2086-83-1 | Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$18.00	$12.00
100mg	98%	in stock	$25.00	$17.00
250mg	98%	in stock	$49.00	$34.00
1g	98%	in stock	$74.00	$52.00
5g	98%	in stock	$172.00	$121.00
25g	98%	in stock	$487.00	$341.00

Description

• Catalog Number: AB18769
• Chemical Name: Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-
• CAS Number: 2086-83-1
• Molecular Formula: C20H18NO4
• Molecular Weight: 336.3612
• MDL Number: MFCD01175817
• SMILES: COc1c(OC)ccc2c1c[n+]1CCc3c(-c1c2)cc1c(c3)OCO1

Computed Properties

• Complexity: 488
• Covalently-Bonded Unit Count: 1
• Formal Charge: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• XLogP3: 3.6

Literature

• The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins.

  Chemico-biological interactions 20180925

• Anti-apoptotic and moderate anti-inflammatory effects of berberine in sulfur mustard exposed keratinocytes.

  Toxicology letters 20180901

• Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR-γ and subsequent expression of HGF in colons.

  Toxicology and applied pharmacology 20180315

• Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101

• Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801

• Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice.

  Chemico-biological interactions 20170425

• Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.

  Toxicology and applied pharmacology 20170201

• Berberine acts as a putative epigenetic modulator by affecting the histone code.

  Toxicology in vitro : an international journal published in association with BIBRA 20161001

• Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.

  Toxicology and applied pharmacology 20160115

• Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/β-catenin signaling pathway.

  Toxicology letters 20160105

• Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II).

  Chemico-biological interactions 20151005

• The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats.

  Metabolic brain disease 20150801

• (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling.

  Psychopharmacology 20150301

• Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141201

• Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line.

  Chemico-biological interactions 20141105

• The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140701

• Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20140601

• Structural optimization of berberine as a synergist to restore antifungal activity of fluconazole against drug-resistant Candida albicans.

  ChemMedChem 20140101

• Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth.

  Toxicology and applied pharmacology 20131101

• Mechanism study of goldenseal-associated DNA damage.

  Toxicology letters 20130731

• Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: a biphasic experimental study.

  Toxicology letters 20130523

• Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.

  Reproductive toxicology (Elmsford, N.Y.) 20130401

• Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.

  Aging 20121201

• Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats.

  Journal of ethnopharmacology 20121121

• Berberine: new perspectives for old remedies.

  Biochemical pharmacology 20121115

• Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.

  Bioorganic & medicinal chemistry letters 20121115

• Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis.

  Molecular and cellular endocrinology 20121105

• Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell.

  European journal of pharmacology 20121105

• Interaction mechanism between berberine and the enzyme lysozyme.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

• Radiosensitization effects of berberine on human breast cancer cells.

  International journal of molecular medicine 20121101

• On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis.

  Analytical and bioanalytical chemistry 20121101

• Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.

  Analytica chimica acta 20121017

• Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.

  Journal of molecular biology 20121012

• Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling.

  Biochemical and biophysical research communications 20121005

• Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region.

  The pharmacogenomics journal 20121001

• Electrochemical oxidation of berberine and mass spectrometric identification of its oxidation products.

  Bioelectrochemistry (Amsterdam, Netherlands) 20121001

• Simultaneous quantification of berberine and lysergol by HPLC-UV: evidence that lysergol enhances the oral bioavailability of berberine in rats.

  Biomedical chromatography : BMC 20121001

• An isoquinoline alkaloid, berberine, can inhibit fungal alpha amylase: enzyme kinetic and molecular modeling studies.

  Chemical biology & drug design 20121001

• Possible therapeutic potential of berberine in diabetic osteopathy.

  Medical hypotheses 20121001

• Increased serotonergic neurotransmission is not responsible for the anticompulsive effect of berberine in a murine model of obsessive-compulsive disorder.

  Behavioural pharmacology 20121001

• Use of a lipid-lowering food supplement in patients on hormone therapy following breast cancer.

  Minerva ginecologica 20121001

• The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase.

  Journal of ethnopharmacology 20120928

• Berberine, an isoquinoline alkaloid, inhibits the metastatic potential of breast cancer cells via Akt pathway modulation.

  Journal of agricultural and food chemistry 20120926

• Synthesis and cytotoxicity evaluation of 13-n-alkyl berberine and palmatine analogues as anticancer agents.

  Molecules (Basel, Switzerland) 20120925

• Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages.

  European journal of pharmacology 20120905

• Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase.

  Phytotherapy research : PTR 20120901

• Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120901

• Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA).

  Planta medica 20120901

• Combining human periodontal ligament cell membrane chromatography with online HPLC/MS for screening osteoplastic active compounds from Coptidis Rhizoma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

• Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA).

  Molecules (Basel, Switzerland) 20120829

• Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules.

  Analytical chemistry 20120821

• Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

• Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.

  Analytica chimica acta 20120806

• The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells.

  European journal of pharmacology 20120805

• Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic action.

  Endocrinology 20120801

• Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana.

  Plant molecular biology 20120801

• Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine.

  Pharmaceutical biology 20120801

• Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.

  Bioorganic & medicinal chemistry letters 20120715

• Lipid-lowering effect of berberine in human subjects and rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120715

• Berberine acutely inhibits the digestion of maltose in the intestine.

  Journal of ethnopharmacology 20120713

• Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-α in breast cancer cells.

  The Journal of surgical research 20120701

• Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling.

  International journal of oncology 20120701

• Design, synthesis and multidrug resistance reversal activity evaluation of 8-oxocoptisine derivatives.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701

• Structural studies on ligand-DNA systems: A robust approach in drug design.

  Journal of biosciences 20120701

• Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells.

  Journal of proteomics 20120618

• Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120615

• Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA.

  ACS chemical biology 20120615

• Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines.

  Journal of chromatography. A 20120615

• Berberine ameliorates pro-inflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitro.

  Inflammation 20120601

• Synthesis, structure-activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives.

  European journal of medicinal chemistry 20120601

• Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells.

  Mutation research 20120601

• Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis.

  Immunopharmacology and immunotoxicology 20120601

• A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.

  Bioanalysis 20120601

• Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids.

  Archives of pharmacal research 20120601

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• Straightforward preparation of organic colloidal particles by harnessing spontaneous non-covalent interactions of active molecules from natural origin.

  Journal of colloid and interface science 20120515

• Berberine-induced haemolysis revisited: safety of Rhizoma coptidis and Cortex phellodendri in chronic haematological diseases.

  Phytotherapy research : PTR 20120501

• Drug-drug interactions between ketoconazole and berberine in rats: pharmacokinetic effects benefit pharmacodynamic synergism.

  Phytotherapy research : PTR 20120501

• Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention.

  Clinical and experimental pharmacology & physiology 20120501

• Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.

  Atherosclerosis 20120501

• Effects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with the metabolic syndrome.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20120501

• A combination of metabolomics and metallomics studies of urine and serum from hypercholesterolaemic rats after berberine injection.

  Analytical and bioanalytical chemistry 20120501

• Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.

  Bioorganic & medicinal chemistry 20120501

• Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx.

  Acta pharmacologica Sinica 20120501

• Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor-α.

  Investigative ophthalmology & visual science 20120430

• Simultaneous fluorescence light-up and selective multicolor nucleobase recognition based on sequence-dependent strong binding of berberine to DNA abasic site.

  Organic & biomolecular chemistry 20120428

• Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii.

  Bioorganic & medicinal chemistry letters 20120415

• Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects.

  Bioorganic & medicinal chemistry 20120415

• Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system.

  Journal of medicinal food 20120401

• Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway.

  Cancer science 20120401

• Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.

  Biopharmaceutics & drug disposition 20120401

• Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression.

  Diabetes 20120401

• CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines.

  Acta pharmacologica Sinica 20120401

• Antidiabetic properties of berberine: from cellular pharmacology to clinical effects.

  Hospital practice (1995) 20120401

• [Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

• High-performance liquid chromatography-electrospray ionization-mass spectrometry ligand fishing assay: a method for screening triplex DNA binders from natural plant extracts.

  Analytical chemistry 20120306

• Modulations of cytochrome P450 expression in diabetic mice by berberine.

  Chemico-biological interactions 20120305

• Molecular characterization, recombinant expression in Escherichia coli and biological activity of (S)-Tetrahydroberberine oxidase from Corydalis saxicola Bunt.

  Molecular biology reports 20120301

• Berberine prevents 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis: a biochemical approach.

  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120301

• Protective effect of berberine on serum glucose levels in non-obese diabetic mice.

