22560-50-5 | DICHLOROMETHYLENEDIPHOSPHONIC ACID

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$10.00	$7.00
10mg	99%	in stock	$16.00	$11.00
50mg	99%	in stock	$28.00	$19.00
1g	99%	in stock	$36.00	$25.00
25g	99%	in stock	$408.00	$285.00

Description

• Catalog Number: AD23232
• Chemical Name: DICHLOROMETHYLENEDIPHOSPHONIC ACID
• CAS Number: 22560-50-5
• Molecular Formula: CH2Cl2Na2O6P2
• Molecular Weight: 288.856
• MDL Number: MFCD01632786
• SMILES: ClC(P(=O)(O)O)(P(=O)([O-])[O-])Cl.[Na+].[Na+]

Computed Properties

• Complexity: 206
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2

Literature

• Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.

  American journal of physiology. Lung cellular and molecular physiology 20130415

• Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.

  Clinical science (London, England : 1979) 20121201

• CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation.

  American journal of respiratory cell and molecular biology 20121101

• Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice.

  Kidney international 20121001

• Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.

  American journal of respiratory and critical care medicine 20120915

• Effects of low-dose doxycycline and bisphosphonate clodronate on alveolar bone loss and gingival levels of matrix metalloproteinase-9 and interleukin-1β in rats with diabetes: a histomorphometric and immunohistochemical study.

  Journal of periodontology 20120901

• Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye.

  The American journal of pathology 20120901

• Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20120801

• Bisphosphonates in early breast cancer.

  The Lancet. Oncology 20120701

• Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial.

  The Lancet. Oncology 20120701

• Nanoparticle-based clodronate delivery mitigates murine experimental colitis.

  Journal of controlled release : official journal of the Controlled Release Society 20120628

• Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial.

  Blood 20120607

• Bisphosphonates in multiple myeloma: a network meta-analysis.

  The Cochrane database of systematic reviews 20120516

• Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.

  Laboratory investigation; a journal of technical methods and pathology 20120501

• RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.

  The Journal of clinical investigation 20120402

• Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study.

  Modern rheumatology 20120401

• Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.

  Resuscitation 20120401

• Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.

  Journal of immunology (Baltimore, Md. : 1950) 20120401

• Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro.

  Bone 20120301

• Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of lys-EGFP-ki transgenic mice.

  Journal of neuropathology and experimental neurology 20120301

• Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.

  Biochemical and biophysical research communications 20120210

• Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro.

  Clinical oral investigations 20120201

• The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes--in vitro study.

  Clinical oral investigations 20120201

• The Medical Research Council Myeloma IX Trial: new clinical insights on the anticancer effects of zoledronic acid in patients with multiple myeloma.

  Clinical lymphoma, myeloma & leukemia 20120201

• Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment.

  Clinical and experimental immunology 20120201

• Depletion of macrophages and dendritic cells in ischemic acute kidney injury.

  American journal of nephrology 20120201

• Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection.

  Virology 20120120

• The Medical Research Council Myeloma IX trial: the impact on treatment paradigms.

  European journal of haematology 20120101

• P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice.

  Atherosclerosis 20120101

• Development of an injectable two-phase drug delivery system for sequential release of antiresorptive and osteogenic drugs.

  Journal of biomedical materials research. Part B, Applied biomaterials 20120101

• Effect of oral clodronate on structural damage and bone turnover in rheumatoid arthritis.

  Clinical and experimental rheumatology 20120101

• Neuroprotective function for ramified microglia in hippocampal excitotoxicity.

  Journal of neuroinflammation 20120101

• Cost-effectiveness of zoledronic acid vs clodronic acid for newly-diagnosed multiple myeloma from the United Kingdom healthcare system perspective.

  Journal of medical economics 20120101

• Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures.

  Journal of neuroinflammation 20120101

• Depletion and reconstitution of macrophages in mice.

  Journal of visualized experiments : JoVE 20120101

• The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.

  PloS one 20120101

• In vivo imaging implicates CCR2(+) monocytes as regulators of neutrophil recruitment during arthritis.

  Cellular immunology 20120101

• Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2.

  Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20111201

• Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201

• Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice.

  PLoS neglected tropical diseases 20111201

• Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa.

  Investigative ophthalmology & visual science 20111125

• Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20111101

• Economic evaluation of clodronate and zoledronate in patients diagnosed with metastatic bone disease from the perspective of public and third party payors in Brazil.

  Clinical therapeutics 20111101

• Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells.

  Journal of medicinal chemistry 20111013

• Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111001

• Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats.

  The Journal of pharmacology and experimental therapeutics 20111001

• Bisphosphonate-related osteonecrosis of the jaws associated with photodynamic therapy.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111001

• Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20111001

• Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78.

  International orthopaedics 20110901

• Further analyses of the Myeloma IX Study.

  Lancet (London, England) 20110827

• Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial.

  The Lancet. Oncology 20110801

• Zoledronic acid for all patients with newly diagnosed multiple myeloma?

  The Lancet. Oncology 20110801

• A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.

  Experimental neurology 20110701

• Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.

  International journal of radiation oncology, biology, physics 20110701

• Non-surgical management of stage 3 biphosphonate-related oroantral fistula.

  The British journal of oral & maxillofacial surgery 20110701

• Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse.

  International immunopharmacology 20110701

• Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110701

• Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury.

  The American journal of pathology 20110701

• Safety and efficacy of zoledronic acid in multiple myeloma.

  Lancet (London, England) 20110625

• Safety and efficacy of zoledronic acid in multiple myeloma.

  Lancet (London, England) 20110625

• Zoledronic acid and clodronate in the treatment of malignant bone metastases with hypercalcaemia; efficacy and safety comparative study.

  Medical oncology (Northwood, London, England) 20110601

• The influence of macrophage depletion on ligament healing.

  Connective tissue research 20110601

• Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating.

  Biotechnology letters 20110601

• Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: role of macrophages.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20110601

• Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.

  PLoS pathogens 20110601

• Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

  Blood 20110519

• Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.

  Journal of immunology (Baltimore, Md. : 1950) 20110515

• Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury.

  Arteriosclerosis, thrombosis, and vascular biology 20110501

• Fluorimetric quantification of clodronate and alendronate in aqueous samples and in serum.

  Talanta 20110415

• Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite.

  Journal of tissue engineering and regenerative medicine 20110401

• Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice.

  The British journal of dermatology 20110401

• Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice.

  Pharmaceutical research 20110401

• The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization.

  Investigative ophthalmology & visual science 20110314

• Osteonecrosis of the posterior mandible after implant insertion: a clinical and histological case report.

  Clinical implant dentistry and related research 20110301

• Can clodronate be effective in the treatment of disabling hydroxyapatite crystal-deposition disease? A report of two cases.

  Rheumatology international 20110301

• Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro.

  Oral diseases 20110301

• Depletion of alveolar macrophages abrogates prolongation of cardiac allograft survival induced by intratracheal delivery of alloantigen.

  Transplantation 20110227

• Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).

