19982-08-2 | 1,3-Dimethyl-5-adamantanamine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$160.00	$112.00
1g	95%	in stock	$322.00	$225.00

Description

• Catalog Number: AB09146
• Chemical Name: 1,3-Dimethyl-5-adamantanamine
• CAS Number: 19982-08-2
• Molecular Formula: C12H21N
• Molecular Weight: 179.3018
• MDL Number: MFCD02114015
• SMILES: CC12CC3CC(C1)(C)CC(C2)(C3)N

Computed Properties

• Complexity: 240
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Undefined Atom Stereocenter Count: 2
• XLogP3: 3.3

Literature

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  Toxicology 20180801

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• Pharmacological prevention and treatment of vascular dementia: approaches and perspectives.

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• Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity.

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• Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40.

  European journal of pharmacology 20121005

• Preliminary studies of (99m)Tc-memantine derivatives for NMDA receptor imaging.

  Nuclear medicine and biology 20121001

• Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.

  Neurobiology of disease 20121001

• Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease.

  Neuropharmacology 20121001

• Underrecognition and undertreatment of dementia in Italian nursing homes.

  Journal of the American Medical Directors Association 20121001

• Clinical trials of dementia with Lewy bodies and Parkinson's disease dementia.

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• Memantine improves safety of thrombolysis for stroke.

  Stroke 20121001

• Racial and ethnic disparities in Alzheimer's disease pharmacotherapy exposure: an analysis across four state Medicaid populations.

  The American journal of geriatric pharmacotherapy 20121001

• A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death.

  The Journal of biological chemistry 20120914

• Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats.

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• Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study.

  International journal of geriatric psychiatry 20120901

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  Pharmacoepidemiology and drug safety 20120901

• Transdermal absorption of memantin--effect of chemical enhancers, iontophoresis, and role of enhancer lipophilicity.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120901

• Subgroup analysis of US and non-US patients in a global study of high-dose donepezil (23 mg) in moderate and severe Alzheimer's disease.

  American journal of Alzheimer's disease and other dementias 20120901

• Effectiveness of the combination of memantine plus vitamin D on cognition in patients with Alzheimer disease: a pre-post pilot study.

  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20120901

• A review of the effects of memantine on clinical progression in Alzheimer's disease.

  International journal of geriatric psychiatry 20120801

• Depressive-like behavior in adrenocorticotropic hormone-treated rats blocked by memantine.

  Pharmacology, biochemistry, and behavior 20120801

• Neuroprotective and neurogenesis agent for treating bipolar II disorder: add-on memantine to mood stabilizer works.

  Medical hypotheses 20120801

• The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence.

  CNS drugs 20120801

• Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors.

  European journal of pharmacology 20120705

• N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

  Current Alzheimer research 20120701

• Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism.

  Psychopharmacology 20120701

• Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.

  Archives of neurology 20120701

• False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine.

  Brain : a journal of neurology 20120701

• Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial.

  Translational psychiatry 20120701

• Glutamatergic approaches in major depressive disorder: focus on ketamine, memantine and riluzole.

  Drugs of today (Barcelona, Spain : 1998) 20120701

• [Effects of ionotropic glutamate receptor channel blockers ON sleep-waking organization in rats].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20120701

• Working memory in the aged Ts65Dn mouse, a model for Down syndrome.

  Behavioural brain research 20120615

• Discontinuing donepezil or starting memantine for Alzheimer's disease.

  The New England journal of medicine 20120607

• Discontinuing donepezil or starting memantine for Alzheimer's disease.

  The New England journal of medicine 20120607

• Cost-effectiveness of memantine in moderate and severe Alzheimer's disease in Norway.

  International journal of geriatric psychiatry 20120601

• The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli.

  Psychopharmacology 20120601

• Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.

  British journal of pharmacology 20120601

• Memantine for axonal loss of optic neuritis.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120601

• Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats.

  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120601

• Memantine potentiates hippocampal θ oscillations at a therapeutic dose in anesthetized mice: a mechanistic link to its cognitive-enhancing properties.

  Neuropharmacology 20120601

• Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.

  Metabolic brain disease 20120601

• Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome.

  Naunyn-Schmiedeberg's archives of pharmacology 20120601

• Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD.

  International journal of geriatric psychiatry 20120601

• Is delay of clinical worsening a valuable goal in the treatment of Alzheimer's disease?

  International journal of geriatric psychiatry 20120601

• Use of antidementia drugs in frontotemporal lobar degeneration.

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• The pharmacological treatment of acquired nystagmus.

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  Prescrire international 20120601

• A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats.

  Life sciences 20120522

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  Annals of biomedical engineering 20120501

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  Alzheimer's & dementia : the journal of the Alzheimer's Association 20120501

• Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS/MS.

  Journal of pharmaceutical and biomedical analysis 20120501

• Memantine facilitates memory consolidation and reconsolidation in the day-old chick.

  Neurobiology of learning and memory 20120501

• Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease.

  Neuro-degenerative diseases 20120501

• Cholinesterase inhibitors and memantine for symptomatic treatment of dementia.

  BMJ (Clinical research ed.) 20120501

• Open-label pilot study of memantine in the treatment of compulsive buying.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20120501

• Economic evaluation of treatment options in patients with Alzheimer's disease: a systematic review of cost-effectiveness analyses.

  Drugs 20120416

• Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain.

  Journal of neural transmission (Vienna, Austria : 1996) 20120401

• Antitussive effects of memantine in guinea pigs.

  Chest 20120401

• New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.

  British journal of clinical pharmacology 20120401

• Memantine partly rescues behavioral and cognitive deficits in an animal model of neurodegeneration.

  Neuropharmacology 20120401

• Cell proliferation in the hippocampus and in the heart is modified by exposure to repeated stress and treatment with memantine.

  Journal of psychiatric research 20120401

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  British journal of clinical pharmacology 20120401

• Structure/function studies and the effects of memantine in monkeys with experimental glaucoma.

  Investigative ophthalmology & visual science 20120401

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  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20120401

• Memantine in Alzheimer's disease: experience in an Alzheimer's disease assessment unit.

  Aging clinical and experimental research 20120401

• Alzheimer disease: Treatment of Alzheimer disease in Down syndrome.

  Nature reviews. Neurology 20120313

• Donepezil and memantine for moderate-to-severe Alzheimer's disease.

  The New England journal of medicine 20120308

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  The New England journal of medicine 20120308

• [Stimulant and non-stimulant medication in current and future therapy for ADHD].

  Fortschritte der Neurologie-Psychiatrie 20120301

• Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection.

  Cephalalgia : an international journal of headache 20120301

• Morphine and memantine treatment of long-standing complex regional pain syndrome.

  Pain medicine (Malden, Mass.) 20120301

• Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.

  Cold Spring Harbor perspectives in medicine 20120301

• The 'blue' side of glutamatergic neurotransmission: NMDA receptor antagonists as possible novel therapeutics for major depression.

  Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20120301

• Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20120211

• Improving Alzheimer's disease outcomes in Down's syndrome.

  Lancet (London, England) 20120211

• Memantine effects on behaviour in moderately severe to severe Alzheimer's disease: a post-marketing surveillance study.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120201

• Determination of memantine in rat plasma by HPLC-fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide.

  Biomedical chromatography : BMC 20120201

• Pharmacologic treatment of apathy in dementia.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20120201

• Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.

  Drugs & aging 20120201

• Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons.

  Hong Kong medical journal = Xianggang yi xue za zhi 20120201

• Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial.

  Bipolar disorders 20120201

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  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20120201

• Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

  Bioorganic & medicinal chemistry 20120115

• Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and neuroprotective effects in in vitro and in vivo.

  Neuroscience letters 20120111

• Detecting treatment effects with combinations of the ADAS-cog items in patients with mild and moderate Alzheimer's disease.

  International journal of geriatric psychiatry 20120101

• Memantine and functional communication in Alzheimer's disease: results of a 12-week, international, randomized clinical trial.

  Journal of Alzheimer's disease : JAD 20120101

• Calpain activation is involved in acute manganese neurotoxicity in the rat striatum in vivo.

  Experimental neurology 20120101

• The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial.

  Journal of affective disorders 20120101

• The N-methyl-d-aspartic acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells.

  Neuro-Signals 20120101

• Differentiation of HT22 neurons induces expression of NMDA receptor that mediates homocysteine cytotoxicity.

  Neurological research 20120101

• Memantine and brain atrophy in Alzheimer's disease: a 1-year randomized controlled trial.

  Journal of Alzheimer's disease : JAD 20120101

• Evaluating the cost effectiveness of donepezil in the treatment of Alzheimer's disease in Germany using discrete event simulation.

  BMC neurology 20120101

• Effects of chronic memantine treatment on hippocampal extracellular glutamate and GABA levels during spatial alternation testing.

  Georgian medical news 20120101

• Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.

  International journal of molecular sciences 20120101

• Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20120101

• Effects of memantine, an N-methyl-D-aspartate receptor antagonist, on fatigue and neuronal brain damage in a rat model of combined (physical and mental) fatigue.

  Biological & pharmaceutical bulletin 20120101

• Gantrez AN nanoparticles for ocular delivery of memantine: in vitro release evaluation in albino rabbits.

  Ophthalmic research 20120101

• The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model.

  Health technology assessment (Winchester, England) 20120101

• Neuroprotective effect of noncompetitive NMDA receptor antagonists IEM-1957 and memantine in experimental focal cerebral ischemia.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20120101

• Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial.

  PloS one 20120101

• Bioanalytical method development and validation of memantine in human plasma by high performance liquid chromatography with tandem mass spectrometry: application to bioequivalence study.

  Journal of analytical methods in chemistry 20120101

• [New anti-AD drugs--their possibilities and issues].

  Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20120101

• Efficacy and safety of donepezil 23 mg versus donepezil 10 mg for moderate-to-severe Alzheimer's disease: a subgroup analysis in patients already taking or not taking concomitant memantine.

  Dementia and geriatric cognitive disorders 20120101

• The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome.

  PloS one 20120101

• A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI.

  The journal of nutrition, health & aging 20120101

• Radiation induces acute alterations in neuronal function.

  PloS one 20120101

• [Efficacy, safety and tolerability of a single dose of akatinol memantine in comparison to two-doses in patients with moderately expressed and moderately severe dementia in Alzheimer's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

• A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers.

  Clinical drug investigation 20120101

• Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.

  PloS one 20120101

• Effect of renal impairment on the pharmacokinetics of memantine.

  Journal of pharmacological sciences 20120101

• Simultaneous determination of Maillard reaction impurities in memantine tablets using HPLC with charged aerosol detector.

  Journal of pharmaceutical and biomedical analysis 20111215

• Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model.

  Brain research 20111202

• Direct costs of Alzheimer's disease in Germany.

  The European journal of health economics : HEPAC : health economics in prevention and care 20111201

• A placebo controlled trial of memantine as an adjunct to oral naltrexone for opioid dependence.

  Drug and alcohol dependence 20111201

• Memantine for posttraumatic stress disorder in an older veteran.

  Journal of clinical psychopharmacology 20111201

• Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine.

  Learning & memory (Cold Spring Harbor, N.Y.) 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Management of moderate to severe Alzheimer's disease: focus on memantine.

  Taiwanese journal of obstetrics & gynecology 20111201

• Effects of the uncompetitive NMDA receptor antagonist memantine on spatial memory in medial septal lesioned rats.

  Georgian medical news 20111201

• [Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos].

  Vojnosanitetski pregled 20111201

• [Memantine].

  Nihon rinsho. Japanese journal of clinical medicine 20111201

• Memantine prevents aluminum-induced cognitive deficit in rats.

  Behavioural brain research 20111120

• ACP Journal Club. Review: cholinesterase inhibitors but not memantine increase syncope in older adults with mild cognitive impairment or dementia.

  Annals of internal medicine 20111115

• Patterns of dementia treatment use in assisted living facilities: a cross-sectional study of 1975 demented residents.

  Journal of the American Medical Directors Association 20111101

• The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20111101

• Effects of memantine, a non-competitive N-methyl-D-aspartate receptor antagonist, on genomic stability.

  Basic & clinical pharmacology & toxicology 20111101

• On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome.

  Developmental neuroscience 20111101

• Does memantine improve the gait of individuals with Alzheimer's disease?

  Journal of the American Geriatrics Society 20111101

• Effective pharmacological management of Alzheimer's disease.

  The American journal of managed care 20111101

• The costs of Alzheimer's disease and the value of effective therapies.

  The American journal of managed care 20111101

• Pharmacologic treatment for memory disorder in multiple sclerosis.

  The Cochrane database of systematic reviews 20111005

• Memantine in systemic lupus erythematosus: a randomized, double-blind placebo-controlled trial.

  Seminars in arthritis and rheumatism 20111001

• Memantine for comorbid obsessive-compulsive disorder and Asperger disorder suggests a link in glutamatergic dysregulation.

  Journal of clinical psychopharmacology 20111001

• A new HPLC method with fluorescence detection for the determination of memantine in human plasma.

  Journal of separation science 20111001

• Use of memantine for the treatment of dementia.

  Expert review of neurotherapeutics 20111001

• Pharmacological treatment of Alzheimer disease.

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20111001

• Economic evaluation of the impact of memantine on time to nursing home admission in the treatment of Alzheimer disease.

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20111001

• The effect of memantine in harmaline-induced tremor and neurodegeneration.

  Neuropharmacology 20110901

• Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before.

  Expert opinion on investigational drugs 20110901

• Drug therapy of post-stroke aphasia: a review of current evidence.

  Neuropsychology review 20110901

• [Effects of glial cell line-derived neurotrophic factor and memantine on long-term prognosis in neonatal rats with periventricular leukomalacia].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110901

• Pharmacological tests of hypotheses for acquired pendular nystagmus.

  Annals of the New York Academy of Sciences 20110901

• Memantine reduces mania-like symptoms in animal models.

  Psychiatry research 20110815

• Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.

  Behavioural brain research 20110810

• The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine.

  Behavioural brain research 20110810

• Determining the minimum clinically important differences for outcomes in the DOMINO trial.

  International journal of geriatric psychiatry 20110801

• Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology.

