23288-49-5 | 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$15.00	$10.00
250mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$25.00	$17.00
5g	98%	in stock	$42.00	$30.00
25g	98%	in stock	$81.00	$57.00
100g	98%	in stock	$260.00	$182.00
500g	98%	in stock	$688.00	$482.00

Description

• Catalog Number: AB22651
• Chemical Name: 2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
• CAS Number: 23288-49-5
• Molecular Formula: C31H48O2S2
• Molecular Weight: 516.8416
• MDL Number: MFCD00079281
• SMILES: CC(Sc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)(Sc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)C

Computed Properties

• Complexity: 583
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• XLogP3: 11.3

Literature

• Why are most phospholipidosis inducers also hERG blockers?

  Archives of toxicology 20171201

• Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats.

  Chemico-biological interactions 20170925

• Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury.

  Oncotarget 20170808

• Methylmercury-induced developmental toxicity is associated with oxidative stress and cofilin phosphorylation. Cellular and human studies.

  Neurotoxicology 20170301

• Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons.

  Chemico-biological interactions 20150905

• Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

  Pharmacological research 20131001

• Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?

  Toxicological sciences : an official journal of the Society of Toxicology 20121201

• Improved intestinal absorption of a poorly water-soluble oral drug using mannitol microparticles containing a nanosolid drug dispersion.

  Journal of pharmaceutical sciences 20121101

• Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids.

  Pharmaceutical research 20121001

• A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol.

  Journal of geriatric cardiology : JGC 20120901

• Nanoparticulation of probucol, a poorly water-soluble drug, using a novel wet-milling process to improve in vitro dissolution and in vivo oral absorption.

  Drug development and industrial pharmacy 20120801

• Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation.

  Phytochemistry 20120801

• Development of a novel model of hypertriglyceridemic acute pancreatitis in hamsters: protective effects of probucol.

  Pancreas 20120801

• Nano-pulverization of poorly water soluble compounds with low melting points by a rotation/revolution pulverizer.

  Die Pharmazie 20120801

• Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses.

  Bulletin of experimental biology and medicine 20120801

• Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion.

  Chinese medical journal 20120701

• [Effects of three different treatments on atherosclerosis and adipose in rats].

  Zhonghua yi xue za zhi 20120619

• Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation.

  Experimental & molecular medicine 20120531

• Structural evaluation of probucol nanoparticles in water by atomic force microscopy.

  International journal of pharmaceutics 20120510

• Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism.

  Journal of pharmaceutical sciences 20120501

• Development of a probucol-releasing antithrombogenic drug eluting stent.

  Journal of biomedical materials research. Part B, Applied biomaterials 20120501

• ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.

  Journal of lipid research 20120501

• [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120501

• Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury.

  Clinical and experimental nephrology 20120401

• Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1: a novel mechanism of QT prolongation.

  Journal of cardiovascular pharmacology 20120401

• Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro.

  Brain research bulletin 20120310

• Probucol: can we step forward in atherosclerosis prevention with an old drug?

  Atherosclerosis 20120301

• Succinobucol induces apoptosis in vascular smooth muscle cells.

  Free radical biology & medicine 20120301

• Anti-hypercholesterolemic and anti-atherosclerotic effects of polarized-light therapy in rabbits fed a high-cholesterol diet.

  Laboratory animal research 20120301

• Molecular-level characterization of probucol nanocrystal in water by in situ solid-state NMR spectroscopy.

  International journal of pharmaceutics 20120227

• Probucol and atorvastatin in combination protect rat brains in MCAO model: upregulating Peroxiredoxin2, Foxo3a and Nrf2 expression.

  Neuroscience letters 20120216

• Comparison of high-resolution ultrasonic resonator technology and Raman spectroscopy as novel process analytical tools for drug quantification in self-emulsifying drug delivery systems.

  Journal of pharmaceutical and biomedical analysis 20120205

• Probucol therapy improves long-term (>10-year) survival after complete revascularization: a propensity analysis.

  Atherosclerosis 20120201

• Probucol, a lipid-lowering drug, prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice.

  Experimental neurology 20120201

• Impact of short-duration administration of N-acetylcysteine, probucol and ascorbic acid on contrast-induced cytotoxicity.

  Journal of nephrology 20120101

• Probucol suppresses enterocytic accumulation of amyloid-β induced by saturated fat and cholesterol feeding.

  Lipids 20120101

• The oxidative state of chylomicron remnants influences their modulation of human monocyte activation.

  International journal of vascular medicine 20120101

• Modulation of fibrosis in systemic sclerosis by nitric oxide and antioxidants.

  Cardiology research and practice 20120101

• Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation.

  International journal of nanomedicine 20120101

• Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts.

  PloS one 20120101

• ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier.

  Journal of Alzheimer's disease : JAD 20120101

• Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.

  Nutrition & metabolism 20120101

• Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.

  International journal of Alzheimer's disease 20120101

• Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms.

  Oxidative medicine and cellular longevity 20120101

• Low-dose fluvastatin prevents the functional alterations of endothelium induced by short-term cholesterol feeding in rabbit carotid artery.

  TheScientificWorldJournal 20120101

• Novel Aspects of Nonfasting Lipemia in relation to Vascular Biology.

  International journal of vascular medicine 20120101

• Detrimental effects of non-functional spermatozoa on the freezability of functional spermatozoa from boar ejaculate.

  PloS one 20120101

• Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly?

  Frontiers in pharmacology 20120101

• Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study.

  International journal of nanomedicine 20120101

• Quercetin and epigallocatechin gallate induce in vitro a dose-dependent stiffening and hyperpolarizing effect on the cell membrane of human mononuclear blood cells.

  International journal of molecular sciences 20120101

• Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.

  International journal of vascular medicine 20120101

• Urinary markers of glomerular injury in diabetic nephropathy.

  International journal of nephrology 20120101

• Oxidative stress and heart failure in altered thyroid States.

  TheScientificWorldJournal 20120101

• LDL-apheresis: technical and clinical aspects.

  TheScientificWorldJournal 20120101

• The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells.

  Experimental diabetes research 20120101

• Progress in pathogenesis of proteinuria.

  International journal of nephrology 20120101

• Cardioprotective effect of sodium ferulate in diabetic rats.

  International journal of medical sciences 20120101

• Effect of probucol on antioxidant properties of HDL in patients with heterozygous familial hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20120101

• Epithelial-to-mesenchymal transdifferentiation of renal tubular epithelial cell mediated by oxidative stress and intervention effect of probucol in diabetic nephropathy rats.

  Renal failure 20120101

• Clinical spectrum and therapy of non-alcoholic steatohepatitis.

  Digestive diseases (Basel, Switzerland) 20120101

• Redox pioneer: professor Roland Stocker.

  Antioxidants & redox signaling 20111215

• In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish.

  The Journal of clinical investigation 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• N-acetylcysteine for Prevention of Contrast-Induced Nephropathy: A Narrative Review.

  Korean circulation journal 20111201

• Succinobucol's new coat--conjugation with steroids to alter its drug effect and bioavailability.

  Molecules (Basel, Switzerland) 20111110

• Chance and serendipity in science: two examples from my own career.

  The Journal of biological chemistry 20111104

• Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood-brain barrier.

  Molecular and cellular biochemistry 20111101

• Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein.

  Atherosclerosis 20111101

• Pharmacokinetics and tolerability of probucol after multiple oral administrations in healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20111101

• The effects of statin and niacin on plaque stability, plaque regression, inflammation and oxidative stress in patients with mild to moderate coronary artery stenosis.

  Korean circulation journal 20111101

• [Efficacy observation of combination of Lumbrukinase Capsule and Probucol Tablet in treating cerebral infarction patients' unstable atheromatous plaque of the carotid artery].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20111101

• Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport.

  Circulation 20110920

• Probucol attenuates inflammation and increases stability of vulnerable atherosclerotic plaques in rabbits.

  The Tohoku journal of experimental medicine 20110901

• Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents.

  Journal of medicinal chemistry 20110811

• Polymer-free sirolimus- and probucol-eluting versus new generation zotarolimus-eluting stents in coronary artery disease: the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol-Eluting versus Zotarolimus-eluting Stents (ISAR-TEST 5) trial.

  Circulation 20110802

• Combinatorial effect of probucol and cilostazol in focal ischemic mice with hypercholesterolemia.

