20535-83-5 | 6-Methoxy-7h-purin-2-amine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$15.00	$10.00
1g	95%	in stock	$17.00	$12.00
5g	95%	in stock	$27.00	$19.00
10g	95%	in stock	$33.00	$23.00
100g	95%	in stock	$211.00	$148.00
500g	95%	in stock	$957.00	$670.00

Description

• Catalog Number: AB06119
• Chemical Name: 6-Methoxy-7h-purin-2-amine
• CAS Number: 20535-83-5
• Molecular Formula: C6H7N5O
• Molecular Weight: 165.1527
• MDL Number: MFCD00133009
• SMILES: COc1nc(N)nc2c1nc[nH]2
• NSC Number: 37364

Computed Properties

• Complexity: 166
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -0.2

Literature

• Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O(6)-Methylguanine in Human Cells.

  Chemical research in toxicology 20180521

• Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.

  Archives of toxicology 20171001

• Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice.

  Chemical research in toxicology 20161121

• O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.

  Integrative biology : quantitative biosciences from nano to macro 20121001

• An approach based on ultra-high pressure liquid chromatography-tandem mass spectrometry to quantify O6-methyl and O6-carboxymethylguanine DNA adducts in intestinal cell lines.

  Journal of chromatography. A 20120928

• Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

  Molecular cell 20120713

• Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.

  Mutagenesis 20120701

• Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

  Bioorganic & medicinal chemistry 20120615

• A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.

  European journal of human genetics : EJHG 20120601

• Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine.

  DNA repair 20120601

• Management of glioblastoma in the elderly.

  Clinical advances in hematology & oncology : H&O 20120601

• Malignant progression in O6-methylguanine-DNA methyltransferase-deficient esophageal cancer cells is associated with Ezrin protein.

  DNA and cell biology 20120501

• DNA glycosylases: in DNA repair and beyond.

  Chromosoma 20120201

• Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas.

  NeuroImage 20120116

• Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats.

  Carcinogenesis 20120101

• Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.

  Analytical and bioanalytical chemistry 20120101

• Temozolomide: mechanisms of action, repair and resistance.

  Current molecular pharmacology 20120101

• Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method.

  BMC cancer 20120101

• MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR.

  Journal of translational medicine 20120101

• MutS homologue hMSH5: role in cisplatin-induced DNA damage response.

  Molecular cancer 20120101

• Detection of 1p19q deletion by real-time comparative quantitative PCR.

  Biomarker insights 20120101

• Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.

  International journal of molecular sciences 20120101

• Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death.

  PloS one 20120101

• Methylation-mediated molecular dysregulation in clinical oral malignancy.

  Journal of oncology 20120101

• Strategies to improve the killing of tumors using temozolomide: targeting the DNA repair protein MGMT.

  Current medicinal chemistry 20120101

• Inhibition of ENNG-induced pyloric stomach and small intestinal carcinogenesis in mice by high temperature- and pressure-treated garlic.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.

  PloS one 20120101

• Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

  Cancer prevention research (Philadelphia, Pa.) 20111101

• Aberrant DNA methylation and prostate cancer.

  Current genomics 20111101

• Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

  International journal of environmental research and public health 20111001

• Exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of O(6)-methylguanine.

  Journal of molecular biology 20110923

• Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours.

  British journal of cancer 20110906

• Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.

  Physical biology 20110801

• Role of DNA methylation in head and neck cancer.

  Clinical epigenetics 20110801

• Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.

  Carcinogenesis 20110701

• Synergistic cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine and absence of poly(ADP-ribose) glycohydrolase involves chromatin decondensation.

  International journal of oncology 20110701

• Quantitative analysis of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.

  Journal of neuro-oncology 20110601

• O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.

  Brain tumor pathology 20110401

• Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

  Cell death & disease 20110401

• Role of alkyltransferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus.

