22994-85-0 | Benznidazole

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$11.00	$8.00
5mg	95%	in stock	$24.00	$17.00
100mg	97%	in stock	$351.00	$246.00

Description

• Catalog Number: AB21368
• Chemical Name: Benznidazole
• CAS Number: 22994-85-0
• Molecular Formula: C12H12N4O3
• Molecular Weight: 260.2487
• MDL Number: MFCD00243089
• SMILES: O=C(Cn1ccnc1[N+](=O)[O-])NCc1ccccc1
• NSC Number: 299972

Computed Properties

• Complexity: 325
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 0.9

Literature

• Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages.

  Chemico-biological interactions 20171101

• Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice.

  Antimicrobial agents and chemotherapy 20170401

• Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis.

  Toxicology and applied pharmacology 20170115

• Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas Disease.

  Antimicrobial agents and chemotherapy 20161201

• The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).

  Toxicology and applied pharmacology 20160801

• Tolerance of benznidazole in a United States Chagas Disease clinic.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150415

• Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.

  PLoS neglected tropical diseases 20141001

• Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi.

  Environmental and molecular mutagenesis 20140501

• Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents.

  European journal of medicinal chemistry 20131101

• Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

  Journal of medicinal chemistry 20130926

• Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

  Journal of medicinal chemistry 20130711

• Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.

  Journal of medicinal chemistry 20130227

• Nuclease activity and ultrastructural effects of new sulfonamides with anti-leishmanial and trypanocidal activities.

  Parasitology international 20121201

• Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.

  Bioorganic & medicinal chemistry 20121101

• Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites.

  The American journal of tropical medicine and hygiene 20121003

• Copper(II)-fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20121001

• Liver transplantation using Chagas-infected donors in uninfected recipients: a single-center experience without prophylactic therapy.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20121001

• Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions.

  Brain, behavior, and immunity 20121001

• Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20121001

• 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

  Bioorganic & medicinal chemistry letters 20121001

• In vitro and in vivo studies of the trypanocidal activity of four terpenoid derivatives against Trypanosoma cruzi.

  The American journal of tropical medicine and hygiene 20120905

• Benznidazole shortage makes chagas disease a neglected tropical disease in developed countries: data from Spain.

  The American journal of tropical medicine and hygiene 20120905

• Taiwaniaquinoid and abietane quinone derivatives with trypanocidal activity against T. cruzi and Leishmania spp.

  Parasitology international 20120901

• Antiparasitical chemotherapy in Chagas' disease cardiomyopathy: current evidence.

  Tropical medicine & international health : TM & IH 20120901

• Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents.

  European journal of medicinal chemistry 20120901

• Apis mellifera venom induces different cell death pathways in Trypanosoma cruzi.

  Parasitology 20120901

• New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

  Bioorganic & medicinal chemistry 20120815

• Skin lesions, malaise, and heart failure in a renal transplant recipient.

  Transplant infectious disease : an official journal of the Transplantation Society 20120801

• Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease.

  The Journal of antimicrobial chemotherapy 20120801

• Chagas disease in the immunosuppressed host.

  Current opinion in infectious diseases 20120801

• Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents.

  European journal of medicinal chemistry 20120801

• Posttherapeutic cure criteria in Chagas' disease: conventional serology followed by supplementary serological, parasitological, and molecular tests.

  Clinical and vaccine immunology : CVI 20120801

• Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.

  The Journal of infectious diseases 20120715

• [A clinical and epidemiological study of the Trypanosoma cruzi infected population in the north metropolitan area of Barcelona].

  Revista clinica espanola 20120701

• Reactivation of Chagas' disease: cutaneous manifestations in two immunosuppressed patients.

  International journal of dermatology 20120701

• Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.

  Journal of medicinal chemistry 20120614

• On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.

  European journal of medicinal chemistry 20120601

• American trypanosomiasis (Chagas disease).

  Infectious disease clinics of North America 20120601

• The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.

  Memorias do Instituto Oswaldo Cruz 20120601

• Antiprotozoal sesquiterpene pyridine alkaloids from Maytenus ilicifolia.

  Journal of natural products 20120525

• In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease.

  Journal of medicinal chemistry 20120510

• Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

  Journal of medicinal chemistry 20120510

• Safety of benznidazole use in the treatment of chronic Chagas' disease.

  The Journal of antimicrobial chemotherapy 20120501

• In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms.

  Experimental parasitology 20120501

• Inducible nitric oxide synthase in heart tissue and nitric oxide in serum of Trypanosoma cruzi-infected rhesus monkeys: association with heart injury.

  PLoS neglected tropical diseases 20120501

• Chagas disease: 'the new HIV/AIDS of the Americas'.

  PLoS neglected tropical diseases 20120501

• Genetic characterization of Trypanosoma cruzi DTUs in wild Triatoma infestans from Bolivia: predominance of TcI.

  PLoS neglected tropical diseases 20120501

• Identification of benzoylisoquinolines as potential anti-Chagas agents.

  Bioorganic & medicinal chemistry 20120415

• Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.

  Journal of medicinal chemistry 20120412

• In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi.

  Acta tropica 20120401

• CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy.

  PLoS pathogens 20120401

• Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.

  PLoS neglected tropical diseases 20120401

• First century of Chagas' disease: an overview on novel approaches to nifurtimox and benzonidazole delivery systems.

  Journal of pharmaceutical sciences 20120301

• Supply chain problems for Chagas disease treatment.