  Innate immunity 20110201

• Bisphosphonates: restrictions for vasculogenesis and angiogenesis: inhibition of cell function of endothelial progenitor cells and mature endothelial cells in vitro.

  Clinical oral investigations 20110201

• Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner.

  Shock (Augusta, Ga.) 20110201

• Interaction of clodronate with fibroblast growth factor 2 reduces FGF2-activity in endothelial cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201

• Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110201

• Steady state pharmacokinetics and dose equivalents of oral clodronate in renal failure.

  International journal of clinical pharmacology and therapeutics 20110201

• The role of the radiologist when encountering osteoporosis in women.

  AJR. American journal of roentgenology 20110201

• Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice.

  Arthritis and rheumatism 20110201

• Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease.

  Critical reviews in oncology/hematology 20110201

• Can bisphosphonates improve outcomes in patients with newly diagnosed multiple myeloma?

  Critical reviews in oncology/hematology 20110201

• HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

  Cancer cell 20110118

• Effects of two administration schemes of intramuscular clodronic acid on bone mineral density: a randomized, open-label, parallel-group study.

  Clinical drug investigation 20110101

• TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P.

  The international journal of biochemistry & cell biology 20110101

• Supportive therapy in multiple myeloma.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20110101

• [Regression of an osteolytic lesion in a patient with multiple myeloma treated with clodronate after a successful therapy with bortezomib-based regimen].

  Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20110101

• Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice.

  BMC immunology 20110101

• Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice.

  PloS one 20110101

• Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates.

  Drug design, development and therapy 20110101

• Bisphosphonates and breast cancer incidence and recurrence.

  Breast disease 20110101

• Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

  Journal of neuroimmunology 20101215

• Zoledronic acid in myeloma: MRC Myeloma IX.

  Lancet (London, England) 20101211

• First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial.

  Lancet (London, England) 20101202

• Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.

  Toxicology letters 20101130

• The role of Tregs and CD11c(+) macrophages/dendritic cells in ischemic preconditioning of the kidney.

  Kidney international 20101101

• Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice.

  Journal of hepatology 20101101

• Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20101101

• Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis.

  Journal of Zhejiang University. Science. B 20101101

• Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces: a histomorphometric analysis.

  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20101101

• Bisphosphonates as anticancer therapy for early breast cancer.

  Clinical breast cancer 20101001

• Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.

  Organic & biomolecular chemistry 20100921

• In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

  Journal of immunology (Baltimore, Md. : 1950) 20100915

• Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

  Journal of neuroimmunology 20100914

• Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis.

  European journal of gastroenterology & hepatology 20100901

• Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100901

• Bone-marker levels in patients with prostate cancer: potential correlations with outcomes.

  Current opinion in supportive and palliative care 20100901

• Technical advance: autofluorescence as a tool for myeloid cell analysis.

  Journal of leukocyte biology 20100901

• Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

  Glia 20100901

• [Bisphosphonates in adjuvant therapy of breast cancer].

  Medizinische Klinik (Munich, Germany : 1983) 20100901

• Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100801

• Effects of continuous combined hormone replacement therapy and clodronate on bone mineral density in osteoporotic postmenopausal women: a 5-year follow-up.

  Maturitas 20100801

• Involvement of natural killer T cells in halothane-induced liver injury in mice.

  Biochemical pharmacology 20100715

• Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100701

• Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity.

  Transplantation 20100615

• Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products.

  Dalton transactions (Cambridge, England : 2003) 20100614

• Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601

• Decreased periprosthetic bone loss in patients treated with clodronate: a 1-year randomized controlled study.

  Calcified tissue international 20100601

• Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review.

  European journal of clinical pharmacology 20100601

• The evolving role of bone-conserving therapy in patients with breast cancer.

  Seminars in oncology 20100601

• Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.

  Journal of immunology (Baltimore, Md. : 1950) 20100515

• Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage.

  Brain, behavior, and immunity 20100501

• Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.

  Nature immunology 20100501

• Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100501

• 'Twice-a-month' clodronate 200 mg IM: a new dosing regimen and improved therapy adherence in the treatment of postmenopausal osteoporosis.

  Advances in therapy 20100501

• Kupffer cells participate in 2-butoxyethanol-induced liver hemangiosarcomas.

  Toxicology 20100411

• 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.

  The FEBS journal 20100401

• MRI shows clodronate-liposomes attenuating liver injury in rats with severe acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20100401

• Bisphosphonates in adjuvant treatment of early breast cancer.

  Critical reviews in oncology/hematology 20100401

• Routine adjuvant use of bisphosphonates in breast cancer arguments in favour and against.

  Critical reviews in oncology/hematology 20100401

• Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs.

  Cancer immunology, immunotherapy : CII 20100301

• Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats.

  Hypertension (Dallas, Tex. : 1979) 20100301

• Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction.

  Hypertension (Dallas, Tex. : 1979) 20100301

• Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy.

  Cancer research 20100215

• Gastric and esophagus events before and during treatment of osteoporosis.

  Calcified tissue international 20100201

• Effect of oral clodronate on bone mass, bone turnover and subsequent metastases in women with primary breast cancer.

  European journal of cancer (Oxford, England : 1990) 20100201

• Rapid analysis of alkylphosphonate drugs by capillary zone electrophoresis using indirect ultraviolet detection.

  Journal of separation science 20100201

• Clodronate liposomes: all sites of injection are not equal.

  Hepatology (Baltimore, Md.) 20100201

• Kupffer cell activation is a causal factor for hepatic insulin resistance.

  American journal of physiology. Gastrointestinal and liver physiology 20100101

• Phosphatase inhibitors with anti-angiogenic effect in vitro.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20100101

• Liposomes for specific depletion of macrophages from organs and tissues.

  Methods in molecular biology (Clifton, N.J.) 20100101

• In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis.

  BMC microbiology 20100101

• Apoptosis and autoimmunity induced by clodronate in systemic lupus erythematosus mononuclear circulating cells.

  International journal of immunopathology and pharmacology 20100101

• Rejection of intradermally injected syngeneic tumor cells from mice by specific elimination of tumor-associated macrophages with liposome-encapsulated dichloromethylene diphosphonate, followed by induction of CD11b(+)/CCR3(-)/Gr-1(-) cells cytotoxic against the tumor cells.

  Cancer immunology, immunotherapy : CII 20091201

• Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20091201

• Further analysis of the survival benefit of clodronate.

  Cancer biology & therapy 20091201

• Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.

  Viral immunology 20091201

• Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling.

  Biochimica et biophysica acta 20091101

• Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands.

  The American journal of pathology 20091101

• Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy.

  Journal of pharmacological sciences 20091101

• Fate of endothelialized modular constructs implanted in an omental pouch in nude rats.

  Tissue engineering. Part A 20091001

• How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B.

  Brain, behavior, and immunity 20091001

• Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control.

  European journal of immunology 20091001

• Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm.

  The American journal of pathology 20091001

• Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.

  PLoS pathogens 20091001

• The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

  Chemistry & biology 20090925

• Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials.