  Journal of psychopharmacology (Oxford, England) 20110801

• Alzheimer's disease and age-related memory decline (preclinical).

  Pharmacology, biochemistry, and behavior 20110801

• Memantine in moderate to severe Alzheimer's disease: an observational post-marketing study.

  Journal of neural transmission (Vienna, Austria : 1996) 20110801

• Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20110801

• Lack of evidence for the efficacy of memantine in mild Alzheimer disease.

  Archives of neurology 20110801

• [Newly approved drugs for Alzheimer disease: effectiveness and limitation].

  Brain and nerve = Shinkei kenkyu no shinpo 20110801

• New drugs for Alzheimer's disease in Japan.

  Psychiatry and clinical neurosciences 20110801

• Dementia with cardiac problems.

  BMJ (Clinical research ed.) 20110722

• Drugs: a tangled web of targets.

  Nature 20110713

• Antidementia drug prescription sources and patterns after the diagnosis of dementia in Germany: results of a claims data-based 1-year follow-up.

  International clinical psychopharmacology 20110701

• [Daily functioning in dementia: pharmacological and non-pharmacological interventions demonstrate small effects on heterogeneous scales].

  Psychiatrische Praxis 20110701

• [Prescription differences of dementia drugs in urban and rural areas in Germany].

  Psychiatrische Praxis 20110701

• The local anesthetic effect of memantine on infiltrative cutaneous analgesia in the rat.

  Anesthesia and analgesia 20110701

• Tolerability and efficacy of memantine add-on therapy to rivastigmine transdermal patches in mild to moderate Alzheimer's disease: a multicenter, randomized, open-label, parallel-group study.

  Current medical research and opinion 20110701

• Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 20110701

• Cholinesterase inhibitor and memantine use in newly admitted nursing home residents with dementia.

  Journal of the American Geriatrics Society 20110701

• Combination therapy for Alzheimer's disease.

  Drugs & aging 20110701

• Memantine and catatonia: a case report and literature review.

  Journal of psychiatric practice 20110701

• AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 20110701

• Memantine abolishes the formation of cocaine-induced conditioned place preference possibly via its IL-6-modulating effect in medial prefrontal cortex.

  Behavioural brain research 20110620

• Treatment of Alzheimer disease.

  American family physician 20110615

• S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine.

  Psychopharmacology 20110601

• Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction.

  Fitoterapia 20110601

• Peripheral administration of NR2 antagonists attenuates orofacial formalin-induced nociceptive behavior in rats.

  Progress in neuro-psychopharmacology & biological psychiatry 20110601

• Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials.

  Journal of the American Geriatrics Society 20110601

• Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model.

  Neuroscience 20110519

• Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease.

  Neuropharmacology 20110501

• Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

  Neuropharmacology 20110501

• Changes in nursing burden following memantine for agitation and aggression in long-term care residents with moderate to severe Alzheimer's disease: an open-label pilot study.

  CNS drugs 20110501

• Diagnosis of Alzheimer's disease patients with rapid cognitive decline in clinical practice: interest of the Deco questionnaire.

  The journal of nutrition, health & aging 20110501

• Alternative drug therapies for dementia.

  Journal of psychosocial nursing and mental health services 20110501

• Managing the patient with dementia in long-term care.

  Clinics in geriatric medicine 20110501

• Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia.

  Expert review of neurotherapeutics 20110501

• Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal.

  Neuroscience 20110428

• Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine.

  Neurobiology of aging 20110401

• Memantine in dementia: a review of the current evidence.

  Expert opinion on pharmacotherapy 20110401

• Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence.

  Psychiatry research 20110330

• Pharmacologic amelioration of severe hypoglycemia-induced neuronal damage.

  Neuroscience letters 20110329

• Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptors.

  Behavioural brain research 20110317

• AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

  The Biochemical journal 20110315

• Prescribing trends in cognition enhancing drugs in Australia.

  International psychogeriatrics 20110301

• Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.

  Psychopharmacology 20110301

• Memantine for non-motor features of Parkinson's disease: a double-blind placebo controlled exploratory pilot trial.

  Parkinsonism & related disorders 20110301

• Effect of memantine on resting state default mode network activity in Alzheimer's disease.

  Drugs & aging 20110301

• Managing cognitive dysfunction through the continuum of Alzheimer's disease: role of pharmacotherapy.

  CNS drugs 20110301

• Amyloid β peptide oligomers directly activate NMDA receptors.

  Cell calcium 20110301

• Effectiveness of adding memantine to an Alzheimer dementia treatment regimen which already includes stable donepezil therapy: a critically appraised topic.

  The neurologist 20110301

• Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells.

  Biochemical and biophysical research communications 20110218

• Memantine reduces consumption of highly palatable food in a rat model of binge eating.

  Amino acids 20110201

• Efficacy of memantine in PDD and DLB: an extension study including washout and open-label treatment.

  International journal of geriatric psychiatry 20110201

• Activation of brain histaminergic neurotransmission: a mechanism for cognitive effects of memantine in Alzheimer's disease.

  The Journal of pharmacology and experimental therapeutics 20110201

• Administration of memantine during ethanol withdrawal in neonatal rats: effects on long-term ethanol-induced motor incoordination and cerebellar Purkinje cell loss.

  Alcoholism, clinical and experimental research 20110201

• Memantine prevents hypoglycemia-induced decrements of the cerebral energy status in healthy subjects.

  The Journal of clinical endocrinology and metabolism 20110201

• The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats.

  Epilepsy research 20110201

• [Pharmacological treatment of nystagmus].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20110201

• High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization.

  Journal of separation science 20110201

• Glutamate receptors in laryngeal cancer cells.

  Anticancer research 20110201

• [Clinical rehabilitative effect of memantine on cognitive and motor disorders in patients with Parkinson's disease].

  Zhonghua yi xue za zhi 20110201

• [Memantine: the value of combined therapy].

  Revista de neurologia 20110116

• Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors.

  The Journal of biological chemistry 20110114

• Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells.

  Cell death and differentiation 20110101

• Targeting glutamate mediated excitotoxicity in Huntington's disease: neural progenitors and partial glutamate antagonist--memantine.

  Medical hypotheses 20110101

• Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs.

  Neuropharmacology 20110101

• Memantine in behavioral variant frontotemporal dementia: negative results.

  Journal of Alzheimer's disease : JAD 20110101

• Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative.

  Archives of neurology 20110101

• Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.

  Molecular pain 20110101

• CDR state transition probabilities in Alzheimer's disease with and without cholinesterase inhibitor intervention in an observational cohort.

  Journal of Alzheimer's disease : JAD 20110101

• A double-blind, double-dummy, randomized controlled study of memantine versus buprenorphine in naloxone-precipitated acute withdrawal in heroin addicts.

  Journal of opioid management 20110101

• Sustained effects of once-daily memantine treatment on cognition and functional communication skills in patients with moderate to severe Alzheimer's disease: results of a 16-week open-label trial.

  Journal of Alzheimer's disease : JAD 20110101

• Measuring therapeutic efficacy in patients with Alzheimer's disease: role of instruments.

  Dementia and geriatric cognitive disorders 20110101

• An immunohistochemical analysis of the neuroprotective effects of memantine, hyperbaric oxygen therapy, and brimonidine after acute ischemia reperfusion injury.

  Molecular vision 20110101

• The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats.

  Neurotoxicology and teratology 20110101

• Huntington's disease: effect of memantine on FDG-PET brain metabolism?

  The Journal of neuropsychiatry and clinical neurosciences 20110101

• Alzheimer's disease: a review of recent developments.

  Annals of African medicine 20110101

• Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats.

  Neuropharmacology 20110101

• Neuroprotective effect of memantine on hippocampal neurons in infantile rat hydrocephalus.

  Turkish neurosurgery 20110101

• Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.

  Molecular vision 20110101

• Memantine affects cognitive flexibility in the Morris water maze.

  Journal of Alzheimer's disease : JAD 20110101

• A memantin HCL intoxication responsive to plasmapheresis therapy.

  Bratislavske lekarske listy 20110101

• MR spectroscopy for assessment of memantine treatment in mild to moderate Alzheimer dementia.

  Journal of Alzheimer's disease : JAD 20110101

• Alzheimer's disease--input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial.

  Trials 20110101

• Acute pharmacokinetics of memantine in the mouse.

  Pharmacology 20110101

• Determination of memantine in plasma and vitreous humour by HPLC with precolumn derivatization and fluorescence detection.

  Journal of chromatographic science 20110101

• Quality of life and the effect of memantine in dementia with lewy bodies and Parkinson's disease dementia.

  Dementia and geriatric cognitive disorders 20110101

• The use of acetyl cholinesterase inhibitors and memantine in nursing home residents.

  Acta clinica Belgica 20110101

• Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats.

  Neuro endocrinology letters 20110101

• Activation of N-methyl D-aspartate (NMDA) receptors has no influence on rheological properties of erythrocytes.

  Clinical hemorheology and microcirculation 20110101

• Memantine in everyday clinical practice: a comparison of studies in Germany and Greece.

  Dementia and geriatric cognitive disorders 20110101

• [Mental disorders following delirium tremens].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• Chronic catatonia with obsessive compulsive disorder symptoms treated with lorazepam, memantine, aripiprazole, fluvoxamine and neurosurgery.

  BMJ case reports 20110101

• Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study.

  Psychopharmacology 20101201

• A pilot trial of memantine and riluzole in ALS: correlation to CSF biomarkers.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20101201

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• [Effects of electroacupuncture on expression of Abeta positive cells of the hippocampus and SOD activity in rats with streptozocin-Alzheimer's disease].

  Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20101201

• Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists.

  Bioorganic & medicinal chemistry 20101115

• [Treatment of dementia].

  MMW Fortschritte der Medizin 20101104

• Memantine is a useful drug to prevent the spatial and non-spatial memory deficits induced by methamphetamine in rats.

  Pharmacological research 20101101

• Treatment options of cognitive impairment in multiple sclerosis.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20101101

• [Memantine in the pharmacologic treatment of moderately severe to severe Alzheimer's disease in Spain (MEMORY study)].

  Revista de neurologia 20101101

• Memantine discontinuation and the health status of nursing home residents with Alzheimer's disease.

  Journal of the American Medical Directors Association 20101101

• NMDA receptor antagonists for the treatment of neuropathic pain.

  Pain medicine (Malden, Mass.) 20101101

• Memantine benefits functional abilities in moderate to severe Alzheimer's disease.

  The journal of nutrition, health & aging 20101101

• A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis.

  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20101001

• NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation.

  Pain 20101001

• Efficacy of akatinol memantine in moderate cognitive impairments.

  Neuroscience and behavioral physiology 20101001

• Effects of memantine on convulsive reactions and the organization of sleep in krushinskii-molodkina rats with an inherited predisposition to audiogenic convulsions.

  Neuroscience and behavioral physiology 20101001

• Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial.

  The Lancet. Neurology 20101001

• [Vascular dementia].

  Der Nervenarzt 20101001

• In vivo evidence for functional NMDA receptor blockade by memantine in rat hippocampal neurons.

  Journal of neural transmission (Vienna, Austria : 1996) 20101001

• Improving fragile X-associated tremor/ataxia syndrome symptoms with memantine and venlafaxine.

  Journal of clinical psychopharmacology 20101001

• Effect of memantine in Alzheimer's disease evaluated by visual-evoked potentials to pattern-reversal, motion-onset, and cognitive stimuli.

  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20101001

• Differential pharmacological responses of catatonia-like signs in frontotemporal dementia.

  Neurocase 20101001

• The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia.

  International journal of geriatric psychiatry 20101001

• HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities.

  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100901

• Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: an NMDA receptor-independent mechanism.

  Neurochemistry international 20100901

• A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period.

  Drug and alcohol dependence 20100901

• Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats.

  The Korean journal of pain 20100901

• Once-daily memantine: pharmacokinetic and clinical considerations.

  Journal of the American Geriatrics Society 20100901

• Current treatments for patients with Alzheimer disease.

  The Journal of the American Osteopathic Association 20100901

• Modern care for patients with Alzheimer disease: rationale for early intervention.

  The Journal of the American Osteopathic Association 20100901

• Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100818

• Pharmacologic dissociation between impulsivity and alcohol drinking in high alcohol preferring mice.

  Alcoholism, clinical and experimental research 20100801

• Predictors of adherence among Alzheimer's disease patients receiving oral therapy.

  Current medical research and opinion 20100801

• HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress.

  Journal of neuropathology and experimental neurology 20100801

• Drugmakers dance with autism.

  Nature biotechnology 20100801

• Profile: Nicholas Dodman. Can dogs behaving badly suggest a new way to treat OCD?

  Science (New York, N.Y.) 20100723

• Memantine exacerbates myoclonic jerks in a rat model of posthypoxic myoclonus.

  Brain research 20100709

• Breast cancer expresses functional NMDA receptors.

  Breast cancer research and treatment 20100701

• Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.

  Journal of neuroscience research 20100701

• Effect of memantine treatment on regional cortical metabolism in Alzheimer's disease.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20100701

• Memantine ER, a once-daily formulation for the treatment of Alzheimer's disease.

  Expert opinion on pharmacotherapy 20100701

• Memantine-related psychotic symptoms in a patient with bipolar disorder.

  The Journal of clinical psychiatry 20100701

• [Drug therapy for Alzheimer's disease].

  Brain and nerve = Shinkei kenkyu no shinpo 20100701

• Clinical practice. Early Alzheimer's disease.

  The New England journal of medicine 20100610

• Dose-related effects of memantine on a mismatch negativity-like response in anesthetized rats.

  Neuroscience 20100602

• A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors.

  International journal of geriatric psychiatry 20100601

• Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review.

  Pharmacological research 20100601

• Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.

  The Journal of pharmacology and experimental therapeutics 20100601

• Changes in cerebral glucose metabolism in patients with posttraumatic cognitive impairment after memantine therapy: a preliminary study.

  Annals of nuclear medicine 20100601

• Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application.

  Electrophoresis 20100601

• Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.

  Bioorganic & medicinal chemistry 20100601

• Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20100601

• How do we treat people with dementia in Croatia.