  The Lancet. Infectious diseases 20120301

• Nifurtimox chemotherapy: collateral effects in treated Trypanosoma cruzi infected patients.

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20120301

• [The effect of the essential oil from Aloysia triphylla britton (lemon verbena) on Trypanosoma cruzi in mice].

  Revista peruana de medicina experimental y salud publica 20120301

• Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.

  Bioorganic & medicinal chemistry 20120215

• Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles.

  European journal of medicinal chemistry 20120201

• Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae).

  Parasitology research 20120101

• Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase.

  Bioorganic & medicinal chemistry 20120101

• Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.

  PLoS pathogens 20120101

• Proteomic analysis of Trypanosoma cruzi epimastigotes subjected to heat shock.

  Journal of biomedicine & biotechnology 20120101

• In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.

  PloS one 20120101

• Dynamics of Lymphocyte Populations during Trypanosoma cruzi Infection: From Thymocyte Depletion to Differential Cell Expansion/Contraction in Peripheral Lymphoid Organs.

  Journal of tropical medicine 20120101

• The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model.

  Journal of biomedical science 20120101

• Therapy of chagas disease: implications for levels of prevention.

  Journal of tropical medicine 20120101

• Advanced megaesophagus (Group III) secondary to vector-borne Chagas disease in a 20-month-old infant.

  Revista da Sociedade Brasileira de Medicina Tropical 20120101

• Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease.

  PloS one 20120101

• Leishmanicidal activity of nine novel flavonoids from Delphinium staphisagria.

  TheScientificWorldJournal 20120101

• Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi.

  Parasites & vectors 20120101

• Pyrogallol red oxidation induced by superoxide radicals: application to evaluate redox cycling of nitro compounds.

  Analytical biochemistry 20111215

• Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.

  Bioorganic & medicinal chemistry 20111215

• Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.

  Journal of medicinal chemistry 20111208

• Evaluation of thiosemicarbazones and semicarbazones as potential agents anti-Trypanosoma cruzi.

  Experimental parasitology 20111201

• Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.

  PLoS neglected tropical diseases 20111201

• Parasitic infections in HIV infected individuals: diagnostic & therapeutic challenges.

  The Indian journal of medical research 20111201

• Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

  Bioorganic & medicinal chemistry letters 20111101

• Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents.

  Bioorganic & medicinal chemistry 20111101

• In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species.

  Natural product communications 20111101

• Update in treatment of Chagas disease.

  Current opinion in infectious diseases 20111001

• Hypercoagulability biomarkers in Trypanosoma cruzi -infected patients.

  Thrombosis and haemostasis 20111001

• Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.

  Bioorganic & medicinal chemistry letters 20111001

• Congenital Chagas disease: recommendations for diagnosis, treatment and control of newborns, siblings and pregnant women.

  PLoS neglected tropical diseases 20111001

• Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum.

  Journal of natural products 20110923

• The current screening programme for congenital transmission of Chagas disease in Catalonia, Spain.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20110922

• [Human immunodeficiency virus and Chagas disease coinfection treated successfully with benznidazole and a raltegravir-based antiretroviral regimen: a case report].

  Medicina clinica 20110910

• Synthesis, trypanocidal activity and molecular modeling studies of 2-alkylaminomethylquinoline derivatives.

  European journal of medicinal chemistry 20110901

• The Trypanosoma cruzi protease cruzain mediates immune evasion.

  PLoS pathogens 20110901

• Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease.

  PLoS neglected tropical diseases 20110901

• Retracing micro-epidemics of Chagas disease using epicenter regression.

  PLoS computational biology 20110901

• Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country.

  Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20110901

• Chronic phase of Chagas disease: why should it be treated? A comprehensive review.

  Memorias do Instituto Oswaldo Cruz 20110901

• Trypanosoma cruzi: evaluation of (-)-cubebin derivatives activity in the messenger RNAs processing.

  Parasitology research 20110801

• Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection.

  International immunopharmacology 20110801

• Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

• The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

  PLoS neglected tropical diseases 20110801

• Real-time PCR in HIV/Trypanosoma cruzi coinfection with and without Chagas disease reactivation: association with HIV viral load and CD4 level.

  PLoS neglected tropical diseases 20110801

• Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening.

  PLoS neglected tropical diseases 20110801

• The use of IgG antibodies in conventional and non-conventional immunodiagnostic tests for early prognosis after treatment of Chagas disease.

  Journal of immunological methods 20110729

• Chagas disease in Latin American migrants: a Spanish challenge.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110701

• Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues.

  European journal of medicinal chemistry 20110701

• Antitrypanosomal therapy for chronic Chagas' disease.

  The New England journal of medicine 20110630

• In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi.

  The Journal of antimicrobial chemotherapy 20110601

• The use of solid dispersion systems in hydrophilic carriers to increase benzonidazole solubility.

  Journal of pharmaceutical sciences 20110601

• In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.

  Journal of inorganic biochemistry 20110601

• Neuronal changes caused by Trypanosoma cruzi: an experimental model.

  Anais da Academia Brasileira de Ciencias 20110601

• Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome.

  PLoS neglected tropical diseases 20110601

• I Latin American Guidelines for the diagnosis and treatment of Chagas' heart disease: executive summary.

  Arquivos brasileiros de cardiologia 20110601

• Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.

  Bioorganic & medicinal chemistry letters 20110515

• Target validation: linking target and chemical properties to desired product profile.

