206184-49-8 | Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1)

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$8.00	$5.00
5mg	95%	in stock	$10.00	$7.00
10mg	95%	in stock	$13.00	$9.00
5g	95%	in stock	$25.00	$18.00

Description

• Catalog Number: AB06793
• Chemical Name: Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1)
• CAS Number: 206184-49-8
• Molecular Formula: C9H16N5O5P
• Molecular Weight: 305.2276
• MDL Number: MFCD11519982
• SMILES: C[C@H](Cn1cnc2c1ncnc2N)OCP(=O)(O)O.O

Computed Properties

• Complexity: 354
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 5

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• Tenofovir use and renal insufficiency among pregnant and general adult population of HIV-infected, ART-naïve individuals in Lilongwe, Malawi.

  PloS one 20120101

• Renal toxicity associated with antiretroviral therapy.

  HIV clinical trials 20120101

• Efficacy of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naïve HIV-1-infected patients: week-192 overall and subgroup analyses from STARTMRK.

  HIV clinical trials 20120101

• Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.

  Antiviral therapy 20120101

• Cost-effectiveness of tenofovir instead of zidovudine for use in first-line antiretroviral therapy in settings without virological monitoring.

  PloS one 20120101

• Drug-induced acute interstitial nephritis mimicking acute tubular necrosis after initiation of tenofovir-containing antiretroviral therapy in patient with HIV-1 infection.

  Internal medicine (Tokyo, Japan) 20120101

• The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicity.

  PloS one 20120101

• First reported case of tenofovir-induced photoallergic reaction.

  Indian journal of pharmacology 20120101

• Antiretroviral prophylaxis: a defining moment in HIV control.

  Lancet (London, England) 20111217

• Comparative outcomes of tenofovir-based and zidovudine-based antiretroviral therapy regimens in Lusaka, Zambia.

  Journal of acquired immune deficiency syndromes (1999) 20111215

• Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.

  The Journal of infectious diseases 20111215

• Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission.

  Science translational medicine 20111207

• Drugs in traffic: the road to approval.

  Nature medicine 20111206

• Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescents.

  British journal of clinical pharmacology 20111201

• Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.

  Journal of hepatology 20111201

• Promising prevention approaches: tenofovir gel and prophylactic use of antiretroviral medications.

  Current HIV/AIDS reports 20111201

• Cost effectiveness of tenofovir disoproxil fumarate for the treatment of chronic hepatitis B from a Canadian public payer perspective.

  PharmacoEconomics 20111201

• Emerging pipeline drugs for hepatitis B infection.

  Expert opinion on emerging drugs 20111201

• HIV preexposure prophylaxis: new data and potential use.

  Topics in antiviral medicine 20111201

• Microbicides for HIV prevention.

  The Indian journal of medical research 20111201

• Sustained virological response to a raltegravir-containing salvage therapy in an HIV-2-infected patient.

  AIDS (London, England) 20111128

• The price of tenofovir-emtricitabine undermines the cost-effectiveness and advancement of pre-exposure prophylaxis.

  AIDS (London, England) 20111128

• Pharmacokinetics and placental transfer of single-dose tenofovir 1% vaginal gel in term pregnancy.

  The Journal of infectious diseases 20111115

• Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect tubular rather than glomerular toxicity.

  AIDS (London, England) 20111113

• Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains.

  Journal of viral hepatitis 20111101

• Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate and emtricitabine.

  AIDS care 20111101

• pH-responsive nanoparticles releasing tenofovir intended for the prevention of HIV transmission.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20111101

• Cost and cost-effectiveness of switching from d4T or AZT to a TDF-based first-line regimen in a resource-limited setting in rural Lesotho.

  Journal of acquired immune deficiency syndromes (1999) 20111101

• Randomized comparison of metabolic and renal effects of saquinavir/r or atazanavir/r plus tenofovir/emtricitabine in treatment-naïve HIV-1-infected patients.

  HIV medicine 20111101

• HIV-HBV vaccine escape mutant infection with loss of HBV surface antibody and persistent HBV viremia on tenofovir/emtricitabine without antiviral resistance.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20111101

• Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patients.

  Journal of acquired immune deficiency syndromes (1999) 20111101

• Application of kinase bypass strategies to nucleoside antivirals.

  Antiviral research 20111101

• Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants.

  Antiviral research 20111101

• FDA notifications. Complera approved.

  AIDS alert 20111101

• A quality by design (QbD) case study on liposomes containing hydrophilic API: I. Formulation, processing design and risk assessment.

  International journal of pharmaceutics 20111031

• Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.

  Cell host & microbe 20111020

• Optimizing initial therapy for HIV infection.

  The Journal of infectious diseases 20111015

• Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results.

  The Journal of infectious diseases 20111015

• Scientific report: highlights of 24th ICAR, 8-11 May 2011, Sofia, Bulgaria.

  Antiviral chemistry & chemotherapy 20111007

• Hyperlipidemic acute pancreatitis: a possible role of antiretroviral therapy with entecavir.

  Minerva anestesiologica 20111001

• Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature.

  Scandinavian journal of infectious diseases 20111001

• Successful tenofovir treatment for fulminant hepatitis B infection in an infant.

  The Pediatric infectious disease journal 20111001

• Epidemiological impact of tenofovir gel on the HIV epidemic in South Africa.

  Journal of acquired immune deficiency syndromes (1999) 20111001

• Membranous nephropathy in an HIV-positive patient complicated with hepatitis B virus infection.

  Clinical and experimental nephrology 20111001

• Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus emtricitabine in patients with chronic hepatitis B: a European multicenter study.

  Antiviral research 20111001

• Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in HIV-1-infected patients with virological suppression under antiretroviral therapy.

  The Journal of antimicrobial chemotherapy 20111001

• Impact of tenofovir versus abacavir on HIV-related endothelial dysfunction.

  AIDS patient care and STDs 20111001

• Modeling interventions to assess HIV epidemic impact in Africa.

  Journal of acquired immune deficiency syndromes (1999) 20111001

• Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir.

  Alimentary pharmacology & therapeutics 20111001

• Iatrogenic Cushing syndrome after a single intramuscular corticosteroid injection and concomitant protease inhibitor therapy.

  Journal of the American Academy of Dermatology 20111001

• Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20111001

• Contraceptive choices, pregnancy rates, and outcomes in a microbicide trial.

  Obstetrics and gynecology 20111001

• Canadian patients with chronic hepatitis B cannot access appropriate drug treatments: a call for change.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20111001

• Association of osteonecrosis and osteoporosis in HIV-1-infected patients.

  AIDS (London, England) 20110924

• Phase 2 study of cobicistat versus ritonavir each with once-daily atazanavir and fixed-dose emtricitabine/tenofovir df in the initial treatment of HIV infection.

  AIDS (London, England) 20110924

• Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110918

• Product and process understanding of a novel pediatric anti-HIV tenofovir niosomes with a high-pressure homogenizer.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110918

• [Human immunodeficiency virus and Chagas disease coinfection treated successfully with benznidazole and a raltegravir-based antiretroviral regimen: a case report].

  Medicina clinica 20110910

• Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC-MS/MS detection.

  Journal of pharmaceutical and biomedical analysis 20110910

• Tenofovir for treatment of hepatitis B virus reactivation in patients with chronic GVHD.

  Bone marrow transplantation 20110901

• HIV prevention in southern Africa: why we must reassess our strategies?

  Tropical medicine & international health : TM & IH 20110901

• Comparison of abacavir/lamivudine and tenofovir/emtricitabine among treatment-naive HIV-infected patients initiating therapy.

  Journal of acquired immune deficiency syndromes (1999) 20110901

• IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.

  Blood 20110901

• Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients.

  AIDS patient care and STDs 20110901

• Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.

  Virology 20110901

• Microbicide might protect pregnant women from HIV. Susceptibility is high for them.

  AIDS alert 20110901

• Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

  Journal of medicinal chemistry 20110825

• Synergy against drug-resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination.

  AIDS (London, England) 20110824

• Relationship between renal dysfunction, nephrotoxicity and death among HIV adults on tenofovir.

  AIDS (London, England) 20110824

• Antiretroviral therapy alone resulted in successful resolution of large idiopathic esophageal ulcers in a patient with acute retroviral syndrome.

  AIDS (London, England) 20110824

• The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations.

  Antiviral chemistry & chemotherapy 20110823

• Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.

  Nature 20110817

• Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral pre-exposure prophylaxis.

  Journal of acquired immune deficiency syndromes (1999) 20110815

• Proper antiviral therapy for hepatitis B virus-associated acute-on-chronic liver failure.

  Hepatology (Baltimore, Md.) 20110801

• Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention.

  Journal of pharmaceutical sciences 20110801

• Tenofovir-induced renal toxicity in 324 HIV-infected, antiretroviral-naïve patients.

  Scandinavian journal of infectious diseases 20110801

• Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells.

  Journal of acquired immune deficiency syndromes (1999) 20110801

• Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy.

  Kidney international 20110801

• One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.

  Journal of virology 20110801

• Successful switch to tenofovir after suboptimal response to entecavir in an immunocompromised patient with chronic hepatitis B and without genotypic hepatitis B virus resistance.

  Infection 20110801

• Serum HBsAg decline during long-term potent nucleos(t)ide analogue therapy for chronic hepatitis B and prediction of HBsAg loss.

  The Journal of infectious diseases 20110801

• Severe acute renal failure in an HIV-infected patient after only 2 weeks of tenofovir-based antiretroviral therapy.

  AIDS patient care and STDs 20110801

• Bilateral pathologic hip fractures associated with antiretroviral therapy: a case report.

  The Journal of bone and joint surgery. American volume 20110720

• Tenofovir and emtricitabine cerebrospinal fluid-to-plasma ratios correlate to the extent of blood-brainbarrier damage.

  AIDS (London, England) 20110717

• Rilpivirine: a step forward in tailored HIV treatment.

  Lancet (London, England) 20110716

• Antiretrovirals for HIV prevention: translating promise into praxis.

  Lancet (London, England) 20110716

• Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial.

  Lancet (London, England) 20110716

• Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial.

  Lancet (London, England) 20110716

• Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.

  Lancet (London, England) 20110716

• Battles with donors cloud Malawi's HIV prevention plan.

  Lancet (London, England) 20110716

• The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.

  Biochemical pharmacology 20110715

• Tenofovir works as pre-exposure prophylaxis against HIV, two studies confirm.

  BMJ (Clinical research ed.) 20110715

• Lipid profiles for nevirapine vs. atazanavir/ritonavir, both combined with tenofovir disoproxil fumarate and emtricitabine over 48 weeks, in treatment-naïve HIV-1-infected patients (the ARTEN study).

  HIV medicine 20110701

• Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.

  The Journal of infectious diseases 20110701

• Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110701

• Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons.

  AIDS (London, England) 20110619

• Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG A5202.

  The Journal of infectious diseases 20110615

• Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.

  Journal of viral hepatitis 20110601

• Prevention of lamivudine-resistant hepatitis B recurrence after liver transplantation with entecavir plus tenofovir combination therapy and perioperative hepatitis B immunoglobulin only.

  Transplant infectious disease : an official journal of the Transplantation Society 20110601

• Circulating Tregs correlate with viral load reduction in chronic HBV-treated patients with tenofovir disoproxil fumarate.

  Journal of clinical immunology 20110601

• Microbial biofilms on the surface of intravaginal rings worn in non-human primates.

  Journal of medical microbiology 20110601

• Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transporters.

  Laboratory investigation; a journal of technical methods and pathology 20110601

• Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.

  Scandinavian journal of gastroenterology 20110601

• Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz.

  AIDS care 20110601

• Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

  Antiviral research 20110601

• Early end for FEM-PrEP HIV prevention trial.

  AIDS patient care and STDs 20110601

• Endocrine complications of human immunodeficiency virus infection: hypogonadism, bone disease and tenofovir-related toxicity.

  Best practice & research. Clinical endocrinology & metabolism 20110601

• Determination of kidney function before tenofovir initiation: four-fold difference in need of tenofovir dose reduction depending on method used.

  Journal of acquired immune deficiency syndromes (1999) 20110601

• A comparison of tenofovir-associated renal function changes in HIV-infected African Americans vs Caucasians.

  Journal of the National Medical Association 20110601

• [Interferon-based versus direct antiviral therapy in patients with chronic hepatitis B].

  Orvosi hetilap 20110529

• Study halted: no benefit seen from antiretroviral pill in preventing HIV in women.

  JAMA 20110518

• Managing hepatitis B/HIV co-infected: adding entecavir to truvada (tenofovir disoproxil/emtricitabine) experienced patients.

  AIDS (London, England) 20110515

• [Efavirenz in fixed combination with tenofovir and emtricitabine. Long-term effectiveness verified in new studies].

  MMW Fortschritte der Medizin 20110505

• Normal plasma FGF23 levels kinetic in tenofovir-related hypophosphatemic osteomalacia in an HIV-infected patient with von Recklinghausen disease.

  Joint, bone, spine : revue du rhumatisme 20110501

• From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir.

  Expert opinion on drug safety 20110501

• Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trial.

  Contemporary clinical trials 20110501

• Metabolic benefits of switching to tenofovir/lamivudine after long-term use of stavudine/lamivudine in NNRTI-based antiretroviral regimens: a prospective study.

  The Journal of infection 20110501

• Low incidence of renal impairment observed in tenofovir-treated patients.

  The Journal of antimicrobial chemotherapy 20110501

• Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20110501

• Improvement in chronic renal impairment following the discontinuation of tenofovir in two HIV-infected patients.

  Nephrology (Carlton, Vic.) 20110501

• Novel nephrotoxins.

  Advances in chronic kidney disease 20110501

• Renal impairment in HIV-1 infected patients receiving antiretroviral regimens including tenofovir in a resource-limited setting.

  The Southeast Asian journal of tropical medicine and public health 20110501

• [New drugs of treatment of patients with chronic hepatitis B].

  Nihon rinsho. Japanese journal of clinical medicine 20110501

• Tenofovir therapy in hepatitis B virus-positive solid-organ transplant recipients.

  Transplantation 20110427

• Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.

  AIDS (London, England) 20110424

• Atazanavir pharmacokinetics with and without tenofovir during pregnancy.

  Journal of acquired immune deficiency syndromes (1999) 20110415

• Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques.

  Virology 20110410

• Preexposure chemoprophylaxis for HIV prevention.

  The New England journal of medicine 20110407

• Preexposure chemoprophylaxis for HIV prevention.

  The New England journal of medicine 20110407

• Preexposure chemoprophylaxis for HIV prevention.

  The New England journal of medicine 20110407

• Preexposure chemoprophylaxis for HIV prevention.

  The New England journal of medicine 20110407

• Preexposure chemoprophylaxis for HIV prevention.

  The New England journal of medicine 20110407

• Treatment of chronic hepatitis B: update of the recommendations from the 2007 Italian Workshop.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20110401

• Tenofovir discontinuation could predispose to urolithiasis in atazanavir-treated patients.

  The Journal of infection 20110401

• [HIV infected women with intense bone and muscular pain and general weakness].

  Enfermedades infecciosas y microbiologia clinica 20110401

• Clinical experience with nevirapine combined with tenofovir plus emtricitabine or lamivudine-containing regimens in HIV-infected subjects.

  International journal of STD & AIDS 20110401

• Randomized, phase 2 evaluation of two single-tablet regimens elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for the initial treatment of HIV infection.

  AIDS (London, England) 20110327

• Concomitant administration of BILR 355/r with emtricitabine/tenofovir disoproxil fumarate increases exposure to emtricitabine and tenofovir: a randomized, open-label, prospective study.

  Basic & clinical pharmacology & toxicology 20110301

• The role of nucleoside and nucleotide analogues in nodular regenerative hyperplasia in HIV-infected patients: a case control study.

  Journal of hepatology 20110301

• Lipid-lowering effect of tenofovir in HIV-infected patients.

  The Journal of antimicrobial chemotherapy 20110301

• Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years.

  Journal of acquired immune deficiency syndromes (1999) 20110301

• Review article: chronic hepatitis B - anti-viral or immunomodulatory therapy?

  Alimentary pharmacology & therapeutics 20110301

• Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.

  Journal of renal care 20110301

• Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure.

  Hepatology (Baltimore, Md.) 20110301

• Is tenofovir-related renal toxicity incompletely reversible?

  Journal of acquired immune deficiency syndromes (1999) 20110301

• No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus.

  Hepatology (Baltimore, Md.) 20110301

• Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20110301

• [Two cases of Fanconi's syndrome induced by tenofovir in the Ivory Coast].

  Medecine et maladies infectieuses 20110201

• Tenofovir (TDF)-selected or abacavir (ABC)-selected low-frequency HIV type 1 subpopulations during failure with persistent viremia as detected by ultradeep pyrosequencing.

  AIDS research and human retroviruses 20110201

• Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B.

  Gut 20110201

• Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection.

  The Journal of antimicrobial chemotherapy 20110201

• Tenofovir salvage for nucleoside experienced patients: muddy waters?

  Gut 20110201

• Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings.