  The Lancet. Oncology 20090909

• Elevated endogenous surfactant reduces inflammation in an acute lung injury model.

  Experimental lung research 20090901

• c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury.

  Transplantation 20090815

• Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway.

  The Journal of pharmacology and experimental therapeutics 20090801

• TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice.

  The journal of gene medicine 20090801

• Intra-articular clodronate for the treatment of knee osteoarthritis: dose ranging study vs hyaluronic acid.

  Rheumatology (Oxford, England) 20090701

• Adjuvant bisphosphonates in breast cancer: are we witnessing the emergence of a new therapeutic strategy?

  European journal of cancer (Oxford, England : 1990) 20090701

• Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice.

  The Journal of clinical investigation 20090701

• Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.

  Experimental animals 20090701

• Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro.

  British journal of pharmacology 20090601

• Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization.

  Cornea 20090601

• Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated.

  Cancer research 20090601

• Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury.

  American journal of respiratory and critical care medicine 20090515

• Ten-year fracture probability identifies women who will benefit from clodronate therapy--additional results from a double-blind, placebo-controlled randomised study.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090501

• Potential role of macrophages in experimental keratomycosis.

  Investigative ophthalmology & visual science 20090501

• Macrophage depletion delays progression of neuropathic pain in diabetic animals.

  Naunyn-Schmiedeberg's archives of pharmacology 20090501

• Effect of depletion of monocytes/macrophages on early aortic valve lesion in experimental hyperlipidemia.

  Cell and tissue research 20090501

• Necrotic actions of nitrogen-containing bisphosphonates and their inhibition by clodronate, a non-nitrogen-containing bisphosphonate in mice: potential for utilization of clodronate as a combination drug with a nitrogen-containing bisphosphonate.

  Basic & clinical pharmacology & toxicology 20090501

• Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: a meta-analysis of randomized clinical trials.

  Clinical therapeutics 20090501

• Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing's syndrome.

  Journal of endocrinological investigation 20090501

• Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function.

  Toxicology and applied pharmacology 20090401

• Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy.

  Journal of cardiovascular pharmacology and therapeutics 20090301

• Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1.

  Toxicology and applied pharmacology 20090215

• Effect of macrophage depletion on viral DNA rebound following antiretroviral therapy in a murine model of AIDS (MAIDS).

  Antiviral research 20090201

• Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia.

  American journal of physiology. Lung cellular and molecular physiology 20090201

• Treating low- and medium-potency bisphosphonate-related osteonecrosis of the jaws with a protocol for the treatment of chronic suppurative osteomyelitis: report of 7 cases.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090201

• Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model.

  Neoplasia (New York, N.Y.) 20090201

• Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice.

  Innate immunity 20090201

• Clinical application of bisphosphonates in implant dentistry: histomorphometric evaluation.

  The International journal of periodontics & restorative dentistry 20090201

• Value of information and value of implementation: application of an analytic framework to inform resource allocation decisions in metastatic hormone-refractory prostate cancer.

  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

• Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling.

  American journal of physiology. Gastrointestinal and liver physiology 20090101

• WHO fracture risk calculator (FRAX) in the assessment of obese patients with osteoporosis.

  Endokrynologia Polska 20090101

• RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro.

  Arthritis research & therapy 20090101

• Clodronic acid formulations available in Europe and their use in osteoporosis: a review.

  Clinical drug investigation 20090101

• Resident macrophages influence stem cell activity in the mammary gland.

  Breast cancer research : BCR 20090101

• Clodronate combined with a surfactant (Tween 20) does not improve osseointegration: a rabbit immunohistomorphometric study.

  International journal of immunopathology and pharmacology 20090101

• Tartrate-resistant acid phosphatase (TRAP) as a serum marker for bone resorption in breast cancer patients with bone metastases.

  Clinical and experimental obstetrics & gynecology 20090101

• Efficacy of intramuscular clodronate in Complex Regional Pain Syndrome type I: description of a case located in the astragalus in a patient with psoriatic arthritis.

  Acta bio-medica : Atenei Parmensis 20090101

• Immune-to-brain signalling: the role of cerebral CD163-positive macrophages.

  Neuroscience letters 20081219

• Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo).

  Journal of the neurological sciences 20081215

• Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.

  The Journal of infectious diseases 20081215

• The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201

• Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up.

  Annals of oncology : official journal of the European Society for Medical Oncology 20081201

• Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.

  Toxicon : official journal of the International Society on Toxinology 20081201

• Vitamin D receptor gene polymorphisms predict acquired resistance to clodronate treatment in patients with Paget's disease of bone.

  Calcified tissue international 20081201

• Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomes.

  Bioconjugate chemistry 20081201

• Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents.

  The British journal of ophthalmology 20081101

• [Bisphosphonates for osseus invasion caused by bronchial carcinoma].

  Deutsche medizinische Wochenschrift (1946) 20081101

• Postmenopausal osteoporosis. The role of intravenous bisphosphonates.

  Advance for nurse practitioners 20081101

• Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation.

  Journal of neuroimmunology 20081015

• Platelet dynamics in the early phase of postischemic liver in vivo.

  The Journal of surgical research 20081001

• Vertebral fracture assessment (VFA) with a densitometer predicts future fractures in elderly women unselected for osteoporosis.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20081001

• Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord.

  Neuropharmacology 20081001

• Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells.

  Immunity 20080919

• Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080917

• Ten-year follow-up of 3 years of oral adjuvant clodronate therapy shows significant prevention of osteoporosis in early-stage breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080910

• Investigation into the role of tumor-associated macrophages in the antitumor activity of Doxil.

  Pharmaceutical research 20080801

• Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.

  American journal of physiology. Gastrointestinal and liver physiology 20080801

• Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice.

  American journal of physiology. Lung cellular and molecular physiology 20080801

• Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages.

  Journal of drug targeting 20080801

• Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.

  Cancer science 20080801

• Tumoricidal activity of high-dose tumor necrosis factor-alpha is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown.

  International journal of cancer 20080715

• A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.

  Bioorganic & medicinal chemistry 20080715

• Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock.

  Microcirculation (New York, N.Y. : 1994) 20080701

• Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model.

  Journal of biomedical materials research. Part A 20080615

• Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety.

  Toxicology in vitro : an international journal published in association with BIBRA 20080601

• Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis.

  The Journal of pathology 20080601

• The investigation of macrophage infiltration in the early phase of ischemic acute renal failure in mice.

  The Korean journal of internal medicine 20080601

• Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion.

  Cell and tissue research 20080501

• Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080501

• Clodronate inhibits angiogenesis in vitro and in vivo.

  Oncology reports 20080501

• Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event.

  The Journal of trauma 20080501

• The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo.

  Nuclear medicine and biology 20080501

• Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation.

  American journal of physiology. Lung cellular and molecular physiology 20080401

• Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.

  Hypertension (Dallas, Tex. : 1979) 20080401

• Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma.

  Molecular cancer therapeutics 20080401

• Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth.

  Anti-cancer drugs 20080401

• Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid.

