197958-29-5 | Pyridine-2-boronic acid

Availability
Typically In Stock

Description

• Catalog Number: AB07601
• Chemical Name: Pyridine-2-boronic acid
• CAS Number: 197958-29-5
• Molecular Formula: C5H6BNO2
• Molecular Weight: 122.9176
• MDL Number: MFCD00151844
• SMILES: OB(c1ccccn1)O

Computed Properties

• Complexity: 89
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1

Upstream Synthesis Route

Pyridine-2-boronic acid is a versatile compound widely used in chemical synthesis as a key building block. It serves as a valuable precursor in the synthesis of various pharmaceuticals, agrochemicals, and functional materials. Its boronic acid functional group enables it to participate in Suzuki-Miyaura cross-coupling reactions, allowing for the formation of carbon-carbon bonds in a controlled and efficient manner. Additionally, Pyridine-2-boronic acid can be employed in the preparation of heterocyclic compounds, which are essential structural motifs in many biologically active molecules. Its ability to facilitate selective and mild transformations makes it a valuable tool for synthetic chemists seeking to access diverse molecular architectures.

Literature

• Quaterpyridine ligands for panchromatic Ru(II) dye sensitizers.

  The Journal of organic chemistry 20120921

• Electronic coupling between two cyclometalated ruthenium centers bridged by 1,3,6,8-tetra(2-pyridyl)pyrene (tppyr).

  Inorganic chemistry 20100920

• A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

  Journal of neuroinflammation 20070101

• A colorimetric titration method for quantification of millimolar glucose in a pH 7.4 aqueous phosphate buffer.

  Bioorganic & medicinal chemistry letters 20050901

• Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.

  The Journal of organic chemistry 20050722

• 2-(6-Bromopyridin-2-yl)-6-methyl-[1,3,6,2]dioxazaborocane, a new stable (pyridin-2-yl)boronic acid derivative.

  Acta crystallographica. Section C, Crystal structure communications 20040801