  The Journal of pharmacology and experimental therapeutics 20110801

• Possible role for the thioredoxin system in the protective effects of probucol in the pancreatic islets of diabetic rats.

  Clinical and experimental pharmacology & physiology 20110801

• Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil.

  Arquivos brasileiros de cardiologia 20110801

• Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice.

  EMBO molecular medicine 20110701

• Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation.

  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110701

• The cardioprotective role of probucol against anthracycline and trastuzumab-mediated cardiotoxicity.

  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20110601

• Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study.

  Chinese medical journal 20110601

• Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression.

  Molecular pharmacology 20110501

• An eight-week trial investigating the efficacy and tolerability of atorvastatin for children and adolescents with heterozygous familial hypercholesterolemia.

  Pediatric cardiology 20110401

• [Stability of probucol-polyvinylpyrrolidone solid dispersion systems].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401

• A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110318

• Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids.

  Free radical research 20110301

• Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dependent on their uptake by the low density lipoprotein receptor.

  Biochimica et biophysica acta 20110301

• Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism.

  Atherosclerosis 20110301

• Two-year clinical outcome after carvedilol-loaded stent implantation in patients with coronary artery disease.

  The Korean journal of internal medicine 20110301

• Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits.

  Journal of the science of food and agriculture 20110115

• Dietary fatty acids and oxidative stress in the heart mitochondria.

  Mitochondrion 20110101

• Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat.

  Advances in urology 20110101

• [Novel therapy for atherosclerosis and inflammatory vascular disease].

  Nihon rinsho. Japanese journal of clinical medicine 20110101

• Study design and rationale of 'Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)' study: a double-blind randomised controlled multicenter clinical trial.

  Trials 20110101

• Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion.

  BMC complementary and alternative medicine 20110101

• Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults.

  Nutrition & metabolism 20110101

• Cilostazol improves symptomatic intracranial artery stenosis - Evaluation of cerebral blood flow with single photon emission computed tomography.

  Surgical neurology international 20110101

• Epithelial-to-mesenchymal transdifferentiation of peritoneal mesothelial cells mediated by oxidative stress in peritoneal fibrosis rats.

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110101

• Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective.

  Vascular cell 20110101

• Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases.

  Journal of biomedicine & biotechnology 20110101

• Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.

  Diabetologia 20110101

• Function and comorbidities of apolipoprotein e in Alzheimer's disease.

  International journal of Alzheimer's disease 20110101

• Oxidative stress and redox modulation potential in type 1 diabetes.

  Clinical & developmental immunology 20110101

• Malignancy-associated dyslipidemia.

  The open cardiovascular medicine journal 20110101

• Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose.

  Molecular medicine reports 20110101

• Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?

  International journal of inflammation 20110101

• Liposomal Antioxidants for Protection against Oxidant-Induced Damage.

  Journal of toxicology 20110101

• Probucol attenuates oxidative stress, energy starvation, and nitric acid production following transient forebrain ischemia in the rat hippocampus.

  Oxidative medicine and cellular longevity 20110101

• Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study.

  BMC complementary and alternative medicine 20110101

• Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats.

  Pharmacognosy research 20110101

• Probucol alleviates atherosclerosis and improves high density lipoprotein function.

  Lipids in health and disease 20110101

• Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts.

  The Journal of toxicological sciences 20110101

• Bioactive constituents and medicinal importance of genus Alnus.

  Pharmacognosy reviews 20110101

• [Panavir in combined treatment of chronic cystitis with hyperplastic changes in urinary bladder mucosa].

  Urologiia (Moscow, Russia : 1999) 20110101

• No consensus on definition criteria for stroke registry common data elements.

  Cerebrovascular diseases extra 20110101

• Statins: past and present.

  Heart views : the official journal of the Gulf Heart Association 20110101

• Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia.

  Circulation research 20101210

• A predictive ligand-based Bayesian model for human drug-induced liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20101201

• Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice.

  American journal of physiology. Endocrinology and metabolism 20101201

• Antioxidant interventions as novel preventive strategies for postoperative atrial fibrillation.

  International journal of cardiology 20101105

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Design of more potent squalene synthase inhibitors with multiple activities.

  Bioorganic & medicinal chemistry 20101101

• A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats.

  Journal of clinical biochemistry and nutrition 20101101

• Lipid rafts and redox regulation of cellular signaling in cholesterol induced atherosclerosis.

  Current cardiology reviews 20101101

• Probucol and succinobucol in atrial fibrillation: pros and cons.

  International journal of cardiology 20101008

• Transglycosylated stevia and hesperidin as pharmaceutical excipients: dramatic improvement in drug dissolution and bioavailability.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

• Chlorogenic acid attenuates adhesion molecules upregulation in IL-1beta-treated endothelial cells.

  European journal of nutrition 20100801

• Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20100730

• AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

  Molecular and cellular endocrinology 20100729

• Effects of atorvastatin versus probucol on low-density lipoprotein subtype distribution and renal function in hyperlipidemic patients with nondiabetic nephropathy.

  Renal failure 20100701

• Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.

  Cardiovascular research 20100601

• Post-prandial lipid metabolism, lipid-modulating agents and cerebrovascular integrity: implications for dementia risk.

  Atherosclerosis. Supplements 20100601

• [Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk].

  Rinsho byori. The Japanese journal of clinical pathology 20100601

• ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion.

  The Journal of nutritional biochemistry 20100501

• Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.

  British journal of cancer 20100427

• The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20100401

• Effects of grape pomace on the antioxidant defense system in diet-induced hypercholesterolemic rabbits.

  Nutrition research and practice 20100401

• Cross-platform expression microarray performance in a mouse model of mitochondrial disease therapy.

  Molecular genetics and metabolism 20100301

• Probucol and antioxidant vitamins rescue ischemia-induced neovascularization in mice exposed to cigarette smoke: potential role of endothelial progenitor cells.

  Atherosclerosis 20100201

• Homogeneous nanoparticles to enhance the efficiency of a hydrophobic drug, antihyperlipidemic probucol, characterized by solid-state NMR.

  Molecular pharmaceutics 20100201

• Vitamin E prevents steroid-induced osteonecrosis in rabbits.

  Acta orthopaedica 20100201

• Antioxidant therapy reverses impaired graft healing in hypercholesterolemic rabbits.

  Journal of vascular surgery 20100101

• Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.

  International journal of molecular sciences 20100101

• Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.

  Mediators of inflammation 20100101

• Janus kinase 2/signal transducers and activators of transcription signal inhibition regulates protective effects of probucol on mesangial cells treated with high glucose.

  Biological & pharmaceutical bulletin 20100101

• Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes.

  Reproductive biology and endocrinology : RB&E 20100101

• Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.

  Nutrition journal 20100101

• Variability of serum oxidative stress biomarkers relative to biochemical data and clinical parameters of glaucoma patients.

  Molecular vision 20100101

• Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.

  Cardiology research and practice 20100101

• Methylguanidine cytotoxicity on HK-2 cells and protective effect of antioxidants against MG-induced apoptosis in renal proximal tubular cells in vitro.

  Renal failure 20100101

• [Immunocorrecting therapy of chronic bacterial prostatitis].

  Urologiia (Moscow, Russia : 1999) 20100101

• Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting.

  Lipids in health and disease 20100101

• High-density lipoprotein therapeutics and cardiovascular prevention.

  Journal of clinical lipidology 20100101

• Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.

  PloS one 20100101

• Low high-density lipoprotein cholesterol: current status and future strategies for management.

  Vascular health and risk management 20100101

• Use of hamster as a model to study diet-induced atherosclerosis.

  Nutrition & metabolism 20100101

• Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues.

  Oxidative medicine and cellular longevity 20100101

• Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.

  International journal of molecular sciences 20100101

• Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

  The open cardiovascular medicine journal 20100101

• Metabolic clues: novel directives for broad treatment strategies.

  Oxidative medicine and cellular longevity 20100101

• Update on the role of candesartan in the optimal management of hypertension and cardiovascular risk reduction.

  Integrated blood pressure control 20100101

• Development, characterization and solubility study of solid dispersions of azithromycin dihydrate by solvent evaporation method.

  Journal of advanced pharmaceutical technology & research 20100101

• Development, characterization and solubility study of solid dispersions of Cefuroxime Axetil by the solvent evaporation method.

  Journal of advanced pharmaceutical technology & research 20100101

• Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E.