  Mutagenesis 20110301

• MGMT is a molecular determinant for potency of the DNA-EGFR-combi-molecule ZRS1.

  Molecular cancer research : MCR 20110301

• O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications.

  Journal of neuro-oncology 20110201

• MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

  Journal of neuro-oncology 20110201

• Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas.

  The American journal of surgical pathology 20110201

• [Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110201

• Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110115

• Development and validation of a new, sensitive immunochemical assay for O⁶-methylguanine in DNA and its application in a population study.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101

• Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.

  PloS one 20110101

• Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.

  Journal of biomedicine & biotechnology 20110101

• O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.

  BMC cancer 20110101

• Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis.

  International journal of environmental research and public health 20110101

• NNK-Induced Lung Tumors: A Review of Animal Model.

  Journal of oncology 20110101

• Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy.

  Journal of translational medicine 20110101

• Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.

  Infectious diseases in obstetrics and gynecology 20110101

• The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.

  Molecular cancer 20110101

• Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates.

  PloS one 20110101

• Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.

  PloS one 20110101

• Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells.

  PloS one 20110101

• Submicroscopic interstitial deletion of chromosome 11q22.3 in a girl with mild mental retardation and facial dysmorphism: Case report.

  Molecular cytogenetics 20110101

• Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.

  Molecular cancer 20110101

• Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.

  PloS one 20110101

• Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

  PloS one 20110101

• The role of tobacco-derived carcinogens in pancreas cancer.

  ISRN oncology 20110101

• Innovative Therapies against Human Glioblastoma Multiforme.

  ISRN oncology 20110101

• Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity.

  PloS one 20110101

• Direct detection and sequencing of damaged DNA bases.

  Genome integrity 20110101

• The prognostic impact of O6-methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: a clinicopathologic and immunohistochemical study of seven cases at a single institution.

  Indian journal of pathology & microbiology 20110101

• [Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro].

  TSitologiia i genetika 20110101

• Prevention of human papillomavirus-related malignancies of the female genital tract.

  Infectious diseases in obstetrics and gynecology 20110101

• A rapid, simple DNA mismatch repair substrate construction method.

  Frontiers in oncology 20110101

• Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.

  The Journal of biological chemistry 20101224

• Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.

  The Journal of biological chemistry 20101224

• Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  Carcinogenesis 20101201

• O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment.

  Neurosurgery 20101201

• Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.

  Biochemical pharmacology 20101101

• Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

  Molecular pharmacology 20101101

• Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.

  Gut 20101101

• Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.

  British journal of cancer 20101026

• Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.

  Human mutation 20101001

• Clinical significance of molecular biomarkers in glioblastoma.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20100901

• Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide.

  British journal of cancer 20100629

• Epigenetic aberrations and therapeutic implications in gliomas.

  Cancer science 20100601

• Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20100601

• [The expression of O6-methylguanine DNA methyltransferase and p53 in non-small cell lung cancer and the association with the prognosis].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100601

• CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection.

  Gastroenterology 20100501

• Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.

  The Journal of biological chemistry 20100430

• RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.

  DNA repair 20100404

• Recent advances in combined modality therapy.

  The oncologist 20100401

• O(6)-methylguanine in DNA: bad penny?

  Cell cycle (Georgetown, Tex.) 20100201

• Interaction of murine dnmt3a with DNA containing o6-methylguanine.

  Biochemistry. Biokhimiia 20100201

• Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).

  Cancer biology & therapy 20100101

• Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles.

  Cell cycle (Georgetown, Tex.) 20100101

• Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20100101

• MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.

  PloS one 20100101

• O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.

  Neuro-oncology 20100101

• Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference.

  BMC cancer 20100101

• Activated CD4+ T cells enhance radiation effect through the cooperation of interferon-gamma and TNF-alpha.

  BMC cancer 20100101

• Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

  BMC cancer 20100101

• Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.

  Breast cancer research : BCR 20100101

• Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.