  Current topics in medicinal chemistry 20110501

• Mining a cathepsin inhibitor library for new antiparasitic drug leads.

  PLoS neglected tropical diseases 20110501

• Current status of Chagas disease chemotherapy.

  Expert review of anti-infective therapy 20110501

• Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.

  Journal of natural products 20110425

• In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease.

  Journal of natural products 20110425

• Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

  The Journal of biological chemistry 20110415

• Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage.

  The American journal of tropical medicine and hygiene 20110405

• Chagas disease among the Latin American adult population attending in a primary care center in Barcelona, Spain.

  PLoS neglected tropical diseases 20110401

• Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.

  Molecular and biochemical parasitology 20110301

• Benznidazole treatment attenuates liver NF-κB activity and MAPK in a cecal ligation and puncture model of sepsis.

  Molecular immunology 20110301

• Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi.

  PLoS neglected tropical diseases 20110301

• In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease.

  Journal of medicinal chemistry 20110224

• Zanthoxylum chiloperone leaves extract: first sustainable Chagas disease treatment.

  Journal of ethnopharmacology 20110216

• A Latin American man with palpitations, dizziness, episodes of nonsustained ventricular tachycardia, and an apical aneurysm.

  PLoS neglected tropical diseases 20110201

• Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion.

  PLoS neglected tropical diseases 20110201

• [Update on the treatment of Chagas' disease].

  Revista medica de Chile 20110201

• Brazilian Green Propolis: Effects In Vitro and In Vivo on Trypanosoma cruzi.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• A high-performance liquid chromatographic method for benznidazole quantitation in plasma of patients with Chagas disease.

  Clinical chemistry and laboratory medicine 20110101

• Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease.

  Current medicinal chemistry 20110101

• Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi.

  Journal of synchrotron radiation 20110101

• Adverse events after the use of benznidazole in infants and children with Chagas disease.

  Pediatrics 20110101

• [Clinical and radiological evaluation of the esophagus and colon in the acute phase of Chagas disease with Report of three cases of spontaneous remission of esophageal group I aperistalsis].

  Revista da Sociedade Brasileira de Medicina Tropical 20110101

• [Chagas disease in Mexico. Report of two acute cases].

  Gaceta medica de Mexico 20110101

• Mitochondrial dysfunction in Trypanosoma cruzi: the role of Serratia marcescens prodigiosin in the alternative treatment of Chagas disease.

  Parasites & vectors 20110101

• Nutritional Status Driving Infection by Trypanosoma cruzi: Lessons from Experimental Animals.

  Journal of tropical medicine 20110101

• Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

  Current topics in medicinal chemistry 20110101

• Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection.

  PloS one 20110101

• Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies.

  The open medicinal chemistry journal 20110101

• The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi.

  Enzyme research 20110101

• Antiprotozoal activities of organic extracts from French marine seaweeds.

  Marine drugs 20110101

• Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies.

  PloS one 20110101

• Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.

  BMC infectious diseases 20110101

• Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.

  PloS one 20110101

• Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi.

  Parasites & vectors 20110101

• The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi.

  Journal of parasitology research 20110101

• Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS.

  PloS one 20110101

• 3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease.

  PloS one 20110101

• Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children.

  PloS one 20110101

• Glucose-6-phosphate dehydrogenase of trypanosomatids: characterization, target validation, and drug discovery.

  Molecular biology international 20110101

• Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.

  Molecular biology international 20110101

• Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010).

  Revista da Sociedade Brasileira de Medicina Tropical 20110101

• Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

• Heart rate variability in chronic Chagas patients before and after treatment with benznidazole.

  Autonomic neuroscience : basic & clinical 20101208

• Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains.

  Immunobiology 20101201

• Canova medication modifies parasitological parameters in mice infected with Trypanosoma cruzi.

  Experimental parasitology 20101201

• High antitrypanosomal activity of plant-derived sulphur-containing amides.

  International journal of antimicrobial agents 20101201

• Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.

  European journal of medicinal chemistry 20101201

• [Chagas' disease as a cause of cerebral mass in a patient with lymphoblastic leukemia in remission].

  Archivos argentinos de pediatria 20101201

• The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America.

  PLoS neglected tropical diseases 20101201

• Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

  Biochemical pharmacology 20101115

• Tolerance and safety of nifurtimox in patients with chronic chagas disease.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101115

• Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.

  Bioorganic & medicinal chemistry 20101115

• Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.

  Bioorganic & medicinal chemistry 20101115

• Antioxidant therapy attenuates oxidative insult caused by benzonidazole in chronic Chagas' heart disease.

  International journal of cardiology 20101105

• QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.

  European journal of medicinal chemistry 20101101

• 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

  Bioorganic & medicinal chemistry 20101101

• Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease.

  Memorias do Instituto Oswaldo Cruz 20101101

• The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice.

  Memorias do Instituto Oswaldo Cruz 20101101

• Chagas cardiomyopathy manifestations and Trypanosoma cruzi genotypes circulating in chronic Chagasic patients.

  PLoS neglected tropical diseases 20101101

• Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue.

  Human & experimental toxicology 20101001

• Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs.

  Experimental parasitology 20101001

• Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi.

  Parasitology research 20101001

• Antitrypanosomal agents: treatment or threat?

  Lancet (London, England) 20100904

• Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.

  European journal of medicinal chemistry 20100901

• Benznidazole blocks NF-kappaB activation but not AP-1 through inhibition of IKK.

  Molecular immunology 20100901

• Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas.

