22494-42-4 | 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$22.00	$15.00
10g	98%	in stock	$28.00	$19.00
25g	98%	in stock	$58.00	$40.00
100g	98%	in stock	$200.00	$140.00

Description

• Catalog Number: AB72833
• Chemical Name: 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid
• CAS Number: 22494-42-4
• Molecular Formula: C13H8F2O3
• Molecular Weight: 250.19762640000002
• MDL Number: MFCD00057834
• SMILES: Fc1ccc(c(c1)F)c1ccc(c(c1)C(=O)O)O
• NSC Number: 756728

Computed Properties

• Complexity: 311
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 4.4

Literature

• Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

  Chemical research in toxicology 20150518

• Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models.

  Chemico-biological interactions 20150225

• Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.

  Toxicology in vitro : an international journal published in association with BIBRA 20141001

• Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking.

  Journal of molecular modeling 20121201

• 2D solid-state NMR analysis of inclusion in drug-cyclodextrin complexes.

  Molecular pharmaceutics 20121105

• Attempts at suppression of amyloidogenesis in a mouse model by a variety of anti-inflammatory agents.

  Autoimmunity reviews 20121101

• Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.

  European journal of medicinal chemistry 20120701

• The Diflunisal Trial: study accrual and drug tolerance.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20120601

• Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

  The Cochrane database of systematic reviews 20120215

• Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.

  European journal of medicinal chemistry 20120201

• Diagnosis and treatment of acute ankle injuries: development of an evidence-based algorithm.

  Orthopedic reviews 20120102

• Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: 'in vivo' evidence from FAP mice models.

  PloS one 20120101

• Bach adsorption study for the extraction of silver ions by hydrazone compounds from aqueous solution.

  TheScientificWorldJournal 20120101

• Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.

  PloS one 20120101

• Preclinical development of siRNA therapeutics for AL amyloidosis.

  Gene therapy 20111201

• Non-steroidal anti-inflammatory drug diflunisal interacting with Cu(II). Structure and biological features.

  Journal of inorganic biochemistry 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.

  Science translational medicine 20110824

• Renal amyloidosis in children.

  Pediatric nephrology (Berlin, Germany) 20110801

• Lanthanide-based time-resolved luminescence immunoassays.

  Analytical and bioanalytical chemistry 20110701

• The diflunisal trial: update on study drug tolerance and disease progression.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20110601

• Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.

  Journal of structural biology 20110401

• Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor.

  Drug metabolism and disposition: the biological fate of chemicals 20110301

• Two-step stacking in capillary zone electrophoresis featuring sweeping and micelle to solvent stacking: II. Organic anions.

  Journal of chromatography. A 20110218

• A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.

  Bioorganic & medicinal chemistry 20110215

• Lyprinol-is it a useful anti-inflammatory agent?

  Evidence-based complementary and alternative medicine : eCAM 20110101

• A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20110101

• Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations.

  Chemistry Central journal 20110101

• Transfer kinetics from colloidal drug carriers and liposomes to biomembrane models: DSC studies.

  Journal of pharmacy & bioallied sciences 20110101

• Sickle cell disease.

  BMJ clinical evidence 20110101

• The inhibitory effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activities of mushroom tyrosinase.

  International journal of molecular sciences 20110101

• Single dose oral analgesics for acute postoperative pain in adults.

  The Cochrane database of systematic reviews 20110101

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Drug structure-transport relationships.

  Journal of pharmacokinetics and pharmacodynamics 20101201

• Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

  Healthcare informatics research 20101201

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

  Bioorganic & medicinal chemistry 20101101

• [Familial amyloid polyneuropathy: diflunisal].

  Rinsho shinkeigaku = Clinical neurology 20101101

• Rapid simultaneous determination of four non-steroidal anti-inflammatory drugs by means of derivative nonlinear variable-angle synchronous fluorescence spectrometry.

  Applied spectroscopy 20100801

• Transthyretin-related familial amyloidotic polyneuropathy-Progress in Kumamoto, Japan (1967-2010)-.