  International immunopharmacology 20120301

• Chiral HPLC determination and stereoselective pharmacokinetics of tetrahydroberberine enantiomers in rats.

  Chirality 20120301

• Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus.

  The Journal of pharmacy and pharmacology 20120301

• Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1.

  Yonsei medical journal 20120301

• Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines.

  The journal of obstetrics and gynaecology research 20120301

• Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.

  Journal of pharmaceutical and biomedical analysis 20120223

• Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding.

  The journal of physical chemistry. B 20120223

• Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

• Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.

  Bioorganic & medicinal chemistry letters 20120215

• The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.

  Phytotherapy research : PTR 20120201

• Repeated administration of berberine inhibits cytochromes P450 in humans.

  European journal of clinical pharmacology 20120201

• Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

  Biochimica et biophysica acta 20120201

• Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase-9 activity following transient global cerebral ischemia.

  Journal of neuroscience research 20120201

• COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120201

• Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption.

  Drug metabolism and disposition: the biological fate of chemicals 20120201

• Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression.

  Biochemical pharmacology 20120201

• [Intestinal absorption of berberine alone and in combinations by rats single pass intestinal perfusion in situ].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120201

• PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.

  European journal of pharmacology 20120115

• Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells.

  Journal of natural medicines 20120101

• Effect of berberine on p53 expression by TPA in breast cancer cells.

  Oncology reports 20120101

• Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice.

  Planta medica 20120101

• Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism?

  Medical hypotheses 20120101

• A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.

  European journal of endocrinology 20120101

• Berberine induces heme oxygenase-1 up-regulation through phosphatidylinositol 3-kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes.

  International immunopharmacology 20120101

• Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators.

  Drug and chemical toxicology 20120101

• Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia.

  International immunopharmacology 20120101

• Analysis of goldenseal, Hydrastis canadensis L., and related alkaloids in urine using HPLC with UV detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101

• Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.

  Journal of biomedical science 20120101

• Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease.

  TheScientificWorldJournal 20120101

• The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene.

  PloS one 20120101

• G-quadruplex binding ligands: from naturally occurring to rationally designed molecules.

  Current pharmaceutical design 20120101

• Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings.

  The American journal of Chinese medicine 20120101

• Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor.

  PloS one 20120101

• Biophysical characterization of the strong stabilization of the RNA triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) alkyl ether berberine analogs.

  PloS one 20120101

• Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants.

  Biological & pharmaceutical bulletin 20120101

• Protective effects of berberine on doxorubicin-induced hepatotoxicity in mice.

  Biological & pharmaceutical bulletin 20120101

• Formation and conformation of baicalin-berberine and wogonoside-berberine complexes.

  Chemical & pharmaceutical bulletin 20120101

• [Preparation and stuctural behavior of the inclusion complex of beta-cyclodextrin and coptisine hydrochloride].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120101

• [Chemical constituents from Corydalis yanhusuo].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet.

  Lipids in health and disease 20120101

• Berberine inhibits growth and induces G1 arrest and apoptosis in human cholangiocarcinoma QBC939 cells.

  Journal of pharmacological sciences 20120101

• Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models.

  PloS one 20120101

• Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment.

  Lipids in health and disease 20120101

• Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation.

  Pharmacological reports : PR 20120101

• [Berberine activates volume-sensitive chloride channel in human colorectal carcinoma cells].

  Sheng li xue bao : [Acta physiologica Sinica] 20111225

• Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography-electrospray ionization-mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20111215

• Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line.

  Medical oncology (Northwood, London, England) 20111201

• Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.

  Inflammation 20111201

• Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism.

  Biotechnology and bioengineering 20111201

• Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription.

  Fitoterapia 20111201

• Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner.

  International immunopharmacology 20111201

• CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds.

  Drug metabolism and disposition: the biological fate of chemicals 20111201

• Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.

  European journal of medicinal chemistry 20111201

• Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells.

  Bioorganic & medicinal chemistry letters 20111201

• Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.

  Bioorganic & medicinal chemistry 20111201

• Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients.

  Advances in therapy 20111201

• [Effect of berberine on expression of transforming growth factor-beta1 and type IV collagen proteins in mesangial cells of diabetic rats with nephropathy].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201

• [Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201

• [Effect of different compatibility of Wuji Wan on bile excretion of representative ingredient].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201

• Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients.

  Molecules (Basel, Switzerland) 20111103

• Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.

  Medicinal research reviews 20111101

• Novel mitochondria-targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatine.

  Pharmaceutical research 20111101

• Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis).

  International immunopharmacology 20111101

• CYP2D plays a major role in berberine metabolism in liver of mice and humans.

  Xenobiotica; the fate of foreign compounds in biological systems 20111101

• Berberine inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-κB pathway in mast cells.

  International immunopharmacology 20111101

• Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms.

  Acta pharmacologica Sinica 20111101

• Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography.

  Journal of separation science 20111101

• Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy.

  PLoS neglected tropical diseases 20111101

• [Research on therapeutic effect and hemorrheology change of berberine in new diagnosed patients with type 2 diabetes combining nonalcoholic fatty liver disease].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

• Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine.

  Mini reviews in medicinal chemistry 20111101

• [Effect of enhanced UV-B radiation on metabolism and berberine content of Coptis chinensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

• Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice.

  Journal of ethnopharmacology 20111031

• Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma coptidis alkaloids.

  Journal of ethnopharmacology 20111031

• Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver.

  European journal of pharmacology 20111015

• Protective effect of berberine on expression pattern of apoptotic, cell proliferative, inflammatory and angiogenic markers during 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.

  Pakistan journal of biological sciences : PJBS 20111015

• Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

  Fitoterapia 20111001

• Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.

  Bioorganic & medicinal chemistry 20111001

• [Effects of berberine on the pancreatic beta cell apoptosis in rats with insulin resistance].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20111001

• [Correlation analysis soil nutrition as sell as yield and active compounds of Coptis teeta].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

• [Study on effect of berberine on modulating lipid and CPT I A gene expression].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

• [Extract berberine hydrochloride by aqueous two-phase system].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111001

• Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110918

• Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway.

  Molecular and cellular biochemistry 20110901

• Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine.

  Fitoterapia 20110901

• Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function.

  The Journal of pharmacology and experimental therapeutics 20110901

• Micelle to solvent stacking of two alkaloids in nonaqueous capillary electrophoresis.

  Journal of chromatography. A 20110826

• Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway.

  Journal of agricultural and food chemistry 20110810

• Berberine: a potential multipotent natural product to combat Alzheimer's disease.

  Molecules (Basel, Switzerland) 20110809

• Determination of ethambutol by a sensitive fluorescent probe.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110801

• The effects of jatrorrhizine on contractile responses of rat ileum.

  European journal of pharmacology 20110801

• Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice.

  Journal of agricultural and food chemistry 20110727

• Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).

  Journal of natural products 20110722

• Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids.

  Talanta 20110715

• Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells.

  Neuroscience letters 20110712

• Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147.

  Cancer science 20110701

• Antitumor effects of the combination of cholesterol reducing drugs.

  Oncology reports 20110701

• Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.

  Anti-cancer drugs 20110701

• Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells.

  European journal of pharmacology 20110701

• Berberine acutely activates the glucose transport activity of GLUT1.

  Biochimie 20110701

• Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica.

  Plant & cell physiology 20110701

• Berberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats.

  European journal of pharmacology 20110625

• Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes.

  FEBS letters 20110623

• Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.

  Behavioural brain research 20110620

• Identification of novel pregnane X receptor activators from traditional Chinese medicines.

  Journal of ethnopharmacology 20110614

• Effect of berberine and Berberis aetnensis C. Presl. alkaloid extract on glutamate-evoked tissue transglutaminase up-regulation in astroglial cell cultures.

  Phytotherapy research : PTR 20110601

• Protective effects of berberine in an experimental rat osteoarthritis model.

  Phytotherapy research : PTR 20110601

• In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures.

  Archives of oral biology 20110601

• Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.

  Fitoterapia 20110601

• Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia.

  The Journal of infectious diseases 20110601

• Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats.

  AAPS PharmSciTech 20110601

• Effects of cinnamon granules on pharmacokinetics of berberine in Rhizoma Coptidis granules in healthy male volunteers.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601

• [Quantitative analysis of four alkaloids in Xianglian preparations by QAMS method].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

• Recognition of molecularly imprinted polymers for a quaternary alkaloid of berberine.

  Talanta 20110530

• Fluorescence detection by intensity changes for high-performance thin-layer chromatography separation of lipids using automated multiple development.