  Bioorganic & medicinal chemistry 20100901

• A preformulation study of a new medicine for Chagas disease treatment: physicochemical characterization, thermal stability, and compatibility of benznidazole.

  AAPS PharmSciTech 20100901

• In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

  PLoS neglected tropical diseases 20100901

• Congenital infections with Trypanosoma cruzi or Toxoplasma gondii are associated with decreased serum concentrations of interferon-γ and interleukin-18 but increased concentrations of interleukin-10.

  Annals of tropical medicine and parasitology 20100901

• Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi.

  PLoS pathogens 20100901

• Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.

  Journal of natural products 20100827

• Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones.

  Parasitology research 20100801

• Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-disease-endemic country.

  The Journal of antimicrobial chemotherapy 20100801

• Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease.

  Redox report : communications in free radical research 20100801

• Chagas disease: changes in knowledge and management.

  The Lancet. Infectious diseases 20100801

• A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.

  International journal of antimicrobial agents 20100701

• In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.

  PLoS neglected tropical diseases 20100701

• Chagas disease: pushing through the pipeline.

  Nature 20100624

• Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

  Biochemical pharmacology 20100615

• Naftifine-analogues as anti-Trypanosoma cruzi agents.

  European journal of medicinal chemistry 20100601

• Acute Chagas' disease in postrenal transplant and treatment with benzonidazole.

  Annals of diagnostic pathology 20100601

• Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.

  Journal of the American College of Cardiology 20100601

• Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.

  PLoS neglected tropical diseases 20100601

• The centennial of the discovery of Chagas disease: facing the current challenges.

  PLoS neglected tropical diseases 20100601

• Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity.

  British journal of pharmacology 20100501

• Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.

  British journal of pharmacology 20100501

• New method for quantification of Trypanosoma cruzi in animal's tissue in the chronic phase of experimental Chagas' disease.

  Parasitology research 20100501

• The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles.

  Bioorganic & medicinal chemistry 20100501

• New drugs for neglected infectious diseases: Chagas' disease.

  British journal of pharmacology 20100501

• Computational identification of uncharacterized cruzain binding sites.

  PLoS neglected tropical diseases 20100501

• 'Manifesto' for advancing the control and elimination of neglected tropical diseases.

  PLoS neglected tropical diseases 20100501

• Chagas disease.

  Lancet (London, England) 20100417

• Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.

  Bioorganic & medicinal chemistry 20100415

• Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus.

  The American journal of tropical medicine and hygiene 20100401

• Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

  PLoS neglected tropical diseases 20100401

• Nanotechnological approaches against Chagas disease.

  Advanced drug delivery reviews 20100318

• Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

  Bioorganic & medicinal chemistry letters 20100315

• In vitro and in vivo experimental models for drug screening and development for Chagas disease.

  Memorias do Instituto Oswaldo Cruz 20100301

• Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole.

  Experimental parasitology 20100201

• Trypanosoma cruzi: Immunological predictors of benznidazole efficacy during experimental infection.

  Experimental parasitology 20100201

• Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.

  Acta tropica 20100201

• Prevalence, clinical staging and risk for blood-borne transmission of Chagas disease among Latin American migrants in Geneva, Switzerland.

  PLoS neglected tropical diseases 20100201

• [Emergence of Chagas' disease in Europe: description of the first cases observed in Latin American immigrants in mainland France].

  Medecine tropicale : revue du Corps de sante colonial 20100201

• Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.

  Acta tropica 20100101

• Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines.

  Bioorganic & medicinal chemistry 20100101

• Antibody drop in newborns congenitally infected by Trypanosoma cruzi treated with benznidazole.

  Tropical medicine & international health : TM & IH 20100101

• Chagas disease: progress and new perspectives.

  Current medicinal chemistry 20100101

• Inhibitory activity of marine sponge-derived natural products against parasitic protozoa.

  Marine drugs 20100101

• Trypanosomatid parasites causing neglected diseases.

  Current medicinal chemistry 20100101

• [Adverse reactions in Chagas disease patients treated with benznidazole, in the State of Ceará].

  Revista da Sociedade Brasileira de Medicina Tropical 20100101

• Development of and access to products for neglected diseases.

  PloS one 20100101

• Bromopyrrole alkaloids as lead compounds against protozoan parasites.

  Marine drugs 20100101

• Current and emerging therapeutic options for the treatment of chronic chagasic cardiomyopathy.

  Vascular health and risk management 20100101

• Current and developing therapeutic agents in the treatment of Chagas disease.

  Drug design, development and therapy 20100101

• Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment.

  BMC genomics 20100101

• Chagas disease: Present status of pathogenic mechanisms and chemotherapy.

  Biological research 20100101

• A comparative analysis of the Libyan national essential medicines list and the WHO model list of essential medicines.

  The Libyan journal of medicine 20100101

• New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies.

  Bioorganic & medicinal chemistry 20091215

• Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis.

  The Journal of antimicrobial chemotherapy 20091201

• Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.

  European journal of medicinal chemistry 20091201

• Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

• Recognizing and meeting the challenge of Chagas disease in the USA.

  Expert review of anti-infective therapy 20091201

• Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines.

  PLoS neglected tropical diseases 20091201

• [Chagas disease and immunodeficiency: HIV infection and transplantation].

  Bulletin de la Societe de pathologie exotique (1990) 20091201

• Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment.

  Memorias do Instituto Oswaldo Cruz 20091201

• Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.

  Journal of medicinal chemistry 20091112

• Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.

