213764-25-1 | Cyclopropylhydrazine hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$10.00	$7.00
1g	97%	in stock	$15.00	$11.00
5g	97%	in stock	$68.00	$48.00
10g	97%	in stock	$130.00	$91.00
25g	97%	in stock	$325.00	$228.00

Description

• Catalog Number: AB49609
• Chemical Name: Cyclopropylhydrazine hydrochloride
• CAS Number: 213764-25-1
• Molecular Formula: C3H9ClN2
• Molecular Weight: 108.57
• MDL Number: MFCD16658753
• SMILES: NNC1CC1.Cl

Computed Properties

• Complexity: 31.9
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1

Upstream Synthesis Route

The upstream synthesis route of cyclopropylhydrazine hydrochloride starts with the formation of cyclopropyl bromide. This is typically achieved by treating cyclopropyl alcohol with hydrobromic acid (HBr), resulting in a substitution reaction that replaces the hydroxyl group with a bromine atom, creating the alkyl bromide intermediate.

The next step involves the generation of hydrazine. Industrially, this is often done through the Raschig process, which involves the oxidation of ammonia with sodium hypochlorite in the presence of a gelatin or glue promoter. Alternatively, the Olin Raschig process can be used, where ammonia reacts with sodium hypochlorite at higher temperatures without a promoter, to give chloramine, which is subsequently reacted with ammonia to form hydrazine.

Once hydrazine is available, it can be reacted with cyclopropyl bromide to form cyclopropylhydrazine via nucleophilic substitution of the bromide with the nitrogen of the hydrazine molecule. This reaction usually requires the presence of a base to deprotonate the hydrazine, making it a better nucleophile.

Finally, the free base cyclopropylhydrazine is treated with hydrochloric acid to yield the cyclopropylhydrazine hydrochloride salt. The formation of the hydrochloride salt enhances the solubility of cyclopropylhydrazine in water and often improves its stability, making it easier to handle and store.