  Biochemistry 20091222

• Improvement of nephrotic syndrome by intensive lipid-lowering therapy in a patient with lipoprotein glomerulopathy.

  Clinical and experimental nephrology 20091201

• Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20091201

• Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL).

  American journal of physiology. Gastrointestinal and liver physiology 20091201

• Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells.

  Cardiovascular drugs and therapy 20091201

• Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1.

  Biochemistry 20091124

• Where are we with probucol: a new life for an old drug?

  Atherosclerosis 20091101

• Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.

  Journal of lipid research 20091101

• Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide.

  Cardiovascular research 20091101

• Pharmacologic therapy of non-alcoholic steatohepatitis.

  Clinics in liver disease 20091101

• Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.

  Diabetes care 20091101

• Enhanced bioavailability of probucol following the administration of solid dispersion systems of probucol-polyvinylpyrrolidone in rabbits.

  Biological & pharmaceutical bulletin 20091101

• Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome.

  Microcirculation (New York, N.Y. : 1994) 20091101

• Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liver.

  Atherosclerosis 20091001

• Heme oxygenase-1 increases endothelial progenitor cells.

  Arteriosclerosis, thrombosis, and vascular biology 20091001

• A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicity.

  Canadian journal of physiology and pharmacology 20091001

• Potential interactions between cilostazol and probucol: a two-part, single-dose, open-label study in healthy Korean male volunteers.

  Clinical therapeutics 20091001

• [Effects of atorvastatin, alone and in combination with probucol on endothelial function in patients with acute coronary syndrome].

  Zhonghua xin xue guan bing za zhi 20091001

• Computer diagnosis in cardiology: oxidative stress hypothesis.

  North American journal of medical sciences 20091001

• Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling.

  American journal of physiology. Cell physiology 20090901

• Antiphospholipid antibodies in systemic sclerosis: a double oxidative hit?

  Clinical rheumatology 20090801

• Antioxidant probucol attenuates myocardial oxidative stress and collagen expressions in post-myocardial infarction rats.

  Journal of cardiovascular pharmacology 20090801

• Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

  Current cardiology reviews 20090801

• [Effects of probucol, aspirin and atorvastatin combination therapy upon atherosclerosis].

  Zhonghua yi xue za zhi 20090728

• Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture.

  International journal of pharmaceutics 20090706

• Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.

  Naunyn-Schmiedeberg's archives of pharmacology 20090701

• Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia.

  The American journal of the medical sciences 20090701

• Influence of T-calcium channel blocker treatment on deterioration of renal function in chronic kidney disease.

  Heart and vessels 20090701

• Effects of N-acetyl-cysteine on endothelial function and inflammation in patients with type 2 diabetes mellitus.

  Heart international 20090630

• Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.

  Journal of gastroenterology and hepatology 20090601

• Cytotoxicity of 5-fluorouracil: Effect on endothelial differentiation via cell cycle inhibition in mouse embryonic stem cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues.

  Current opinion in lipidology 20090601

• Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress.

  Microbiology and immunology 20090601

• Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

  Journal of thrombosis and thrombolysis 20090501

• Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review.

  Journal of pediatric gastroenterology and nutrition 20090501

• [Role of probucol in preventing contrast induced acute kidney injury after coronary interventional procedure: a randomized trial].

  Zhonghua xin xue guan bing za zhi 20090501

• Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.

  Biochemical and biophysical research communications 20090403

• A polymer-free dual drug-eluting stent in patients with coronary artery disease: a randomized trial vs. polymer-based drug-eluting stents.

  European heart journal 20090401

• Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects.

  Expert opinion on investigational drugs 20090401

• Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management.

  Journal of clinical medicine research 20090401

• Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1.

  Circulation research 20090313

• Role of probucol in preventing contrast-induced acute kidney injury after coronary interventional procedure.

  The American journal of cardiology 20090215

• The pre-clinical assessment of rapamycin-eluting, durable polymer-free stent coating concepts.

  Biomaterials 20090201

• Activation of hepatic lipase expression by oleic acid: possible involvement of USF1.

  Nutrients 20090201

• Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing.

  Chinese medical journal 20090105

• Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.

  European journal of nuclear medicine and molecular imaging 20090101

• Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis.

  BMJ (Clinical research ed.) 20090101

• Nanoparticle processing in the solid state dramatically increases the cell membrane permeation of a cholesterol-lowering drug, probucol.

  Molecular pharmaceutics 20090101

• Alpha-tocopherol: looking beyond an antioxidant.

  Molecular vision 20090101

• [Antiviral activity of panavir in experimental Measles virus infection in cell cultures].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• [Preclinical and clinical studies of the efficacy of Panavir in therapy for tick-borne encephalitis].

  Voprosy virusologii 20090101

• The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials.

  BMJ (Clinical research ed.) 20090101

• [Coronary artery bypass graft in adolescent suffering from homozygous familial hypercholesterolemia resistant to probucol therapy].

  Le Mali medical 20090101

• [Effect of Panavir on Herpes simplex virus types 1 and 2 proteins synthesis in cell culture].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• Anti-atherosclerotic molecules targeting oxidative stress and inflammation.

  Current pharmaceutical design 20090101

• [Protective activity of panavir in experimental rabies infection].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

• [A case of type 2 diabetes mellitus associated with familial hypercholesterolemia confirming the improvement of blood glucose control by colestimide].

  Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20090101

• Influence of aging on gastric ulcer healing activities of the antioxidants alpha-tocopherol and probucol.

  European journal of pharmacology 20081228

• Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits.

  The Journal of rheumatology 20081201

• Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan.

  Journal of atherosclerosis and thrombosis 20081201

• A uniqe antilipidemic drug--probucol.

  Journal of atherosclerosis and thrombosis 20081201

• [Effect of xiongshao capsule on lipid metabolism and platelet aggregation in experimental atherosclerosis rabbits].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081201

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling.

  Atherosclerosis 20081001

• N-acetylcysteine protects against renal injury following bilateral ureteral obstruction.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081001

• [Effects of Xiongshao capsule on the proliferation of vascular smooth muscle cells in rabbits with atherosclerosis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081001

• Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy.

  Journal of cancer research and clinical oncology 20080901

• Chylomicrons in disease-future challenges Invited keynote address.

  Atherosclerosis. Supplements 20080901

• Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis.

  Journal of clinical biochemistry and nutrition 20080901

• Preparation, characterization and optimization of probucol self-emulsified drug delivery system to enhance solubility and dissolution.

  Die Pharmazie 20080901

• Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model.

  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20080901

• Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.

  Journal of medicinal chemistry 20080814

• Liver histology changes in nonalcoholic steatohepatitis after one year of treatment with probucol.

  Digestive diseases and sciences 20080801

• In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

• Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy.

  Pediatric nephrology (Berlin, Germany) 20080801

• In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080801

• Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit.

  Cardiovascular drugs and therapy 20080801

• Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cells.

  The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080801

• Antiatherogenic effects of cilostazol and probucol alone, and in combination in low density lipoprotein receptor-deficient mice fed with a high fat diet.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080701

• Development of novel antiatherogenic biaryls: design, synthesis, and reactivity.

  Journal of medicinal chemistry 20080612

• Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601

• Morphology and surface States of colloidal probucol nanoparticles evaluated by atomic force microscopy.

  Chemical & pharmaceutical bulletin 20080601

• [Advance in the study of compounds inducing the expression of heme oxygenase-1].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080601

• Novel cardiac therapies and innocent by standers.

  Lancet (London, England) 20080524

• Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20080524

• [Influence of oxidative stress on atrial myocardium pathohistological and ultrastructural changes in atrial fibrillation: experiment with dogs].

  Zhonghua yi xue za zhi 20080408

• Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

  International journal of pharmaceutics 20080320

• Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.

  Atherosclerosis 20080301

• Expression and biological activity of ABCA1 in alveolar epithelial cells.

  American journal of respiratory cell and molecular biology 20080301

• In vivo assessment of oral administration of probucol nanoparticles in rats.

  Biological & pharmaceutical bulletin 20080201

• Effect of the anti-oxidant probucol on soluble thrombomodulin (sTM) in hypercholesterolemic rabbits.

  International journal of cardiology 20080111

• Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities?

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20080101

• Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.

  Bioorganic & medicinal chemistry letters 20080101

• RNAi for treating hepatitis B viral infection.

  Pharmaceutical research 20080101

• Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.

