20315-68-8 | 6-Methoxy-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$8.00	$5.00
250mg	95%	in stock	$9.00	$7.00
1g	95%	in stock	$31.00	$22.00
5g	95%	in stock	$154.00	$108.00

Description

• Catalog Number: AB04391
• Chemical Name: 6-Methoxy-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole
• CAS Number: 20315-68-8
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.2524
• MDL Number: MFCD00012071
• SMILES: COc1ccc2c(c1)c1CCNCc1[nH]2

Computed Properties

• Complexity: 234
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.5

Literature

• Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

  Bioorganic & medicinal chemistry letters 20120415

• Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats.

  Toxins 20110201

• In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline.

  Journal of pineal research 20100801

• Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.

  International journal of molecular sciences 20100101

• Pinoline may be used as a probe for CYP2D6 activity.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Pinoline and N-acetylserotonin reduce glutamate-induced lipid peroxidation in retinal homogenates.

  Neuroscience letters 20070202

• 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.

  Bioorganic & medicinal chemistry letters 20061115

• Protective effect of melatonin and pinoline on nitric oxide-induced lipid and protein peroxidation in rat brain homogenates.

  Neuroscience letters 20060911

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Antioxidant activity of melatonin and a pinoline derivative on linoleate model system.

  Journal of pineal research 20050801

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Effects of vitamin E and pinoline on retinal lipid peroxidation.

  Clinical & experimental optometry 20040501

• Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

  Bioorganic & medicinal chemistry letters 20040223

• Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

  Bioorganic & medicinal chemistry letters 20040223

• Binding of beta-carbolines at 5-HT(2) serotonin receptors.

  Bioorganic & medicinal chemistry letters 20031215

• Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

  European journal of pharmacology 20031215

• Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

  Pharmacogenetics 20030601

• Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20030101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419