19983-44-9 | 1,1-Dioxide-6-nitro-benzo[b]thiophene

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
10mg	98%	in stock	$14.00	$10.00
25mg	98%	in stock	$22.00	$16.00
50mg	98%	in stock	$34.00	$24.00
100mg	98%	in stock	$45.00	$32.00
250mg	95%	in stock	$81.00	$57.00
500mg	95%	in stock	$118.00	$83.00
1g	95%	in stock	$168.00	$118.00
5g	96%	in stock	$573.00	$402.00
10g	96%	in stock	$946.00	$662.00

Description

• Catalog Number: AB09174
• Chemical Name: 1,1-Dioxide-6-nitro-benzo[b]thiophene
• CAS Number: 19983-44-9
• Molecular Formula: C8H5NO4S
• Molecular Weight: 211.1946
• MDL Number: MFCD00173799
• SMILES: [O-][N+](=O)c1ccc2c(c1)S(=O)(=O)C=C2

Computed Properties

• Complexity: 375
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 4
• XLogP3: 0.7

Literature

• The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20171201

• Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

  Toxicology and applied pharmacology 20171101

• Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.

  Neoplasia (New York, N.Y.) 20150701

• Noncanonical STAT3 activation regulates excess TGF-β1 and collagen I expression in muscle of stricturing Crohn's disease.

  Journal of immunology (Baltimore, Md. : 1950) 20150401

• Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.

  The FEBS journal 20150301

• Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.

  The Journal of biological chemistry 20140502

• Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.

  Cancer letters 20140501

• JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.

  Cell cycle (Georgetown, Tex.) 20130101

• Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level.

  Histochemistry and cell biology 20121201

• Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10.

  The Journal of nutritional biochemistry 20121101

• HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.

  Cancer biology & therapy 20120701

• JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.

  Toxicological sciences : an official journal of the Society of Toxicology 20120601

• STAT3 does not regulate acute liver injury after ischemia/reperfusion.

  The Journal of surgical research 20111201

• STAT3 is necessary for proliferation and survival in colon cancer-initiating cells.

  Cancer research 20111201

• Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.

  Circulation research 20111111

• XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.

  Apoptosis : an international journal on programmed cell death 20110501

• STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?

  International journal of cancer 20110215

• Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart.

  British journal of pharmacology 20110201

• Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion.

  Basic research in cardiology 20101101

• Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis.

  European journal of immunology 20100901

• Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).

  Biology of the cell 20090923

• STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.

  Molecular immunology 20090501

• Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.

  Journal of molecular endocrinology 20090401

• Regulating RISK: a role for JAK-STAT signaling in postconditioning?

  American journal of physiology. Heart and circulatory physiology 20081001

• Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

  Chemistry & biology 20061101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419