorders : official journal of the Movement Disorder Society 20050501

• Actometry in measuring the symptom severity of restless legs syndrome.

  European journal of neurology 20050501

• Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004.

  Movement disorders : official journal of the Movement Disorder Society 20050501

• Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.

  Drug metabolism and disposition: the biological fate of chemicals 20050401

• Pramipexole, ropinirole, and mania in Parkinson's disease.

  The American journal of psychiatry 20050401

• Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection.

  Neuroscience letters 20050329

• 'Levodopa phobia': a new iatrogenic cause of disability in Parkinson disease.

  Neurology 20050308

• Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence.

  Addiction (Abingdon, England) 20050301

• Sleep attacks in patients receiving dopamine-receptor agonists.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050301

• Recovery from parkinson syndrome and prolonged visually evoked potentials in hepatic encephalopathy.

  Metabolic brain disease 20050301

• Molecular studies probe bipolar disorder.

  JAMA 20050202

• A randomly assigned double-blind cross-over study examining the relative anti-parkinsonian tremor effects of pramipexole and pergolide.

  European journal of neurology 20050101

• Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole.

  The Journal of neuropsychiatry and clinical neurosciences 20050101

• [Syndrome of inappropriate ADH secretion (SIADH) induced by pramipexole in a patient with Parkinson's disease].

  Nihon Jinzo Gakkai shi 20050101

• Pramipexole and levodopa in early Parkinson's disease: dynamic changes in cost effectiveness.

  PharmacoEconomics 20050101

• Short review on dopamine agonists: insight into clinical and research studies relevant to Parkinson's disease.

  Pharmacological reports : PR 20050101

• Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms.

  Journal of neurochemistry 20041201

• [Pramipexole for intractable hiccups].

  Medicina clinica 20041113

• Switching from ergot to nonergot dopamine agonists in Parkinson's disease: a clinical series and five-drug dose conversion table.

  Movement disorders : official journal of the Movement Disorder Society 20041101

• Predictors of sudden onset of sleep in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20041101

• Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells.

  Experimental neurology 20041101

• Periodic leg movements in prepubertal children with sleep disturbance.

  Developmental medicine and child neurology 20041101

• Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20041001

• The activity of pramipexole in the mouse forced swim test is mediated by D2 rather than D3 receptors.

  Psychopharmacology 20040901

• Pramipexole-treated Parkinson's disease during pregnancy.

  Movement disorders : official journal of the Movement Disorder Society 20040901

• The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia.

  Pharmacology, biochemistry, and behavior 20040801

• Calming restless legs.

  Sleep 20040801

• Pramipexole for bipolar II depression: a placebo-controlled proof of concept study.

  Biological psychiatry 20040701

• Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial.

  Archives of neurology 20040701

• [Pharmacological profiles and clinical effects of antiparkinsonian agent, pramipexole].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040601

• Pramipexole for the treatment of uremic restless legs in patients undergoing hemodialysis.

  Neurology 20040309

• Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression.

  The American journal of psychiatry 20040301

• Conversion from dopamine agonists to pramipexole. An open-label trial in 227 patients with advanced Parkinson's disease.

  Journal of neurology 20040301

• Slowing Parkinson's disease progression: recent dopamine agonist trials.

  Neurology 20040127

• Slowing Parkinson's disease progression: recent dopamine agonist trials.

  Neurology 20040127

• Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS).

  Sleep medicine 20040101

• Predictors of impaired daytime sleep and wakefulness in patients with Parkinson disease treated with older (ergot) vs newer (nonergot) dopamine agonists.

  Archives of neurology 20040101

• Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuations.

  Movement disorders : official journal of the Movement Disorder Society 20040101

• [A comparative study of efficacy of dopamine receptors agonists and catechol-O-methyltransferase in the treatment of late stages of Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

• Low-dose pramipexole in the management of restless legs syndrome. An open label trial.

  Neuropsychobiology 20040101

• Restless legs symptoms in a patient with above knee amputations: a case of phantom restless legs.

  Clinical neuropharmacology 20040101

• Pramipexole v. levodopa as initial treatment for Parkinson's disease: a randomized clinical-economic trial.

  Medical decision making : an international journal of the Society for Medical Decision Making 20040101

• Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.

  BMC biology 20040101

• Pramipexole in treatment-resistant depression: an extended follow-up.

  Depression and anxiety 20040101

• Vasculitis and nephritis caused by pramipexole, a second generation dopamine agonist.

  Clinical and experimental rheumatology 20040101

• Efficacy, safety, and tolerability of pramipexole in untreated and levodopa-treated patients with Parkinson's disease.

  Journal of the neurological sciences 20031215

• Pramipexole in Restless Legs syndrome. Evaluation by suggested immobilization test.

  Journal of neurology 20031201

• Fibromyalgia and pramipexole: promise and precaution.