  Clinical lymphoma & myeloma 20080401

• Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080301

• Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080301

• The role of macrophages in early healing of a tendon graft in a bone tunnel.

  The Journal of bone and joint surgery. American volume 20080301

• [Osteonecrosis of the jaw developing during bisphosphonate treatment].

  Magyar onkologia 20080301

• Prolonged islet allograft survival in diabetic mice upon macrophage depletion by clodronate-loaded erythrocytes.

  Transplantation 20080227

• Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.

  Journal of cellular physiology 20080201

• Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue.

  Neoplasia (New York, N.Y.) 20080201

• Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways.

  European journal of pharmacology 20080128

• Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases.

  Journal of vascular research 20080101

• Macrophage involvement in the kidney repair phase after ischaemia/reperfusion injury.

  The Journal of pathology 20080101

• Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis.

  Cellular immunology 20080101

• Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model.

  Anticancer research 20080101

• Cost-effectiveness of oral clodronate compared with oral ibandronate, intravenous zoledronate or intravenous pamidronate in breast cancer patients.

  The Journal of international medical research 20080101

• Application of UV-derivative spectrophotometry for determination of some bisphosphonates drugs in pharmaceutical formulations.

  Acta poloniae pharmaceutica 20080101

• Are new-generation bisphosphonates effective for the inhibition of calcium oxalate stone formation in a rat model?

  Urologia internationalis 20080101

• Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.

  Cancer science 20071201

• Antiangiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice.

  Investigative ophthalmology & visual science 20071201

• Evidence based medicine and effective interventions of pharmacological therapy for the prevention of osteoporotic fractures.

  Minerva endocrinologica 20071201

• Different responses of macrophages in retinal ganglion cell survival after acute ocular hypertension in rats with different autoimmune backgrounds.

  Experimental eye research 20071101

• The use of bone markers in a 6-week study to assess the efficacy of oral clodronate in patients with metastatic bone disease.

  Calcified tissue international 20071101

• Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.

  Journal of hepatology 20071001

• Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice.

  American journal of physiology. Cell physiology 20071001

• Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia.

  Journal of applied physiology (Bethesda, Md. : 1985) 20071001

• A double-blind placebo-controlled study of intravenous clodronate for prevention of steroid-induced bone loss in inflammatory bowel disease.

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071001

• Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.

  The Journal of clinical investigation 20071001

• Development and application of a high-performance liquid chromatography-mass spectrometry method to determine alendronate in human urine.

  Journal of chromatography. A 20070810

• Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20070801

• Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.

  The Journal of investigative dermatology 20070801

• Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.

  Bioorganic & medicinal chemistry letters 20070801

• PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.

  The European journal of neuroscience 20070801

• Reduction in alveolar macrophages attenuates acute ventilator induced lung injury in rats.

  Intensive care medicine 20070701

• Oral sodium clodronate induced osteonecrosis of the jaw in a patient with myeloma.

  European journal of haematology 20070701

• Murine alveolar macrophages limit replication of vaccinia virus.

  Virology 20070620

• Meta-analysis of clodronate and breast cancer survival.

  British journal of cancer 20070618

• Bisphosphonates: are they standard of care for the treatment of breast cancer?

  British journal of cancer 20070618

• A 4-year treatment with clodronate plus calcium and vitamin D supplements does not improve bone mass in primary biliary cirrhosis.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070601

• Oral sodium clodronate for nonmetastatic prostate cancer--results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873).

  Journal of the National Cancer Institute 20070516

• Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy.

  Molecular therapy : the journal of the American Society of Gene Therapy 20070501

• Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract.

  Infection and immunity 20070401

• [Relevance of bisphosphonate long-term therapy in radiation therapy of endosteal jaw metastases].

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20070401

• Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro.

  Aging clinical and experimental research 20070401

• Comparative study of the protective effect of different intravenous bisphosphonates on the decrease in bone mineral density in patients submitted to radical prostatectomy undergoing androgen deprivation therapy. A prospective open-label controlled study.

  International journal of urology : official journal of the Japanese Urological Association 20070401

• Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis.

  The Journal of comparative neurology 20070310

• Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury.

  Journal of neuroscience research 20070301

• Severe osteomyelitis of the mandible associated with the use of non-nitrogen-containing bisphosphonate (disodium clodronate): report of a case.

  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070301

• New multifunctional anti-osteolytic releasing bioabsorbable implant.

  The Journal of craniofacial surgery 20070301

• Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis.

  Journal of the National Cancer Institute 20070221

• Differential effects of bisphosphonates on breast cancer cell lines.

  Cancer letters 20070208

• Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells.

  International immunopharmacology 20070201

• [Experimental study for thrombocytopenic purpura therapy by targeting macrophages in liver and spleen].

  Zhongguo shi yan xue ye xue za zhi 20070201

• Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070101

• Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats.

  Nephron. Experimental nephrology 20070101

• C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors.

  Journal of immunology (Baltimore, Md. : 1950) 20070101

• Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.

  Arthritis and rheumatism 20070101

• Clinical usefulness of bisphosphonates in oncology: treatment of bone metastases, antitumoral activity and effect on bone resorption markers.

  The International journal of biological markers 20070101

• Clodronic acid in the treatment of postmenopausal osteoporosis.

  Clinical drug investigation 20070101

• Pharmacologic modulation of clodronate in local therapy of periodontal and implant inflammation.

  International journal of immunopathology and pharmacology 20070101

• Effect of bisphosphonates on nitric oxide production by inflammatory activated chondrocytes.

  Clinical and experimental rheumatology 20070101

• Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate.

  The Journal of organic chemistry 20061208

• Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.

  American journal of physiology. Lung cellular and molecular physiology 20061201

• Tumor necrosis factor alpha and macrophages in the brain of herpes simplex virus type 1-infected BALB/c mice.

  Journal of neurovirology 20061201

• Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients.

  Acta orthopaedica 20061201

• Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury.

  American journal of physiology. Lung cellular and molecular physiology 20061101

• A new model for limbal transplantation using E-GFP for follow-up of transplant survival.

  Experimental eye research 20061101

• Intracorneal instillation of latex beads induces macrophage-dependent protection against Acanthamoeba keratitis.

  Investigative ophthalmology & visual science 20061101

• Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapy.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061020

• Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase.

  FEBS letters 20061016

• Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs.

  Experimental hematology 20061001

• Antioxidant effect of bisphosphonates and simvastatin on chondrocyte lipid peroxidation.

  Biochemical and biophysical research communications 20060922

• Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin.

  Archives of toxicology 20060901

• Targeting study of gelatin adsorbed clodronate in reticuloendothelial system and its potential application in immune thrombocytopenic purpura of rat model.

  Journal of controlled release : official journal of the Controlled Release Society 20060828

• Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach.

  British journal of cancer 20060807

• Efficient gene transfer into macrophages and dendritic cells by in vivo gene delivery with mannosylated lipoplex via the intraperitoneal route.

  The Journal of pharmacology and experimental therapeutics 20060801

• Clodronate inhibits PGE(2) production in compressed periodontal ligament cells.