  Journal of chromatography. A 20110513

• X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).

  Chemical communications (Cambridge, England) 20110507

• l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity.

  Synapse (New York, N.Y.) 20110501

• Oxidative damage and antioxidant responses in Microcystis aeruginosa exposed to the allelochemical berberine isolated from golden thread.

  Journal of plant physiology 20110501

• Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit.

  International journal of food sciences and nutrition 20110501

• Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.

  Planta medica 20110501

• Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene.

  European journal of medicinal chemistry 20110501

• Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93Å and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine.

  Biochimica et biophysica acta 20110501

• Potent antiprotozoal activity of a novel semi-synthetic berberine derivative.

  Bioorganic & medicinal chemistry letters 20110501

• Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome.

  Nutrition research (New York, N.Y.) 20110501

• Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect.

  Journal of natural products 20110425

• Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists.

  Toxicology and applied pharmacology 20110415

• Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes.

  Biochimica et biophysica acta 20110401

• Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat.

  Fitoterapia 20110401

• Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytes.

  Pharmacological research 20110401

• Application of 1H-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma.

  Journal of natural medicines 20110401

• Casparian bands occur in the periderm of Pelargonium hortorum stem and root.

  Annals of botany 20110401

• Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study.

  Biochimica et biophysica acta 20110401

• Synthesis of 9-substituted derivatives of berberine as anti-HIV agents.

  European journal of medicinal chemistry 20110401

• Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.

  Xenobiotica; the fate of foreign compounds in biological systems 20110401

• Vacuole-localized berberine bridge enzyme-like proteins are required for a late step of nicotine biosynthesis in tobacco.

  Plant physiology 20110401

• Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.

  Bioorganic & medicinal chemistry 20110401

• Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS.

  Advances in dental research 20110401

• Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions.

  Chinese medical journal 20110401

• [The synergistic antitumor effects of berberine alpha-hydroxy-beta-decanoylethyl sulfonate with hydroxycamptothecine and its effect on topoisomerase].

  Yao xue xue bao = Acta pharmaceutica Sinica 20110401

• Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro.

  European journal of pharmacology 20110311

• Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver.

  Fitoterapia 20110301

• Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-[kappa]B[alpha] phosphorylation and apoptosis in mice.

  Shock (Augusta, Ga.) 20110301

• Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110301

• A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity.

  Journal of biomolecular screening 20110301

• Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats.

  Chinese journal of integrative medicine 20110301

• [Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose diet].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110301

• Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice.

  Toxicology 20110204

• Thousand fold concentration of an alkaloid in capillary zone electrophoresis by micelle to solvent stacking.

  Journal of chromatography. A 20110204

• Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats.

  Metabolism: clinical and experimental 20110201

• The protective effect of berberine on β-cell lipoapoptosis.

  Journal of endocrinological investigation 20110201

• Berberine protects C57BL/6J mice against ethanol withdrawal-induced hyperexcitability.

  Phytotherapy research : PTR 20110201

• Enhanced DNA binding of 9-ω-amino alkyl ether analogs from the plant alkaloid berberine.

  DNA and cell biology 20110201

• Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins.

  International journal of oncology 20110201

• Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle.

  Toxicologic pathology 20110201

• [Antidiabetic activity of berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats].

  Georgian medical news 20110201

• [Changes of metabolic indices caused by berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats].

  Georgian medical news 20110201

• Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid.

  European journal of pharmacology 20110125

• Antiurolithic effect of berberine is mediated through multiple pathways.

  European journal of pharmacology 20110125

• Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages.

  International journal of cardiology 20110121

• Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells.

  European journal of pharmacology 20110115

• Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathway.

  Molecular and cellular endocrinology 20110101

• Antidiarrheal activity, chemical and toxicity profile of Berberis aristata.

  Pharmaceutical biology 20110101

• Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro.

  Fertility and sterility 20110101

• Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101

• Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors.

  Carcinogenesis 20110101

• Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis.

  Molecular carcinogenesis 20110101

• The effect of coptis chinensis on the signaling network in the squamous carcinoma cells.

  Frontiers in bioscience (Elite edition) 20110101

• Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.

  Journal of Alzheimer's disease : JAD 20110101

• Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis.

  PloS one 20110101

• Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages.

  PloS one 20110101

• Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria.

  PloS one 20110101

• Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells.

  Molecular cancer 20110101

• Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver x receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters.

  Biological & pharmaceutical bulletin 20110101

• Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.

  Journal of translational medicine 20110101

• Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.

  International journal of biological sciences 20110101

• Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway.

  Endocrine journal 20110101

• Modulating gut microbiota as an anti-diabetic mechanism of berberine.

  Medical science monitor : international medical journal of experimental and clinical research 20110101

• Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes.

  PloS one 20110101

• Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51.

  PloS one 20110101

• Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box.

  PloS one 20110101

• Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice.

  PloS one 20110101

• Berberine hydrochloride: anticancer activity and nanoparticulate delivery system.

  International journal of nanomedicine 20110101

• Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.

  PloS one 20110101

• Berberine attenuates doxorubicin-induced cardiotoxicity in mice.

  The Journal of international medical research 20110101

• Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.

  BMC neuroscience 20110101

• Protein kinase D activation stimulates the transcription of the insulin receptor gene.

  Molecular and cellular endocrinology 20101215

• Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism.

  Journal of cellular biochemistry 20101215

• Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease.

  Neuroscience letters 20101203

• Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells.

  Phytotherapy research : PTR 20101201

• Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San.

  Archives of virology 20101201

• Inhibitory effect of berberine on the motivational effects of ethanol in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20101201

• Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta.

  Neuropharmacology 20101201

• Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation.

  European journal of pharmacology 20101201

• Targeting metabolic syndrome: candidate natural agents.

  Journal of diabetes 20101201

• TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling.

  Journal of cell science 20101201

• Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.

  Bioorganic & medicinal chemistry letters 20101115

• Synthesis and antifungal activity of a novel series of 13-(4-isopropylbenzyl)berberine derivatives.

  Bioorganic & medicinal chemistry letters 20101115

• Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple.

  Journal of pharmaceutical and biomedical analysis 20101102

• Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20101101

• Berberine-induced activation of 5'-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles.

  Metabolism: clinical and experimental 20101101

• Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats.

  Planta medica 20101101

• Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway.

  Archives of biochemistry and biophysics 20101015

• Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis.

  Planta medica 20101001

• Anti-clastogenic effect of berberine against DMBA-induced clastogenesis.

  Basic & clinical pharmacology & toxicology 20101001

• Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis.

  Fitoterapia 20101001

• The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells.

  Cellular signalling 20101001

• Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20101001

• [Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

• [Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

• A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives.

  Chemical communications (Cambridge, England) 20100921

• Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages.

  Journal of cellular biochemistry 20100901

• Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine.

  Bioorganic & medicinal chemistry 20100901

• Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery.

  AAPS PharmSciTech 20100901

• [Synthesis and structure-activity relationship of 13-hexylberberine analogues as CD36 antagonists].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100901

• 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models.

  Bioorganic & medicinal chemistry 20100815

• Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

  Planta medica 20100801

• Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine.

  Diabetes 20100801

• Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine.

  Journal of immunology (Baltimore, Md. : 1950) 20100801

• Effects of berberine against radiation-induced intestinal injury in mice.

  International journal of radiation oncology, biology, physics 20100801

• Identification of berberine as a novel agonist of fatty acid receptor GPR40.

  Phytotherapy research : PTR 20100801

• [Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

• Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury.

  European journal of pharmacology 20100725

• Molecular characterization of O-methyltransferases involved in isoquinoline alkaloid biosynthesis in Coptis japonica.

  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721

• Berberine inhibits PTP1B activity and mimics insulin action.

  Biochemical and biophysical research communications 20100702

• Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.

  Fitoterapia 20100701

• The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells.

  Cell stress & chaperones 20100701

• Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.

  Epilepsy & behavior : E&B 20100701

• [Simultaneous determination of berberine, palmatine, matrine, catechin and baicalin in Funing Shuan by micellar electrokinetic capillary chromatography-electrospray ionization mass spectrometry].

  Se pu = Chinese journal of chromatography 20100701

• Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

  Bioorganic & medicinal chemistry 20100615

• L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.

  Neurobiology of aging 20100601

• Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation.

  Fitoterapia 20100601

• The mechanisms of ROS-photogeneration by berberine, a natural isoquinoline alkaloid.

  Journal of photochemistry and photobiology. B, Biology 20100601

• Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia.