  The Journal of rheumatology 20031201

• The effects of pramipexole in REM sleep behavior disorder.

  Neurology 20031125

• Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole.

  Journal of neurochemistry 20031101

• Neuroprotective effects of the novel D3/D2 receptor agonist and antiparkinson agent, S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a comparison to ropinirole.

  Experimental neurology 20031101

• Randomized, double-blind, 3-month parallel study of the effects of pramipexole, pergolide, and placebo on Parkinsonian tremor.

  Movement disorders : official journal of the Movement Disorder Society 20031101

• Pramipexole in the management of restless legs syndrome: an extended study.

  Sleep 20031101

• Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20031001

• Oral anticoagulation for ECG tremor artefact simulating atrial fibrillation.

  Acta cardiologica 20031001

• Clinical strategies to prevent and delay motor complications.

  Neurology 20030923

• Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole.

  Experimental neurology 20030901

• Pramipexole inhibits MPTP toxicity in mice by dopamine D3 receptor dependent and independent mechanisms.

  European journal of pharmacology 20030815

• Pathological gambling associated with dopamine agonist therapy in Parkinson's disease.

  Neurology 20030812

• Pramipexole increases vesicular dopamine uptake: implications for treatment of Parkinson's neurodegeneration.

  European journal of pharmacology 20030808

• REAL and CALM: what have we learned?

  Movement disorders : official journal of the Movement Disorder Society 20030701

• Pramipexole and pergolide in the treatment of depression in Parkinson's disease: a national multicentre prospective randomized study.

  European journal of neurology 20030701

• The use of dopamine enhancing medications with children in low response states following brain injury.

  Brain injury 20030601

• Dopamine agonist therapy for hyperprolactinemia.

  Clinical obstetrics and gynecology 20030601

• [Treatment of restless legs syndrome in uremic patients undergoing dialysis with pramipexole: preliminary results].

  Revista medica de Chile 20030601

• Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment.

  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20030601

• The initial drug treatment of older patients with Parkinson's disease - consider an agonist, but don't demonise dopa.

  Age and ageing 20030501

• Pramipexole in comparison to l-dopa: a neuropsychological study.

  Journal of neural transmission (Vienna, Austria : 1996) 20030401

• [(123)I]beta-CIT SPECT is a useful method for monitoring dopaminergic degeneration in early stage Parkinson's disease.

  Journal of neurology, neurosurgery, and psychiatry 20030301

• Double-blind, single-dose, cross-over study of the effects of pramipexole, pergolide, and placebo on rest tremor and UPDRS part III in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20030201

• Sleep attacks--facts and fiction: a critical review.

  Advances in neurology 20030101

• Sleepwalking and sleep terrors in prepubertal children: what triggers them?

  Pediatrics 20030101

• Loss of color vision during long-term treatment with pramipexole.

  Journal of neurology 20030101

• Multiple blood donations associated with iron deficiency in patients with restless legs syndrome.

  Mayo Clinic proceedings 20030101

• Comparison of the risk of adverse events with pramipexole and ropinirole in patients with Parkinson's disease: a meta-analysis.

  Drug safety 20030101

• Cabergoline, pramipexole and ropinirole used as monotherapy in early Parkinson's disease: an evidence-based comparison.

  Drugs & aging 20030101

• Pramipexole in routine clinical practice: a prospective observational trial in Parkinson's disease.

  CNS drugs 20030101

• Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics.

  Neurology 20021224

• Dopamine agonist monotherapy in Parkinson's disease.

  Lancet (London, England) 20021130

• Dopamine agonists and neuroprotection in Parkinson's disease.

  European journal of neurology 20021101

• Do dopamine agonists or levodopa modify Parkinson's disease progression?

  European journal of neurology 20021101

• Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

• Potential antidepressant properties of pramipexole detected in locomotor and operant behavioral investigations in mice.

  Psychopharmacology 20021001

• Pramipexole in treatment-resistant depression: a 16-week naturalistic study.

  Bipolar disorders 20021001

• Neuroprotection in idiopathic Parkinson's disease.

  Journal of neurology 20021001

• Combination of two different dopamine agonists in the management of Parkinson's disease.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20020901

• Two advances in the management of Parkinson disease.

  Cleveland Clinic journal of medicine 20020801

• [The usefulness of dopaminergic drugs in traumatic brain injury].

  Revista de neurologia 20020801

• Acute placebo-controlled sleep laboratory studies and clinical follow-up with pramipexole in restless legs syndrome.

  European archives of psychiatry and clinical neuroscience 20020801

• [Pramipexole in Parkinson disease. Results of a treatment observation].

  Der Nervenarzt 20020801

• Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease.

  JAMA 20020717

• The effects of speech therapy and pharmacological treatments on voice and speech in Parkinson s disease: a review of the literature.

