22994-85-0 | Benznidazole

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$122.00	$86.00
1g	98%	in stock	$283.00	$198.00
5g	98%	in stock	$1,109.00	$777.00
10g	98%	in stock	$2,159.00	$1,511.00

Description

• Catalog Number: AB21368
• Chemical Name: Benznidazole
• CAS Number: 22994-85-0
• Molecular Formula: C12H12N4O3
• Molecular Weight: 260.2487
• MDL Number: MFCD00243089
• SMILES: O=C(Cn1ccnc1[N+](=O)[O-])NCc1ccccc1
• NSC Number: 299972

Computed Properties

• Complexity: 325
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 0.9

Literature

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  Bioorganic & medicinal chemistry 20100501

• New drugs for neglected infectious diseases: Chagas' disease.

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  The American journal of tropical medicine and hygiene 20100401

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  Advanced drug delivery reviews 20100318

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  Memorias do Instituto Oswaldo Cruz 20100301

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  Experimental parasitology 20100201

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  Experimental parasitology 20100201

• Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.

  Acta tropica 20100201

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  Bioorganic & medicinal chemistry 20100101

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  Tropical medicine & international health : TM & IH 20100101

• Chagas disease: progress and new perspectives.

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  The Libyan journal of medicine 20100101

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  Bioorganic & medicinal chemistry 20091215

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  The Journal of antimicrobial chemotherapy 20091201

• Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.

  European journal of medicinal chemistry 20091201

• Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

• Recognizing and meeting the challenge of Chagas disease in the USA.

  Expert review of anti-infective therapy 20091201

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  Memorias do Instituto Oswaldo Cruz 20091201

• Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.

  Journal of medicinal chemistry 20091112

• Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.

  European journal of medicinal chemistry 20091101

• 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.

  Bioorganic & medicinal chemistry 20091101

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  Memorias do Instituto Oswaldo Cruz 20091101

• Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting myocarditis in benznidazole-treated mice.

  Memorias do Instituto Oswaldo Cruz 20091101

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  Bioorganic & medicinal chemistry 20091015

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  Planta medica 20091001

• Trypanosoma cruzi: Different methods of data analysis to evaluate the genetics-biology relationship.

  Experimental parasitology 20091001

• Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents.

  Bioorganic & medicinal chemistry 20090915

• Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery.

  Diagnostic microbiology and infectious disease 20090901

• Aetiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection.

  Annals of tropical medicine and parasitology 20090901

• Profile of central and effector memory T cells in the progression of chronic human chagas disease.

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• In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.

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  Bioorganic & medicinal chemistry 20090715

• Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles.

  European journal of medicinal chemistry 20090701

• Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi.

  Acta tropica 20090701

• Differential regional immune response in Chagas disease.

  PLoS neglected tropical diseases 20090701

• Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières.

  PLoS neglected tropical diseases 20090701

• New, improved treatments for Chagas disease: from the R&D pipeline to the patients.

  PLoS neglected tropical diseases 20090701

• Present situation and new strategies for Chagas disease chemotherapy: a proposal.

  Memorias do Instituto Oswaldo Cruz 20090701

• Ergosterol biosynthesis and drug development for Chagas disease.

  Memorias do Instituto Oswaldo Cruz 20090701

• The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease.

  Memorias do Instituto Oswaldo Cruz 20090701

• Novel cytostatic activity of the trypanocidal drug Benznidazole.

  International immunopharmacology 20090601

• Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

  Bioorganic & medicinal chemistry letters 20090601

• Chagas disease: the forgotten American neuroinfection.

  The Lancet. Neurology 20090601

• In vitro trypanocidal activity of phenolic derivatives from Peperomia obtusifolia.

  Planta medica 20090501

• Reduction of parasite levels in blood improves pregnancy outcome during experimental Trypanosoma cruzi infection.

  Parasitology 20090501

• Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.

  Experimental parasitology 20090501

• New perspectives of infections in cardiovascular disease.