  AIDS patient care and STDs 20110201

• [Tenofovir, an antiviral agent with low spermiostatic activity].

  Actas urologicas espanolas 20110201

• [Efficacy and treatment strategy for drug resistances of nucleos(t)ide analogues for chronic hepatitis B].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110201

• Initial results reported on raltegravir once-daily dosing.

  AIDS patient care and STDs 20110201

• Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapy.

  AIDS (London, England) 20110128

• Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men.

  MMWR. Morbidity and mortality weekly report 20110128

• HIV prevention in women: next steps.

  Science (New York, N.Y.) 20110121

• AIDS: Drugs that prevent HIV infection.

  Nature 20110120

• [HIV and AIDS: what's new in 2010?].

  Revue medicale suisse 20110119

• Prospective study of renal function in HIV-infected pediatric patients receiving tenofovir-containing HAART regimens.

  AIDS (London, England) 20110114

• No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults.

  AIDS (London, England) 20110114

• Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B.

  Journal of hepatology 20110101

• Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B.

  Gastroenterology 20110101

• Implications of HIV PrEP trials results.

  AIDS research and human retroviruses 20110101

• [Immune reconstitution inflammatory syndrome associated with eosinophilic pustular folliculitis in an HIV-infected patient].

  Medecine et maladies infectieuses 20110101

• Chronic hepatitis B: peginterferon or nucleos(t)ide analogues?

  Liver international : official journal of the International Association for the Study of the Liver 20110101

• Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues.

  Liver international : official journal of the International Association for the Study of the Liver 20110101

• Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues.

  Liver international : official journal of the International Association for the Study of the Liver 20110101

• Hepatitis B virus resistance to antiviral drugs: where are we going?

  Liver international : official journal of the International Association for the Study of the Liver 20110101

• The impact of human immunodeficiency virus on viral hepatitis.

  Liver international : official journal of the International Association for the Study of the Liver 20110101

• Renal disease associated with antiretroviral therapy in the treatment of HIV.

  Nephron. Clinical practice 20110101

• The ART of preventing HIV.

  Nature medicine 20110101

• K70Q adds high-level tenofovir resistance to 'Q151M complex' HIV reverse transcriptase through the enhanced discrimination mechanism.

  PloS one 20110101

• Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease.

  Hepatology (Baltimore, Md.) 20110101

• A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.

  PloS one 20110101

• Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naïve human immunodeficiency virus-infected patients in the United States.

  Journal of medical economics 20110101

• Early changes in inflammatory and pro-thrombotic biomarkers in patients initiating antiretroviral therapy with abacavir or tenofovir.

  BMC infectious diseases 20110101

• Analysis of drug resistance during HIV RNA viraemia in the MONET trial of darunavir/ritonavir monotherapy.

  Antiviral therapy 20110101

• Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.

  Antiviral therapy 20110101

• HIV-2 infection, end-stage renal disease and protease inhibitor intolerance: which salvage regimen?

  Clinical drug investigation 20110101

• Update on microbicide research and development - seeking new HIV prevention tools for women.

  European journal of medical research 20110101

• Bioequivalence study of two oral tablet formulations containing tenofovir disoproxil fumarate in healthy volunteers.

  Arzneimittel-Forschung 20110101

• Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial.

  Trials 20110101

• Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review.

  Virology journal 20110101

• Renal safety of a tenofovir-containing first line regimen: experience from an antiretroviral cohort in rural Lesotho.

  PloS one 20110101

• [Renal adverse reactions of antiretroviral medication: proximal tubular dysfunction associated with tenofovir].

  Nederlands tijdschrift voor geneeskunde 20110101

• Six-year follow-up of hepatitis B surface antigen concentrations in tenofovir disoproxil fumarate treated HIV-HBV-coinfected patients.

  Antiviral therapy 20110101

• Long-term renal safety of tenofovir disoproxil fumarate in vertically HIV-infected children, adolescents and young adults: a 60-month follow-up study.

  Clinical drug investigation 20110101

• [Current treatment of hepatitis B infection: where do the new nucleos(t)ide analogues fit in?].

  Gastroenterologia y hepatologia 20110101

• Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviral-naive HIV-1 patients: the ARTEN Trial.

  Antiviral therapy 20110101

• The role of HIV and antiretroviral therapy in bone disease.

  AIDS reviews 20110101

• Monitoring of Renal Function among HIV-Infected Patients Receiving Tenofovir in a Resource-Limited Setting.

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20110101

• Development and validation of an LC/MS/MS method for the determination of tenofovir in monkey plasma.

  Biological & pharmaceutical bulletin 20110101

• Tenofovir as a first line option for prophylaxis in a patient with hepatitis B virus associated nephrotic syndrome.

  Annals of hepatology 20110101

• Low-density lipoprotein size and lipoprotein-associated phospholipase A2 in HIV-infected patients switching to abacavir or tenofovir.

  Antiviral therapy 20110101

• Pharmacokinetics of switching unboosted atazanavir coadministered with tenofovir disoproxil fumarate from 400 mg once daily to 200 mg twice daily in HIV-positive patients.

  Antiviral therapy 20110101

• Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.

  BMC infectious diseases 20110101

• Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment.

  Methods in molecular biology (Clifton, N.J.) 20110101

• Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients.

  PloS one 20110101

• Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding.

  Antiviral therapy 20110101

• Cost-effectiveness of nucleoside reverse transcriptase inhibitor pairs in efavirenz-based regimens for treatment-naïve adults with HIV infection in the United States.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110101

• Bone mineral density in HIV-negative men participating in a tenofovir pre-exposure prophylaxis randomized clinical trial in San Francisco.

  PloS one 20110101

• Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil.

  BMC infectious diseases 20110101

• Enrollment characteristics and risk behaviors of injection drug users participating in the Bangkok Tenofovir Study, Thailand.

  PloS one 20110101

• Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy.

  BMC infectious diseases 20110101

• Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention.

  PloS one 20110101

• Efficacy, adherence and tolerability of once daily tenofovir DF-containing antiretroviral therapy in former injecting drug users with HIV-1 receiving opiate treatment: results of a 48-week open-label study.

  European journal of medical research 20110101

• Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa.

  Antiviral therapy 20110101

• Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens.

  Antiviral therapy 20110101

• A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel.

  PloS one 20110101

• Predictors of limb fat gain in HIV positive patients following a change to tenofovir-emtricitabine or abacavir-lamivudine.

  PloS one 20110101

• Tenofovir induced acute kidney injury in a patient with unilateral renal agenesis despite initially non-impaired renal function.

  European journal of medical research 20110101

• Temporal changes in renal glomerular function associated with the use of Tenofovir Disoproxil Fumarate in HIV-infected Nigerians.

  West African journal of medicine 20110101

• Oral tenofovir arm of VOICE trial discontinued early.

  IAVI report : newsletter on international AIDS vaccine research 20110101

• Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).

  Antiviral therapy 20110101

• In utero exposure to tenofovir disoproxil fumarate does not impair growth and bone health in HIV-uninfected children born to HIV-infected mothers.

  Antiviral therapy 20110101

• Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells.

  Antiviral therapy 20110101

• Examination of noninferiority, safety, and tolerability of lopinavir/ritonavir and raltegravir compared with lopinavir/ritonavir and tenofovir/ emtricitabine in antiretroviral-naïve subjects: the progress study, 48-week results.

  HIV clinical trials 20110101

• Hepatitis B virus related membranous glomerulonephritis and proteinuria treated with lamivudine and tenofovir.

  BMJ case reports 20110101

• Approach to chronic hepatitis B virus infection.

  JNMA; journal of the Nepal Medical Association 20110101

• Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.

  The New England journal of medicine 20101230

• Oral preexposure prophylaxis for HIV--another arrow in the quiver?

  The New England journal of medicine 20101230

• Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients.

  Journal of acquired immune deficiency syndromes (1999) 20101215

• Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: the EPIB 2008 study.

  Journal of hepatology 20101201

• Long-term therapy with tenofovir is effective for patients co-infected with human immunodeficiency virus and hepatitis B virus.

  Gastroenterology 20101201

• Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities.

  Kidney international 20101201

• Cost-utility analysis of tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201

• Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201

• The risk of HIV drug resistance following implementation of pre-exposure prophylaxis.

  Current opinion in infectious diseases 20101201

• A tailored dose of tenofovir could reduce its impact on bone mass in HIV Type 1-infected children and adolescents: a report from 5 years of clinical experience.

  AIDS research and human retroviruses 20101201

• Virologic and clinical outcomes in HIV/HBV coinfected patients on tenofovir-containing HAART.

  Gastroenterology 20101201

• Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy.

  Kidney international 20101201

• Avascular necrosis of the talus in a HIV-infected patient.

  Foot & ankle international 20101201

• [What's new in dermatological treatments?].

  Annales de dermatologie et de venereologie 20101201

• Microbicides & their implications in HIV prevention.

  The Indian journal of medical research 20101201

• HIV-2 goes global: an unaddressed issue in Indian anti-retroviral programmes.

  The Indian journal of medical research 20101201

• High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study.

  AIDS (London, England) 20101127

• A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people.

  AIDS (London, England) 20101127

• Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients.

  World journal of gastroenterology 20101121

• [Tenofovir associated hypokalaemia in a patient with normal renal function].

  Enfermedades infecciosas y microbiologia clinica 20101101

• [Fanconi syndrome associated with tenofovir treatment: a presentation of two cases].

  Enfermedades infecciosas y microbiologia clinica 20101101

• Lack of interaction between the HIV integrase inhibitor S/GSK1349572 and tenofovir in healthy subjects.

  Journal of acquired immune deficiency syndromes (1999) 20101101

• Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV.

  Journal of acquired immune deficiency syndromes (1999) 20101101

• Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.

  Journal of acquired immune deficiency syndromes (1999) 20101101

• Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.

  Protein science : a publication of the Protein Society 20101101

• Changes in the renal function after tenofovir-containing antiretroviral therapy initiation in a Senegalese cohort (ANRS 1215).

  AIDS research and human retroviruses 20101101

• Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients.

  Clinical pharmacology and therapeutics 20101101

• First real success for anti-HIV gel: a new start for HIV microbicides?

  Future microbiology 20101101

• Maternal and nenonatal tenofovir and emtricitabine to prevent vertical transmission of HIV-1: tolerance and resistance.

  AIDS (London, England) 20101023

• Preventing HIV infection: turning the tide for young women.

  Lancet (London, England) 20101016

• Fate of the antiretroviral drug tenofovir in agricultural soil.

  The Science of the total environment 20101015

• Low bone mineral density with tenofovir: does statistically significant mean clinically significant?

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101015

• Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101015

• Antiretroviral therapies in women after single-dose nevirapine exposure.

  The New England journal of medicine 20101014

• Tenofovir or zidovudine in three-drug combination therapy with one nucleoside reverse transcriptase inhibitor and one non-nucleoside reverse transcriptase inhibitor for initial treatment of HIV infection in antiretroviral-naïve individuals.

  The Cochrane database of systematic reviews 20101006

• Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection.

  Gastroenterology 20101001

• Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses.

  Gastroenterology 20101001

• Evolution of drug resistance during 48 weeks of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoring.

  Journal of acquired immune deficiency syndromes (1999) 20101001

• The impact of gender and anchor drugs on TDF renal toxicity.

  Journal of acquired immune deficiency syndromes (1999) 20101001

• Systemic preexposure prophylaxis for human immunodeficiency virus infection.

  Pharmacotherapy 20101001

• Selective determination of antiretroviral agents tenofovir, emtricitabine, and lamivudine in human plasma by a LC-MS-MS method for a bioequivalence study in healthy Indian subjects.

  Journal of chromatographic science 20101001

• Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.

  Expert review of anti-infective therapy 20101001

• Efficacy and safety of entecavir and/or tenofovir for prophylaxis and treatment of hepatitis B recurrence post-liver transplant.

  Transplantation proceedings 20101001

• Incidence and risk factors for tenofovir-associated renal function decline among Thai HIV-infected patients with low-body weight.

  Current HIV research 20101001

• Inflammatory bowel disease and hepatitis B and C in Western Balkans: a referral centre study and review of the literature.

  Journal of Crohn's & colitis 20101001

• Lower arterial stiffness and Framingham score after switching abacavir to tenofovir in men at high cardiovascular risk.

  AIDS (London, England) 20100924

• Tolerability of HIV postexposure prophylaxis with tenofovir/emtricitabine and lopinavir/ritonavir tablet formulation.

  AIDS (London, England) 20100924

• Immunodeficiency and renal impairment are risk factors for HIV-associated acute renal failure.

  AIDS (London, England) 20100910

• Associations of antiretroviral drug use and HIV-specific risk factors with carotid intima-media thickness.

  AIDS (London, England) 20100910

• Still a long wait for approved HIV-protective gel.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20100907

• Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

  Science (New York, N.Y.) 20100903

• Incomplete reversibility of tenofovir-related renal toxicity in HIV-infected men.

  Journal of acquired immune deficiency syndromes (1999) 20100901

• Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baseline.

  HIV medicine 20100901

• Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study.

  Journal of acquired immune deficiency syndromes (1999) 20100901

• Rapid HIV-RNA decline following addition of raltegravir and tenofovir to ongoing highly active antiretroviral therapy in a woman presenting with high-level HIV viraemia at week 38 of pregnancy.

  The Journal of antimicrobial chemotherapy 20100901

• High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.

  Journal of medical virology 20100901

• Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100901

• Trial results finally show potential for microbicidal HIV gel.

  The Lancet. Infectious diseases 20100901

• Prevention. Study reveals that vaginal gel reduces HIV, herpes.

  AIDS policy & law 20100901

• [Analogs combination therapy in chronic hepatitis B: when and how?].

  Gastroenterologie clinique et biologique 20100901

• [Long-term therapy for chronic hepatitis B in HIV co-infected patients].

  Gastroenterologie clinique et biologique 20100901

• [Treatment has a positive impact on the long-term evolution of chronic hepatitis B].

  Gastroenterologie clinique et biologique 20100901

• After CAPRISA 004: time to re-evaluate the HIV lexicon.

  Lancet (London, England) 20100814

• Drug therapy: tenofovir.

  Hepatology (Baltimore, Md.) 20100801

• Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.

  Journal of immunology (Baltimore, Md. : 1950) 20100801

• Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency.

  Journal of acquired immune deficiency syndromes (1999) 20100801

• Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users.

  AIDS research and human retroviruses 20100801

• Short communication: Comparable safety and efficacy with once-daily versus twice-daily dosing of lopinavir/ritonavir tablets with emtricitabine + tenofovir DF in antiretroviral-naïve, HIV type 1-infected subjects: 96 week final results of the randomized trial M05-730.

  AIDS research and human retroviruses 20100801

• The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues.

  Hepatology (Baltimore, Md.) 20100801

• [Antiviral treatment of chronic B hepatitis; 2010 - therapeutic recommendations].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20100801

• Antiretroviral vaginal gel shows promise against HIV.

  Lancet (London, England) 20100731

• HIV/AIDS. At last, vaginal gel scores victory against HIV.

  Science (New York, N.Y.) 20100723

• [Treatment of chronic hepatitis B. High response rate in general practice].

  MMW Fortschritte der Medizin 20100722

• A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206.

  AIDS (London, England) 20100717

• Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients.

  AIDS (London, England) 20100717

• Renal toxicity associated with tenofovir use.

  Expert opinion on drug safety 20100701

• Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.

  Antimicrobial agents and chemotherapy 20100701

• Analysis of resistance testing in South Trinidad.

  The West Indian medical journal 20100701

• Advantages of low-cost generic tenofovir instead of D4T for first-line antiretroviral therapy in Burma: a 2-year experience.

  AIDS (London, England) 20100619

• Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial.

  Archives of sexual behavior 20100601

• Near-infrared investigations of novel anti-HIV tenofovir liposomes.

  The AAPS journal 20100601

• Development of a validated liquid chromatographic method for the determination of related substances and assay of tenofovir disoproxil fumarate.

  Journal of separation science 20100601

• Gastrointestinal tolerability and quality of life in antiretroviral-naive HIV-1-infected patients: data from the CASTLE study.

  AIDS care 20100601

• [HIV-therapy-associated immune reconstitution syndrome presenting as immunogenic hyperthyroidism].

  Deutsche medizinische Wochenschrift (1946) 20100601

• Prevalence and factors associated with renal dysfunction among HIV-infected patients.

  AIDS patient care and STDs 20100601

• The exploitation of 'Exploitation' in the tenofovir prep trial in Cameroon: Lessons learned from media coverage of an HIV prevention trial.

  Journal of empirical research on human research ethics : JERHRE 20100601

• AZT or tenofovir for patients with the K65R mutation?

  Journal watch. AIDS clinical care 20100601

• Current therapeutic strategies for recurrent hepatitis B virus infection after liver transplantation.

  World journal of gastroenterology 20100528

• Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France.

  HIV medicine 20100501

• Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia.

  Journal of acquired immune deficiency syndromes (1999) 20100501

• Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon.

  Liver international : official journal of the International Association for the Study of the Liver 20100501

• [Hepatitis B reactivation in an HbsAg-negative/anti-HBc-positive patient with B-cell non-Hodgkin lymphoma receiving chemotherapy with rituximab].