  Redox report : communications in free radical research 20080101

• [Effects of Xiongshao capsule on blood vessel collagenase gene expression in experimental rabbits with arterial restenosis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080101

• Viability of developing CETP inhibitors.

  Cardiovascular therapeutics 20080101

• Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30.

  Pharmaceutical development and technology 20080101

• Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice.

  PloS one 20080101

• [Investigation of antiviral properties of new formulations of Panavir in the treatment of experimental herpes virus infection in mice].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

• Pharmacologic induction of heme oxygenase-1.

  Antioxidants & redox signaling 20071201

• Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.

  Free radical biology & medicine 20071201

• Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.

  Cardiovascular drugs and therapy 20071201

• hERG channel trafficking: novel targets in drug-induced long QT syndrome.

  Biochemical Society transactions 20071101

• Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.

  Bulletin of experimental biology and medicine 20071101

• [Adverse effects of lipid-lowering medications].

  Nihon rinsho. Japanese journal of clinical medicine 20071028

• Probucol modulates iron nitrilotriacetate (Fe-NTA)-dependent renal carcinogenesis and hyperproliferative response: diminution of oxidative stress.

  Molecular and cellular biochemistry 20071001

• Combined pantethine and probucol therapy for Japanese patients with non-alcoholic steatohepatitis.

  Hepatology research : the official journal of the Japan Society of Hepatology 20071001

• Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans.

  Current drug metabolism 20071001

• Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents.

  Bioorganic & medicinal chemistry 20070915

• Probucol mediates vascular remodeling after percutaneous transluminal angioplasty via down-regulation of the ERK1/2 signaling pathway.

  European journal of pharmacology 20070910

• Pharmacologic approaches to restenosis prevention.

  The American journal of cardiology 20070903

• Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells.

  Diabetes research and clinical practice 20070901

• Bioassay-guided fractionation of antifertility components of castorbean (Ricinus communis L.) seed extracts.

  Natural product research 20070901

• Probucol does not inhibit myeloperoxidase-dependent low-density lipoprotein oxidation as a potent protective effect in atherosclerosis.

  Journal of cardiovascular pharmacology 20070901

• Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185.

  Current oncology (Toronto, Ont.) 20070801

• Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.

  Journal of clinical lipidology 20070801

• [Probucol].

  Nihon rinsho. Japanese journal of clinical medicine 20070728

• [Drug-induced hypolipoproteinemia].

  Nihon rinsho. Japanese journal of clinical medicine 20070728

• Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats.

  Brain research 20070709

• Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.

  Biochimica et biophysica acta 20070701

• Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice.

  Biochimica et biophysica acta 20070701

• AGI-1067, a novel vascular protectant, anti-inflammatory drug and mild antiplatelet agent for treatment of atherosclerosis.

  Expert review of cardiovascular therapy 20070701

• Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide.

  Journal of clinical biochemistry and nutrition 20070701

• The MeOH extract of Pleurospermum kamtschaticum and its active component buddlejasaponin (IV) inhibits intrinsic and extrinsic hyperlipidemia and hypercholesterolemia in the rat.

  Journal of ethnopharmacology 20070613

• Anticancer prodrugs of butyric acid and formaldehyde protect against doxorubicin-induced cardiotoxicity.

  British journal of cancer 20070604

• Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

  The Journal of pharmacology and experimental therapeutics 20070601

• Mechanisms involved in chylomicron remnant lipid uptake by macrophages.

  Biochemical Society transactions 20070601

• [Animal models for steroid-induced osteonecrosis].

  Clinical calcium 20070601

• Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice.

  The Journal of pharmacology and experimental therapeutics 20070501

• Follicular development and expression of the messenger ribonucleic acid for the inhibin/activin subunits in two genetic lines of turkey hens that differ in total egg production.

  Poultry science 20070501

• Cloning and expression of human haptoglobin subunits in Escherichia coli: delineation of a major antioxidant domain.

  Protein expression and purification 20070401

• Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds.

  Journal of pharmaceutical sciences 20070401

• Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials.

  Hypertension (Dallas, Tex. : 1979) 20070401

• Effects of acetylcysteine and probucol on contrast medium-induced depression of intrinsic renal glutathione peroxidase activity in diabetic rats.

  Archives of medical research 20070401

• Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis?

  International journal of clinical practice 20070401

• [Research and developmental strategy of anti-dyslipidemic agents].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401

• Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20070401

• Oral treatment with probucol in a pharmacological dose has no beneficial effects on mortality in chronic ischemic heart failure after large myocardial infarction in rats.

  European journal of pharmacology 20070308

• Antioxidant nature of bovine milk beta-lactoglobulin.

  Journal of dairy science 20070201

• Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage.

  Cardiovascular drugs and therapy 20070201

• Effect of probucol on HDL metabolism and class B type I scavenger receptor (SR-BI) expression in the liver of hypercholesterolemic rabbits.

  International journal of cardiology 20070131

• American Heart Association - Scientific Sessions 2006. Cell therapies for ischemic tissues and treatments for lipid metabolism disorders.

  IDrugs : the investigational drugs journal 20070101

• Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats.

  Redox report : communications in free radical research 20070101

• Probucol promotes endogenous antioxidant reserve and confers protection against reperfusion injury.

  Canadian journal of physiology and pharmacology 20070101

• Inhibition of lipid peroxidation induced by hydroxyprogesterone caproate by some conventional antioxidants in goat liver homogenates.

  Acta poloniae pharmaceutica 20070101

• Are HIV positive patients resistant to statin therapy?

  Lipids in health and disease 20070101

• Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects.

  Lipids in health and disease 20070101

• [Panavir, as a broad spectrum antiviral agent].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101

• Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization.

  Atherosclerosis 20061201

• Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.

  Cardiovascular & hematological disorders drug targets 20061201

• Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia.

  American journal of physiology. Heart and circulatory physiology 20061101

• Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR.

  Pharmaceutical research 20061101

• Role of probucol in inhibiting intimal hyperplasia after coronary stent implantation: a randomized study.

  American heart journal 20061101

• Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20061101

• Combined effect of probucol and insulin on renal damage in diabetic rats fed a high cholesterol diet.

  European journal of pharmacology 20061024

• [Can antioxidants prevent atherosclerosis?].

  Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20061001

• Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.

  Journal of cardiovascular pharmacology 20061001

• Human urotensin-II potentiates the mitogenic effect of mildly oxidized low-density lipoprotein on vascular smooth muscle cells: comparison with other vasoactive agents and hydrogen peroxide.

  Hypertension research : official journal of the Japanese Society of Hypertension 20061001

• Dietary phytosterols reduce probucol-induced atherogenesis in apo E-KO mice.

  Atherosclerosis 20060901

• The in vitro effects of a novel vascular protectant, AGI-1067, on platelet aggregation and major receptor expression in subjects with multiple risk factors for vascular disease.

  Journal of cardiovascular pharmacology and therapeutics 20060901

• Tripterine inhibits the expression of adhesion molecules in activated endothelial cells.

  Journal of leukocyte biology 20060801

• Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity.

  Cardiovascular drugs and therapy 20060801

• Both hepatitis C virus and Chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy.

  Fukuoka igaku zasshi = Hukuoka acta medica 20060801

• Protective effect of calceolarioside on adriamycin-induced cardiomyocyte toxicity.

  European journal of pharmacology 20060710

• Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe.

  European journal of pharmacology 20060701

• [Beneficial effects of probucol on endothelial function in patients with acute coronary syndrome].

  Zhonghua xin xue guan bing za zhi 20060701

• Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies.

  Diabetologia 20060601

• CETP levels rather than polymorphisms as markers of coronary risk: healthy athlete with high HDL-C and coronary disease--effectiveness of probucol.

  Atherosclerosis 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Are small biotechs still underselling themselves?

  Nature biotechnology 20060501

• [Effects of xuezhikang capsules on vascular endothelial function and redox status in patients with coronary heart disease].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060501

• Phenolic compounds from the roots of Lindera fruticosa.

  Journal of natural products 20060501

• Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy.

  Journal of cardiovascular pharmacology 20060501

• [Effect of probucol and losartan on growth factors after balloon angioplasty in rabbits].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060401

• LDL-antioxidant pterocarpans from roots of Glycine max (L.) Merr.

  Journal of agricultural and food chemistry 20060322

• Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20060301

• Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat.