  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100721

• Nonsteroidal anti-inflammatory therapy and recurrent acute anterior uveitis.

  Ocular immunology and inflammation 20100401

• Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori.

  Dalton transactions (Cambridge, England : 2003) 20100321

• The Open AUC Project.

  European biophysics journal : EBJ 20100201

• Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC.

  Journal of chromatographic science 20100201

• Evaluation of the drug-polymer interaction in calcium alginate beads containing diflunisal.

  Die Pharmazie 20100201

• Sumatriptan-naproxen fixed combination for acute treatment of migraine: a critical appraisal.

  Drug design, development and therapy 20100101

• Single dose oral diflunisal for acute postoperative pain in adults.

  The Cochrane database of systematic reviews 20100101

• Downstream gene activation of the receptor ALX by the agonist annexin A1.

  PloS one 20100101

• Risk of Upper Gastrointestinal Bleeding in a Cohort of New Users of Low-Dose ASA for Secondary Prevention of Cardiovascular Outcomes.

  Frontiers in pharmacology 20100101

• Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

  Bioorganic & medicinal chemistry letters 20091215

• [Therapeutic strategy for familial amyloid polyneuropathy (FAP)].

  Rinsho shinkeigaku = Clinical neurology 20091101

• Does rapid metabolism ensure negligible risk from bisphenol A?

  Environmental health perspectives 20091101

• Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets.

  Drug development and industrial pharmacy 20091001

• Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.

  British journal of clinical pharmacology 20090901

• Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-tumor agents.

  Bioorganic & medicinal chemistry letters 20090801

• Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection.

  Journal of chromatography. A 20090717

• Lumbar spondylosis: clinical presentation and treatment approaches.

  Current reviews in musculoskeletal medicine 20090601

• Modeling kinetics of subcellular disposition of chemicals.

  Chemical reviews 20090513

• Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-inflammatory agents.

  Bioorganic & medicinal chemistry letters 20090115

• Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

  PloS one 20090101

• Simultaneous determination of the two non-steroidal anti-inflammatory drugs ; diflunisal and naproxen in their tablets by chemometric spectrophotometry and HPLC.

  Pakistan journal of pharmaceutical sciences 20090101

• An overview of conventional and emerging analytical methods for the determination of mycotoxins.

  International journal of molecular sciences 20090101

• Sickle cell disease.

  BMJ clinical evidence 20090101

• Management of the critically poisoned patient.

  Scandinavian journal of trauma, resuscitation and emergency medicine 20090101

• Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

  PloS one 20090101

• Fixed drug eruption resulting from fluconazole use: a case report.

  Journal of medical case reports 20090101

• Familial (ATTR) amyloidosis misdiagnosed as the primary (AL) variant: a case report.

  Cases journal 20090101

• Recent advances in ceramic implants as drug delivery systems for biomedical applications.

  International journal of nanomedicine 20081201

• Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection.

  Journal of chromatography. A 20081121

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• Chemical substructures that enrich for biological activity.

  Bioinformatics (Oxford, England) 20081101

• In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

  Bioorganic & medicinal chemistry 20081015

• The effect of piroxicam on the formation of postoperative, intraabdominal adhesion in rats.

  Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20081001

• Simultaneous determination of two anti-inflammatory drugs in serum using isopotential fluorimetry.

  Analytica chimica acta 20080905

• Differential scanning calorimetry study on drug release from an inulin-based hydrogel and its interaction with a biomembrane model: pH and loading effect.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080902

• Simultaneous determination of naproxen and diflunisal using synchronous luminescence spectrometry.

  Journal of fluorescence 20080901

• 100,000-fold concentration of anions in capillary zone electrophoresis using electroosmotic flow controlled counterflow isotachophoretic stacking under field amplified conditions.

  Analytical chemistry 20080815

• Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3beta-glucuronidation between rats, dogs, and humans.