  Gastroenterologia y hepatologia 20100501

• Recent FDA approvals and changes.

  AIDS patient care and STDs 20100501

• Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection.

  Health technology assessment (Winchester, England) 20100501

• Economic evaluation of ART in resource-limited countries.

  Current opinion in HIV and AIDS 20100501

• On-treatment monitoring of chronic hepatitis B virus infection: an Asian-Pacific perspective.

  Journal of gastroenterology and hepatology 20100501

• [Protease inhibitor or non-nucleoside reverse transcriptase inhibitor. ACTG study 5202 in focus].

  MMW Fortschritte der Medizin 20100429

• Emerging mutations at virological failure of HAART combinations containing tenofovir and lamivudine or emtricitabine.

  AIDS (London, England) 20100424

• Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations.

  AIDS (London, England) 20100424

• Tenofovir/probenecid combination in HIV/HBV-coinfected patients: how to escape Fanconi syndrome recurrence?

  AIDS (London, England) 20100424

• Efficacy of tenofovir-emtricitabine versus abacavir-lamivudine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100415

• [Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation].

  Medicina clinica 20100410

• Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion.

  Liver international : official journal of the International Association for the Study of the Liver 20100401

• Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.

  AIDS research and human retroviruses 20100401

• Tenofovir/emtricitabine combination results in lower bone-mineral density.

  AIDS patient care and STDs 20100401

• Report from the 17th Conference on Retroviruses and Opportunistic Infections. Randomized studies of once-daily darunavir and tenofovir/FTC + nevirapine.

  Journal watch. AIDS clinical care 20100401

• Tenofovir treatment of primary osteoblasts alters gene expression profiles: implications for bone mineral density loss.

  Biochemical and biophysical research communications 20100326

• Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients.

  AIDS (London, England) 20100313

• Safety and efficacy of tenofovir/emtricitabine plus nevirapine in HIV-infected patients.

  AIDS (London, England) 20100313

• A controlled trial of initial antiviral regimens for HIV-1 infection.

  The New England journal of medicine 20100304

• Steady-state amprenavir and tenofovir pharmacokinetics after coadministration of unboosted or ritonavir-boosted fosamprenavir with tenofovir disoproxil fumarate in healthy volunteers.

  HIV medicine 20100301

• Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study.

  Journal of acquired immune deficiency syndromes (1999) 20100301

• Switching the nucleoside reverse transcriptase inhibitor backbone to tenofovir disoproxil fumarate + emtricitabine promptly improves triglycerides and low-density lipoprotein cholesterol in dyslipidaemic patients.

  The Journal of antimicrobial chemotherapy 20100301

• Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100301

• The case: 41-year-old HIV patient with proteinuria and progressive renal dysfunction. Tenofovir toxicity.

  Kidney international 20100301

• Elvucitabine data released at CROI.

  AIDS patient care and STDs 20100301

• Findings in humanized-mouse model suggest benefit of further studies in HIV pre-exposure prophylaxis.

  Expert review of clinical immunology 20100301

• More research needed to find new HIV-suppressive functions of cytotoxic T cells.

  Immunotherapy 20100301

• Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case-control study.

  AIDS (London, England) 20100220

• Tenofovir and changes in renal function.

  AIDS (London, England) 20100220

• Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219

• Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir.

  The Journal of antimicrobial chemotherapy 20100201

• Cost-effectiveness of tenofovir as first-line antiretroviral therapy in India.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100201

• Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker.

  International journal of STD & AIDS 20100201

• Incidence of proximal renal tubular dysfunction in patients on tenofovir disoproxil fumarate.

  International journal of STD & AIDS 20100201

• Patient-reported outcomes in virologically suppressed, HIV-1-Infected subjects after switching to a simplified, single-tablet regimen of efavirenz, emtricitabine, and tenofovir DF.

  AIDS patient care and STDs 20100201

• Viral resistance in hepatitis B: prevalence and management.

  Current gastroenterology reports 20100201

• Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction.

  AIDS (London, England) 20100128

• N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations.

  AIDS (London, England) 20100116

• Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts.

  Biochemical and biophysical research communications 20100115

• Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.

  Science translational medicine 20100113

• Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008.

  Archives of internal medicine 20100111

• DAART for human immunodeficiency virus-infected patients: Studying subjects not at risk for nonadherence and use of untested interventions.

  Archives of internal medicine 20100111

• Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial.

  Lancet (London, England) 20100109

• [Protocol for the antiviral therapy of hepatitis B and D].

  Orvosi hetilap 20100103

• High rates of active hepatitis B and C co-infections in HIV-1 infected Cameroonian adults initiating antiretroviral therapy.

  HIV medicine 20100101

• Efficacy and safety of boosted and unboosted atazanavir-containing antiretroviral regimens in real life: results from a multicentre cohort study.

  HIV medicine 20100101

• Impact of tenofovir on renal function in HIV-infected, antiretroviral-naive patients.

  Journal of acquired immune deficiency syndromes (1999) 20100101

• Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100101

• Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues.

  Hepatology (Baltimore, Md.) 20100101

• Antiretroviral medications: adverse effects on the kidney.

  Advances in chronic kidney disease 20100101

• Acute urinary retention due to viral coinfections (HIV, HBV, VZV).

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101

• Tolerability of two different combinations of antiretroviral drugs including tenofovir used in occupational and nonoccupational postexposure prophylaxis for HIV.

  AIDS patient care and STDs 20100101

• Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.

  PloS one 20100101

• Interactions between buprenorphine and antiretrovirals: nucleos(t)ide reverse transcriptase inhibitors (NRTI) didanosine, lamivudine, and tenofovir.

  The American journal on addictions 20100101

• Effect of newer oral antiviral agents on future therapy of chronic hepatitis B.

  Antiviral therapy 20100101

• Mitochondrial changes during D-drug-containing once-daily therapy in HIV-positive treatment-naive patients.

  Antiviral therapy 20100101

• In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.

  PloS one 20100101

• Development of an LC-MS method for measuring TNF in human vaginal tissue.

  Journal of chromatographic science 20100101

• Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy.

  Retrovirology 20100101

• Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy.

  Antiviral therapy 20100101

• Positive and negative drug selection pressures on the N348I connection domain mutation: new insights from in vivo data.

  Antiviral therapy 20100101

• The effects of a nucleoside-sparing antiretroviral regimen on the pharmacokinetics of ritonavir-boosted darunavir in HIV type-1-infected patients.

  Antiviral therapy 20100101

• The effect of tenofovir disoproxil fumarate on whole-body insulin sensitivity, lipids and adipokines in healthy volunteers.

  Antiviral therapy 20100101

• [Use of a fixed-dose combination of Efavirenz-Emtricitabine-Tenofovir in a tertiary hospital].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20100101

• Analogs and fibrosis regression in hepatitis B.

  Gastroenterologie clinique et biologique 20100101

• Raltegravir, tenofovir, and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity.

  European journal of medical research 20100101

• Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.

  Antiviral therapy 20100101

• Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir.

  Antiviral therapy 20100101

• Rapid improvement in fasting lipids and hepatic toxicity after switching from didanosine/lamivudine to tenofovir/emtricitabine in patients with toxicity attributable to didanosine.

  HIV clinical trials 20100101

• Economic efficiency of genetic screening to inform the use of abacavir sulfate in the treatment of HIV.

  PharmacoEconomics 20100101

• Can I tell you the truth? A comparative perspective on regulating off-label scientific and medical information.

  Yale journal of health policy, law, and ethics 20100101

• Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults.

  Antiviral therapy 20100101

• Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone in antiretroviral-naive HIV-HBV coinfection in Thailand.

  Antiviral therapy 20100101

• Antiviral treatment including entecavir plus tenofovir disoproxil fumarate for HBV reactivation following a rituximab-based regimen.

  Antiviral therapy 20100101

• Tenofovir-associated severe bone pain: I cannot walk!

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101

• Liver fibrosis changes in HIV-HBV-coinfected patients: clinical, biochemical and histological effect of long-term tenofovir disoproxil fumarate use.

  Antiviral therapy 20100101

• Occult HBV infection in untreated HIV-infected adults in Côte d'Ivoire.

  Antiviral therapy 20100101

• Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youths.

  Antiviral therapy 20100101

• Effect of boosted fosamprenavir or lopinavir-based combinations on whole-body insulin sensitivity and lipids in treatment-naive HIV-type-1-positive men.

  Antiviral therapy 20100101

• Trials planned to confirm efficacy of tenofovir microbicide gel.

  IAVI report : newsletter on international AIDS vaccine research 20100101

• Let the sun shine in.

  Positively aware : the monthly journal of the Test Positive Aware Network 20100101

• Vaccine briefs.

  IAVI report : newsletter on international AIDS vaccine research 20100101

• The North Carolina contribution to the CAPRISA 004 study: the Global Health Initiative in action.

  North Carolina medical journal 20100101

• Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial.

  Lancet (London, England) 20091219

• Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.

  The Journal of biological chemistry 20091211

• Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy.

  The New England journal of medicine 20091203

• Once-daily treatment with saquinavir mesylate (2000 mg) and ritonavir (100 mg) together with a fixed-dose combination of abacavir/lamivudine (600/300 mg) or tenofovir/emtricitabine (245/200 mg) in HIV-1-infected patients.

  The Journal of antimicrobial chemotherapy 20091201

• Subclinical tubular injury in HIV-infected individuals on antiretroviral therapy: a cross-sectional analysis.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20091201

• A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate.

  Expert opinion on pharmacotherapy 20091201

• Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091115

• The art of managing human immunodeficiency virus infection: a balancing act.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091115

• Tenofovir disoproxil fumarate: in chronic hepatitis B.

  Drugs 20091112

• On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

• Modified directly observed therapy to improve HIV treatment outcomes: little impact with potent, once-daily therapy in unselected antiretroviral-naïve patients.

  Current HIV/AIDS reports 20091101

• Tenofovir coadministration is not associated with lower unboosted atazanavir plasma exposure in the clinical setting.

  Journal of acquired immune deficiency syndromes (1999) 20091101

• Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention.

  AIDS research and human retroviruses 20091101

• FDA notifications. FDA approves generic combination of efavirenz, lamivudine & tenofovir.

  AIDS alert 20091101

• [Acute renal failure and hypercalcemia in an AIDS patient on tenofovir and low-dose vitamin D therapy with immune reconstitution inflammatory syndrome].

  Medizinische Klinik (Munich, Germany : 1983) 20091015

• Atazanavir-related renal insufficiency without concurrent tenofovir.

  Enfermedades infecciosas y microbiologia clinica 20091001

• Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B.

  Journal of hepatology 20091001

• Development of HIV-1 drug resistance through 144 weeks in antiretroviral-naïve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934.

  Journal of acquired immune deficiency syndromes (1999) 20091001

• Effectiveness of antiretroviral regimens containing abacavir with tenofovir in treatment-experienced patients: predictors of virological response and drug resistance evolution in a multi-cohort study.

  Infection 20091001

• Conserved T cell and natural killer cell function in treatment-experienced adults receiving tenofovir plus didanosine as nucleoside reverse transcription inhibitor backbone.

  Clinical and experimental immunology 20091001

• Effects of nucleoside reverse transcriptase inhibitor backbone on the efficacy of first-line boosted highly active antiretroviral therapy based on protease inhibitors: meta-regression analysis of 12 clinical trials in 5168 patients.

  HIV medicine 20091001

• Tenofovir for the treatment of hepatitis B virus.

  Pharmacotherapy 20091001

• Pharmacogenetics of tenofovir treatment.

  Pharmacogenomics 20091001

• [The efficacy of nucleoside/nucleotide analogue on chronic hepatitis B].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20091001

• FDA notifications. Generic efavirenz/emtricitabine/fenofovir has tentative approval.

  AIDS alert 20091001

• Renal function with use of a tenofovir-containing initial antiretroviral regimen.

  AIDS (London, England) 20090924

• Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial.

  Lancet (London, England) 20090905

• Tenofovir-associated renal and bone toxicity.

  HIV medicine 20090901

• Virological response to initial antiretroviral regimens containing abacavir or tenofovir.

  The Journal of infectious diseases 20090901

• Chronic hepatitis B: update 2009.

  Hepatology (Baltimore, Md.) 20090901

• The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients.

  Expert review of anti-infective therapy 20090901

• [Tenofovir, An antiviral agent with activity against HIV infections and hepatitis B].

  Revue de l'infirmiere 20090901

• [Efficacy and safety of TAM-sparing antiretroviral regimens in naïve HIV-positive patients].

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090901

• Tenofovir disoproxil fumarate for the treatment of hepatitis B infection.

  Drugs of today (Barcelona, Spain : 1998) 20090901

• Microbicide research already benefiting thousands--experts.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20090901

• A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals.

  Journal of acquired immune deficiency syndromes (1999) 20090815

• Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.

  The Journal of infectious diseases 20090815

• Tenofovir disoproxil fumarate in pregnancy and prevention of mother-to-child transmission of HIV-1: is it time to move on from zidovudine?

  HIV medicine 20090801

• Renal function in patients with preexisting renal disease receiving tenofovir-containing highly active antiretroviral therapy in the HIV outpatient study.

  AIDS patient care and STDs 20090801

• The absence of HIV mutations in cerebrospinal fluid and in peripheral blood mononuclear cells during a regimen containing Trizivir plus tenofovir.

  Journal of chemotherapy (Florence, Italy) 20090801

• Lack of effect of tenofovir disoproxil fumarate on pharmacokinetics of hormonal contraceptives.

  Pharmacotherapy 20090801

• Raltegravir as effective as efavirenz in 144-week data.

  AIDS patient care and STDs 20090801

• HIV therapy may be given safely in resource-limited settings without routine laboratory monitoring.

  AIDS patient care and STDs 20090801

• Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives.

  Nucleosides, nucleotides & nucleic acids 20090801

• Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.

  AIDS (London, England) 20090731

• HIV clinics are halting enrolment of new patients as funding stalls, MSF warns.

  BMJ (Clinical research ed.) 20090720

• Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trial.

  Archives of internal medicine 20090713

• Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility.

  Chinese medical journal 20090705

• The rise and fall of K65R in a Portuguese HIV-1 Drug Resistance database, despite continuously increasing use of tenofovir.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20090701

• Spectrum of chronic kidney disease in HIV-infected patients.

  HIV medicine 20090701

• A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression.

  Journal of acquired immune deficiency syndromes (1999) 20090701

• A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients.

  The Journal of antimicrobial chemotherapy 20090701

• Reduced glomerular filtration rate but sustained virologic response in HIV/hepatitis B co-infected individuals on long-term tenofovir.

  Journal of viral hepatitis 20090701

• Improvements in cheek volume in lipoatrophic individuals switching away from thymidine nucleoside reverse transcriptase inhibitors.

  HIV medicine 20090701

• The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically labeled internal standards.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090701

• Modulation of K65R selection by zidovudine inclusion: analysis of HIV resistance selection in subjects with virologic failure receiving once-daily abacavir/lamivudine/zidovudine and tenofovir DF (study COL40263).

  AIDS research and human retroviruses 20090701

• Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats.

  Journal of acquired immune deficiency syndromes (1999) 20090701

• Weight evolution in HIV-1 infected women in Rwanda after stavudine substitution due to lipoatrophy: comparison of zidovudine with tenofovir/abacavir.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20090601

• Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen.

  The Journal of antimicrobial chemotherapy 20090601

• Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients.

  Journal of acquired immune deficiency syndromes (1999) 20090601

• Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues.

  Current opinion in organ transplantation 20090601

• Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090601

• [Renal tuberculosis and human immunodeficiency virus infection].

  Enfermedades infecciosas y microbiologia clinica 20090601

• Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.

  Bioorganic & medicinal chemistry 20090601

• Safety evaluation of 1% tenofovir gel in healthy men.

  International journal of STD & AIDS 20090601

• Long-term suppressive therapy for pulmonary aspergilloma in an immunocompromised man with AIDS. Is it always necessary?

  International journal of STD & AIDS 20090601

• Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.

  Electrophoresis 20090601

• FDA notifications. Tenofovir in India receives tentative approval.

  AIDS alert 20090601

• Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare.

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090601

• Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible.

  Prescrire international 20090601

• Tenofovir: new indication. In chronic hepatitis B: beware bone toxicity.

  Prescrire international 20090601

• [Therapy of chronic hepatitis B. Tenofovir--first choice in current EASL guidelines].

  MMW Fortschritte der Medizin 20090528

• Substituting tenofovir for stavudine in resource-limited settings: there are challenges ahead.

  AIDS (London, England) 20090515

• Comment on: High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients.

  The Journal of antimicrobial chemotherapy 20090501

• Long-term outcome of tenofovir disoproxil fumarate use against hepatitis B in an HIV-coinfected cohort.

  HIV medicine 20090501

• [New molecules in the treatment of chronic hepatitis B].

  Presse medicale (Paris, France : 1983) 20090501

• Tenofovir renal toxicity targets mitochondria of renal proximal tubules.