  Psychiatria Danubina 20100601

• Effects of the uncompetitive nmda receptor antagonist memantine on recognition memory in rats.

  Georgian medical news 20100601

• Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro.

  Toxicology 20100527

• Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.

  Journal of medicinal chemistry 20100513

• Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-D-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells.

  Neuroscience 20100505

• Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke.

  Investigative ophthalmology & visual science 20100501

• Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning.

  Neurobiology of learning and memory 20100501

• Effects of the non-competitive NMDA receptor antagonist memantine on the volitional consumption of ethanol by alcohol-preferring rats.

  Basic & clinical pharmacology & toxicology 20100501

• Combination treatments in Alzheimer's disease: risks and benefits.

  Expert review of neurotherapeutics 20100501

• Crossover trial of gabapentin and memantine as treatment for acquired nystagmus.

  Annals of neurology 20100501

• Effect of memantine on overactive detrusor in rats with spinal cord injury.

  The Kaohsiung journal of medical sciences 20100501

• [Cost of illness in Alzheimer's disease].

  Medizinische Klinik (Munich, Germany : 1983) 20100501

• Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder.

  Bipolar disorders 20100501

• [Variability and trends in dementia drug consumption in Castile-La Mancha (Spain). Estimated prevalence of Alzheimer's disease].

  Neurologia (Barcelona, Spain) 20100501

• Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

  Brain research bulletin 20100405

• A 1H-MR spectroscopy study of changes in glutamate and glutamine (Glx) concentrations in frontal spectra after administration of memantine.

  Cerebral cortex (New York, N.Y. : 1991) 20100401

• Safety and tolerability of rivastigmine capsule with memantine in patients with probable Alzheimer's disease: a 26-week, open-label, prospective trial (Study ENA713B US32).

  International journal of geriatric psychiatry 20100401

• Regulation of Kv2.1 phosphorylation in an animal model of anoxia.

  Neurobiology of disease 20100401

• Memantine improves memory for taste-avoidance learning in day-old chicks exposed to isolation stress.

  Pharmacology, biochemistry, and behavior 20100401

• [New perspectives on molecular and genic therapies in Down syndrome].

  Medecine sciences : M/S 20100401

• NMDA antagonist memantine improves levodopa-induced dyskinesias and 'on-off' phenomena in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20100315

• Acquired pendular nystagmus in multiple sclerosis: an examiner-blind cross-over treatment study of memantine and gabapentin.

  Journal of neurology 20100301

• Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy.

  European journal of neurology 20100301

• Prescribing of drugs for Alzheimer's disease: a South African database analysis.

  International psychogeriatrics 20100301

• Off-label medication use in frontotemporal dementia.

  American journal of Alzheimer's disease and other dementias 20100301

• [Lying with statistic--today: the meta-analysis].

  Deutsche medizinische Wochenschrift (1946) 20100301

• [On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease].

  Fortschritte der Neurologie-Psychiatrie 20100301

• Solid state stabilisation of the orally delivered drugs atenolol, glibenclamide, memantine and paracetamol through their complexation with cucurbit[7]uril.

  Organic & biomolecular chemistry 20100221

• Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells.

  Neuroscience letters 20100205

• A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer's disease: a post hoc analysis.

  Current medical research and opinion 20100201

• Deramciclane improves object recognition in rats: potential role of NMDA receptors.

  Pharmacology, biochemistry, and behavior 20100201

• Memantine: 'hypothesis testing' not 'disease modifying' in Alzheimer's disease.

  The American journal of pathology 20100201

• A randomized trial of memantine as treatment for spasticity in multiple sclerosis.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20100201

• Use of memantine (akatinol) for the correction of cognitive impairments in Parkinson's disease complicated by dementia.

  Neuroscience and behavioral physiology 20100201

• Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.

  The American journal of pathology 20100201

• Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.

  Cell calcium 20100201

• A single-blinded case-control study of memantine in severe obsessive-compulsive disorder.

  Journal of clinical psychopharmacology 20100201

• The dysregulation of intracellular calcium in Alzheimer disease.

  Cell calcium 20100201

• Model of methadone-induced hyperalgesia in rats and effect of memantine.

  European journal of pharmacology 20100125

• Studies on wakefulness-promoting effect of memantine in rats.

  Behavioural brain research 20100120

• Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.

  Brain research 20100114

• Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice.

  Journal of neuroscience research 20100101

• Eight-year prescription trends of memantine and cholinesterase inhibitors among persons 65 years and older in Germany.

  International clinical psychopharmacology 20100101

• New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.

  Bioorganic & medicinal chemistry 20100101

• Pharmacological treatment of Alzheimer's disease: effect of race and demographic variables.

  Journal of Alzheimer's disease : JAD 20100101

• Lack of association between serum brain-derived neurotrophic factor levels and improvement of schizophrenia symptoms in a double-blind, randomized, placebo-controlled trial of memantine as adjunctive therapy to clozapine.

  The Journal of clinical psychiatry 20100101

• Folic Acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model.

  Journal of Alzheimer's disease : JAD 20100101

• Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.

  BMC neuroscience 20100101

• Lower Barthel Index scores predict less prescription of pharmacological therapy in elderly patients with Alzheimer disease.

  Dementia and geriatric cognitive disorders 20100101

• Drugs for Alzheimer's disease.

  Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20100101

• Memantine for AIDS dementia complex: open-label report of ACTG 301.

  HIV clinical trials 20100101

• Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats.

  Journal of orofacial pain 20100101

• Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

  Journal of Alzheimer's disease : JAD 20100101

• Cost effectiveness of memantine in Alzheimer's disease in the UK.

  Journal of medical economics 20100101

• [Consensus statement 'Dementia 2010' of the Austrian Alzheimer Society].

  Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20100101

• [Memantine for treatment of behavioural disturbances and psychotic symptoms in moderate to moderately severe Alzheimer dementia: a naturalistic study in outpatient services in Austria].

  Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20100101

• Comparison of adverse drug reactions with donepezil versus memantine: analysis of the French Pharmacovigilance Database.

  Therapie 20100101

• Pilot trial of memantine in primary progressive aphasia.

  Alzheimer disease and associated disorders 20100101

• A pilot efficacy and tolerability trial of memantine for essential tremor.

  Clinical neuropharmacology 20100101

• Late onset Alzheimer's disease in older people.

  Clinical interventions in aging 20100101

• [Treatment of Alzheimer's disease and future approaches].

  Therapie 20100101

• Characterisation of the expression of NMDA receptors in human astrocytes.

  PloS one 20100101

• Sensitive and rapid HPLC method for determination of memantine in human plasma using OPA derivatization and fluorescence detection: application to pharmacokinetic studies.

  Scientia pharmaceutica 20100101

• [Akatinol memantine in patients with vascular cognitive disorders].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [Clinical features of the formation and possibilities of treatment of posttraumatic cognitive disturbances].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Differences between physician and caregiver evaluations in Alzheimer's disease.

  Functional neurology 20100101

• [The use of akatinol memantine in the residual phase of stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Dementia.

  BMJ clinical evidence 20100101

• Autism.

  BMJ clinical evidence 20100101

• Effects of memantine on soluble Alphabeta(25-35)-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions.

  Neuroscience 20091215

• Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons.

  Cellular and molecular neurobiology 20091201

• Open-label memantine in fragile X syndrome.

  Journal of autism and developmental disorders 20091201

• International price comparisons of Alzheimer's drugs: a way to close the affordability gap.

  International psychogeriatrics 20091201

• Memantine for the prophylaxis of chronic tension-type headache.

  Current pain and headache reports 20091201

• Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.

  Nature medicine 20091201

• Memantine strikes the perfect balance.

  Nature medicine 20091201

• [Alzheimer dementia. Memantine: value for patient and caregivers].

  MMW Fortschritte der Medizin 20091105

• The effects of the glutamate antagonist memantine on brain activation to an auditory perception task.

  Human brain mapping 20091101

• Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.

  Journal of molecular neuroscience : MN 20091101

• Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions.

  Current opinion in psychiatry 20091101

• The effect of memantine and levodopa/carbidopa on the responses of phrenic nerve-diaphragm preparations from aged rats.

  Medical science monitor : international medical journal of experimental and clinical research 20091101

• Effects of anti-dementia drugs on morphine-induced somnolence.

  Biological & pharmaceutical bulletin 20091101

• Alzheimer's disease: Seeing the signs early.

  Journal of the American Academy of Nurse Practitioners 20091101

• Minimally-responsive head injury survivors may have chronic catatonia reversed years after an accident.

  Singapore medical journal 20091101

• Cost-effectiveness: cholinesterase inhibitors and memantine in vascular dementia.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20091101

• The effects of NMDA receptor antagonists over intestinal ischemia/reperfusion injury in rats.

  European journal of pharmacology 20091025

• Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist.

  Toxicology and applied pharmacology 20091015

• Emerging role of glutamate in the pathophysiology of major depressive disorder.

  Brain research reviews 20091001

• Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management.

  Current opinion in anaesthesiology 20091001

• Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.

  The Journal of physiology 20091001

• Memantine: a review of its use in moderate to severe Alzheimer's disease.

  CNS drugs 20091001

• Improvement of negative and positive symptoms in treatment-refractory schizophrenia: a double-blind, randomized, placebo-controlled trial with memantine as add-on therapy to clozapine.

  The Journal of clinical psychiatry 20091001

• [Final report is now available. IQWiG doubts the effectiveness of memantine].

  MMW Fortschritte der Medizin 20090924

• Memantine blocks sensitization to the rewarding effects of morphine.

  Brain research 20090908

• Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein.

  Cellular and molecular neurobiology 20090901

• Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine.

  Brain : a journal of neurology 20090901

• Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090901

• Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors.

  Journal of palliative medicine 20090901

• Treatment effects of Memantine on language in moderate to severe Alzheimer's disease patients.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 20090901

• Current Alzheimer's disease clinical trials: methods and placebo outcomes.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 20090901

• Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress.

  Clinics (Sao Paulo, Brazil) 20090901

• Dual action of memantine in Alzheimer disease: a hypothesis.

  Taiwanese journal of obstetrics & gynecology 20090901

• Memanti-nium chloride 0.1-hydrate.

  Acta crystallographica. Section E, Structure reports online 20090901

• The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus.

  Glia 20090801

• Combined use of pregabalin and memantine in fibromyalgia syndrome treatment: a novel analgesic and neuroprotective strategy?

  Medical hypotheses 20090801

• Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.

  Neuropharmacology 20090801

• Neuroprotection: extrapolating from neurologic diseases to the eye.

  American journal of ophthalmology 20090801

• The pharmacological treatment of nystagmus: a review.

  Expert opinion on pharmacotherapy 20090801

• Memantine: heart failure: harmful drug.

  Prescrire international 20090801

• [Effects of memantine on convulsive reactions and sleep-waking cycle in Krushinskiĭ-Molodkina strain rats with the inherited predisposition to audiogenic convulsions].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090801

• Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury.

  Brain research 20090728

• Efficacy and safety of memantine in Lewy body dementia.

  Neuroscience and behavioral physiology 20090701

• Memantine: a new hope for treatment of Lewy body-related dementias?

  The Lancet. Neurology 20090701

• Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial.

  The Lancet. Neurology 20090701

• An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons.

  Apoptosis : an international journal on programmed cell death 20090701

• Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons.

  Neurotoxicity research 20090701

• Randomized controlled trial of memantine in dementia associated with Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20090615

• Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine.

  Investigative ophthalmology & visual science 20090601

• Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned.

  Acta ophthalmologica 20090601

• Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease.

  Journal of neurology, neurosurgery, and psychiatry 20090601

• The effects of memantine on prepulse inhibition.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090601

• Two cases of discontinuation syndrome following cessation of memantine.

  Geriatrics & gerontology international 20090601

• [Antidementia drugs].

  Therapeutische Umschau. Revue therapeutique 20090601

• The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder.

  Experimental and clinical psychopharmacology 20090601

• Effects of memantine on latent inhibition of active avoidance in wistar rats.

  Bulletin of experimental biology and medicine 20090601

• Age at onset of first depressive episode as a predictor for escitalopram treatment of major depression comorbid with alcohol dependence.

  Psychiatry research 20090515

• Treatment of Alzheimer's disease in the long-term-care setting.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090515

• Memantine induces reversible neurologic impairment in patients with MS.

  Neurology 20090512

• Understanding pseudo: the symptoms are real, the cause is unclear.

  Neurology 20090512

• Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090501

• Effects of memantine on cognition in patients with moderate to severe Alzheimer's disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, double-blind, placebo-controlled studies.

  International journal of geriatric psychiatry 20090501

• Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study.

  Biological & pharmaceutical bulletin 20090501

• Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task.

  Neuroscience letters 20090501

• Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats.

  Pharmacology, biochemistry, and behavior 20090501

• Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia.

  Annals of neurology 20090501

• Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.

  Bioorganic & medicinal chemistry 20090415

• Memantine treatment reduces the expression of the K(+)/Cl(-) cotransporter KCC2 in the hippocampus and cerebral cortex, and attenuates behavioural responses mediated by GABA(A) receptor activation in mice.

  Brain research 20090410

• A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090401

• NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus.

  Neuroscience research 20090401

• Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors.

  Neuropharmacology 20090401

• Treatment practices of mild cognitive impairment in California Alzheimer's Disease Centers.

  Journal of the American Geriatrics Society 20090401

• Update on neuropsychiatric symptoms of dementia: evaluation and management.

  Geriatrics 20090401

• Drugs to treat Alzheimer's disease.

  Journal of psychosocial nursing and mental health services 20090401

• When should drug treatment be started for people with dementia?

  Maturitas 20090320

• Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090304

• [Treatment of degenerative dementia disorders--who should be treated?].

  Ugeskrift for laeger 20090302

• N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.

  Neurochemical research 20090301

• Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study.

  Acta neurologica Scandinavica 20090301

• Memantine for prophylaxis of chronic tension-type headache--a double-blind, randomized, crossover clinical trial.

  Cephalalgia : an international journal of headache 20090301

• Memantine and acetylcholinesterase inhibitor treatment in cases of CDR 0.5 or questionable impairment.

  Journal of Alzheimer's disease : JAD 20090301

• Memantine in the preventive treatment for migraine and refractory migraine.

