2051-62-9 | 4-Chlorobiphenyl

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$33.00	$23.00
5g	95%	in stock	$102.00	$71.00
25g	95%	in stock	$369.00	$259.00
100g	95%	in stock	$1,132.00	$793.00

Description

• Catalog Number: AB05888
• Chemical Name: 4-Chlorobiphenyl
• CAS Number: 2051-62-9
• Molecular Formula: C12H9Cl
• Molecular Weight: 188.65286
• MDL Number: MFCD00013640
• SMILES: Clc1ccc(cc1)c1ccccc1
• NSC Number: 37066

Computed Properties

• Complexity: 141
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Rotatable Bond Count: 1
• XLogP3: 4.6

Literature

• Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

  Archives of toxicology 20160201

• Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes.

  Toxicology letters 20150318

• Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1.

  Chemico-biological interactions 20140405

• Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin.

  Environmental health perspectives 20130601

• [4-chlorobiphenyl and 4-chlorobenzoic acid biodegradation by Rhodococcus ruber P25].

  Mikrobiologiia 20120101

• Antioxidant compounds improved PCB-degradation by Burkholderia xenovorans strain LB400.

  Enzyme and microbial technology 20111210

• Are luminescent bacteria suitable for online detection and monitoring of toxic compounds in drinking water and its sources?

  Analytical and bioanalytical chemistry 20110501

• Humic acid and metal ions accelerating the dechlorination of 4-chlorobiphenyl by nanoscale zero-valent iron.

  Journal of environmental sciences (China) 20110101

• New hydroxylated metabolites of 4-monochlorobiphenyl in whole poplar plants.

  Chemistry Central journal 20110101

• An efficient organocatalytic method for constructing biaryls through aromatic C-H activation.

  Nature chemistry 20101201

• Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.

  Environment international 20101101

• Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites.

  Environment international 20101101

• 2-(4-Chlorophenyl)benzo-1,4-quinone induced ROS-signaling inhibits proliferation in human non-malignant prostate epithelial cells.

  Environment international 20101101

• Polyploidy-induction by dihydroxylated monochlorobiphenyls: structure-activity-relationships.

  Environment international 20101101

• 3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats.

  Environment international 20101101

• 4'-Chloro-biphenyl-3-yl 2,2,2-trichloro-ethyl sulfate.

  Acta crystallographica. Section E, Structure reports online 20100901

• Hydroxylated metabolites of 4-monochlorobiphenyl and its metabolic pathway in whole poplar plants.

  Environmental science & technology 20100515

• The complete genome sequence of Cupriavidus metallidurans strain CH34, a master survivalist in harsh and anthropogenic environments.

  PloS one 20100101

• Computational framework for predictive biodegradation.

  Biotechnology and bioengineering 20091215

• Direct inhibition of ERK1/2 phosphorylation as a possible mechanism for the antiproliferative action of 3,4-diOH-PCB3 in the MCF-7 cell line.

  Toxicology letters 20091028

• Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells.

  Toxicology and applied pharmacology 20091015

• Kinetic study of hydrodechlorination of chlorobiphenyl with polymer-stabilized palladium nanoparticles in supercritical carbon dioxide.

  The journal of physical chemistry. A 20090910

• Exploring QSAR and QAAR for inhibitors of cytochrome P450 2A6 and 2A5 enzymes using GFA and G/PLS techniques.

  European journal of medicinal chemistry 20090501

• Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase.

  Chemical research in toxicology 20090101

• Novel Tn4371-ICE like element in Ralstonia pickettii and genome mining for comparative elements.

  BMC microbiology 20090101

• Reductive Dechlorination of Polychlorinated Biphenyls and Dibenzo-p-Dioxins in an Enrichment Culture Containing Dehalobacter Species.

  Microbes and environments 20090101

• 4'-Chloro-biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate.

  Acta crystallographica. Section E, Structure reports online 20081201

• Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells.

  Free radical biology & medicine 20081015

• Microbial transformation and degradation of polychlorinated biphenyls.

  Environmental pollution (Barking, Essex : 1987) 20080901

• A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

• Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies.

  Chemical research in toxicology 20080721

• Xenobiotic geometry and media pH determine cytotoxicity through solubility.

  Chemical research in toxicology 20080501

• Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats.

  Environmental toxicology and pharmacology 20080301

• Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells.

  Environmental toxicology and pharmacology 20080301

• The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.

