2257-09-2 | 2-Phenylethyl isothiocyanate

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$17.00	$12.00
5g	95%	in stock	$34.00	$24.00
25g	95%	in stock	$94.00	$66.00
50g	95%	in stock	$144.00	$101.00
100g	95%	in stock	$257.00	$180.00
500g	95%	in stock	$1,069.00	$748.00

Description

• Catalog Number: AB62931
• Chemical Name: 2-Phenylethyl isothiocyanate
• CAS Number: 2257-09-2
• Molecular Formula: C9H9NS
• Molecular Weight: 163.2395
• MDL Number: MFCD00004821
• SMILES: S=C=NCCc1ccccc1
• NSC Number: 87868

Computed Properties

• Complexity: 144
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 3.5

Literature

• Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.

  Environmental toxicology 20170101

• PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

  Oncotarget 20161115

• Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.

  Toxicology and applied pharmacology 20160415

• Inhibition of crosstalk between Bcr-Abl and PKC signaling by PEITC, augments imatinib sensitivity in chronic myelogenous leukemia cells.

  Chemico-biological interactions 20151205

• Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin.

  Chemical research in toxicology 20141215

• Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

  Neoplasia (New York, N.Y.) 20140901

• Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats.

  Toxicology letters 20130607

• Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells.

  PloS one 20130101

• Time-related survival effects of two gluconasturtiin hydrolysis products on the terrestrial isopod Porcellio scaber.

  Chemosphere 20121101

• Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.

  Analytical biochemistry 20121015

• miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.

  The Prostate 20121001

• Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121001

• Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

  Cell stress & chaperones 20120901

• Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20120901

• Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle.

  Journal of medicinal food 20120901

• Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120901

• Modulation of carcinogen metabolizing cytochromes P450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

  Phytotherapy research : PTR 20120801

• Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.

  Journal of the National Cancer Institute 20120801

• Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.

  The Prostate 20120701

• β-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.

  Oral diseases 20120701

• Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.

  Journal of natural products 20120622

• Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.

  Journal of agricultural and food chemistry 20120606

• Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells.

  Molecular carcinogenesis 20120601

• Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL/Bak interaction.

  Breast cancer research and treatment 20120601

• Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

  Journal of medicinal chemistry 20120524

• Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.

  Ecotoxicology (London, England) 20120501

• First study on antimicriobial activity and synergy between isothiocyanates and antibiotics against selected Gram-negative and Gram-positive pathogenic bacteria from clinical and animal source.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20120501

• Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.

  International journal of oncology 20120401

• Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde.

  The Journal of biological chemistry 20120302

• Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.

  Molecular nutrition & food research 20120301

• Five decades with glutathione and the GSTome.

  The Journal of biological chemistry 20120224

• Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.

  IUBMB life 20120201

• Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Antimicrobial activities of phenethyl isothiocyanate isolated from horseradish.

  Natural product research 20120101

• The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

  Journal of oncology 20120101

• Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish.

  PloS one 20120101

• A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer.

  Journal of clinical bioinformatics 20120101

• Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells.

  PloS one 20120101

• Astroglial pentose phosphate pathway rates in response to high-glucose environments.

  ASN neuro 20120101

• Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death.

  PloS one 20120101

• Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells.

  PloS one 20120101

• Towards the understanding of microRNA and environmental factor interactions and their relationships to human diseases.

  Scientific reports 20120101

• Modeling effective dosages in hormetic dose-response studies.

  PloS one 20120101

• Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Current and future options for the management of phantom-limb pain.

  Journal of pain research 20120101

• Cigarette smoke exposure-associated alterations to non-coding RNA.

  Frontiers in genetics 20120101

• Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.

  PloS one 20120101

• Turning the 'mustard oil bomb' into a 'cyanide bomb': aromatic glucosinolate metabolism in a specialist insect herbivore.

  PloS one 20120101

• Sulforaphane potentiates RNA damage induced by different xenobiotics.