  Laboratory investigation; a journal of technical methods and pathology 20090501

• Generic Truvada approved.

  AIDS patient care and STDs 20090501

• Emergency transplantation for acute reactivation of chronic hepatitis B with high viral load: role of antiviral therapy.

  Liver international : official journal of the International Association for the Study of the Liver 20090501

• Rhabdomyolysis in an HIV-infected patient on anti-retroviral therapy precipitated by high-dose pravastatin.

  Current drug safety 20090501

• Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only?

  Current HIV research 20090501

• Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.

  Clinical nephrology 20090501

• Rationing antiretroviral therapy in Africa--treating too few, too late.

  The New England journal of medicine 20090430

• [Current data on antiretroviral therapy. CROI 2009: tenofovir DR convinces by high effectiveness and tolerance].

  MMW Fortschritte der Medizin 20090430

• Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent vertical transmission of HIV-1.

  AIDS (London, England) 20090427

• Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC) co-formulation (Truvada) in virologically suppressed HIV-infected patients on HAART.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20090401

• Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor efavirenz, a nucleoside reverse transcriptase inhibitor emtricitabine and a nucleotide reverse transcriptase inhibitor tenofovir in plasma by liquid chromatography positive ion electrospray tandem mass spectrometry.

  Biomedical chromatography : BMC 20090401

• Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy.

  Hepatology (Baltimore, Md.) 20090401

• Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations.

  HIV medicine 20090401

• Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice.

  Journal of hepatology 20090401

• The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.

  Hepatology (Baltimore, Md.) 20090401

• Decision analysis model for hepatitis B prophylaxis one year after liver transplantation.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20090401

• FDA approves three generics.

  AIDS patient care and STDs 20090401

• Progressive renal tubular dysfunction associated with long-term use of tenofovir DF.

  AIDS research and human retroviruses 20090401

• Gilead is going strong.

  Fortune 20090330

• Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir.

  AIDS (London, England) 20090327

• HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090315

• Assessment of the steady-state pharmacokinetic interaction between etravirine administered as two different formulations and tenofovir disoproxil fumarate in healthy volunteers.

  HIV medicine 20090301

• Tenofovir use in human immunodeficiency virus-1-infected children in the United kingdom and Ireland.

  The Pediatric infectious disease journal 20090301

• Bone pain due to fractures revealing osteomalacia related to tenofovir-induced proximal renal tubular dysfunction in a human immunodeficiency virus-infected patient.

  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090301

• Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20090301

• Successful treatment of refractory Behçet's disease with the TNF-alpha blocker infliximab.

  Iranian journal of immunology : IJI 20090301

• Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases.

  The AIDS reader 20090301

• Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice.

  The AIDS reader 20090301

• Hepatitis B in HIV patients: what is the current treatment and what are the challenges?

  Journal of HIV therapy 20090301

• Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.

  World journal of gastroenterology 20090214

• Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109).

  Clinical pharmacology and therapeutics 20090201

• Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.

  Antiviral research 20090201

• High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients.

  The Journal of antimicrobial chemotherapy 20090201

• Glomerular filtration rates in HIV-infected patients treated with and without tenofovir: a prospective, observational study.

  The Journal of antimicrobial chemotherapy 20090201

• Hepatitis B virus viral load and treatment decision.

  Hepatology (Baltimore, Md.) 20090201

• A preemptive strike against HIV.

  Nature medicine 20090201

• Rapid and specific liquid chromatographic tandem mass spectrometric determination of tenofovir in human plasma and its fragmentation study.

  Journal of chromatographic science 20090201

• [Atazanavir-induced nephrolithiasis].

  Enfermedades infecciosas y microbiologia clinica 20090201

• HIV-1 infection of human penile explant tissue and protection by candidate microbicides.

  AIDS (London, England) 20090128

• Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals.

  The Cochrane database of systematic reviews 20090121

• Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090115

• Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients.

  AIDS (London, England) 20090114

• Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient.

  AIDS (London, England) 20090114

• Hepatitis B and liver transplantation: 2008 update.

  Reviews in medical virology 20090101

• Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.

  Antimicrobial agents and chemotherapy 20090101

• Sensitivity of phenotypic susceptibility analyses for nonthymidine nucleoside analogues conferred by K65R or M184V in mixtures with wild-type HIV-1.

  The Journal of infectious diseases 20090101

• Application of UV-spectrophotometric methods for estimation of tenofovir disoproxil fumarate in tablets.

  Pakistan journal of pharmaceutical sciences 20090101

• Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.

  AIDS patient care and STDs 20090101

• HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues.

  Liver international : official journal of the International Association for the Study of the Liver 20090101

• Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance.

  Retrovirology 20090101

• Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues.

  Antiviral chemistry & chemotherapy 20090101

• Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.

  Antiviral therapy 20090101

• Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure.

  Antiviral therapy 20090101

• The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.

  Retrovirology 20090101

• Emtricitabine/tenofovir disoproxil fumarate: in combination with a protease inhibitor in HIV-1 infection.

  Drugs 20090101

• Changes in hematological parameters after switching treatment of HIV-infected patients from zidovudine to abacavir or tenofovir DF.

  HIV clinical trials 20090101

• Switch from a ZDV/3TC-based regimen to a completely once daily (QD) regimen of emtricitabine/tenofovir DF fixed dose combination plus a third QD agent (SONETT).

  European journal of medical research 20090101

• Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys.

  Molecular pharmaceutics 20090101

• Steady-state amprenavir, tenofovir, and emtricitabine pharmacokinetics before and after reducing ritonavir boosting of a fosamprenavir/tenofovir/emtricitabine regimen from 200 mg to 100 mg once daily (TELEX II).

  HIV clinical trials 20090101

• Analogs and fibrosis regression in hepatitis B.

  Gastroenterologie clinique et biologique 20090101

• Acute renal failure in patients with AIDS on tenofovir while receiving prolonged vancomycin course for osteomyelitis.

  The AIDS reader 20090101

• Editorial comment: mixing tenofovir with other nephrotoxins--how safe is this?

  The AIDS reader 20090101

• Expert review of drug patent applications: improving health in the developing world.

  Health affairs (Project Hope) 20090101

• Primary HIV-1 drug resistance and polymorphic patterns among injecting drug users (IDUs) in Chennai, Southern India.

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101

• Tenofovir-emtricitabine-efavirenz in HIV-I-infected adults in Senegal: a 96-week pilot trial in treatment-naive patients.

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101

• [Budget impact of a set-dose combination of efavirenz-emtricitabine-tenofovir in the treatment of patients infected with HIV-1].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

• Lower limb high arterial flow induced by tenofovir and emtricitabine treatment.

  Antiviral therapy 20090101

• Viral load decay in antiretroviral-naïve patients receiving once-daily tenofovir and emtricitabine plus twice-daily nevirapine.

  HIV clinical trials 20090101

• Safety and efficacy of once-daily nevirapine dosing: a multicohort study.

  Antiviral therapy 20090101

• Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months.

  Antiviral therapy 20090101

• Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety.

  Antiviral therapy 20090101

• Tenofovir-induced osteomalacia.

  Clinical and experimental rheumatology 20090101

• Long-term efficacy and safety of once-daily nevirapine in combination with tenofovir and emtricitabine in the treatment of HIV-infected patients: a 72-week prospective multicenter study (TENOR-trial).

  European journal of medical research 20090101

• [Protocol for the antiviral therapy of chronic hepatitis B].

  Orvosi hetilap 20081207

• Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.

  The New England journal of medicine 20081204

• Chronic hepatitis B--new goals, new treatment.

  The New England journal of medicine 20081204

• Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance.

  Clinical pharmacology and therapeutics 20081201

• A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20081201

• Efficacy of pegylated interferon plus ribavirin treatment in HIV/hepatitis C virus co-infected patients receiving abacavir plus lamivudine or tenofovir plus either lamivudine or emtricitabine as nucleoside analogue backbone.

  The Journal of antimicrobial chemotherapy 20081201

• Disinhibition and risk compensation: scope, definitions, and perspective.

  Sexually transmitted diseases 20081201

• Kidney disease in patients with HIV infection and AIDS.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081201

• Pharmacokinetics of emtricitabine/tenofovir disoproxil fumarate and tacrolimus at steady state when administered alone or in combination.

  International journal of clinical pharmacology and therapeutics 20081201

• Changes in sexual risk behavior among participants in a PrEP HIV prevention trial.

  Sexually transmitted diseases 20081201

• Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study.

  Journal of pharmaceutical and biomedical analysis 20081104

• Determinants of high-risk sexual behavior during post-exposure prophylaxis to prevent HIV infection.

  AIDS and behavior 20081101

• The discovery of antiviral agents: ten different compounds, ten different stories.

  Medicinal research reviews 20081101

• Human immunodeficiency virus-induced uveitis: intraocular and plasma human immunodeficiency virus-1 RNA loads.

  Ophthalmology 20081101

• Population pharmacokinetics of tenofovir in AIDS patients.

  Journal of clinical pharmacology 20081101

• Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy?

  Journal of hepatology 20081101

• Adverse effects of tenofovir use in HIV-infected pregnant women and their infants.

  The Annals of pharmacotherapy 20081101

• Two-year data released on Viread for chronic hepatitis B.

  AIDS patient care and STDs 20081101

• 96-week CASTLE data show similar efficacy results.

  AIDS patient care and STDs 20081101

• [A case of acute renal failure involving high amounts of tenofovir after HAART start].

  Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20081101

• [Chronic hepatitis B: current therapy].

  Bulletin de l'Academie nationale de medecine 20081101

• Low trough levels of tipranavir in a combination antiretroviral therapy of tipranavir/ritonavir and tenofovir require therapeutic drug monitoring.

  European journal of medical research 20081027

• Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.

  European journal of medical research 20081027

• The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients.

  AIDS (London, England) 20081018

• Rosiglitazone reverses tenofovir-induced nephrotoxicity.

  Kidney international 20081001

• A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand.

  Hepatology (Baltimore, Md.) 20081001

• Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course.

  Journal of acquired immune deficiency syndromes (1999) 20081001

• Combination antiretroviral therapy with tenofovir, emtricitabine or lamivudine, and nevirapine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081001

• The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.

  AIDS (London, England) 20081001

• [Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic perspectives, in patients naïve and in subjects pre-treated with antiretrovirals].

  Recenti progressi in medicina 20081001

• Tenofovir-associated decline in renal function.

  The Journal of infectious diseases 20080915

• Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s.

  Journal of the American College of Cardiology 20080812

• Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.

  HIV medicine 20080801

• The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.

  Journal of acquired immune deficiency syndromes (1999) 20080801

• Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: successful rescue therapy with tenofovir.

  European journal of gastroenterology & hepatology 20080801

• Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.

  PLoS medicine 20080801

• Can a topical microbicide prevent rectal HIV transmission?

  PLoS medicine 20080801

• Tenofovir: what have over 1 million years of patient experience taught us?

  International journal of clinical practice 20080801

• CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load.

  The AIDS reader 20080801

• Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis.

  Liver international : official journal of the International Association for the Study of the Liver 20080701

• Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.

  Molecular pharmacology 20080701

• Review article: current antiviral therapy of chronic hepatitis B.

  Alimentary pharmacology & therapeutics 20080701

• Cost and cost-effectiveness of switching from stavudine to tenofovir in first-line antiretroviral regimens in South Africa.

  Journal of acquired immune deficiency syndromes (1999) 20080701

• A new assay based on solid-phase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients.

  Journal of chromatographic science 20080701

• Zidovudine/lamivudine/abacavir plus tenofovir in HIV-infected naive patients: a 96-week prospective one-arm pilot study.

  AIDS research and human retroviruses 20080701

• Genetic basis of variation in tenofovir drug susceptibility in HIV-1.

  AIDS (London, England) 20080619

• Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy.

  The Journal of antimicrobial chemotherapy 20080601

• Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080601

• Switch from ritonavir-boosted to unboosted atazanavir guided by therapeutic drug monitoring.

  AIDS research and human retroviruses 20080601

• Addition of single-dose tenofovir and emtricitabine to intrapartum nevirapine to reduce perinatal HIV transmission.

  Journal of acquired immune deficiency syndromes (1999) 20080601

• [Introduction. Tenofovir].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Tenofovir: pharmacology and interactions].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Clinical data I. Clinical experience with tenofovir in combination with nonnucleoside analogue transcriptase inhibitors].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Clinical data II. Clinical experience of tenofovir DF in combination with protease inhibitors].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Tenofovir as a strategy to avoid or limit adverse effects].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Tenofovir DF in rescue regimens].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Role of tenofovir in HIV and hepatitis C virus coinfection].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Are all analogue combinations equal?].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Management of renal toxicity in HIV-positive patients. What to measure, how to measure it and how frequently].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Conclusions. Tenofovir].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Current role of tenofovir in clinical medicine].

  Enfermedades infecciosas y microbiologia clinica 20080601

• [Chronic hepatitis B. Tenofovir--the right choice from the beginning].

  MMW Fortschritte der Medizin 20080522

• [Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients].

  MMW Fortschritte der Medizin 20080522

• Does tenofovir increase efavirenz hepatotoxicity?

  AIDS (London, England) 20080511

• Experience with tenofovir disoproxil fumarate for antiretroviral therapy.

  Expert opinion on pharmacotherapy 20080501

• [Acute renal failure associated with the use of tenofovir combined with atazanavir in patients with HIV infection].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [Severe hypokalemia and tenofovir].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [Resistance in hepatitis B virus].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [Clinical management of patients with chronic hepatitis B virus infection].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [Hepatitis B in patients with HIV infection].

  Enfermedades infecciosas y microbiologia clinica 20080501

• [First line therapy. Tenofovir DF/emtricitabine--the potent backbone].

  MMW Fortschritte der Medizin 20080428

• Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080415

• Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma.

  Clinical pharmacology and therapeutics 20080401

• Tenofovir DF plus lamivudine or emtricitabine for nonoccupational postexposure prophylaxis (NPEP) in a Boston Community Health Center.

  Journal of acquired immune deficiency syndromes (1999) 20080401

• Recent availability of two novel, fixed formulations of antiretroviral nucleoside analogues: a 12-month prospective, open-label survey of their practical use and therapeutic perspectives in antiretroviral-naive and -experienced patients.

  AIDS patient care and STDs 20080401

• Acceptability of tenofovir gel as a vaginal microbicide among women in a phase I trial: a mixed-methods study.

  Journal of women's health (2002) 20080401

• The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.

  British journal of clinical pharmacology 20080401

• Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus.

  The Journal of pediatrics 20080401

• Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques.

  AIDS research and human retroviruses 20080401

• Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

  Nucleosides, nucleotides & nucleic acids 20080401

• An open-label pilot study to determine the efficacy of lopinavir/ritonavir and tenofovir DF in the treatment of HIV-infected patients experiencing first virologic failure on a non-nucleoside-based regimen.

  AIDS patient care and STDs 20080401

• Europe extends Viread indication for chronic hepatitis B.

  AIDS patient care and STDs 20080401

• Risk of early virological failure of once-daily tenofovir-emtricitabine plus twice-daily nevirapine in antiretroviral therapy-naive HIV-infected patients.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

• Test of new vaginal microbicide gel show promise for women.

  The AIDS reader 20080401

• [AIDS: ethics and scientific investigation on human beings].

  Bulletin de la Societe de pathologie exotique (1990) 20080401

• Abacavir/3TC vs. tenofovir/FTC: interim results from ACTG 5202.

  AIDS clinical care 20080401

• Potency of tenofovir in chronic hepatitis B: mono or combination therapy?

  Journal of hepatology 20080301

• The pharmacokinetics and viral activity of tenofovir in the male genital tract.

  Journal of acquired immune deficiency syndromes (1999) 20080301

• Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations.

  Journal of hepatology 20080301

• Kidney biopsy in HIV: beyond HIV-associated nephropathy.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20080301

• Syncope as a probable side effect to combination antiretroviral therapy initiated during primary HIV-1 infection.

  Sexual health 20080301

• Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients.

  Journal of acquired immune deficiency syndromes (1999) 20080301

• pH-dependent interactions of indinavir and lipids in nanoparticles and their ability to entrap a solute.

  Journal of pharmaceutical sciences 20080201

• The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients.

  Clinical pharmacology and therapeutics 20080201

• Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells.

  Journal of mass spectrometry : JMS 20080201

• Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection.

  Antimicrobial agents and chemotherapy 20080201

• Minor emtricitabine intolerance in treatment-stable patients switched from tenofovir/lamivudine to a fixed-dose combination of tenofovir/emtricitabine (Truvada).

  The Journal of antimicrobial chemotherapy 20080201

• Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080201

• Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression.

  Journal of viral hepatitis 20080201

• Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.

  PLoS medicine 20080201

• Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system.

  AIDS patient care and STDs 20080201

• Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients.

  Clinical therapeutics 20080201

• Urolithiasis under atazanavir boosted and tenofovir therapy: a case report.

  Journal of chemotherapy (Florence, Italy) 20080201

• Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors.