  Journal of cellular biochemistry 20100601

• [Effects of berberine on serum levels of inflammatory factors and inflammatory signaling pathway in obese mice induced by high fat diet].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100601

• [Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders].

  Yao xue xue bao = Acta pharmaceutica Sinica 20100601

• Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics.

  Talanta 20100515

• Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells.

  Journal of ethnopharmacology 20100504

• The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

• Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial.

  Journal of bone and mineral metabolism 20100501

• Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells.

  Acta pharmacologica Sinica 20100501

• Berberine modulates insulin signaling transduction in insulin-resistant cells.

  Molecular and cellular endocrinology 20100412

• Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies.

  Biochemical pharmacology 20100401

• Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study.

  Naunyn-Schmiedeberg's archives of pharmacology 20100401

• Advance of studies on anti-atherosclerosis mechanism of berberine.

  Chinese journal of integrative medicine 20100401

• Effect of Huang-Lian-Jie-Du-Decoction on pharmacokinetics of verapamil in rats.

  The Journal of pharmacy and pharmacology 20100401

• [Simultaneous determination of the five alkaloids in Rhizoma Coptidis by nonaqueous capillary electrophoresis].

  Se pu = Chinese journal of chromatography 20100401

• Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters.

  Atherosclerosis 20100301

• Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders.

  Phytotherapy research : PTR 20100301

• Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.

  Current drug discovery technologies 20100301

• Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine.

  AAPS PharmSciTech 20100301

• Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophages.

  Canadian journal of physiology and pharmacology 20100301

• [In situ intestinal absorption kinetics of berberine and jatrorrhizine from extractive Rhizoma Coptidis in rats].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

• [Studies on NACE-DAD fingerprint of Cortex Phellodendri].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100301

• Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats.

  Journal of ethnopharmacology 20100217

• Microcalorimetric and spectrographic studies on the interaction of DNA with betaxolol.

  International journal of pharmaceutics 20100215

• Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.

  Metabolism: clinical and experimental 20100201

• In vitro antifungal activity of the berberine and its synergism with fluconazole.

  Antonie van Leeuwenhoek 20100201

• Transcriptional profile of the Shigella flexneri response to an alkaloid: berberine.

  FEMS microbiology letters 20100201

• Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

  Bioorganic & medicinal chemistry 20100201

• CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity.

  Acta pharmacologica Sinica 20100201

• [Controlling effect of berberine on in vitro synthesis and metabolism of steroid hormones in insulin resistant ovary].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100201

• [Comparison of pharmacokinetics about ermiao capsules and ermiao pellet].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201

• The application of digital image recognition to the analysis of two-dimensional fingerprints.

  Analytica chimica acta 20100111

• Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis.

  Mutation research 20100105

• A new benzylisoquinoline alkaloid from Argemone mexicana.

  Natural product research 20100101

• Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages.

  PloS one 20100101

• [Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

• [Effects of four components of Rhizoma Corydalis on anoxia and peroxidation injuries in neonatal cardiomyocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

• Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.

  Biological & pharmaceutical bulletin 20100101

• Rhizoma Coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway.

  Mediators of inflammation 20100101

• Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXRα and PPARα transcriptional programs.

  Endocrine journal 20100101

• [Hypoglycemic activity of berberin and extract obtained from the bark of Phellodendron lavalei, introduced in sub tropic areas of Georgia].

  Georgian medical news 20100101

• Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.

  Biological & pharmaceutical bulletin 20100101

• Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro.

  International journal of biological sciences 20100101

• Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice.

  PloS one 20100101

• Genetic evidence for inhibition of bacterial division protein FtsZ by berberine.

  PloS one 20100101

• Redox regulation of the AMP-activated protein kinase.

  PloS one 20100101

• High-performance thin layer chromatography for quality control of multicomponent herbal drugs: example of cangzhu xianglian san.

  Journal of AOAC International 20100101

• Enantioselective total synthesis of (-)-(S)-stepholidine.

  The Journal of organic chemistry 20091204

• Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.

  Medical hypotheses 20091201

• Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

• RNA-binding potential of protoberberine alkaloids: spectroscopic and calorimetric studies on the binding of berberine, palmatine, and coralyne to protonated RNA structures.

  DNA and cell biology 20091201

• Berberine improves free-fatty-acid-induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator-activated receptor gamma and fatty acid transferase expressions.

  Metabolism: clinical and experimental 20091201

• Matrix-free thin-layer chromatography/laser desorption ionization mass spectrometry for facile separation and identification of medicinal alkaloids.

  Rapid communications in mass spectrometry : RCM 20091201

• Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats.

  Journal of pharmaceutical sciences 20091101

• Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp.

  Phytotherapy research : PTR 20091101

• D(1)/D(2) receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice.

  Pharmacology, biochemistry, and behavior 20091101

• Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand.

  Schizophrenia research 20091101

• Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation.

  Journal of proteome research 20091101

• Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D(1) and antagonist at D(2) receptors, in rats.

  British journal of pharmacology 20091101

• Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor.

  Bioorganic & medicinal chemistry letters 20091101

• [8-hydroxy-dihydroberberine ameliorated insulin resistance induced by high FFA and high glucose in 3T3-L1 adipocytes].

  Yao xue xue bao = Acta pharmaceutica Sinica 20091101

• Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine.

  The Journal of biological chemistry 20091016

• Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin.

  European journal of pharmacology 20091012

• Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.

  The Journal of biological chemistry 20091009

• Interaction of isoquinoline alkaloids with an RNA triplex: structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)(*)poly(U).

  The journal of physical chemistry. B 20091008

• Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.

  The Journal of biological chemistry 20091002

• Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis.

  Journal of applied microbiology 20091001

• Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine.

  Journal of enzyme inhibition and medicinal chemistry 20091001

• Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.

  Bioorganic & medicinal chemistry letters 20091001

• Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901

• Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter.

  Journal of plant physiology 20090901

• Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901

• [Effects of extracts and active components of Rhizoma Coptidis on contraction of circular smooth muscle isolated from guinea pig gastric antrum].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901

• Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20090801

• Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

  Endocrinology 20090801

• The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells.

  Journal of cellular biochemistry 20090801

• Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage.

  Cell research 20090801

• [Study on effects of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase in vitro].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090801

• The examination of berberine excited state by laser flash photolysis.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090715

• Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.

  Cancer letters 20090708

• Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.

  Journal of ethnopharmacology 20090706

• Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research.

  The Journal of pharmacy and pharmacology 20090701

• [Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090701

• Berberine against gastrointestinal peptides elevation and mucous secretion in hyperthyroid diarrheic rats.

  Regulatory peptides 20090605

• Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group.

  Bioorganic & medicinal chemistry 20090601

• Berberine reduces the hypoxic-ischemic insult in rat pup brain.

  Acta physiologica Hungarica 20090601

• Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease.

  Saudi medical journal 20090601

• Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition.

  Molecular and cellular biochemistry 20090501

• Validation of a liquid chromatography-tandem mass spectrometric assay for the quantitative determination of hydrastine and berberine in human serum.

  Journal of pharmaceutical and biomedical analysis 20090501

• Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC.

  Journal of separation science 20090501

• [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

• Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats.

  World journal of gastroenterology 20090428

• Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.

  The Prostate 20090401

• Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.

  American journal of physiology. Endocrinology and metabolism 20090401

• Berberine suppresses proinflammatory responses through AMPK activation in macrophages.

  American journal of physiology. Endocrinology and metabolism 20090401

• Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells.

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090401

• [Study on vitro release and transdermal behaviors of Yulian cataplasm].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090401

• Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats.

  European journal of pharmacology 20090315

• Two-stage culture for producing berberine by cell suspension and shoot cultures of Berberis buxifolia Lam.

  Biotechnology letters 20090301

• [Effect of berberine on the differentiation and apoptosis of K562 cell line].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090301

• Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats.

  Chemico-biological interactions 20090212

• Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.

  The Journal of endocrinology 20090201

• Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells.

  Journal of molecular and cellular cardiology 20090201

• Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods.

  Biochimie 20090201

• [Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

• [Studies on the chemical constituents of Phellodendron chinense].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090201

• Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides.

  The journal of physical chemistry. B 20090129

• Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors.

  Brain research 20090123

• Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy.

  Journal of medicinal chemistry 20090122

• Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.

  Metabolism: clinical and experimental 20090101

• Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression.

  Biological & pharmaceutical bulletin 20090101

• New alkaloids from Corydalis species.

  Natural product research 20090101

• Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine.

