21187-98-4 | 1-[(4-methylbenzene)sulfonyl]-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$15.00	$10.00
1g	97%	in stock	$18.00	$12.00
5g	97%	in stock	$22.00	$15.00
25g	97%	in stock	$49.00	$34.00
100g	97%	in stock	$121.00	$85.00
500g	97%	in stock	$479.00	$335.00

Description

• Catalog Number: AI44857
• Chemical Name: 1-[(4-methylbenzene)sulfonyl]-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
• CAS Number: 21187-98-4
• Molecular Formula: C15H21N3O3S
• Molecular Weight: 323.4105
• MDL Number: MFCD00409893
• SMILES: O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CC2C(C1)CCC2
• NSC Number: 758673

Computed Properties

• Complexity: 497
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 2
• XLogP3: 1.5

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• Insulin releasing and alpha-glucosidase inhibitory activity of ethyl acetate fraction of Acorus calamus in vitro and in vivo.

  Journal of ethnopharmacology 20100302

• CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes.

  Diabetes 20100301

• Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.

  Diabetes care 20100301

• Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation.

  Journal of thrombosis and haemostasis : JTH 20100301

• Comparison of insulin sensitivity, glucose sensitivity, and first phase insulin secretion in patients treated with repaglinide or gliclazide.

  Archives of pharmacal research 20100301

• Cardioprotection and ageing.

  Korean journal of anesthesiology 20100301

• Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.

  Arquivos brasileiros de endocrinologia e metabologia 20100301

• A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study.

  Diabetic medicine : a journal of the British Diabetic Association 20100301

• Evaluation of different tests based on observations for external model evaluation of population analyses.

  Journal of pharmacokinetics and pharmacodynamics 20100201

• Event rates, hospital utilization, and costs associated with major complications of diabetes: a multicountry comparative analysis.

  PLoS medicine 20100201

• Regulation of glucose control in people with type 2 diabetes: a review and consensus.

  Korean diabetes journal 20100201

• The devil is in the detail - a multifactorial intervention to reduce blood pressure in co-existing diabetes and chronic kidney disease: a single blind, randomized controlled trial.

  BMC family practice 20100101

• Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure.

  PloS one 20100101

• Evaluation of efficacy and tolerability of gliclazide and metformin combination: a multicentric study in patients with type 2 diabetes mellitus uncontrolled on monotherapy with sulfonylurea or metformin.

  American journal of therapeutics 20100101

• Statin-associated weakness in myasthenia gravis: a case report.

  Journal of medical case reports 20100101

• Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.

  Mediators of inflammation 20100101

• Present status of sulfonylurea treatment for type 2 diabetes in Japan: second report of a cross-sectional survey of 15,652 patients.

  Endocrine journal 20100101

• JinQi-Jiangtang tablet, a Chinese patent medicine, for pre-diabetes: a randomized controlled trial.

  Trials 20100101

• [The effects of early intensive therapy on islet beta cell function and long-term glycemia control in newly diagnosed type 2 diabetic patients with different fasting plasma glucose levels.].

  Zhonghua nei ke za zhi 20100101

• Acute occlusion of the celiac axis and its branches with perforation of gastric fundus and splenic infarction, findings on spiral computed tomography: a case report.

  Cases journal 20100101

• Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk.

  Vascular health and risk management 20100101

• The value of episodic, intensive blood glucose monitoring in non-insulin treated persons with Type 2 Diabetes: design of the Structured Testing Program (STeP) study, a cluster-randomised, clinical trial [NCT00674986].

  BMC family practice 20100101

• Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society.

  Diabetology & metabolic syndrome 20100101

• A supercritical fluid chromatography/tandem mass spectrometry method for the simultaneous quantification of metformin and gliclazide in human plasma.

  Indian journal of pharmaceutical sciences 20100101

• Effect of Agaricus blazei Murill on the pulmonary tissue of animals with streptozotocin-induced diabetes.

  Experimental diabetes research 20100101

• Gene activation regresses atherosclerosis, promotes health, and enhances longevity.

  Lipids in health and disease 20100101

• Bone events and evolution of biologic markers in Gaucher disease before and during treatment.

  Arthritis research & therapy 20100101

• Association of hypoglycemic symptoms with patients' rating of their health-related quality of life state: a cross sectional study.

  Health and quality of life outcomes 20100101

• Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study.

  Cardiovascular diabetology 20100101

• Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors.

  Cardiovascular diabetology 20100101

• [Dynamics of structural-functional parameters of cardiovascular system during use of complex therapy of women with type 2 diabetes mellitus].

  Kardiologiia 20100101

• Validated high performance thin layer chromatographic determination and content uniformity test for rosiglitazone in tablets.

  Indian journal of pharmaceutical sciences 20100101

• Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention--a retrospective nationwide cohort study.

  Cardiovascular diabetology 20100101

• A prospective study of dietary selenium intake and risk of type 2 diabetes.

  BMC public health 20100101

• Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.

  Vascular health and risk management 20100101

• Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review.

  Vascular health and risk management 20100101

• [Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus].

  Terapevticheskii arkhiv 20100101

• Prolonged use of ertapenem to treat infected diabetic foot ulcers.

  Case reports in medicine 20100101

• Aqueous extract of garcinia indica choisy restores glutathione in type 2 diabetic rats.

  Journal of young pharmacists : JYP 20100101

• Pharmacotherapy-Based Problems in the Management of Diabetes Mellitus: Needs Much More to be Done!

  Journal of young pharmacists : JYP 20100101

• Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study.

  Cardiovascular diabetology 20100101

• Permeability evaluation through chitosan membranes using taguchi design.

  Scientia pharmaceutica 20100101

• Drug-drug Interaction between Pravastatin and Gemfibrozil (Antihyperlipidemic) with Gliclazide (Antidiabetic) in Rats.

  Journal of young pharmacists : JYP 20100101

• Efficacy of self-monitoring of blood glucose in patients with type 2 diabetes mellitus managed without insulin: a systematic review and meta-analysis.

  Open medicine : a peer-reviewed, independent, open-access journal 20100101

• Moyamoya syndrome in a known case of pulmonary tuberculosis.

  Journal of neurosciences in rural practice 20100101

• Protective role of glibenclamide against nicotinamide-streptozotocin induced nuclear damage in diabetic Wistar rats.

  Journal of pharmacology & pharmacotherapeutics 20100101

• Sulphonylureas and cancer: a case-control study.

  Acta diabetologica 20091201

• Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS.

  Biomedical chromatography : BMC 20091201

• Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091201

• Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis.

  European journal of clinical pharmacology 20091201

• Glibenclamide-related excess in total and cardiovascular mortality risks: data from large Ukrainian observational cohort study.

  Diabetes research and clinical practice 20091201

• Pharmacokinetics and bioequivalence evaluation of gliclazide/metformin combination tablet and equivalent doses of gliclazide and metformin in healthy Korean subjects.

  International journal of clinical pharmacology and therapeutics 20091201

• Recent cardiovascular trials: what are the drivers of benefit and adverse effect?

  Journal of diabetes 20091201

• Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.

  European journal of pharmacology 20091110

• Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.

  The Journal of clinical investigation 20091102

• Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial.

  Diabetes care 20091101

• Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.