  Journal of dental research 20060801

• Potential role of microglia in retinal blood vessel formation.

  Investigative ophthalmology & visual science 20060801

• Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.

  The Journal of clinical investigation 20060801

• Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line.

  The Journal of endocrinology 20060801

• Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII.

  Circulation research 20060707

• Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV).

  Clinical and experimental immunology 20060701

• Macrophages are vital in spontaneous intraocular tumor eradication.

  Investigative ophthalmology & visual science 20060701

• Effects of macrophage inducible nitric oxide synthase in murine septic lung injury.

  American journal of physiology. Lung cellular and molecular physiology 20060601

• Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060601

• Fracture prevention in postmenopausal women.

  Clinical evidence 20060601

• Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate.

  Toxicology and applied pharmacology 20060515

• Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis.

  Molecular pharmacology 20060501

• Antigen sensitization modulates alveolar macrophage functions in an asthma model.

  American journal of physiology. Lung cellular and molecular physiology 20060501

• Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.

  Blood 20060415

• Liver-stage development of Plasmodium falciparum, in a humanized mouse model.

  The Journal of infectious diseases 20060401

• Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.

  Bioorganic & medicinal chemistry 20060301

• Kupffer cells abrogate cholestatic liver injury in mice.

  Gastroenterology 20060301

• Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

  Immunity 20060201

• Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060101

• The use of bisphosphonates in palliative treatment of bone metastases in a terminally ill, oncological elderly population.

  Archives of gerontology and geriatrics 20060101

• Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026].

  Breast cancer research : BCR 20060101

• Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism.

  Journal of bone and mineral metabolism 20060101

• Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187.

  Methods and findings in experimental and clinical pharmacology 20060101

• Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis.

  Clinical and experimental rheumatology 20060101

• The incidence of jaw osteonecrosis in multiple myeloma patients treated with bisphosphonates.

  Acta poloniae pharmaceutica 20060101

• Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051201

• Acute renal effects of intravenous bisphosphonates in the rat.

  Basic & clinical pharmacology & toxicology 20051201

• Macrophages are involved in hexachlorobenzene-induced adverse immune effects.

  Toxicology and applied pharmacology 20051115

• Aging of red blood cells and impaired erythropoiesis following prolonged administration of dichloromethylene diphosphonate containing liposomes in rats.

  European journal of haematology 20051101

• Intermittent intramuscular clodronate therapy: a valuable option for older osteoporotic women.

  Age and ageing 20051101

• S0307. Phase III trial of bisphosphonates as adjuvant therapy for primary breast cancer.

  Clinical advances in hematology & oncology : H&O 20051101

• Real-time in vivo imaging of apoptotic cell membrane changes in monocytes and macrophages.

  Apoptosis : an international journal on programmed cell death 20051001

• Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay.

  Anti-cancer drugs 20051001

• Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model.

  Basic & clinical pharmacology & toxicology 20051001

• A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis.

  European journal of immunology 20051001

• Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050901

• Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells.

  Clinical and experimental immunology 20050901

• Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

  Journal of neuropathology and experimental neurology 20050901

• Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells.

  Molecular and cellular endocrinology 20050830

• Three-year oral clodronate treatment does not impair mineralization of newly formed bone--a histomorphometric study.

  Calcified tissue international 20050801

• Role of gut macrophages in mice orally contaminated with scrapie or BSE.

  International journal of pharmaceutics 20050725

• The effect of clodronate on the integrity and viability of rat small intestine in vitro-a comparison with EDTA.

  Biological & pharmaceutical bulletin 20050701

• Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate.

  Calcified tissue international 20050601

• Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo.

  Hepatology (Baltimore, Md.) 20050501

• Bisphosphonates in breast cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20050501

• The role of bisphosphonates in the treatment of prostate cancer.

  BJU international 20050501

• The issue of renal safety of zoledronic acid from a nephrologist's point of view.

  The oncologist 20050501

• 'Safety and convenience of a 15-minute infusion of zoledronic acid': not so safe.

  The oncologist 20050501

• The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells.

  Chemical research in toxicology 20050501

• Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages.

  American journal of physiology. Renal physiology 20050401

• Bacterial adhesion to bisphosphonate coated hydroxyapatite.

  Journal of materials science. Materials in medicine 20050401

• Should oral bisphosphonates be standard of care in women with early breast cancer?

  Breast cancer research and treatment 20050401

• Clodronate in the prevention and treatment of skeletal metastasis.

  Expert review of anticancer therapy 20050401

• Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis.

  Cell biology international 20050401

• Clodronate treatment influences MMP-2 associated outcome in node positive breast cancer.

  Breast cancer research and treatment 20050301

• [Pharmacological treatment of osteitis deformans (Paget's bone disease)].

  Ugeskrift for laeger 20050227

• Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation.

  Journal of leukocyte biology 20050201

• Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial.

  Head & neck 20050201

• Evolving role of bisphosphonates in women undergoing treatment for localized and advanced breast cancer.

  Clinical breast cancer 20050201

• Macrophage depletion induced by clodronate-loaded erythrocytes.

  Journal of drug targeting 20050201

• [Effect of glucocorticoids on bone mineral density in patients with idiopathic thrombocytopenic purpura].

  [Rinsho ketsueki] The Japanese journal of clinical hematology 20050201

• [Diphosphonates in solid malignant tumors].

  Ugeskrift for laeger 20050124

• Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis.

  European journal of pediatrics 20050101

• Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats.

  Journal of hepatology 20050101

• Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050101

• The role of Kupffer cells after major liver surgery.

  JPEN. Journal of parenteral and enteral nutrition 20050101

• The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 1: Mechanisms of action, role of biomarkers and preclinical applications.

  Oncology 20050101

• [The effects of clodronate for the pain treatment of bone metastasis due to prostate cancer].

  Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20050101

• Macrophage depletion prevents anti-graft antibody production and results in long-term survival in xenotransplantation.

  Transplantation proceedings 20050101

• Adjuvant clodronate in breast cancer.

  Acta oncologica (Stockholm, Sweden) 20050101

• Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate.

  Experimental lung research 20050101

• [Association between primary hyperparathyroidism and Paget's disease. Report of a case].

  Anales otorrinolaringologicos ibero-americanos 20050101

• [Zoledronic acid and bone pathology in the course of neoplasia. Part I].

  Tumori 20050101

• Cost analysis of secondary prophylaxis with oral clodronate versus pamidronate in metastatic breast cancer patients.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20041201

• Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells.

  British journal of cancer 20041101

• [Synthesis of phosphonic acid and phosphinic acid derivatives for development of biologically active compounds].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101

• Enhanced engraftment of human cells in RAG2/gammac double-knockout mice after treatment with CL2MDP liposomes.

  Experimental hematology 20041101

• Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures.

  Experimental neurology 20041001

• The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores.

  Microbial pathogenesis 20041001

• Bisphosphonates in the treatment of skeletal metastases.

  Seminars in oncology 20041001

• Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats.

  European journal of orthodontics 20041001

• Severe osteomyelitis of the jaw in long-term survivors of multiple myeloma: a new clinical entity.