  Journal of pharmaceutical sciences 20080701

• Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: sublimation, solution and solvation of biphenyl substituted drugs.

  International journal of pharmaceutics 20080605

• The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation.

  The Journal of biological chemistry 20080502

• Molecular interactions in lipophilic environments studied by electrochemistry at interfaces between immiscible electrolyte solutions.

  Analytical chemistry 20080101

• Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses.

  Current pharmaceutical design 20080101

• Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites.

  The open medicinal chemistry journal 20080101

• Dendrimeric nanoarchitectures mediated transdermal and oral delivery of bioactives.

  Indian journal of pharmaceutical sciences 20080101

• Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology.

  Indian journal of pharmaceutical sciences 20080101

• Pre-emptive analgesia for removal of nasal packing: A double-blind placebo controlled study.

  Auris, nasus, larynx 20071201

• In vivo stabilization of mutant human transthyretin in transgenic mice.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20070901

• FluSTAR, a novel influenza surveillance system: outcomes from the 2005-2006 flu season.

  Southern medical journal 20070901

• Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.

  European journal of medicinal chemistry 20070701

• Diflunisal salts of bupivacaine, lidocaine and morphine. Use of the common ion effect for prolonging the release of bupivacaine from mixed salt suspensions in an in vitro dialysis model.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

• Non-steroidal anti-inflammatory drug (NSAID)-derived poly(anhydride-esters) in bone and periodontal regeneration.

  Current drug delivery 20070701

• Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction?

  PLoS medicine 20070501

• Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20070401

• The effect of 2 Hz and 100 Hz electrical stimulation of acupoint on ankle sprain in rats.

  Journal of Korean medical science 20070401

• Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

• Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers.

  Journal of pharmaceutical sciences 20070301

• A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study.

  International journal of oral and maxillofacial surgery 20070201

• Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes.

  European journal of clinical pharmacology 20070201

• Direct determination of closely overlapping drug mixtures of diflunisal and salicylic acid in serum by means of derivative matrix isopotential synchronous fluorescence spectrometry.

  Analytica chimica acta 20070130

• Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

• Allosteric modulation of [3H]EBOB binding to GABAA receptors by diflunisal analogues.

  Neurochemistry international 20061201

• Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.

  Journal of pharmaceutical sciences 20061201

• Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.

  Neuroscience research 20061201

• Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20061201

• In-vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion-probe technique.

  The Journal of pharmacy and pharmacology 20061101

• Cell based screening of inhibitors of transthyretin aggregation.

  Biochemical and biophysical research communications 20060929

• In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans.

  Biopharmaceutics & drug disposition 20060901

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Drug Insight: emerging therapies for amyloidosis.

  Nature clinical practice. Nephrology 20060501

• pH-sensitive hydrogels based on bovine serum albumin for oral drug delivery.

  International journal of pharmaceutics 20060407

• Thermally responsive polymeric micelles self-assembled by amphiphilic polyphosphazene with poly(N-isopropylacrylamide) and ethyl glycinate as side groups: polymer synthesis, characterization, and in vitro drug release study.

  Journal of biomedical materials research. Part A 20060315

• Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide.

  European journal of medicinal chemistry 20060301

• Predicting the pharmacokinetics of acyl glucuronides and their parent compounds in disease states.

  Current drug metabolism 20060201

• In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9--potent inhibition by niflumic acid.

  Biopharmaceutics & drug disposition 20060101

• Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems.

  The Analyst 20060101

• Bupivacaine salts of diflunisal and other aromatic hydroxycarboxylic acids: aqueous solubility and release characteristics from solutions and suspensions using a rotating dialysis cell model.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051101

• Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers.

  European journal of medicinal chemistry 20051101

• Determination of nonsteroidal antiinflammatory drugs in water samples using liquid chromatography coupled with diode-array detector and mass spectrometry.

  Journal of separation science 20051101

• Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs.

  The Journal of pharmacy and pharmacology 20050901

• Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.