  Diabetologia 20091101

• Self-monitoring of blood glucose as part of the integral care of type 2 diabetes.

  Diabetes care 20091101

• Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No.

  Diabetes care 20091101

• Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes.

  Diabetes care 20091101

• A summary of the ADVANCE Trial.

  Diabetes care 20091101

• Severe neuroglycopaenia secondary to severe hypoglycaemia from serendipitous overdose of gliclazide without adrenergic or autonomic response.

  Diabetic medicine : a journal of the British Diabetic Association 20091101

• Effect of gliclazide immobilization into layered double hydroxide on drug release.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20091001

• Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

  Diabetes 20091001

• Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan.

  International journal of clinical practice 20091001

• Trace analysis of glyclazide in human plasma at microscale level by mass spectrometry.

  Journal of separation science 20091001

• Second-generation sulfonylureas preserve inhibition of mitochondrial permeability transition by the mitochondrial K+(ATP) opener nicorandil in experimental myocardial infarction.

  Shock (Augusta, Ga.) 20090901

• Sulfonylureas and prognosis after myocardial infarction in patients with diabetes: a population-based follow-up study.

  Diabetes/metabolism research and reviews 20090901

• Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide.

  Diabetes & metabolism 20090901

• Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial.

  International journal of clinical practice 20090901

• Long-term effects of rosiglitazone on the progressive decline in renal function in patients with type 2 diabetes.

  The Korean journal of internal medicine 20090901

• The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens.

  International journal of molecular sciences 20090901

• D-pinitol attenuates the impaired activities of hepatic key enzymes in carbohydrate metabolism of streptozotocin-induced diabetic rats.

  General physiology and biophysics 20090901

• Sulphonylurea physicochemical-pharmacokinetic relationships in the pancreas and liver.

  Journal of pharmaceutical sciences 20090801

• Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats.

  Journal of ethnopharmacology 20090730

• Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.

  Bioorganic & medicinal chemistry 20090715

• Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.

  British journal of cancer 20090707

• Pioglitazone-induced acute rhabdomyolysis.

  Diabetes care 20090701

• A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes.

  Journal of clinical biochemistry and nutrition 20090701

• Synthesis and blood glucose lowering effect of novel pyridazinone substituted benzenesulfonylurea derivatives.

  European journal of medicinal chemistry 20090601

• The behavior of Gliclazide in solution and in the solid state: a case of organic compound presenting a solid-solution structure.

  Magnetic resonance in chemistry : MRC 20090601

• Physicochemical properties of solid dispersions of gliclazide in polyvinylpyrrolidone K90.

  AAPS PharmSciTech 20090601

• Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats.

  Metabolism: clinical and experimental 20090601

• Genetic architecture of type 2 diabetes: recent progress and clinical implications.

  Diabetes care 20090601

• Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.

  Chemico-biological interactions 20090515

• Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant.

  Journal of chromatography. A 20090515

• The oral anti-diabetic agent, gliclazide, inhibits oxidized LDL-mediated LOX-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells.

  Atherosclerosis 20090501

• Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats.

  European journal of pharmacology 20090501

• Blood pressure and glucose control in subjects with diabetes: new analyses from ADVANCE.

  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 20090501

• In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats.

  Pakistan journal of biological sciences : PJBS 20090501

• [Features of insulin secretion and insulin resistance in newly diagnosed type 2 diabetes of different body mass indices].

  Zhonghua yi xue za zhi 20090428

• Overcome side identification in PPOP by making orifices on both layers.

  International journal of pharmaceutics 20090417

• Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes.

  Journal of internal medicine 20090401

• Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.

  Diabetes 20090401

• Study of the Effect of Panax Ginseng versus Gliclazide on Hyperglycaemia Induced by Dexamethasone in Experimental Animals.

  Sultan Qaboos University medical journal 20090401

• Applying the Taguchi design for optimized formulation of sustained release gliclazide chitosan beads: an in vitro/in vivo study.

  AAPS PharmSciTech 20090301

• Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.

  Metabolism: clinical and experimental 20090301

• Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions.

  Acta pharmaceutica (Zagreb, Croatia) 20090301

• The metabolism of CYP2C9 and CYP2C19 for gliclazide by homology modeling and docking study.

  European journal of medicinal chemistry 20090201

• Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.

  Diabetes 20090201

• Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

  Diabetes 20090201

• Unexplained severe hypoglycaemia in hospital: a difficult diagnostic challenge.

  British journal of clinical pharmacology 20090201

• Treatment of HNF1-alpha MODY with the DPP-4 inhibitor Sitagliptin(1).

  Diabetic medicine : a journal of the British Diabetic Association 20090201

• Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet.

  Physiological research 20090101

• Normal insulin response to short-term intense exercise is abolished in Type 2 diabetic patients treated with gliclazide.

  Journal of diabetes and its complications 20090101

• Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.

  European journal of medicinal chemistry 20090101

• Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes.

  Diabetes care 20090101

• Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy.

  The Annals of pharmacotherapy 20090101

• Competition between COX-2 inhibitors and some other drugs for binding sites on human serum albumin.

  Drug metabolism and drug interactions 20090101

• DreamTel; Diabetes risk evaluation and management tele-monitoring study protocol.

  BMC endocrine disorders 20090101

• Redefining the role of thiazolidinediones in the management of type 2 diabetes.

  Vascular health and risk management 20090101

• Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20090101

• [Effect of early insulin therapy on nuclear factor-kappaB inflammatory pathway in liver of diabetic rat].

  Zhonghua nei ke za zhi 20090101

• Factors associated with results and conclusions of trials of thiazolidinediones.

  PloS one 20090101

• Co-solvent solubilization of some poorly-soluble antidiabetic drugs.

  Pharmaceutical development and technology 20090101

• Hypoglycemic herbs and their action mechanisms.

  Chinese medicine 20090101

• Rosiglitazone and myocardial infarction in patients previously prescribed metformin.

  PloS one 20090101

• Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.

  Molecular vision 20090101

• Interactions between herbal medicines and prescribed drugs: an updated systematic review.

  Drugs 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models.

  Diabetology & metabolic syndrome 20090101

• Revisiting clinical trials on glycemic control and cardiovascular risk.

  Diabetology & metabolic syndrome 20090101

• Fear of hypoglycaemia: defining a minimum clinically important difference in patients with type 2 diabetes.

  Health and quality of life outcomes 20090101

• Cardiotoxicity of verapamil in renal failure: a case report and review of the literature.

  Cases journal 20090101

• Persistent orocutaneous and anal fistulae induced by nicorandil: a case report.

  Journal of medical case reports 20090101

• Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

  BMJ (Clinical research ed.) 20090101

• Idiopathic pulmonary fibrosis associated with pulmonary vein thrombosis: a case report.

  Cases journal 20090101

• Dissolution enhancement of gliclazide using pH change approach in presence of twelve stabilizers with various physico-chemical properties.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

• [Diabetic edematous maculopathy associated with rosiglitazone treatment: report of a case].

  Bulletin de la Societe belge d'ophtalmologie 20090101

• Long-Term Alendronate Use Not without Consequences?

  International journal of rheumatology 20090101

• Implication of enterohepatic re-circulation on single dose bioequivalence evaluation of two brands of clonidine hydrochloride tablets in healthy human volunteers.