  BMC cancer 20100101

• Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

  PloS one 20100101

• DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences.

  Journal of nucleic acids 20100101

• Temozolomide in malignant glioma.

  OncoTargets and therapy 20100101

• Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η.

  Journal of nucleic acids 20100101

• Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.

  Journal of nucleic acids 20100101

• Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.

  Molecular cancer 20100101

• Combining modularity, conservation, and interactions of proteins significantly increases precision and coverage of protein function prediction.

  BMC genomics 20100101

• Role of bevacizumab therapy in the management of glioblastoma.

  Cancer management and research 20100101

• Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.

  Asian Pacific journal of cancer prevention : APJCP 20100101

• Different threshold levels for 2-amino-3,8 dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4 (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.

  Molecular medicine reports 20100101

• O6-methylguanine repair by O6-alkylguanine-DNA alkyltransferase.

  The journal of physical chemistry. B 20091224

• Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?

  Leukemia & lymphoma 20091201

• A quantum chemical study of repair of O6-methylguanine to guanine by tyrosine: evaluation of the winged helix-turn-helix model.

  Journal of molecular modeling 20091101

• Gas-phase thermochemical properties of the damaged base O(6)-methylguanine versus adenine and guanine.

  The Journal of organic chemistry 20091002

• The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

  Molecular pharmacology 20091001

• Repair of O6-methylguanine to guanine by cysteine in the absence and presence of histidine and by cysteine thiolate anion: a quantum chemical study.

  Physical chemistry chemical physics : PCCP 20091001

• Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.

  Radiation research 20091001

• Epigenetic cross-talk between DNA methylation and histone modifications in human cancers.

  Yonsei medical journal 20090831

• Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.

  The Journal of biological chemistry 20090821

• Correlation of chromosomes 1p and 19q status and expressions of O6-methylguanine DNA methyltransferase (MGMT), p53 and Ki-67 in diffuse gliomas of World Health Organization (WHO) grades II and III: a clinicopathological study.

  Neuropathology and applied neurobiology 20090801

• Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy.

  British journal of cancer 20090707

• MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.

  Annals of oncology : official journal of the European Society for Medical Oncology 20090701

• Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression.

  Oncology reports 20090701

• Flipping of alkylated DNA damage bridges base and nucleotide excision repair.

  Nature 20090611

• Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.

  Cancer science 20090601

• Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090301

• A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.

  Oncogene 20090226

• Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells.

  Biochemical and biophysical research communications 20090206

• The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.

  Neuro-oncology 20090201

• Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20090201

• Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.

  DNA repair 20090101

• Epidemiology of brain tumors.

  Methods in molecular biology (Clifton, N.J.) 20090101

• O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

• Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.

  PloS one 20090101

• Molecular neuropathology of gliomas.

  International journal of molecular sciences 20090101

• Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation.

  BMC cancer 20090101

• Temozolomide and cisplatin in relapsed/refractory acute leukemia.

  Journal of hematology & oncology 20090101

• Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains.

  BMC microbiology 20090101

• Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum.

  Asian Pacific journal of cancer prevention : APJCP 20090101

• Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

  Cancer research 20081201

• IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression.

  Molecular cancer therapeutics 20081201

• Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.

  Mutagenesis 20080901

• Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.

  PLoS genetics 20080901

• Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes.

  Clinical interventions in aging 20080901

• An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.

  Journal of biochemistry 20080801

• Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.

  Molecular pharmacology 20080801

• Different initial steps of apoptosis induced by two types of antineoplastic drugs.

  Biochemical pharmacology 20080801

• Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells.

  Carcinogenesis 20080601

• A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.

  Analytical biochemistry 20080601

• Inhibition of the 5' to 3' exonuclease activity of hEXO1 by 8-oxoguanine.

  Environmental and molecular mutagenesis 20080601

• Effect of O6-methylguanine on the stability of G-quadruplex DNA.