  European journal of pharmacology 20080128

• [Anti-viral therapy of type B chronic hepatitis. 3. Future of anti-viral agents].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20080110

• Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection.

  AIDS (London, England) 20080102

• Tenofovir renal safety in HIV-infected patients: results from the SCOLTA Project.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080101

• In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.

  Physiological research 20080101

• Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis.

  Journal of acquired immune deficiency syndromes (1999) 20080101

• Treatment options for lipodystrophy in HIV-positive patients.

  Expert opinion on pharmacotherapy 20080101

• Effects of the change from Stavudine to tenofovir in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy: studies on mitochondrial toxicity and thymic function.

  The Pediatric infectious disease journal 20080101

• Tenofovir nephrotoxicity: focusing research questions and putting them into clinical context.

  The Journal of infectious diseases 20080101

• Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy.

  The Journal of infectious diseases 20080101

• Can the new humanized mouse model give HIV research a boost.

  PLoS medicine 20080101

• Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice.

  PLoS medicine 20080101

• Plasma HIV load and proviral DNA decreases after two standard antiretroviral regimens in HIV-positive patients naïve to antiretrovirals.

  Current HIV research 20080101

• Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.

  Journal of neurovirology 20080101

• Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

  Antiviral therapy 20080101

• FDA grants tentative approval to first generic version of antiretroviral Viread.

  AIDS patient care and STDs 20080101

• European Commission approves Atripla.

  AIDS patient care and STDs 20080101

• Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV.

  HIV clinical trials 20080101

• Impact of switching virologically suppressed, HIV-1-infected patients from twice-daily fixed-dose zidovudine/lamivudine to once-daily fixed-dose tenofovir disoproxil fumarate/emtricitabine.

  HIV clinical trials 20080101

• Partial immunological and mitochondrial recovery after reducing didanosine doses in patients on didanosine and tenofovir-based regimens.

  Antiviral therapy 20080101

• FDA notifications. FDA's tentative approval for generic Tenofovir.

  AIDS alert 20080101

• Evidence of long-term suppression of hepatitis B virus DNA by tenofovir as rescue treatment in patients coinfected by HIV.

  Antiviral therapy 20080101

• Treatment of chronic hepatitis B infection: an update of Swedish recommendations.

  Scandinavian journal of infectious diseases 20080101

• Evaluation of efficacy, safety, pharmacokinetics, and adherence in HIV-1-infected, antiretroviral-naïve patients treated with ritonavir-boosted atazanavir plus fixed-dose tenofovir DF/emtricitabine given once daily.

  HIV clinical trials 20080101

• 'White coat compliance' limits the reliability of therapeutic drug monitoring in HIV-1-infected patients.

  HIV clinical trials 20080101

• Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.

  Antiviral therapy 20080101

• Effect of tenofovir subtraction on HIV plasma viraemia, CD4+ T-cell count and resistance in a patient with baseline K65R and M184V mutations.

  Antiviral therapy 20080101

• Renal dysfunction and tenofovir toxicity in HIV-infected patients.

  Topics in HIV medicine : a publication of the International AIDS Society, USA 20080101

• Pharmacotherapy of hepatitis B infection: a brief review.

  Nephrology nursing journal : journal of the American Nephrology Nurses' Association 20080101

• Effectiveness and safety of generic fixed-dose combination of tenofovir/emtricitabine/efavirenz in HIV-1-infected patients in Western India.

  Medscape journal of medicine 20080101

• [Drugs treatment of hepatitis B].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20080101

• No residual activity of raltegravir after development of 148 complex mutations in vivo.

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20080101

• Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.

  Best practice & research. Clinical gastroenterology 20080101

• Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort Study.

  Antiviral therapy 20080101

• Improvements in subcutaneous fat, lipid profile, and parameters of mitochondrial toxicity in patients with peripheral lipoatrophy when stavudine is switched to tenofovir (LIPOTEST study).

  HIV clinical trials 20080101

• Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.

  Bioorganic & medicinal chemistry letters 20071215

• Observational study on HIV-infected subjects failing HAART receiving tenofovir plus didanosine as NRTI backbone.

  Infection 20071201

• Congenital pyelectasis in children born from mothers on tenofovir containing therapy during pregnancy: report of two cases.

  Infection 20071201

• Resistance testing methodologies and mechanisms of resistance.

  Journal of HIV therapy 20071201

• Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B.

  Journal of HIV therapy 20071201

• Selection of L74V mutation in reverse transcriptase of HIV-1 subtype D by a tenofovir DF-lamivudine based regimen.

  AIDS (London, England) 20071130

• Reply to Crane et al., 'Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir'.

  AIDS (London, England) 20071130

• Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.

  Lancet (London, England) 20071117

• Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase.

  AIDS (London, England) 20071112

• Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers.

  British journal of clinical pharmacology 20071101

• Acute renal failure in HIV patients.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071001

• Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.

  Antiviral research 20071001

• Tenofovir comedication does not impair the steady-state pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected adults.

  European journal of clinical pharmacology 20071001

• Bioequivalence of efavirenz/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen.

  Journal of acquired immune deficiency syndromes (1999) 20071001

• Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine.

  Journal of acquired immune deficiency syndromes (1999) 20071001

• Predictors and kinetics of occult hepatitis B virus infection in HIV-infected persons.

  Journal of medical virology 20071001

• Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study.

  Journal of acquired immune deficiency syndromes (1999) 20071001

• Is phosphatemia the best tool to monitor renal tenofovir toxicity?

  Journal of acquired immune deficiency syndromes (1999) 20071001

• Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.

  Therapeutic drug monitoring 20071001

• Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir.

  The Pediatric infectious disease journal 20071001

• Female-initiated prevention strategies key to tackling HIV.

  The Lancet. Infectious diseases 20071001

• Tenofovir resistance among HIV-infected patients failing a fixed-dose combination of stavudine, lamivudine, and nevirapine in a resource-limited setting.

  AIDS patient care and STDs 20071001

• Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis.

  AIDS (London, England) 20070912

• Diverse approaches useful for microbicide trials.

  Nature 20070906

• Molecular basis of antagonism between K70E and K65R tenofovir-associated mutations in HIV-1 reverse transcriptase.

  Antiviral research 20070901

• Renal function in Tenofovir-exposed and Tenofovir-unexposed patients receiving highly active antiretroviral therapy in the HIV Outpatient Study.

  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20070901

• Adverse events experienced by three children taking tenofovir and didanosine in combination.

  HIV medicine 20070901

• Pregnancy prevention practices among women with multiple partners in an HIV prevention trial.

  Journal of acquired immune deficiency syndromes (1999) 20070901

• Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070901

• HIV-1 infection and the kidney: an evolving challenge in HIV medicine.

  Mayo Clinic proceedings 20070901

• Determination of plasma tenofovir concentrations using a conventional LC-MS method.

  Biological & pharmaceutical bulletin 20070901

• Acceptability of tenofovir gel as a vaginal microbicide by US male participants in a Phase I clinical trial (HPTN 050).

  AIDS care 20070901

• Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase.

  Journal of acquired immune deficiency syndromes (1999) 20070815

• Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B.

  World journal of gastroenterology 20070814

• Lopinavir/Ritonavir pharmacokinetic profile: impact of sex and other covariates following a change from twice-daily to once-daily therapy.

  Journal of clinical pharmacology 20070801

• Compromised immunologic recovery in patients receiving tipranavir/ritonavir coadministered with tenofovir and didanosine in Randomized Evaluation of Strategic Intervention in multidrug-resiStant patients with tipranavir (RESIST) studies.

  Journal of acquired immune deficiency syndromes (1999) 20070801

• Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy.

  Journal of medical primatology 20070801

• Direct stringency comparison of two macaque models (single-high vs. repeat-low) for mucosal HIV transmission using an identical anti-HIV chemoprophylaxis intervention.

  Journal of medical primatology 20070801

• Second tenofovir phase III study for the chronic HBV reaches primary endpoint.

  AIDS patient care and STDs 20070801

• Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase.

  AIDS (London, England) 20070711

• Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir.

  AIDS (London, England) 20070711

• Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate.

  AIDS (London, England) 20070711

• Effect of tenofovir on renal glomerular and tubular function.

  AIDS (London, England) 20070711

• Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report.

  AIDS (London, England) 20070711

• Pre-exposure prophylaxis for HIV infection: what if it works?

  Lancet (London, England) 20070707

• A second chance for microbicides.

  Lancet (London, England) 20070707

• Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137.

  Journal of acquired immune deficiency syndromes (1999) 20070701

• Relevance of a combined UV and single mass spectrometry detection for the determination of tenofovir in human plasma by HPLC in therapeutic drug monitoring.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

• The first once-daily single-tablet regimen for the treatment of HIV-infected patients.

  Drugs of today (Barcelona, Spain : 1998) 20070701

• Tenofovir gel--the new HIV prevention 'banker'?

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20070701

• [Hypophosphatemia and multiple fractures in patient with human immunodeficiency virus infection treated with tenofovir].

  Medicina clinica 20070630

• The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years.

  AIDS (London, England) 20070619

• Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey.

  AIDS (London, England) 20070619

• Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir.

  AIDS (London, England) 20070619

• Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases.

  AIDS (London, England) 20070619

• Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects.

  AIDS (London, England) 20070619

• CD4+ T cell evolution and predictors of its trend before and after tenofovir/didanosine backbone in the presence of sustained undetectable HIV plasma viral load.

  The Journal of antimicrobial chemotherapy 20070601

• Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies.

  Virchows Archiv : an international journal of pathology 20070601

• Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers.

  Journal of clinical pharmacology 20070601

• Assessment of adverse events associated with antiretroviral regimens for postexposure prophylaxis for occupational and nonoccupational exposures to prevent transmission of human immunodeficiency virus.

  Infection control and hospital epidemiology 20070601

• HPV oral infection. Case report of an HIV-positive Nigerian sex worker.

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070601

• Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome.

  The AIDS reader 20070601

• Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function.

  The AIDS reader 20070601

• Chronic renal failure among HIV-1-infected patients.

  AIDS (London, England) 20070531

• Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System.

  AIDS (London, England) 20070531

• Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein.

  Biochemical pharmacology 20070515

• Possible allergic cross-reaction to didanosine and tenofovir in an HIV-1-infected woman.

  AIDS (London, England) 20070511

• No response to first-line tenofovir+lamivudine+efavirenz despite optimization according to baseline resistance testing: impact of resistant minority variants on efficacy of low genetic barrier drugs.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070501

• No change in calculated creatinine clearance after tenofovir initiation among Thai patients.

  The Journal of antimicrobial chemotherapy 20070501

• Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.

  The Journal of infectious diseases 20070501

• Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.

  Journal of acquired immune deficiency syndromes (1999) 20070501

• Could tenofovir modify the model end-stage liver disease (MELD) score in patients with end-stage liver disease eligible for liver transplantation?

  Journal of acquired immune deficiency syndromes (1999) 20070501

• Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression.

  AIDS (London, England) 20070423

• Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.

  Biochemical pharmacology 20070401

• Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir.

  The Journal of antimicrobial chemotherapy 20070401

• Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).

  Pharmaceutical research 20070401

• Tenofovir and abacavir combination therapy: lessons learned from an urban clinic population.

  AIDS patient care and STDs 20070401

• Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT.

  AIDS (London, England) 20070330

• Hepatitis B reverse seroconversion in HIV-positive patients: case series and review of the literature.

  AIDS (London, England) 20070330

• Response to Schmutz et al., 'Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection'.

  AIDS (London, England) 20070330

• Response to Blaas et al., 'Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases'.

  AIDS (London, England) 20070330

• Impact of modelling intra-subject variability on tests based on non-linear mixed-effects models in cross-over pharmacokinetic trials with application to the interaction of tenofovir on atazanavir in HIV patients.

  Statistics in medicine 20070315

• Treatment of hepatitis B with lamivudine and tenofovir in HIV/HBV-coinfected patients: factors associated with response.

  Journal of viral hepatitis 20070301

• Antiviral therapy for pre- and post-liver transplantation patients with hepatitis B.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301

• Treatment of patients with lamivudine-resistant and adefovir dipivoxil-resistant chronic hepatitis B virus infection: is tenofovir the answer?

  Gut 20070301

• Tenofovir-induced kidney injury.

  Expert opinion on drug safety 20070301

• Treatment of chronic hepatitis B in HIV-infected patients in 2007.

  Journal of HIV therapy 20070301

• Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients.

  European journal of medical research 20070226

• Prevention. Anti-HIV drug could prevent transmission in women.

  AIDS policy & law 20070223

• Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.

  Molecular pharmacology 20070201

• Efficacy and safety of tenofovir double-dose in treatment-experienced HIV-infected patients: the TENOPLUS study.

  Journal of medical virology 20070201

• Visual loss secondary to acquired immunodeficiency virus-related progressive multifocal leukoencephalopathy demonstrating clinical improvement with highly active antiretroviral therapy.

  Optometry (St. Louis, Mo.) 20070201

• Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all?

  Expert opinion on pharmacotherapy 20070201

• Progressive multifocal leukoencephalopathy: serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy.

  AJNR. American journal of neuroradiology 20070201

• Renal safety of tenofovir disoproxil fumarate.

  The AIDS reader 20070201

• Editorial comment: tenofovir-related nephrotoxicity--who's at risk?

  The AIDS reader 20070201

• Induction therapy with enfuvirtide-based highly active antiretroviral therapy in a patient with acute HIV-1 infection.

  AIDS patient care and STDs 20070201

• Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy.

  Journal of medical primatology 20070201

• K65R development among subtype C HIV-1-infected patients in tenofovir DF clinical trials.

  AIDS (London, England) 20070111

• Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.

  The Journal of antimicrobial chemotherapy 20070101

• Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.

  Retrovirology 20070101

• Treatment of HIV/HBV coinfection: clinical and virologic issues.

  AIDS reviews 20070101

• Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors.

  Antiviral therapy 20070101

• Reversibility of cirrhosis in HIV/HBV coinfection.

  Antiviral therapy 20070101

• Renal function in antiretroviral-experienced patients treated with tenofovir disoproxil fumarate associated with atazanavir/ritonavir.

  Antiviral therapy 20070101

• Does tenofovir influence efavirenz pharmacokinetics?

  Antiviral therapy 20070101

• Improvements in parameters of end-stage liver disease in patients with HIV/HBV-related cirrhosis treated with tenofovir.

  Antiviral therapy 20070101

• Development of a sensitive and specific liquid chromatography/mass spectrometry method for the determination of tenofovir in human plasma.

  Rapid communications in mass spectrometry : RCM 20070101

• In vitro selection and characterization of human immunodeficiency virus type 1 resistant to Zidovudine and tenofovir.

  Nucleosides, nucleotides & nucleic acids 20070101

• Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenz.

  Antiviral therapy 20070101

• The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients.

  Antiviral therapy 20070101

• The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through 6 years in antiretroviral-naïve HIV-1-infected patients.

  HIV clinical trials 20070101

• Safety and tolerability of sequential pegylated IFN-alpha2a and tenofovir for hepatitis B infection in HIV(+) individuals.

  HIV clinical trials 20070101

• Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up.

  HIV clinical trials 20070101

• Renal safety of tenofovir in HIV-infected children: a prospective, 96-week longitudinal study.

  Clinical drug investigation 20070101

• Early onset of tenofovir-induced renal failure: case report and review of the literature.

  TheScientificWorldJournal 20070101

• Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV.

  Antiviral therapy 20070101

• A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.

  Antiviral therapy 20070101

• Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination with efavirenz: results of a systematic overview.

  HIV clinical trials 20070101

• Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.

  Antiviral chemistry & chemotherapy 20070101

• CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapy.

  Antiviral therapy 20070101

• Randomized controlled trial of once-daily tenofovir, lamivudine, and lopinavir/ritonavir versus remaining on the same regimen in virologically suppressed HIV-infected patients on their first PI-containing HAART regimen.

  HIV clinical trials 20070101

• Effectiveness and safety of simplification therapy with once-daily tenofovir, lamivudine, and efavirenz in HIV-1-infected patients with undetectable plasma viral load on HAART.

  HIV clinical trials 20070101

• Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors.

  Antiviral therapy 20070101

• The safety and efficacy of switching stavudine to tenofovir df in combination with lamivudine and efavirenz in hiv-1-infected patients: three-year follow-up after switching therapy.

  HIV clinical trials 20070101

• [Analysis of the causes and predictive factors for discontinuing treatment with tenofovir in pretreated HIV patients].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

• Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir.

  Nucleosides, nucleotides & nucleic acids 20070101

• Acute renal failure after initiation of tenofovir disoproxil fumarate.

  Renal failure 20070101

• Predicting tenofovir concentration on the basis of renal factors determined by routine tests.

  American journal of therapeutics 20070101

• Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study.

  Antiviral therapy 20070101

• Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis.

  Journal of acquired immune deficiency syndromes (1999) 20061215

• Virologic response of zidovudine, lamivudine, and tenofovir disoproxil fumarate combination in antiretroviral-naive HIV-1-infected patients.

  Journal of acquired immune deficiency syndromes (1999) 20061215

• Renal function in patients receiving tenofovir with ritonavir/lopinavir or ritonavir/atazanavir in the HIV Outpatient Study (HOPS) cohort.