  Indian journal of pharmaceutical sciences 20090101

• Risk management in the treatment of type 2 diabetes with pioglitazone.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

• Self-monitoring of blood glucose in noninsulin-treated type 2 diabetes: an overview.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

• Setting-up nurse-led pilot clinics for the management of non-communicable diseases at primary health care level in resource-limited settings of Africa.

  The Pan African medical journal 20090101

• Short insulin tolerance test can determine the effects of thiazolidinediones treatment in type 2 diabetes.

  Yonsei medical journal 20081231

• [Effects of early insulin therapy on nuclear factor kappaB pathway in skeletal muscle of diabetes: experiment with rats].

  Zhonghua yi xue za zhi 20081216

• The efficacy of self-monitoring of blood glucose in the management of patients with type 2 diabetes treated with a gliclazide modified release-based regimen. A multicentre, randomized, parallel-group, 6-month evaluation (DINAMIC 1 study).

  Diabetes, obesity & metabolism 20081201

• Additive interaction of hyperglycemia and albuminuria on risk of ischemic stroke in type 2 diabetes: Hong Kong Diabetes Registry.

  Diabetes care 20081201

• In vitro and in vivo evaluation of a novel push-pull osmotic pump with orifices on both side surfaces.

  Drug development and industrial pharmacy 20081201

• Risk of coronary artery disease associated with initial sulphonylurea treatment of patients with type 2 diabetes: a matched case-control study.

  Diabetes research and clinical practice 20081201

• Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes.

  Vascular health and risk management 20081201

• Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib.

  British journal of cancer 20081104

• Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

  Diabetes care 20081101

• Hyperglycaemia secondary to mirtazapine therapy in a 37-year-old man.

  The Australian and New Zealand journal of psychiatry 20081101

• Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus.

  Journal of clinical biochemistry and nutrition 20081101

• Severe hyponatremia due to rosiglitazone use in an elderly woman with diabetes mellitus: a rare cause of syndrome of inappropriate antidiuretic hormone secretion.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081101

• Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.

  Diabetes care 20081001

• Comparison of gliclazide with insulin as initial treatment modality in newly diagnosed type 2 diabetes.

  Diabetes technology & therapeutics 20081001

• No need for the needle (at first).

  Diabetes care 20081001

• optimization of extended zero-order release gliclazide tablets using D-optimal mixture design.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081001

• Reversible binding of antidiabetic drugs, repaglinide and gliclazide, with human serum albumin.

  Chemical biology & drug design 20081001

• Euscaphic acid, a new hypoglycemic natural product from Folium Eriobotryae.

  Die Pharmazie 20081001

• Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

  Indian journal of pharmacology 20081001

• Clinical pharmacology.

  Indian journal of pharmacology 20081001

• Effect of early insulin therapy on nuclear factor kappaB and cytokine gene expressions in the liver and skeletal muscle of high-fat diet, streptozotocin-treated diabetic rats.

  Acta diabetologica 20080901

• Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content.

  Diabetes 20080901

• Glycemic control in diabetes: a tale of three studies.

  Diabetes care 20080901

• Daily blood glucose profiles of glibenclamide and gliclazide taken once or twice daily in elderly type 2 diabetic patients.

  Geriatrics & gerontology international 20080901

• Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome.

  Diabetes care 20080801

• Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6.

  Metabolism: clinical and experimental 20080801

• The effect of aqueous extract of Embelia ribes Burm on serum homocysteine, lipids and oxidative enzymes in methionine induced hyperhomocysteinemia.

  Indian journal of pharmacology 20080801

• Effects of sulfonylurea drugs on adiponectin production from 3T3-L1 adipocytes: implication of different mechanism from pioglitazone.

  Diabetes research and clinical practice 20080701

• Is Ramadan fasting safe in type 2 diabetic patients in view of the lack of significant effect of fasting on clinical and biochemical parameters, blood pressure, and glycemic control?

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20080701

• [A new method for safety monitoring of natural dietary supplements--quality profile].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20080701

• In vitro effect of gliclazide on DNA damage and repair in patients with type 2 diabetes mellitus (T2DM).

  Chemico-biological interactions 20080617

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.

  The New England journal of medicine 20080612

• Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000.

  AAPS PharmSciTech 20080601

• Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea.

  Translational research : the journal of laboratory and clinical medicine 20080601

• Comprehensive screening of acidic and neutral drugs in equine plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20080502

• Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus--an effect probably mediated by direct platelet PPARgamma activation.

  Atherosclerosis 20080401

• Extensions to the visual predictive check to facilitate model performance evaluation.

  Journal of pharmacokinetics and pharmacodynamics 20080401

• Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide.

  British journal of pharmacology 20080401

• Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin.

  Vascular health and risk management 20080401

• Erythromelalgia in a diabetic patient managed with gabapentin.

  Diabetes research and clinical practice 20080301

• The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.

  The Journal of clinical endocrinology and metabolism 20080301

• Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.

  Bioorganic & medicinal chemistry 20080301

• 2-year effects of pioglitazone add-on to sulfonylurea or metformin on oral glucose tolerance in patients with type 2 diabetes.

  Diabetes research and clinical practice 20080301

• Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.

  Acta diabetologica 20080301

• Hypoglycaemia in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20080301

• Spermicidal activity of sulfonylureas and meglitinide analogues: role of intrasperm Ca2+ elevation.

  The Journal of pharmacy and pharmacology 20080301

• Beneficial effects of rosiglitazone on novel cardiovascular risk factors in patients with Type 2 diabetes mellitus.

  Diabetic medicine : a journal of the British Diabetic Association 20080301

• Design and development of gliclazide mucoadhesive microcapsules: in vitro and in vivo evaluation.

  AAPS PharmSciTech 20080301

• A flexible nonlinear feedback system that captures diverse patterns of adaptation and rebound.

  The AAPS journal 20080301

• [Effects of Tangweian granule on 5-HT(2A)R in rat model with diabetic gastroparesis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

• Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics.

  Methods and findings in experimental and clinical pharmacology 20080301

• Antiglycation effect of gliclazide on in vitro AGE formation from glucose and methylglyoxal.

  Experimental biology and medicine (Maywood, N.J.) 20080201

• Dissection of the ascending thoracic aorta as a complication of percutaneous coronary intervention.

  Vascular health and risk management 20080201

• Ameliorating effects of sulfonylurea drugs on insulin resistance in Otsuka long-evans Tokushima Fatty rats.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080201

• Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

• Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects.

  Diabetes/metabolism research and reviews 20080101

• Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles.

  Naunyn-Schmiedeberg's archives of pharmacology 20080101

• Evaluation of gliclazide ability to attenuate the hyperglycaemic 'memory' induced by high glucose in isolated human endothelial cells.

  Diabetes/metabolism research and reviews 20080101

• Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

• Development of extended zero-order release gliclazide tablets by central composite design.

  Drug development and industrial pharmacy 20080101

• PPAR Signaling in Placental Development and Function.

  PPAR research 20080101

• Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study).

  Cardiovascular diabetology 20080101

• Diabetic control and atypical antipsychotics: a case report.

  Journal of medical case reports 20080101

• New onset diabetes complicated by haemolysis and rhabdomyolysis: a case report and review of the literature.

  Journal of medical case reports 20080101

• A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats.