  The American journal of medicine 20040915

• Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates.

  Calcified tissue international 20040901

• Short-term intermittent intravenous clodronate in the prevention of bone loss related to chemotherapy-induced ovarian failure.

  Breast cancer research and treatment 20040901

• Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).

  Steroids 20040901

• In vitro toxicity of bisphosphonates on human neuroblastoma cell lines.

  Anti-cancer drugs 20040901

• Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells.

  British journal of cancer 20040816

• Tamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids.

  British journal of cancer 20040802

• Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.

  American journal of respiratory cell and molecular biology 20040701

• Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer.

  Current oncology reports 20040701

• Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception.

  Anesthesiology 20040701

• Macrophages play a role in the early phase of corneal allograft rejection in rats.

  Transplantation 20040615

• Hypocalcaemia after intravenous bisphosphonate: adjuvant bisphosphonate is not currently accepted practice.

  BMJ (Clinical research ed.) 20040612

• Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism.

  Experimental eye research 20040601

• Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction.

  American journal of physiology. Lung cellular and molecular physiology 20040601

• Kupffer cell-depleted rats have a diminished acute-phase response following major liver resection.

  Shock (Augusta, Ga.) 20040601

• Role of macrophages in a mouse model of postoperative MRSA enteritis.

  The Journal of surgical research 20040515

• Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules.

  American journal of physiology. Lung cellular and molecular physiology 20040501

• Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040501

• Peripheral macrophage depletion reduces central nervous system parasitism and damage in Trypanosoma cruzi-infected suckling rats.

  Journal of neuroimmunology 20040401

• Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta1 in healing rat vein grafts.

  Journal of vascular surgery 20040401

• Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate.

  Experimental lung research 20040301

• Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis.

  Inflammation 20040201

• Determination of disodium clodronate in human plasma and urine using gas-chromatography-nitrogen-phosphorous detections: validation and application in pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105

• Effects of weekly administrations of alendronate+clodronate on young mouse tibia: localized action at the proximal growth plate.

  Calcified tissue international 20040101

• Utilization of palliative radiotherapy for breast cancer patients with bone metastases treated with bisphosphonates-Toronto Sunnybrook Regional Cancer Centre experience.

  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20040101

• Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.

  Arthritis and rheumatism 20040101

• Safety and convenience of a 15-minute infusion of zoledronic acid.

  The oncologist 20040101

• A tolerability and pharmacokinetic study of a new injectable formulation of disodium clodronate in healthy female volunteers.

  European journal of drug metabolism and pharmacokinetics 20040101

• Antiresorption therapy and reduction in fracture susceptibility in the osteoporotic elderly patient: open study.

  European review for medical and pharmacological sciences 20040101

• Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines.

  Anticancer research 20040101

• Use of 18O3-clodronate as an internal standard for the quantitative analysis of clodronate in human plasma by gas chromatography/electron ionisation mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice.

  Current eye research 20040101

• Use of bisphosphonates can dramatically improve pain in advanced hormone-refractory prostate cancer patients.

  Prostate cancer and prostatic diseases 20040101

• Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients.

  Acta oncologica (Stockholm, Sweden) 20040101

• Clodronate : a review of its use in the prevention of bone metastases and the management of skeletal complications associated with bone metastases in patients with breast cancer.

  Drugs & aging 20040101

• Macrophage derived signalling regulates negatively the megakaryocyte compartment.

  Cellular and molecular biology (Noisy-le-Grand, France) 20040101

• [Expanding the possibilities of using biphosphonates for prophylaxis and treatment of osteal complications in malignant metastasis].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• [AIOM Conference 2004. Endocrine therapy and management of patients with bone metastasis of breast cancer].

  Tumori 20040101

• Effects of macrophage depletion on peritoneal inflammation in swiss mice, edible frogs and goldfish.

  Folia biologica 20040101

• Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates.

  Diseases of aquatic organisms 20031203

• Bisphosphonates to prevent skeletal complications in men with metastatic prostate cancer.

  The Journal of urology 20031201

• Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.

  Journal of periodontal research 20031201

• A single bisphosphonate infusion is associated with improved functional capacity in elderly subjects with primary hyperparathyroidism.

  Aging clinical and experimental research 20031201

• Use of dichloromethylene bisphosphonate (Cl2MBP) to deplete macrophage function in the chicken.

  British poultry science 20031201

• Bisphosphonate therapy in the oncology setting.

  Expert opinion on emerging drugs 20031101

• Oral clodronate therapy for hypercalcemia related to extensive subcutaneous fat necrosis in a newborn.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20031101

• Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt.

  The Journal of biological chemistry 20031031

• A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.

  Blood 20031001

• Oral clodronate as treatment of osteogenesis imperfecta.

  Archives of disease in childhood 20031001

• Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?

  Pancreas 20031001

• The bisphosphonate pamidronate is a potent inhibitor of Ewing's sarcoma cell growth in vitro.

  Anti-cancer drugs 20031001

• Long-term analgesic effect of clodronate in rodents.

  Bone 20031001

• Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound.

  Bone 20031001

• Efficacy of disodium-clodronate in the management of joint pain in rheumatoid arthritis. Six months open study.

  Minerva medica 20031001

• Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates.

  Life sciences 20030926

• Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells.

  Blood 20030915

• Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures.

  European journal of pharmacology 20030905

• Bisphosphonates in prostate cancer: where are we and where should we go?

  Journal of the National Cancer Institute 20030903

• Clinical trials test bisphosphonates in hormone-sensitive prostate cancer.

  Journal of the National Cancer Institute 20030903

• A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial).

  Journal of the National Cancer Institute 20030903

• Randomized, double-blind, controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone and placebo in patients with hormone-refractory prostate cancer and pain.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901

• Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration.

  Journal of pain and symptom management 20030901

• Mechanism of action of bisphosphonates.

  Current osteoporosis reports 20030901

• Effects of various absorption enhancers on transport of clodronate through Caco-2 cells.

  International journal of pharmaceutics 20030811

• Expression of fractalkine in the rat testis: molecular cloning of a novel alternative transcript of its gene that is differentially regulated by pro-inflammatory cytokines.

  Molecular human reproduction 20030801

• Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses.

  Journal of immunology (Baltimore, Md. : 1950) 20030801

• Macrophage depletion inhibits experimental choroidal neovascularization.

  Investigative ophthalmology & visual science 20030801

• Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization.

  Investigative ophthalmology & visual science 20030801

• Bisphosphonate resistance in Paget's disease of bone.

  Arthritis and rheumatism 20030801

• Using of disodium clodronate on DSO patients.

  International journal of oral and maxillofacial surgery 20030801

• Injectable bisphosphonates in the treatment of postmenopausal osteoporosis.

  Aging clinical and experimental research 20030801

• Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate.

  The Journal of surgical research 20030601

• Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB/c mice.

  Journal of immunology (Baltimore, Md. : 1950) 20030515

• Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.