  Journal of gastroenterology 20090101

• [Drug discovery based on classic natural products].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090101

• [Study on traditional Chinese medicine extracts of rhizoma coptidis by FTIR spectroscopy].

  Guang pu xue yu guang pu fen xi = Guang pu 20090101

• Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.

  Journal of Asian natural products research 20090101

• Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives.

  Journal of Asian natural products research 20090101

• Development of a rapid resolution liquid chromatographic method for simultaneous analysis of four alkaloids in Rhizoma coptidis under different cultivation conditions.

  Journal of AOAC International 20090101

• Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

  Phytochemical analysis : PCA 20090101

• Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes.

  Free radical research 20090101

• Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells.

  Immunopharmacology and immunotoxicology 20090101

• Neuroprotective effects of berberine on stroke models in vitro and in vivo.

  Neuroscience letters 20081205

• Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells.

  Molecules (Basel, Switzerland) 20081203

• Berberine decreases PCSK9 expression in HepG2 cells.

  Atherosclerosis 20081201

• Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20081201

• LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine.

  Biomedical chromatography : BMC 20081201

• Covalent bonding of azoles to quaternary protoberberine alkaloids.

  Magnetic resonance in chemistry : MRC 20081201

• DNA-binding cytotoxic alkaloids: comparative study of the energetics of binding of berberine, palmatine, and coralyne.

  DNA and cell biology 20081201

• A concerted mechanism for berberine bridge enzyme.

  Nature chemical biology 20081201

• [Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

• Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus.

  Chinese medical journal 20081105

• Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101

• Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats.

  Atherosclerosis 20081101

• Antiinflammatory effect of the ethanol extract of Berberis koreana in a gerbil model of cerebral ischemia/reperfusion.

  Phytotherapy research : PTR 20081101

• Isolation and identification of urinary metabolites of berberine in rats and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20081101

• Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells.

  Bioscience, biotechnology, and biochemistry 20081101

• [Five alkaloids from vine stems of Diploclisia affinis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• [Effects of berberine on cell proliferation, peroxisome proliferation activated receptor gamma, CAAT/enhancer binding protein mRNA and protein expression in 3T3-L1 pre-adipocytes].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081101

• [Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101

• Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity.

  World journal of gastroenterology 20081021

• Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.

  The Journal of biological chemistry 20080926

• Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii.

  Journal of ethnopharmacology 20080902

• Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway.

  Endocrinology 20080901

• Induced ion currents and the endothelin pathway as targets for anti-arrhythmic agents.

  Current opinion in investigational drugs (London, England : 2000) 20080901

• [Advance on study in anti-atherosclerosis mechanism of berberine].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• [Effects of berberine on expression of hepatocyte nuclear factor 4alpha and glucokinase activity in mouse primary hepatocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells.

  European journal of pharmacology 20080820

• Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators.

  Bioorganic & medicinal chemistry letters 20080815

• QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

  Biochemistry 20080805

• The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist.

  Psychopharmacology 20080801

• Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine.

  Phytotherapy research : PTR 20080801

• Combination of simvastatin with berberine improves the lipid-lowering efficacy.

  Metabolism: clinical and experimental 20080801

• Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.

  The Journal of pharmacy and pharmacology 20080801

• [Advances in the study of berberine and its derivatives].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080801

• On the mechanism of antidepressant-like action of berberine chloride.

  European journal of pharmacology 20080728

• Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula.

  Journal of ethnopharmacology 20080723

• Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose.

  Archives of biochemistry and biophysics 20080715

• Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.

  The Journal of clinical endocrinology and metabolism 20080701

• Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.

  Cancer research 20080701

• [Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient].

  Ying yong sheng tai xue bao = The journal of applied ecology 20080701

• [Study on self-microemulsifying drug delivery system of Jiaotai Pill active components].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

• Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction.

  Cellular and molecular neurobiology 20080601

• Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity.

  Journal of human hypertension 20080601

• Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats.

  Biological & pharmaceutical bulletin 20080601

• Traditional chinese medicine in treatment of metabolic syndrome.

  Endocrine, metabolic & immune disorders drug targets 20080601

• Effect of berberine on expression of hepatocyte nuclear factor-4alpha in rats with fructose-induced insulin resistance.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601

• Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway.

  Endocrine 20080601

• Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation.

  Toxicology and applied pharmacology 20080515

• Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line.

  Cancer chemotherapy and pharmacology 20080501

• Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080501

• Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism.

  Clinical and experimental pharmacology & physiology 20080501

• Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.

  Diabetes 20080501

• Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice.

  Shock (Augusta, Ga.) 20080501

• Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif.

  Acta pharmacologica Sinica 20080501

• Efficacy of berberine in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20080501

• Berberine, a natural product, combined with cisplatin enhanced apoptosis through a mitochondria/caspase-mediated pathway in HeLa cells.

  Biological & pharmaceutical bulletin 20080501

• Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats.

  Die Pharmazie 20080501

• [Absorption of extractive Rhizoma Coptidis in rat everted gut scas].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase.

  Chinese medical journal 20080420

• Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects.

  Bioorganic & medicinal chemistry 20080401

• Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway.

  Biological & pharmaceutical bulletin 20080401

• Berberine targets assembly of Escherichia coli cell division protein FtsZ.

  Biochemistry 20080311

• Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry.

  Journal of mass spectrometry : JMS 20080301

• Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.

  Clinical and experimental pharmacology & physiology 20080301

• Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301

• Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response.

  International journal of molecular medicine 20080301

• [Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080301

• [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080301

• Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta.

  World journal of gastroenterology 20080214

• Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways.

  European journal of pharmacology 20080202

• Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).

  Naunyn-Schmiedeberg's archives of pharmacology 20080201

• Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.

  International journal of radiation oncology, biology, physics 20080201

• Relaxant action mechanism of berberine identified as the active principle of Argemone ochroleuca Sweet in guinea-pig tracheal smooth muscle.

  The Journal of pharmacy and pharmacology 20080201

• Galactinol synthase gene of Coptis japonica is involved in berberine tolerance.

  Bioscience, biotechnology, and biochemistry 20080201

• Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives.

  Planta medica 20080201

• Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma.

  British journal of cancer 20080129

• Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons.

  Biomedical chromatography : BMC 20080101

• Berberine improves glucose metabolism through induction of glycolysis.

  American journal of physiology. Endocrinology and metabolism 20080101

• The microenvironment of DNA switches the activity of singlet oxygen generation photosensitized by berberine and palmatine.

  Photochemistry and photobiology 20080101

• Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine.

  Archives of pharmacal research 20080101

• Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide.

  BMC cancer 20080101

• Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro.

  In vivo (Athens, Greece) 20080101

• Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study.

  Journal of AOAC International 20080101

• Estimation of berberine in ayurvedic formulations containing Berberis aristata.

  Journal of AOAC International 20080101

• The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model.

  Experimental diabetes research 20080101

• Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv.

  Journal of experimental therapeutics & oncology 20080101

• Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells.

  Cancer letters 20071218

• Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells.

  Journal of agricultural and food chemistry 20071212

• Simultaneous quantification of three alkaloids of Coptidis Rhizoma in rat urine by high-performance liquid chromatography: application to pharmacokinetic study.

  Biopharmaceutics & drug disposition 20071201

• Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide.

  Acta pharmacologica Sinica 20071201

• Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat.

  The Journal of pharmacy and pharmacology 20071201

• [Molecular mechanism of berberine in improving insulin resistance induced by free fatty acid through inhibiting nuclear trascription factor-kappaB p65 in 3T3-L1 adipocytes].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071201

• [Absorption of coptisine chloride and berberrubine across human intestinal epithelial by using human Caco-2 cell monolayers].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

• [Fast and simultaneous determination of four index components in Qingwei Huanglian tablets by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201

• Effect of berberine on PPARalpha/delta/gamma expression in type 2 diabetic rat retinae.

  Yao xue xue bao = Acta pharmaceutica Sinica 20071201

• Supramolecular interaction of ethylenediamine linked beta-cyclodextrin dimer and berberine hydrochloride by spectrofluorimetry and its analytical application.

  Talanta 20071115

• Berberine-induced LDLR up-regulation involves JNK pathway.

  Biochemical and biophysical research communications 20071103

• Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

  The Journal of pharmacology and experimental therapeutics 20071101

• Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes.

  Biological & pharmaceutical bulletin 20071101

• [Recent advances in the study of antifungal lead compounds with new chemical scaffolds].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071101

• [Effect of berberine on insulin secretion and glucokinase activity of NIT-1 cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• [Refinement study of macroporous resin for Huang-Lian-Jie-Du decoction].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001

• Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20070921

• Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives.