  PloS one 20080101

• Primary Biliary Cirrhosis with a normal Alkaline Phosphatase: a case report.

  Cases journal 20080101

• Clinical drugs that interact with St. John's wort and implication in drug development.

  Current pharmaceutical design 20080101

• Evaluation of the cost effectiveness of exenatide versus insulin glargine in patients with sub-optimally controlled type 2 diabetes in the United Kingdom.

  Cardiovascular diabetology 20080101

• Cardioprotective effect of aqueous extract of Embelia ribes Burm fruits against isoproterenol-induced myocardial infarction in albino rats.

  Indian journal of experimental biology 20080101

• Performing meta-analysis with incomplete statistical information in clinical trials.

  BMC medical research methodology 20080101

• [Blood glucose control and cardiovascular disease in patients with type 2 diabetes. Results of ACCORD, ADVANCE and VA-Diabetes trials].

  Revue medicale de Liege 20080101

• Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats.

  European journal of drug metabolism and pharmacokinetics 20080101

• Influence of the semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy and diabetic rats.

  Pharmacological reports : PR 20080101

• The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.

  BMJ (Clinical research ed.) 20080101

• A diabetic patient presenting with stiff hand following fasciectomy for Dupuytren's contracture: A case report.

  Cases journal 20080101

• Vascular and renal benefits are additive using intensive blood pressure control and incremental glucose control in type 2 diabetic patients.

  Cardiovascular journal of Africa 20080101

• The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes.

  European journal of drug metabolism and pharmacokinetics 20080101

• Liquid chromatography--mass spectrometry method for the determination of gliclazide in human plasma and application to a pharmacokinetic study of gliclazide sustained release tablets.

  Arzneimittel-Forschung 20080101

• Peroxisome proliferator-activated receptors in diabetic nephropathy.

  PPAR research 20080101

• Rapid and Simple RPHPLC Method for the Estimation of Metformin in Rat Plasma.

  Indian journal of pharmaceutical sciences 20080101

• Simultaneous Estimation of Metformin Hydrochloride and Pioglitazone Hydrochloride by RPHPLC Method from Combined Tablet Dosage Form.

  Indian journal of pharmaceutical sciences 20080101

• Sulphonylureas induced vasorelaxation of mouse arteries.

  European journal of pharmacology 20071222

• Prediction of the metabolic interaction of nateglinide with other drugs based on in vitro studies.

  Drug metabolism and pharmacokinetics 20071201

• A review of nateglinide in the management of patients with type 2 diabetes.

  Vascular health and risk management 20071201

• Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes.

  Journal of biochemistry 20071101

• Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination.

  British journal of clinical pharmacology 20071001

• The influence of hydro-alcoholic media on hypromellose matrix systems.

  Drug development and industrial pharmacy 20071001

• Optimizing combination treatment in the management of type 2 diabetes.

  Vascular health and risk management 20071001

• A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.

  Vascular health and risk management 20071001

• [Advanced credit: patient enrolling and therapy initiation in the ADVANCE trial].

  Orvosi hetilap 20070930

• Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality.

  Diabetes/metabolism research and reviews 20070901

• 'Warm-up' phenomenon in diabetic patients with stable angina treated with diet or sulfonylureas.

  Coronary artery disease 20070901

• Long-term effects of pioglitazone versus gliclazide on hepatic and humoral coagulation factors in patients with type 2 diabetes.

  Diabetes & vascular disease research 20070901

• Effects of glibenclamide, glimepiride, and gliclazide on ischemic preconditioning in rat heart.

  Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20070901

• Controlling of systemic absorption of gliclazide through incorporation into alginate beads.

  International journal of pharmaceutics 20070816

• Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization.

  Free radical biology & medicine 20070801

• The effects of pioglitazone on cerebrovascular resistance in patients with type 2 diabetes mellitus.

  Metabolism: clinical and experimental 20070801

• Effect of immunosuppressive and other drugs on the cortisol-cortisone shuttle in human kidney and liver.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070801

• Effects of early use of pioglitazone in combination with metformin in patients with newly diagnosed type 2 diabetes.

  Current medical research and opinion 20070801

• PROactive 07: pioglitazone in the treatment of type 2 diabetes: results of the PROactive study.

  Vascular health and risk management 20070801

• Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes.

  Vascular health and risk management 20070801

• Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes.

  Diabetes research and clinical practice 20070701

• Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects.

  British journal of clinical pharmacology 20070701

• Gliclazide: pharmacokinetic-pharmacodynamic relationships in rats.

  Biopharmaceutics & drug disposition 20070701

• Nateglinide or gliclazide in combination with metformin for treatment of patients with type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone: 1-year trial results.

  Diabetes, obesity & metabolism 20070701

• In-vitro and in-vivo correlation for two gliclazide extended-release tablets.

  The Journal of pharmacy and pharmacology 20070701

• Effect of telmisartan in experimentally induced diabetetes mellitus in rats.

  International journal of health sciences 20070701

• Sepsis and meningitis due to Listeria monocytogenes.

  Yonsei medical journal 20070630

• Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

• Rosiglitazone RECORD study: glucose control outcomes at 18 months.

  Diabetic medicine : a journal of the British Diabetic Association 20070601

• New insights from ADVANCE.

  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 20070601

• Pioglitazone and sulfonylureas: effectively treating type 2 diabetes.

  International journal of clinical practice. Supplement 20070601

• Nateglinide quantification in rabbit plasma by HPLC: optimization and application to pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20070509

• Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina.

  Diabetologia 20070501

• Insulinoma causing hypoglycemia in a patient with type 2 diabetes.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20070501

• Induction of long-term glycemic control in type 2 diabetic patients using pioglitazone and metformin combination.

  The Journal of the Association of Physicians of India 20070501

• Mixture modeling for the detection of subpopulations in a pharmacokinetic/pharmacodynamic analysis.

  Journal of pharmacokinetics and pharmacodynamics 20070401

• Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose combination.

  Vascular health and risk management 20070401

• Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose.

  Diabetes/metabolism research and reviews 20070301

• A bioequivalence study of gliclazide based on quantification by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

  International journal of clinical pharmacology and therapeutics 20070301

• Comparison of the solubility and dissolution rate between gliclazide solid complex and its nanospheres.

  Drug development and industrial pharmacy 20070301

• High-performance liquid chromatography-electrospray ionization mass spectrometry determination of mitiglinide in human plasma and its pharmacokinetics.

  Journal of mass spectrometry : JMS 20070201

• Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20070201

• Dual aetiologies for hyperinsulinaemic hypoglycaemia in one patient.

  Hong Kong medical journal = Xianggang yi xue za zhi 20070201

• Preparation and in vitro/in vivo evaluation of gliclazide loaded Eudragit nanoparticles as a sustained release carriers.

  Drug development and industrial pharmacy 20070201

• Blood pressure normalization in a large population of hypertensive patients treated with perindopril/indapamide combination: results of the OPTIMAX trial.

  Vascular health and risk management 20070201

• Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients.

  American journal of physiology. Heart and circulatory physiology 20070101

• Beneficial effects of gliclazide modified release compared with glibenclamide on endothelial activation and low-grade inflammation in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20070101

• The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.

  Journal of alternative and complementary medicine (New York, N.Y.) 20070101

• Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial.