  Headache 20090301

• Memantine (Namenda, Forest Pharmaceuticals).

  Issues in mental health nursing 20090301

• Characteristic effects of anti-dementia drugs on rat sleep patterns.

  Journal of pharmacological sciences 20090301

• [Therapy of Alzheimer disease].

  Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20090301

• Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.

  Brain research 20090213

• Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: application to a clinical pharmacokinetic study.

  Biomedical chromatography : BMC 20090201

• Glutamate-induced NFkappaB activation in the retina.

  Investigative ophthalmology & visual science 20090201

• Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina.

  Investigative ophthalmology & visual science 20090201

• Memantine augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial.

  Journal of clinical psychopharmacology 20090201

• Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.

  British journal of pharmacology 20090201

• Three steps forward, two steps back in helping people with dementia.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20090201

• Memantine dosing in patients with dementia.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20090201

• Psychosis in the elderly.

  The American journal of psychiatry 20090201

• Memantine as an augmenting agent for severe pediatric OCD.

  The American journal of psychiatry 20090201

• Racial/ethnic disparities in medication use among veterans with hypertension and dementia: a national cohort study.

  The Annals of pharmacotherapy 20090201

• New developments in the treatment of Alzheimer's disease.

  The Journal of clinical psychiatry 20090201

• Memantine for dementia in people with Down syndrome.

  The Cochrane database of systematic reviews 20090121

• Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition.

  Biochemical and biophysical research communications 20090116

• Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity.

  Toxicology letters 20090110

• Differential involvement of glutamatergic mechanisms in the cognitive and subjective effects of smoking.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

• Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats.

  Epilepsy & behavior : E&B 20090101

• Nightmares and memantine: a case report and review of literature.

  Journal of the American Medical Directors Association 20090101

• Memantine therapy of behavioral symptoms in community-dwelling patients with moderate to severe Alzheimer's disease.

  Dementia and geriatric cognitive disorders 20090101

• Memantine (Namenda) for neuropathic pain.

  The American journal of hospice & palliative care 20090101

• Differential efficacy of memantine for obsessive-compulsive disorder vs. generalized anxiety disorder: an open-label trial.

  Psychopharmacology bulletin 20090101

• Memantine: a comprehensive review of safety and efficacy.

  Expert opinion on drug safety 20090101

• Donepezil in severe Alzheimer's disease.

  American journal of Alzheimer's disease and other dementias 20090101

• Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network.

  Dementia and geriatric cognitive disorders 20090101

• Protective effect of memantine against Doxorubicin toxicity in primary neuronal cell cultures: influence a development stage.

  Neurotoxicity research 20090101

• Memantine in moderately-severe-to-severe Alzheimer's disease: a postmarketing surveillance study.

  Drugs & aging 20090101

• Treatment of acquired periodic alternating nystagmus with memantine: a case report.

  Clinical neuropharmacology 20090101

• Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: a pilot evaluation.

  Clinical neuropharmacology 20090101

• DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT.

  Trials 20090101

• Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine.

  Cellular & molecular biology letters 20090101

• Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20090101

• Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology.

  Journal of Alzheimer's disease : JAD 20090101

• [Efficacy of acatinol memantine in mild cognitive disorder].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Current treatments of Alzheimer disease: are main caregivers satisfied with the drug treatments received by their patients?

  Dementia and geriatric cognitive disorders 20090101

• An open-label study of memantine treatment in 3 subtypes of frontotemporal lobar degeneration.

  Alzheimer disease and associated disorders 20090101

• Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias.

  Clinical interventions in aging 20090101

• Variability in the prescription of cholinesterase inhibitors and memantine.

  Dementia and geriatric cognitive disorders 20090101

• Anti-apoptotic effect of memantine against staurosporine- and low-potassium-induced cell death in cerebellar granule cells: a development-dependent effect.

  Pharmacological reports : PR 20090101

• Treatments for fragile X syndrome: a closer look at the data.

  Developmental disabilities research reviews 20090101

• Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine.

  Current molecular pharmacology 20090101

• Three-year follow-up of a patient with early-onset Alzheimer's disease with presenilin-2 N141I mutation - case report and review of the literature.

  European journal of medical research 20081203

• Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201

• Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine.

  Journal of neurology, neurosurgery, and psychiatry 20081201

• [Pharmacotherapy of central oculomotor disorders].

  Der Nervenarzt 20081201

• Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201

• Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine.

  Alcoholism, clinical and experimental research 20081201

• Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues.

  Bioorganic & medicinal chemistry letters 20081201

• Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.

  Bioorganic & medicinal chemistry 20081201

• New approaches to the treatment of frontotemporal lobar degeneration.

  Current opinion in neurology 20081201

• Influence of NMDA and non-NMDA antagonists on acute and inflammatory pain in the trigeminal territory: a placebo control study.

  Arquivos de neuro-psiquiatria 20081201

• The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats.

  European journal of pharmacology 20081119

• Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20081104

• The effect of 12-week open-label memantine treatment on cognitive function improvement in patients with alcohol-related dementia.

  The international journal of neuropsychopharmacology 20081101

• Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081101

• Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation.

  The European journal of neuroscience 20081101

• Randomized, placebo-controlled, crossover trial of memantine for cognitive changes with corticosteroid therapy.

  Biological psychiatry 20081015

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from Xenopus oocytes.

  Journal of neural transmission (Vienna, Austria : 1996) 20081001

• Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats.

  Behavioural pharmacology 20081001

• Pharmacological treatment in moderate-to-severe Alzheimer's disease.

  Expert opinion on pharmacotherapy 20081001

• Early use of memantine for neuropathic pain.

  Anesthesia and analgesia 20081001

• Profound pain reduction after induction of memantine treatment in two patients with severe phantom limb pain.

  Anesthesia and analgesia 20081001

• Ultra-low dose ketamine and memantine treatment for pain in an opioid-tolerant oncology patient.

  Anesthesia and analgesia 20081001

• Cholinesterase inhibitors and memantine: best practices.

  CNS spectrums 20081001

• Memantine in the preventive treatment of refractory migraine.

  Headache 20081001

• Tolerability of switching from donepezil to memantine treatment in patients with moderate to severe Alzheimer's disease.

  International journal of geriatric psychiatry 20080901

• Memantine in the treatment of binge eating disorder: an open-label, prospective trial.

  The International journal of eating disorders 20080901

• Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity.

  Journal of neuroscience research 20080901

• A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine.

  Psychopharmacology 20080901

• Does memantine induce bradycardia? A study in the French PharmacoVigilance Database.

  Pharmacoepidemiology and drug safety 20080901

• Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain.

  American journal of physiology. Gastrointestinal and liver physiology 20080901

• Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging.

  Journal of neuroscience research 20080901

• Blocking NMDA receptor signaling does not decrease hormonal counterregulation to hypoglycemia in humans.

  Psychoneuroendocrinology 20080901

• Ca2+ inhibits the association of memantine with N-methyl-D-aspartate (NMDA) receptor-gated ion channels.

  Biological & pharmaceutical bulletin 20080901

• Normal pressure hydrocephalus presenting as Othello syndrome: case presentation and review of the literature.

  The American journal of psychiatry 20080901

• The effect of N-methyl-D-aspartate receptor antagonist (memantine) on esophageal and gastric smooth muscle: functional investigation in a rat hydrocephalus model.

  Journal of pediatric surgery 20080901

• [Alzheimer type dementia].

  Revue de l'infirmiere 20080901

• Racial and ethnic disparities in the treatment of dementia among Medicare beneficiaries.

  The journals of gerontology. Series B, Psychological sciences and social sciences 20080901

• Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.

  Journal of medicinal chemistry 20080814

• Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080801

• A systematic review of off-label uses of memantine for psychiatric disorders.

  Progress in neuro-psychopharmacology & biological psychiatry 20080801

• Cognitive and behavioural impairment in Parkinson's disease.

  International review of psychiatry (Abingdon, England) 20080801

• Methylmercury increases N-methyl-D-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity.

  Toxicology 20080730

• Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats.

  European journal of pharmacology 20080728

• A 6-month, open-label study of memantine in patients with frontotemporal dementia.

  International journal of geriatric psychiatry 20080701

• Assessing transneuronal dysfunction utilizing manganese-enhanced MRI (MEMRI).

  Magnetic resonance in medicine 20080701

• Alzheimer's disease--towards more patient-centred and meaningful clinical outcomes.

  Annals of the Academy of Medicine, Singapore 20080701

• NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080625

• Neuroprotective effects of memantine in a mouse model of retinal degeneration induced by rotenone.

  Brain research 20080618

• Memantine does not show intracellular block of the NMDA receptor channel.

  European journal of pharmacology 20080610

• Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080601

• Effects of memantine and MK-801 on ischemia in an experimental model of acute subdural hematoma.

  Neurological research 20080601

• Cognition-enhancing and anxiolytic effects of memantine.

  Neuropharmacology 20080601

• Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents.

  Neuropharmacology 20080601

• Current and future therapy in Alzheimer's disease.

  Fundamental & clinical pharmacology 20080601

• Galantamine-induced pisa syndrome: memantine as an alternative.

  International journal of geriatric psychiatry 20080601

• Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats.

  Behavioral neuroscience 20080601

• Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20080601

• Combined blockade of AMPA and NMDA receptors in the brain of rats prevents pentylenetetrazole-induced clonic and tonic-clonic seizures without ataxia.

  Bulletin of experimental biology and medicine 20080601

• Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.

  European journal of pharmacology 20080531

• Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour.

  Behavioural brain research 20080516

• Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.

  Biochemical and biophysical research communications 20080516

• Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study.

  Progress in neuro-psychopharmacology & biological psychiatry 20080515

• The use of the hippocampal slice preparation in the study of Alzheimer's disease.

  European journal of pharmacology 20080506

• Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease.

  Acta neurologica Scandinavica 20080501

• Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis.

  International journal of geriatric psychiatry 20080501

• Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model.

  Anesthesiology 20080501

• Dementia medications in palliative care #174.

  Journal of palliative medicine 20080501

• Memantine enhances the inhibitory effects of naltrexone on ethanol consumption.

  European journal of pharmacology 20080428

• Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080423

• Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism.

  Neuroscience letters 20080418

• Memantine-induced hepatitis with cholestasis in a very elderly patient.

  Annals of internal medicine 20080415

• AAFP and ACP release guideline on dementia treatment.

  American family physician 20080415

• Non-associative learning in larval zebrafish.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401

• Tinnitus treatment with memantine.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080401

• Pharmacokinetics of single-dose and multiple-dose memantine in healthy chinese volunteers using an analytic method of liquid chromatography-tandem mass spectrometry.

  Clinical therapeutics 20080401

• Suppression of saccadic intrusions in hereditary ataxia by memantine.

  Neurology 20080304

• Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.

  Annals of internal medicine 20080304

• Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.

  Annals of internal medicine 20080304

• Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.

  Annals of internal medicine 20080304

• Effects of the NMDA receptor antagonist memantine on the expression and development of acute opiate dependence as assessed by withdrawal-potentiated startle and hyperalgesia.

  Psychopharmacology 20080301

• Improvement of contextual memory by S 24795 in aged mice: comparison with memantine.

  Psychopharmacology 20080301

• Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies.

  The Journal of clinical psychiatry 20080301

• Memantine-induced myoclonus and delirium exacerbated by trimethoprim.

  The Annals of pharmacotherapy 20080301

• The spectrum of recurrent thoughts and behaviors in frontotemporal dementia.

  CNS spectrums 20080301

• Course, prognosis, and management of psychosis in Parkinson's disease: are current treatments really effective?

  CNS spectrums 20080301

• Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence.

  The Journal of clinical psychiatry 20080301

• Psychosis and agitation in dementia: should general psychiatrists care?

  The Journal of clinical psychiatry 20080301

• Effects of memantine on mitochondrial function.

  Biochemical pharmacology 20080215

• Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain.

  Neurobiology of aging 20080201

• Transient allodynia pain models in mice for early assessment of analgesic activity.

  British journal of pharmacology 20080201

• Addition of memantine to antipsychotic treatment in schizophrenia inpatients with residual symptoms: A preliminary study.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080201

• Resolution of superior oblique myokymia with memantine.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20080201

• NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats.

  Psychopharmacology 20080201

• Memantine agonist action at dopamine D2High receptors.

  Synapse (New York, N.Y.) 20080201

• Memantine and NMDA antagonism for chronic migraine: a potentially novel therapeutic approach?

  Headache 20080201

• Ketamine followed by memantine for the treatment of major depression.

  The Australian and New Zealand journal of psychiatry 20080201

• Evaluation of drugs for treatment of prion infections of the central nervous system.

  The Journal of general virology 20080201

• History of neuroprotection and rationale as a therapy for glaucoma.

  The American journal of managed care 20080201

• Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial.

  Current Alzheimer research 20080201

• Pharmacologic management of Alzheimer disease.

  The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20080201

• Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study.

  Journal of Alzheimer's disease : JAD 20080201

• Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases.

  Bulletin of experimental biology and medicine 20080201

• Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

  Journal of medicinal chemistry 20080124

• Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter.

  Glia 20080115

• Some treatment dilemmas in rapidly developing dementia: a case report.

  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20080101

• Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.

  The Journal of physiology 20080101

• Memantine prevents MDMA-induced neurotoxicity.

  Neurotoxicology 20080101

• The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.

  Neurochemistry international 20080101

• Efficacy of memantine on behavioral and psychological symptoms related to dementia: a systematic meta-analysis.

  The Annals of pharmacotherapy 20080101

• Acute treatment with low doses of memantine does not impair aversive, non-associative and recognition memory in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20080101

• NMDA receptor blockade: a novel avenue for tobacco intervention?

  Medical hypotheses 20080101

• Memantine in major depression with catatonic features.

  The Journal of neuropsychiatry and clinical neurosciences 20080101

• Glutamatergic approaches to the treatment of cognitive and behavioural symptoms of Alzheimer's disease.

  Neuro-degenerative diseases 20080101

• Interaction of memantine and ketamine in morphine- and pentazocine-induced antinociception in mice.