  Medicinal research reviews 20070901

• Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

  Biophysical journal 20070901

• Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.

  Pharmacological research 20070901

• Determination of colchicine in mouse plasma by high performance liquid-chromatographic method with UV detection and its application to pharmacokinetic studies.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901

• Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice.

  Life sciences 20070823

• Determination of berberine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070815

• Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride.

  European journal of pharmacology 20070813

• Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry.

  Journal of chromatography. A 20070803

• Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response.

  Letters in applied microbiology 20070801

• [Studies on chemical constituents in fresh fleshy scaleleaf of Lilium lancifolium].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

• [Preparation and examination of the vitro releasing of pH-dependent kuijiekang tablet for colon-specific delivery].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801

• Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine.

  Acta pharmacologica Sinica 20070701

• Theoretical analysis of tablet hardness prediction using chemoinformetric near-infrared spectroscopy.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070701

• [Simultaneous determination of geniposide, baicalin and berberine hydrochloride in Angong Niuhuang pill by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070701

• Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.

  Cancer letters 20070628

• Analysis of berberine and total alkaloid content in cortex phellodendri by near infrared spectroscopy (NIRS) compared with high-performance liquid chromatography coupled with ultra-visible spectrometric detection.

  Analytica chimica acta 20070605

• Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.

  Acta pharmacologica Sinica 20070601

• Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

• l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons.

  Acta pharmacologica Sinica 20070501

• Inclusion effect and structural basis of cyclodextrins for increased extraction of medicinal alkaloids from natural medicines.

  Chemical & pharmaceutical bulletin 20070501

• [Influence of compatibility on content of berberine in Maxingganshi decoction].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070501

• Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala.

  Bioorganic & medicinal chemistry letters 20070401

• Effect of baicalin and berberine on transport of nimodipine on primary-cultured, rat brain microvascular endothelial cells.

  Acta pharmacologica Sinica 20070401

• High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.

  Journal of separation science 20070401

• Antiviral activity of berberine and related compounds against human cytomegalovirus.

  Bioorganic & medicinal chemistry letters 20070315

• Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017.

  Naunyn-Schmiedeberg's archives of pharmacology 20070301

• Berberine stimulates glucose transport through a mechanism distinct from insulin.

  Metabolism: clinical and experimental 20070301

• The natural product berberine is a human prolyl oligopeptidase inhibitor.

  ChemMedChem 20070301

• Diagnosis and therapy of oral squamous cell carcinoma.

  Expert review of anticancer therapy 20070301

• Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20070201

• The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats.

  Neuropharmacology 20070201

• Screening of acetylcholinesterase inhibitors in natural extracts by CE with electrophoretically mediated microanalysis technique.

  Electrophoresis 20070201

• RNA binding small molecules: studies on t-RNA binding by cytotoxic plant alkaloids berberine, palmatine and the comparison to ethidium.

  Biophysical chemistry 20070201

• Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.

  The FEBS journal 20070201

• [Protective action of effective components of Huanglian Jiedu decoction on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070201

• Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion.

  Biochemical and biophysical research communications 20070112

• Human MDR1 and MRP1 recognize berberine as their transport substrate.

  Bioscience, biotechnology, and biochemistry 20070101

• Effect of berberine on barrier function in a human retinal pigment epithelial cell line.

  Japanese journal of ophthalmology 20070101

• Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation.

  Arzneimittel-Forschung 20070101

• Effects of oral administration of berberine on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats.

  In vivo (Athens, Greece) 20070101

• Berberine inhibits WEHI-3 leukemia cells in vivo.

  In vivo (Athens, Greece) 20070101

• Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA.

  Rapid communications in mass spectrometry : RCM 20070101

• Polygonum cuspidatum, compared with baicalin and berberine, inhibits inducible nitric oxide synthase and cyclooxygenase-2 gene expressions in RAW 264.7 macrophages.

  Vascular pharmacology 20070101

• Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway.

  Anticancer research 20070101

• GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cells.

  Anticancer research 20070101

• Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria.

  Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia 20070101

• Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications.

  Current medicinal chemistry 20070101

• Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte.

  Experimental & molecular medicine 20061231

• Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry.

  Drug metabolism and disposition: the biological fate of chemicals 20061201

• Nanostructured electrochemical DNA biosensors for detection of the effect of berberine on DNA from cancer cells.

  Analytical and bioanalytical chemistry 20061201

• Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway.

  Oncology reports 20061201

• Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats.

  Journal of ethnopharmacology 20061103

• Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice.

  Neuroscience 20061103

• Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.

  Biochimica et biophysica acta 20061101

• 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.

  Biological & pharmaceutical bulletin 20061101

• Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP.

  Carcinogenesis 20061001

• The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms.

  Journal of lipid research 20061001

• [Quality analysis and evaluation of Rhizoma Coptidis under different cultivation conditions].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061001

• [Determination of 3 kinds of components in huanglian jiedu decoction by HPLC under different UV wavelengths].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

• Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway.

  Biochemical and biophysical research communications 20060922

• Effects of (-)stepholidine in animal models for schizophrenia.

  Acta pharmacologica Sinica 20060901

• In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine.

  Biological & pharmaceutical bulletin 20060901

• Pharmacological properties of traditional medicine (XXXII): protective effects of hangeshashinto and the combinations of its major constituents on gastric lesions in rats.

  Biological & pharmaceutical bulletin 20060901

• Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection.

  Journal of separation science 20060901

• [Liquid chromatography-tandem electrospray ionization ion trap mass spectrometric assay for the metabolites of jatrorrhizine in rat urine].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060901

• Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells.

  Cancer letters 20060808

• Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents.

  Bioorganic & medicinal chemistry letters 20060801

• Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line.

  Life sciences 20060801

• Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states.

  Diabetes 20060801

• Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA.

  Bioorganic & medicinal chemistry 20060701

• [Fingerprints of Rhizoma Coptidis from Shizhu by HPLC].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060701

• Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060621

• Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction.

  Journal of pharmaceutical and biomedical analysis 20060607

• Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.

  Journal of lipid research 20060601

• The Galpha protein controls a pH-dependent signal path to the induction of phytoalexin biosynthesis in Eschscholzia californica.

  The Plant cell 20060601

• Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine.

  Chemical research in toxicology 20060601

• Nonaqueous capillary electrophoresis coupled with laser-induced native fluorescence detection for the analysis of berberine, palmatine, and jatrorrhizine in Chinese herbal medicines.

  Journal of separation science 20060601

• Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20060501

• Acetylcholinesterase inhibitors from Stephania venosa tuber.

  The Journal of pharmacy and pharmacology 20060501

• [Assessment of taste development in 62 newborn infants].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20060501

• Berberry extract reduces neuronal damage and N-Methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia.

  Biological & pharmaceutical bulletin 20060401

• Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation.

  Journal of enzyme inhibition and medicinal chemistry 20060401

• [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060401

• Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method.

  Journal of pharmaceutical and biomedical analysis 20060318

• [The content condition of effective composition in Sanhuang Xiexin decoction].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301

• [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060301

• Simultaneous determination of four active alkaloids from a traditional Chinese medicine Corydalis saxicola Bunting. (Yanhuanglian) in plasma and urine samples by LC-MS-MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

• The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC).poly(rG): spectroscopic and viscometric study.

  Bioorganic & medicinal chemistry 20060201

• Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors.

  Bioorganic & medicinal chemistry 20060201

• Chiral high-performance liquid chromatographic separation of the enantiomers of tetrahydropalmatine and tetrahydroberberine, isolated from Corydalis yanhusuo.

  Analytical and bioanalytical chemistry 20060201

• Metabolites of the 'smoke tree', Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus.

  Journal of natural products 20060201

• Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.

  Molecular cancer therapeutics 20060201

• A rapid and simple determination of protoberberine alkaloids in cortex phellodendri by 1H NMR and its application for quality control of commercial traditional Chinese medicine prescriptions.

  Journal of pharmaceutical and biomedical analysis 20060123

• Synthesis, DNA-binding affinities, and binding mode of berberine dimers.

  Bioorganic & medicinal chemistry 20060101

• Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line.

  Ophthalmic research 20060101

• The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers.

  Methods and findings in experimental and clinical pharmacology 20060101

• Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20060101

• CPU86017: a novel Class III antiarrhythmic agent with multiple actions at ion channels.