  Cardiovascular diabetology 20070101

• Impact of the short-term, intense exercise on postprandial glycemia in type 2 diabetic patients treated with gliclazide.

  Journal of diabetes and its complications 20070101

• Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes.

  Experimental diabetes research 20070101

• A cluster randomised controlled trial of educational prompts in diabetes care: study protocol.

  Implementation science : IS 20070101

• Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions.

  Cardiovascular diabetology 20070101

• In vivo and in vitro evaluation of a solid dispersion system of gliclazide:PEG 6000.

  PDA journal of pharmaceutical science and technology 20070101

• [Nail susceptibility to fungal infection in patients with type 1 and 2 diabetes under long term poor glycaemia control].

  Przeglad lekarski 20070101

• Pioglitazone and metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy.

  Core evidence 20070101

• A case of mistaken identity.

  Hong Kong medical journal = Xianggang yi xue za zhi 20061201

• Effect of Kaiyu Qingwei Jianji on the morphometry and residual strain distribution of small intestine in experimental diabetic rats.

  World journal of gastroenterology 20061128

• Association of gliclazide and left ventricular mass in type 2 diabetic patients.

  Diabetes research and clinical practice 20061101

• Contribution of solid-state properties to the aqueous solubility of drugs.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101

• Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.

  British journal of pharmacology 20061101

• Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression.

  Metabolism: clinical and experimental 20061101

• Effects of isopropyl palmitate on the skin permeation of drugs.

  Biological & pharmaceutical bulletin 20061101

• Application of monolithic column in quantification of gliclazide in human plasma by liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20061011

• Hair to document exposure to glibenclamide.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002

• Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay.

  Biomedical chromatography : BMC 20061001

• Influence of nicorandil on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits.

  Molecular and cellular biochemistry 20061001

• Effect of gliclazide modified release on adiponectin, interleukin-6, and tumor necrosis factor-alpha plasma levels in individuals with type 2 diabetes mellitus.

  Current medical research and opinion 20061001

• Drug-induced hypoglycaemia--new insight into an old problem.

  Hong Kong medical journal = Xianggang yi xue za zhi 20061001

• Effect of gliclazide on DNA damage in human peripheral blood lymphocytes and insulinoma mouse cells.

  Chemico-biological interactions 20060925

• Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.

  Pharmaceutical research 20060901

• Gliclazide treatment lowers serum ICAM-1 levels in poorly controlled type 2 diabetic patients.

  Diabetes & metabolism 20060901

• Clinical observation on effect of Kaixin capsule in treating 40 patients with diabetic myocardial ischemia.

  Chinese journal of integrative medicine 20060901

• Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient.

  Reviews in endocrine & metabolic disorders 20060901

• ADVANCE: breaking new ground in type 2 diabetes.

  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 20060801

• Antidiabetic activity of an ethanol extract obtained from the stem bark of Psidium guajava (Myrtaceae).

  Die Pharmazie 20060801

• [Rhabdomyolysis induced by fenofibrate monotherapy].

  La Revue de medecine interne 20060701

• Is it time to re-assess the role of gliclazide? Targeting insulin resistance in type 2 diabetes patients suboptimally controlled with insulin.

  Postgraduate medical journal 20060701

• Comparison of nateglinide and gliclazide in combination with metformin, for treatment of patients with Type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone.

  Diabetic medicine : a journal of the British Diabetic Association 20060701

• A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus.

  Journal of pharmacokinetics and pharmacodynamics 20060601

• Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation.

  Metabolism: clinical and experimental 20060601

• Gliclazide inhibits differentiation-associated biologic events in human monocyte-derived macrophages.

  Metabolism: clinical and experimental 20060601

• The development of non-insulin-dependent diabetes after total body irradiation and bone marrow transplantation in adolescence: a case report and literature review.

  Pediatric diabetes 20060601

• Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.

  Bioorganic & medicinal chemistry letters 20060515

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Effects of gliclazide beyond metabolic control.

  Metabolism: clinical and experimental 20060501

• Overcoming the hurdles to achieving glycemic control.

  Metabolism: clinical and experimental 20060501

• Managing hypertension in high-risk patients: lessons and promises from the STRATHE and ADVANCE trials.

  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 20060501

• Lymphocyte ecto-5'-nucleotidase in obese type 2 diabetic patients treated with gliclazide.

  Diabetes & metabolism 20060401

• Double-blind, randomized, multicentre study of the efficacy and safety of gliclazide-modified release in the treatment of Chinese type 2 diabetic patients.

  Diabetes, obesity & metabolism 20060301

• Comparison of glycaemic control over 1 year with pioglitazone or gliclazide in patients with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20060301

• Anti-diabetic and hypolipidemic effects of aqueous-extract from the flower of Inula japonica in alloxan-induced diabetic mice.

  Biological & pharmaceutical bulletin 20060301

• [Prevalence and consumption of medication in diabetes mellitus in Madrid (1996-2002)].

  Revista clinica espanola 20060301

• [Review of the interference between the most commonly prescribed drugs and clinical analyses at the Primary Health Care Centre of L'Hospitalet de Llobregat].

  Atencion primaria 20060227

• Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes.

  International journal of cardiology 20060215

• Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia/anti hyperglycaemia in normal/alloxan-induced diabetic rats.

  Molecular and cellular biochemistry 20060201

• Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat.

  Diabetes/metabolism research and reviews 20060101

• Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy.

  Diabetes/metabolism research and reviews 20060101

• Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.

  Journal of inflammation (London, England) 20060101

• Comparison of the antioxidant and vascular effects of gliclazide and glibenclamide in Type 2 diabetic patients: a randomized crossover study.

  Journal of diabetes and its complications 20060101

• Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin.

  Diabetes/metabolism research and reviews 20060101

• Development and validation of a new high-performance liquid chromatography method for the determination of gliclazide and repaglinide in pharmaceutical formulations.

  Journal of AOAC International 20060101

• A fixed-dose combination of pioglitazone and metformin: A promising alternative in metabolic control.

  Current medical research and opinion 20060101

• Single and multiple dose bioequivalence evaluation of two brands of gliclazide modified release tablets in healthy Chinese male volunteers.

  Arzneimittel-Forschung 20060101

• Severe combined hyperlipidaemia and retinal lipid infiltration in a patient with Type 2 diabetes mellitus.

  Lipids in health and disease 20060101

• The effectiveness of various doses of octreotide for sulfonylurea-induced hypoglycemia after overdose.

  Advances in therapy 20060101

• Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS).

  PPAR research 20060101

• Secondary sulfonylurea failure: comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.

  Diabetes research and clinical practice 20051201

• Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.

  The Journal of physiology 20051201

• Long-term effects on lipids and lipoproteins of pioglitazone versus gliclazide addition to metformin and pioglitazone versus metformin addition to sulphonylurea in the treatment of type 2 diabetes.

  Diabetologia 20051201

• Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?

  Vascular health and risk management 20051201

• The DIACOM study (effect of DosIng frequency of oral Antidiabetic agents on the COMpliance and biochemical control of type 2 diabetes).

  Diabetes, obesity & metabolism 20051101

• Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.

  Journal of mass spectrometry : JMS 20051101

• [The multi-level Meta analysis model combining individual level data with aggregative level data].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20051101

• Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetes.