  Pharmacological reports : PR 20080101

• Steady-state pharmacokinetics of rivastigmine in patients with mild to moderate Alzheimer's disease not affected by co-administration of memantine: an open-label, crossover, single-centre study.

  Clinical drug investigation 20080101

• [Features of memantine action profile in cholinergic deficit and intracerebral posttraumatic hematoma (hemorrhagic stroke) models in rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• Memantine therapy for Alzheimer disease in real-world practice: an observational study in a large representative sample of French patients.

  Alzheimer disease and associated disorders 20080101

• Factors affecting usage patterns of memantine in Alzheimer disease.

  Alzheimer disease and associated disorders 20080101

• Memantine for the treatment of Alzheimer's disease: tolerability and safety data from clinical trials.

  Drug safety 20080101

• [Efficacy and safety of memantine in dementia with Lewy bodies].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Long-term course and effectiveness of combination therapy in Alzheimer disease.

  Alzheimer disease and associated disorders 20080101

• The use of truncated area under the curves in the bioequivalence evaluation of long half-life drugs. Studies with donepezil and memantine.

  Arzneimittel-Forschung 20080101

• Symptomatic therapeutic aspects in Alzheimer's disease.

  Handbook of clinical neurology 20080101

• Behavioral effects of current Alzheimer's disease treatments: a descriptive review.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 20080101

• [Pathogenetic therapy of spasticity].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Memantine potentiates agonist-induced Ca2+ responses in HEK 293 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• Memantine protects against secondary neuronal degeneration in lateral geniculate nucleus and superior colliculus after retinal damage in mice.

  CNS neuroscience & therapeutics 20080101

• Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database.

  Neuroepidemiology 20080101

• [Therapy of Alzheimer's disease: current status and future development].

  Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20080101

• Treatment of alcohol dependence in patients with co-morbid major depressive disorder--predictors for the outcomes with memantine and escitalopram medication.

  Substance abuse treatment, prevention, and policy 20080101

• Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma.

  Progress in brain research 20080101

• [Memantine (akatinol) therapy of cognitive impairment in Parkinson's disease complicated by dementia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [Efficacy of memantine in Parkinson's disease with dementia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Discontinuing Alzheimer's disease drug therapy: why, when, and how.

  Director (Cincinnati, Ohio) 20080101

• [Effect of memantine treatment on patients with moderate-to-severe Alzheimer's disease treated with donepezil].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101

• The uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial-arm maze memory task.

  European journal of pharmacology 20071201

• Memantine normalizes brain activity in the inferior frontal gyrus: a controlled pilot fMRI study.

  Schizophrenia research 20071201

• Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy.

  Current medical research and opinion 20071201

• [Practical clinical use of therapeutic agents for Alzheimer's disease].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20071201

• Memantine acts as a cholinergic stimulant in the mouse hippocampus.

  Journal of Alzheimer's disease : JAD 20071201

• The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects.

  Current psychiatry reports 20071201

• Expression of N-methyl-d-aspartate receptor 1 in rats with chronic ocular hypertension.

  Neuroscience 20071123

• Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.

  Neuropharmacology 20071101

• Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats.

  Investigative ophthalmology & visual science 20071101

• Incidence of cholinergic and memantine treatment in Alzheimer's disease in Finland.

  Journal of the American Geriatrics Society 20071101

• Weight-loss associated with anti-dementia drugs in a patient with Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20071015

• A pilot study of the clinical efficacy and safety of memantine for Huntington's disease.

  Parkinsonism & related disorders 20071001

• [Management of Alzheimer disease].

  Presse medicale (Paris, France : 1983) 20071001

• Memantine and recognition memory: possible facilitation of its behavioral effects by the nitric oxide (NO) donor molsidomine.

  European journal of pharmacology 20071001

• Memantine reduces neuronal dysfunctions triggered by in vitro ischemia and 3-nitropropionic acid.

  Experimental neurology 20071001

• A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder.

  Experimental neurology 20071001

• Pathologically activated therapeutics for neuroprotection.

  Nature reviews. Neuroscience 20071001

• Diagnosis and management of vascular cognitive impairment.

  Current atherosclerosis reports 20071001

• [Are anti-dementia drugs worthwhile?].

  MMW Fortschritte der Medizin 20070913

• Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study.

  AIDS (London, England) 20070912

• New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma.

  Journal of pharmaceutical and biomedical analysis 20070903

• Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.

  Bioorganic & medicinal chemistry letters 20070901

• Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-D-aspartate receptors by memantine.

  Neuropharmacology 20070901

• Alzheimer's disease: will advances made in the past turn the tide?

  The Annals of pharmacotherapy 20070901

• Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials.

  The Lancet. Neurology 20070901

• Memantine for prevention of migraine: a retrospective study of 60 cases.

  The journal of headache and pain 20070901

• Animal behavior case of the month. Canine compulsive disorder.

  Journal of the American Veterinary Medical Association 20070815

• Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers.

  Psychopharmacology 20070801

• Memantine inhibits ATP-dependent K+ conductances in dopamine neurons of the rat substantia nigra pars compacta.

  The Journal of pharmacology and experimental therapeutics 20070801

• Exacerbation of myoclonus by memantine in a patient with Alzheimer disease.

  Journal of clinical psychopharmacology 20070801

• Treating autism pharmacologically: also tacrine might improve symptomatology in some cases.

  Journal of child neurology 20070801

• Memantine-induced decompensation in a patient with lewy body dementia.

  Annals of the Academy of Medicine, Singapore 20070801

• Cost-effectiveness of memantine compared with standard care in moderate-to-severe Alzheimer disease in Canada.

  Canadian journal of psychiatry. Revue canadienne de psychiatrie 20070801

• Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis.

  Bulletin of experimental biology and medicine 20070801

• Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.

  European journal of pharmacology 20070702

• Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20070701

• Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study.

  Journal of Alzheimer's disease : JAD 20070701

• Memantine-associated reversal of clozapine-induced weight gain.

  Pharmacopsychiatry 20070701

• Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats.

  Neuroscience 20070608

• High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands.

  Brain research 20070602

• Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070601

• Glutamate antagonists seem to be slightly effective in psychopharmacologic treatment of autism.

  Journal of clinical psychopharmacology 20070601

• [Use of specific drugs for Alzheimer's disease].

  Neurologia (Barcelona, Spain) 20070601

• The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humans.

  Experimental and clinical psychopharmacology 20070601

• Successful treatment of Parkinson disease with memantine.

  Southern medical journal 20070601

• Effects of NMDA receptor antagonist memantine on mismatch negativity.

  Brain research bulletin 20070530

• [Frequently occurring forms of dizziness and their treatment].

  MMW Fortschritte der Medizin 20070521

• NMDA receptor antagonists: tools in neuroscience with promise for treating CNS pathologies.

  The Journal of physiology 20070515

• Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference.

  Progress in neuro-psychopharmacology & biological psychiatry 20070509

• Visual hallucinations and agitation in Alzheimer's disease due to memantine: report of three cases.

  Journal of neurology, neurosurgery, and psychiatry 20070501

• A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI).

  International journal of geriatric psychiatry 20070501

• Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine.

  The Journal of pharmacology and experimental therapeutics 20070501

• Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.

  Molecular pharmacology 20070501

• The after-effect of human theta burst stimulation is NMDA receptor dependent.

  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20070501

• A pilot double-blind treatment trial of memantine for alcohol dependence.

  Alcoholism, clinical and experimental research 20070501

• Investigational treatment for vascular cognitive impairment.

  Expert opinion on investigational drugs 20070501

• Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation.

  Current drug targets 20070501

• Cost-effectiveness of memantine in moderate-to-severe Alzheimer's disease patients receiving donepezil.

  Current medical research and opinion 20070501

• Therapies for Alzheimer's disease.

  Nature reviews. Drug discovery 20070501

• Postmortem memantine concentrations.

  Journal of analytical toxicology 20070501

• Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability.

  Journal of child neurology 20070501

• Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.

  The Journal of biological chemistry 20070413

• Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees.

  European journal of pain (London, England) 20070401

• Determination of memantine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

• Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam.

  Alcoholism, clinical and experimental research 20070401

• Failure to improve the effect of thrombolysis by memantine in a rat embolic stroke model.

  Neurological research 20070401

• [Synthesis and neuroprotective activity in cell culture of aminoadamantane analogues].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070401

• Serendipitous improvement in the Yips associated with memantine use.

  Movement disorders : official journal of the Movement Disorder Society 20070315

• A retrospective study of memantine in children and adolescents with pervasive developmental disorders.

  Psychopharmacology 20070301

• Memantine fails to facilitate partial cigarette deprivation in smokers--no role of Memantine in the treatment of nicotine dependency?

  Journal of neural transmission (Vienna, Austria : 1996) 20070301

• Neuronal oxidative injury and dendritic damage induced by carbofuran: protection by memantine.

  Toxicology and applied pharmacology 20070301

• Safety and tolerability of once-daily versus twice-daily memantine: a randomised, double-blind study in moderate to severe Alzheimer's disease.

  International journal of geriatric psychiatry 20070301

• Treatment strategies for the behavioral symptoms of Alzheimer's disease: focus on early pharmacologic intervention.

  Pharmacotherapy 20070301

• Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice.

  Investigative ophthalmology & visual science 20070301

• Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients.

  The American journal of psychiatry 20070301

• Open label, multicenter, 28-week extension study of the safety and tolerability of memantine in patients with mild to moderate Alzheimer's disease.

  Journal of neurology 20070301

• Aripiprazole worsening positive symptoms and memantine reducing negative symptoms in a patient with paranoid schizophrenia.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20070301

• Different conclusions about memantine.

  Canadian family physician Medecin de famille canadien 20070301

• NMDA receptor-mediated excitotoxicity contributes to the cerebral hypoxic injury of a rat model of posthypoxic myoclonus.

  Brain research 20070216

• Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.

  Bioorganic & medicinal chemistry 20070201

• Memantine in the treatment of mild-to-moderate Alzheimer's disease.

  Expert opinion on pharmacotherapy 20070201

• A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer's disease.

  Expert opinion on drug metabolism & toxicology 20070201

• Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin.

  Annals of neurology 20070201

• Anti-Alzheimer drugs: life-threatening adverse effects.

  Prescrire international 20070201

• A pilot evaluation of the safety, tolerability, pharmacokinetics, and effectiveness of memantine in pediatric patients with attention-deficit/hyperactivity disorder combined type.

  Journal of child and adolescent psychopharmacology 20070201

• Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage.

  Neuroscience letters 20070116

• Memantine as a neuroprotective agent in early phases of psychosis.

  Medical hypotheses 20070101

• Effects of ionotropic glutamate receptor channel blockers on the development of pentylenetetrazol kindling in mice.

  Neuroscience and behavioral physiology 20070101

• Glutamate-modulating drugs & the treatment of mental disorders.

  Journal of psychosocial nursing and mental health services 20070101

• [Akatinol memantine in the therapy of cognitive disorders in Parkinson's disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• Memantine treatment of complex regional pain syndrome: a preliminary report of six cases.

  The Clinical journal of pain 20070101

• Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: secondary analyses from a placebo-controlled randomized trial.

  Alzheimer disease and associated disorders 20070101

• Domain-specific improvement of cognition on memantine in patients with Alzheimer's disease treated with rivastigmine.

  Dementia and geriatric cognitive disorders 20070101

• Primary progressive aphasia.

  Cleveland Clinic journal of medicine 20070101

• Memantine in the treatment of dementia.

  Neuroepidemiology 20070101

• Memantine in moderate to severe Alzheimer's disease: a meta-analysis of randomised clinical trials.

  Dementia and geriatric cognitive disorders 20070101

• A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease.

  Alzheimer disease and associated disorders 20070101

• Memantine for behavioral disturbances in frontotemporal dementia: a case series.

  Alzheimer disease and associated disorders 20070101

• An open-label, flexible-dose study of memantine in major depressive disorder.

  Clinical neuropharmacology 20070101

• Memantine pharmacotherapy: a naturalistic study using a population pharmacokinetic approach.

  Clinical pharmacokinetics 20070101

• Treatment of Alzheimer's disease: the role of symptomatic agents in an era of disease-modifying therapies.

  Reviews in neurological diseases 20070101

• Memantine (Ebixa) in clinical practice - results of an observational study.

  Dementia and geriatric cognitive disorders 20070101

• Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease.

  Dementia and geriatric cognitive disorders 20070101

• Pilot trial of memantine in the treatment of posttraumatic stress disorder.

  Psychiatry 20070101

• Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease.

  Dementia and geriatric cognitive disorders 20070101

• A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists--in vitro characterization.

  Journal of neural transmission (Vienna, Austria : 1996) 20070101

• Modelling disease progression in Alzheimer's disease: a review of modelling methods used for cost-effectiveness analysis.

  PharmacoEconomics 20070101

• Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.

  The Journal of neuropsychiatry and clinical neurosciences 20070101

• [Alzheimer Disease].

  Canadian family physician Medecin de famille canadien 20070101

• [Alzheimer drugs for mild cognitive impairment].

  Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20070101

• [Combined blockade of GluR1 AMPA and NMDA receptors effectively eliminates neurological disorders in rats with experimental allergic encephalomyelitis].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• Memantine as an example of a fast, voltage-dependent, open channel N-methyl-D-aspartate receptor blocker.

  Methods in molecular biology (Clifton, N.J.) 20070101

• [Neuroprotection in glaucoma].

  Annales Academiae Medicae Stetinensis 20070101

• In vitro galantamine-memantine co-application: mechanism of beneficial action.

  Neuropharmacology 20061201

• Pharmacokinetics and disposition of memantine in the arterially perfused bovine eye.

  Pharmaceutical research 20061201

• Salicylate- and quinine-induced tinnitus and effects of memantine.

  Acta oto-laryngologica. Supplementum 20061201

• Clock drawing and frontal lobe behavioral effects of memantine in Alzheimer's disease: a rater-blinded study.

  American journal of Alzheimer's disease and other dementias 20061201

• Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease.

  Brain research 20061106

• Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat.

  Neuroscience 20061103

• Treatment of dementia: anything new?

  Current opinion in psychiatry 20061101

• Cholinesterase inhibitors and memantine have a role in the treatment of Alzheimer's disease.