  The Biochemical journal 20050601

• Solid-state fluorescence studies of some polymorphs of diflunisal*.

  Pharmaceutical research 20050601

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

  Journal of medicinal chemistry 20050407

• Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors.

  Bioorganic & medicinal chemistry 20050401

• UDP-glucuronosyltransferases and clinical drug-drug interactions.

  Pharmacology & therapeutics 20050401

• Photosensitizing effect of some nonsteroidal antiinflammatory drugs on natural and artificial membranes: dependence on phospholipid composition.

  Chemical research in toxicology 20050201

• In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3beta-glucuronidation in human liver microsomes.

  Biopharmaceutics & drug disposition 20050101

• Radical cross-linked albumin microspheres as potential drug delivery systems: preparation and in vitro studies.

  Drug delivery 20050101

• Aqueous-phase, palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines.

  The Journal of organic chemistry 20041112

• Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.

  The Journal of pharmacology and experimental therapeutics 20041101

• Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

  Journal of medicinal chemistry 20040923

• Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.

  The Biochemical journal 20040715

• Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.

  The Journal of biological chemistry 20040702

• Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.

  Biochemical pharmacology 20040601

• Replication of the Weber effect using postmarketing adverse event reports voluntarily submitted to the United States Food and Drug Administration.

  Pharmacotherapy 20040601

• Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants.

  Laboratory investigation; a journal of technical methods and pathology 20040501

• Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents).

  Pediatrics 20040401

• Thermodynamics of solutions III: comparison of the solvation of (+)-naproxen with other NSAIDs.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301

• Solvation and hydration characteristics of ibuprofen and acetylsalicylic acid.

  AAPS pharmSci 20040301

• The computational prediction of pharmaceutical crystal structures and polymorphism.

  Advanced drug delivery reviews 20040223

• Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.

  Journal of medicinal chemistry 20040115

• Position Paper on urine alkalinization.

  Journal of toxicology. Clinical toxicology 20040101

• Drug delivery devices based on mesoporous silicate.

  Drug delivery 20040101

• Pharmacotherapy for patellofemoral pain syndrome.

  The Cochrane database of systematic reviews 20040101

• Thermodynamics of solutions IV: Solvation of ketoprofen in comparison with other NSAIDs.

  Journal of pharmaceutical sciences 20031201

• Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.

  Journal of the American Chemical Society 20031105

• Aspirin use and lung cancer in men.

  British journal of cancer 20031103

• Identification and prediction of promiscuous aggregating inhibitors among known drugs.

  Journal of medicinal chemistry 20031009

• Effect of vehicle pretreatment on the flux, retention, and diffusion of topically applied penetrants in vitro.

  Pharmaceutical research 20030901

• The effects of organic salts on the cyclodextrin solubilization of drugs.

  International journal of pharmaceutics 20030827

• Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• Thermodynamics of solutions. II. Flurbiprofen and diflunisal as models for studying solvation of drug substances.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030801

• Method development and validation for the analysis of meloxicam in tablets by CZE.

  Journal of pharmaceutical and biomedical analysis 20030226

• Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure.

  Birth defects research. Part B, Developmental and reproductive toxicology 20030201

• Examination of 19F-NMR as a tool for investigation of drug-cyclodextrin complexes.

  Drug development and industrial pharmacy 20030101

• Synthesis and biological activities of diflunisal hydrazide-hydrazones.

  European journal of medicinal chemistry 20030101

• A study of the comparative efficacy of three common analgesics in the control of pain after third molar surgery under local anaesthesia.

  Australian dental journal 20021201

• Self-association and cyclodextrin solubilization of drugs.

  Journal of pharmaceutical sciences 20021101

• A modified HPLC method for the determination of ochratoxin A by fluorescence detection.

  Biomedical chromatography : BMC 20021001

• Physicochemical properties of amorphous salt of cimetidine and diflunisal system.

  International journal of pharmaceutics 20020725

• Solid dispersions of diflunisal-PVP: polymorphic and amorphous states of the drug.