  Current cardiology reviews 20090501

• Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

  European journal of medicinal chemistry 20090401

• 2,3-diphenyl-1,4-naphthoquinone: a potential chemotherapeutic agent against Trypanosoma cruzi.

  The Journal of parasitology 20090401

• Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.

  Bioorganic & medicinal chemistry 20090401

• A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease.

  Journal of cardiac failure 20090401

• Congenital transmission of Chagas disease in Latin American immigrants in Switzerland.

  Emerging infectious diseases 20090401

• Chagasic cardiomyopathy in immigrants from Latin America to Spain.

  Emerging infectious diseases 20090401

• Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients.

  PLoS neglected tropical diseases 20090401

• In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles.

  European journal of medicinal chemistry 20090301

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  Expert review of anti-infective therapy 20090301

• Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence.

  PLoS neglected tropical diseases 20090301

• Development of novel formulations for Chagas' disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks.

  International journal of pharmaceutics 20090209

• Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones.

  Bioorganic & medicinal chemistry letters 20090201

• Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

  PLoS neglected tropical diseases 20090201

• Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening.

  PLoS neglected tropical diseases 20090201

• Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae).

  Parasitology research 20090101

• Trypanosoma cruzi: Genetic diversity influences the profile of immunoglobulins during experimental infection.

  Experimental parasitology 20090101

• Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.

  Antimicrobial agents and chemotherapy 20090101

• Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101

• Trypanosoma cruzi targets for new chemotherapeutic approaches.

  Expert opinion on therapeutic targets 20090101

• Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.

  Paediatric drugs 20090101

• Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi.

  PloS one 20090101

• Urban outbreak of acute Chagas disease in Amazon region of Brazil: four-year follow-up after treatment with benznidazole.

  Revista panamericana de salud publica = Pan American journal of public health 20090101

• Copper (II) complexes of [1,2,4]triazolo [1,5-a]pyrimidine derivatives as potential anti-parasitic agents.

  Drug metabolism letters 20090101

• GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi.

  Molecular systems biology 20090101

• Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi.

  BMC microbiology 20090101

• Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi.

  BMC systems biology 20090101

• [Fatal evolution of Chagas'disease/Aids co-infection: diagnostic difficulties between myocarditis reactivation and chronic chagasic myocardiopathy].

  Revista da Sociedade Brasileira de Medicina Tropical 20090101

• Experimental evaluation of insecticidal paints against Triatoma infestans (Hemiptera: Reduviidae), under natural climatic conditions.

  Parasites & vectors 20090101

• Accidental infection by Trypanosoma cruzi follow-up by the polymerase chain reaction: case report.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20090101

• Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission.

  Revista da Sociedade Brasileira de Medicina Tropical 20090101

• Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.

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• Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.

  Experimental parasitology 20081201

• Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.

  Experimental parasitology 20081201

• Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20081101

• Beneficial effects of benznidazole during an infectious-based situation of systemic inflammatory response: cecal ligation and puncture.

  The American journal of tropical medicine and hygiene 20081101

• Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds.

  Mini reviews in medicinal chemistry 20081101

• In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.

  European journal of medicinal chemistry 20081001

• Chagas disease and the US blood supply.

  Current opinion in infectious diseases 20081001

• Benznidazole and Chagas disease: can an old drug be the answer to an old problem?

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  Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia 20081001

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  European journal of medicinal chemistry 20080901

• Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole.

  Experimental parasitology 20080901

• Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.

  Bioorganic & medicinal chemistry 20080901

• Benzoic acid derivatives from Piper species and their antiparasitic activity.

  Journal of natural products 20080901

• Brazilian propolis: correlation between chemical composition and antimicrobial activity.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects.

  Memorias do Instituto Oswaldo Cruz 20080901

• Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

  European journal of medicinal chemistry 20080801

• Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi.

  European journal of medicinal chemistry 20080801

• Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.