  Nature clinical practice. Neurology 20061101

• Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology.

  Journal of psychopharmacology (Oxford, England) 20061101

• Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease.

  Neuroscience letters 20061030

• Cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and MK-801.

  European journal of pharmacology 20061024

• Shift shown in influenza A adamantane resistance.

  JAMA 20061004

• [Medical treatment of Alzheimer's disease].

  Ugeskrift for laeger 20061002

• [Retrospective comparative analysis of antidementia medication persistence patterns in Spanish Alzheimer's disease patients treated with donepezil, rivastigmine, galantamine and memantine].

  Revista de neurologia 20061001

• Use of antidementia agents in vascular dementia: beyond Alzheimer disease.

  Mayo Clinic proceedings 20061001

• Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.

  Pharmacology, biochemistry, and behavior 20061001

• A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders.

  Journal of child and adolescent psychopharmacology 20061001

• Behavioral effects of aminoadamantane class NMDA receptor antagonists on schedule-induced alcohol and self-administration of water in mice.

  Psychopharmacology 20060901

• Altered synaptic function in Alzheimer's disease.

  European journal of pharmacology 20060901

• New pathways in drug discovery for Alzheimer's disease.

  Current neurology and neuroscience reports 20060901

• Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine.

  Behavioural pharmacology 20060901

• Shedding light on Alzheimer's.

  The Nurse practitioner 20060901

• From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20060901

• Memantine may acutely improve cognition and have a mood stabilizing effect in treatment-resistant bipolar disorder.

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20060901

• Memantine augmentation for refractory obsessive-compulsive disorder.

  Progress in neuro-psychopharmacology & biological psychiatry 20060830

• Use of memantine to treat Alzheimer's disease.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060829

• [Advances in Alzheimer's disease treatment].

  La Revue de medecine interne 20060801

• Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060801

• Clinical experience with risperidone and memantine in the treatment of Huntington's disease.

  Journal of the National Medical Association 20060801

• A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy.

  Journal of neurovirology 20060801

• Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment.

  Neurology 20060711

• Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.

  FEBS letters 20060710

• Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization.

  Biological psychiatry 20060701

• The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study.

  The British journal of ophthalmology 20060701

• Pharmacology of acetylcholinesterase inhibitors and N-methyl-D-aspartate receptors for combination therapy in the treatment of Alzheimer's disease.

  Journal of clinical pharmacology 20060701

• Rationale for combination therapy with galantamine and memantine in Alzheimer's disease.

  Journal of clinical pharmacology 20060701

• Clinically relevant pharmacology of neuropsychiatric drugs approved over the last three years: part I.

  Journal of psychiatric practice 20060701

• Dementia with lewy bodies: therapeutic opportunities and pitfalls.

  The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060701

• Cost-effectiveness of memantine in community-based Alzheimer's disease patients: An adaptation in Spain.

  The European journal of health economics : HEPAC : health economics in prevention and care 20060601

• Alzheimer's disease: beware of interactions with cholinesterase inhibitors.

  Prescrire international 20060601

• Memantine: the next trend in academic performance enhancement?

  The Journal of the American Osteopathic Association 20060601

• The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601

• Memantine for disruptive behavior in autistic disorder.

  The Journal of clinical psychiatry 20060601

• [Memantine and Complex Regional Pain Syndrome (CRPS): effects of treatment and cortical reorganisation].

  Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... 20060601

• [Anti-dementia drugs for dementia syndromes--just unkept promises?].

  MMW Fortschritte der Medizin 20060515

• Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits.

  Brain research 20060509

• Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent.

  Biomedical chromatography : BMC 20060501

• A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil.

  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060501

• [Glutamate-related excitotoxicity neuroprotection with memantine, an uncompetitive antagonist of NMDA-glutamate receptor, in Alzheimer's disease and vascular dementia].

  Revista de neurologia 20060501

• What's new in clinical pharmacology and therapeutics.

  WMJ : official publication of the State Medical Society of Wisconsin 20060501

• Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity.

  The European journal of neuroscience 20060501

• Memantine for dementia.

  The Cochrane database of systematic reviews 20060419

• [The practice guideline 'Diagnosis and pharmaceutical treatment of dementia'].

  Nederlands tijdschrift voor geneeskunde 20060415

• Low doses of memantine disrupt memory in adult rats.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060412

• Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice.

  Behavioural brain research 20060403

• Memantine reduces hematoma expansion in experimental intracerebral hemorrhage, resulting in functional improvement.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060401

• Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice.

  The Journal of pharmacology and experimental therapeutics 20060401

• Effects of memantine, haloperidol, and cocaine on primary and conditioned reinforcement associated with cocaine in rhesus monkeys.

  Psychopharmacology 20060401

• [New therapeutic options in Alzheimer's disease].

  Revista de neurologia 20060401

• Visual hallucinations from the addition of riluzole to memantine and bupropion.

  Journal of clinical psychopharmacology 20060401

• [Clinical efficacy and safety of akatinol memantine in treatment of mild to moderate Alzheimer disease: a donepezil-controlled, randomized trial].

  Zhonghua nei ke za zhi 20060401

• Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study.

  Brain research bulletin 20060331

• Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats.

  European journal of pharmacology 20060327

• Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice.

  Neuroscience letters 20060306

• In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors.

  Neurobiology of aging 20060301

• [The action of memantine on the cognitive disorders of patients with dementia: reflections following two years' experience in Spain].

  Revista de neurologia 20060301

• Nationwide use of medicines for Alzheimer's disease by community-dwelling persons in Finland.

  Journal of the American Geriatrics Society 20060301

• Observations from a 14-week open-label trial with memantine suggest variable response on behavioral symptoms and cognition, depending on former treatment of AD.

  International psychogeriatrics 20060301

• Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells.

  Neuroscience letters 20060220

• Effects of pharmacologically induced changes in NMDA receptor activity on human timing and sensorimotor performance.

  Brain research 20060216

• [New options for the pharmacotherapy of Alzheimer disease after the approval of memantine? Re the article from DMW 8/2005].

  Deutsche medizinische Wochenschrift (1946) 20060210

• Mechanism of action of memantine.

  Current opinion in pharmacology 20060201

• Catatonic schizophrenia and the use of memantine.

  The Annals of pharmacotherapy 20060201

• Glutamate receptors on human melanocytes regulate the expression of MiTF.

  Pigment cell research 20060201

• Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond.

  Nature reviews. Drug discovery 20060201

• Alzheimer's treatment in nursing homes: room for improvement.

  Journal of the American Medical Directors Association 20060201

• Dementia assessment and management.

  Journal of the American Medical Directors Association 20060201

• Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20060201

• [Long-term effects of memantine therapy on neonatal rats with hypoxic-ischemic brain damage].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060201

• I remember.

  Canadian family physician Medecin de famille canadien 20060201

• Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures.

  Brain research 20060119

• Reinstatement of morphine-conditioned reward is blocked by memantine.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101

• Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060101

• Alarming arbitrariness in EU prescription and reimbursement criteria for anti-dementia drugs.

  International journal of geriatric psychiatry 20060101

• A double-blind, placebo-controlled study of memantine in the treatment of major depression.

  The American journal of psychiatry 20060101

• What we can learn from open-label extensions of randomized clinical trials.

  Archives of neurology 20060101

• A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease.

  Archives of neurology 20060101

• Rivastigmine monotherapy and combination therapy with memantine in patients with moderately severe Alzheimer's disease who failed to benefit from previous cholinesterase inhibitor treatment.

  International journal of clinical practice 20060101

• The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease.

  Health technology assessment (Winchester, England) 20060101

• Pharmacokinetic study of memantine in healthy and renally impaired subjects.

  Clinical pharmacology and therapeutics 20060101

• Memantine increases cardiovascular but not behavioral effects of cocaine in methadone-maintained humans.

  Pharmacology, biochemistry, and behavior 20060101

• Possible role of excitotoxicity in the pathogenesis of glaucoma.

  Clinical & experimental ophthalmology 20060101

• Nurses warn Alzheimer's drugs ban will lead to more sedation.

  Nursing times 20060101

• Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date.

  Alzheimer disease and associated disorders 20060101

• Managing discontinuation syndrome in patients with dementia.

  Journal of psychiatry & neuroscience : JPN 20060101

• [Open angle glaucoma: epidemiology, pathogenesis and prevention].

  Recenti progressi in medicina 20060101

• A systematic review of the clinical and cost-effectiveness of memantine in patients with moderately severe to severe Alzheimer's disease.

  Drugs & aging 20060101

• Neuropathologic changes in Alzheimer's disease: potential targets for treatment.

  The Journal of clinical psychiatry 20060101

• Navigating patients and caregivers through the course of Alzheimer's disease.

  The Journal of clinical psychiatry 20060101

• Contemporary issues in the treatment of Alzheimer's disease: tangible benefits of current therapies.

  The Journal of clinical psychiatry 20060101

• Neuroprotection in vascular dementia.

  Cerebrovascular diseases (Basel, Switzerland) 20060101

• Amantadine and memantine in catatonic schizophrenia.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20060101

• Magnesium supplementation in the treatment of dementia patients.

  Medical hypotheses 20060101

• 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.

  Hippocampus 20060101

• Memantine: a review of its use in Alzheimer's disease.

  Drugs 20060101

• Treatment effect size of memantine therapy in Alzheimer disease and vascular dementia.

  Alzheimer disease and associated disorders 20060101

• [Pharmacotherapy for Alzheimer's disease].

  Tijdschrift voor psychiatrie 20060101

• Realistic expectations for treatment success in Alzheimer's disease.

  The journal of nutrition, health & aging 20060101

• Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity.

  Pharmacological reports : PR 20060101

• Disease-modifying therapies in Alzheimer's disease: how far have we come?

  Drugs 20060101

• Alzheimer disease and its management: a review.

  American journal of therapeutics 20060101

• Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis.

  Alzheimer disease and associated disorders 20060101

• Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment.

  Alzheimer disease and associated disorders 20060101

• Added therapeutic value of memantine in the treatment of moderate to severe Alzheimer's disease.

  Clinical drug investigation 20060101

• Comparison of donepezil and memantine for protective effect against amyloid-beta(1-42) toxicity in rat septal neurons.

  Neuroscience letters 20051231

• Topical and systemic drug delivery to the posterior segments.

  Advanced drug delivery reviews 20051213

• [Efficacy of memantine in the treatment of Alzheimer's disease].

  Neurologia (Barcelona, Spain) 20051201

• Exacerbation of Lewy bodies dementia due to memantine.

  Journal of Alzheimer's disease : JAD 20051201

• Dementia.

  Clinical evidence 20051201

• Drugs for Alzheimer disease.

  Canadian family physician Medecin de famille canadien 20051110

• Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model.

  The European journal of neuroscience 20051101

• Memantine for treatment-resistant OCD.

  The American journal of psychiatry 20051101

• Rationalizing therapeutic approaches in Alzheimer's disease.

  CNS spectrums 20051101

• [Little behavior improvement with memantine].

  Medizinische Monatsschrift fur Pharmazeuten 20051101

• [Effects of blockade of ionotropic glutamate receptors on the development of pentylenetetrazole kindling in mice].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20051101

• Interaction between neurotransmitter antagonists and effects of sacral neuromodulation in rats with chronically hyperactive bladder.

  BJU international 20051001

• Treatment approaches to symptoms associated with frontotemporal degeneration.

  Current psychiatry reports 20051001

• Memantine: a therapeutic approach in treating Alzheimer's and vascular dementia.

  Current drug targets. CNS and neurological disorders 20051001

• Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study.

  Clinical therapeutics 20051001

• Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic rats.

  European journal of pharmacology 20050905

• Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels.

  The Journal of pharmacology and experimental therapeutics 20050901

• Antipsychotic dose-sparing effect with addition of memantine.

  The Annals of pharmacotherapy 20050901

• Spontaneous bruising as a possible adverse reaction to memantine.

  Internal medicine journal 20050901

• UK government guidance on Alzheimer's drugs postponed.

  Drug discovery today 20050901

• [Memantine as an adjunctive therapy for schizophrenia negative symptoms].

  Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20050901

• Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons.

  Brain research 20050809

• Delusions and hallucinations in dementia with Lewy bodies: worsening with memantine.

  Neurology 20050809

• An evaluation of the reinforcing effects of memantine in cocaine-dependent humans.

  Drug and alcohol dependence 20050801

• The use of memantine in dementia with Lewy bodies.

  Journal of Alzheimer's disease : JAD 20050801

• Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats.

  Behavioural brain research 20050730

• Memantine for dementia.

  The Cochrane database of systematic reviews 20050720

• A new anti-obesity drug treatment: first clinical evidence that, antagonising glutamate-gated Ca2+ ion channels with memantine normalises binge-eating disorders.

  Economics and human biology 20050701

• [Pharmacological therapy in Alzheimer's disease. Current clinical practice in The Netherlands].

  Tijdschrift voor gerontologie en geriatrie 20050701

• Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

  Psychopharmacology 20050601

• Combination drug therapies for AD: progress is slow, but we must keep trying.

  Geriatrics 20050601

• Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?

  Geriatrics 20050601

• Measuring treatment response in Alzheimer's disease clinical trials.

  Geriatrics 20050601

• Mild cognitive impairment and preclinical Alzheimer's disease.

  Geriatrics 20050601

• Refining treatment guidelines in Alzheimer's disease.

  Geriatrics 20050601

• Cost-effectiveness of memantine for moderate to severe Alzheimer's disease in Sweden.

  The American journal of geriatric pharmacotherapy 20050601

• N-methyl-D-aspartate receptor in human prostate cancer.

  The Journal of membrane biology 20050601

• [Modern therapy for dementia].

  MMW Fortschritte der Medizin 20050517

• [Assessment of dementia and use of anti-dementia drugs in nursing homes].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050504

• Comments on 'Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than N-methyl-D-aspartate receptors in rat hippocampal neurons'.

  The Journal of pharmacology and experimental therapeutics 20050501

• Steady-state pharmacokinetics of galantamine are not affected by addition of memantine in healthy subjects.

  Journal of clinical pharmacology 20050501

• Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies.

  International journal of geriatric psychiatry 20050501

• A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice.