  PloS one 20120101

• A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells.

  Oxidative medicine and cellular longevity 20120101

• Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.

  PloS one 20120101

• Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures.

  Journal of ovarian research 20120101

• Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.

  BMC medicine 20120101

• Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

  PloS one 20120101

• Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats.

  The journal of medical investigation : JMI 20120101

• Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity.

  Antioxidants & redox signaling 20111215

• Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.

  Mutation research 20111201

• Cancer chemoprevention by targeting the epigenome.

  Current drug targets 20111201

• Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes.

  International journal of obesity (2005) 20111201

• Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.

  The British journal of nutrition 20111201

• NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.

  Oncogene 20111110

• Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.

  Journal of Korean medical science 20111101

• Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

  Clinical epigenetics 20111026

• Identification of potential protein targets of isothiocyanates by proteomics.

  Chemical research in toxicology 20111017

• Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

  Molecular nutrition & food research 20111001

• Inorganic sulfur reduces the motility and invasion of MDA-MB-231 human breast cancer cells.

  Nutrition research and practice 20111001

• Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

  The Journal of biological chemistry 20110923

• The expression of the pro-apoptotic gene Air is inducible in human pancreatic adenocarcinoma cells.

  Journal of cellular physiology 20110901

• Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5.

  Journal of agricultural and food chemistry 20110810

• Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.

  Archives of toxicology 20110801

• Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110801

• Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.

  Bioorganic & medicinal chemistry letters 20110801

• Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma.

  Haematologica 20110801

• Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

  Nature 20110714

• In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.

  Pest management science 20110701

• Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

  Biopharmaceutics & drug disposition 20110701

• Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.

  Anticancer research 20110501

• [Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats].

  Wei sheng yan jiu = Journal of hygiene research 20110501

• Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

  Journal of the National Cancer Institute 20110406

• Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin.

  Journal of medicinal food 20110401

• Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

  Cell death & disease 20110401

• Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

  The British journal of nutrition 20110301

• Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.

  Pharmacological research 20110301

• Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

  Journal of medicinal chemistry 20110210

• Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

  Carcinogenesis 20110201

• Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.

  Nutrition and cancer 20110101

• [Changes on neurobehavioral development of the offspring in rats prenataly exposed by phenethyl isothiocyanate].

  Wei sheng yan jiu = Journal of hygiene research 20110101

• Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.

  Molecular medicine reports 20110101

• NNK-Induced Lung Tumors: A Review of Animal Model.

  Journal of oncology 20110101

• Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

  Molecular cancer 20110101

• The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

  PloS one 20110101

• Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.

  BMC cancer 20110101

• Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.

  Bioscience, biotechnology, and biochemistry 20110101

• Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

  Journal of biomedicine & biotechnology 20110101

• Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

  PloS one 20110101

• Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.

  Chinese medicine 20110101

• Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.

  PloS one 20110101

• Mitochondrial peroxiredoxin III is a potential target for cancer therapy.

  International journal of molecular sciences 20110101

• Selenium and lung cancer: a systematic review and meta analysis.

  PloS one 20110101

• Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

  Clinical epigenetics 20110101

• Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.

  Molecular nutrition & food research 20101201

• Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes.

  Pharmaceutical research 20101201

• Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.

  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201

• In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study.

  The British journal of nutrition 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: insights from PyMT transgenic mouse model.

  Oncology reports 20101101

• Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate.

  Blood 20101014

• Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.

  Archives of toxicology 20101001

• Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.

  Molecular nutrition & food research 20101001

• Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment.

  PLoS medicine 20101001

• Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages.

  Molecular nutrition & food research 20100901

• Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review).

  International journal of oncology 20100901

• Identification of biologically relevant compounds in aboveground and belowground induced volatile blends.

  Journal of chemical ecology 20100901

• Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20100901

• Evaluation of antibacterial activity of 3-butenyl, 4-pentenyl, 2-phenylethyl, and benzyl isothiocyanate in Brassica vegetables.

