19829-79-9 | 8-Hydroxyquinoline-7-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$32.00	$22.00
5g	97%	in stock	$43.00	$31.00
10g	97%	in stock	$86.00	$61.00
25g	97%	in stock	$214.00	$150.00

Description

• Catalog Number: AB07906
• Chemical Name: 8-Hydroxyquinoline-7-carboxylic acid
• CAS Number: 19829-79-9
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.1675
• MDL Number: MFCD00671539
• SMILES: OC(=O)c1ccc2c(c1O)nccc2

Computed Properties

• Complexity: 231
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.9

Upstream Synthesis Route

8-Hydroxy-7-quinolinecarboxylic acid, also known as oxine, is a versatile compound widely utilized in chemical synthesis for its diverse applications. In organic chemistry, it serves as a chelating agent that forms stable complexes with various metal ions, making it valuable in analytical chemistry and as a catalyst in organic reactions. Its ability to bind with metals such as aluminum, iron, and copper allows for the selective separation and detection of these ions in solutions. Additionally, 8-Hydroxy-7-quinolinecarboxylic acid is commonly employed in the synthesis of coordination compounds and metal-organic frameworks due to its coordination chemistry properties. Furthermore, it is utilized in the preparation of fluorescent dyes, pharmaceuticals, and other specialty chemicals, highlighting its significance in a range of chemical processes.

Literature

• Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.

  ACS chemical biology 20120316

• A structural and theoretical study of the intermolecular interactions in 8-hydroxyquinolinium-7-carboxylate monohydrate.

  Acta crystallographica. Section C, Crystal structure communications 20110701

• Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.

  Bioorganic & medicinal chemistry letters 20100501

• Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.

  Bioorganic & medicinal chemistry letters 20061101

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• THE IN VITRO EFFECT OF 8-HYDROXYQUINOLINE DERIVATIVES ON STRAINS OF MYCOBACTERIUM TUBERCULOSIS.

  Biochemical pharmacology 19640201