  Journal of the American Society of Nephrology : JASN 20060301

• Determination of DPPH free radical scavenging activity by reversed-phase HPLC: a sensitive screening method for polyherbal formulations.

  Journal of pharmaceutical and biomedical analysis 20060213

• Probucol delays progression of diabetic nephropathy.

  Diabetes research and clinical practice 20060201

• Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.

  Natural product research 20060201

• Antioxidants: the good, the bad and the ugly.

  The Canadian journal of cardiology 20060201

• Probucol and atorvastatin decrease urinary 8-hydroxy-2'-deoxyguanosine in patients with diabetes and hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20060201

• Drug nanoparticle formation from drug/HPMC/SDS ternary ground mixtures.

  Die Pharmazie 20060201

• Review article: Drug therapy for non-alcoholic fatty liver disease.

  Alimentary pharmacology & therapeutics 20060115

• Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice.

  Arteriosclerosis, thrombosis, and vascular biology 20060101

• Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation.

  Natural product research 20060101

• Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element.

  Free radical research 20060101

• AGI-1067: a novel vascular protectant for prevention of restenosis.

  The Annals of pharmacotherapy 20060101

• Probucol up-regulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits.

  Journal of cardiovascular pharmacology 20060101

• Evaluation of the rabbit Purkinje fibre assay as an in vitro tool for assessing the risk of drug-induced torsades de pointes in humans.

  Drug safety 20060101

• Effect of probucol on elderly hypercholesterolemic patients in the FAST study.

  Fukuoka igaku zasshi = Hukuoka acta medica 20060101

• Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits.

  Pathology, research and practice 20060101

• Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.

  Annual review of nutrition 20060101

• Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.

  BMC neuroscience 20060101

• [Interaction between dinitrosyl iron complexes and intermediate products of oxidative stress].

  Biofizika 20060101

• Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma.

  International archives of allergy and immunology 20060101

• The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.

  Lipids in health and disease 20060101

• Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats.

  BMC gastroenterology 20060101

• Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion.

  Scandinavian journal of clinical and laboratory investigation 20060101

• [The role of epsilon 2/epsilon 3/epsilon 4 polymorphism of the apolipoprotein E gene in the development of dislipoproteinemia and its influence on the efficacy of the hypolipidemic therapy].

  TSitologiia i genetika 20060101

• Dietary probucol preserves endothelium-dependent relaxation of arteriovenous fistula in hypercholesterolemic rabbits.

  Chang Gung medical journal 20060101

• Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials.

  Chinese medicine 20060101

• Inhibition of vascular remodelling in a porcine coronary injury model by herbal extract XS0601.

  Chinese medicine 20060101

• [Effect of Panavir on influenza A virus reproduction].

  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20060101

• Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.

  The Journal of biological chemistry 20051230

• Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents.

  Journal of medicinal chemistry 20051229

• [Oxidative stress and cardiovascular diseases].

  Deutsche medizinische Wochenschrift (1946) 20051216

• Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051201

• Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats.

  Journal of nutritional science and vitaminology 20051201

• Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid.

  The Journal of nutritional biochemistry 20051101

• Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism.

  Arteriosclerosis, thrombosis, and vascular biology 20051101

• In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.

  Journal of neurosurgery 20051001

• Ten-year follow-up of familial hypercholesterolemia patients after intensive cholesterol-lowering therapy.

  International heart journal 20050901

• A case of familial hypercholesterolemia; secession from LDL-apheresis by the drug treatment with potent statin and resin.

  The Tokai journal of experimental and clinical medicine 20050901

• Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice.

  Arteriosclerosis, thrombosis, and vascular biology 20050801

• Enzymatic characterization of lipid-based drug delivery systems.

  International journal of pharmaceutics 20050725

• Cholesterol levels and statin use in patients with coronary heart disease treated in primary care settings.

  Preventing chronic disease 20050701

• [Long QT syndrome].

  Nihon rinsho. Japanese journal of clinical medicine 20050701

• Study of antiparkinsonic activity of panavir on a model of Parkinson syndrome induced by systemic administration of MPTP to outbred rats and C57Bl/6 mice.

  Bulletin of experimental biology and medicine 20050701

• Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants.

  Vascular health and risk management 20050601

• AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

  The Journal of pharmacology and experimental therapeutics 20050501

• Effort angina in a middle-aged woman with abnormally high levels of serum high-density lipoprotein cholesterol: a case of cholesteryl-ester transfer protein deficiency.

  Circulation journal : official journal of the Japanese Circulation Society 20050501

• Reduction of oxidative stress and atherosclerosis in hyperlipidemic rabbits by Dioscorea rhizome.

  Canadian journal of physiology and pharmacology 20050501

• Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate.

  The Journal of biological chemistry 20050422

• Combined effect of probucol and insulin on cataracts of diabetic rats fed a high cholesterol diet.

  European journal of pharmacology 20050418

• Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat.

  Pharmacological research 20050401

• Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.

  Molecular nutrition & food research 20050401

• Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy.

  American journal of physiology. Heart and circulatory physiology 20050401

• Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits.

  Atherosclerosis 20050401

• Na+/H+ exchange inhibition and antioxidants lack additive protective effects after reperfusion injury in the working heterotopic rat heart isograft.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050401

• Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease.

  Neurobiology of aging 20050301

• Antioxidants and atherosclerosis: emerging drug therapies.

  Current atherosclerosis reports 20050201

• Low daily dose of antioxidant probucol decreases incidence and severity of restenosis after transluminal coronary balloon angioplasty.

  Bulletin of experimental biology and medicine 20050201

• On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway.

  Journal of lipid research 20050101

• Effect of anti-oxidant (carvedilol and probucol) loaded stents in a porcine coronary restenosis model.

  Circulation journal : official journal of the Japanese Circulation Society 20050101

• Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release.

  BMC neuroscience 20050101

• Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism.

  BMC neuroscience 20050101

• Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.

  Journal of atherosclerosis and thrombosis 20050101

• Oxidative stress and pancreatic beta-cell dysfunction.

  American journal of therapeutics 20050101

• Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: comparison with probucol.

  Journal of biochemical and molecular toxicology 20050101

• Inhibition of lipoprotein lipid oxidation.

  Handbook of experimental pharmacology 20050101

• Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

  Journal of medicinal chemistry 20041202

• Probucol inhibits ABCA1-mediated cellular lipid efflux.

  Arteriosclerosis, thrombosis, and vascular biology 20041201

• Effects of probucol versus aspirin and versus brachytherapy on restenosis after femoropopliteal angioplasty: the PAB randomized multicenter trial.

  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20041201

• Antioxidant activities of a new lignan and a neolignan from Saururus chinensis.

  Bioorganic & medicinal chemistry letters 20041115

• Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells.

  Arteriosclerosis, thrombosis, and vascular biology 20041101

• Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101

• HMG CoA reductase inhibitors (statins) for dialysis patients.

  The Cochrane database of systematic reviews 20041018

• 3,4,5,6-Tetrahydroxyxanthone prevents vascular endothelial cell apoptosis induced by high glucose.

  Naunyn-Schmiedeberg's archives of pharmacology 20041001

• Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.

  Clinical rheumatology 20041001

• Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits.

  Arthritis and rheumatism 20041001

• Concurrent therapies that protect against doxorubicin-induced cardiomyopathy.

  Clinical journal of oncology nursing 20041001

• Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.

  Circulation 20040928

• Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size.

  Bioorganic & medicinal chemistry letters 20040920

• [NO and atherosclerosis].

  Nihon rinsho. Japanese journal of clinical medicine 20040901

• [Study of diagnostic criteria of intima-media thickening and effects of drugs on peripheral arteries].

  Zhonghua yi xue za zhi 20040802

• Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.

  Clinical science (London, England : 1979) 20040801

• Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation.

  Bioorganic & medicinal chemistry 20040801

• Antioxidant role of human haptoglobin.

  Proteomics 20040801

• Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases.

  Acta pharmacologica Sinica 20040801

• Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation.

  The Journal of biological chemistry 20040716

• Oligodendrocytes are susceptible to apoptotic cell death induced by prion protein-derived peptides.

  Glia 20040701

• Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor.

  Bioorganic & medicinal chemistry letters 20040607

• Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes.

  Atherosclerosis 20040601

• Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.

  American journal of hypertension 20040601

• Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells.

  European journal of biochemistry 20040601

• Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice.

  Pharmaceutical research 20040601

• Acteoside protects endothelial cells against free radical-induced oxidative stress.