  Journal of acquired immune deficiency syndromes (1999) 20061215

• In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.

  Antimicrobial agents and chemotherapy 20061201

• Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity.

  The Journal of infectious diseases 20061201

• Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

  The Journal of infectious diseases 20061201

• Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen.

  European journal of gastroenterology & hepatology 20061201

• Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.

  Neuro endocrinology letters 20061201

• Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.

  Xenobiotica; the fate of foreign compounds in biological systems 20061201

• Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugs.

  AIDS patient care and STDs 20061201

• Atripla approval in Europe.

  AIDS patient care and STDs 20061201

• Rate of virologic failure and selection of drug resistance mutations using different triple nucleos(t)ide analogue combinations in HIV-infected patients.

  AIDS research and human retroviruses 20061201

• Five-year data out on Viread.

  AIDS patient care and STDs 20061201

• Hepatitis B virus treatment in HIV-infected patients.

  Topics in HIV medicine : a publication of the International AIDS Society, USA 20061201

• [Use study of tenofovir DF in highly active anti-retroviral therapy].

  Anales de medicina interna (Madrid, Spain : 1984) 20061201

• A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.

  AIDS (London, England) 20061114

• Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107

• In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

  Antimicrobial agents and chemotherapy 20061101

• Acquired Fanconi's syndrome associated with tenofovir therapy.

  Journal of general internal medicine 20061101

• Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127.

  Hepatology (Baltimore, Md.) 20061101

• Evolving simplified treatment strategies for HIV infection: the role of a single-class quadruple-nucleoside/nucleotide regimen of trizivir and tenofovir.

  Expert opinion on pharmacotherapy 20061101

• Pharmacokinetics and safety of tenofovir disoproxil fumarate on coadministration with lopinavir/ritonavir.

  Journal of acquired immune deficiency syndromes (1999) 20061101

• HIV prophylaxis still has no clear cut answer.

  AIDS alert 20061101

• Report from the XVI International AIDS Conference. Preexposure prophylaxis studies move forward.

  AIDS clinical care 20061101

• A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy.

  AIDS (London, England) 20061024

• Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate.

  Virology 20061010

• Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection.

  AIDS (London, England) 20061003

• The role of tenofovir in the prevention of HIV infections.

  AIDS (London, England) 20061003

• Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903.

  HIV medicine 20061001

• Evaluation of hypophosphataemia in tenofovir disoproxil fumarate (TDF)-exposed and TDF-unexposed HIV-infected out-patients receiving highly active antiretroviral therapy.

  HIV medicine 20061001

• Estimating renal function in patients on tenofovir disoproxil fumarate: suggestions for safer use.

  HIV medicine 20061001

• Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061001

• Chemoprophylaxis of HIV infection: moving forward with caution.

  The Journal of infectious diseases 20061001

• Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges.

  The Journal of infectious diseases 20061001

• [Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients].

  Gastroenterologie clinique et biologique 20061001

• A once-daily combination tablet (Atripla) for HIV.

  The Medical letter on drugs and therapeutics 20060925

• Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.

  Journal of acquired immune deficiency syndromes (1999) 20060901

• Perspectives on the development of acyclic nucleotide analogs as antiviral drugs.

  Antiviral research 20060901

• Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children.

  Pediatrics 20060901

• Change to a once-daily combination including boosted atazanavir in HIV-1-infected children.

  The Pediatric infectious disease journal 20060901

• Hepatitis delta virus super-infection in a co-infected patient with the human immunodeficiency virus type 1 and a surface antigen-negative hepatitis B virus variant.

  International journal of STD & AIDS 20060901

• Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjögren-associated myelopathy.

  Archives of neurology 20060901

• Long-term follow-up of patients with initial early virologic failure after being treated with once-daily tenofovir/abacavir/lamivudine.

  AIDS patient care and STDs 20060901

• Virological outcome of chronic hepatitis B virus infection in HIV-coinfected patients receiving anti-HBV active antiretroviral therapy.

  AIDS research and human retroviruses 20060901

• A rapid and sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase.

  AIDS research and human retroviruses 20060901

• One pill, once daily: now an option for HIV patients.

  AIDS clinical care 20060901

• Once-daily dosing and the treatment of HIV disease.

  The AIDS reader 20060901

• Pre-exposure prophylaxis effective.

  AIDS patient care and STDs 20060901

• [Renal toxicity in HIV-infected patients receiving HAART including tenofovir].

  Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20060901

• Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases.

  AIDS (London, England) 20060822

• An update and review of antiretroviral therapy.

  Pharmacotherapy 20060801

• Hypokalemia in HIV patients on tenofovir.

  AIDS (London, England) 20060801

• Tenofovir disoproxil fumarate: role in hepatitis B treatment.

  Hepatology (Baltimore, Md.) 20060801

• Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.

  Hepatology (Baltimore, Md.) 20060801

• Rapid improvement of liver function in a patient with HIV and hepatitis B coinfection treated with lamivudine and tenofovir.

  Infection 20060801

• Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate.

  AIDS research and human retroviruses 20060801

• Tenofovir disoproxil fumarate-emtricitabine coformulation for once-daily dual NRTI backbone.

  Expert review of anti-infective therapy 20060801

• [Advances in the study of nucleoside antiviral drugs].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060801

• Comment on: suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir.

  The Journal of antimicrobial chemotherapy 20060701

• Renal safety of tenofovir disoproxil fumarate in HIV-1 treatment-experienced patients with adverse events related to prior NRTI use: data from a prospective, observational, multicenter study.

  Journal of acquired immune deficiency syndromes (1999) 20060701

• Virologic and immunologic efficacy of the tenofovir/didanosine/lamivudine regimen.

  Journal of acquired immune deficiency syndromes (1999) 20060701

• Influence of tenofovir, nevirapine and efavirenz on ritonavir-boosted atazanavir pharmacokinetics in HIV-infected patients.

  European journal of clinical pharmacology 20060701

• Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.

  Pediatric nephrology (Berlin, Germany) 20060701

• Moving toward assured access to treatment in microbicide trials. Global Campaign for Microbicides.

  PLoS medicine 20060701

• Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa.

  AIDS (London, England) 20060626

• Sustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with tenofovir.

  AIDS (London, England) 20060626

• Investigating new antiretroviral combinations.

  The Journal of infectious diseases 20060615

• HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

  AIDS (London, England) 20060612

• Tenofovir DF and emtricitabine vs. zidovudine and lamivudine.

  The New England journal of medicine 20060608

• Tenofovir DF and emtricitabine vs. zidovudine and lamivudine.

  The New England journal of medicine 20060608

• HIV-associated nephropathy and drug-induced renal injury.

  MedGenMed : Medscape general medicine 20060608

• Virological response to HIV-1 nucleoside/nucleotide reverse transcriptase inhibitors-based, tenofovir DF-including regimens in the ANRS Aquitaine Cohort.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060601

• Tenofovir-associated kidney diseases and interactions between tenofovir and other antiretrovirals.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060601

• The role of drug interactions and monitoring in the prevention of tenofovir-associated kidney disease.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060601

• FDA notifications. Two tenofovir containing products are approved.

  AIDS alert 20060601

• Tenofovir disoproxil fumarate for the treatment of HIV infection.

  Expert opinion on drug metabolism & toxicology 20060601

• AIDS drug trial turned away; protests by prostitutes in Cambodia ended Tenofovir testing.

  The Washington post 20060523

• Indian pressure group challenges company's right to patent AIDS drug.

  BMJ (Clinical research ed.) 20060520

• Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremia.

  AIDS (London, England) 20060512

• Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in HIV-positive adults?

  The Journal of infection 20060501

• Wild type and YMDD variant of hepatitis B virus: no difference in viral kinetics on lamivudine/tenofovir therapy in HIV-HBV co-infected patients.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060501

• Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir.

  The Journal of antimicrobial chemotherapy 20060501

• Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir.

  Journal of medical virology 20060501

• Improvement of dyslipidemia during different HAART regimens: tenofovir- versus stavudine-containing antiretroviral combinations.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060501

• Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects.

  Journal of clinical pharmacology 20060501

• Truvada trials hold promise for new HIV prevention strategy. Once-a-day might keep HIV away.

  AIDS alert 20060501

• FDA makes final approvals.

  AIDS patient care and STDs 20060501

• Workshop explores racial PK differences, TDF-PI interaction.

  IAPAC monthly 20060501

• Variant of hepatitis B virus with primary resistance to adefovir.

  The New England journal of medicine 20060427

• DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued.

  Virology 20060425

• Tenofovir-induced renal tubular dysfunction presenting with hypocalcaemia.

  The Journal of infection 20060401

• Use of tenofovir disoproxil fumarate and emtricitabine combination in HIV-infected patients.

  Expert opinion on pharmacotherapy 20060401

• Personal view: the management of chronic hepatitis B infection.

  Alimentary pharmacology & therapeutics 20060401

• Tenofovir for chronic hepatitis B virus infection in HIV-coinfected patients.

  The AIDS reader 20060401

• Short-term safety and tolerability of didanosine combined with high- versus low-dose tenofovir disproxil fumarate in ambulatory HIV-1-infected persons.

  AIDS patient care and STDs 20060401

• Higher risk of hyperglycemia in HIV-infected patients treated with didanosine plus tenofovir.

  AIDS research and human retroviruses 20060401

• Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cells.

  Stem cells and development 20060401

• Report from the 13th retrovirus conference. Renal tenofovir debate continues.

  AIDS clinical care 20060401

• 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures.

  AIDS (London, England) 20060321

• Serum creatinine changes in HIV-seropositive patients receiving tenofovir.

  AIDS (London, England) 20060321

• Registration problems for antiretrovirals in Africa.

  Lancet (London, England) 20060311

• Minor changes in calculated creatinine clearance and anion-gap are associated with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy.

  HIV medicine 20060301

• Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients.

  Hepatology (Baltimore, Md.) 20060301

• Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.

  AIDS (London, England) 20060227

• Retrovirus meeting. Novel attacks on HIV move closer to reality.

  Science (New York, N.Y.) 20060217

• Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.

  The Journal of infection 20060201

• Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication.

  Scandinavian journal of gastroenterology 20060201

• [Liver transplantation for complications of hepatitis B].

  Presse medicale (Paris, France : 1983) 20060201

• Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.

  The New England journal of medicine 20060119

• Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060115

• Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

• Improved lipid profiles and maintenance of virologic control in heavily pretreated HIV-infected patients who switched from stavudine to tenofovir treatment.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060101

• Assessment of drug-drug interactions between tenofovir disoproxil fumarate and the nonnucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients.

  Journal of acquired immune deficiency syndromes (1999) 20060101

• Case study: an active, 24-year-old woman positive for HIV.

  JAAPA : official journal of the American Academy of Physician Assistants 20060101

• Longitudinal study on mitochondrial effects of didanosine-tenofovir combination.

  AIDS research and human retroviruses 20060101

• Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients.

  Antiviral therapy 20060101

• An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy.

  Antiviral therapy 20060101

• Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy.

  Antiviral therapy 20060101

• Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues.

  Annals of clinical microbiology and antimicrobials 20060101

• Clinically stable treatment-experienced adults receiving tenofovir and didanosine.

  HIV clinical trials 20060101

• Salvage therapy with atazanavir/ritonavir combined to tenofovir in HIV-infected patients with multiple treatment failures: randomized ANRS 107 trial.

  Antiviral therapy 20060101

• Antiviral efficacy and genotypic resistance patterns of combination therapy with stavudine/tenofovir in highly active antiretroviral therapy experienced patients.

  Antiviral therapy 20060101

• Neuropsychiatric adverse events after switching from an antiretroviral regimen containing efavirenz without tenofovir to an efavirenz regimen containing tenofovir: a report of nine cases.

  Antiviral therapy 20060101

• In vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine.

  Antiviral therapy 20060101

• [Role of bone gammagraphy in the diagnosis of secondary osteomalacia in a patient treated with tenofovir].

  Revista espanola de medicina nuclear 20060101

• Tenofovir-containing nucleoside/nucleotide-only antiretroviral maintenance therapy: decision making and virological outcome.

  HIV clinical trials 20060101

• Serious renal impairment occurs rarely with use of tenofovir DF.

  HIV clinical trials 20060101

• Brazil: Gilead cuts tenofovir price in half.

  AIDS treatment news 20060101

• Efavirenz/emtricitabine/tenofovir disoproxil fumarate: triple combination tablet.

  Drugs 20060101

• [Immunological effectiveness of the nucleoside/nucleotide analog combinations, tenofovir + lamivudine, didanosine + lamivudine and tenofovir + didanosine, in patients with HIV infection and sustained viral suppression].

  Enfermedades infecciosas y microbiologia clinica 20060101

• Short communication metabolic and mitochondrial effects of switching antiretroviral-experienced patients to enfuvirtide, tenofovir and saquinavir/ritonavir.

  Antiviral therapy 20060101

• Pharmacokinetics and dosing recommendations of tenofovir disoproxil fumarate in hepatic or renal impairment.

  Clinical pharmacokinetics 20060101

• Tenofovir plus didanosine as Nrti backbone in HIV-infected subjects.

  Current medicinal chemistry 20060101

• [Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20060101

• [The Tenovofir trial in Cameroun. Analysis of the controversial positions and proposal for an ethical alternative].

  Sante (Montrouge, France) 20060101

• Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques.

  Retrovirology 20060101

• Anti-HIV agents. Merck integrase inhibitor.

  TreatmentUpdate 20060101

• Once-daily abacavir/lamivudine/zidovudine plus tenofovir for the treatment of HIV-1 infection in antiretroviral-naïve subjects: a 48-week pilot study.

  HIV clinical trials 20060101

• Drug interactions. Super pills-the treatments of the future?

  TreatmentUpdate 20060101

• Drug interactions. Brecanavir--a new protease inhibitor.

  TreatmentUpdate 20060101

• Report from the 2nd International Workshop on HIV and Hepatitis Co-Infection, January 12-14, 2006, Amsterdam, Netherlands. Tenofovir or adefovir for hepatitis B.

  TreatmentUpdate 20060101

• Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK.

  Antiviral therapy 20060101

• Antiretroviral efficacy and virological profile of a zidovudine/lamivudine/tenofovir disoproxil fumarate combination therapy in antiretroviral-naive patients.

  Antiviral therapy 20060101

• First of a kind in HIV treatment.

  FDA consumer 20060101

• Less than the sum of its parts: failure of a tenofovir-abacavir-Lamivudine triple-nucleoside regimen.

  The Journal of infectious diseases 20051201

• Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects.

  The Journal of infectious diseases 20051201

• Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virus.

  The Journal of antimicrobial chemotherapy 20051201

• Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro.

  Antiviral research 20051201

• A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children.

  Journal of acquired immune deficiency syndromes (1999) 20051201

• Drug-drug and drug-food interactions between tenofovir disoproxil fumarate and didanosine.

  Journal of clinical pharmacology 20051201

• Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection.

  Pediatrics 20051201

• Should tenofovir ever be used in association with didanosine?

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20051201

• [The treatment of HIV infection].

  Presse medicale (Paris, France : 1983) 20051119

• Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir.

  AIDS (London, England) 20051118

• Renal tubular toxicity associated with tenofovir assessed using urine-beta 2 microglobulin, percentage of tubular reabsorption of phosphate and alkaline phosphatase levels.

  AIDS (London, England) 20051118

• High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir.

  AIDS (London, England) 20051014

• Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have a comparable effect on the CD4 cell change after switching to tenofovir-based regimens.

  AIDS (London, England) 20051014

• Absence of new thymidine-associated mutations and evidence of an immune virologic response over a 12-month period in a cohort of antiretroviral-experienced HIV-1-infected subjects treated with tenofovir combination therapy.

  Journal of acquired immune deficiency syndromes (1999) 20051001

• The tenofovir pre-exposure prophylaxis trial in Thailand: researchers should show more openness in their engagement with the community.

  PLoS medicine 20051001

• Response to Joep M. A. Lange.

  PLoS medicine 20051001

• HIV prevention research in a resource-limited setting: the experience of planning a trial in Cambodia.

  Lancet (London, England) 20051001

• HIV Pathogenesis and Treatment - Third International AIDS Society Conference.

  IDrugs : the investigational drugs journal 20051001

• Hopes dashed for formulation.

  AIDS patient care and STDs 20051001

• AIDS. Promote HIV chemoprophylaxis research, don't prevent it.

  Science (New York, N.Y.) 20050930

• Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050915

• We must not let protestors derail trials of pre-exposure prophylaxis for HIV.

  PLoS medicine 20050901

• The abandoned trials of pre-exposure prophylaxis for HIV: what went wrong?

  PLoS medicine 20050901

• The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy.

  HIV medicine 20050901

• Severe toxicity associated with the combination of tenofovir and didanosine: case report and review.

  International journal of STD & AIDS 20050901

• Tenofovir and changes in renal function.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

• Lack of antagonism between abacavir, lamivudine, and tenofovir against wild-type and drug-resistant HIV-1.