  Journal of food science 20100901

• Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.

  The Journal of biological chemistry 20100820

• A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.

  Journal of molecular biology 20100820

• Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.

  Chemical research in toxicology 20100816

• Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.

  Toxicological sciences : an official journal of the Society of Toxicology 20100801

• Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

  The Journal of nutrition 20100801

• Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

  Journal of medicinal chemistry 20100722

• Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

  Journal of cellular and molecular medicine 20100601

• Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

• Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways.

  Anticancer research 20100601

• Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.

  Chemical research in toxicology 20100517

• Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

  Carcinogenesis 20100501

• Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung.

  Carcinogenesis 20100501

• Formation and distribution of NNK metabolites in an isolated perfused rat lung.

  Drug metabolism and disposition: the biological fate of chemicals 20100501

• Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.

  International journal of food sciences and nutrition 20100501

• Antimicrobial activity of phenolics and glucosinolate hydrolysis products and their synergy with streptomycin against pathogenic bacteria.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20100501

• New biomarkers for monitoring the levels of isothiocyanates in humans.

  Chemical research in toxicology 20100419

• Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.

  Bioorganic & medicinal chemistry letters 20100415

• p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

  Cancer research 20100415

• Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo.

  Pharmaceutical research 20100401

• 6-Chloro-3-phenethyl-2-thioxo-2,3-di-hydro-quinazolin-4(1H)-one.

  Acta crystallographica. Section E, Structure reports online 20100401

• Phytochemicals in cancer prevention and therapy: truth or dare?

  Toxins 20100401

• Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.

  Toxins 20100401

• Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin.

  FEBS letters 20100319

• Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.

  International journal of cancer 20100301

• Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats.

  Molecular nutrition & food research 20100301

• Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.

  The AAPS journal 20100301

• Paradoxical roles for antioxidants in tumor prevention and eradication.

  Cancer biology & therapy 20100301

• Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A.

  Current cancer drug targets 20100301

• Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.

  Toxicology 20100209

• Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.

  Cancer prevention research (Philadelphia, Pa.) 20100101

• A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

  Arthritis research & therapy 20100101

• Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.

  Bioscience, biotechnology, and biochemistry 20100101

• Oxidative stress in NSC-741909-induced apoptosis of cancer cells.

  Journal of translational medicine 20100101

• Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.

  Mediators of inflammation 20100101

• Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

  BMC cancer 20100101

• Dietary phenethylisothiocyanate attenuates bowel inflammation in mice.

  BMC chemical biology 20100101

• Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.

  BMC cancer 20100101

• Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

  PloS one 20100101

• Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

  Journal of molecular signaling 20100101

• Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

  PloS one 20100101

• Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling.

  PloS one 20100101

• Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.

  Chinese medicine 20100101

• Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells.

  PloS one 20100101

• Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.

  PloS one 20100101

• Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.

  Journal of hematology & oncology 20100101

• Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment.

  Toxins 20100101

• Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells.

  European journal of nutrition 20091201

• Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.

  The Journal of biological chemistry 20091120

• Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

  Biochemical and biophysical research communications 20091016

• Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.

  Molecular and cellular biochemistry 20091001

• Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria.

  Journal of food science 20091001

• Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

  Biochemical pharmacology 20090801

• Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells.

  Molecular nutrition & food research 20090701

• Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

  The Journal of biological chemistry 20090619

• Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria.

  Journal of applied microbiology 20090601

• Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice.

  Cancer prevention research (Philadelphia, Pa.) 20090601

• Antimutagenic effect of phenethyl isothiocyanate.

  Central European journal of public health 20090601

• Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.

  Chemico-biological interactions 20090515

• Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.

  Cancer research 20090415

• Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.

  Experimental biology and medicine (Maywood, N.J.) 20090301

• [Natural compounds in chemoprevention of esophageal squamous cell tumors--experimental studies].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090201

• Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.