  The Journal of pharmacy and pharmacology 20040601

• New drugs to improve transplant outcomes.

  Transplantation 20040515

• Carvedilol inhibits basal and stimulated ACE production in human endothelial cells.

  Journal of cardiovascular pharmacology 20040501

• Effect of probucol on the oral bioavailability of cyclosporine A.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040501

• Long-term treatment with probucol improves endothelial function in patients with coronary artery disease.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040501

• Liquid chromatographic method for the simultaneous determination of different lipid-soluble antioxidants in human plasma and low-density lipoproteins.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

• Regulation of mitochondrial transcription factor A expression by high glucose.

  Annals of the New York Academy of Sciences 20040401

• [Effect of xiongshao capsule on vascular remodeling in rabbit with experimental atherosclerosis].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040401

• Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.

  The Journal of biological chemistry 20040312

• Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

  The Journal of pharmacology and experimental therapeutics 20040301

• Redox processes underlying the vascular repair reaction.

  World journal of surgery 20040301

• Effect of probucol on neointimal thickening in a stent porcine restenosis model.

  Japanese heart journal 20040301

• Protective mechanisms against peptide and protein peroxides generated by singlet oxygen.

  Free radical biology & medicine 20040215

• Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.

  The Journal of biological chemistry 20040206

• Potent antioxidant properties of 4-hydroxyl-propranolol.

  The Journal of pharmacology and experimental therapeutics 20040101

• Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

  Journal of pharmacological and toxicological methods 20040101

• Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property.

  American journal of physiology. Heart and circulatory physiology 20040101

• Alpha-tocopherol preserves endothelial cell migration in the presence of cell-oxidized low-density lipoprotein by inhibiting changes in cell membrane fluidity.

  Journal of vascular surgery 20040101

• Effects of probucol on renal function and urinary protein excretion in spontaneously hypercholesterolemic rats fed a normal or high cholesterol diet.

  Kidney & blood pressure research 20040101

• Plant sterols: factors affecting their efficacy and safety as functional food ingredients.

  Lipids in health and disease 20040101

• Role of antioxidant enzymes and antioxidant compound probucol in antiradical protection of pancreatic beta-cells during alloxan-induced diabetes.

  Bulletin of experimental biology and medicine 20040101

• Effect of Lovastatin on lipid peroxidation and total antioxidant concentrations in hemodialysis patients.

  Lipids in health and disease 20040101

• Amelioration of the beta-cell dysfunction in diabetic APA hamsters by antioxidants and AGE inhibitor treatments.

  Diabetes/metabolism research and reviews 20040101

• Management of hyperlipidaemia associated with heart transplantation.

  Drugs 20040101

• Exploring effects of different antioxidants on dexamethasone-induced lipid peroxidation using common laboratory markers.

  Acta poloniae pharmaceutica 20040101

• Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study).

  Cardiovascular diabetology 20040101

• Probucol as a potent inhibitor of oxygen radical-induced lipid peroxidation and DNA damage: in vitro studies.

  Redox report : communications in free radical research 20040101

• Probucol, a hypocholesterolemic agent, prevents the development of uterine adenomyosis induced by pituitary grafting in mice.

  Anticancer research 20040101

• Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20031201

• Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies.

  Current opinion in lipidology 20031201

• Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1.

  Atherosclerosis 20031201

• Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins.

  Atherosclerosis 20031201

• Homozygous familial hypercholesterolaemia: development of xanthogranuloma in a boy at puberty under long-term low-density lipoprotein apheresis and drug therapy.

  The British journal of dermatology 20031201

• Induction of NAD(P)H:quinone reductase by probucol: a possible mechanism for protection against chemical carcinogenesis and toxicity.

  Pharmacology & toxicology 20031201

• Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.

  Clinical and experimental pharmacology & physiology 20031201

• Dietary prevention of post-angioplasty restenosis. From illusion and disillusion to pragmatism.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20031201

• New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity.

  Cancer chemotherapy and pharmacology 20031101

• Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth.

  Expert opinion on investigational drugs 20031101

• Modulation of HDL metabolism by probucol in complete cholesteryl ester transfer protein deficiency.

  Atherosclerosis 20031101

• Probucol restores the defective leukocyte-endothelial interaction in experimental diabetes.

  European journal of pharmacology 20031008

• Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver.

  Biological & pharmaceutical bulletin 20031001

• Cytochrome P450-mediated oxidative damage of nuclear membrane proteins and its prevention by vitamin C.

  Indian journal of biochemistry & biophysics 20031001

• Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20030901

• Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.

  The American journal of pathology 20030901

• Optimizing probucol administration to preserve left ventricular compliance after reperfusion injury in the heterotopic rat heart isograft.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20030901

• Vascular protectants for the treatment of atherosclerosis.

  Expert review of cardiovascular therapy 20030901

• Novel 3-O-acyl mesquitol analogues as free-radical scavengers and enzyme inhibitors: synthesis, biological evaluation and structure-activity relationship.

  Bioorganic & medicinal chemistry letters 20030818

• Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats.

  Journal of the American Society of Nephrology : JASN 20030801

• Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.

  Bulletin of experimental biology and medicine 20030801

• Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus.

  Bulletin of experimental biology and medicine 20030801

• Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.

  Journal of medicinal chemistry 20030703

• NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.

  Journal of molecular and cellular cardiology 20030701

• Mechanisms of glomerular immune injury: effects of antioxidant treatment.

  Journal of the American Society of Nephrology : JASN 20030701

• Signal jammer. An academic experiment leads to a new class of drug for attacking heart disease.

  Scientific American 20030701

• Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.

  Molecular and cellular biochemistry 20030701

• Protective effects of probucol treatment on pancreatic beta-cell function of SZ-induced diabetic APA hamsters.

  Experimental animals 20030701

• AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

  The Journal of pharmacology and experimental therapeutics 20030601

• Oxidized low-density lipoprotein inhibits endothelium-dependent vasodilation by an antioxidant-sensitive, lysophosphatidylcholine-independent mechanism.

  Journal of cardiovascular pharmacology 20030601

• Effects of candesartan and probucol on restenosis after coronary stenting: results of insight of stent intimal hyperplasia inhibition by new angiotensin II receptor antagonist (ISHIN) trial.

  Circulation journal : official journal of the Japanese Circulation Society 20030601

• A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits.

  International immunopharmacology 20030501

• Probucol promotes functional reendothelialization in balloon-injured rabbit aortas.

  Circulation 20030422

• Antioxidants, statins, and atherosclerosis.

  Journal of the American College of Cardiology 20030402

• Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study.

  Journal of hepatology 20030401

• [Prevention of restenosis after PTCA and patient's QOL].

  Nihon rinsho. Japanese journal of clinical medicine 20030401

• [Prevention of postangioplasty restenosis].

  Nihon rinsho. Japanese journal of clinical medicine 20030401

• [Treatment of high blood cholesterol in patients with coronary heart disease].

  Nihon rinsho. Japanese journal of clinical medicine 20030401

• Tumor necrosis factor-alpha in low doses preactivates and activates macrophages by increasing their ability to produce reactive oxygen species and oxidize low-density lipoproteins: protective effect of antioxidants.

  Bulletin of experimental biology and medicine 20030401

• NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein.

  Biochemical and biophysical research communications 20030328

• Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes.

  Journal of the American College of Cardiology 20030305

• Optimal management of nonalcoholic fatty liver/steatohepatitis.

  Journal of clinical gastroenterology 20030301

• Probucol in the treatment of nonalcoholic steatohepatitis: an open-labeled study.

  Journal of clinical gastroenterology 20030301

• Differential effects of catalase on apoptosis induction in human promonocytic cells. Relationships with heat-shock protein expression.

  Molecular pharmacology 20030301

• Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease.

  Trends in molecular medicine 20030301

• Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.

  The American journal of cardiology 20030206

• Clinical results with AGI-1067: a novel antioxidant vascular protectant.

  The American journal of cardiology 20030206

• Effects of AGI-1067 and probucol after percutaneous coronary interventions.

  Circulation 20030204

• Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.

  The Journal of biological chemistry 20030131

• Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney.

  Kidney international 20030101

• Resolution of typical lipoprotein glomerulopathy by intensive lipid-lowering therapy.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030101

• Oxidized low-density lipoprotein and high-density lipoprotein cholesterol modulate coronary arterial remodeling: an intravascular ultrasound study.