  Behavioural pharmacology 20050501

• Development of subtle psychotic symptoms with memantine: a case report.

  The Journal of clinical psychiatry 20050501

• Antidementia agents: what is important in this class.

  Managed care (Langhorne, Pa.) 20050501

• Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.

  Current medical research and opinion 20050501

• Memantine for dementia.

  The Cochrane database of systematic reviews 20050418

• Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.

  Psychopharmacology 20050401

• 19F and 1H MRI detection of amyloid beta plaques in vivo.

  Nature neuroscience 20050401

• The effects of memantine on lipid peroxidation following closed-head trauma in rats.

  Neurosurgical review 20050401

• Alzheimer disease, in living color.

  Nature neuroscience 20050401

• The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism.

  Current Alzheimer research 20050401

• Simultaneous determination of the binding of amantadine and its analogues to synthetic melanin by liquid chromatography after precolumn derivatization with dansyl chloride.

  Journal of chromatographic science 20050401

• NICE proposes to withdraw Alzheimer's drugs from NHS.

  BMJ (Clinical research ed.) 20050305

• Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons.

  The Journal of pharmacology and experimental therapeutics 20050301

• Carbofuran-induced oxidative stress in slow and fast skeletal muscles: prevention by memantine and atropine.

  Toxicology 20050301

• Memantine and catatonic schizophrenia.

  The American journal of psychiatry 20050301

• Memantine for treatment of moderate to severe Alzheimer's disease.

  Issues in emerging health technologies 20050301

• Is there a double standard when it comes to dementia care?

  International journal of clinical practice. Supplement 20050301

• Memantine alleviates toxicity induced by dichlorvos in rats.

  Journal of occupational health 20050301

• [Pharmacological treatment in severe dementia].

  Psychologie & neuropsychiatrie du vieillissement 20050301

• Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.

  Journal of the American Academy of Nurse Practitioners 20050301

• Alzheimer's disease care management plan: maximizing patient care.

  Journal of the American Academy of Nurse Practitioners 20050301

• [New options for the pharmacotherapy of Alzheimer's disease after the registration of memantine?].

  Deutsche medizinische Wochenschrift (1946) 20050225

• Seizures associated with memantine use.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050215

• Effect of memantine on the alpha 7 neuronal nicotinic receptors, synaptophysin- and low molecular weight MAP-2 levels in the brain of transgenic mice over-expressing human acetylcholinesterase.

  Journal of neural transmission (Vienna, Austria : 1996) 20050201

• Memantine and progressive glaucoma.

  Journal of glaucoma 20050201

• 2004 drug approval highlights: FDA update.

  The Nurse practitioner 20050201

• [Advanced dementia in Alzheimer's disease and memantine].

  Revista de neurologia 20050201

• Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model.

  Pharmacology 20050101

• Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope.

  Pharmacological research 20050101

• Could cholinesterase inhibitors and memantine alleviate HIV dementia?

  Journal of acquired immune deficiency syndromes (1999) 20050101

• The emperor has no clothes: dementia treatment on the eve of the aging era.

  Journal of the American Geriatrics Society 20050101

• Memantine as a neuroprotective treatment in schizophrenia.

  The British journal of psychiatry : the journal of mental science 20050101

• Memantine: a pharmacoeconomic review of its use in moderate-to-severe Alzheimer's disease.

  PharmacoEconomics 20050101

• Another perspective on the memantine graphs: clinical vs. statistical significance.

  Medicine and health, Rhode Island 20050101

• Memantine: targeting glutamate excitotoxicity in Alzheimer's disease and other dementias.

  American journal of Alzheimer's disease and other dementias 20050101

• Effect of NMDA receptor antagonists on behavioral impairment induced by chronic treatment with dexamethasone.

  Pharmacological reports : PR 20050101

• The NMDA antagonist memantine affects training induced motor cortex plasticity--a study using transcranial magnetic stimulation.

  BMC neuroscience 20050101

• Current status and future promise of pharmacotherapeutic strategies for Alzheimer's disease.

  Journal of the American Medical Directors Association 20050101

• [Music and art therapy--a taboo topic in therapy of dementia?].

  Krankenpflege Journal 20050101

• [Effectiveness and tolerance of memantine in general practice].

  Krankenpflege Journal 20050101

• Health utilities in Alzheimer's disease and implications for cost-effectiveness analysis.

  PharmacoEconomics 20050101

• NMDA receptor antagonism does not inhibit induction of ischemic tolerance in gerbil brain in vivo.

  Neurotoxicity research 20050101

• Drug therapy of dementia in elderly patients. A review.

  Nordic journal of psychiatry 20050101

• [Mitochondria as the target for neuroprotectors].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20050101

• [Use of acetylcholinesterase inhibitors and memantine in Alzheimer-type dementia].

  Revista espanola de salud publica 20050101

• Guidelines for the treatment of Alzheimer's disease from the Italian Association of Psychogeriatrics.

  Drugs & aging 20050101

• [Also consider non-cognitive disorders].

  Krankenpflege Journal 20050101

• A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.

  NeuroImage 20041201

• Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders.

  Journal of Alzheimer's disease : JAD 20041201

• Dementia.

  Clinical evidence 20041201

• Vascular dementia. Advances in nosology, diagnosis, treatment and prevention.

  Panminerva medica 20041201

• Efficacy and tolerability of memantine in the treatment of dementia.

  The American journal of geriatric pharmacotherapy 20041201

• Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease.

  The Journal of pharmacology and experimental therapeutics 20041101

• Memantine for dementia.

  The Cochrane database of systematic reviews 20041018

• Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.

  British journal of pharmacology 20041001

• Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions.

  European journal of clinical pharmacology 20041001

• The place of memantine in the treatment of Alzheimer's disease: a number needed to treat analysis.

  International journal of geriatric psychiatry 20041001

• Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil.

  The Annals of pharmacotherapy 20040901

• Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain.

  Neuropharmacology 20040901

• Memantine approved to treat moderate to severe Alzheimer's disease.

  Current neurology and neuroscience reports 20040901

• [Memantine: a therapeutic drug for Alzheimer's disease and the comparison with MK-801].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040901

• The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.

  Expert opinion on drug safety 20040901

• Effects of NMDA receptor antagonists (MK-801 and memantine) on the acquisition of morphine-induced conditioned place preference in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20040901

• Memantine: pharmacological properties and clinical uses.

  Neurology India 20040901

• Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040811

• [Diagnosis and treatment of vascular dementia].

  Praxis 20040811

• Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.

  Neuropharmacology 20040801

• Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures.

  Investigative ophthalmology & visual science 20040801

• Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures.

  Investigative ophthalmology & visual science 20040801

• Cognition and immunity; antibody impairs memory.

  Immunity 20040801

• Memantine hydrochloride: pharmacological and clinical profile.

  Drugs of today (Barcelona, Spain : 1998) 20040801

• [Role of magnesium ions on the regulation of NMDA receptor--a pharmacopathology of memantine].

  Clinical calcium 20040801

• Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation.

  Neuroscience letters 20040722

• Alzheimer's disease.

  The New England journal of medicine 20040701

• What is the rationale for new treatment strategies in Alzheimer's disease?

  CNS spectrums 20040701

• Understanding the latest advances in pharmacologic interventions for Alzheimer's disease.

  CNS spectrums 20040701

• Effects of NMDA receptor channel blockers, MK-801 and memantine, on locomotor activity and tolerance to delay of reward in Wistar-Kyoto and spontaneously hypertensive rats.

  Behavioural pharmacology 20040701

• The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats.

  Behavioural pharmacology 20040701

• Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.

  Anesthesia and analgesia 20040701

• [New informations on medical treatment for normal-tension glaucoma].

  Nippon Ganka Gakkai zasshi 20040701

• [Psychotropic drug treatment in dementia disorders].

  Deutsche medizinische Wochenschrift (1946) 20040618

• [Effect of drugs against dementia].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20040617

• [Memantine can relieve certain symptoms in Parkinson disease. Improvement achieved in two out of three described cases with dyskinesia and cognitive failure].

  Lakartidningen 20040603

• Identification of genes regulated by memantine and MK-801 in adult rat brain by cDNA microarray analysis.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040601

• New platinum(IV) complex with adamantylamine ligand as a promising anti-cancer drug: comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum(IV) complexes.

  Anti-cancer drugs 20040601

• Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population.

  International journal of geriatric psychiatry 20040601

• NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease.

  Geriatrics 20040601

• Dementia.

  Clinical evidence 20040601

• Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.

  FEBS letters 20040521

• Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.

  Bioorganic & medicinal chemistry letters 20040517

• Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.

  Stroke 20040501

• American Chemical Society--227th Annual Meeting. NMDA receptor. 28 March - 1 April 2004, Anaheim, CA, USA.

  IDrugs : the investigational drugs journal 20040501

• Memantine enhances autonomy in moderate to severe Alzheimer's disease.

  International journal of geriatric psychiatry 20040501

• Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.

  Behavioural pharmacology 20040501

• Pharmacotherapeutic approaches to the treatment of Alzheimer's disease.

  Clinical therapeutics 20040501

• Memantine for patients with Alzheimer disease.

  JAMA 20040414

• [Memantine (Ebixa), glutaminergic modulator].

  Revue medicale de Bruxelles 20040401

• Memantine (Namenda) for moderate to severe Alzheimer's disease.

  American family physician 20040315

• Questions & answers. We've been told that my wife has multi-infarct dementia and that the new drug memantine may help. How is her condition different from Alzheimer's disease, and what could memantine do for her?

  The Harvard mental health letter 20040301

• Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome.

  Pharmacopsychiatry 20040301

• Acute effects of memantine in combination with alcohol in moderate drinkers.

  Psychopharmacology 20040201

• A placebo-controlled randomized crossover trial of the N-methyl-D-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain.

  Anesthesia and analgesia 20040201

• Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee (Apis mellifera).

  Pharmacology, biochemistry, and behavior 20040201

• Vascular cognitive impairment.

  Stroke 20040201

• No nerve growth factor response to treatment with memantine in adult rats.

  Journal of neural transmission (Vienna, Austria : 1996) 20040201

• FDA approves groundbreaking Alzheimer's drug.

  Provider (Washington, D.C.) 20040201

• Academic highlights: emerging therapeutic strategies in Alzheimer's disease.

  The Journal of clinical psychiatry 20040201

• Drug for moderate to advanced Alzheimer's approved.

  Mayo Clinic health letter (English ed.) 20040201

• [Protective effect of memantine on N-methyl-D-aspartate receptor in dichlorvos-poisoned rat brain].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040201

• Memantine hydrochloride.

  Nature reviews. Drug discovery 20040201

• Scopolamine given pre-Trial 1 prevents the one-trial tolerance phenomenon in the elevated plus-maze Trial 2.

  Behavioural pharmacology 20040201

• [New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].

  Gastroenterologia y hepatologia 20040201

• Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.

  JAMA 20040121

• Adenosine A2A receptor mRNA expression is increased in rat striatum and nucleus accumbens after memantine administration.

  Brain research. Molecular brain research 20040105

• Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine.

  Cell death and differentiation 20040101

• Evolutionary rather than revolutionary progress in dementia.

  The Lancet. Neurology 20040101

• NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia.

  Current pharmaceutical design 20040101

• Society of neuroscience-33rd annual meeting: metabotropic glutamate receptors.

  IDrugs : the investigational drugs journal 20040101

• Update on dementia medications for 2004.

  Geriatric nursing (New York, N.Y.) 20040101

• Memantine: an antiglutamatergic option for dementia.

  American journal of Alzheimer's disease and other dementias 20040101

• [Mémantine (Ebixa): a new therapeutic strategy for the treatment of moderate to severe forms of Alzheimer's disease].

  L'Encephale 20040101

• First drug for moderate-to-severe Alzheimer's.

  FDA consumer 20040101

• The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation.

  Neuroscience 20040101

• Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo.

  Neurotoxicity research 20040101

• Effect of memantine on the levels of glial cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated alzheimer's disease model.

  Neuroscience 20040101

• Memantine in moderate-to-severe Alzheimer disease evidence and ethics based?

  Alzheimer disease and associated disorders 20040101

• What are the treatment options for patients with severe Alzheimer's disease?

  CNS drugs 20040101

• Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer's disease.

  Dementia and geriatric cognitive disorders 20040101

• Cost effectiveness of memantine in Alzheimer's disease: an analysis based on a probabilistic Markov model from a UK perspective.

  Drugs & aging 20040101

• [The clinical relevance of memantine use].

  Psychiatria polska 20040101

• The N-methyl-D-aspartate antagonist memantine retards progression of Huntington's disease.

  Journal of neural transmission. Supplementum 20040101

• Memantine: a new approach to Alzheimer's disease.

  Perspectives in psychiatric care 20040101

• Why do many NMDA antagonists fail, while others are safe and effective at blocking excitotoxicity associated with dementia and acute injury?

  American journal of Alzheimer's disease and other dementias 20040101

• Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.

  NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 20040101

• Treatment of Alzheimer's disease: current and future therapeutic approaches.

  Reviews in neurological diseases 20040101

• Memantine attenuates the increase in striatal preproenkephalin mRNA expression and development of haloperidol-induced persistent oral dyskinesias in rats.

  Brain research 20031224

• Into the darkness of the mind.

  Newsweek 20031208

• Anxiolytic-like effects of NMDA/glycine-B receptor ligands are abolished during the elevated plus-maze trial 2 in rats.

  Psychopharmacology 20031201

• Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus.

  The Journal of physiology 20031201

• Evaluation of memantine for the treatment of Alzheimer's disease.

  Expert opinion on pharmacotherapy 20031201

• Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors.

  British journal of pharmacology 20031201

• Erotomania variants in dementia.

  Journal of geriatric psychiatry and neurology 20031201

• New Alzheimer's drug approved.

  Health news (Waltham, Mass.) 20031201

• Alzheimer's disease: a progress report, Part II. The continuing search for treatments and persistent hopes for prevention.

  The Harvard mental health letter 20031201

• Memantine: new preparation. Poor evaluation and uncertain benefit in Alzheimer's disease.

  Prescrire international 20031201

• [Not a subject. Speech and swallowing disorders in dementia].