  European journal of medicinal chemistry 20091101

• 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.

  Bioorganic & medicinal chemistry 20091101

• Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras.

  Memorias do Instituto Oswaldo Cruz 20091101

• Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting myocarditis in benznidazole-treated mice.

  Memorias do Instituto Oswaldo Cruz 20091101

• Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.

  Bioorganic & medicinal chemistry 20091015

• Antiprotozoal and cytotoxic studies on some isocordoin derivatives.

  Planta medica 20091001

• Trypanosoma cruzi: Different methods of data analysis to evaluate the genetics-biology relationship.

  Experimental parasitology 20091001

• Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.

  Bioorganic & medicinal chemistry 20090915

• Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery.

  Diagnostic microbiology and infectious disease 20090901

• Aetiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection.

  Annals of tropical medicine and parasitology 20090901

• Profile of central and effector memory T cells in the progression of chronic human chagas disease.

  PLoS neglected tropical diseases 20090901

• In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.

  Biomedica : revista del Instituto Nacional de Salud 20090901

• [Chagas disease].

  La Revue de medecine interne 20090801

• Advancing drug innovation for neglected diseases-criteria for lead progression.

  PLoS neglected tropical diseases 20090801

• Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships.

  Bioorganic & medicinal chemistry 20090715

• Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles.

  European journal of medicinal chemistry 20090701

• Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi.

  Acta tropica 20090701

• Differential regional immune response in Chagas disease.

  PLoS neglected tropical diseases 20090701

• Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières.

  PLoS neglected tropical diseases 20090701

• New, improved treatments for Chagas disease: from the R&D pipeline to the patients.

  PLoS neglected tropical diseases 20090701

• Present situation and new strategies for Chagas disease chemotherapy: a proposal.

  Memorias do Instituto Oswaldo Cruz 20090701

• Ergosterol biosynthesis and drug development for Chagas disease.

  Memorias do Instituto Oswaldo Cruz 20090701

• The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease.

  Memorias do Instituto Oswaldo Cruz 20090701

• Novel cytostatic activity of the trypanocidal drug Benznidazole.

  International immunopharmacology 20090601

• Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

  Bioorganic & medicinal chemistry letters 20090601

• Chagas disease: the forgotten American neuroinfection.

  The Lancet. Neurology 20090601

• In vitro trypanocidal activity of phenolic derivatives from Peperomia obtusifolia.

  Planta medica 20090501

• Reduction of parasite levels in blood improves pregnancy outcome during experimental Trypanosoma cruzi infection.

  Parasitology 20090501

• Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.

  Experimental parasitology 20090501

• New perspectives of infections in cardiovascular disease.

  Current cardiology reviews 20090501

• Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

  European journal of medicinal chemistry 20090401

• 2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi.

  The Journal of parasitology 20090401

• Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.

  Bioorganic & medicinal chemistry 20090401

• A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease.

  Journal of cardiac failure 20090401

• Congenital transmission of Chagas disease in Latin American immigrants in Switzerland.

  Emerging infectious diseases 20090401

• Chagasic cardiomyopathy in immigrants from Latin America to Spain.

  Emerging infectious diseases 20090401

• Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients.

  PLoS neglected tropical diseases 20090401

• In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles.

  European journal of medicinal chemistry 20090301

• Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole.

  Parasitology research 20090301

• Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities.

  Expert review of anti-infective therapy 20090301

• Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence.

  PLoS neglected tropical diseases 20090301

• Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks.

  International journal of pharmaceutics 20090209

• Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones.

  Bioorganic & medicinal chemistry letters 20090201

• Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

  PLoS neglected tropical diseases 20090201

• Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening.

  PLoS neglected tropical diseases 20090201

• Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae).

  Parasitology research 20090101

• Trypanosoma cruzi: Genetic diversity influences the profile of immunoglobulins during experimental infection.

  Experimental parasitology 20090101

• Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.

  Antimicrobial agents and chemotherapy 20090101

• Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101

• Trypanosoma cruzi targets for new chemotherapeutic approaches.

  Expert opinion on therapeutic targets 20090101

• Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.

  Paediatric drugs 20090101

• Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi.

  PloS one 20090101

• Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole.

  Revista panamericana de salud publica = Pan American journal of public health 20090101

• Copper (II) complexes of [1,2,4]triazolo [1,5-a]pyrimidine derivatives as potential anti-parasitic agents.

  Drug metabolism letters 20090101

• GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi.

  Molecular systems biology 20090101

• Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi.

  BMC microbiology 20090101

• Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi.

  BMC systems biology 20090101

• [Fatal evolution of Chagas'disease/Aids co-infection: diagnostic difficulties between myocarditis reactivation and chronic chagasic myocardiopathy].

  Revista da Sociedade Brasileira de Medicina Tropical 20090101

• Experimental evaluation of insecticidal paints against Triatoma infestans (Hemiptera: Reduviidae), under natural climatic conditions.

  Parasites & vectors 20090101

• Accidental infection by Trypanosoma cruzi follow-up by the polymerase chain reaction: case report.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20090101

• Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission.

  Revista da Sociedade Brasileira de Medicina Tropical 20090101

• Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.

  Journal of parasitology research 20090101

• Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.

  Experimental parasitology 20081201

• Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.

  Experimental parasitology 20081201

• Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20081101

• Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture.

  The American journal of tropical medicine and hygiene 20081101

• Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds.

  Mini reviews in medicinal chemistry 20081101

• In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.

