20780-72-7 | 4-Bromoisatin

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$10.00	$7.00
25g	98%	in stock	$24.00	$17.00

Description

• Catalog Number: AB18124
• Chemical Name: 4-Bromoisatin
• CAS Number: 20780-72-7
• Molecular Formula: C8H4BrNO2
• Molecular Weight: 226.0269
• MDL Number: MFCD03618555
• SMILES: O=C1Nc2c(C1=O)c(Br)ccc2

Computed Properties

• Complexity: 241
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.4

Upstream Synthesis Route

4-Bromoisatin is a versatile and valuable compound used in various chemical synthesis processes. In organic chemistry, it serves as an important building block for the synthesis of various heterocyclic compounds and complex molecules. One significant application of 4-Bromoisatin is in the synthesis of indole derivatives. By utilizing 4-Bromoisatin as a key starting material, chemists can efficiently access a wide range of functionalized indole compounds with diverse structural motifs. This compound acts as a crucial intermediate in the construction of biologically active molecules, pharmaceuticals, and natural products.Furthermore, 4-Bromoisatin plays a vital role in transition-metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions. These reactions enable the incorporation of different functional groups onto the 4-Bromoisatin scaffold, facilitating the rapid generation of structurally complex molecules with desired properties.Additionally, 4-Bromoisatin is utilized in the synthesis of fluorescent dyes and materials due to its inherent fluorescence properties. By functionalizing the core structure of 4-Bromoisatin, researchers can tailor its photophysical properties for applications in materials science, bioimaging, and sensor development.Overall, the versatile nature of 4-Bromoisatin makes it a valuable tool in chemical synthesis, enabling the efficient construction of diverse molecular architectures with implications in drug discovery, materials science, and other areas of research.

Literature

• QSAR study of isatin analogues as in vitro anti-cancer agents.

  European journal of medicinal chemistry 20100301

• 2-Amino-4'-bromo-2',5-dioxo-4H,5H-pyrano[3,2-c]chromene-4-spiro-3'(2'H)-1'H-indole-3-carbonitrile N,N-dimethyl-formamide solvate.

  Acta crystallographica. Section E, Structure reports online 20080601

• Biological targets for isatin and its analogues: Implications for therapy.

  Biologics : targets & therapy 20070601

• In vitro cytotoxicity evaluation of some substituted isatin derivatives.

  Bioorganic & medicinal chemistry 20070115