  Current medicinal chemistry 20020701

• Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, double blind, placebo controlled multicentre study.

  Journal of neurology, neurosurgery, and psychiatry 20020601

• Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics.

  Neurology 20020514

• [Dopamine agonist is effective in Parkinson disease not only against tremor. Depression is also improved].

  MMW Fortschritte der Medizin 20020506

• A case of Parkinsonism due to lithium intoxication: treatment with Pramipexole.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20020501

• Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression.

  JAMA 20020403

• Alopecia induced by dopamine agonists.

  Neurology 20020312

• Influence of sildenafil on copulatory behaviour in sluggish or normal ejaculator male rats: a central dopamine mediated effect?

  Neuropharmacology 20020301

• Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.

  Journal of neuroscience research 20020215

• Pramipexole for depression.

  The American journal of psychiatry 20020201

• A review of pramipexole and its clinical utility in Parkinson's disease.

  Expert opinion on pharmacotherapy 20020201

• Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group.

  JAMA 20020101

• Pramipexole ameliorates neurologic and psychiatric symptoms in a Westphal variant of Huntington's disease.

  Clinical neuropharmacology 20020101

• [Rhabdomyolysis as a complication of Parkinson's disease].

  Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20020101

• DA agonists -- non-ergot derivatives: pramipexole: management of Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20020101

• [Use of dopamine agonists in the treatment of Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20020101

• Pramipexole in Parkinson's disease. A short-term study using the combined levodopa-dopamine agonist test.

  Functional neurology 20020101

• Current advances in Parkinson's disease.

  Trends in neurosciences 20010701

• Modafinil and pramipexole-associated somnolence.

  Movement disorders : official journal of the Movement Disorder Society 20010701

• Adjunctive dopamine agonists in treatment-resistant bipolar II depression: an open case series.

  Pharmacopsychiatry 20010701

• Neuroprotective effects of pramipexole in young and aged MPTP-treated mice.

  Brain research 20010629

• Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD.

  Neurology 20010612

• Newer dopamine agonists in the treatment of restless legs syndrome.

  The Annals of pharmacotherapy 20010501

• Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole.

  European journal of pharmacology 20010406

• Antiparkinsonian drugs and 'sleep attacks'.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20010403

• Pramipexole augmentation in panic with agoraphobia.

  The American journal of psychiatry 20010301

• Possible applications for dopaminergic agents following traumatic brain injury: part 2.

  The Journal of head trauma rehabilitation 20010201

• Efficacy and tolerability of dopamine agonists in a parkinsonian population.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20010201

• Switching from pergolide to pramipexole in patients with Parkinson's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 20010101

• A study of excessive daytime sleepiness and its clinical significance in three groups of Parkinson's disease patients taking pramipexole, cabergoline and levodopa mono and combination therapy.

  Journal of neural transmission (Vienna, Austria : 1996) 20010101

• Are dopamine receptor agonists neuroprotective in Parkinson's disease?

  Drugs & aging 20010101

• Increased risk of somnolence with the new dopamine agonists in patients with Parkinson's disease: a meta-analysis of randomised controlled trials.

  Drug safety 20010101

• Does combined treatment with novel antidepressants and a dopamine D3 receptor agonist reproduce cocaine discrimination in rats?

  Polish journal of pharmacology 20010101

• Locomotor hypoactivity and motor disturbances--behavioral effects induced by intracerebellar microinjections of dopaminergic DA-D2/D3 receptor agonists.

  Polish journal of pharmacology 20010101

• [Dopaminergic agonists in the treatment of Parkinson's disease].

  Revue medicale de Bruxelles 20001201

• ['Sleep attacks' in Parkinson patients. A side effect of nonergoline dopamine agonists or a class effect of dopamine agonists?].

  Der Nervenarzt 20000801

• Pramipexole-induced somnolence and episodes of daytime sleep.

  Movement disorders : official journal of the Movement Disorder Society 20000701

• Clinical pharmacology of dopamine agonists.

  Pharmacotherapy 20000101

• Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats.

  European journal of pharmacology 19991126

• Pramipexole treatment for cocaine cravings.

  The American journal of psychiatry 19991101

• Effects of pramipexole on contraversive rotation and functional motor impairments in 1-methyl-4-phenyl1,2,3, 6-tetrahydropyridine-induced chronic hemiparkinsonian monkeys.

  The Journal of pharmacology and experimental therapeutics 19981201

• Involvement of dopamine D2 receptors in the effect of cocaine on sexual behaviour and stretching-yawning of male rats.

  Neuropharmacology 19970601

• The behavioural effects of pramipexole, a novel dopamine receptor agonist.

  European journal of pharmacology 19970411

• Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors.

  European journal of pharmacology 19950623

• Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.

  European journal of pharmacology 19930624