  European journal of medicinal chemistry 20081001

• Chagas disease and the US blood supply.

  Current opinion in infectious diseases 20081001

• Benznidazole and Chagas disease: can an old drug be the answer to an old problem?

  Expert opinion on investigational drugs 20081001

• High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection.

  PLoS neglected tropical diseases 20081001

• [Part VI. Antiparasitic treatment for Chagas disease].

  Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia 20081001

• Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies.

  European journal of medicinal chemistry 20080901

• Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole.

  Experimental parasitology 20080901

• Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.

  Bioorganic & medicinal chemistry 20080901

• Benzoic acid derivatives from Piper species and their antiparasitic activity.

  Journal of natural products 20080901

• Brazilian propolis: correlation between chemical composition and antimicrobial activity.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects.

  Memorias do Instituto Oswaldo Cruz 20080901

• Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

  European journal of medicinal chemistry 20080801

• Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi.

  European journal of medicinal chemistry 20080801

• Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.

  Journal of medicinal chemistry 20080724

• New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.

  Bioorganic & medicinal chemistry 20080715

• Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.

  Parasitology research 20080701

• Multiple NADPH-cytochrome P450 reductases from Trypanosoma cruzi suggested role on drug resistance.

  Molecular and biochemical parasitology 20080701

• Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole.

  Acta tropica 20080701

• Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).

  American heart journal 20080701

• Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes.

  The Journal of antimicrobial chemotherapy 20080601

• Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole.

  Journal of proteome research 20080601

• 4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity.

  European journal of medicinal chemistry 20080501

• Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones.

  Bioorganic & medicinal chemistry 20080501

• Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.

  Nature medicine 20080501

• Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.

  Bioorganic & medicinal chemistry letters 20080401

• Chagas disease, France.

  Emerging infectious diseases 20080401

• Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole.

  Homeopathy : the journal of the Faculty of Homeopathy 20080401

• Acute chagasic myocardiopathy after orthotopic liver transplantation with donor and recipient serologically negative for Trypanosoma cruzi: a case report.

  Transplantation proceedings 20080401

• Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings.

  Journal of medicinal chemistry 20080327

• Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole.

  Experimental parasitology 20080301

• Natural chromenes and chromene derivatives as potential anti-trypanosomal agents.

  Biological & pharmaceutical bulletin 20080301

• Voltammetric Behavior of o-Nitrophenol and Damage to DNA.

  International journal of molecular sciences 20080301

• Benznidazole.

  Acta crystallographica. Section E, Structure reports online 20080301

• Severe invalidating pain syndrome associated with benznidazole therapy for Chagas' disease.

  Clinical rheumatology 20080201

• Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern.

  Microbes and infection 20080201

• Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

  Bioorganic & medicinal chemistry 20080115

• Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids.

  European journal of medicinal chemistry 20080101

• Trypanosoma cruzi: characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations.

  Experimental parasitology 20080101

• Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.

  Bioorganic & medicinal chemistry letters 20080101

• Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.

  Advances in experimental medicine and biology 20080101

• Trypanosomiasis vector control in Africa and Latin America.

  Parasites & vectors 20080101

• Trypanosoma cruzi alkaline 2-DE: Optimization and application to comparative proteome analysis of flagellate life stages.

  Proteome science 20080101

• In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.

  Natural product research 20080101

• Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes.

  BMC cell biology 20080101

• Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides.

  Bioorganic & medicinal chemistry 20071215

• Targeted screening strategies to detect Trypanosoma cruzi infection in children.

  PLoS neglected tropical diseases 20071201

• Combining residual insecticide spraying campaigns with targeted detection and specific chemotherapy for Trypanosoma cruzi infection in children.

  PLoS neglected tropical diseases 20071201

• The challenges of Chagas Disease-- grim outlook or glimmer of hope.

  PLoS medicine 20071201

• In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

  Journal of medicinal chemistry 20071129

• Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

  Journal of medicinal chemistry 20071115

• Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

  Bioorganic & medicinal chemistry 20071101

• An overview of Chagas disease treatment.

  Memorias do Instituto Oswaldo Cruz 20071030

• Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice.

  Parasitology research 20071001

• Early nifurtimox-induced biochemical and ultrastructural alterations in rat heart.

  Human & experimental toxicology 20071001

• Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.

  ChemMedChem 20070901

• Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives.

  Bioorganic & medicinal chemistry letters 20070801

• Chagas disease: clinical overview and implications for nursing.

  Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20070801

• DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi.

  Experimental parasitology 20070701

• Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.

  International journal of antimicrobial agents 20070601

• Usefulness of PCR strategies for early diagnosis of Chagas' disease reactivation and treatment follow-up in heart transplantation.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070601

• Chagas' disease reactivation with skin symptoms in a patient with kidney transplant.

  International journal of dermatology 20070601

• Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070401

• The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.

  Antimicrobial agents and chemotherapy 20070401

• Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.

  Bioorganic & medicinal chemistry 20070401

• In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.

  Journal of enzyme inhibition and medicinal chemistry 20070401

• In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi.

  Parasitology research 20070301

• Liver transplantation from deceased donors serologically positive for Chagas disease.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070301

• 1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.

  Bioorganic & medicinal chemistry 20070301

• [Chest pain and peripheral eosinophilia].

  Revista clinica espanola 20070201

• Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.

  Journal of ethnopharmacology 20070119

• Synthesis and trypanocidal activity of ent-kaurane glycosides.

