208255-80-5 | Dapt

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$9.00	$6.00
5mg	98%	in stock	$25.00	$17.00
10mg	98%	in stock	$40.00	$28.00
25mg	98%	in stock	$70.00	$49.00
100mg	98%	in stock	$156.00	$109.00
1g	98%	in stock	$1,336.00	$935.00

Description

• Catalog Number: AB18509
• Chemical Name: Dapt
• CAS Number: 208255-80-5
• Molecular Formula: C23H26F2N2O4
• Molecular Weight: 432.4603
• MDL Number: MFCD04974585
• SMILES: O=C(N[C@H](C(=O)NC(c1ccccc1)C(=O)OC(C)(C)C)C)Cc1cc(F)cc(c1)F

Computed Properties

• Complexity: 622
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 9
• XLogP3: 3.7

Literature

• Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.

  Bioorganic & medicinal chemistry letters 20110501

• Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.

  Bioorganic & medicinal chemistry letters 20091215

• Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

  Journal of medicinal chemistry 20081211

• Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

  The Journal of biological chemistry 20071221

• Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

  The Journal of biological chemistry 20070824