  Pharmaceutical research 20090101

• Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

  Cell biology international 20090101

• Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.

  Oncology reports 20090101

• Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L.

  Foodborne pathogens and disease 20090101

• Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.

  BMC gastroenterology 20090101

• Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.

  PloS one 20090101

• Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

  Cancer cell international 20090101

• Differing mechanisms of simple nitrile formation on glucosinolate degradation in Lepidium sativum and Nasturtium officinale seeds.

  Phytochemistry 20090101

• Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.

  PloS one 20090101

• Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis.

  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101

• Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

  British journal of cancer 20081209

• Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke.

  Current cancer drug targets 20081201

• Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells.

  Archives of pharmacal research 20081201

• Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL.

  Cancer letters 20081128

• Development of chitosan-SLN microparticles for chemotherapy: in vitro approach through efflux-transporter modulation.

  Journal of controlled release : official journal of the Controlled Release Society 20081112

• Acaricidal constituents isolated from Sinapis alba L. seeds and structure-activity relationships.

  Journal of agricultural and food chemistry 20081112

• Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.

  Journal of natural products 20081101

• [Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro].

  Wei sheng yan jiu = Journal of hygiene research 20081101

• Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

  Diabetes 20081001

• Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

  Planta medica 20081001

• Genetic networks controlling structural outcome of glucosinolate activation across development.

  PLoS genetics 20081001

• Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.

  Pharmaceutical research 20080901

• Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

  Blood 20080901

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.

  Free radical biology & medicine 20080815

• De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc.

  International journal of oncology 20080801

• Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.

  Cancer research 20080801

• Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.

  Leukemia 20080601

• PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.

  The AAPS journal 20080601

• Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).

  Molecular carcinogenesis 20080501

• Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production.

  Synapse (New York, N.Y.) 20080501

• Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20080301

• Herbal compounds and toxins modulating TRP channels.

  Current neuropharmacology 20080301

• Barbarea vulgaris glucosinolate phenotypes differentially affect performance and preference of two different species of lepidopteran herbivores.

  Journal of chemical ecology 20080201

• Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

  PloS one 20080101

• Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

  Nutrition and cancer 20080101

• Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

  Chinese medicine 20080101

• Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context.

  Molecular cancer 20080101

• Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

  Biological chemistry 20071001

• The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

  Cancer research 20070701

• Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus.

  Cancer research 20070701

• Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.

  The Prostate 20070601

• Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.

  Cancer biology & therapy 20070501

• Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

  Cancer research 20070415

• Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments.

  Journal of agricultural and food chemistry 20070321

• Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo.

  Cancer research 20070301

• Does the consumption of green tea reduce the risk of lung cancer among smokers?

  Evidence-based complementary and alternative medicine : eCAM 20070301

• Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer.

  Molecular carcinogenesis 20070101

• Polymeric nanoparticle-encapsulated curcumin ('nanocurcumin'): a novel strategy for human cancer therapy.

  Journal of nanobiotechnology 20070101

• Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.

  BMC cancer 20070101

• The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.

  BMC cancer 20070101

• CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity.

  Journal of neural transmission. Supplementum 20070101

• Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.

  BioFactors (Oxford, England) 20070101

• Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.

  BioFactors (Oxford, England) 20070101

• Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells.

  The Journal of nutritional biochemistry 20061201

• Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations.

  British journal of cancer 20061120

• Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

  Carcinogenesis 20061101

• Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.

  Life sciences 20061012

• Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation.

  Gynecologic oncology 20061001

• Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.

  Carcinogenesis 20061001

• Enzymatic mechanisms of ethanol oxidation in the brain.

  Alcoholism, clinical and experimental research 20060901

• Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

  Cancer cell 20060901

• c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.

  Molecular carcinogenesis 20060801

• Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

  Molecular cancer therapeutics 20060801

• Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.

  Mutation research 20060725

• Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2.

  Cancer research 20060701

• Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest.

  International immunopharmacology 20060501

• Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.

  Carcinogenesis 20060401

• In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate.

