195447-80-4 | 4-Fluoro-2-(trifluoromethyl)phenylacetic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$29.00	$20.00
1g	98%	in stock	$33.00	$23.00
5g	98%	in stock	$66.00	$46.00
10g	98%	in stock	$123.00	$86.00
25g	98%	in stock	$286.00	$200.00
100g	98%	in stock	$1,003.00	$702.00

Description

• Catalog Number: AB67489
• Chemical Name: 4-Fluoro-2-(trifluoromethyl)phenylacetic acid
• CAS Number: 195447-80-4
• Molecular Formula: C9H6F4O2
• Molecular Weight: 222.1364
• MDL Number: MFCD00061189
• SMILES: OC(=O)Cc1ccc(cc1C(F)(F)F)F

Computed Properties

• Complexity: 239
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.4

Literature

• Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS.

  Toxicology 20150302

• Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1).

  The Journal of biological chemistry 20120921

• Successful pregnancy in a patient suffering from recurrent mid-trimester miscarriage with C9 deficiency after receiving cervical cerclage followed by clindamycin and progesterone: a case report.

  The journal of obstetrics and gynaecology research 20120301

• C9-R95X polymorphism in patients with neovascular age-related macular degeneration.

  Investigative ophthalmology & visual science 20120131

• Fucosylated glycoproteomic approach to identify a complement component 9 associated with squamous cell lung cancer (SQLC).

  Journal of proteomics 20111118

• Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement.

  PLoS neglected tropical diseases 20110701

• Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization.

  The Journal of biological chemistry 20110506

• Membranoproliferative pattern of glomerular injury associated with complement component 9 deficiency due to Arg95Stop mutation.

  Clinical and experimental nephrology 20110201

• Binding to complement factors and activation of the alternative pathway by Acanthamoeba.

  Immunobiology 20110101

• Complement-mediated bacteriolysis after binding of specific antibodies to drug-resistant Pseudomonas aeruginosa: morphological changes observed by using a field emission scanning electron microscope.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20101201

• Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.

  International journal of cancer 20100315

• Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.

  Journal of immunology (Baltimore, Md. : 1950) 20100301

• Complement 5b-9 complex-induced alterations in human RPE cell physiology.

  Medical science monitor : international medical journal of experimental and clinical research 20100101

• Novel complement inhibitor limits severity of experimentally myasthenia gravis.

  Annals of neurology 20090101

• Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis.

  Journal of immunology (Baltimore, Md. : 1950) 20081015

• Plaque complement activation and cognitive loss in Alzheimer's disease.

  Journal of neuroinflammation 20080101

• Anti-C5 antibody treatment ameliorates weakness in experimentally acquired myasthenia gravis.

  Journal of immunology (Baltimore, Md. : 1950) 20071215

• C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack.

  The Journal of biological chemistry 20070928

• Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex.

  Acta crystallographica. Section D, Biological crystallography 20070601

• Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy.

  Cancer immunology, immunotherapy : CII 20070501

• Mapping of the complement C9 binding domain in paramyosin of the blood fluke Schistosoma mansoni.

  International journal for parasitology 20070101

• Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis.

  Journal of immunology (Baltimore, Md. : 1950) 20051215

• Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction.

  Journal of immunology (Baltimore, Md. : 1950) 20051115

• Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement-mediated lysis.

  International immunology 20050901

• IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20050801

• Increased sensitivity of early apoptotic cells to complement-mediated lysis.

  European journal of immunology 20041101

• Serum-resistant strains of Borrelia burgdorferi evade complement-mediated killing by expressing a CD59-like complement inhibitory molecule.

  Journal of immunology (Baltimore, Md. : 1950) 20030315

• An abnormal but functionally active complement component C9 protein found in an Irish family with subtotal C9 deficiency.

  Immunology 20030301

• Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice.

  Journal of immunology (Baltimore, Md. : 1950) 20030201

• The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats.

  Neuroscience letters 20020614

• The effect of pH and nucleophiles on complement activation by human proximal tubular epithelial cells.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020501

• CR2-mediated activation of the complement alternative pathway results in formation of membrane attack complexes on human B lymphocytes.

  Immunology 20011201

• Rhabdomyolysis, acute renal failure, and death after monensin ingestion.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20011101

• The human complement C9 gene: structural analysis of the 5' gene region and genetic polymorphism studies.

  European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 20011001

• Induction of complement C9 messenger RNAs in human neuronal cells by inflammatory stimuli: relevance to neurodegenerative disorders.

  Experimental gerontology 20010701

• Hereditary complement (C9) deficiency associated with dermatomyositis.

  The British journal of dermatology 20010501

• Complement-mediated lipopolysaccharide release and outer membrane damage in Escherichia coli J5: requirement for C9.

  Immunology 20010301

• Systemic complement depletion diminishes perihematomal brain edema in rats.

  Stroke 20010101