  Bioorganic & medicinal chemistry 20070101

• Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series.

  Bioorganic & medicinal chemistry 20070101

• Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS.

  Annals of tropical medicine and parasitology 20070101

• Trypanocide treatment among adults with chronic Chagas disease living in Santa Fe city (Argentina), over a mean follow-up of 21 years: parasitological, serological and clinical evolution.

  Revista da Sociedade Brasileira de Medicina Tropical 20070101

• Novel potential drug against T. cruzi and its interaction with surfactant micelles.

  Pharmaceutical development and technology 20070101

• Chagas disease: an impediment in achieving the Millennium Development Goals in Latin America.

  BMC international health and human rights 20070101

• Mexican Trypanosoma cruzi isolates: in vitro susceptibility of epimastigotes to anti-trypanosoma cruzi drugs and metacyclic forms to complement-mediated lysis.

  Vector borne and zoonotic diseases (Larchmont, N.Y.) 20070101

• Mitochondrial bioenergetics after nine-day treatment regimen with benzonidazole in rats.

  International journal of toxicology 20070101

• An insight on targets and patented drugs for chemotherapy of Chagas disease.

  Recent patents on anti-infective drug discovery 20070101

• New prescriptions for neglected diseases.

  Open medicine : a peer-reviewed, independent, open-access journal 20070101

• Electrocardiographic findings in acutely and chronically T. cruzi-infected mice treated by a phenyl-substituted analogue of furamidine DB569.

  Drug target insights 20070101

• Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.

  Drug target insights 20070101

• Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.

  Experimental parasitology 20061101

• Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol.

  Bioorganic & medicinal chemistry 20061101

• Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile.

  Scandinavian journal of immunology 20061101

• In vitro antiprotozoal activity of the lipophilic extracts of different parts of Turkish Pistacia vera L.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20061101

• Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole.

  Acta tropica 20061101

• Activity of neolignans isolated from Piper regnellii (MIQ.) C. DC. var. pallescens (C. DC.) YUNCK against Trypanosoma cruzi.

  Biological & pharmaceutical bulletin 20061001

• Detection of parasitemia profiles by blood culture after treatment of human chronic Trypanosoma cruzi infection.

  Parasitology research 20060901

• Noncommunicable diseases and injuries in Latin America and the Caribbean: time for action.

  PLoS medicine 20060901

• Polymerase chain reaction detection and serologic follow-up after treatment with benznidazole in Bolivian children infected with a natural mixture of Trypanosoma cruzi I and II.

  The American journal of tropical medicine and hygiene 20060901

• Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium.

  Bioorganic & medicinal chemistry 20060815

• Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis).

  Human & experimental toxicology 20060801

• Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

  Bioorganic & medicinal chemistry letters 20060715

• Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes.

  Parasitology research 20060701

• 2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.

  Journal of medicinal chemistry 20060601

• The thymus is a common target organ in infectious diseases.

  PLoS pathogens 20060601

• Summaries for patients. Long-term outcomes of treating nonacute Chagas disease with benznidazole.

  Annals of internal medicine 20060516

• Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial.

  Annals of internal medicine 20060516

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Chagas disease: hidden affliction and visible neglect.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060411

• Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.

  Molecular and biochemical parasitology 20060401

• Treatment of experimental chronic chagas disease with trifluralin.

  Basic & clinical pharmacology & toxicology 20060401

• Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole.

  International journal of pharmaceutics 20060113

• Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.

  European journal of medicinal chemistry 20060101

• Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis.

  Pharmacology 20060101

• [Recommendations for diagnosis, treatment and follow-up of the Trypanosoma cruzi: human immunodeficiency virus co-infection].

  Revista da Sociedade Brasileira de Medicina Tropical 20060101

• Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS.

  The American journal of tropical medicine and hygiene 20051201

• Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

  Journal of medicinal chemistry 20051117

• The need of a neonatal preparation for Chagas disease.

  PLoS medicine 20051101

• Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).

  The Cochrane database of systematic reviews 20051019

• Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area.

  Experimental parasitology 20051001

• Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20050901

• [Mechanisms responsible for myocardial damage progression in chronic Chagas' disease].

  Revista espanola de cardiologia 20050901

• [Clinical predictors of chronic chagasic myocarditis progression].

  Revista espanola de cardiologia 20050901

• Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.

  Journal of medicinal chemistry 20050825

• Chagas disease in bone marrow transplantation: an approach to preemptive therapy.

  Bone marrow transplantation 20050701

• Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.

  Journal of natural products 20050501

• ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the 'new'plant species Ancistrocladus benomensis.

  Journal of natural products 20050501

• Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans.

  Memorias do Instituto Oswaldo Cruz 20050501

• Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.

  Journal of enzyme inhibition and medicinal chemistry 20050401

• Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?

  Memorias do Instituto Oswaldo Cruz 20050401

• A new pharmacological screening assay with Trypanosoma cruzi epimastigotes expressing beta-galactosidase.

  Parasitology research 20050301

• Amino acid metabolic routes in Trypanosoma cruzi: possible therapeutic targets against Chagas' disease.

  Current drug targets. Infectious disorders 20050301

• The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes.

  The Journal of parasitology 20050201

• Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II).

  Revista da Sociedade Brasileira de Medicina Tropical 20050101

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20050101

• [Implementation and evaluation of a locally sustainable system of prenatal diagnosis to detect cases of congenital Chagas disease in endemic areas of Paraguay].