  Journal of the American Chemical Society 20080528

• Mechanisms of chemoresistance to alkylating agents in malignant glioma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080515

• Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

• [Methylnitrosourea as challenge mutagen in assessment of the DNA mismatch repair (MMR) activity: association with some types of cancer].

  Genetika 20080501

• Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.

  Mutation research 20080402

• Ras regulation of DNA-methylation and cancer.

  Experimental cell research 20080401

• Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions.

  Histopathology 20080401

• Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction.

  Mutation research 20080227

• Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri.

  Neurology 20080219

• Mismatch repair proteins collaborate with methyltransferases in the repair of O(6)-methylguanine.

  DNA repair 20080201

• Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers.

  Journal of neuropathology and experimental neurology 20080101

• K-ras mutations in sinonasal cancers in relation to wood dust exposure.

  BMC cancer 20080101

• Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

  PloS one 20080101

• B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.

  PloS one 20080101

• Promoter methylation inhibits BRD7 expression in human nasopharyngeal carcinoma cells.

  BMC cancer 20080101

• Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

  BMC genomics 20080101

• High-fidelity correction of genomic uracil by human mismatch repair activities.

  BMC molecular biology 20080101

• Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases.

  Genome biology 20080101

• Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway.

  Journal of experimental & clinical cancer research : CR 20080101

• Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine.

  DNA repair 20071201

• Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells.

  International journal of cancer 20071115

• From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

  Cellular and molecular life sciences : CMLS 20071001

• Nelarabine: a novel purine antimetabolite antineoplastic agent.

  Clinical therapeutics 20070901

• Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

  Cancer research 20070815

• Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.

  Cell death and differentiation 20070801

• MGMT: a personal perspective.

  DNA repair 20070801

• Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma.

  Annals of hematology 20070801

• Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.

  Cancer research 20070715

• The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

  Bioorganic & medicinal chemistry 20070515

• Methylation of O6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

• Silencing of O6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa.

  Oncology reports 20070401

• Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.

  American journal of clinical pathology 20070301

• Dose response relationship in anti-stress gene regulatory networks.

  PLoS computational biology 20070301

• Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by 'wobble' pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.

  The Journal of biological chemistry 20070112

• Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

  Oncogene 20070111

• A distinct epigenetic signature at targets of a leukemia protein.

  BMC genomics 20070101

• Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.

  PloS one 20070101

• Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.

  PloS one 20070101

• The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.

  Nucleosides, nucleotides & nucleic acids 20070101

• Prostate cancer epigenetics: a review on gene regulation.

  Gene regulation and systems biology 20070101

• Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk.

  Carcinogenesis 20061101

• Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061010

• DNA stability in the gas versus solution phases: a systematic study of thirty-one duplexes with varying length, sequence, and charge level.

  Journal of the American Society for Mass Spectrometry 20061001

• A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.

  Cancer gene therapy 20060901

• DNA damage-induced cell death by apoptosis.

  Trends in molecular medicine 20060901

• Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.

  The Journal of biological chemistry 20060811

• Role of temozolomide in pediatric brain tumors.

  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20060701

• Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk.

  Pharmacogenetics and genomics 20060701

• DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.

  Clinical lung cancer 20060701

• High frequency and strong prognostic relevance of O6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the Middle East.

  Human pathology 20060601

• ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.

  Molecular cell 20060519

• The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.

  Organic & biomolecular chemistry 20060507

• In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.

  Cancer 20060415

• Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

• DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors.

  The Journal of pharmacology and experimental therapeutics 20060201

• O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

  Journal of neurochemistry 20060201

• Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.

  The Journal of molecular diagnostics : JMD 20060201

• Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity.

  The journal of medical investigation : JMI 20060201

• Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.

  Journal of the National Cancer Institute 20060104

• [Comparison of geno- and cytotoxicity of methylnitrosourea on MMR-proficient and MMR-deficient human tumor cell lines].