  Clinical cardiology 20030101

• Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients.

  Drugs 20030101

• Ascorbic acid augments cytotoxicity induced by oxidized low-density lipoprotein.

  Journal of atherosclerosis and thrombosis 20030101

• Alpha-tocopherol modulates the low density lipoprotein receptor of human HepG2 cells.

  Nutrition journal 20030101

• The antiatherogenic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.

  Cardiovascular drug reviews 20030101

• Potential role of the interaction between equine estrogens, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in the prevention of coronary heart and neurodegenerative diseases in postmenopausal women.

  Lipids in health and disease 20030101

• Effects of probucol on endothelial damage by 5-fluorouracil.

  Acta oncologica (Stockholm, Sweden) 20030101

• The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease.

  Neuroscience 20030101

• Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-alpha expression.

  BMC pharmacology 20030101

• Equine estrogens differentially inhibit DNA fragmentation induced by glutamate in neuronal cells by modulation of regulatory proteins involved in programmed cell death.

  BMC neuroscience 20030101

• [The history of experimental diabetes in Iaşi ].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

• [The use of antioxidants and antihypoxants for decreasing of LDL oxidation by macrophages and endothelial cells in ischemia and reperfusion of vascular wall].

  Biomeditsinskaia khimiia 20030101

• Effect of antioxidant probucol for preventing stent restenosis.

  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021201

• [Effect of probucol on the blood concentration of cyclosporin A in patients with nephrotic syndrome: a case study with a microemulsion formulation (Neoral)].

  Nihon Jinzo Gakkai shi 20021201

• Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents.

  Journal of medicinal chemistry 20021121

• Application of quantitative competitive polymerase chain reaction for measurements of mRNA from antioxidative enzymes in the diabetic rat retina and kidney.

  Metabolism: clinical and experimental 20021001

• Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021001

• The effect of probucol on atherosclerosis in streptozotocin-induced diabetic-hyperlipidemic APA hamsters in different stages of atherosclerosis.

  Experimental animals 20021001

• Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification.

  Endocrinology 20020901

• Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells.

  Hypertension (Dallas, Tex. : 1979) 20020901

• Japanese familial hypercholesterolaemia with a 327insC mutation in the LDL receptor gene.

  Annals of clinical biochemistry 20020901

• Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats.

  Pharmaceutical research 20020901

• Gateways to Clinical Trials.

  Methods and findings in experimental and clinical pharmacology 20020901

• Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.

  Atherosclerosis 20020801

• Effect of probucol on cytochrome P450 activities in human liver microsomes.

  Biological & pharmaceutical bulletin 20020801

• Effects of probucol in hyperlipidemic rabbit liver: a preliminary ultrastructural study.

  Okajimas folia anatomica Japonica 20020801

• Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation.

  Circulation 20020716

• Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes.

  Diabetes research and clinical practice 20020701

• DNA damage and the effect of antioxidants in streptozotocin-treated mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701

• Potential emerging therapeutic strategies to prevent restenosis in the peripheral vasculature.

  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20020701

• Intensification of free radical oxidation of low-density lipoproteins in the plasma of patients with ischemic heart disease receiving beta-hydroxy-beta-methylglutaryl-coenzyme A reductase inhibitor cerivastatin and inhibition of low-density lipoprotein peroxidation with antioxidant probucol.

  Bulletin of experimental biology and medicine 20020701

• Antioxidative activity of green tea polyphenol in cholesterol-fed rats.

  Journal of agricultural and food chemistry 20020605

• Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells in vitro.

  Acta pharmacologica Sinica 20020601

• Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis.

  Japanese journal of pharmacology 20020601

• Policosanol: a new treatment for cardiovascular disease?

  Alternative medicine review : a journal of clinical therapeutic 20020601

• Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat.

  Circulation 20020528

• Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis.

  Circulation 20020514

• Inhibitory effect of a novel water-soluble vitamin E derivative on atherosclerosis in rabbits.

  Atherosclerosis 20020501

• Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants.

  Journal of the American Chemical Society 20020501

• Immunomodulation with DiNAC-- a new approach to the treatment of atherosclerosis?

  Expert opinion on investigational drugs 20020501

• 2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5.

  Journal of natural products 20020501

• Anti-lipid-peroxidative principles from Tournefortia sarmentosa.

  Journal of natural products 20020501

• [Anti-hyperlipidemic agents].

  Nihon rinsho. Japanese journal of clinical medicine 20020501

• Effects of antioxidants on kidney disease.

  Mechanisms of ageing and development 20020430

• The effect of antioxidants on glycated albumin-induced cytotoxicity in bovine retinal pericytes.

  Biochemical and biophysical research communications 20020412

• Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.

  Atherosclerosis 20020401

• Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits.

  Clinica chimica acta; international journal of clinical chemistry 20020301

• Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.

  British journal of pharmacology 20020301

• Effects of plaque composition on vascular remodelling after angioplasty in the MultiVitamins and Probucol (MVP) trial.

  The Canadian journal of cardiology 20020301

• [Pharmacokinetics and relative bioavailability of probucol inclusion complex capsule in healthy dogs].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020301

• Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot study.

  Wiener klinische Wochenschrift 20020227

• Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST).

  Journal of the American College of Cardiology 20020220

• Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression.

  Journal of the American College of Cardiology 20020102

• Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

  Journal of cellular biochemistry 20020101

• Drug reverses coronary atherosclerosis.

  Drug discovery today 20020101

• Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment.

  Seminars in radiation oncology 20020101

• Effects of Ginkgo biloba extract on the proliferation of vascular smooth muscle cells in vitro and on intimal thickening and interleukin-1beta expression after balloon injury in cholesterol-fed rabbits in vivo.

  Journal of cellular biochemistry 20020101

• Effects of pravastatin on exercise electrocardiography test performance and cardiovascular mortality and morbidity in patients with hypercholesterolemia: Lipid Intervention Study in Kyoto.

  Circulation journal : official journal of the Japanese Circulation Society 20020101

• Probucol and liver efficiency during chemically-induced hepatocarcinogenesis.

  Anticancer research 20020101

• Evaluation of probucol as suppressor of ceftizoxime induced lipid peroxidation.

  Acta poloniae pharmaceutica 20020101

• The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits.

  Journal of atherosclerosis and thrombosis 20020101

• Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats.

  Journal of diabetes and its complications 20020101

• [Invasive cardiology: focus on restenosis. Part II].

  Kardiologiia 20020101

• Prevention of restenosis with antioxidants: mechanisms and implications.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

• Relationship between free radicals produced by entamoeba histolytica and its proteases complex activity.

  Revista latinoamericana de microbiologia 20020101

• Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats.

  Diabetes 20011201

• Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.

  The Journal of clinical investigation 20011201

• Low-density lipoprotein-antioxidant constituents of Saururus chinensis.

  Journal of natural products 20011201

• [Lipid-lowering drugs].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201

• Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells.

  Free radical research 20011201

• Fluvastatin depresses the enhanced lipid peroxidation in vitamin E-deficient hamsters.

  Free radical research 20011201

• Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease.

  Life sciences 20011130

• A novel series of 2,6,7-substituted 2,3-dihydro-1,4-benzodioxin and 2,6,7-substituted 1,4-benzodioxin derivatives as lipid peroxidation inhibitors. Structure-activity relationships for high inhibition of human low-density lipoprotein peroxidation.

  Journal of medicinal chemistry 20011108

• Anti-atherogenic antioxidants regulate the expression and function of proteasome alpha-type subunits in human endothelial cells.

  The Journal of biological chemistry 20011102

• Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression.

  Atherosclerosis 20011101

• Allergic reactions at repeat femoral angiography with ioxaglate.

  Acta radiologica (Stockholm, Sweden : 1987) 20011101

• N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.

  The Journal of pharmacology and experimental therapeutics 20011001

• A dynamic in vitro lipolysis model. II: Evaluation of the model.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011001

• Antioxidant compounds and Ca(2+) pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity.

  Journal of neuroscience research 20011001

• [Effect of probucol on the concentration of cyclosporin A in patients with nephrotic syndrome].

  Nihon Jinzo Gakkai shi 20011001

• Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes.

  Current eye research 20011001

• Alpha-tocopherol and probucol reduce autoantibody titer to MDA-LDL in hypercholesterolemic rabbits.

  Free radical biology & medicine 20010915

• Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins.