  Diabetes research and clinical practice 20051001

• Synthesis and characterization of gliclazide complexes of magnesium, calcium, chromium, manganese, iron, nickel, copper, zinc and cadmium salts.

  Pakistan journal of pharmaceutical sciences 20051001

• [A multicenter clinic study of slow-release-gliclazide in type 2 diabetes mellitus].

  Zhonghua yi xue za zhi 20050928

• High-performance liquid chromatography with electrochemical detection for analysis of gliclazide in plasma.

  Journal of chromatography. A 20050923

• Determination of aminoheterocycle and azabicycle in gliclazide bulk by capillary zone electrophoresis with amperometric detection.

  Journal of pharmaceutical and biomedical analysis 20050915

• Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching.

  Clinical chemistry 20050901

• Management of diabetes during Ramadan.

  Diabetic medicine : a journal of the British Diabetic Association 20050901

• Gliclazide attenuates the intracellular Ca2+ changes induced in vitro by ischemia in the retinal slices of rats with streptozotocin-induced diabetes.

  Current eye research 20050901

• [Recent oral antidiabetic therapy].

  Revue medicale de Bruxelles 20050901

• Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide.

  Diabetic medicine : a journal of the British Diabetic Association 20050801

• Sulphonylureas in the management of type 2 diabetes during the fasting month of Ramadan.

  Journal of the Indian Medical Association 20050801

• Confusing tablets.

  Lancet (London, England) 20050701

• Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes.

  Diabetologia 20050601

• Pharmaceutical availability of gliclazide from selected matrix formulation tablets.

  Medical science monitor : international medical journal of experimental and clinical research 20050601

• Efficacy of glimepiride in Japanese type 2 diabetic subjects.

  Diabetes research and clinical practice 20050601

• The effect of gliclazide and glibenclamide on preconditioning of the human myocardium.

  European journal of pharmacology 20050516

• Late steroid withdrawal for renal transplant recipients on tacrolimus and MMF is safe.

  Transplantation proceedings 20050501

• [Controversial therapeutic strategies in the treatment of type 2 diabetes mellitus].

  MMW Fortschritte der Medizin 20050428

• A long-term comparison of pioglitazone and gliclazide in patients with Type 2 diabetes mellitus: a randomized, double-blind, parallel-group comparison trial.

  Diabetic medicine : a journal of the British Diabetic Association 20050401

• Evaluation of drug therapy and risk factors in diabetic hypertensives: a study of the quality of care provided in diabetic clinics in Bahrain.

  Journal of evaluation in clinical practice 20050401

• The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

• [54-year-old patient with type 2 diabetes mellitus and increased blood pressure values].

  Praxis 20050316

• Comparison of pioglitazone and gliclazide in sustaining glycemic control over 2 years in patients with type 2 diabetes.

  Diabetes care 20050301

• Pioglitazone elicits long-term improvements in insulin sensitivity in patients with type 2 diabetes: comparisons with gliclazide-based regimens.

  Diabetologia 20050301

• Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats.

  Journal of ethnopharmacology 20050227

• Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes.

  Diabetes care 20050201

• The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050201

• Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study.

  Diabetes/metabolism research and reviews 20050101

• Effect of repaglinide and gliclazide on postprandial control of endogenous glucose production.

  Metabolism: clinical and experimental 20050101

• Forearm vascular reactivity is differentially influenced by gliclazide and glibenclamide in chronically treated type 2 diabetic patients.

  Clinical physiology and functional imaging 20050101

• Gliclazide modified release.

  Drugs 20050101

• Bench-to-bedside review: Antidotal treatment of sulfonylurea-induced hypoglycaemia with octreotide.

  Critical care (London, England) 20050101

• Effect of I-deprenyl and gliclazide on oxidant stress/antioxidant status and dna damage in a diabetic rat model.

  Endocrine research 20050101

• Exubera(®) (inhaled insulin): an evidence-based review of its effectiveness in the management of diabetes.

  Core evidence 20050101

• Rational pharmacotherapy in the diabetic hypertension: analysis-prescribing patterns in a general hospital in Taiwan.

  Journal of clinical pharmacy and therapeutics 20041201

• Effect of aqueous extract of Cyamopsis tetragonoloba Linn. beans on blood glucose level in normal and alloxan-induced diabetic rats.

  Indian journal of experimental biology 20041201

• Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105

• Gliclazide modified release: results of a 2-year study in patients with type 2 diabetes.

  Diabetes, obesity & metabolism 20041101

• Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.

  Diabetologia 20041101

• Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.

  International journal of clinical practice 20041001

• [Therapy objectives and daily practice--to which extent are blood sugar target values accessible in daily practice?].

  Praxis 20040929

• Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.

  Biochemical pharmacology 20040901

• Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide.

  International journal of clinical practice 20040901

• Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats.

  Pharmacological research 20040801

• GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients.

  European journal of clinical investigation 20040801

• Efficacy and safety of once daily gliclazide (20 mg/day) compared with nateglinide.

  Endocrine journal 20040801

• [2-year data of large clinical comparative studies. Type 2 diabetes: lasting metabolic control with pioglitazone].

  MMW Fortschritte der Medizin 20040722

• Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy.

  Pharmacotherapy 20040701

• [The efficacy and safety of 30 mg slow-released-gliclazide in type 2 diabetes mellitus].

  Zhonghua nei ke za zhi 20040701

• Quantification of gliclazide by semi-micro high-performance liquid chromatography: application to a bioequivalence study of two formulations in healthy subjects.

  Journal of pharmaceutical and biomedical analysis 20040629

• Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression: inhibitory effect of antioxidants.

  Journal of leukocyte biology 20040601

• Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes.

  Diabetes research and clinical practice 20040601

• Normal pregnancy outcome following inadvertent exposure to rosiglitazone, gliclazide, and atorvastatin in a diabetic and hypertensive woman.

  Reproductive toxicology (Elmsford, N.Y.) 20040601

• The effect of deinsuring chlorpropamide on the prescribing of oral antihyperglycemics for Nova Scotia Seniors' Pharmacare beneficiaries.

  Pharmacotherapy 20040601

• Comparison of uptitration of gliclazide with the addition of rosiglitazone to gliclazide in patients with type 2 diabetes inadequately controlled on half-maximal doses of a sulphonylurea.

  Acta diabetologica 20040601

• Effects of thioacetamide on pancreatic islet B-cell function.

  Endocrine 20040601

• Octreotide treatment for sulfonylurea-induced hypoglycaemia.

  The Medical journal of Australia 20040517

• The effects of diet, sulfonylurea, and Repaglinide therapy on clinical and metabolic parameters in type 2 diabetic patients during Ramadan.

  Endocrine research 20040501

• [Effect of sanhuang jiangtang recipe on renin-angiotensin system in local myocardium in diabetic rats].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040401

• Gliclazide at a lower concentration than therapeutic dose increases the sensitivity of insulin secretion to glucose in perfused rat pancreas.

  Diabetes & metabolism 20040401

• [Long-term HbA1c stable. Insulin sensitizer keeps diabetes in check].

  MMW Fortschritte der Medizin 20040325

• Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1.

  Biochemical pharmacology 20040315

• Erosion induced controllable release of gliclazide encapsulated inside degradable polymeric particles.

