213743-31-8 | 7-Cyclopentyl-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-ylamine

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$10.00	$7.00
5mg	99%	in stock	$29.00	$20.00

Description

• Catalog Number: AF38872
• Chemical Name: 7-Cyclopentyl-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-ylamine
• CAS Number: 213743-31-8
• Molecular Formula: C23H22N4O
• Molecular Weight: 370.447
• MDL Number: MFCD04974490
• SMILES: Nc1ncnc2c1c(cn2C1CCCC1)c1ccc(cc1)Oc1ccccc1

Computed Properties

• Complexity: 497
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 4.6

Literature

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.

  Protein science : a publication of the Protein Society 20100301

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

  Bioorganic & medicinal chemistry letters 20020617

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.

  Bioorganic & medicinal chemistry letters 20001002