  Journal of medicinal chemistry 20080724

• New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.

  Bioorganic & medicinal chemistry 20080715

• Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.

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  Molecular and biochemical parasitology 20080701

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  Acta tropica 20080701

• Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).

  American heart journal 20080701

• Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes.

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• Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole.

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• 4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity.

  European journal of medicinal chemistry 20080501

• Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones.

  Bioorganic & medicinal chemistry 20080501

• Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.

  Nature medicine 20080501

• Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.

  Bioorganic & medicinal chemistry letters 20080401

• Chagas disease, France.

  Emerging infectious diseases 20080401

• Changes of RAPD profile of Trypanosoma cruzi II with Canova and Benznidazole.

  Homeopathy : the journal of the Faculty of Homeopathy 20080401

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  Transplantation proceedings 20080401

• Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings.

  Journal of medicinal chemistry 20080327

• Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole.

  Experimental parasitology 20080301

• Natural chromenes and chromene derivatives as potential anti-trypanosomal agents.

  Biological & pharmaceutical bulletin 20080301

• Voltammetric Behavior of o-Nitrophenol and Damage to DNA.

  International journal of molecular sciences 20080301

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• Severe invalidating pain syndrome associated with benznidazole therapy for Chagas' disease.

  Clinical rheumatology 20080201

• Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern.

  Microbes and infection 20080201

• Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

  Bioorganic & medicinal chemistry 20080115

• Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids.

  European journal of medicinal chemistry 20080101

• Trypanosoma cruzi: characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations.

  Experimental parasitology 20080101

• Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.

  Bioorganic & medicinal chemistry letters 20080101

• Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.

  Advances in experimental medicine and biology 20080101

• Trypanosomiasis vector control in Africa and Latin America.

  Parasites & vectors 20080101

• Trypanosoma cruzi alkaline 2-DE: Optimization and application to comparative proteome analysis of flagellate life stages.

  Proteome science 20080101

• In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi.

  Natural product research 20080101

• Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes.

  BMC cell biology 20080101

• Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides.

  Bioorganic & medicinal chemistry 20071215

• Targeted screening strategies to detect Trypanosoma cruzi infection in children.

  PLoS neglected tropical diseases 20071201

• Combining residual insecticide spraying campaigns with targeted detection and specific chemotherapy for Trypanosoma cruzi infection in children.

  PLoS neglected tropical diseases 20071201

• The challenges of Chagas Disease-- grim outlook or glimmer of hope.

  PLoS medicine 20071201

• In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

  Journal of medicinal chemistry 20071129

• Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

  Journal of medicinal chemistry 20071115

• Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

  Bioorganic & medicinal chemistry 20071101

• An overview of Chagas disease treatment.

  Memorias do Instituto Oswaldo Cruz 20071030

• Allopurinol is effective to modify the evolution of Trypanosoma cruzi infection in mice.

  Parasitology research 20071001

• Early nifurtimox-induced biochemical and ultrastructural alterations in rat heart.

  Human & experimental toxicology 20071001

• Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.

  ChemMedChem 20070901

• Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives.

  Bioorganic & medicinal chemistry letters 20070801

• Chagas disease: clinical overview and implications for nursing.

  Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20070801

• DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi.

  Experimental parasitology 20070701

• Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.

  International journal of antimicrobial agents 20070601

• Usefulness of PCR strategies for early diagnosis of Chagas' disease reactivation and treatment follow-up in heart transplantation.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070601

• Chagas' disease reactivation with skin symptoms in a patient with kidney transplant.

  International journal of dermatology 20070601

• Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070401

• The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.

  Antimicrobial agents and chemotherapy 20070401

• Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.

  Bioorganic & medicinal chemistry 20070401

• In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.

  Journal of enzyme inhibition and medicinal chemistry 20070401

• In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi.

  Parasitology research 20070301

• Liver transplantation from deceased donors serologically positive for Chagas disease.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070301

• 1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.

