2140-79-6 | 2'-O-Methyladenosine

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$23.00	$16.00
250mg	98%	in stock	$32.00	$22.00
1g	98%	in stock	$42.00	$29.00
5g	98%	in stock	$103.00	$72.00
10g	98%	in stock	$155.00	$108.00
100g	98%	in stock	$1,209.00	$846.00

Description

• Catalog Number: AB44201
• Chemical Name: 2'-O-Methyladenosine
• CAS Number: 2140-79-6
• Molecular Formula: C11H15N5O4
• Molecular Weight: 281.2679
• MDL Number: MFCD00056002
• SMILES: CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N)CO

Computed Properties

• Complexity: 349
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -0.5

Upstream Synthesis Route

2'-O-Methyladenosine is a pivotal compound in chemical synthesis, commonly employed in the modification of RNA molecules. This modification serves to enhance the stability and efficiency of RNA, making it a valuable tool in molecular biology research and therapeutic applications. By incorporating 2'-O-Methyladenosine into RNA sequences, researchers can manipulate the structure and function of RNA, allowing for targeted studies of gene expression and interactions within cellular processes. Furthermore, the unique properties of 2'-O-Methyladenosine make it highly suitable for studying RNA-protein interactions and RNA folding dynamics, providing valuable insights into the mechanisms underlying biological functions. Overall, the strategic use of 2'-O-Methyladenosine in chemical synthesis offers a versatile approach to RNA modification, showcasing its potential for advancing diverse fields of scientific inquiry.

Literature

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  PLoS pathogens 20120401

• Metal Ion Chelates as Surrogates of Nucleobases for the Recognition of Nucleic Acid Sequences: The Pd(2+) Complex of 2,6-Bis(3,5-dimethylpyrazol-1-yl)purine Riboside.

  Journal of nucleic acids 20120101

• Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

  BMC plant biology 20100101

• Modifications in small interfering RNA that separate immunostimulation from RNA interference.

  Journal of immunology (Baltimore, Md. : 1950) 20080301

• RNA analysis by MEKC with LIF detection.

  Electrophoresis 20071101

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  Bioorganic & medicinal chemistry 20070815

• Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

  Journal of medicinal chemistry 20070809

• Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity.

  Virology journal 20050101

• Acidity of secondary hydroxyls in ATP and adenosine analogues and the question of a 2',3'-hydrogen bond in ribonucleosides.

  Journal of the American Chemical Society 20041117

• Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

  Journal of medicinal chemistry 20040422

• Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.

  RNA (New York, N.Y.) 20030801

• The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interaction.

  Journal of molecular biology 20021122

• Antiviral activity of O'-methylated derivatives of adenine arabinoside.

  Biochemical pharmacology 19770415