  Macromolecular bioscience 20040315

• Signalling pathways involved in retinal endothelial cell proliferation induced by advanced glycation end products: inhibitory effect of gliclazide.

  Diabetes, obesity & metabolism 20040301

• NMDA receptor subunits 2A and 2B decrease and lipid peroxidation increase in the hippocampus of streptozotocin-diabetic rats: effects of insulin and gliclazide treatments.

  The International journal of neuroscience 20040301

• Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet.

  Kidney international 20040301

• Effect of antidiabetic medications on microalbuminuria in patients with type 2 diabetes.

  Metabolism: clinical and experimental 20040301

• Myocardial protection from either ischaemic preconditioning or nicorandil is not blocked by gliclazide.

  Cardiovascular drugs and therapy 20040301

• [Compliance and optimisation of oral antidiabetic therapy. A longitudinal study].

  Presse medicale (Paris, France : 1983) 20040214

• Phosphatidylinositol 3-kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle.

  Endocrinology 20040201

• Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.

  International journal of clinical practice 20040201

• Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.

  Diabetes care 20040101

• Protective actions of gliclazide on high insulin-enhanced neutrophil-endothelial cell interactions through inhibition of mitogen activated protein kinase and protein kinase C pathways.

  Microvascular research 20040101

• Spectrophotometric determination of gliclazide in pharmaceuticals and biological fluids through ternary complex formation with eosin and palladium (II).

  Farmaco (Societa chimica italiana : 1989) 20040101

• The antidiabetic agent, gliclazide, reduces high insulin-enhanced neutrophil-transendothelial migration through direct effects on the endothelium.

  Diabetes/metabolism research and reviews 20040101

• The role of sulphonylureas in the management of type 2 diabetes mellitus.

  Drugs 20040101

• Chinese herbal medicines for type 2 diabetes mellitus.

  The Cochrane database of systematic reviews 20040101

• NIDDM: new once-daily intervention for type 2 diabetes mellitus: Diaprel MR.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

• [A prospective randomized study of sulphonylureas therapeutic interchange in patients with type 2 diabetes mellitus].

  Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

• Pharmacokinetic differences of some generic tablet gliclazide 80 mg on Pakistani population.

  Pakistan journal of pharmaceutical sciences 20040101

• Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.

  Diabetic medicine : a journal of the British Diabetic Association 20031101

• Effects of rosiglitazone maleate when added to a sulfonylurea regimen in patients with type 2 diabetes mellitus and mild to moderate renal impairment: a post hoc analysis.

  Clinical therapeutics 20031101

• Genetic cause of hyperglycaemia and response to treatment in diabetes.

  Lancet (London, England) 20031018

• Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide.

  Clinical pharmacology and therapeutics 20031001

• Monotherapy of type 2 diabetes with once-daily gliclazide modified release in primary care.

  Diabetes research and clinical practice 20031001

• Risk of hypoglycaemia with oral antidiabetic agents in patients with Type 2 diabetes.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20031001

• [Medication of the month. Gliclazide modified release (Uni Diamicron)].

  Revue medicale de Liege 20031001

• Reflex epilepsy and non-ketotic hyperglycemia.

  Epileptic disorders : international epilepsy journal with videotape 20030901

• Benefits of gliclazide in the atherosclerotic process: decrease in monocyte adhesion to endothelial cells.

  Metabolism: clinical and experimental 20030801

• Gliclazide modified release: A critical review of pharmacodynamic, metabolic, and vasoprotective effects.

  Metabolism: clinical and experimental 20030801

• Bioequivalence study of generic gliclazide and Diamicron formulations in healthy Thai male volunteers.

  International journal of clinical pharmacology and therapeutics 20030701

• The application of the convective diffusion model and the film equilibrium model to surfactant-facilitated dissolution of gliclazide.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701

• Pharmacokinetic and pharmacodynamic characterization of gliclazide in healthy volunteers.

  Archives of pharmacal research 20030701

• Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels.

  British journal of pharmacology 20030601

• Comparison of the micro- and macro-vascular effects of glimepiride and gliclazide in metformin-treated patients with Type 2 diabetes: a double-blind, crossover study.

  British journal of clinical pharmacology 20030601

• Diabetes and vascular disease: a new international trial.

  Asian cardiovascular & thoracic annals 20030601

• Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available data in humans and clinical applications.

  Diabetes & metabolism 20030601

• Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.

  British journal of cancer 20030519

• Urinary PC-1 and N-acetyl-beta-D-glucosaminidase activity in patients with type 2 diabetes treated with metformin, gliclazide or glibenclamide.

  Annals of clinical biochemistry 20030501

• Study of the solubilization of gliclazide by aqueous micellar solutions.

  Journal of pharmaceutical sciences 20030401

• Gliclazide protects pancreatic beta-cells from damage by hydrogen peroxide.

  Biochemical and biophysical research communications 20030328

• A simple and sensitive HPLC method for determination of gliclazide in human serum.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030305

• Gliclazide as novel carrier in construction of PVC-based La(III)-selective membrane sensor.

  Talanta 20030301

• Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation.

  British journal of clinical pharmacology 20030201

• Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.

  Fundamental & clinical pharmacology 20030201

• Diabetes mellitus and weight control: differences of respiratory quotient in type 2 diabetic obese subjects receiving sulfonylureas and non-diabetic obese controls.

  Nutrition (Burbank, Los Angeles County, Calif.) 20030201

• Severe relapsing sulphonylurea-induced hypoglycaemia: a diagnostic and therapeutic challenge.

  Postgraduate medical journal 20030201

• The mechanisms of inhibitory actions of gliclazide on neutrophils-endothelial cells adhesion and surface expression of endothelial adhesion molecules mediated by a high glucose concentration.

  Journal of diabetes and its complications 20030101

• Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm.

  Clinical science (London, England : 1979) 20030101

• Effects of sulfonylureas on K(ATP) channel-dependent vasodilation.

  Journal of diabetes and its complications 20030101

• Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions.

  Journal of diabetes and its complications 20030101

• Monocyte adhesion in diabetic angiopathy: effects of free-radical scavenging.

  Journal of diabetes and its complications 20030101

• Diabetic endothelial dysfunction: effect of free radical scavenging in Type 2 diabetic patients.

  Journal of diabetes and its complications 20030101

• Monocyte matrix metalloproteinase production in Type 2 diabetes and controls--a cross sectional study.

  Cardiovascular diabetology 20030101

• Spectrofluorimetric and spectrophotometric determination of gliclazide in pharmaceuticals by derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole.

  Journal of AOAC International 20030101

• Addition of rosiglitazone to existing sulfonylurea treatment in chinese patients with type 2 diabetes and exposure to hepatitis B or C.

  Diabetes technology & therapeutics 20030101

• [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus].

  Yakushigaku zasshi 20030101

• In vitro availability of gliclazide in presence of antacids.

  Pakistan journal of pharmaceutical sciences 20030101

• Gliclazide increases insulin receptor tyrosine phosphorylation but not p38 phosphorylation in insulin-resistant skeletal muscle cells.

  The Journal of experimental biology 20021201

• Sulfonylurea stimulation of insulin secretion.

  Diabetes 20021201

• Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.

