215923-54-9 | (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone

Packsize	Purity	Availability	Price	Discounted Price
10mg	98+%	in stock	$42.00	$30.00
25mg	98+%	in stock	$71.00	$50.00
50mg	98+%	in stock	$100.00	$70.00

Description

• Catalog Number: AF32666
• Chemical Name: (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone
• CAS Number: 215923-54-9
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.2897
• MDL Number: MFCD01860868
• SMILES: O=C(c1ccc2c(c1)OCCO2)N1CCCCC1

Computed Properties

• Complexity: 301
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: 1.1

Literature

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  The European journal of neuroscience 20110101

• AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell.

  Neurochemistry international 20101101

• Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

  Journal of medicinal chemistry 20101028

• Effects of agents targeting glutamatergic systems on marble-burying behavior.

  Neuroscience letters 20100303

• Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats.

  Behavioural brain research 20100211

• Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations.

  The Journal of pharmacology and experimental therapeutics 20091201

• Memory and the NMDA receptors.

  The New England journal of medicine 20090716

• Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

  PLoS biology 20090201

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  Respiratory physiology & neurobiology 20081210

• Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081022

• Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.

  European journal of pharmacology 20071201

• Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20071003

• The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

• Ampakines alleviate respiratory depression in rats.

  American journal of respiratory and critical care medicine 20061215

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Glutamate-based therapeutic approaches: ampakines.

  Current opinion in pharmacology 20060201

• Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.

  The Journal of pharmacology and experimental therapeutics 20050401

• Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators.

  Journal of neurochemistry 20050201

• Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus.

  Neuroscience 20040101

• Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization.

  Molecular pharmacology 20030701

• Dynorphin A toxicity in striatal neurons via an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism.

  Neuroscience 20030101

• Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion.

  Neuroscience 20030101

• Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

  The Journal of pharmacology and experimental therapeutics 20021201

• A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide.

  Nuclear medicine and biology 20021101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Survival signaling and selective neuroprotection through glutamatergic transmission.

  Experimental neurology 20020301

• Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

  Neuropharmacology 20011101