  Tsitologiia 20060101

• Promoter hypermethylation of DNA repair gene MGMT in laryngeal squamous cell carcinoma.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

  Molecular cancer 20060101

• Predictive utility of circulating methylated DNA in serum of melanoma patients receiving biochemotherapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220

• Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis.

  Cancer letters 20050908

• Epigenetic silencing of the MGMT gene in cancer.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20050801

• Nelarabine: a nucleoside analog with efficacy in T-cell and other leukemias.

  The Annals of pharmacotherapy 20050601

• Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis.

  Biochemistry 20050510

• [Effect of beta-carotene supplementation on DNA oxidative and alkylation damage in rats].

  Wei sheng yan jiu = Journal of hygiene research 20050501

• Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.

  Cancer research 20050415

• Genetic pathways to glioblastomas.

  Neuropathology : official journal of the Japanese Society of Neuropathology 20050301

• Lack of EGF receptor contributes to drug sensitivity of human germline cells.

  British journal of cancer 20050131

• Inhibition by allyl sulfides and crushed garlic of O6-methylguanine formation in liver DNA of dimethylnitrosamine-treated rats.

  Nutrition and cancer 20050101

• Electrochemical detection of lesions in DNA.

  Bioconjugate chemistry 20050101

• PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells.

  Nucleic acids research 20050101

• Epigenetics of cervical cancer. An overview and therapeutic perspectives.

  Molecular cancer 20050101

• Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexity.

  Mutation research 20041221

• The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.

  The Journal of pharmacology and experimental therapeutics 20041201

• Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041201

• Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.

  Oncogene 20040805

• Proofreading activity of Pfu thermostable DNA polymerase on a 6-O-methylguanine-containing template monitored by ESI-FTICR mass spectrometry.

  Chembiochem : a European journal of chemical biology 20040705

• DNA damage and repair measured in different genomic regions using the comet assay with fluorescent in situ hybridization.

  Mutagenesis 20040701

• Synthesis and characterization of bifunctional probes for the specific labeling of fusion proteins.

  Bioorganic & medicinal chemistry letters 20040607

• The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.

  DNA repair 20040603

• Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.

  Current opinion in investigational drugs (London, England : 2000) 20040601

• Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients.

  Oncogene 20040513

• Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations.

  DNA repair 20040401

• Detection of O6-carboxymethyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA using a quantitative immunoslot blot assay.

  Chemical research in toxicology 20040301

• The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.

  Chemical research in toxicology 20040301

• [Promoter hypermethylation of DNA repair gene O6-methylguanine DNA methyltransferase in laryngeal squamous cell carcinoma].

  Zhonghua er bi yan hou ke za zhi 20040301

• Guanine 6-O-methylation pattern within the dioxin responsive element of the CYP1A1 enhancer shows two critical guanines for AhR/ARNT binding.

  Chemistry & biodiversity 20040301

• Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

  Journal of medicinal chemistry 20040129

• Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

  Biochemistry 20040120

• Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

  Oncogene 20040115

• Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

  Oncogene 20040108

• Promoter methylation status of multiple genes in brain metastases of solid tumors.

  International journal of molecular medicine 20040101

• O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.

  Bioconjugate chemistry 20040101

• Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

  Cytogenetic and genome research 20040101

• DNA damage processing and aberration formation in plants.

  Cytogenetic and genome research 20040101

• Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities.

  Molecular cancer 20040101

• BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20040101

• The syntheses of tricyclic analogues of O6-methylguanine.

  Organic & biomolecular chemistry 20031207

• The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the 'bypass' DNA polymerase eta and the replicative DNA polymerase alpha.

  Chemical research in toxicology 20031201

• O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics.

  Chemical research in toxicology 20031101

• Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.

  The Biochemical journal 20031015

• The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.

  Cancer research 20030915

• Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family.

  Emerging infectious diseases 20030701

• In vivo protection of hematopoietic cells from alkylator-mediated DNA damage.

