208260-29-1 | Zm 336372

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$10.00	$7.00
5mg	98%	in stock	$26.00	$18.00
10mg	98%	in stock	$38.00	$26.00
50mg	98%	in stock	$102.00	$71.00
100mg	98%	in stock	$161.00	$113.00

Description

• Catalog Number: AB18540
• Chemical Name: Zm 336372
• CAS Number: 208260-29-1
• Molecular Formula: C23H23N3O3
• Molecular Weight: 389.44702
• MDL Number: MFCD02683971
• SMILES: Oc1ccc(cc1)C(=O)Nc1cc(ccc1C)NC(=O)c1cccc(c1)N(C)C

Computed Properties

• Complexity: 560
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 3.7

Literature

• Mechanisms of the inhibition of nuclear factor-κB by morphine in neuronal cells.

  Molecular pharmacology 20120401

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.

  The Journal of surgical research 20100601

• ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080501

• Pharmacophore identification of Raf-1 kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20080401

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.

  Surgery 20071201

• Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells.

  Toxicology 20060921

• Rational design of inhibitors that bind to inactive kinase conformations.

  Nature chemical biology 20060701

• ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.

  The Journal of surgical research 20060601

• Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.

  Free radical biology & medicine 20060315

• ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.

  Molecular cancer therapeutics 20050601

• A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.

  Bioorganic & medicinal chemistry letters 20041101

• The specificities of protein kinase inhibitors: an update.

  The Biochemical journal 20030401