  Cardiovascular drug reviews 20060101

• Berberine inhibits the production of lysophosphatidylcholine-induced reactive oxygen species and the ERK1/2 pathway in vascular smooth muscle cells.

  Molecules and cells 20051231

• Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway.

  Journal of cardiovascular pharmacology 20051201

• Antiproliferative activity of berberine in vitro and in vivo.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

• Rational method development strategies on a fluorinated liquid chromatography stationary phase: mobile phase ion concentration and temperature effects on the separation of ephedrine alkaloids.

  Journal of chromatography. A 20051118

• Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an 'in vitro' replicative system.

  Antiviral research 20051101

• CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway.

  Acta pharmacologica Sinica 20051101

• Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice.

  Acta pharmacologica Sinica 20051101

• Cytotoxic constituents from the whole plant of Corydalis pallida.

  Archives of pharmacal research 20051101

• [Studies on the alkaloids from herb of Corydalis adunca].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101

• Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract.

  Life sciences 20051028

• Synthesis and DNA-binding affinities of monomodified berberines.

  Bioorganic & medicinal chemistry 20051015

• Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells.

  Biochemical pharmacology 20051015

• Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi.

  Current microbiology 20051001

• Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine.

  Arteriosclerosis, thrombosis, and vascular biology 20051001

• Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells.

  Journal of biomedical science 20051001

• The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction.

  Chemical research in toxicology 20051001

• Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1.

  Biochemical pharmacology 20050915

• Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study.

  European journal of clinical pharmacology 20050901

• Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum.

  Electrophoresis 20050901

• [Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers].

  Chinese journal of integrative medicine 20050901

• [HPLC fingerprint for the Corydalis saxicola Bunting injection].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050901

• LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivation.

  Analytical biochemistry 20050815

• Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt.

  Neuroscience letters 20050805

• Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica.

  Plant physiology 20050801

• Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma.

  Biological & pharmaceutical bulletin 20050801

• Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes.

  Cellular & molecular immunology 20050801

• [Effects of berberine on DNFB-induced delayed type hypersensitivity in mice].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20050701

• [Chemical constituents from Corydalis humosa].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701

• Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect.

  British journal of pharmacology 20050601

• Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts.

  Electrophoresis 20050601

• [Effects of berberine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro].

  Zhonghua nan ke xue = National journal of andrology 20050601

• Berberine--a novel approach to cholesterol lowering.

  Expert opinion on investigational drugs 20050501

• Inhibitory effects of Stephania tetrandra S. Moore on free radical-induced lysis of rat red blood cells.

  Biological & pharmaceutical bulletin 20050401

• Search of chemical scaffolds for novel antituberculosis agents.

  Journal of biomolecular screening 20050401

• [Quality assessment of Coptis chinensis in China].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

• Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis.

  The Plant cell 20050301

• Berberine synergy with amphotericin B against disseminated candidiasis in mice.

  Biological & pharmaceutical bulletin 20050301

• Cheap Chinese herb lowers cholesterol.

  Health news (Waltham, Mass.) 20050301

• Binding of the bioactive component jatrorrhizine to human serum albumin.

  Biochimica et biophysica acta 20050211

• Regeneration of Psychotria umbellata and production of the analgesic indole alkaloid umbellatine.

  Tree physiology 20050201

• Effects of l-stepholidine on forebrain Fos expression: comparison with clozapine and haloperidol.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050201

• [Study on the interaction of anticancer drugs and DNA using fluorescence spectroscopy].

  Guang pu xue yu guang pu fen xi = Guang pu 20050201

• Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts.

  Bioscience, biotechnology, and biochemistry 20050101

• Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis.

  Journal of separation science 20050101

• Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells.

  In vivo (Athens, Greece) 20050101

• A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis.

  American journal of therapeutics 20050101

• Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells.

  Anticancer research 20050101

• Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption.

  Biotechnology progress 20050101

• Pharmacokinetics of berberine in rat thalamus after intravenous administration of Coptidis rhizoma extract.

  The American journal of Chinese medicine 20050101

• Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.

  Journal of medicinal food 20050101

• Hypoglycemic activity of jatrorrhizine.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• [Berberine and amitozine binding with calf thymus DNA].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

• Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila.

  Journal of neurobiology 20041201

• Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.

  Nature medicine 20041201

• [Effect of berberine on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosum].

  Zhonghua nan ke xue = National journal of andrology 20041201

• [Establishment of the control substance of plant drug and fingerprints of Coptis chinensis].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201

• Structural elucidation and identification of alkaloids in Rhizoma Coptidis by electrospray ionization tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20041101

• Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.

  Archives of pharmacal research 20041101

• Study on the precipitation reaction between baicalin and berberine by HPLC.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015

• Inhibitory effects of berberine on ion channels of rat hepatocytes.

  World journal of gastroenterology 20041001

• Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors.

  Life sciences 20041001

• Recent pharmacological studies on natural products in China.

  European journal of pharmacology 20041001

• [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001

• Improved detection of Coptidis alkaloids by field-amplified sample stacking in capillary electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20040921

• Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908

• Berberine inhibits HIF-1alpha expression via enhanced proteolysis.

  Molecular pharmacology 20040901

• [The clinical study on the adjunctive effects of aqueous extract from coptis root for the treatment of chronic periodontitis].

  Shanghai kou qiang yi xue = Shanghai journal of stomatology 20040801

• Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium.

  Phytotherapy research : PTR 20040801

• Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids.

  Phytotherapy research : PTR 20040801

• Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents.

  Biochemical and biophysical research communications 20040702

• Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

  British journal of pharmacology 20040701

• In vitro cytotoxicity of berberine against HeLa and L1210 cancer cell lines.

  Die Pharmazie 20040701

• Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats.

  Acta pharmacologica Sinica 20040601

• Determination of rhein, baicalin and berberine in traditional Chinese medicinal preparations by capillary electrophoresis with two-marker technique.

  Biomedical chromatography : BMC 20040601

• Effect of auxins on berberine synthesis in cell suspension culture of Coscinium fenestratum (Gaertn.) Colebr--a critically endangered medicinal liana of Western Ghats.

  Indian journal of experimental biology 20040601

• Neurotrophin-3 regulates mast cell functions in neonatal mouse skin.

  Experimental dermatology 20040501

• A selective and sensitive assay of berberine using total internal reflected resonance light scattering technique with fluorescein at the water/1,2-dichloroethane interface.

  Journal of pharmaceutical and biomedical analysis 20040401

• Hepatobiliary excretion of berberine.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• Blockade of L-type calcium channel in myocardium and calcium-induced contractions of vascular smooth muscle by CPU 86017.

  Acta pharmacologica Sinica 20040401

• Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion.

  Acta pharmacologica Sinica 20040401

• [Screening for inhibitors of tumor invasion into basement membranes].

  Gan to kagaku ryoho. Cancer & chemotherapy 20040401

• Determination of mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill by high-performance liquid chromatography.

  Journal of chromatographic science 20040401

• Cytotoxic activity of five compounds isolated from Colombian plants.

  Fitoterapia 20040301

• [Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040301

• Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis.

  International immunopharmacology 20040301

• [Extraction and HPLC analysis of alkaloids in goldenseal].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040301

• Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus.

  Brain research 20040227

• Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids.

  Bioscience, biotechnology, and biochemistry 20040201

• [Distribution of four alkaloids in plants of Berberis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201

• The anti-inflammatory potential of berberine in vitro and in vivo.

  Cancer letters 20040120

• Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.

  Biological & pharmaceutical bulletin 20040101

• Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth.

  Clinical and experimental pharmacology & physiology 20040101

• Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel.

  Archives of pharmacal research 20040101

• A new approach to investigate the pharmacokinetics of traditional chinese medicine YL2000.

  The American journal of Chinese medicine 20040101

• [Simultaneous determination of berberin hydrochloride, baicalin and glibenclamide in kangtang tablets by RP-HPLC].

  Se pu = Chinese journal of chromatography 20040101

• [The interaction of berberine and human serum albumin].

  Guang pu xue yu guang pu fen xi = Guang pu 20040101

• Transport and uptake characteristics of a new derivative of berberine (CPU-86017) by human intestinal epithelial cell line: Caco-2.

  Acta pharmacologica Sinica 20031201

• Cytotoxicity and DNA binding properties of the plant alkaloid burasaine.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20031201

• [Inhibitory action of berberine on glucose absorption].

  Yao xue xue bao = Acta pharmaceutica Sinica 20031201

• [Determination of four alkaloids in Berberis plants by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

• Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray.

  International journal of cancer 20031120

• Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.