  Xenotransplantation 20030501

• Adhesion molecule expression in local-macrophage-depleted rats bearing orthotopic corneal allografts.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030501

• The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures.

  Experimental neurology 20030501

• Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030501

• Aetiology of bone disease and the role of bisphosphonates in multiple myeloma.

  The Lancet. Oncology 20030501

• Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.

  The Journal of surgical research 20030501

• Clodronate induced uveitis.

  Annals of the rheumatic diseases 20030401

• Macrophage depletion following liposomal-encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice.

  British journal of haematology 20030401

• Determination of clodronate content in liposomal formulation by capillary zone electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20030401

• Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (Cl2MBP) suppresses nitric oxide production and reduces genetic resistance to Marek's disease.

  Avian pathology : journal of the W.V.P.A 20030401

• Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.

  Blood 20030301

• Long-term administration of clodronate does not prevent fracture healing in rats.

  Clinical orthopaedics and related research 20030301

• [A patient with gastric cancer complicated with severe DIC and multiple bone metastasis showing a high response to combination of TS-1 and CDDP].

  Gan to kagaku ryoho. Cancer & chemotherapy 20030301

• Biodegradable microspheres targeting mucosal immune-regulating cells: new approach for treatment of inflammatory bowel disease.

  Journal of gastroenterology 20030301

• Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low-calcium diet.

  Journal of medical and dental sciences 20030301

• Clodronate treatment of established bone loss in cardiac recipients: a randomized study.

  Transplantation 20030215

• Current and future status of adjuvant therapy for breast cancer.

  Cancer 20030201

• Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030201

• Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.

  Digestive diseases and sciences 20030201

• Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts.

  Current eye research 20030201

• Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model.

  Blood 20030115

• Characterization of an in vitro model of calcification in retinal pigmented epithelial cells.

  Journal of atherosclerosis and thrombosis 20030101

• Severe transient osteoporosis of the hip during pregnancy. Successful treatment with intravenous biphosphonates.

  Clinical and experimental rheumatology 20030101

• Biochemical markers of bone turnover, serum levels of interleukin-6/interleukin-6 soluble receptor and bisphosphonate treatment in Erdheim-Chester disease.

  Clinical and experimental rheumatology 20030101

• Extended safety profile of oral clodronate after long-term use in primary breast cancer patients.

  Drug safety 20030101

• Effect of elimination of donor Kupffer cells and/or recipient macrophages on acute rejection in liver transplantation.

  Hepato-gastroenterology 20030101

• [The use of parenteral clodronate in elderly women with postmenopausal osteoporosis: compliance, effects on bone mineral density and on bone turnover].

  Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna 20030101

• Effect of raloxifene and clodronate on bone density in postmenopausal osteoporotic women.

  International journal of tissue reactions 20030101

• Should all adjuvant breast cancer patients receive a bisphosphonate?

  Breast cancer research : BCR 20030101

• Quantitative ultrasound of bone and clodronate effects in thalassemia-induced osteoporosis.

  Journal of bone and mineral metabolism 20030101

• [Prognostication of hematotoxicity for radio- and chemotherapy in patients with breast cancer].

  Voprosy onkologii 20030101

• Clodronate as a single-dose intravenous infusion effectively provides short-term correction of malignant hypercalcemia.

  Acta oncologica (Stockholm, Sweden) 20030101

• 'In vivo' depletion of macrophages by liposome-mediated 'suicide'.

  Methods in enzymology 20030101

• APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease.

  Journal of immunology (Baltimore, Md. : 1950) 20021215

• Prevention of bone loss by clodronate in early postmenopausal women with vertebral osteopenia: a dose-finding study.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20021201

• Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain.

  Pain 20021201

• Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.

  Chemical research in toxicology 20021201

• Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints.

  American journal of clinical oncology 20021201

• Treatment of hypercalcemia of malignancy with bisphosphonates.

  Seminars in oncology 20021201

• [Therapy for hormone-refractory prostate cancer].

  Nihon rinsho. Japanese journal of clinical medicine 20021201

• Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.

  Cancer research 20021115

• Bisphosphonates as adjuvant treatment for breast cancer.

  BMJ (Clinical research ed.) 20021109

• Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders.

  Expert opinion on pharmacotherapy 20021101

• [A questionnaire survey of tolerance and adverse effects of clodronate (Bonefos) in patients with multiple myeloma].

  Vnitrni lekarstvi 20021101

• Bisphosphonates for RSDS and prostate cancer--more benefit then revealed!

  Joint, bone, spine : revue du rhumatisme 20021001

• American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020901

• Clodronate inhibits adrenocortical cell proliferation and P450c21 activity.

  The Journal of endocrinology 20020901

• The absolute bioavailability of clodronate from two different oral doses.

  Bone 20020901

• Bisphosphonates and tumor burden.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801

• Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801

• Bisphosphonates in the treatment of thalassemia-induced osteoporosis.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20020801

• Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits.

  Circulation 20020730

• The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors.

  Bioorganic & medicinal chemistry 20020701

• Skeletal deposition of clodronate is related to parathyroid function and bone turnover in dialysis patients.

  Clinical nephrology 20020701

• Bisphosphonate prodrugs.

  Current medicinal chemistry 20020601

• Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts.

  Journal of endocrinological investigation 20020601

• Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease.

  Human gene therapy 20020520

• Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

  Molecular pharmacology 20020501

• Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.

  American journal of respiratory cell and molecular biology 20020501

• Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway.

  Cancer research 20020501

• Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis.

  Journal of periodontology 20020501

• Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate.

  The British journal of radiology 20020501

• Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?

  British journal of cancer 20020422

• [Macrophage depletion inhibits leukocyte recruitment in experimental melanin-induced uveitis (EMIU)].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20020401

• [Is pamidronate or clodronate better?].

  Vnitrni lekarstvi 20020401

• [Bisphosphonate therapy in Paget disease?].

  Deutsche medizinische Wochenschrift (1946) 20020322

• Reductions in bone mass, structure, and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020301

• Disodium chlodronate prevents bone resorption in experimental periodontitis in rats.

  Journal of periodontology 20020301

• Suppression of immunoreactive macrophages in atheromatous lesions of rabbits by clodronate.

  Pharmacology & toxicology 20020301

• Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies.

  Developmental immunology 20020301

• Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia.

  British journal of haematology 20020201

• Electrospray ionization mass spectrometry and tandem mass spectrometry of clodronate and related bisphosphonate and phosphonate compounds.

  Journal of mass spectrometry : JMS 20020201

• Clodronate in myelofibrosis: a case report.

  The American journal of the medical sciences 20020201

• Bisphosphonate space measurement and dosage requirement for intravenous clodronate treatment of Paget's disease.

  Calcified tissue international 20020201

• The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis.

  Journal of neuroimmunology 20020101

• Does postmenopausal hormone replacement therapy affect cardiac autonomic regulation in osteoporotic women?

  Menopause (New York, N.Y.) 20020101

• Treatment of complex regional pain syndrome type I.

  European journal of pain (London, England) 20020101

• Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.