  Journal of acquired immune deficiency syndromes (1999) 20050815

• Progression of renal impairment under therapy with tenofovir.

  AIDS (London, England) 20050812

• HIV/AIDS. Prevention cocktails: combining tools to Stop HIV's spread.

  Science (New York, N.Y.) 20050812

• Simultaneous quantification of emtricitabine and tenofovir in human plasma using high-performance liquid chromatography after solid phase extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

• Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).

  The Journal of pharmacology and experimental therapeutics 20050801

• Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens.

  Journal of acquired immune deficiency syndromes (1999) 20050801

• Systemic and renal pharmacokinetics of adefovir and tenofovir upon coadministration.

  Journal of clinical pharmacology 20050801

• Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment--case report and review of literature.

  The Journal of infection 20050801

• Tenofovir and didanosine: a dangerous liaison.

  The AIDS reader 20050801

• Protests may slow down trials.

  AIDS patient care and STDs 20050801

• Tenofovir trials raise ethical issues.

  HIV/AIDS policy & law review 20050801

• Early virologic failure in HIV-1 infected subjects on didanosine/tenofovir/efavirenz: 12-week results from a randomized trial.

  AIDS (London, England) 20050722

• Resistance mutations before and after tenofovir regimen failure in HIV-1 infected patients.

  Journal of medical virology 20050701

• Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol.

  The Journal of antimicrobial chemotherapy 20050701

• Fatal lactic acidosis associated with tenofovir and abacavir.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20050701

• Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results.

  Transplant international : official journal of the European Society for Organ Transplantation 20050701

• Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-containing highly active antiretroviral therapy regimen.

  AIDS (London, England) 20050701

• Reactivation of viral replication after replacement of tenofovir by adefovir.

  Hepatology (Baltimore, Md.) 20050701

• Viral dynamics during tenofovir therapy in patients infected with lamivudine-resistant hepatitis B virus mutants.

  Journal of viral hepatitis 20050701

• Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study.

  HIV medicine 20050701

• Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literature.

  The AIDS reader 20050701

• Editorial comment: tenofovir nephrotoxicity--vigilance required.

  The AIDS reader 20050701

• Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control study.

  AIDS patient care and STDs 20050701

• Long-term hepatitis B virus dynamics in HIV-hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate.

  AIDS (London, England) 20050610

• SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy.

  Journal of medical primatology 20050601

• [Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with Tenofovir].

  La Revue de medecine interne 20050601

• Stakeholder consultation to address issues related to tenofovir prophylactic research.

  IAPAC monthly 20050601

• Switching from protease inhibitors to a single-class regimen of abacavir/lamivudine/zidovudine plus tenofovir in patients with HIV load suppression.

  AIDS (London, England) 20050520

• Tenofovir in chronic hepatitis B.

  Hepatology (Baltimore, Md.) 20050501

• Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.

  Antimicrobial agents and chemotherapy 20050501

• The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily.

  HIV medicine 20050501

• The use of a triple nucleoside-nucleotide regimen for nonoccupational HIV post-exposure prophylaxis.

  HIV medicine 20050501

• Unethical clinical trials in Thailand: a community response.

  Lancet (London, England) 20050501

• Unethical clinical trials in Thailand: a community response.

  Lancet (London, England) 20050501

• Tenofovir helpful for patients with HBV.

  AIDS patient care and STDs 20050501

• Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures.

  AIDS (London, England) 20050429

• High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.

  AIDS (London, England) 20050429

• [Simply convincing. New fixed combination for HIV therapy].

  MMW Fortschritte der Medizin 20050425

• Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415

• Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active-controlled multicentre study.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050401

• Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine.

  The Journal of infectious diseases 20050401

• The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy.

  Journal of neurovirology 20050401

• Paradoxical CD4+ T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosine.

  AIDS (London, England) 20050324

• AIDS clinical trials. More woes for novel HIV prevention approach.

  Science (New York, N.Y.) 20050318

• Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050301

• Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice.

  Journal of acquired immune deficiency syndromes (1999) 20050301

• Adverse effects of antiretroviral therapy for HIV infection: a review of selected topics.

  Expert opinion on drug safety 20050301

• Early virologic failure in a pilot study evaluating the efficacy of therapy containing once-daily abacavir, lamivudine, and tenofovir DF in treatment-naive HIV-infected patients.

  AIDS patient care and STDs 20050301

• The trials of tenofovir trials.

  Lancet (London, England) 20050301

• Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel.

  AIDS (London, England) 20050218

• Tenofovir-induced acute renal failure in an HIV patient with normal renal function.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050201

• Tenofovir: a pill to prevent HIV?

  The Lancet. Infectious diseases 20050201

• Women testing tenofovir for HIV prevention.

  AIDS patient care and STDs 20050201

• Collaboration begins on combined drug.

  AIDS patient care and STDs 20050201

• Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine.

  AIDS (London, England) 20050128

• Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.

  AIDS (London, England) 20050103

• Low rate of treatment failure on antiretroviral therapy with tenofovir, lamivudine and zidovudine.

  AIDS (London, England) 20050103

• Pharmacokinetics of saquinavir hard gel/ritonavir (1000/100 mg twice daily) when administered with tenofovir diproxil fumarate in HIV-1-infected subjects.

  British journal of clinical pharmacology 20050101

• Prevalence and conditions of selection of the K65R mutation in the reverse transcriptase gene of HIV-1.

  Journal of acquired immune deficiency syndromes (1999) 20050101

• The experts speak. Studying the potential of tenofovir to prevent sexual transmission of HIV: first steps. Interview by Vicki Glaser.

  AIDS patient care and STDs 20050101

• Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection.

  Drugs 20050101

• Tenofovir regimen compared with Combivir.

  AIDS patient care and STDs 20050101

• Meeting notes from ICAAC. Tenofovir + ddI: a combination to avoid.

  AIDS clinical care 20050101

• Meeting notes from ICAAC. Tenofovir + emtricitabine vs. AZT + 3TC.

  AIDS clinical care 20050101

• Early virological failure with a combination of tenofovir, didanosine and efavirenz.

  Antiviral therapy 20050101

• [Cost-effectiveness analysis of tenofovir versus zidovudine in combination therapy with efavirenz and lamivudine for the treatment of HIV in naive patients].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

• In vitro combination studies of tenofovir and other nucleoside analogues with ribavirin against HIV-1.

  Antiviral therapy 20050101

• The steady-state pharmacokinetics of nelfinavir in combination with tenofovir in HIV-infected patients.

  Antiviral therapy 20050101

• Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine.

  Antiviral therapy 20050101

• [Assessment of renal abnormalities in 107 HIV patients treated with tenofovir].

  Therapie 20050101

• Drugs in development for hepatitis B.

  Drugs 20050101

• Selected rare, noninfectious syndromes associated with HIV infection.

  Topics in HIV medicine : a publication of the International AIDS Society, USA 20050101

• Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir.

  Clinical pharmacokinetics 20050101

• Treatment news. What's 'The T'?

  Survival news (Atlanta, Ga.) 20050101

• Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.

  Antiviral therapy 20050101

• Hepatic and renal safety profile of tenofovir in HIV-infected patients with hepatitis C, including patients on interferon plus ribavirin.

  HIV clinical trials 20050101

• Simplification therapy with once-daily didanosine, tenofovir and efavirenz in HIV-1-infected adults with viral suppression receiving a more complex antiretroviral regimen: final results of the EFADITE trial.

  Antiviral therapy 20050101

• Failure of tenofovir + abacavir + 3TC combination; full report published, more insight.

  AIDS treatment news 20050101

• Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children.

  Antiviral therapy 20050101

• Anti-HIV agents. Dueling nukes: AZT + 3TC vs. tenofovir + FTC.

  TreatmentUpdate 20050101

• CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related.

  AIDS (London, England) 20041203

• Tenofovir therapy for lamivudine resistance following liver transplantation.

  The Annals of pharmacotherapy 20041201

• Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection.

  Hepatology (Baltimore, Md.) 20041201

• New once-daily HIV combination better tolerated.

  Expert review of anti-infective therapy 20041201

• Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently: a cohort and case-control study.

  Journal of acquired immune deficiency syndromes (1999) 20041201

• Saquinavir trough concentration before and after switching NRTI to tenofovir in patients treated with once-daily saquinavir hard gel capsule/ritonavir 1600 mg/100 mg.

  Antiviral therapy 20041201

• Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.

  AIDS (London, England) 20041119

• The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro.

  AIDS (London, England) 20041105

• Impact of a treatment including tenofovir plus didanosine on the selection of the 65R mutation in highly drug-experienced HIV-infected patients.

  AIDS (London, England) 20041105

• Patterns of resistance emerging in HIV-1 from antiretroviral-experienced patients undergoing intensification therapy with tenofovir disoproxil fumarate.

  Journal of acquired immune deficiency syndromes (1999) 20041101

• Tenofovir use in a patient with a severe renal impairment.

  HIV medicine 20041101

• Warning on two specific 3-drug regimens: Viread + Didanosine + either Sustiva or Viramune.

  AIDS treatment news 20041029

• Tenofovir, equivalence, and noninferiority.

  JAMA 20041027

• Predictors of selection of K65R: tenofovir use and lack of thymidine analogue mutations.

  AIDS (London, England) 20041021

• Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.

  The Journal of infectious diseases 20041015

• Acute onset of pancreatitis with concomitant use of tenofovir and didanosine.

  The Annals of pharmacotherapy 20041001

• Correlation between rules-based interpretation and virtual phenotype interpretation of HIV-1 genotypes for predicting drug resistance in HIV-infected individuals.

  Journal of virological methods 20041001

• Trial of antiretroviral for HIV prevention on hold.

  The Lancet. Infectious diseases 20041001

• Ninety-six-week efficacy of combination therapy with lamivudine and tenofovir in patients coinfected with HIV-1 and wild-type hepatitis B virus.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041001

• Increasing prevalence of HIV-1 reverse transcriptase mutation K65R correlates with tenofovir utilization.

  Antiviral therapy 20041001

• 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.

  Nucleosides, nucleotides & nucleic acids 20041001

• Tenofovir and renal toxicity.

  AIDS patient care and STDs 20041001

• Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men.

  AIDS (London, England) 20040924

• Intracellular pharmacology of emtricitabine and tenofovir.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040915

• Lichenoid drug eruption to tenofovir in an HIV/hepatitis B virus co-infected patient.

  AIDS (London, England) 20040903

• Treatment of hepatitis B virus infection in patients coinfected with HIV.

  Gastroenterology clinics of North America 20040901

• Nephrolithiasis and hydronephrosis in an HIV-infected man receiving tenofovir.

  International journal of antimicrobial agents 20040901

• Box warning updated for tenofovir.

  AIDS patient care and STDs 20040901

• Management of HIV-infected patients with multidrug-resistant virus.

  Current HIV/AIDS reports 20040901

• Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.

  AIDS (London, England) 20040820

• Proximal tubular kidney damage and tenofovir: a role for mitochondrial toxicity?

  AIDS (London, England) 20040820

• AIDS research. Cambodian leader throws novel prevention trial into limbo.

  Science (New York, N.Y.) 20040820

• Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure.

  The American journal of medicine 20040815

• The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.

  Journal of acquired immune deficiency syndromes (1999) 20040801

• Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion.

  Antiviral research 20040801

• Effect of tenofovir disoproxil fumarate on the pharmacokinetics and pharmacodynamics of total, R-, and S-methadone.

  Pharmacotherapy 20040801

• Fatal lactic acidosis associated with coadministration of didanosine and tenofovir disoproxil fumarate.

  Pharmacotherapy 20040801

• Selection of K65R mutation in HIV-2-infected patients receiving tenofovir-containing regimen.

  Antiviral therapy 20040801

• Haemolytic anaemia after nucleotide antiretroviral treatment discontinuation in a chronic hepatitis B-virus co-infected AIDS patient.

  AIDS (London, England) 20040723

• Cambodia stops important tenofovir prevention trial.

  AIDS treatment news 20040723

• Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial.

  JAMA 20040714

• Improvement of dyslipidemia in patients switching from stavudine to tenofovir: preliminary results.

  AIDS (London, England) 20040702

• Virologic outcome after switching from a nucleoside reverse transcriptase inhibitor to tenofovir in patients with undetectable HIV-1 RNA plasma level.

  Journal of acquired immune deficiency syndromes (1999) 20040701

• Unexpected drug interactions and adverse events with antiretroviral drugs.

  Lancet (London, England) 20040701

• Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults.

  Lancet (London, England) 20040701

• Genotypic determinants of the virological response to tenofovir disoproxil fumarate in nucleoside reverse transcriptase inhibitor-experienced patients.

  Antiviral therapy 20040601

• Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach.

  Antiviral therapy 20040601

• In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir.

  Antiviral therapy 20040601

• Prevention trials starting.

  AIDS patient care and STDs 20040601

• [New approaches in the treatment of hepatitis B].

  Deutsche medizinische Wochenschrift (1946) 20040521

• Fanconi's syndrome in HIV+ adults: report of three cases and literature review.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040501

• Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.

  Nature structural & molecular biology 20040501

• The K65R mutation in HIV-1 reverse transcriptase.

  Journal of HIV therapy 20040501

• Renal safety of tenofovir in HIV treatment-experienced patients.

  AIDS (London, England) 20040430

• [3 years' data of tenofovir. Confirmed as a valuable building block].

  MMW Fortschritte der Medizin 20040426

• [5 years' data are convincing. Lopinavir as primary therapy is effective and safe in the long term].

  MMW Fortschritte der Medizin 20040426

• Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase.

  AIDS (London, England) 20040409

• Tenofovir-related nephrotoxicity in HIV-infected patients.

  AIDS (London, England) 20040409

• Efficacy of tenofovir disoproxil fumarate in antiretroviral therapy-naive and -experienced patients coinfected with HIV-1 and hepatitis B virus.

  The Journal of infectious diseases 20040401

• Didanosine-associated toxicity: a predictable complication of therapy with tenofovir and didanosine?

  Journal of acquired immune deficiency syndromes (1999) 20040401

• Atazanavir (Reyataz): new recommendations if combined with tenofovir (Viread) -- and warning on Viagra, Cialis, and Levitra.

  AIDS treatment news 20040326

• Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients.

  The Journal of infectious diseases 20040301

• Antiretroviral therapy and HIV/hepatitis B virus coinfection.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301

• Tenofovir disoproxil fumarate for the treatment of lamivudine-resistant hepatitis B.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040301

• Hepatitis B infection in an HIV-positive man treated with tenofovir: a case of re-infection or reactivation?

  International journal of STD & AIDS 20040301

• Tenofovir-related nephrotoxicity: case report and review of the literature.

  Pharmacotherapy 20040301

• Management of chronic hepatitis B in the HIV-infected patient.

  The AIDS reader 20040301

• Editorial comment: HIV and HBV coinfection--a coming-of-age in treatment strategies.

  The AIDS reader 20040301

• Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases.

  Journal of acquired immune deficiency syndromes (1999) 20040301

• Anti-HIV agents. Low rate of early virologic failure seen with a combination of Trizivir and tenofovir.

  TreatmentUpdate 20040301

• Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load.

  AIDS (London, England) 20040220

• Newer treatments for HIV in children.

  Current opinion in pediatrics 20040201

• Fanconi syndrome and acute renal failure in a patient treated with tenofovir: a call for caution.

  AIDS (London, England) 20040123

• Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay.

  Journal of theoretical biology 20040107

• Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations.

  The Journal of biological chemistry 20040102

• Tenofovir: a nucleotide analogue reverse-transcriptase inhibitor for treatment of HIV infection.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040101

• Can AIDS drug also prevent HIV infection?

  The AIDS reader 20040101

• Labeling changes for tenofovir.

  AIDS patient care and STDs 20040101

• EU issues warning about HAART regimen.

  AIDS patient care and STDs 20040101

• Emtricitabine/tenofovir disoproxil fumarate.

  Drugs in R&D 20040101

• K65R, TAMs and tenofovir.

  AIDS reviews 20040101

• New treatment of chronic hepatitis B.

  Seminars in liver disease 20040101

• Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.

  Current topics in medicinal chemistry 20040101

• Tenofovir treatment in an unselected cohort of highly antiretroviral experienced HIV positive patients.

  Scandinavian journal of infectious diseases 20040101

• Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics.

  Clinical pharmacokinetics 20040101

• K65R-associated virologic failure in HIV-infected patients receiving tenofovir-containing triple nucleoside/nucleotide reverse transcriptase inhibitor regimens.

  MedGenMed : Medscape general medicine 20040101

• Severe metabolic acidosis and renal failure in an HIV-1 patient receiving tenofovir.

  Scandinavian journal of infectious diseases 20040101

• Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1.

  Scandinavian journal of infectious diseases 20040101

• Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).

  Psychosomatics 20040101

• Strategies for overcoming resistance in HIV-1 infected patients receiving HAART.

  AIDS reviews 20040101

• Combinations of nucleoside/nucleotide analogues for HIV therapy.

  AIDS reviews 20040101

• Anti-HIV agents. The puzzle of virologic failure with tenofovir.