  The Journal of biological chemistry 20031003

• Berberine formate-succinic acid (1/1).

  Acta crystallographica. Section C, Crystal structure communications 20031001

• [Precipitation reaction between berberine and rheinic acid by capillary electrophoresis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20031001

• Isoflavones as potentiators of antibacterial activity.

  Journal of agricultural and food chemistry 20030910

• [The inhibit effect of berberine on human colon cell line cyclooxygenase-2].

  Zhonghua nei ke za zhi 20030801

• Determination of berberine by measuring the enhanced total internal reflected fluorescence at water/tetrachloromethane interface in the presence of sodium dodecyl benzene sulfonate.

  Analytical and bioanalytical chemistry 20030701

• Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin.

  International journal of antimicrobial agents 20030701

• High-performance capillary electrophoresis for determining the contents of berberine, jatrorrhizine and palmatine in Gegenqinlian decoction.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030701

• The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption.

  Planta medica 20030701

• [Protective effect of berberine on cardiac myocyte injured by ischemia-reperfusion].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20030701

• [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701

• Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells.

  Planta medica 20030601

• Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance.

  European journal of pharmacology 20030523

• Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy.

  Life sciences 20030418

• Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures.

  Journal of biomolecular structure & dynamics 20030401

• Palmatine and berberine isolation artifacts.

  Journal of natural products 20030401

• Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2).

  Bioorganic & medicinal chemistry 20030220

• Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins.

  Plant & cell physiology 20030201

• Thalictrum minus cell cultures and ABC-like transporter.

  Phytochemistry 20030201

• A simple method for fabrication of silver-coated sheathless electrospray emitters.

  Rapid communications in mass spectrometry : RCM 20030101

• Variations in alkaloid content of herbal products containing goldenseal.

  Journal of the American Pharmacists Association : JAPhA 20030101

• P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers.

  Journal of pharmaceutical sciences 20021201

• Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus.

  Planta medica 20021201

• (-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro.

  Neuroreport 20021115

• Effects of berberine on glucose metabolism in vitro.

  Metabolism: clinical and experimental 20021101

• Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver.

  Archives of toxicology 20021101

• Immunocytological localization of two enzymes involved in berberine biosynthesis.

  Planta 20021101

• Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids.

  Bioscience, biotechnology, and biochemistry 20021101

• [Determination of alkaloids from Coptis chinensis Franch. and Phellodendron amurense Rupr. Decocted together in baitouweng decocta by high performance capillary electrophoresis].

  Se pu = Chinese journal of chromatography 20021101

• A sensitive optode membrane for berberine using conjugated polymer as sensing material.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20021001

• The involvement of P-glycoprotein in berberine absorption.

  Pharmacology & toxicology 20021001

• [In situ thin layer chromatography-fourier transform-surface-enhanced Raman spectrum study on ingredients of berberine].

  Guang pu xue yu guang pu fen xi = Guang pu 20021001

• Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.

  Journal of experimental botany 20020901

• Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells.

  Neurochemical research 20020901

• [Determination of furazolidone, carbenoxolone sodium and berberine hydrochloride in wei kang tablets by reversed-phase high performance liquid chromatography(RP-HPLC)].

  Se pu = Chinese journal of chromatography 20020701

• Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to high-performance liquid chromatography.

  Journal of chromatography. A 20020628

• Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei.

  Die Pharmazie 20020601

• Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid.

  Biochemical pharmacology 20020515

• Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells.

  Thrombosis research 20020515

• Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma.

  International journal of cancer 20020510

• [The changes of some chemical components in banxiaxiexintang decoction of different combinations].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020501

• Selective inhibition of MAPKK Wis1 in the stress-activated MAPK cascade of Schizosaccharomyces pombe by novel berberine derivatives.

  The Journal of biological chemistry 20020405

• A validated high performance liquid chromatographic method for the analysis of Goldenseal.

  The Journal of pharmacy and pharmacology 20020301

• Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.

  Planta medica 20020301

• Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives.

  Planta medica 20020301

• Functional cloning and characterization of a plant efflux carrier for multidrug and heavy metal detoxification.

  The Journal of biological chemistry 20020215

• Study on the resonance light scattering spectrum of berberine-cetyltrimethylammonium bromide system and the determination of nucleic acids at nanogram levels.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020201

• Thermodynamic study on the effects of beta-cyclodextrin inclusion with berberine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020115

• [Inhibitory action of CPU86035 on L-type calcium current in single ventricular myocyte of guinea pig].

  Zhonghua yi xue za zhi 20020110

• (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions.

  Trends in pharmacological sciences 20020101

• Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration.

  Acta pharmacologica Sinica 20020101

• Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium.

  BMC complementary and alternative medicine 20020101

• [Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood].

  Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101

• Effect of berberine and (+/-)-bicuculline isolated from Corydalis chaerophylla on spore germination of some fungi.

  Folia microbiologica 20020101

• [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis].

  Likars'ka sprava 20020101

• Antimicrobial activity of berberine--a constituent of Mahonia aquifolium.

  Folia microbiologica 20020101

• Inhibition of type A monoamine oxidase by coptisine in mouse brain.

  Life sciences 20011228

• Structural mechanisms of QacR induction and multidrug recognition.

  Science (New York, N.Y.) 20011207

• Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane.

  IUBMB life 20011201

• Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung.

  European journal of pharmacology 20011116

• Enhanced tumor necrosis factor-alpha-specific and decreased interleukin-10-specific immune responses to LPS during the third trimester of pregnancy in mice.

  The Journal of endocrinology 20011101

• Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine.

  Chemical research in toxicology 20011101

• Gastric-mucous membrane protection activity of coptisine derivatives.

  Biological & pharmaceutical bulletin 20011101

• [Anticomplement activity of Mahonia aquifolium bisbenzylisoquinoline alkaloids and berberine extract].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101

• [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901

• [Study on the quality standards for xianghe suppository].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901

• [Protective effect of berberine on isolated perfused heart in heart failure].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010901

• Determination of berberine and strychnine in medicinal plants and herbal preparations by pressurized liquid extraction with capillary zone electrophoresis.

  Electrophoresis 20010801

• Chemiluminescence flow sensor for berberine with immobilized reagents.

  Bioorganic & medicinal chemistry 20010701

• High-performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal.

  Journal of pharmaceutical sciences 20010701

• In vitro cytotoxicity of the protoberberine-type alkaloids.

  Journal of natural products 20010701

• HWY-289, a novel semi-synthetic protoberberine derivative with multiple target sites in Candida albicans.

  The Journal of antimicrobial chemotherapy 20010501

• Inhibition of chemical carcinogenesis by berberine in rats and mice.

  The Journal of pharmacy and pharmacology 20010501

• Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats.

  Pharmacology & toxicology 20010501

• Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.

  Cancer letters 20010410

• Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor.

  Neurochemistry international 20010401

• Synthesis of glycosylated porphyrins as neutral ionophores for a berberine-sensitive electrode.

  Fresenius' journal of analytical chemistry 20010301

• Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c.

  Bioscience, biotechnology, and biochemistry 20010201

• Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine.

  Farmaco (Societa chimica italiana : 1989) 20010101

• Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.

  Cell biology and toxicology 20010101

• Cardiovascular actions of berberine.

  Cardiovascular drug reviews 20010101

• Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.

  Acta pharmacologica Sinica 20010101

• Effects of berberine on intracellular free calcium in smooth muscle cells of Guinea pig colon.

  Digestion 20010101

• [Berberine Hydrochloride Reference Standard (Control 001) of National Institute of Health Sciences].

  Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20010101

• Antimicrobial activity of 9-O-acyl- and 9-O-benzoyl-substituted berberrubines.

  Planta medica 20000501

• Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis-electrospray ion trap mass spectrometry.

  Journal of chromatography. A 20000114

• Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans.

  The Journal of antimicrobial chemotherapy 19990501

• The effect of Kampo formulae on bone resorption in vitro and in vivo. I. Active constituents of Tsu-kan-gan.

  Biological & pharmaceutical bulletin 19981201

• Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.

  Journal of natural products 19981001

• Screening of compounds for antimicrosporidial activity in vitro.

  Folia parasitologica 19980101

• Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase.

  Anticancer research 19980101

• Effect of long-term administration of berberine on scopolamine-induced amnesia in rats.

  Japanese journal of pharmacology 19970701

• HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.

  Biochemical and biophysical research communications 19920529

• Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

  Journal of natural products 19910101

• Screening for new compounds with antiherpes activity.

  Antiviral research 19841001