  Diabetes 20021201

• Gliclazide directly inhibits arginine-induced glucagon release.

  Diabetes 20021201

• Combination therapy of alpha-glucosidase inhibitor and a sulfonylurea compound prolongs the duration of good glycemic control.

  Metabolism: clinical and experimental 20021201

• Hypoglycaemic activity of Alpinia galanga rhizome and its extracts in rabbits.

  Fitoterapia 20021201

• [Molecular mechanisms of insulin secretion].

  Diabetes & metabolism 20021201

• High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology.

  Diabetes & metabolism 20021201

• Eudragit NE30D based metformin/gliclazide extended release tablets: formulation, characterisation and in vitro release studies.

  Chemical & pharmaceutical bulletin 20021101

• Effect of gliclazide on islet transplants.

  Transplantation proceedings 20021101

• Remodelling of zero-stress state of small intestine in streptozotocin-induced diabetic rats. Effect of gliclazide.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20021001

• Gliclazide improves anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20020901

• Gateways to Clinical Trials.

  Methods and findings in experimental and clinical pharmacology 20020901

• A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor.

  Analytical biochemistry 20020815

• Bioequivalence evaluation of two brands of gliclazide 80 mg tablets (Glyzide & Diamicron)--in healthy human volunteers.

  Biopharmaceutics & drug disposition 20020701

• Antiaggregatory activity of hypoglycaemic sulphonylureas.

  Diabetologia 20020701

• Oral hypoglycaemic agent failure.

  Journal of the Indian Medical Association 20020701

• Method development for analysis of gliclazide in human plasma by using high-performance liquid chromatography.

  Pakistan journal of pharmaceutical sciences 20020701

• Acute gliclazide administration enhances glucose and ketone body utilization in the perfused hind limb of normal and streptozotocin-diabetic rats.

  Life sciences 20020628

• Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615

• Effect of pioglitazone on blood proinsulin levels in patients with type 2 diabetes mellitus.

  Endocrine journal 20020601

• Complete bioavailability and lack of food-effect on pharmacokinetics of gliclazide 30 mg modified release in healthy volunteers.

  Biopharmaceutics & drug disposition 20020501

• Gliclazide-induced acute hepatitis with hypersensitivity features.

  Digestive diseases and sciences 20020501

• Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide.

  Diabetologia 20020501

• Studies on solubility and hypoglycemic activity of gliclazide beta-cyclodextrin-hydroxypropylmethylcellulose complexes.

  Die Pharmazie 20020301

• Adenosine triphosphate-sensitive potassium (K(ATP)) channel activity is coupled with insulin resistance in obesity and type 2 diabetes mellitus.

  Internal medicine (Tokyo, Japan) 20020201

• Family physicians' and general practitioners' approaches to drug management of diabetic hypertension in primary care.

  Journal of evaluation in clinical practice 20020201

• Does gliclazide stimulate first-phase, second-phase, or both phases of insulin release?

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020201

• New trends in the development of oral antidiabetic drugs.

  Current medicinal chemistry 20020101

• Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells: effect of antidiabetic medicines.

  Journal of diabetes and its complications 20020101

• Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs.

  Seminars in liver disease 20020101

• Gliclazide modified release.

  Drugs 20020101

• Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide.

  Journal of diabetes and its complications 20020101

• Trends in oral antihyperglycemic and insulin use in the Nova Scotia senior population (1993-1999).

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20020101

• Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats.

  International journal of experimental diabetes research 20020101

• Regulation of glucose transporter 1 expression by gliclazide in rat L6 myoblasts.

  Diabetes, nutrition & metabolism 20011201

• Increments in insulin sensitivity during intensive treatment are closely correlated with decrements in glucocorticoid receptor mRNA in skeletal muscle from patients with Type II diabetes.

  Clinical science (London, England : 1979) 20011101

• Prescribing patterns and therapeutic implications for diabetic hypertension in Bahrain.

  The Annals of pharmacotherapy 20011101

• Structural basis for the interference between nicorandil and sulfonylurea action.

  Diabetes 20011001

• Possible interaction between gliclazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia.

  British journal of clinical pharmacology 20011001

• Liver failure after long-term nucleoside antiretroviral therapy.

  Lancet (London, England) 20010901

• Study rationale and design of ADVANCE: action in diabetes and vascular disease--preterax and diamicron MR controlled evaluation.

  Diabetologia 20010901

• Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes.

  Diabetes 20010801

• Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells.

  Diabetologia 20010801

• Glibenclamide vs gliclazide in reducing oxidative stress in patients of noninsulin dependent diabetes mellitus--a double blind randomized study.

  The Journal of the Association of Physicians of India 20010801

• Gliclazide decreases vascular smooth muscle cell dysfunction induced by cell-mediated oxidized low-density lipoprotein.

  Metabolism: clinical and experimental 20010601

• Gliclazide mainly affects insulin secretion in second phase of type 2 diabetes mellitus.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010601

• ATP-Sensitive potassium channels modulate glucose transport in cultured human skeletal muscle cells.

  Endocrine journal 20010601

• [Effects of gliclazide on blood rheology of diabetes Wistar rat].

  Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010601

• Characteristics of pancreatic beta-cell secretion in Type 2 diabetic patients treated with gliclazide and glibenclamide.

  Diabetes research and clinical practice 20010501

• ION-pair liquid chromatography technique for the estimation of metformin in its multicomponent dosage forms.

  Journal of pharmaceutical and biomedical analysis 20010401

• Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia.

  Diabetes care 20010401

• 24-hour glycemic profile in type 2 diabetic patients treated with gliclazide modified release once daily.

  Diabetes & metabolism 20010401

• Effect of KAD-1229, a nonsulfonylurea hypoglycemic agent, on plasma glucose and insulin in streptozotocin-induced diabetic dogs.

  Pharmacology 20010201

• Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010101

• Comparison of acarbose and gliclazide as first-line agents in patients with type 2 diabetes.

  Current medical research and opinion 20010101

• Comparison of the effects of three sulfonylureas on in vivo insulin action.

  Arzneimittel-Forschung 20010101

• [Free radical scavenging activity of sulfonylureas: a clinical assessment of the effectiveness of gliclazide].

  Terapevticheskii arkhiv 20010101

• Repaglinide: a review of its therapeutic use in type 2 diabetes mellitus.

  Drugs 20010101

• Gliclazide-induced hepatitis, hemiplegia and dysphasia in a suicide attempt.

  Journal of pediatric endocrinology & metabolism : JPEM 20010101

• [Toxicological analysis in the dawn of the third millenium].

  Annales de biologie clinique 20010101

• [Recurrent toxic severe hypoglycemias].

  Annales de biologie clinique 20010101

• Determination of gliclazide in pharmaceutical preparations by capillary gas chromatography with cool on-column injection and elimination of the matrix effect.

  Journal of AOAC International 20010101

• [Antioxidant and anti-AGE therapeutics: evaluation and perspectives].

  Journal de la Societe de biologie 20010101

• Gliclazide-induced acute hepatitis.

  European journal of gastroenterology & hepatology 20000101

• Cardiovascular effects of conventional sulfonylureas and glimepiride.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 19960901

• Possible gliclazide-induced water retention with azotemia.

  Internal medicine (Tokyo, Japan) 19940301