  TreatmentUpdate 20040101

• Anti-HIV agents. No interaction between tenofovir and saquinavir.

  TreatmentUpdate 20040101

• Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031215

• Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031215

• Change to abacavir-lamivudine-tenofovir combination treatment in patients with HIV-1 who had complete virological suppression.

  Lancet (London, England) 20031213

• The continuing evolution of HIV therapy.

  The AIDS reader 20031201

• French investigators warn of LPV/TDF/ddI interaction.

  IAPAC monthly 20031201

• Acute tubular necrosis in a patient receiving tenofovir.

  AIDS (London, England) 20031121

• Studies of molecular mechanism of tenofovir against 3TC- and AZT-resistance mutant HIV-1 reverse transcriptase.

  Bioorganic & medicinal chemistry letters 20031117

• Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.

  Toxicology and applied pharmacology 20031101

• Triple combinations regimens for HIV.

  The Lancet. Infectious diseases 20031101

• Meeting notes from the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Suboptimal response to once-daily abacavir + 3TC + tenofovir.

  AIDS clinical care 20031101

• Early nonresponse for tenofovir regimen.

  AIDS patient care and STDs 20031101

• High rate of virologic failure with once-daily ddI/3TC/TDF.

  IAPAC monthly 20031101

• Fanconi-like syndrome and rhabdomyolysis in a person with HIV infection on highly active antiretroviral treatment including tenofovir.

  The Journal of infection 20031001

• Tenofovir disoproxil fumarate.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031001

• Warning issued on non-response rates.

  AIDS patient care and STDs 20031001

• Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions.

  Antiviral research 20031001

• Tenofovir disoproxil fumarate (Viread) for the treatment of HIV infection.

  Expert review of anti-infective therapy 20031001

• Anti-HIV agents. Trying times for tenofovir and abacavir.

  TreatmentUpdate 20031001

• Drug points: Fatal lactic acidosis associated with tenofovir.

  BMJ (Clinical research ed.) 20030927

• [Further indications for tenofovir].

  Deutsche medizinische Wochenschrift (1946) 20030926

• Cambodia: can a drug provide some protection?

  Science (New York, N.Y.) 20030919

• Tenofovir disoproxil fumarate in nucleoside-resistant HIV-1 infection: a randomized trial.

  Annals of internal medicine 20030902

• Summaries for patients. Treatment for resistant HIV-1 infection.

  Annals of internal medicine 20030902

• Effect of tenofovir on didanosine absorption in patients with HIV.

  The Annals of pharmacotherapy 20030901

• Pharmacokinetics of tenofovir in haemodialysis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030901

• Pancreatitis with didanosine and tenofovir disoproxil fumarate [corrected].

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030901

• Tenofovir, COX inhibitors and zileuton during cancer immunotherapies: up-regulated TNF-alpha increases antigen driven lymphocyte proliferation.

  Molecular immunology 20030901

• GlaxoSmithKline halts AIDS study.

  The Lancet. Infectious diseases 20030901

• Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus.

  AIDS patient care and STDs 20030901

• Meeting notes from the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Exploring once-daily tenofovir + 3TC + abacavir: an argument for clinical-trials-based data.

  AIDS clinical care 20030901

• BMS issues PK notice regarding ATV + TDF.

  IAPAC monthly 20030901

• Sensitive determination of tenofovir in human plasma samples using reversed-phase liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030815

• Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines.

  European journal of pharmacology 20030815

• Pancreatitis in an HIV-infected person on a tenofovir, didanosine and stavudine containing highly active antiretroviral treatment.

  The Journal of infection 20030801

• Evolution of lipid abnormalities in patients switched from stavudine- to tenofovir-containing regimens.

  Journal of acquired immune deficiency syndromes (1999) 20030801

• Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors.

  The Journal of infectious diseases 20030801

• Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndrome.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030801

• Preemptive use of antiretroviral drugs to prevent sexual transmission of HIV to high-risk uninfected MSM.

  American journal of public health 20030801

• Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge.

  Journal of medical primatology 20030801

• Failure of combination abacavir + tenofovir + lamivudine (3TC).

  AIDS treatment news 20030725

• [HIV therapy: tenofir DF is available in 68 developing countries at production costs price].

  Medizinische Klinik (Munich, Germany : 1983) 20030715

• Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

• Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

  Antimicrobial agents and chemotherapy 20030701

• Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection.

  The Pediatric infectious disease journal 20030701

• The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).

  Antiviral research 20030701

• Tenofovir disoproxil fumarate.

  The Annals of pharmacotherapy 20030601

• Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.

  Pharmacotherapy 20030601

• Antiviral Research--16th Annual International Conference. Satellite symposium: clinical update on antiviral drugs. 27 April-1 May 2003, Savannah, GA, USA.

  IDrugs : the investigational drugs journal 20030601

• Tenofovir poses risk with didanosine.

  AIDS patient care and STDs 20030601

• Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections.

  Expert review of anti-infective therapy 20030601

• Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals.

  AIDS (London, England) 20030523

• [96-week treatment outcome confirms long term efficacy of tenofovir DF].

  Deutsche medizinische Wochenschrift (1946) 20030509

• Evaluation of mitochondrial DNA content and enzyme levels in tenofovir DF-treated rats, rhesus monkeys and woodchucks.

  Antiviral research 20030501

• Extended treatment with tenofovir disoproxil fumarate in treatment-experienced HIV-1-infected patients: genotypic, phenotypic, and rebound analyses.

  Journal of acquired immune deficiency syndromes (1999) 20030501

• [First nucleotide analog with noteworthy safety profile. Tenofovir effective in all stages of the infection].

  MMW Fortschritte der Medizin 20030428

• [Resistance in a new light. About mutations and their interactions].

  MMW Fortschritte der Medizin 20030428

• [Lipid profile and body fat--significant 'side effect' of antiretroviral therapy. Tenofovir: favorable profile of adverse effects].

  MMW Fortschritte der Medizin 20030428

• Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030415

• Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030415

• Renal lesions in HIV-1-positive patient treated with tenofovir.

  AIDS (London, England) 20030411

• Rapid hepatitis B virus-DNA decay in co-infected HIV-hepatitis B virus 'e-minus' patients with YMDD mutations after 4 weeks of tenofovir therapy.

  AIDS (London, England) 20030328

• Determining the relative efficacy of highly active antiretroviral therapy.

  The Journal of infectious diseases 20030315

• Determination of tenofovir in human plasma by high-performance liquid chromatography with spectrofluorimetric detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030305

• Tenofovir disoproxil fumarate exhibits strong antiviral effect in a patient with lamivudine-resistant severe hepatitis B reactivation.

  Gastroenterology 20030201

• The use of tenofovir disoproxil fumarate for the treatment of nucleoside-resistant HIV-1.

  The Journal of antimicrobial chemotherapy 20030201

• Thymidine analogue-sparing highly active antiretroviral therapy (HAART).

  Journal of HIV therapy 20030201

• Tenofovir disoproxil fumarate in patients with HIV and lamivudine-resistant hepatitis B virus.

  The New England journal of medicine 20030109

• An open-label study of tenofovir in HIV-1 and Hepatitis B virus co-infected individuals.

  AIDS (London, England) 20030103

• Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection.

  Pharmacotherapy 20030101

• Tenofovir helps beat hepatitis B.

  TreatmentUpdate 20030101

• New uses for tenofovir: more questions about d4T.

  Project Inform perspective 20030101

• Tenofovir--long term results from first-line therapy.

  TreatmentUpdate 20030101

• Kidney damage reported in some tenofovir users.

  TreatmentUpdate 20030101

• Tenofovir drug interactions: ddI and d4T.

  TreatmentUpdate 20030101

• HIV and hepatitis B virus: options for managing coinfection.

  Topics in HIV medicine : a publication of the International AIDS Society, USA 20030101

• HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).

  Antiviral chemistry & chemotherapy 20030101

• Correction: tenofovir disoproxil fumarate.

  The Annals of pharmacotherapy 20030101

• Tenofovir disoproxil fumarate.

  Drugs 20030101

• Tenofovir disoproxil fumarate.

  Drugs 20030101

• Tenofovir disoproxil fumarate.

  Drugs 20030101

• Viread, Epivir and Ziagen combination: failure in naïve patients with a once-daily regimen.

  Positively aware : the monthly journal of the Test Positive Aware Network 20030101

• Treatment of chronic hepatitis B virus infection in patients co-infected with human immunodeficiency virus.

  Journal of hepatology 20030101

• Report from the 4th International Workshop on Clinical Pharmacology of HIV Therapy. Checking up on ddI and tenofovir in people with HIV/AIDS.

  TreatmentUpdate 20030101

• Tenofovir (Viread(R)) access for poor countries.

  AIDS treatment news 20021220

• Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed.

  The Journal of infectious diseases 20021215

• Fanconi syndrome and renal failure induced by tenofovir: a first case report.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20021201

• Rapid communication: acute renal failure associated with tenofovir: evidence of drug-induced nephrotoxicity.

  The American journal of the medical sciences 20021201

• Activity of tenofovir on hepatitis B virus replication in HIV-co-infected patients failing or partially responding to lamivudine.

  AIDS (London, England) 20021122

• Prevention: new approach will test tenofovir for persons at high risk.

  AIDS treatment news 20021122

• Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus.

  The Journal of infectious diseases 20021115

• Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells.

  AIDS (London, England) 20021108

• Marked elevation of the creatine phosphokinase level in a patient receiving tenofovir.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101

• Inhibition of murine AIDS by a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphonomethoxypropyl)adenine.

  The Journal of antimicrobial chemotherapy 20021101

• Would switching the protease inhibitors (PI) to tenoforvir be an option in controlling hypertriglyceridaemia secondary to PIs? A case report.

  International journal of STD & AIDS 20021101

• Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta).

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20021101

• The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients.

  AIDS (London, England) 20021018

• Phenotypic and genotypic HIV-1 drug resistance assays provide complementary information.

  Journal of acquired immune deficiency syndromes (1999) 20021001

• Editorial comment: a tale of two viruses.

  The AIDS reader 20021001

• Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection.

  Clinical therapeutics 20021001

• [First nucleotide analog against HIV. Lowers viral load also in drug resistance].

  MMW Fortschritte der Medizin 20020822

• [Tenofovir in Study 903. Also effective and tolerable in first-line therapy].

  MMW Fortschritte der Medizin 20020822

• Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

  Drug metabolism and disposition: the biological fate of chemicals 20020801

• Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication.

  Hepatology (Baltimore, Md.) 20020801

• Tenofovir gel studied.

  AIDS patient care and STDs 20020801

• Anti-HIV agents. Tenofovir looks good in initial therapy.

  TreatmentUpdate 20020801

• Anti-HIV agents. Tenofovir and Videx (ddi) EC--some caution required.

  TreatmentUpdate 20020801

• ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase.

  Antimicrobial agents and chemotherapy 20020701

• Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.

  Antiviral research 20020701

• New drugs 2002, part III.

  Nursing 20020701

• Vaccines. Monkey puzzles.

  Science (New York, N.Y.) 20020628

• Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF.

  AIDS (London, England) 20020614

• Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study.

  AIDS (London, England) 20020614

• Drugs in development.

  AIDS patient care and STDs 20020501

• [Nucleotide analog shows effectiveness in previously treated patients. The new kind of HAART].

  MMW Fortschritte der Medizin 20020409

• [No comparison with NRTI. Tenofovir is robust against resistance trouble].

  MMW Fortschritte der Medizin 20020409

• [First nucleotide analog on the market. New drug for the pretreated patient].

  MMW Fortschritte der Medizin 20020409

• Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

  Antiviral research 20020401

• [Tenofovir--a new option for combination therapy].

  Medizinische Monatsschrift fur Pharmazeuten 20020401

• 8th European Conference on Clinical Aspects and Treatment of HIV Infection, Athens, 28-31 October 2001.

  Sexually transmitted infections 20020401

• Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors.

  Antimicrobial agents and chemotherapy 20020301

• Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta).

  Journal of acquired immune deficiency syndromes (1999) 20020301

• New antiretroviral for HIV infection.

  American family physician 20020301

• Tenofovir helps experienced patients.

  AIDS patient care and STDs 20020301

• Promising new agents on the horizon.

  AIDS clinical care 20020301

• Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status.

  Blood 20020115

• Prodrug of tenofovir diphosphate approved for combination HIV therapy.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020101

• Tenofovir (viread) receives FDA approval.

  AIDS alert 20020101

• Nutrient deficiency associated with new HIV medication.

  Survival news (Atlanta, Ga.) 20020101

• Gilead sciences releases Viread.

  Survival news (Atlanta, Ga.) 20020101

• FDA approves Viread for HIV-1 infection.

  FDA consumer 20020101

• FDA approves tenofovir.

  AIDS patient care and STDs 20020101

• Use of tenofovir.

  AIDS patient care and STDs 20020101

• Tenofovir disoproxil fumarate (Viread).

  The Journal of the Association of Nurses in AIDS Care : JANAC 20020101

• Highlights of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

  The Body positive 20020101

• [Tenofovir (Viread)].

  SIDAhora : un proyecto del Departamento de Publicaciones del PWA Coalition, NY 20020101

• From the Food and Drug Administration.

  JAMA 20011205

• Hydroxyurea does not enhance the anti-HIV activity of low-dose tenofovir disoproxil fumarate.

  Journal of acquired immune deficiency syndromes (1999) 20011201

• The potential place of tenofovir in antiretroviral treatment regimens.

  International journal of clinical practice 20011201

• Viread gets FDA nod.

  Positive living (Los Angeles, Calif.) 20011201

• Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs.

  Cancer research 20011101

• Tenofovir approved: broad indication.

  AIDS treatment news 20011026

• Tenofovir: FDA hearing on important new antiretroviral.

  AIDS treatment news 20011019

• Tenacious tenofovir struts its stuff in a virtual ICAAC.

  GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20011001

• Expanded access to tenofovir.

  TreatmentUpdate 20011001

• Tenofovir: FDA hearing October 3, public comment deadlines September 26.

  AIDS treatment news 20010824

• Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection.

  The Journal of infectious diseases 20010815

• Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408.

  Journal of acquired immune deficiency syndromes (1999) 20010815

• Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance.

  AIDS research and human retroviruses 20010810

• Tenofovir ready for approval.

  AIDS patient care and STDs 20010701

• Tenofovir: Gilead applies for approval; expanded access liberalized.

  AIDS treatment news 20010511

• Encouraging results for tenofovir.

  AIDS patient care and STDs 20010501

• Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

  Bioorganic & medicinal chemistry letters 20010423

• [Once daily administration improves therapy adherence in HAART. New substance class with more powerful reserves against virus resistance].

  MMW Fortschritte der Medizin 20010402

• Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?

  Current opinion in investigational drugs (London, England : 2000) 20010301

• New antiretroviral agents.

  The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20010301

• Tenofovir DF expanded access. Criteria for U.S. program.

  AIDS treatment news 20010223

• More uses for tenofovir?

  AIDS treatment news 20010125

• Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.

  Proceedings of the National Academy of Sciences of the United States of America 20010116

• Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.

  Virology 20010105

• Enhanced cellular immune response and reduced CD8(+) lymphocyte apoptosis in acutely SIV-infected Rhesus macaques after short-term antiretroviral treatment.

  Virology 20010105

• Antiviral activity of tenofovir (PMPA) against nucleoside-resistant clinical HIV samples.

  Nucleosides, nucleotides & nucleic acids 20010101

• Purification of PMPA amidate prodrugs by SMB chromatography and x-ray crystallography of the diastereomerically pure GS-7340.

  Nucleosides, nucleotides & nucleic acids 20010101

• Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.

  Nucleosides, nucleotides & nucleic acids 20010101

• Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution.

  Nucleosides, nucleotides & nucleic acids 20010101

• LC/MS determination of the intracellular concentration of two novel aryl phosphoramidate prodrugs of PMPA and their metabolites in dog PBMC.

  Nucleosides, nucleotides & nucleic acids 20010101

• Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes.

  Nucleosides, nucleotides & nucleic acids 20010101

• Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340.

  Nucleosides, nucleotides & nucleic acids 20010101

• Tenofovir (PMPA) is less susceptible to pyrophosphorolysis and nucleotide-dependent chain-terminator removal than zidovudine or stavudine.

  Nucleosides, nucleotides & nucleic acids 20010101

• The importance of sequencing in treatment options.

  Positively aware : the monthly journal of the Test Positive Aware Network 20010101

• Tenofovir DF on the horizon. Investigational nucleotide reverse transcriptor inhibitor could be on pharmacy shelves soon.

  Positive living (Los Angeles, Calif.) 20010101

• Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.

  Journal of viral hepatitis 20000101

• Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.

  The Journal of biological chemistry 19981016

• Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains.

  Antimicrobial agents and chemotherapy 19980601

• Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.

  Antimicrobial agents and chemotherapy 19980301

• Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses.

  Antiviral research 19971101

• Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.

  Antimicrobial agents and chemotherapy 19970301

• Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.

  Science (New York, N.Y.) 19951117