  The Journal of pharmacology and experimental therapeutics 20060401

• Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.

  Cancer research 20060401

• Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.

  Journal of agricultural and food chemistry 20060308

• ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

  Carcinogenesis 20060301

• Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

  Carcinogenesis 20060301

• The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.

  Anti-cancer drugs 20060301

• Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.

  Carcinogenesis 20060201

• Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

  Cancer research 20060115

• Current trends and perspectives in nutrition and cancer prevention.

  Neoplasma 20060101

• Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene.

  BMC cancer 20060101

• Modest induction of phase 2 enzyme activity in the F-344 rat prostate.

  BMC cancer 20060101

• Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats.

  Nutrition and cancer 20060101

• Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20060101

• Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.

  Journal of ethnobiology and ethnomedicine 20060101

• Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.

  Journal of neural transmission. Supplementum 20060101

• Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

  Journal of applied toxicology : JAT 20060101

• Modulation of multigene expression and proteome profiles by chemopreventive agents.

  Mutation research 20051211

• Modulation of apoptosis by cancer chemopreventive agents.

  Mutation research 20051211

• The time-dependent effect of gluconasturtiin and phenethyl isothiocyanate on metabolic and antioxidative parameters in rats.

  Journal of animal physiology and animal nutrition 20051201

• Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats.

  Toxicology 20051115

• Biofumigation: environmental impacts on the biological activity of diverse pure and plant-derived isothiocyanates.

  Pest management science 20051101

• Pharmacokinetics of dietary phenethyl isothiocyanate in rats.

  Pharmaceutical research 20051001

• Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

  Current drug metabolism 20051001

• N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

  Cancer research 20050915

• Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

  Cancer research 20050915

• Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate.

  Archives of toxicology 20050901

• The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050901

• Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.

  European journal of pharmacology 20050822

• Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein.

  Biochemical pharmacology 20050815

• Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.

  World journal of gastroenterology 20050714

• Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

  Molecular carcinogenesis 20050701

• Induction of glutathione S-transferase and glutathione by toxic compounds and elicitors in reed canary grass.

  Biotechnology letters 20050701

• Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

  Oncogene 20050630

• Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.

  Nitric oxide : biology and chemistry 20050601

• Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

• Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion.

  Toxicology letters 20050315

• Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model.

  Cancer letters 20050310

• beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.

  Proteomics 20050301

• Induction of phase I, II and III drug metabolism/transport by xenobiotics.

  Archives of pharmacal research 20050301

• Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

  The international journal of biochemistry & cell biology 20050101

• Animal models and analytical approaches for understanding the relationships between wine and cancer.

  Drugs under experimental and clinical research 20050101

• Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein).

  Molecular pharmaceutics 20050101

• Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport.

  Pharmaceutical research 20041201

• Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

• Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

  Journal of neurochemistry 20041001

• Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

  Experimental biology and medicine (Maywood, N.J.) 20040901

• Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest.

  Carcinogenesis 20040801

• Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.

  Journal of pharmaceutical sciences 20040701

• Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

  Xenobiotica; the fate of foreign compounds in biological systems 20040701

• Potent chemopreventive agents against pancreatic cancer.

  Current cancer drug targets 20040601

• Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells.

  The Journal of pharmacology and experimental therapeutics 20040501

• The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.

  Carcinogenesis 20040501

• Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

  Molecular cancer therapeutics 20040501

• Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.

  Pharmaceutical research 20040401

• Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.

  Pharmaceutical research 20040401

• Genetic and metabolic effects of gluconasturtiin, a glucosinolate derived from cruciferae.

  Mutation research 20040112

• Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040101

• Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

  Anticancer research 20040101

• Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.

  Nutrition and cancer 20040101

• Toxicological assessment of noxious inhalants.

  GMS current topics in otorhinolaryngology, head and neck surgery 20040101

• Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model for study of oral cancer chemoprevention.

  Cancer letters 20031230

• Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells.