  MMW Fortschritte der Medizin 20031113

• [Dementia].

  Fortschritte der Neurologie-Psychiatrie 20031101

• Memantine (Ebixa) in the later stages of dementia.

  Hospital medicine (London, England : 1998) 20031101

• Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons.

  Bulletin of experimental biology and medicine 20031101

• [Memantine for the treatment of dementia].

  Nederlands tijdschrift voor geneeskunde 20031025

• Editorial comment--How to treat vascular dementia?

  Stroke 20031001

• Is memantine a breakthrough in the treatment of moderate-to-severe Alzheimer's disease?

  Expert opinion on pharmacotherapy 20031001

• Memantine for dementia?

  Drug and therapeutics bulletin 20031001

• Binding of memantine to melanin: influence of type of melanin and characteristics.

  Pharmaceutical research 20031001

• Memantine presents different effects from MK-801 in motivational and physical signs of morphine withdrawal.

  Behavioural brain research 20030915

• Memantine for Alzheimer's disease.

  The Medical letter on drugs and therapeutics 20030915

• NMDA-mediated mechanisms in cortical excitability changes after limb amputation.

  Acta neurologica Scandinavica 20030901

• Treatment of Alzheimer's disease: current status and new perspectives.

  The Lancet. Neurology 20030901

• The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence.

  International journal of geriatric psychiatry 20030901

• Treating the full spectrum of dementia with memantine.

  International journal of geriatric psychiatry 20030901

• Memantine: update on the current evidence.

  International journal of geriatric psychiatry 20030901

• Does this patient have Alzheimer disease? Diagnosing and treating dementia.

  Cleveland Clinic journal of medicine 20030901

• Diagnosis and management of Alzheimer's disease.

  Connecticut medicine 20030901

• [Antibodies, antihypertensive drugs, antioxidants. Can they prevent Alzheimer disease?].

  MMW Fortschritte der Medizin 20030821

• Memantine in moderate-to-severe Alzheimer's disease.

  The New England journal of medicine 20030807

• Memantine for the treatment of dementia.

  The Lancet. Neurology 20030801

• Treating the dementia of Iris with a cholinesterase inhibitor.

  International journal of geriatric psychiatry 20030801

• [Glutamate antagonists for treatment of neuropathic pain].

  Schmerz (Berlin, Germany) 20030801

• [Drug therapy of Alzheimer dementia].

  Ugeskrift for laeger 20030714

• Pharmacological modulation of perceptual learning and associated cortical reorganization.

  Science (New York, N.Y.) 20030704

• Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum.

  Neuroscience letters 20030612

• [Early treatment with anti-dementia drugs when possible. These signs reveal Alzheimer disease].

  MMW Fortschritte der Medizin 20030605

• A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.

  Journal of magnetic resonance imaging : JMRI 20030601

• [Memantine].

  Neurologia (Barcelona, Spain) 20030601

• Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain--results of a randomized double-blinded, placebo-controlled trial.

  Pain 20030601

• [Memantine brakes Alzheimer's dementia. The NMDA antagonist is effective in severe cases, too].

  MMW Fortschritte der Medizin 20030526

• [Current therapy of patients with dementia].

  MMW Fortschritte der Medizin 20030526

• [Anti-dementia therapy pays at every stage of the disease. Patients with Alzheimer's disease stay all-day fit longer].

  MMW Fortschritte der Medizin 20030526

• NMDA receptor activity and the transmission of sensory input into motor output in introverts and extraverts.

  The Quarterly journal of experimental psychology. B, Comparative and physiological psychology 20030501

• Effects of memantine, an NMDA receptor antagonist, on place preference conditioned with drug and nondrug reinforcers in mice.

  Behavioural pharmacology 20030501

• Cortical reorganisation and chronic pain: implications for rehabilitation.

  Journal of rehabilitation medicine 20030501

• [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20030501

• Development of a liquid chromatography-mass spectrometric method for measuring the binding of memantine to different melanins.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425

• Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.

  European journal of pharmacology 20030411

• Memantine in moderate-to-severe Alzheimer's disease.

  The New England journal of medicine 20030403

• Comments on the NMDA antagonist memantine.

  Methods and findings in experimental and clinical pharmacology 20030401

• Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage.

  Survey of ophthalmology 20030401

• The regulatory effect of memantine on expression and synthesis of heat shock protein 70 gene in neonatal rat models with cerebral hypoxic ischemia.

  Chinese medical journal 20030401

• Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.

  International clinical psychopharmacology 20030301

• Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.

  Neuroscience and behavioral physiology 20030301

• The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.

  Neuroscience and behavioral physiology 20030301

• [Prevention of dementias: state of the art].

  Deutsche medizinische Wochenschrift (1946) 20030227

• Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats.

  Psychopharmacology 20030201

• Alzheimer's disease: emerging noncholinergic treatments.

  Geriatrics 20030201

• [Treatment with NMDA antagonist controls neuron death. Even in severe dementia it is not too late].

  MMW Fortschritte der Medizin 20030116

• Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice.

  Psychopharmacology 20030101

• Memantine for dementia.

  The Cochrane database of systematic reviews 20030101

• [The challenge of Alzheimer dementia].

  Pharmazie in unserer Zeit 20030101

• Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.

  European journal of pain (London, England) 20030101

• Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease.

  PharmacoEconomics 20030101

• Molecule of the month. Memantine hydrochloride.

  Drug news & perspectives 20030101

• Memantine.

  Drugs & aging 20030101

• Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency.

  Bulletin of experimental biology and medicine 20030101

• The glutamatergic system and Alzheimer's disease: therapeutic implications.

  CNS drugs 20030101

• A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome.

  Medicinski arhiv 20030101

• Memantine for dementia.

  The Cochrane database of systematic reviews 20030101

• Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions.

  European journal of medicinal chemistry 20030101

• The search for better noncholinergic treatment options for Alzheimer's disease.

  The Journal of clinical psychiatry 20030101

• Current treatment for Alzheimer disease and future prospects.

  Alzheimer disease and associated disorders 20030101

• The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

  CNS drug reviews 20030101

• Alzheimer's disease and the glutamate NMDA receptor.

  Psychopharmacology bulletin 20030101

• [Mechanisms of action of Alzheimer medications].

  Duodecim; laaketieteellinen aikakauskirja 20030101

• FDA approves memantine drug for treating AD.

  American journal of Alzheimer's disease and other dementias 20030101

• Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats.

  Polish journal of pharmacology 20030101

• Memantine in vascular dementia.

  International psychogeriatrics 20030101

• Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

  Brain research 20021220

• [Early diagnosis and treatment of Alzheimer's disease. Implementation in the doctor's office].

  Fortschritte der Medizin. Originalien 20021205

• Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity.

  Archives of toxicology 20021201

• Effects of the NMDA antagonist memantine on human methamphetamine discrimination.

  Psychopharmacology 20021201

• Neuroprotective effect of memantine in different retinal injury models in rats.

  Journal of glaucoma 20021201

• Memantine offers new possibilities for the treatment of VaD.

  The Lancet. Neurology 20021201

• A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500).

  International clinical psychopharmacology 20021101

• [Anti-dementia drugs for Alzheimer disease in present and future].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101

• Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by non-competitive NMDA antagonists.

  Journal of neuroscience methods 20021030

• NMDA receptor antagonists to characterize rat renal organic cation transporter function.

  European journal of pharmacology 20020927

• Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.

  Vision research 20020901

• New therapies. New Alzheimer's treatments that may ease the mind.

  Science (New York, N.Y.) 20020823

• Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.

  European journal of pharmacology 20020823

• [Case report. Dementia with apathy].

  MMW Fortschritte der Medizin 20020808

• Modulation of blood-brain barrier dysfunction and neurological deficits during acute experimental allergic encephalomyelitis by the N-methyl-D-aspartate receptor antagonist memantine.

  The Journal of pharmacology and experimental therapeutics 20020701

• Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

  Stroke 20020701

• [Use of memantine in progressive glaucoma. Case report].

  Klinische Monatsblatter fur Augenheilkunde 20020701

• Treatment of spasticity.

  Spinal cord 20020601

• Trends in neuroprotection.

  Archivos de la Sociedad Espanola de Oftalmologia 20020601

• Phenytoin blocks retinal ganglion cell death after partial optic nerve crush.

  Experimental eye research 20020601

• Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia.

  Korean journal of ophthalmology : KJO 20020601

• Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the reflex responses to distension of the rat urinary bladder.

  Anesthesiology 20020601

• Ketamine, an N-methyl-D-aspartate receptor antagonist, inhibits the spinal neuronal responses to distension of the rat urinary bladder.

  Anesthesiology 20020601

• Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials.

  Anesthesiology 20020501

• Memantine. Merz.

  Current opinion in investigational drugs (London, England : 2000) 20020501

• Quantitative analysis of memantine in human plasma by gas chromatography/negative ion chemical ionization/mass spectrometry.

  Journal of mass spectrometry : JMS 20020501

• Memantine does not block antiaggressive effects of morphine in mice.

  Behavioural pharmacology 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.

  Molecular pharmacology 20020301

• [Geriatric assessment in 3 steps. Often mental decline is not correctly assessed].

  MMW Fortschritte der Medizin 20020221

• PET studies of 18F-memantine in healthy volunteers.

  Nuclear medicine and biology 20020201

• Electrophoretic behavior of adamantane derivatives possessing antiviral activity and their determination by capillary zone electrophoresis with indirect detection.

  Electrophoresis 20020101

• Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea.

  Advances in oto-rhino-laryngology 20020101

• New approaches to clinical trials in vascular dementia: memantine in small vessel disease.

  Cerebrovascular diseases (Basel, Switzerland) 20020101

• [The agony and (rational) alternative. Recommendations of the drug commission on antidementia agents].

  Pharmazie in unserer Zeit 20020101

• The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disruptions in Ca2+ homeostasis.

  Neuroscience and behavioral physiology 20020101

• Non-cholinergic strategies for treating and preventing Alzheimer's disease.

  CNS drugs 20020101

• Glutamate receptors as a target for Alzheimer's disease--are clinical results supporting the hope?

  Journal of neural transmission. Supplementum 20020101

• Defining the role of the caregiver in Alzheimer's disease treatment.

  Drugs & aging 20020101

• [Prospects for neuroprotective glaucoma therapy].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

• Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

  Journal of neuroscience research 20010915

• Glutamate release promotes growth of malignant gliomas.

  Nature medicine 20010901

• The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain.

  Molecular and cellular neurosciences 20010901

• Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required.

  Veterinary ophthalmology 20010901

• Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.

  Brain research 20010817

• Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol.

  Neuroscience letters 20010817

• The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humans.

  Psychopharmacology 20010801

• Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells.

  Molecular pharmacology 20010701

• The in vivo relevance of the varied channel-blocking properties of uncompetitive NMDA antagonists: tests on spinal neurones.

  Neuropharmacology 20010701

• The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.

  Neuroscience letters 20010622

• Private investigations.

  Nature 20010510

• [Drug therapy of dementia. Improving cognitive performance].

  MMW Fortschritte der Medizin 20010503

• Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men. a randomized, double-blind, placebo-controlled trial.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

• The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model.

  The Journal of thoracic and cardiovascular surgery 20010501

• The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801.

  Neuropharmacology 20010501

• Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey.

  Survey of ophthalmology 20010501

• Eliciting paresthesias for peripheral nerve block: a harmful clinical standard?

  Anesthesia and analgesia 20010301

• Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy.

  Pain 20010301

• [Neuroprotection. Bases and possibilities of a future clinical use].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20010301

• Drugs for treatment of Alzheimer's disease.

  International journal of clinical practice 20010301

• Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.

  European journal of pharmacology 20010209

• Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex.

  Pharmacology & toxicology 20010201

• Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.

  Neuropharmacology 20010101

• Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.

  Anesthesiology 20010101

• Memantine treatment in alcohol dementia: rapid PET changes and clinical course.

  European neurology 20010101

• Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans.

  Learning & memory (Cold Spring Harbor, N.Y.) 20010101

• Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice.

  Journal of neural transmission (Vienna, Austria : 1996) 20010101

• The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.

  Bulletin of experimental biology and medicine 20010101

• [Current strategies of pathogenetic therapy of Alzheimer's disease].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101

• If only we can stop the progression...

  American journal of Alzheimer's disease and other dementias 20010101

• NMDA antagonists inhibit the development of ethanol dependence in rats.

  Polish journal of pharmacology 20010101

• Effects of the NMDA receptor channel blockers memantine and MRZ 2/579 on morphine withdrawal-facilitated aggression in mice.

  Psychopharmacology 20000501

• Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine.

  Annals of neurology 20000201

• Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex.

  Neuropharmacology 20000128

• [A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20000101

• Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability.

  Amino acids 20000101

• Anticonvulsant efficacy of N-methyl-D-aspartate antagonists against convulsions induced by cocaine.

  The Journal of pharmacology and experimental therapeutics 19990501

• The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease.

  International journal of geriatric psychiatry 19990101

• Anticonvulsants for soman-induced seizure activity.

  Journal of biomedical science 19990101

• How to overcome resistance of influenza A viruses against adamantane derivatives.

  Antiviral research 19980201

• Inhibition by memantine of the development of persistent oral dyskinesias induced by long-term haloperidol treatment of rats.

  British journal of pharmacology 19961001

• Are NMDA antagonistic properties relevant for antiparkinsonian-like activity in rats?--case of amantadine and memantine.

  Journal of neural transmission. Parkinson's disease and dementia section 19940101

• gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine.

  European journal of pharmacology 19920701

• Pharmacotoxic psychosis after memantine in Parkinson's disease.

  Lancet (London, England) 19911019

• Susceptibility of primary human glial fibrillary acidic protein-positive brain cells to human immunodeficiency virus infection in vitro: anti-HIV activity of memantine.

  AIDS research and human retroviruses 19910101

• Methyl parathion acute toxicity: prophylaxis and therapy with memantine and atropine.

  Archives internationales de pharmacodynamie et de therapie 19900101

• [Memantine and neurogenic bladder disorders within the bounds of spastic conditions].

  Arzneimittel-Forschung 19820101