  Bioorganic & medicinal chemistry 20070301

• [Chest pain and peripheral eosinophilia].

  Revista clinica espanola 20070201

• Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.

  Journal of ethnopharmacology 20070119

• Synthesis and trypanocidal activity of ent-kaurane glycosides.

  Bioorganic & medicinal chemistry 20070101

• Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series.

  Bioorganic & medicinal chemistry 20070101

• Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS.

  Annals of tropical medicine and parasitology 20070101

• Trypanocide treatment among adults with chronic Chagas disease living in Santa Fe city (Argentina), over a mean follow-up of 21 years: parasitological, serological and clinical evolution.

  Revista da Sociedade Brasileira de Medicina Tropical 20070101

• Novel potential drug against T. cruzi and its interaction with surfactant micelles.

  Pharmaceutical development and technology 20070101

• Chagas disease: an impediment in achieving the Millennium Development Goals in Latin America.

  BMC international health and human rights 20070101

• Mexican Trypanosoma cruzi isolates: in vitro susceptibility of epimastigotes to anti-trypanosoma cruzi drugs and metacyclic forms to complement-mediated lysis.

  Vector borne and zoonotic diseases (Larchmont, N.Y.) 20070101

• Mitochondrial bioenergetics after nine-day treatment regimen with benzonidazole in rats.

  International journal of toxicology 20070101

• An insight on targets and patented drugs for chemotherapy of Chagas disease.

  Recent patents on anti-infective drug discovery 20070101

• New prescriptions for neglected diseases.

  Open medicine : a peer-reviewed, independent, open-access journal 20070101

• Electrocardiographic findings in acutely and chronically T. cruzi-infected mice treated by a phenyl-substituted analogue of furamidine DB569.

  Drug target insights 20070101

• Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.

  Drug target insights 20070101

• Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.

  Experimental parasitology 20061101

• Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol.

  Bioorganic & medicinal chemistry 20061101

• Benznidazole treatment during early-indeterminate Chagas' disease shifted the cytokine expression by innate and adaptive immunity cells toward a type 1-modulated immune profile.

  Scandinavian journal of immunology 20061101

• In vitro antiprotozoal activity of the lipophilic extracts of different parts of Turkish Pistacia vera L.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20061101

• Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole.

  Acta tropica 20061101

• Activity of neolignans isolated from Piper regnellii (MIQ.) C. DC. var. pallescens (C. DC.) YUNCK against Trypanosoma cruzi.

  Biological & pharmaceutical bulletin 20061001

• Detection of parasitemia profiles by blood culture after treatment of human chronic Trypanosoma cruzi infection.

  Parasitology research 20060901

• Noncommunicable diseases and injuries in Latin America and the Caribbean: time for action.

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• Polymerase chain reaction detection and serologic follow-up after treatment with benznidazole in Bolivian children infected with a natural mixture of Trypanosoma cruzi I and II.

  The American journal of tropical medicine and hygiene 20060901

• Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium.

  Bioorganic & medicinal chemistry 20060815

• Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis).

  Human & experimental toxicology 20060801

• Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.

  Bioorganic & medicinal chemistry letters 20060715

• Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes.

  Parasitology research 20060701

• 2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.

  Journal of medicinal chemistry 20060601

• The thymus is a common target organ in infectious diseases.

  PLoS pathogens 20060601

• Summaries for patients. Long-term outcomes of treating nonacute Chagas disease with benznidazole.

  Annals of internal medicine 20060516

• Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial.

  Annals of internal medicine 20060516

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Chagas disease: hidden affliction and visible neglect.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060411

• Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.

  Molecular and biochemical parasitology 20060401

• Treatment of experimental chronic chagas disease with trifluralin.

  Basic & clinical pharmacology & toxicology 20060401

• Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole.

  International journal of pharmaceutics 20060113

• Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N'-[(4-Y-phenyl)methylene]-1H-pyrazole-4-carbohydrazides.

  European journal of medicinal chemistry 20060101

• Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis.