  BMC genomics 20080101

• Degradation and mineralization of 2-chloro-, 3-chloro- and 4-chlorobiphenyl by a newly characterized natural bacterial strain isolated from an electrical transformer fluid-contaminated soil.

  Journal of environmental sciences (China) 20080101

• Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range.

  Biochemistry 20071218

• Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20071101

• Expression of bacterial biphenyl-chlorobiphenyl dioxygenase genes in tobacco plants.

  Biotechnology and bioengineering 20070615

• Pathways and products of the degradation of PCBs by the sodium dispersion method.

  Chemosphere 20070601

• Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes.

  Chemico-biological interactions 20070501

• Electrocatalytic hydrodechlorination of 4-chlorobiphenyl in aqueous solution using palladized nickel foam cathode.

  Chemosphere 20070401

• Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3).

  Acta crystallographica. Section B, Structural science 20070401

• Characterization of two biphenyl dioxygenases for biphenyl/PCB degradation in A PCB degrader, Rhodococcus sp. strain RHA1.

  Bioscience, biotechnology, and biochemistry 20070401

• 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats.

  Carcinogenesis 20070201

• Response to (chloro)biphenyls of the polychlorobiphenyl-degrader Burkholderia xenovorans LB400 involves stress proteins also induced by heat shock and oxidative stress.

  FEMS microbiology letters 20070201

• [Estimation of bioconcentration factor of benzene derivatives].

  Ying yong sheng tai xue bao = The journal of applied ecology 20061201

• Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary.

  Toxicology letters 20061025

• Oxidative ring cleavage of low chlorinated biphenyl derivatives by fungi leads to the formation of chlorinated lactone derivatives.

  Chemosphere 20060701

• In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity.

  Toxicology letters 20060701

• Characterization of the PCB substrate range of microbial dechlorination process LP.

  Environmental science & technology 20050901

• Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

  Journal of medicinal chemistry 20050602

• Elucidation of degradation mechanism of dioxins during mechanochemical treatment.

  Environmental science & technology 20050515

• Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme.

  Journal of medicinal chemistry 20050127

• Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture.

  Reproductive toxicology (Elmsford, N.Y.) 20050101

• Effect of sorbate planarity on environmental black carbon sorption.

  Environmental science & technology 20040701

• Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.

  Toxicological sciences : an official journal of the Society of Toxicology 20040501

• Construction of transformant reporters carrying fused genes using pcbC promoter of Pseudomonas sp DJ-12 for detection of aromatic pollutants.

  Environmental monitoring and assessment 20040301

• [Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030501

• Binding of polychlorinated biphenyls/metabolites to hemoglobin.

  Toxicology letters 20030430

• DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes.

  Toxicology and applied pharmacology 20030415

• DNA adduction by polychlorinated biphenyls: adducts derived from hepatic microsomal activation and from synthetic metabolites.

  Chemico-biological interactions 20020220

• Sonochemical desorption and destruction of 4-chlorobiphenyl from synthetic sediments.

  Environmental science & technology 20020115

• A laboratory pilot study of thermal decontamination of soils polluted by PCBs. Comparison with thermogravimetric analysis.

  Waste management (New York, N.Y.) 20020101

• Distribution and macromolecular binding of benzo[a]pyrene and two polychlorinated biphenyl congeners in female mice.

  Chemico-biological interactions 20010928

• Adaptive and cross-protective responses of Pseudomonas sp. DJ-12 to several aromatics and other stress shocks.

  Current microbiology 20010901

• Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress.

  Biochemical pharmacology 20010801

• Dechlorination of polychlorobiphenyls using NaBH(4) and NaBH(4)/LiCl at 120-310 degrees C in glyme solvents.

  Journal of hazardous materials 20010420

• 2,4,4'-trichlorobiphenyl increases STAT5 transcriptional activity.

  Molecular carcinogenesis 20010401

• Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver.

  Toxicology and applied pharmacology 20010301

• Development of a Rhodococcus recombinant strain for degradation of products from anaerobic dechlorination of PCBs.

  Environmental science & technology 20010215

• Dissemination of catabolic plasmids among desiccation-tolerant bacteria in soil microcosms.

  Applied biochemistry and biotechnology 20010101

• A meta cleavage pathway for 4-chlorobenzoate, an intermediate in the metabolism of 4-chlorobiphenyl by Pseudomonas cepacia P166.

  Applied and environmental microbiology 19950201

• Enhanced biodegradation of polychlorinated biphenyls after site-directed mutagenesis of a biphenyl dioxygenase gene.

  Applied and environmental microbiology 19931101