  Revista da Sociedade Brasileira de Medicina Tropical 20050101

• Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.

  Life sciences 20041224

• Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the 'new' plant species ancistrocladusbenomensis.

  Journal of natural products 20041201

• Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes.

  Memorias do Instituto Oswaldo Cruz 20041201

• Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up.

  The American journal of tropical medicine and hygiene 20041101

• Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough.

  International journal of pharmaceutics 20040708

• Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes.

  The Journal of antimicrobial chemotherapy 20040601

• Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives.

  Farmaco (Societa chimica italiana : 1989) 20040601

• Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.

  Journal of natural products 20040501

• Chagas seropositive donors in kidney transplantation.

  Transplantation proceedings 20040501

• In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi.

  Memorias do Instituto Oswaldo Cruz 20040301

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20040101

• Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.

  Biological research 20040101

• [Longitudinal study and specific chemotherapy in children with chronic Chagas' disease, residing in a low endemicity area of Argentina].

  Revista da Sociedade Brasileira de Medicina Tropical 20040101

• Lack of correlation between in vitro susceptibility to Benznidazole and phylogenetic diversity of Trypanosoma cruzi, the agent of Chagas disease.

  Experimental parasitology 20040101

• Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus.

  Toxicology 20030930

• Synthesis and evaluation of a series of 1,4-diarylbutadienes for anticoccidial activity.

  Bioorganic & medicinal chemistry 20030901

• Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment.

  Clinical and diagnostic laboratory immunology 20030901

• Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.

  Journal of natural products 20030901

• Liposomal benznidazole: a high-performance liquid chromatographic determination for biodistribution studies.

  Journal of chromatographic science 20030901

• Trypanosoma cruzi: genetic group with peculiar biochemical and biological behavior.

  Memorias do Instituto Oswaldo Cruz 20030701

• The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.

  Bioorganic & medicinal chemistry letters 20030616

• Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives.

  Bioorganic & medicinal chemistry 20030612

• Nitroheterocyclic drugs with broad spectrum activity.

  Parasitology research 20030601

• Inhibition of Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II by N-isopropyl oxamate and its effect on intact epimastigotes.

  Journal of enzyme inhibition and medicinal chemistry 20030601

• Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents.

  Chembiochem : a European journal of chemical biology 20030103

• [Anti-F2/3 antibodies as cure marker in children with congenital Trypanosoma cruzi infection].

  Medicina 20030101

• Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain.

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• [Trypanosoma cruzi high parasitemia in patient with systemic lupus erythematosus].

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines.

  European journal of medicinal chemistry 20030101

• Development and in vitro characterisation of a benznidazole liposomal formulation.

  International journal of pharmaceutics 20021205

• Relationship between long-term resistance to Trypanosoma cruzi and latent infection, examined by antibody production and polymerase chain reaction in mice.

  The Journal of parasitology 20021201

• Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain.

  Memorias do Instituto Oswaldo Cruz 20021201

• Chemotherapy of Chagas' disease: status and new developments.

  Current topics in medicinal chemistry 20021101

• Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.

  Antimicrobial agents and chemotherapy 20021101

• The dog as model for chemotherapy of the Chagas' disease.

  Acta tropica 20021001

• Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure.

  The Journal of infectious diseases 20020915

• Cerebral trypanosomiasis and AIDS.

  Arquivos de neuro-psiquiatria 20020901

• Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.

  Journal of natural products 20020801

• Voltammetric behavior of benznidazole at a DNA-electrochemical biosensor.

  Journal of pharmaceutical and biomedical analysis 20020701

• Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution.

  Current drug targets. Cardiovascular & haematological disorders 20020601

• The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.

  Annals of tropical medicine and parasitology 20020401

• In vitro and in vivo assays of 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives against Trypanosoma cruzi.

  Memorias do Instituto Oswaldo Cruz 20020301

• African trypanosomiasis in travelers returning to the United Kingdom.

  Emerging infectious diseases 20020101

• Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection.

  The Cochrane database of systematic reviews 20020101

• Long term evaluation of etiological treatment of chagas disease with benznidazole.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20020101

• A critical review on Chagas disease chemotherapy.

  Memorias do Instituto Oswaldo Cruz 20020101

• TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.

  International journal of experimental pathology 20011201

• Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.

  Phytotherapy research : PTR 20011101

• Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.

  Bioorganic & medicinal chemistry letters 20011022

• Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.

  Molecular and biochemical parasitology 20011001

• Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.

  Memorias do Instituto Oswaldo Cruz 20011001

• Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kappaB activation.

  Journal of immunology (Baltimore, Md. : 1950) 20010915

• Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds.

  Bioorganic & medicinal chemistry letters 20010723

• Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.

  Parasitology research 20010701

• Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

  Journal of medicinal chemistry 20010621

• Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

  Journal of medicinal chemistry 20010315

• A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20010122

• Biological characterization of Trypanosoma cruzi strains.

  Memorias do Instituto Oswaldo Cruz 20010101

• New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes.

  Folia parasitologica 20010101

• Time-dependent oxidative stress caused by benznidazole.

  Redox report : communications in free radical research 20010101

• Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi.

  Revista latinoamericana de microbiologia 20010101

• Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.

  Antimicrobial agents and chemotherapy 19920901

• Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.

  British journal of cancer 19820801

• Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships.

  International journal of radiation oncology, biology, physics 19820101

• Single-dose pharmacokinetics of the trypanosomicide benznidazole in man.

  Arzneimittel-Forschung 19790101