  Pharmacology 20060101

• [Recommendations for diagnosis, treatment and follow-up of the Trypanosoma cruzi: human immunodeficiency virus co-infection].

  Revista da Sociedade Brasileira de Medicina Tropical 20060101

• Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS.

  The American journal of tropical medicine and hygiene 20051201

• Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

  Journal of medicinal chemistry 20051117

• The need of a neonatal preparation for Chagas disease.

  PLoS medicine 20051101

• Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).

  The Cochrane database of systematic reviews 20051019

• Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area.

  Experimental parasitology 20051001

• Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20050901

• [Mechanisms responsible for myocardial damage progression in chronic Chagas' disease].

  Revista espanola de cardiologia 20050901

• [Clinical predictors of chronic chagasic myocarditis progression].

  Revista espanola de cardiologia 20050901

• Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.

  Journal of medicinal chemistry 20050825

• Chagas disease in bone marrow transplantation: an approach to preemptive therapy.

  Bone marrow transplantation 20050701

• Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.

  Journal of natural products 20050501

• ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the 'new'plant species Ancistrocladus benomensis.

  Journal of natural products 20050501

• Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans.

  Memorias do Instituto Oswaldo Cruz 20050501

• Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.

  Journal of enzyme inhibition and medicinal chemistry 20050401

• Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?

  Memorias do Instituto Oswaldo Cruz 20050401

• A new pharmacological screening assay with Trypanosoma cruzi epimastigotes expressing beta-galactosidase.

  Parasitology research 20050301

• Amino acid metabolic routes in Trypanosoma cruzi: possible therapeutic targets against Chagas' disease.

  Current drug targets. Infectious disorders 20050301

• The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes.

  The Journal of parasitology 20050201

• Response to chemotherapy with benznidazole of clones isolated from the 21SF strain of Trypanosoma cruzi (biodeme Type II, Trypanosoma cruzi II).

  Revista da Sociedade Brasileira de Medicina Tropical 20050101

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20050101

• [Implementation and evaluation of a locally sustainable system of prenatal diagnosis to detect cases of congenital Chagas disease in endemic areas of Paraguay].

  Revista da Sociedade Brasileira de Medicina Tropical 20050101

• Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.

  Life sciences 20041224

• Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the 'new' plant species ancistrocladusbenomensis.

  Journal of natural products 20041201

• Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes.

  Memorias do Instituto Oswaldo Cruz 20041201

• Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up.

  The American journal of tropical medicine and hygiene 20041101

• Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough.

  International journal of pharmaceutics 20040708

• Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes.

  The Journal of antimicrobial chemotherapy 20040601

• Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives.

  Farmaco (Societa chimica italiana : 1989) 20040601

• Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.

  Journal of natural products 20040501

• Chagas seropositive donors in kidney transplantation.

  Transplantation proceedings 20040501

• In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi.

  Memorias do Instituto Oswaldo Cruz 20040301

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20040101

• Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.

  Biological research 20040101

• [Longitudinal study and specific chemotherapy in children with chronic Chagas' disease, residing in a low endemicity area of Argentina].

  Revista da Sociedade Brasileira de Medicina Tropical 20040101

• Lack of correlation between in vitro susceptibility to Benznidazole and phylogenetic diversity of Trypanosoma cruzi, the agent of Chagas disease.

  Experimental parasitology 20040101

• Benznidazole-induced ultrastructural and biochemical alterations in rat esophagus.

  Toxicology 20030930

• Synthesis and evaluation of a series of 1,4-diarylbutadienes for anticoccidial activity.

  Bioorganic & medicinal chemistry 20030901

• Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment.

  Clinical and diagnostic laboratory immunology 20030901

• Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.

  Journal of natural products 20030901

• Liposomal benznidazole: a high-performance liquid chromatographic determination for biodistribution studies.

  Journal of chromatographic science 20030901

• Trypanosoma cruzi: genetic group with peculiar biochemical and biological behavior.