  Current hematology reports 20030701

• Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

  Chemical research in toxicology 20030601

• K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.

  Chemical research in toxicology 20030401

• DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system.

  Journal of chemotherapy (Florence, Italy) 20030401

• Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma.

  International journal of molecular medicine 20030101

• Evaluation of O6-methylguanine DNA methyltransferase activity in patients with gastric cancer.

  Oncology research 20030101

• Genotoxic methylating agents modulate extracellular signal regulated kinase activity through MEK-dependent, glutathione-, and DNA methylation-independent mechanisms in lung epithelial cells.

  Chemical research in toxicology 20030101

• Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis.

  Asian Pacific journal of cancer prevention : APJCP 20030101

• Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase.

  The International journal of biological markers 20030101

• Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.

  Nutrition and cancer 20030101

• Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine.

  Mutagenesis 20021101

• O6-benzylguanine-mediated enhancement of chemotherapy.

  Molecular cancer therapeutics 20020901

• Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.

  Journal of medicinal chemistry 20020801

• DNA repair in resistance to alkylating anticancer drugs.

  International journal of clinical pharmacology and therapeutics 20020801

• Pharmacological strategies to increase the antitumor activity of methylating agents.

  Current medicinal chemistry 20020701

• DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.

  Mutation research 20020320

• Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.

  The journal of medical investigation : JMI 20020201

• Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.

  Biochemistry 20020122

• Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.

  Biochemistry 20020122

• Monitoring for DNA damage of humans occupationally exposed to methyl bromide.

  Anticancer research 20020101

• Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity.

  Journal of experimental therapeutics & oncology 20020101

• Glutathione S-transferase and O6-methylguanine DNA methyl transferase activities in patients with thyroid papillary carcinoma.

  Cancer investigation 20020101

• Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.

  Cancer research 20011201

• Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers.

  Annals of surgical oncology 20011201

• The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.

  Chemico-biological interactions 20011128

• Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.

  Mutation research 20011101

• Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.

  Mutation research 20010822

• Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

  Cancer research 20010815

• Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA.

  Mutation research 20010808

• High-performance liquid chromatographic method with electrochemical detection for the analysis of O6-methylguanine.

  Journal of chromatography. B, Biomedical sciences and applications 20010805

• Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

  Cancer research 20010801

• Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA.

  The Journal of pharmacology and experimental therapeutics 20010701

• Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.

  Chemical research in toxicology 20010701

• The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.

  The Journal of biological chemistry 20010629

• Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.

  Mutation research 20010602

• [Repair of alkylated DNA and consequences of its failure].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010601

• Micellar electrokinetic capillary chromatography quantification of cytosine arabinoside and its metabolite, uracil arabinoside, in human serum.

  Journal of chromatography. B, Biomedical sciences and applications 20010415

• Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro.

  Mutation research 20010404

• Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

  Cancer chemotherapy and pharmacology 20010401

• Health span and life span in transgenic mice with modulated DNA repair.

  Annals of the New York Academy of Sciences 20010401

• Role of cytochrome P450 in DNA damage produced by treatment of colon cells with 1,2-dimethylhydrazine.

  International journal of oncology 20010301

• Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries.

  Carcinogenesis 20010301

• p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

  Cancer research 20010301

• Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon.

  The journal of medical investigation : JMI 20010201

• Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

  Cancer research 20010101

• DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.

  Progress in nucleic acid research and molecular biology 20010101

• BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.

  Progress in nucleic acid research and molecular biology 20010101

• O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.

  Nutrition and cancer 20010101

• Novel DNA repair alkyltransferase from Caenorhabditis elegans.

  Environmental and molecular mutagenesis 20010101

• DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.

  Mutation research 20000401

• Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.

  Mutation research 20000214

• Chromium(III) decreases the fidelity of human DNA polymerase beta.

  Biochemistry 19980630