  Journal of cellular biochemistry 20031215

• Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry.

  Analytical biochemistry 20031201

• Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).

  Pharmaceutical research 20030901

• Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein.

  The Journal of pharmacy and pharmacology 20030901

• Ontogenic variations of ascorbic acid and phenethyl isothiocyanate concentrations in watercress (Nasturtium officinale R.Br.) leaves.

  Journal of agricultural and food chemistry 20030827

• The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

  Carcinogenesis 20030801

• [Effects of ursolic acid on liver-protection and bile secretion].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030801

• beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

  Cellular and molecular life sciences : CMLS 20030701

• Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

  Biochimica et biophysica acta 20030626

• Sensitivity of Meloidogyne javanica and Tylenchulus semipenetrans to Isothiocyanates in Laboratory Assays.

  Phytopathology 20030601

• Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.

  Carcinogenesis 20030301

• Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.

  Carcinogenesis 20030301

• Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.

  Chemico-biological interactions 20030106

• Mechanism-based in vitro screening of potential cancer chemopreventive agents.

  Mutation research 20030101

• Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.

  Mutation research 20030101

• Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.

  Toxicologic pathology 20030101

• An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: a new approach in the search for transmitter metabolites.

  Neuroscience 20030101

• Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes.

  Nutrition and cancer 20030101

• Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.

  The Journal of biological chemistry 20021018

• In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.

  Cancer letters 20021008

• Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

  Pharmaceutical research 20021001

• Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster.

  Toxicology 20020930

• Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

  Carcinogenesis 20020901

• Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.

  Carcinogenesis 20020901

• Rapid in vivo assay for topical oral cancer chemopreventive agents.

  International journal of oncology 20020701

• Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

  Cancer research 20020701

• The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

  Pharmaceutical research 20020701

• Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.

  The Journal of biological chemistry 20020510

• Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.

  Carcinogenesis 20020201

• [Determination of isothiocyanates and related compounds in mustard extract and horseradish extract used as natural food additives].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020201

• Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators.

  The Biochemical journal 20020115

• Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.

  Cancer research 20020101

• 4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).

  Journal of agricultural and food chemistry 20011201

• Barbarea verna as a source of 2-phenylethyl glucosinolate, precursor of cancer chemopreventive phenylethyl isothiocyanate.

  Fitoterapia 20011101

• Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

  Chemical research in toxicology 20010901

• Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

  Cancer research 20010815

• Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

  Drug metabolism and disposition: the biological fate of chemicals 20010801

• Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.

  Mutation research 20010725

• Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.

  Archives of biochemistry and biophysics 20010701

• Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

  Synapse (New York, N.Y.) 20010615

• Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control.

  Toxicological sciences : an official journal of the Society of Toxicology 20010601

• Consumption of watercress fails to alter coumarin metabolism in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.

  Analytical biochemistry 20010415

• Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.

  Cancer research 20010315

• Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.

  British journal of cancer 20010301

• Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.

  Carcinogenesis 20010301

• Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro.

  Biochemical pharmacology 20010115

• Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.

  Cancer letters 20010110

• Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.

  Medical hypotheses 20010101

• Inhibition of carcinogenesis and toxicity by dietary constituents.

  Advances in experimental medicine and biology 20010101

• Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

  Drug metabolism reviews 20010101

• Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia.

  In vitro & molecular toxicology 20010101

• Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.

  Nutrition and cancer 20010101

• Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

  Biochemical pharmacology 20000715

• Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

  Journal of toxicology and environmental health. Part A 19991210

• Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.

  Carcinogenesis 19981101

• Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

  Cancer research 19980201

• Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.

  Carcinogenesis 19970901

• Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.

  International journal of cancer 19970703

• Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).

  Carcinogenesis 19951201

• Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor.

  The Journal of pharmacology and experimental therapeutics 19951001

• Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions.

  European journal of biochemistry 19950615

• Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.

  Biochemical and biophysical research communications 19950117