  Memorias do Instituto Oswaldo Cruz 20030701

• The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.

  Bioorganic & medicinal chemistry letters 20030616

• Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives.

  Bioorganic & medicinal chemistry 20030612

• Nitroheterocyclic drugs with broad spectrum activity.

  Parasitology research 20030601

• Inhibition of Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II by N-isopropyl oxamate and its effect on intact epimastigotes.

  Journal of enzyme inhibition and medicinal chemistry 20030601

• Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents.

  Chembiochem : a European journal of chemical biology 20030103

• [Anti-F2/3 antibodies as cure marker in children with congenital Trypanosoma cruzi infection].

  Medicina 20030101

• Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain.

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• [Trypanosoma cruzi high parasitemia in patient with systemic lupus erythematosus].

  Revista da Sociedade Brasileira de Medicina Tropical 20030101

• Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines.

  European journal of medicinal chemistry 20030101

• Development and in vitro characterisation of a benznidazole liposomal formulation.

  International journal of pharmaceutics 20021205

• Relationship between long-term resistance to Trypanosoma cruzi and latent infection, examined by antibody production and polymerase chain reaction in mice.

  The Journal of parasitology 20021201

• Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain.

  Memorias do Instituto Oswaldo Cruz 20021201

• Chemotherapy of Chagas' disease: status and new developments.

  Current topics in medicinal chemistry 20021101

• Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi.

  Antimicrobial agents and chemotherapy 20021101

• The dog as model for chemotherapy of the Chagas' disease.

  Acta tropica 20021001

• Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure.

  The Journal of infectious diseases 20020915

• Cerebral trypanosomiasis and AIDS.

  Arquivos de neuro-psiquiatria 20020901

• Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.

  Journal of natural products 20020801

• Voltammetric behavior of benznidazole at a DNA-electrochemical biosensor.

  Journal of pharmaceutical and biomedical analysis 20020701

• Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution.

  Current drug targets. Cardiovascular & haematological disorders 20020601

• The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.

  Annals of tropical medicine and parasitology 20020401

• In vitro and in vivo assays of 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives against Trypanosoma cruzi.

  Memorias do Instituto Oswaldo Cruz 20020301

• African trypanosomiasis in travelers returning to the United Kingdom.

  Emerging infectious diseases 20020101

• Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection.

  The Cochrane database of systematic reviews 20020101

• Long term evaluation of etiological treatment of chagas disease with benznidazole.

  Revista do Instituto de Medicina Tropical de Sao Paulo 20020101

• A critical review on Chagas disease chemotherapy.

  Memorias do Instituto Oswaldo Cruz 20020101

• TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.

  International journal of experimental pathology 20011201

• Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.

  Phytotherapy research : PTR 20011101

• Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.

  Bioorganic & medicinal chemistry letters 20011022

• Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.

  Molecular and biochemical parasitology 20011001

• Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.

  Memorias do Instituto Oswaldo Cruz 20011001

• Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kappaB activation.

  Journal of immunology (Baltimore, Md. : 1950) 20010915

• Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds.

  Bioorganic & medicinal chemistry letters 20010723

• Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.

  Parasitology research 20010701

• Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

  Journal of medicinal chemistry 20010621

• Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

  Journal of medicinal chemistry 20010315

• A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20010122

• Biological characterization of Trypanosoma cruzi strains.

  Memorias do Instituto Oswaldo Cruz 20010101

• New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes.

  Folia parasitologica 20010101

• Time-dependent oxidative stress caused by benznidazole.

  Redox report : communications in free radical research 20010101

• Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi.

  Revista latinoamericana de microbiologia 20010101

• Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.

  Antimicrobial agents and chemotherapy 19920901

• Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.

  British journal of cancer 19820801

• Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships.

  International journal of radiation oncology, biology, physics 19820101

• Single-dose pharmacokinetics of the trypanosomicide benznidazole in man.

  Arzneimittel-Forschung 19790101