206645-99-0 | Compstatin

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$30.00	$21.00
5mg	99%	in stock	$68.00	$48.00

Description

• Catalog Number: AF61525
• Chemical Name: Compstatin
• CAS Number: 206645-99-0
• Molecular Formula: C66H99N23O17S2
• Molecular Weight: 1550.7662
• MDL Number: MFCD09263618
• SMILES: CC[C@@H]([C@@H](C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2nc[nH]c2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)CCC(=O)N)CC(=O)O)Cc1c[nH]c2c1cccc2)Cc1nc[nH]c1)C(=O)N[C@H](C(=O)N)[C@H](O)C)N)C

Computed Properties

• Complexity: 3180
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 14
• Heavy Atom Count: 108
• Hydrogen Bond Acceptor Count: 23
• Hydrogen Bond Donor Count: 22
• Rotatable Bond Count: 25
• XLogP3: -6.7

Literature

• Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention.

  Molecular oral microbiology 20160201

• Complement, a target for therapy in inflammatory and degenerative diseases.

  Nature reviews. Drug discovery 20151201

• Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy.

  Immunobiology 20150801

• Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.

  European journal of clinical investigation 20150401

• A new generation of potent complement inhibitors of the Compstatin family.

  Chemical biology & drug design 20110601

• Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration.

  Advances in experimental medicine and biology 20100101

• Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects.

  Journal of immunology (Baltimore, Md. : 1950) 20091115

• Structure-activity relationships for substrate-based inhibitors of human complement factor B.

  Journal of medicinal chemistry 20091008

• Complement activation by bisretinoid constituents of RPE lipofuscin.

  Investigative ophthalmology & visual science 20090301

• Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin.

  Journal of molecular recognition : JMR 20090101

• Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation.

  Transplantation 20080427

• Small-molecule complement inhibitors cannot prevent the development of the platelet storage lesion.

  Transfusion 20080401

• Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.

  Bioorganic & medicinal chemistry 20080215

• Compstatin: a complement inhibitor on its way to clinical application.

  Advances in experimental medicine and biology 20080101

• Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.

  Journal of medicinal chemistry 20060727

• Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity.

  Protein expression and purification 20060501

• Design and NMR characterization of active analogues of compstatin containing non-natural amino acids.

  Journal of medicinal chemistry 20050113

• Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin.

  The Journal of biological chemistry 20041231

• Synthetic small-molecule complement inhibitors.

  Current opinion in investigational drugs (London, England : 2000) 20041101

• Studies of structure-activity relations of complement inhibitor compstatin.

  Journal of immunology (Baltimore, Md. : 1950) 20030815

• Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin.

  Journal of immunology (Baltimore, Md. : 1950) 20000901

• Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.

  Journal of immunology (Baltimore, Md. : 1950) 19960715