20069-09-4 | Piperlongumine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
25mg	98%	in stock	$50.00	$35.00
100mg	98%	in stock	$69.00	$48.00
250mg	98%	in stock	$145.00	$101.00
500mg	98%	in stock	$236.00	$165.00
1g	98%	in stock	$368.00	$257.00
5g	98%	in stock	$1,099.00	$769.00

Description

• Catalog Number: AB09850
• Chemical Name: Piperlongumine
• CAS Number: 20069-09-4
• Molecular Formula: C17H19NO5
• Molecular Weight: 317.3365
• MDL Number: MFCD00075706
• SMILES: COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(c1OC)OC

Computed Properties

• Complexity: 473
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• XLogP3: 2.1

Literature

• Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting Akt pathway in human lung cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101

• Piperlongumine is a novel nuclear export inhibitor with potent anticancer activity.

  Chemico-biological interactions 20150725

• Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling.

  Biochemical and biophysical research communications 20121019

• A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6.

  PloS one 20120101

• Simultaneous UFLC-ESI-MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: application to pharmacokinetic studies in rats.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111001

• Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

  Nature 20110714

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.

  Toxicology in vitro : an international journal published in association with BIBRA 20090901

• Antihyperlipidemic compounds from the fruit of Piper longum L.

  Phytotherapy research : PTR 20090801

• Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells.

  The Chinese journal of physiology 20090630

• Antiplatelet activities of newly synthesized derivatives of piperlongumine.

  Phytotherapy research : PTR 20080901

• In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species.

  Journal of applied toxicology : JAT 20080701

• Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.

  Bioorganic & medicinal chemistry letters 20080601

• Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase.

  Archives of pharmacal research 20080601

• [Antiatherogenic effect of piperlonguminine on experimental atherosclerosis in rabbits].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

• Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist.

  European journal of pharmacology 20070910

• Inhibition of beta-amyloid precursor protein gene in SK-N-SH cells by piperlonguminine/dihydropiperlonguminine components separated from Chinese herbal medicine Futokadsura stem.

  The Chinese journal of physiology 20070831

• Inhibitory effect of ethanol extract of Piper longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor.

  Biological & pharmaceutical bulletin 20070701

• Suppression of ochratoxin biosynthesis by naturally occurring alkaloids.

  Food additives and contaminants 20070401

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.

  Pigment cell research 20060201

• Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells.

  Planta medica 20041201