  Drug development and industrial pharmacy 20020701

• Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions.

  AAPS PharmSciTech 20020601

• Interappointment emergencies in teeth with necrotic pulps.

  Journal of endodontics 20020501

• Interrelation between thermochemical and structural data of polymorphs exemplified by diflunisal.

  Journal of pharmaceutical sciences 20020401

• 99mTc-diflunisal and the human iris: topical application reveals localization.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401

• An improved resazurin-based cytotoxicity assay for hepatic cells.

  Cell biology and toxicology 20020101

• Rearrangement of diflunisal acyl glucuronide into its beta-glucuronidase-resistant isomers facilitates transport through the small intestine to the colon of the rat.

  Life sciences 20011121

• Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides.

  Life sciences 20011121

• Preparation and clinical application of 2% diflunisal oral ointment for painful lesions of the oral mucosa.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20011101

• Rational design of diflunisal analogues with reduced affinity for human serum albumin.

  Journal of the American Chemical Society 20011031

• Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase.

  Biochemical pharmacology 20010801

• Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100 and RL100.

  International journal of pharmaceutics 20010507

• Effect of nonsteroidal anti-inflammatory drug use on the rate of gastrointestinal hospitalizations among people living in long-term care.

  Journal of the American Geriatrics Society 20010501

• Analysis of diflunisal by electrochemical methods.

  Journal of pharmaceutical and biomedical analysis 20010401

• Celecoxib and rofecoxib. The role of COX-2 inhibitors in dental practice.

  Journal of the American Dental Association (1939) 20010401

• Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg.

  BMC medical research methodology 20010101

• Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal.

  Drug delivery 20010101

• Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation.

  Journal of analytical toxicology 20010101

• Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on-line configurations for high-throughput analysis of acidic and basic drugs in rat plasma.

  Rapid communications in mass spectrometry : RCM 20010101

• A case of eosinophilic pneumonia and vasculitis induced by diflunisal.

  Chest 19970601

• 'Relapse' of chronic active hepatitis--not always what it seems.

  Postgraduate medical journal 19960701

• Reinduction of the hypnotic effects of thiopental with NSAIDs by decreasing thiopental plasma protein binding in humans.

  Acta anaesthesiologica Scandinavica 19930401

• Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

  The Journal of pharmacology and experimental therapeutics 19930101

• Three cases of diflunisal hypersensitivity.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19880601

• Comparison between lidocaine and bupivacaine as local anesthetics with diflunisal for postoperative pain control after lower third molar surgery.

  Anesthesia progress 19880101

• Myofascial headache. Exacerbation of symptoms due to diflunisal and ranitidine therapy. A case report.

  Journal (Canadian Dental Association) 19870801

• [Hepatitis caused by diflunisal (Dolobis). Apropos of a case].

  Therapie 19870101

• [Acute renal insufficiency caused by diflunisal. Description of a case].

  Minerva medica 19860922

• Diflunisal-induced maternal anemia as a cause of teratogenicity in rabbits.

  Teratology 19841201

• Temporary hearing loss induced by combinations of intense sounds and nonsteroidal anti-inflammatory drugs.

  American journal of otolaryngology 19840101

• Acute renal failure associated with diflunisal.

  Postgraduate medical journal 19820201

• Acute interstitial nephritis and erythroderma associated with diflunisal.

  British medical journal 19800112

• Diflunisal and aspirin: a comparison of efficacy and nephrotoxicity in osteoarthritis.

  Rheumatology and rehabilitation 19790201

• Diflunisal, a new-acting analgesic and prostaglandin inhibitor: effect of concomitant acetylsalicylic acid therapy on ototoxicity and on disposition of both drugs.

  The Journal of international medical research 19790101

• A clinical trial of diflunisal against aspirin in osteoarthritis.

  Rheumatology and rehabilitation 19781101

• Nephrotoxicity studies on aspirin and diflunisal.

  Current medical research and opinion 19780101