  Acta orthopaedica Scandinavica 20020101

• Bisphosphonates for the relief of pain secondary to bone metastases.

  The Cochrane database of systematic reviews 20020101

• Liposomes--an invaluable tool in bisphosphonate research.

  Cellular & molecular biology letters 20020101

• Clodronate treatment reduces serum levels of interleukin-6 soluble receptor in Paget's disease of bone.

  Clinical and experimental rheumatology 20020101

• Microstructural properties of bone in rat vertebra after long-term clodronate treatment.

  Journal of bone and mineral metabolism 20020101

• Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate.

  International journal of clinical pharmacology research 20020101

• Bisphosphonate therapy in multiple myeloma: past, present, future.

  European journal of haematology 20020101

• Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat.

  European journal of haematology 20020101

• [The role of adjuvant clodronate therapy for prevention of bone metastasis in breast cancer].

  Magyar onkologia 20020101

• Effects of Cl2MDP-encapsulating liposomes in a murine model of Pseudomonas aeruginosa-induced sepsis.

  Journal of liposome research 20020101

• Clodronate liposomes: perspectives in research and therapeutics.

  Journal of liposome research 20020101

• Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment.

  European journal of cancer (Oxford, England : 1990) 20011201

• [Parenteral disodium-clodronate in patients with rheumatoid arthritis. A two-month open clinical study].

  Minerva medica 20011201

• Effects of long-term administration of clodronate on growing rat bone.

  Calcified tissue international 20011201

• Clinical and biochemical response to single infusion of clodronate in active rheumatoid arthritis--a double blind placebo controlled study.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011201

• Suppression of T cells results in long-term survival of mouse heart xenografts in C6-deficient rats.

  Xenotransplantation 20011101

• The cellular uptake and metabolism of clodronate in RAW 264 macrophages.

  Pharmaceutical research 20011101

• Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis.

  Journal of immunology (Baltimore, Md. : 1950) 20011015

• Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis.

  Journal of immunology (Baltimore, Md. : 1950) 20011001

• Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease.

  Annals of oncology : official journal of the European Society for Medical Oncology 20011001

• Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.

  Glia 20010901

• Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate.

  Rheumatology (Oxford, England) 20010901

• The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.

  Arthritis and rheumatism 20010901

• Long-term release of clodronate from biodegradable microspheres.

  AAPS PharmSciTech 20010901

• Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits.

  Arthritis and rheumatism 20010801

• Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandible.

  International journal of oral and maxillofacial surgery 20010801

• A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.

  Journal of periodontology 20010801

• [Use of clodronic acid in mineral metabolism conditions: state of the art in 2000].

  Minerva medica 20010801

• Bisphosphonates in the prevention of bone metastases: current evidence.

  Seminars in oncology 20010801

• Adjuvant bisphosphonate therapy: the future.

  Seminars in oncology 20010801

• [Bisphosphonates in the treatment of breast carcinoma].

  Polskie Archiwum Medycyny Wewnetrznej 20010801

• Bisphosphonates may be useful in treatment of bone metastases.

  Journal of the National Cancer Institute 20010718

• Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis.

  Experimental eye research 20010701

• [Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases].

  Bulletin du cancer 20010701

• Kupffer cells and neutrophils as paracrine regulators of the heme oxygenase-1 gene in hepatocytes after hemorrhagic shock.

  Shock (Augusta, Ga.) 20010601

• The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro.

  Anti-cancer drugs 20010601

• A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system.

  Journal of neuroimmunology 20010601

• Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma.

  British journal of haematology 20010601

• Induction of proliferation and augmented cytotoxicity of gammadelta T lymphocytes by bisphosphonate clodronate.

  Blood 20010501

• Atypical familial Paget's disease of bone.

  Joint, bone, spine : revue du rhumatisme 20010501

• CD8+ phagocytes in focal ischemia of the rat brain: predominant origin from hematogenous macrophages and targeting to areas of pannecrosis.

  Acta neuropathologica 20010501

• Expression of Th2 cytokines decreases the development of and improves Behçet's disease-like symptoms induced by herpes simplex virus in mice.

  The Journal of infectious diseases 20010415

• Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice.

  Journal of immunology (Baltimore, Md. : 1950) 20010401

• Analgesic effect of bisphosphonates in mice.

  Pain 20010401

• Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line.

  British journal of cancer 20010401

• The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer.

  British journal of cancer 20010401

• Changes in murine bone marrow macrophages and erythroid burst-forming cells following the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP).

  European journal of haematology 20010401

• Bone marrow transplant conditioning intensified with liposomal clodronate to eliminate residual host antigen presenting cells fails to ameliorate GVHD and increases PERI-BMT mortality.

  Transplantation 20010315

• Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages.

  Experimental eye research 20010301

• A mouse model for postoperative fatal enteritis due to Staphylococcus infection.

  The Journal of surgical research 20010301

• Effects of clodronate on vertebral fracture risk in osteoporosis: a 1-year interim analysis.

  Bone 20010301

• An immunomodulatory procedure that stabilizes transgene expression and permits readministration of E1-deleted adenovirus vectors.

  Molecular therapy : the journal of the American Society of Gene Therapy 20010301

• Use of bisphosphonates for the treatment of metastatic bone pain. A survey of palliative physicians in the UK.

  Palliative medicine 20010301

• Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates striatal macrophage invasion and neurodegeneration following local endotoxin infusion in gerbils.

  Brain research 20010216

• Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism.

  Journal of immunology (Baltimore, Md. : 1950) 20010201

• Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells.

  International journal of pharmaceutics 20010201

• A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study.

  Current medicinal chemistry 20010201

• Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation.

  Osteoarthritis and cartilage 20010201

• Treatment of osteoporosis with bisphosphonates.

  Rheumatic diseases clinics of North America 20010201

• The use of bisphosphonate for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer.

  The Journal of urology 20010101

• Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010101

• Bone mineral density in multiple myeloma patients after intravenous clodronate therapy.

  Acta medica Austriaca 20010101

• One-month follow-up of patients treated by intravenous clodronate for acute pain induced by osteoporotic vertebral fracture.

  Drugs under experimental and clinical research 20010101

• Effect of intramuscular clodronate on bone mass and metabolism in osteoporotic women.

  International journal of tissue reactions 20010101

• Reduction of visible bone metastases by clodronate therapy in breast cancer.

  European journal of gynaecological oncology 20010101

• Strategies for management of prostate cancer-related bone pain.

  Drugs & aging 20010101

• [Use of clodronate in the adjuvant treatment of breast cancer is questionable for the time being].

  Duodecim; laaketieteellinen aikakauskirja 20010101

• Bisphosphonates induce breast cancer cell death in vitro.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20001101

• Bisphosphonates induce apoptosis in human breast cancer cell lines.

  British journal of cancer 20000401

• Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation.

  Journal of hepatology 20000101

• Calcitriol-mediated hypercalcaemia and increased interleukins in a patient with sarcoid myopathy.

  Clinical rheumatology 19990101

• Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401

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