19493-44-8 | 1-Chloroisoquinoline

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$6.00	$4.00
5g	97%	in stock	$17.00	$12.00
10g	97%	in stock	$33.00	$23.00
25g	≥98%	in stock	$53.00	$37.00

Description

• Catalog Number: AD61915
• Chemical Name: 1-Chloroisoquinoline
• CAS Number: 19493-44-8
• Molecular Formula: C9H6ClN
• Molecular Weight: 163.6036
• MDL Number: MFCD00024134
• SMILES: Clc1nccc2c1cccc2
• NSC Number: 170839

Computed Properties

• Complexity: 138
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• XLogP3: 3.2

Upstream Synthesis Route

1-Chloroisoquinoline, a versatile compound widely used in chemical synthesis, serves as a valuable building block for the creation of various pharmaceuticals, agrochemicals, and functional materials. This reactive intermediate is particularly esteemed for its role in the synthesis of heterocyclic compounds due to its ability to undergo diverse chemical transformations. In organic synthesis, 1-Chloroisoquinoline acts as a key starting material in the construction of complex molecular structures, enabling the incorporation of chlorine atoms into target molecules while maintaining the isoquinoline ring scaffold. Its application in modern synthetic chemistry extends to the development of novel drug candidates, fluorescent dyes, and advanced materials with tailored properties. Through strategic manipulation of its chemical reactivity, 1-Chloroisoquinoline facilitates the construction of intricate molecular architectures, making it an essential tool for researchers and synthetic chemists alike striving to access innovative compounds with diverse applications.

Literature

• Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.

  Journal of medicinal chemistry 20111222

• A five-step synthesis of (S)-macrostomine from (S)-nicotine.

  Organic letters 20101015