  Journal of molecular and cellular cardiology 20010901

• Restenosis drug discovery--a formidable task.

  Current opinion in investigational drugs (London, England : 2000) 20010901

• Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.

  Life sciences 20010810

• Action of the novel antioxidants 4GBE43 and 2BBE43 against lipid peroxidation.

  Biochemical pharmacology 20010801

• Oxidants and antioxidants in atherosclerosis.

  Current opinion in lipidology 20010801

• Antioxidative properties of probucol estimated by the reactivity with superoxide and by electrochemical oxidation.

  Chemical & pharmaceutical bulletin 20010801

• Angiotensin-converting enzyme inhibitors and probucol suppress the time-dependent increase in urinary Type IV collagen excretion of Type II diabetes mellitus patients with early diabetic nephropathy.

  Clinical nephrology 20010801

• Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C.

  Microcirculation (New York, N.Y. : 1994) 20010801

• Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20010801

• Apheresis technology for prevention and regression of atherosclerosis.

  Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis 20010801

• A comparison of alternative polymer excipients and processing methods for making solid dispersions of a poorly water soluble drug.

  International journal of pharmaceutics 20010703

• Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20010701

• Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment.

  Metabolism: clinical and experimental 20010601

• Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.

  Journal of hypertension 20010601

• Characterization of simple and reproducible vascular stenosis model in hypercholesterolemic hamsters.

  Lipids 20010501

• Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents.

  Lipids 20010501

• The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.

  The Journal of biological chemistry 20010427

• Structure, function and regulation of the ABC1 gene product.

  Current opinion in lipidology 20010401

• Treatment of hyperlipidemia in HIV-infected patients.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010401

• Specific antioxidant activity of caffeoyl derivatives and other natural phenolic compounds: LDL protection against oxidation and decrease in the proinflammatory lysophosphatidylcholine production.

  Journal of natural products 20010401

• Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells.

  Atherosclerosis 20010301

• Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo.

  Arteriosclerosis, thrombosis, and vascular biology 20010301

• Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes.

  Free radical research 20010301

• Lipids and atherosclerosis: clinical management of hypercholesterolaemia.

  Expert opinion on pharmacotherapy 20010301

• [Pathogenesis of hypolipidemia].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Probucol].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Nicotinic acid and the derivative].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Antioxidants].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Treatments for dyslipidemia associated with kidney disease].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons.

  The Journal of biological chemistry 20010216

• Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat.

  European journal of pharmacology 20010209

• The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.

  Atherosclerosis 20010201

• Effects of probucol on rat carotid artery responses to balloon catheter injury.

  Atherosclerosis 20010201

• Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.

  The Journal of pharmacy and pharmacology 20010201

• Apoptosis in adriamycin cardiomyopathy and its modulation by probucol.

  Antioxidants & redox signaling 20010201

• [Hyperlipidemia and cerebrovascular disease].

  Nihon rinsho. Japanese journal of clinical medicine 20010201

• Antioxidant therapy attenuates JNK activation and apoptosis in the remote noninfarcted myocardium after large myocardial infarction.

  Biochemical and biophysical research communications 20010112

• Impact of residual plaque burden after balloon angioplasty in the MultiVitamins and Probucol (MVP) trial.

  The Canadian journal of cardiology 20010101

• A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model.

  Histology and histopathology 20010101

• [Antioxidative effects of fluvastatin, and its major metabolites [II]].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

• Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus.

  BMC medical genetics 20010101

• Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

  Arzneimittel-Forschung 20010101

• Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells.

  Journal of cellular biochemistry 20010101

• Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits.

  Oncology reports 20010101

• Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women.

  Menopause (New York, N.Y.) 20010101

• [Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol].

  Voprosy meditsinskoi khimii 20010101

• Evaluation of alpha-tocopherol, probucol and ascorbic acid as suppressors of digoxin induced lipid peroxidation.

  Acta poloniae pharmaceutica 20010101

• Oxidative stress and functional deficit in diabetic cardiomyopathy.

  Advances in experimental medicine and biology 20010101

• Type 2 diabetes: pharmacological intervention in an animal model.

  Advances in experimental medicine and biology 20010101

• [A 50-year history of new drugs in Japan: the developments and trends of antihyperlipidemic drugs].

  Yakushigaku zasshi 20010101

• Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells.

  Cytotechnology 20010101

• Effects of probucol on cholesterol metabolism in mouse peritoneal macrophages: inhibition of HDL-mediated cholesterol efflux.

  Atherosclerosis 20001001

• Nephrin in experimental glomerular disease.

  Kidney international 20001001

• Effect of probucol on repeat revascularization rate after percutaneous transluminal coronary angioplasty (from the Probucol Angioplasty Restenosis Trial [PART]).

  The American journal of cardiology 20000901

• Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats.

  Cardiovascular research 20000601

• Adriamycin-induced heart failure: mechanism and modulation.

  Molecular and cellular biochemistry 20000401

• Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.

  Kidney international 19991201

• Attenuation of reperfusion injury with probucol in the heterotopic rat cardiac isograft.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 19990801

• Combined effects of probucol and benzafibrate on lipoprotein metabolism and liver cholesteryl ester transfer protein mRNA in cholesterol-fed rabbits.

  Japanese circulation journal 19990601

• Zinc accumulation in adriamycin-induced cardiomyopathy in rats: effects of melatonin, a cardioprotective antioxidant.

  Journal of pineal research 19990501

• Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice.

  Atherosclerosis 19981201

• Some natural and synthetic antioxidants as stabilizers of beta-carotene conversion into vitamin A.

  Biochemistry. Biokhimiia 19980201

• Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.

  Journal of the American Society of Nephrology : JASN 19980201

• Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats.

  Life sciences 19980101

• Effectiveness of an antioxidant in preventing restenosis after percutaneous transluminal coronary angioplasty: the Probucol Angioplasty Restenosis Trial.

  Journal of the American College of Cardiology 19971001

• Inhibition of progression of chronic puromycin aminonucleoside nephrosis by probucol, an antioxidant.

  Journal of the American Society of Nephrology : JASN 19961101

• The mitogenic effect of H2O2 for vascular smooth muscle cells is mediated by an increase of the affinity of basic fibroblast growth factor for its receptor.

  FEBS letters 19961014

• Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender.

  American heart journal 19960601

• The protective effect of probucol on adriamycin nephrosis in the rat.

  Nihon Jinzo Gakkai shi 19951101

• Currently available hypolipidaemic drugs and future therapeutic developments.

  Bailliere's clinical endocrinology and metabolism 19951001

• Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.

  Circulation 19950715

• [The ameliorative effect of probucol on adriamycin (ADR) induced nephrotic rats].

  Nihon Jinzo Gakkai shi 19950301

• 3,5-Di-t-butyl-4-hydroxytoluene (BHT) and probucol stimulate selectively the reaction of mammalian 15-lipoxygenase with biomembranes.

  Biochimica et biophysica acta 19950103

• Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect.

  Circulation 19950101

• Antihyperlipidaemic agents. Drug interactions of clinical significance.

  Drug safety 19941101

• Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats.

  Circulation 19940601

• Probucol-induced QT prolongation and syncope.

  Japanese circulation journal 19940501

• Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia.

  Lancet (London, England) 19930109

• Polymorphic ventricular tachycardia (Torsade de Pointes) associated with the use of probucol.

  The New England journal of medicine 19920521

• Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.

  Journal of medicinal chemistry 19911001

• Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19900401

• Lipid-lowering agents in proteinuric diseases.

  American journal of nephrology 19900101

• Structural changes in oxidised low-density lipoproteins and of the effect of the anti-atherosclerotic drug probucol observed by synchrotron X-ray and neutron solution scattering.

  European journal of biochemistry 19890801

• Treatment of heterozygous familial hypercholesterolemia with lipid-lowering drugs.

  Arteriosclerosis (Dallas, Tex.) 19890101

• Probucol-induced QT prolongation and torsades de pointes.

  Japanese journal of medicine 19890101

• Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate.

  Journal of pharmacobio-dynamics 19870301

• Effect of probucol on plasma lipids and lipoproteins in type IIb hyperlipoproteinemia.

  Atherosclerosis 19801101

• Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors.

  Pacing and clinical electrophysiology : PACE 19790701

• Sensitization to epinephrine-induced ventricular fibrillation produced by probucol in dogs.

  Toxicology and applied pharmacology 19730401